ES2011653A6 - Metodo y aparato para amezclar rapidamente pequenos volumenes con el fin de mejorar reacciones biologicas. - Google Patents

Metodo y aparato para amezclar rapidamente pequenos volumenes con el fin de mejorar reacciones biologicas.

Info

Publication number
ES2011653A6
ES2011653A6 ES8800747A ES8800747A ES2011653A6 ES 2011653 A6 ES2011653 A6 ES 2011653A6 ES 8800747 A ES8800747 A ES 8800747A ES 8800747 A ES8800747 A ES 8800747A ES 2011653 A6 ES2011653 A6 ES 2011653A6
Authority
ES
Spain
Prior art keywords
microspheres
cells
small volumes
rapid mixing
biological reactions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES8800747A
Other languages
English (en)
Inventor
Wallaceh Coulter
John David Hollinger
Thomas Russell
Carlos Rodriguez
Ronald Paul
Kenneth Kortright
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Coulter Electronics Inc
Original Assignee
Coulter Electronics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coulter Electronics Inc filed Critical Coulter Electronics Inc
Publication of ES2011653A6 publication Critical patent/ES2011653A6/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
    • B01F31/201—Holders therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
    • B01F31/22—Mixing the contents of independent containers, e.g. test tubes with supporting means moving in a horizontal plane, e.g. describing an orbital path for moving the containers about an axis which intersects the receptacle axis at an angle
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

METODO Y APARATO PARA MEZCLAR RAPIDAMENTE PEQUEÑOS VOLUMENES CON EL FIN DE MEJORAR REACCIONES BIOLOGICAS. METODO Y APARATO PARA MEZCLAR RAPIDAMENTE PEQUEÑOS VOLUMENES CON EL FIN DE MEJORAR REACCIONES BIOLOGICAS. SE DESCRIBE UN METODO Y APARATO (10), PARA ACELERAR POR LO MENOS UNA REACCION BIOLOGICA DEFINITIVA Y PARA AUMENTAR LA PRECISION DE LAS DETERMINACIONES HECHAS A PARTIR DE LA MISMA. LA REACCION IMPLICA CELULAS BIOLOGICAS VIABLES ESCOGIDAS QUE SE PREPARAN EN UN PEQUEÑO VOLUMEN DE MUESTRA (12) Y SE MEZCLAN (16) RAPIDAMENTE CON MICROESFERAS (14) QUE TIENEN UNIDO A ELLAS UN ANTICUERPO ESPECIFICO POR LO MENOS PARA CELULAS ESPECIFICAS. LAS MICROESFERAS PUEDEN SER MAGNETICAS Y LAS CELULAS UNIDAS A ELLAS PUEDEN SER RETIRADAS MAGNETICAMENTE PARA ANALIZAR LAS RESTANTES POBLACIONES DE CELULAS DE LA SANGRE. LAS MICROESFERAS PUEDEN SER INTRODUCIDAS SECUENCIAL O SIMULTANEAMENTE.
ES8800747A 1987-03-13 1988-03-11 Metodo y aparato para amezclar rapidamente pequenos volumenes con el fin de mejorar reacciones biologicas. Expired - Lifetime ES2011653A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2533787A 1987-03-13 1987-03-13

Publications (1)

Publication Number Publication Date
ES2011653A6 true ES2011653A6 (es) 1990-02-01

Family

ID=21825432

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8800747A Expired - Lifetime ES2011653A6 (es) 1987-03-13 1988-03-11 Metodo y aparato para amezclar rapidamente pequenos volumenes con el fin de mejorar reacciones biologicas.

