EP4491709A4 - O-acetyl-homoserin-produzierender mikroorganismus und verfahren zur herstellung von o-acetyl-homoserin oder l-methionin damit - Google Patents
O-acetyl-homoserin-produzierender mikroorganismus und verfahren zur herstellung von o-acetyl-homoserin oder l-methionin damitInfo
- Publication number
- EP4491709A4 EP4491709A4 EP23781125.2A EP23781125A EP4491709A4 EP 4491709 A4 EP4491709 A4 EP 4491709A4 EP 23781125 A EP23781125 A EP 23781125A EP 4491709 A4 EP4491709 A4 EP 4491709A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- homoserin
- acetyl
- producing
- methionine
- microorganism
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/12—Methionine; Cysteine; Cystine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
- C12Y305/01098—Histone deacetylase (3.5.1.98), i.e. sirtuin deacetylase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/15—Corynebacterium
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020220038131A KR20230139598A (ko) | 2022-03-28 | 2022-03-28 | O-아세틸 호모세린 생산 미생물 및 이를 이용한 o-아세틸 호모세린 또는 l-메치오닌 생산 방법 |
| PCT/KR2023/000276 WO2023191263A1 (ko) | 2022-03-28 | 2023-01-06 | O-아세틸 호모세린 생산 미생물 및 이를 이용한 o-아세틸 호모세린 또는 l-메치오닌 생산 방법 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP4491709A1 EP4491709A1 (de) | 2025-01-15 |
| EP4491709A4 true EP4491709A4 (de) | 2026-02-25 |
Family
ID=88203077
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP23781125.2A Pending EP4491709A4 (de) | 2022-03-28 | 2023-01-06 | O-acetyl-homoserin-produzierender mikroorganismus und verfahren zur herstellung von o-acetyl-homoserin oder l-methionin damit |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20250197899A1 (de) |
| EP (1) | EP4491709A4 (de) |
| JP (1) | JP7783437B2 (de) |
| KR (1) | KR20230139598A (de) |
| CN (1) | CN119278257A (de) |
| WO (1) | WO2023191263A1 (de) |
| ZA (1) | ZA202408012B (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20250133498A (ko) * | 2024-02-28 | 2025-09-08 | 경북대학교 산학협력단 | 디하이드로폴레이트 환원효소 활성 증가에 의한 l-메티오닌 생산능이 향상된 재조합 미생물 및 이를 이용한 l-메티오닌 생산 방법 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5981235A (en) | 1996-07-29 | 1999-11-09 | Promega Corporation | Methods for isolating nucleic acids using alkaline protease |
| JP4623825B2 (ja) | 1999-12-16 | 2011-02-02 | 協和発酵バイオ株式会社 | 新規ポリヌクレオチド |
| KR100620092B1 (ko) | 2004-12-16 | 2006-09-08 | 씨제이 주식회사 | 코리네박테리움 속 세포로부터 유래된 신규한 프로모터서열, 그를 포함하는 발현 카세트 및 벡터, 상기 벡터를포함하는 숙주 세포 및 그를 이용하여 유전자를 발현하는방법 |
| KR100905381B1 (ko) | 2006-07-28 | 2009-06-30 | 씨제이제일제당 (주) | Ｌ-메치오닌 전구체 생산 균주 및 상기 ｌ-메치오닌전구체로부터의 ｌ-메치오닌 및 유기산의 생산방법 |
| US8283152B2 (en) * | 2009-08-28 | 2012-10-09 | Cj Cheiljedang Corporation | Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism |
| ES2689754T3 (es) * | 2012-08-20 | 2018-11-15 | Evonik Degussa Gmbh | Procedimiento para la preparación fermentativa de L-aminoácidos utilizando cepas mejoradas de la familia Enterobacteriaceae |
| KR101825777B1 (ko) | 2014-06-05 | 2018-02-07 | 씨제이제일제당 (주) | O-아세틸-호모세린을 생산하는 미생물 및 이를 이용하여 o-아세틸-호모세린을 생산하는 방법 |
