EP4321254A1 - Centrifugeuse à courant parallèle - Google Patents

Centrifugeuse à courant parallèle Download PDF

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Publication number
EP4321254A1
EP4321254A1 EP22189564.2A EP22189564A EP4321254A1 EP 4321254 A1 EP4321254 A1 EP 4321254A1 EP 22189564 A EP22189564 A EP 22189564A EP 4321254 A1 EP4321254 A1 EP 4321254A1
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EP
European Patent Office
Prior art keywords
temperature control
line
rotor
temperature
flow centrifuge
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP22189564.2A
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German (de)
English (en)
Other versions
EP4321254A8 (fr
Inventor
Eckhard Tödteberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sartorius Stedim North America Inc
Original Assignee
Sigma Laborzentrifugen GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Laborzentrifugen GmbH filed Critical Sigma Laborzentrifugen GmbH
Priority to EP22189564.2A priority Critical patent/EP4321254A1/fr
Priority to PCT/EP2023/071664 priority patent/WO2024033257A1/fr
Publication of EP4321254A1 publication Critical patent/EP4321254A1/fr
Publication of EP4321254A8 publication Critical patent/EP4321254A8/fr
Pending legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B15/00—Other accessories for centrifuges
    • B04B15/02—Other accessories for centrifuges for cooling, heating, or heat insulating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B04B2005/0492—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with fluid conveying umbilicus between stationary and rotary centrifuge parts

Definitions

  • the invention relates to a flow centrifuge in which at least one medium (in particular a fluid, a liquid, a suspension, etc.) is supplied to a centrifugation chamber at least temporarily and/or a medium is removed from the centrifugation chamber while the centrifugation chamber rotates.
  • the medium can be arranged in a container in the centrifugation chamber.
  • the at least one medium is in particular the medium to be centrifuged, a rinsing liquid, a washing or buffer solution, a modified medium extracted from the centrifuged medium and/or a sediment in the centrifugation chamber.
  • the flow centrifuge may be a blood centrifuge in which the medium to be centrifuged is blood and the extracted modified medium or sediment is blood bodies or particles, or it may be a flow centrifuge, by means of which cells, microcarriers or other particles contained in the medium are to be obtained from a medium. It is also possible that the centrifuged medium is not a pure liquid, but rather the medium is a solution or suspension with particles such as cells, cell debris or parts, etc.
  • the flow centrifuge is used, for example, for the production of biopharmaceutical products in biopharmaceutical companies or in bio-processing applications.
  • the flow centrifuge can be used, for example, to obtain and/or clarify the cells or microcarriers, whereby the cells obtained in this way can also be used for cell therapy.
  • Another area of application for the flow centrifuge is, for example, the production of vaccines.
  • a rotor of the flow centrifuge has four centrifugation chambers, which can be designed as blood bags held on a rotor body and are evenly distributed over the circumference.
  • the centrifugation chambers are arranged at equal radial distances from the axis of rotation of the rotor.
  • a first connection line opens into a centrifugation chamber radially on the inside, while a second connection line opens into the centrifugation chamber on the radial outside.
  • a first medium for example blood
  • the centrifugation chamber rotates with the rotor.
  • particles contained in the blood e.g.
  • the first connecting line is a discharge line
  • the second connecting line is a supply line.
  • the proportion of particles and their concentration in the centrifugation chamber increases until it is largely and finally completely filled with the particles.
  • the particles are washed in the centrifugation chamber. For this purpose, a washing or buffer solution is fed into the centrifugation chamber via the second connection line.
  • the washing or buffer solution flushes through the centrifugation chamber and is discharged radially on the inside via the first connection line.
  • the centrifugation chamber rotates with the rotor, so that as a result of the centrifugation force acting, the particles are prevented from leaving the centrifugation chamber with the washing or buffer solution via the first connecting line to exit.
  • the first connection line serves as a discharge line for the washing or buffer solution
  • the first connection line serves as a supply line for the washing or buffer solution.
  • the centrifugation chamber continues to be rotated with the rotor.
  • the direction of flow through the centrifugation chamber is reversed and the particles are removed from the centrifugation chamber via the second connection line, while washing or buffer solution can be fed into the centrifugation chamber via the first connection line.
  • the third operating phase ends when all particles have been removed from the centrifugation chamber. This can be successively followed by further cycles with the three operating phases explained.
  • EP 3 936 601 A1 The design of a medium network can be seen, which is connected to the connection lines and ensures the different operating phases. With regard to this medium network, the included pump arrangement, the process control unit, an additional filter arrangement, receptacles for the different media and with regard to the process flow, additional information is provided EP 3 936 601 A1 , EP 2 310 486 B1 and EP 2 485 846 B1 referred.
