ES2012532A6 - Un procedimiento para la preparacion de una solucion acuosa de b-metil-4-(2' -tienilcarbonil)fenilacetato de lisina para aplicacion topica oftalmica. - Google Patents

Un procedimiento para la preparacion de una solucion acuosa de b-metil-4-(2' -tienilcarbonil)fenilacetato de lisina para aplicacion topica oftalmica.

Info

Publication number
ES2012532A6
ES2012532A6 ES8802245A ES8802245A ES2012532A6 ES 2012532 A6 ES2012532 A6 ES 2012532A6 ES 8802245 A ES8802245 A ES 8802245A ES 8802245 A ES8802245 A ES 8802245A ES 2012532 A6 ES2012532 A6 ES 2012532A6
Authority
ES
Spain
Prior art keywords
alpha
methyl
phenyl acetate
thionylcarbonyl
aqueous solutions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES8802245A
Other languages
English (en)
Inventor
Lopez Amadeo Perez
Colomer Jordi Coll
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Cusi SA
Original Assignee
Laboratorios Cusi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Cusi SA filed Critical Laboratorios Cusi SA
Priority to ES8802245A priority Critical patent/ES2012532A6/es
Priority to DE3827472A priority patent/DE3827472A1/de
Priority to SE8902529A priority patent/SE8902529L/
Priority to FR8909555A priority patent/FR2634124A1/fr
Priority to PT91182A priority patent/PT91182A/pt
Priority to BE8900772A priority patent/BE1004381A3/nl
Priority to JP1183542A priority patent/JPH0273014A/ja
Priority to IT8967594A priority patent/IT1232868B/it
Priority to GB8916337A priority patent/GB2220570B/en
Publication of ES2012532A6 publication Critical patent/ES2012532A6/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE UNA SOLUCION ACUOSA DE METIL-4-(2K-TIENILCARBONIL)FENILACETATO DE LISINA PARA APLICACION TOPICA OFTALMICA. COMPRENDE: (A) DISOLVER EN AGUA PURIFICADA EN FRIO EL METIL-4-(2K-TIENILCARBONIL-FENILACETATO DE LISINA, ISOTONIZAR EN CASO NECESARIO, AJUSTAR EL PH ENTRE 6 Y 8, AJUSTAR EL VOLUMEN, ESTERILIZAR POR FILTRACION Y, OPCIONALMENTE, AÑADIR UN TAMPON; (B) DISOLVER EN AGUA PURIFICADA UNO O VARIOS CONSERVADORES EN FRIO O EN CALIENTE DEPENDIENDO DE LOS MISMOS, ENFRIAR SI ES NECESARIO A LA TEMPERATURA AMBIENTE, AJUSTAR EL VOLUMEN CON AGUA PURIFICADA, ESTERILIZAR POR FILTRACION Y, OPCIONALMENTE, INCORPORAR UN POLIMERO HIDROFILO Y/O UN AGENTE ISOTONIZANTE; (C) MEZCLAR (A Y B) Y ENVASAR EN CONDICIONES ESTERILES; O (D) EN CONDICIONES ESTERILES, ENVASAR (B) Y LIOFILIZAR (A) PARA EFECTUAR LA SOLUCION DE FORMA EXTEMPORANEA. LAS SOLUCIONES ASI OBTENIDAS SON UTILES PARA EL TRATAMIENTO TOPICO DE LAS INFLAMACIONES OCULARES.
ES8802245A 1988-07-15 1988-07-15 Un procedimiento para la preparacion de una solucion acuosa de b-metil-4-(2' -tienilcarbonil)fenilacetato de lisina para aplicacion topica oftalmica. Expired - Fee Related ES2012532A6 (es)

Priority Applications (9)