| KR101641770B1 (ko) | 2014-06-23 | 2016-07-22 | 씨제이제일제당 (주) | O-아세틸 호모세린을 생산하는 미생물 및 상기 미생물을 이용하여 o-아세틸 호모세린을 생산하는 방법 |
| KR101632642B1 (ko) | 2015-01-29 | 2016-06-22 | 씨제이제일제당 주식회사 | 신규한 프로모터 및 그의 용도 |
| KR101851452B1 (ko) * | 2016-07-18 | 2018-04-24 | 씨제이제일제당 (주) | O-아세틸-호모세린을 생산하는 미생물 및 이를 이용하여 o-아세틸-호모세린을 생산하는 방법 |
| RU2733425C1 (ru) | 2016-08-31 | 2020-10-01 | СиДжей ЧеилДжеданг Корпорейшн | Новый промотор и его применение |
| KR102011994B1 (ko) | 2017-06-30 | 2019-08-20 | 씨제이제일제당 주식회사 | 신규한 아스파토키나제 변이체 및 이를 이용한 l-아미노산의 제조방법 |
| JP6980819B2 (ja) | 2017-06-30 | 2021-12-15 | シージェイ チェイルジェダング コーポレイション | 新規なｏ−スクシニルホモセリントランスフェラーゼ変異体及びこれを用いたｏ−スクシニルホモセリンの製造方法 |
| CN108728502B (zh) | 2018-06-01 | 2021-11-30 | 江西师范大学 | 一种合成精氨酸的方法 |
| KR101996769B1 (ko) | 2018-12-21 | 2019-10-01 | 씨제이제일제당 (주) | 변이형 호모세린 디하이드로게나제 및 이를 이용한 호모세린 또는 호모세린 유래 l-아미노산의 생산 방법 |
| KR102182497B1 (ko) | 2019-12-20 | 2020-11-24 | 씨제이제일제당 주식회사 | 내막 단백질의 변이체 및 이를 이용한 목적 산물 생산 방법 |
| KR102278000B1 (ko) | 2020-03-17 | 2021-07-15 | 씨제이제일제당 주식회사 | 프리페네이트 디하이드라타아제 활성 강화를 통한 l-트립토판을 생산하는 방법 |
-
2022
- 2022-03-28 KR KR1020220038131A patent/KR20230139598A/ko not_active Ceased
-
2023
- 2023-01-06 EP EP23781125.2A patent/EP4491709A4/de active Pending
- 2023-01-06 US US18/851,660 patent/US20250197899A1/en active Pending
- 2023-01-06 CN CN202380043198.9A patent/CN119278257A/zh active Pending
- 2023-01-06 WO PCT/KR2023/000276 patent/WO2023191263A1/ko not_active Ceased
- 2023-01-06 JP JP2024557595A patent/JP7783437B2/ja active Active
-
2024
- 2024-10-23 ZA ZA2024/08012A patent/ZA202408012B/en unknown
Non-Patent Citations (3)
| Title |
|---|
| MIZUNO YUTA ET AL: "Altered acetylation and succinylation profiles in Corynebacterium glutamicum in response to conditions inducing glutamate overproduction", MICROBIOLOGYOPEN, vol. 5, no. 1, 11 December 2015 (2015-12-11), pages 152 - 173, XP093319793, ISSN: 2045-8827, DOI: 10.1002/mbo3.320 * |
| NAGANO-SHOJI MEGUMI ET AL: "Characterization of lysine acetylation of a phosphoenolpyruvate carboxylase involved in glutamate overproduction in Corynebacterium glutamicum.", MOLECULAR MICROBIOLOGY, vol. 104, no. 4, 20 March 2017 (2017-03-20), GB, pages 677 - 689, XP093319848, ISSN: 0950-382X, DOI: 10.1111/mmi.13658 * |
| See also references of WO2023191263A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA202408012B (en) | 2025-06-25 |
| EP4491709A1 (de) | 2025-01-15 |
| CN119278257A (zh) | 2025-01-07 |
| KR20230139598A (ko) | 2023-10-05 |
| JP7783437B2 (ja) | 2025-12-09 |
| JP2025510342A (ja) | 2025-04-14 |
| US20250197899A1 (en) | 2025-06-19 |
| WO2023191263A1 (ko) | 2023-10-05 |
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| RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12N 1/20 20060101AFI20260122BHEP Ipc: C12N 9/80 20060101ALI20260122BHEP Ipc: C12N 15/77 20060101ALI20260122BHEP Ipc: C12P 13/06 20060101ALI20260122BHEP Ipc: C12P 13/12 20060101ALI20260122BHEP Ipc: C12R 1/15 20060101ALI20260122BHEP |