ES2001266A6 - Process for the production of the 2-ketoglutarate salt of vincamine - Google Patents

Process for the production of the 2-ketoglutarate salt of vincamine

Info

Publication number
ES2001266A6
ES2001266A6 ES8601367A ES8601367A ES2001266A6 ES 2001266 A6 ES2001266 A6 ES 2001266A6 ES 8601367 A ES8601367 A ES 8601367A ES 8601367 A ES8601367 A ES 8601367A ES 2001266 A6 ES2001266 A6 ES 2001266A6
Authority
ES
Spain
Prior art keywords
vincamine
salt
production
base
ketoglutarate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8601367A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arysearch Arylan AG
Original Assignee
Arysearch Arylan AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arysearch Arylan AG filed Critical Arysearch Arylan AG
Publication of ES2001266A6 publication Critical patent/ES2001266A6/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Process for the production of the 2-ketoglutarate salt of vincamine in the aqueous phase. According to the invention, an aqueous suspension of vincamine base, heated to 15-50 DEG C and stirred, is prepared separately, to which there is added, rapidly and while continually stirring, an aqueous solution of 2-ketoglutaric acid, also heated to a temperature of between 15 and 50 DEG C, this addition causing first the vincamine base to dissolve and then immediate reaction between the vincamine base and the above acid, the 2-ketoglutarate salt of the vincamine dissolved in water being obtained, the above salt is left to crystallise in a few minutes in the form of a compact mass and, after cooling to a temperature between +4 and +10 DEG C to complete this crystallisation, this mass is separated completely from the aqueous medium.
ES8601367A 1985-08-27 1986-08-26 Process for the production of the 2-ketoglutarate salt of vincamine Expired ES2001266A6 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH3666/85A CH663789A5 (en) 1985-08-27 1985-08-27 PROCEDURE FOR THE PRODUCTION OF VINCAMINA 2-KETOGLUTARATE SALT.

Publications (1)

Publication Number Publication Date
ES2001266A6 true ES2001266A6 (en) 1988-05-01

Family

ID=4260894

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8601367A Expired ES2001266A6 (en) 1985-08-27 1986-08-26 Process for the production of the 2-ketoglutarate salt of vincamine

Country Status (4)

Country Link
CH (1) CH663789A5 (en)
ES (1) ES2001266A6 (en)
FR (1) FR2586682B1 (en)
IT (1) IT1197858B (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES430063A1 (en) * 1974-09-14 1976-10-01 Corbera Gubern Ketoglutaric acid derivatives
US4362730A (en) * 1980-08-25 1982-12-07 Heinrich Mack Nachf. Chem-Pharm. Fabrik Vincamine saccharinate and a pharmaceutical composition containing it dissolved therein
DE3113132A1 (en) * 1981-04-01 1982-10-21 Heinrich Mack Nachf., 7918 Illertissen VINCAMINE CYCLAMATE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THIS

Also Published As

Publication number Publication date
IT8621449A1 (en) 1988-02-08
FR2586682A1 (en) 1987-03-06
IT8621449A0 (en) 1986-08-08
IT1197858B (en) 1988-12-21
FR2586682B1 (en) 1990-02-02
CH663789A5 (en) 1988-01-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001102