  • EP 2 485 846 B1 describes that in flow centrifuges, fluidic connections to connection lines rotating with the rotor using rotary unions are problematic, since the rotary unions are susceptible to leaks and carry the risk of undesirable contamination of the media.
  • Connecting strands can be used in which the connecting cables can be integrated. One end region of the connecting strand is arranged fixed to the housing, while the other end region of the connecting strand is attached to the rotor and is rotated with the rotor.
  • the connecting strand is additionally guided in a guide device designed as a guide tube.
  • the guide tube has a section that has the shape of a rounded U with slightly spread side legs of different lengths. The opening of the U points in the direction of the rotation axis of the rotor. Starting from the end region fixed to the housing, the connecting strand enters a side leg of the U while curving outwards. In the U-shaped section, the connecting strand passes through the guide tube around the rotor shown around.
  • the invention is based on the object of improving a flow centrifuge in terms of ensuring predetermined operating conditions.
  • the invention relates to a flow centrifuge.
  • the flow centrifuge has a rotor that has (at least) one centrifugation chamber.
  • the medium to be centrifuged can be arranged in the centrifugation chamber directly or in a suitable container and this can be flushed with other media such as a washing or buffer solution.
  • the rotor is rotated around the rotor axis at a rotor speed.
  • the flow centrifuge has a connecting cable.
  • the connecting strand has a connecting line via which a medium can be supplied to the centrifugation chamber (in particular a container arranged in the centrifugation chamber) during operation of the flow centrifuge with a rotating rotor.
  • the connecting strand has a connecting line via which a medium can be removed from the centrifugation chamber (in particular a container arranged in the centrifugation chamber).
  • a medium can be removed from the centrifugation chamber (in particular a container arranged in the centrifugation chamber).
  • the flow directions through the connection lines can be reversed.
  • One end region of the connecting strand is arranged fixed to the housing, while the other end region of the connecting strand is twisted with the rotor.
  • the connecting strand is guided in a guide device, in particular a guide tube.
  • the guide device is rotated around the rotor axis at half the rotor speed.
  • the flow centrifuge can, for example, be designed like the flow centrifuges of the prior art mentioned at the beginning.
  • rotor chamber temperature control circuits are used in flow centrifuges.
  • the rotor chamber temperature control circuit usually has a rotor chamber temperature control loop integrated into a wall of a bowl of the flow centrifuge, which is in heat exchange with the rotor chamber in which the rotor is rotated.
  • a temperature sensor which may also be integrated into the boiler of the rotor chamber, records the temperature in the rotor chamber.
  • the temperature control output of the rotor chamber temperature control circuit can then be regulated in such a way that the temperature in the rotor chamber is kept as constant as possible, which means, according to the prior art, that it is assumed that the medium to be centrifuged also has a constant temperature .
  • the considerations underlying the invention initially dealt with the causes of a change in temperatures in a flow centrifuge.
  • One cause of heating of the interior of the rotor chamber is that the air arranged in the rotor chamber is accelerated and swirled as a result of the rotational movement of the rotor, which can lead to heating of the air.
  • heat can be introduced into the rotor chamber from a centrifuge drive or as a result of friction, for example in the bearings of a rotor shaft. This heating can be counteracted using the known rotor chamber temperature control circuit.
  • the connecting strand as a result of its boundary conditions, namely the fixed connection of one end region to the housing, the rotation of the other end region with the rotor and the guidance of the connecting strand by means of the guide device, which is rotated around the rotor axis at half the rotor speed, is deformed is, which in particular leads to flexing work in the connecting strand, which leads to heating of the connecting strand. Furthermore, the friction of the connecting strand with the guide device can lead to heating of the connecting strand.
  • the invention proposes that in the flow centrifuge according to the invention, a temperature control supply line and a temperature control discharge line extend through the connecting line.
  • a connecting line temperature control fluid flows through the temperature control supply line and the temperature control discharge line in opposite flow directions.
  • the temperature control supply line and the temperature control discharge line are therefore in particular part of a connecting strand temperature control circuit, via which cooling can be specifically brought about in the area of the connecting strand, which ideally compensates for the heat generated as a result of the flexing work and friction in the area of the connecting strand.
  • an increase in temperature can be counteracted directly at the location where it occurs. This means that in the flow centrifuge, namely in the area of the connecting line, the operating conditions, here the temperature, can be maintained exactly or within predetermined temperature ranges.
