ES2001290A6 - Procedimiento para aislar (+)-6-cloro-5,10-dihidro-5-(1-metil-4-piperidil)-acetil)-11h-dibenzo(b,e)-(1,4)-diazepin-11-ona" - Google Patents

Procedimiento para aislar (+)-6-cloro-5,10-dihidro-5-(1-metil-4-piperidil)-acetil)-11h-dibenzo(b,e)-(1,4)-diazepin-11-ona"

Info

Publication number
ES2001290A6
ES2001290A6 ES8601622A ES8601622A ES2001290A6 ES 2001290 A6 ES2001290 A6 ES 2001290A6 ES 8601622 A ES8601622 A ES 8601622A ES 8601622 A ES8601622 A ES 8601622A ES 2001290 A6 ES2001290 A6 ES 2001290A6
Authority
ES
Spain
Prior art keywords
diazepin
dibenzo
piperidinyl
dihydro
acetyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8601622A
Other languages
English (en)
Inventor
Gunter Trummlitz
Wolfhard Engel
Wolfgang Eberlein
Gerhard Mihm
Antonio Giachetti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES2001290A6 publication Critical patent/ES2001290A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE AISLA (+)-6-CLORO-5,10-DIHIDRO-5''-(1-METIL-4-PIPERIDINIL)-ACETIL)-11H-DIBENZO(B,E)-(1,4)-DIAZEPIN-11-ONA, Y EVENTUALMENTE SE PREPARA SUS SALES CON ACIDOS INORGANICOS U ORGANICOS, TRANSFORMANDO LA FORMA RACEMICA DEL COMPUESTO DE FORMULA CON UN ACIDO OPTICAMENTE ACTIVO, EN UN DISOLVENTE, EN SALES DIASTEREOISOMERAS, SEPARANDO ESTAS SEGUN SUS DIFERENTES SOLUBILIDADES, Y AISLANDO A PARTIR DE LA SAL DE FORMA (+), ASI OBTENIDA, MEDIANTE LA ADICION DE ALCALI, LA BASE LIBRE, Y TRANSFORMANDO EVENTUALMENTE DESPUES LA BASE LIBRE MEDIANTE ACIDOS INORGANICOS U ORGANICOS EN SUS SALES CORRESPONDIENTES. EL PRODUCTO AISLADO ES UTIL PARA PREPARAR MEDICAMENTOS ANTIULCEROGENOS E INHIBIDORES DE LA SECRECION DE LOS ACIDOS GASTRICOS.
ES8601622A 1985-09-05 1986-09-04 Procedimiento para aislar (+)-6-cloro-5,10-dihidro-5-(1-metil-4-piperidil)-acetil)-11h-dibenzo(b,e)-(1,4)-diazepin-11-ona" Expired ES2001290A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853531682 DE3531682A1 (de) 1985-09-05 1985-09-05 (+)-6-chlor-5,10-dihydro-5-((1-methyl-4- piperidinyl)acetyl)-11h-dibenzo(b,e)(1,4) diazepin-11-on, seine isolierung und verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
ES2001290A6 true ES2001290A6 (es) 1988-05-01

Family

ID=6280185

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8601622A Expired ES2001290A6 (es) 1985-09-05 1986-09-04 Procedimiento para aislar (+)-6-cloro-5,10-dihidro-5-(1-metil-4-piperidil)-acetil)-11h-dibenzo(b,e)-(1,4)-diazepin-11-ona"

Country Status (17)

Country Link
US (1) US4668674A (es)
EP (1) EP0214528A3 (es)
JP (1) JPS6256478A (es)
KR (1) KR870003097A (es)
AU (1) AU582271B2 (es)
DD (1) DD251976A5 (es)
DE (1) DE3531682A1 (es)
DK (1) DK423886A (es)
ES (1) ES2001290A6 (es)
FI (1) FI863549A (es)
GR (1) GR862242B (es)
HU (1) HU195499B (es)
IL (1) IL79933A0 (es)
NO (1) NO863539L (es)
NZ (1) NZ217462A (es)
PT (1) PT83308B (es)
ZA (1) ZA866703B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2206880B (en) * 1987-07-16 1991-04-24 Farmos Oy Optical isomers of an imidazole derivative
DE3738980A1 (de) * 1987-11-17 1989-05-24 Thomae Gmbh Dr K Mittel zur behandlung von ischaemischen herzerkrankungen
DE3855159D1 (de) * 1987-12-22 1996-05-02 Byk Gulden Lomberg Chem Fab Thienotricyclen zur Behandlung von Erkrankungen der Bronchien
DE4138909A1 (de) * 1991-11-27 1993-06-03 Bayer Ag Aminoalkyl-substituierte 5,6-dihydro-dibenz(b,e)azepin-6,11-dion-11-oxime
US5439109A (en) * 1993-12-28 1995-08-08 Bag-It Products Corp. Line storage device
US6333322B1 (en) * 1996-03-13 2001-12-25 Eisai Co., Ltd. Nitrogen-containing tricyclic compounds and drugs containing the same
WO2024059085A1 (en) * 2022-09-12 2024-03-21 Invea Therapeutics, Inc. Compositions and methods for treatment of inflammatory diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3028001A1 (de) * 1980-07-24 1982-02-18 Dr. Karl Thomae Gmbh, 7950 Biberach Neue, in 5-stellung substituierte 5,10-dihydro-11h-dibenzo (b,e)(1,4) diazepin-11-one, verfahren zu ihrer herstellung und diese verbindung enthaltende arzneimittel
DE3204157A1 (de) * 1982-02-06 1983-08-11 Dr. Karl Thomae Gmbh, 7950 Biberach Substituierte dibenzodiazepinone, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
DE3402060A1 (de) * 1984-01-21 1985-08-01 Dr. Karl Thomae Gmbh, 7950 Biberach Substituierte 5,11-dihydro-6h-dibenz(b,e)azepin-6-one, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3409237A1 (de) * 1984-03-14 1985-09-19 Dr. Karl Thomae Gmbh, 7950 Biberach Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
IL79933A0 (en) 1986-12-31
AU582271B2 (en) 1989-03-16
NO863539D0 (no) 1986-09-04
NO863539L (no) 1987-03-06
KR870003097A (ko) 1987-04-15
DD251976A5 (de) 1987-12-02
EP0214528A3 (de) 1987-08-05
HUT42472A (en) 1987-07-28
JPS6256478A (ja) 1987-03-12
PT83308A (de) 1986-10-01
HU195499B (en) 1988-05-30
DK423886A (da) 1987-03-06
DK423886D0 (da) 1986-09-04
US4668674A (en) 1987-05-26
FI863549A0 (fi) 1986-09-03
DE3531682A1 (de) 1987-03-12
NZ217462A (en) 1988-11-29
AU6234186A (en) 1987-03-12
EP0214528A2 (de) 1987-03-18
ZA866703B (en) 1988-05-25
PT83308B (de) 1988-10-07
GR862242B (en) 1987-01-02
FI863549A (fi) 1987-03-06

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001204