Country Status (10)

Country Link
EP (1) EP0349591B1 (es)
KR (1) KR890700397A (es)
CN (1) CN1018673B (es)
AT (1) ATE108279T1 (es)
AU (1) AU610581B2 (es)
CA (1) CA1326435C (es)
DE (1) DE3850573T2 (es)
ES (1) ES2011653A6 (es)
NO (1) NO177809C (es)
WO (1) WO1988006918A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2644894B1 (fr) * 1989-03-24 1994-05-13 Sanofi Trousse et methode de dosage enzymatique applicables a des cellules entieres
FR2644893B1 (fr) * 1989-03-24 1991-07-12 Sanofi Sa Trousse et methode de dosage applicables a des cellules entieres
US5348859A (en) * 1990-11-23 1994-09-20 Coulter Corporation Method and apparatus for obtaining an absolute white blood cell subset count and white blood cell multipart differential
US5340719A (en) * 1990-11-23 1994-08-23 Corporation Coulter Method and apparatus for optically screening microscopic cells
HUT67053A (en) * 1990-11-23 1995-01-30 Coulter Corp Method and apparatus for optically screening microscopic cells
CN101149371B (zh) * 2007-10-26 2011-03-09 南方医科大学珠江医院 一种鼠免疫状态监测试剂及其制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3985649A (en) * 1974-11-25 1976-10-12 Eddelman Roy T Ferromagnetic separation process and material
US3970518A (en) * 1975-07-01 1976-07-20 General Electric Company Magnetic separation of biological particles
US4267234A (en) * 1978-03-17 1981-05-12 California Institute Of Technology Polyglutaraldehyde synthesis and protein bonding substrates
US4230685A (en) * 1979-02-28 1980-10-28 Northwestern University Method of magnetic separation of cells and the like, and microspheres for use therein
US4325910A (en) * 1979-07-11 1982-04-20 Technicraft, Inc. Automated multiple-purpose chemical-analysis apparatus
US4276260A (en) * 1980-01-28 1981-06-30 Coulter Electronics, Inc. Fluid transfer mechanism
DE3173747D1 (en) * 1980-11-04 1986-03-20 Olympus Optical Co Analyzing method and apparatus for immunological agglutinating reaction
WO1982003462A1 (en) * 1981-03-27 1982-10-14 Ltd Biospecia Immunological analysis and a biochemical agent therefore
US4511662A (en) * 1982-06-18 1985-04-16 Bio-Rad Laboratories, Inc. Simultaneous assay for T and B lymphocyte populations and subpopulations
US4550017A (en) * 1982-10-15 1985-10-29 Syntex (U.S.A.) Inc. Fluorescence screening for blood typing
US4485175A (en) * 1983-01-03 1984-11-27 Coulter Electronics, Inc. Method for three-volume differential determination of lymphocyte, monocyte and granulocyte populations of leukocytes
US4584277A (en) * 1983-04-05 1986-04-22 Syntex (U.S.A.) Inc. Fluorescent multiparameter particle analysis
US4672040A (en) * 1983-05-12 1987-06-09 Advanced Magnetics, Inc. Magnetic particles for use in separations
US4628026A (en) * 1983-11-15 1986-12-09 Dietlind Gardell Method and apparatus for automated double fluorochromization analysis in lymphocytotoxicity testing
JPS61225656A (ja) * 1985-03-29 1986-10-07 Toshiba Corp 検体検査装置

Also Published As

Publication number Publication date
CN1018673B (zh) 1992-10-14
DE3850573D1 (de) 1994-08-11
ATE108279T1 (de) 1994-07-15
CN88101256A (zh) 1988-09-21
AU610581B2 (en) 1991-05-23
EP0349591B1 (en) 1994-07-06
NO885042L (no) 1989-01-09
AU1570088A (en) 1988-10-10
NO885042D0 (no) 1988-11-11
EP0349591A4 (en) 1991-01-16
NO177809C (no) 1995-11-22
NO177809B (no) 1995-08-14
KR890700397A (ko) 1989-04-24
DE3850573T2 (de) 1994-10-27
CA1326435C (en) 1994-01-25
EP0349591A1 (en) 1990-01-10
WO1988006918A1 (en) 1988-09-22

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