Application Number Priority Date Filing Date Title
ES8802245A ES2012532A6 (es) 1988-07-15 1988-07-15 Un procedimiento para la preparacion de una solucion acuosa de b-metil-4-(2' -tienilcarbonil)fenilacetato de lisina para aplicacion topica oftalmica.
DE3827472A DE3827472A1 (de) 1988-07-15 1988-08-12 Verfahren zum herstellen einer waessrigen loesung von lysin-(alpha)-methyl-4-(2'-thienylcarbonyl)phenylacetat fuer die oertliche anwendung in der augenheilkunde
SE8902529A SE8902529L (sv) 1988-07-15 1989-07-13 Saett att framstaella en vattenloesning av lysin-a-metyl-4-(2'-tienylkarbonyl) fenylacetat
FR8909555A FR2634124A1 (fr) 1988-07-15 1989-07-13 Procede de preparation d'une solution aqueuse d'(alpha)-methyl-4-(2(prime)thienylcarbonyl)-phenylacetate de lysine pour une utilisation locale dans le traitement des yeux
PT91182A PT91182A (pt) 1988-07-15 1989-07-14 Processo para a preparacao de uma solucao aquosa de alfa-metil-4-(2' -tienilcarbonil)-fenilacetato de lisina
BE8900772A BE1004381A3 (nl) 1988-07-15 1989-07-14 Werkwijze voor het vervaardigen van een waterige oplossing van lysine-alpha-methyl-4-(2'-thienylcarbonyl) fenylacetaat voor lokale toepassing in ooggeneeskunde.
JP1183542A JPH0273014A (ja) 1988-07-15 1989-07-15 眼科用α―メチル―４―（２’―チエニルカルボニル）フェニル酢酸リジン液剤の製法
IT8967594A IT1232868B (it) 1988-07-15 1989-07-17 Procedimento per la produzione di una miscela acquosa di lisin metil 4- (2'- tienilcarbonil) fenilacetato per impiego locale nella medicina oftalmica
GB8916337A GB2220570B (en) 1988-07-15 1989-07-17 A method for manufacturing an aqueous solution of lysine-alpha-methyl-4-(2'-thionyl carbonyl)phenyl acetate for local application in ophthalmology

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES8802245A ES2012532A6 (es) 1988-07-15 1988-07-15 Un procedimiento para la preparacion de una solucion acuosa de b-metil-4-(2' -tienilcarbonil)fenilacetato de lisina para aplicacion topica oftalmica.

Publications (1)

Publication Number Publication Date
ES2012532A6 true ES2012532A6 (es) 1990-04-01

Family

ID=8257348

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8802245A Expired - Fee Related ES2012532A6 (es) 1988-07-15 1988-07-15 Un procedimiento para la preparacion de una solucion acuosa de b-metil-4-(2' -tienilcarbonil)fenilacetato de lisina para aplicacion topica oftalmica.

Country Status (9)

Country Link
JP (1) JPH0273014A (es)
BE (1) BE1004381A3 (es)
DE (1) DE3827472A1 (es)
ES (1) ES2012532A6 (es)
FR (1) FR2634124A1 (es)
GB (1) GB2220570B (es)
IT (1) IT1232868B (es)
PT (1) PT91182A (es)
SE (1) SE8902529L (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2240051B (en) * 1990-01-18 1993-04-14 Pall Corp Cylindrical filters and their manufacture
DE10106852A1 (de) * 2001-02-14 2002-09-05 T Luger Entzündungshemmende Verbindungen

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5726614A (en) * 1980-07-22 1982-02-12 Kaken Pharmaceut Co Ltd Eye drop for adjusting intraocular pressure
GB2072015B (en) * 1980-03-21 1983-12-21 Wellcome Found Compositions containing polymyxin
US4559343A (en) * 1982-09-07 1985-12-17 Alcon Laboratories, Inc. Nonirritating aqueous ophthalmic compositions comfort formulation for ocular therapeutic agents
US4657925A (en) * 1984-08-13 1987-04-14 Nelson Research & Development Co. Method and compositions for reducing the intraocular pressure of mammals
JPS60149521A (ja) * 1984-01-18 1985-08-07 Eisai Co Ltd 高眼圧・緑内障治療・予防用点眼剤
GB8426922D0 (en) * 1984-10-24 1984-11-28 Sandoz Ltd Galenic formulation
GB2167300B (en) * 1984-11-23 1988-11-23 Fisons Plc Formulations
US4728509A (en) * 1985-08-19 1988-03-01 Takeda Chemical Industries, Ltd. Aqueous liquid preparation
JPS62277323A (ja) * 1986-02-19 1987-12-02 Sankyo Co Ltd フマル酸ケトチフエン含有点眼液の製法
FR2598081B1 (fr) * 1986-04-30 1990-02-02 Chauvin Blache Lab Procede de preparation d'une solution pharmaceutique aqueuse d'un principe actif constitue par un acide organique
US5414011A (en) * 1987-09-11 1995-05-09 Syntex (U.S.A.) Inc. Preservative system for ophthalmic formulations

Also Published As

Publication number Publication date
IT8967594A0 (it) 1989-07-17
GB2220570B (en) 1992-09-30
JPH0273014A (ja) 1990-03-13
GB8916337D0 (en) 1989-08-31
FR2634124A1 (fr) 1990-01-19
PT91182A (pt) 1990-02-08
IT1232868B (it) 1992-03-05
BE1004381A3 (nl) 1992-11-10
DE3827472A1 (de) 1990-01-18
SE8902529D0 (sv) 1989-07-13
SE8902529L (sv) 1990-01-16
GB2220570A (en) 1990-01-17

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20040503