ES2001411A6 - Un procedimiento para la preparacion de p-acilaminobenzamidas. - Google Patents

Un procedimiento para la preparacion de p-acilaminobenzamidas.

Info

Publication number
ES2001411A6
ES2001411A6 ES8601517A ES8601517A ES2001411A6 ES 2001411 A6 ES2001411 A6 ES 2001411A6 ES 8601517 A ES8601517 A ES 8601517A ES 8601517 A ES8601517 A ES 8601517A ES 2001411 A6 ES2001411 A6 ES 2001411A6
Authority
ES
Spain
Prior art keywords
acylaminobenzamides
acylamino
pharmaceutical formulations
provides certain
benzamide derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8601517A
Other languages
English (en)
Inventor
David Wayne Robertson
Beedle Edward Earl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES2001411A6 publication Critical patent/ES2001411A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE P-ACILAMINOBENZAMIDAS DE FORMULA (I) DONDE R1 ES UN RADICAL ALQUILOL, CICLOALQUILO O AMINO SUSTITUIDO, CUYOS SUSTITUYENTES CON EL N AL QUE ESTAN ENLAZADOS, PUEDEN FORMAR UN CICLO DE 5 O 6 MIEMBROS; R2-R7 SON H O -CH3 Y N ES 0 O 1, QUE COMPRENDE LA ACILACION DEL CORRESPONDIENTE DERIVADO AMINO LIBRE, CON UN AGENTE ACILANTE O LA COPULACION DEL CORRESPONDIENTE DERIVADO HALOACILADO CON UNA AMINA. LAS P-ACILAMINOBENZAMIDAS ASI OBTENIDAS, SON UTILES PARA EL TRATAMIENTO Y PREVENCION DE CONVULSIONES EN MAMIFEROS.
ES8601517A 1985-08-30 1986-08-29 Un procedimiento para la preparacion de p-acilaminobenzamidas. Expired ES2001411A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/771,455 US4642379A (en) 1985-08-30 1985-08-30 Intermediates for anticonvulsant agents

Publications (1)

Publication Number Publication Date
ES2001411A6 true ES2001411A6 (es) 1988-05-16

Family

ID=25091883

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8601517A Expired ES2001411A6 (es) 1985-08-30 1986-08-29 Un procedimiento para la preparacion de p-acilaminobenzamidas.

Country Status (17)

Country Link
US (1) US4642379A (es)
EP (1) EP0213924B1 (es)
JP (1) JPS6259249A (es)
KR (1) KR900000275B1 (es)
CN (1) CN1010680B (es)
AT (1) ATE57526T1 (es)
AU (1) AU580890B2 (es)
DE (1) DE3674971D1 (es)
DK (1) DK412286A (es)
ES (1) ES2001411A6 (es)
HU (1) HU197029B (es)
IL (1) IL79835A0 (es)
NZ (1) NZ217356A (es)
PH (1) PH23173A (es)
PT (1) PT83253B (es)
SU (1) SU1486055A3 (es)
ZA (1) ZA866429B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ219974A (en) * 1986-04-22 1989-08-29 Goedecke Ag N-(2'-aminophenyl)-benzamide derivatives, process for their preparation and their use in the control of neoplastic diseases
US4981866A (en) * 1987-02-18 1991-01-01 Eli Lilly And Company Anticonvulsant agents
US4939163A (en) * 1987-02-18 1990-07-03 Eli Lilly And Company Anticonvulsant agents
US4835181A (en) * 1987-02-18 1989-05-30 Eli Lilly And Company Anticonvulsant agents using cyano dimethylphenyl benzamides
AU710071B2 (en) * 1996-05-14 1999-09-16 Bristol-Myers Squibb Company Anticonvulsant pyridinyl benzamide derivatives
JP2010535172A (ja) * 2007-08-02 2010-11-18 エフ．ホフマン−ラ ロシュ アーゲー Ｃｎｓ障害の処置のためのベンズアミド誘導体の使用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2224153B1 (es) * 1973-04-04 1977-11-10 Upjohn Co
US4004029A (en) * 1974-05-13 1977-01-18 The Upjohn Company Compositions and method for treating epilepsy and convulsions
JPS56156246A (en) * 1980-05-06 1981-12-02 Hodogaya Chem Co Ltd Benzamide derivative and herbicide comprising it
JPS5780351A (en) * 1980-11-06 1982-05-19 Hodogaya Chem Co Ltd Benzamide derivative and herbicide containing the same
US4379165A (en) * 1981-05-18 1983-04-05 Research Corporation Anti-convulsant
US4629740A (en) * 1984-04-10 1986-12-16 Eli Lilly And Company Anticonvulsant agents
US4835181A (en) * 1987-02-18 1989-05-30 Eli Lilly And Company Anticonvulsant agents using cyano dimethylphenyl benzamides

Also Published As

Publication number Publication date
HU197029B (en) 1989-02-28
NZ217356A (en) 1989-05-29
AU580890B2 (en) 1989-02-02
EP0213924B1 (en) 1990-10-17
IL79835A0 (en) 1986-11-30
CN1010680B (zh) 1990-12-05
PH23173A (en) 1989-05-19
KR870002053A (ko) 1987-03-28
PT83253A (en) 1986-09-01
US4642379A (en) 1987-02-10
EP0213924A3 (en) 1987-09-30
DE3674971D1 (en) 1990-11-22
JPS6259249A (ja) 1987-03-14
DK412286D0 (da) 1986-08-29
KR900000275B1 (ko) 1990-01-24
PT83253B (pt) 1989-03-30
ZA866429B (en) 1988-04-27
HUT41817A (en) 1987-05-28
DK412286A (da) 1987-03-01
SU1486055A3 (ru) 1989-06-07
AU6206486A (en) 1987-03-05
EP0213924A2 (en) 1987-03-11
CN86105906A (zh) 1987-02-25
ATE57526T1 (de) 1990-11-15

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