  • the temperature control supply line, the temperature control discharge line and the connection lines can be arranged distributed anywhere over the cross section of the connecting line, for example next to one another or one above the other.
  • the temperature control supply line, the temperature control discharge line and the connection lines are arranged distributed in a cross section of the connecting strand in the circumferential direction around a longitudinal axis of the connecting strand, These preferably lie directly on an adjacent line when viewed in the circumferential direction.
  • the order in which the lines mentioned are arranged in the circumferential direction is basically arbitrary.
  • the temperature control supply line, the temperature control discharge line and the connecting lines are arranged in a cross section of the connecting strand in the circumferential direction distributed around the longitudinal axis of the connecting strand so that in both circumferential directions around the longitudinal axis between the temperature control supply line and the temperature control -Discharge line at least one connection line is arranged.
  • the at least one connection line is arranged "sandwich-like" between the temperature control supply line and the temperature control discharge line, so that the at least one connection line is in heat exchange with both the temperature control supply line and with the temperature control discharge line. This enables particularly good heat transfer between the temperature control lines and the connecting lines.
  • the temperature control supply line and the temperature control discharge line are connected to one another via a reversal connection.
  • the reversal connection can be designed as a U-shaped connecting piece.
  • one leg of the U can be connected to an end region of the temperature control supply line, while the other leg of the U can be connected to the end region of the temperature control discharge line.
  • These connections can be made, for example, by the respective leg being inserted into the temperature control line and secured in the temperature control line (for example by a positive and/or frictional connection or jamming; in some cases also with the interposition of a seal or a sealant), whereby It is also possible for the temperature control line and the leg of the connecting piece to be plastically pressed together.
  • the reversal connection is preferably connected in the end region of the connecting strand and the temperature control lines that is twisted with the rotor. The reversal connection ensures the opposite flow through the temperature control lines.
  • the connecting strand has a flexible pipe or a flexible hose.
  • the temperature control supply line, the temperature control discharge line and the connecting lines extend through the flexible pipe or flexible hose.
  • the pipe or hose can ensure a smooth outer surface to keep the turbulence in the rotor chamber small. Non-smooth external geometries of the pipe are also possible or hose, for example a flexible corrugated pipe can also be used.
  • the flexible pipe or flexible hose keeps the temperature control lines and the connection lines in a compact state and also ensures protection of the temperature control lines and the connection lines. It is also possible for the hose or pipe to be used to thermally encapsulate the connecting strand.
  • the temperature control supply line and the temperature control discharge line only extend from the housing over a part of the longitudinal extent of the connecting strand, this longitudinal extent preferably coinciding with the area of the connecting strand in which the previously explained flexing work and/or friction occurs.
  • the reversal connection it is possible for the reversal connection to be arranged at the end of the extension of the temperature control lines, with the result that the reversal connection or the U-shaped connecting piece is arranged inside the connecting strand, in particular inside the flexible pipe or flexible hose.
  • the reversal connection is arranged in the exit area of the temperature control supply line and the temperature control discharge line from the flexible pipe or hose, so that the temperature control lines extend over the entire length of the connecting strand.
  • the arrangement of the reversal connection in the outlet area then uses a larger installation space available outside the pipe or hose.
  • the reversal connection is U-shaped.
  • the U-shaped reversal connection can at least partially enclose at least one connection line.
  • the connection line is angled outwards from the pipe or hose.
  • the exit area and the bend can be arranged at least partially inside the U of the U-shaped reversal connection, which makes additional guidance and/or protection as well as a position specification of at least one connection line possible.
  • the partial enclosing of the connection line by the reversal connection leads to a particularly compact design.
  • the electrical line can be any measuring line, an electrical supply line for a sensor arranged in the rotor or attached to the rotor, an electrical control line for a valve of the rotor and the like.
  • a control or regulation in the connecting line temperature control circuit can be carried out in any way and taking into account any signals from temperature sensors, flow sensors and / or taking into account any operating parameters of the flow centrifuge (speed, outside temperature, internal temperature, design and / or equipment of the rotor; Centrifugation program and parameters, ).
  • the temperature of the connecting line temperature control fluid and/or the flow (in particular the mass flow and/or volume flow) of the connecting line temperature control fluid is controlled or regulated, taking into account a temperature of the medium which is located in at least one connection line and/ or is promoted by them.
  • the control or regulation is preferably carried out taking into account a temperature difference in the connecting lines.
  • the temperature difference provides information about the medium supplied between the two measuring points Warmth.
  • greater cooling power is required, which can be provided by controlling or regulating the temperature and/or flow of the connecting line temperature control fluid.
  • control or regulation can be carried out with the aim of ensuring that the temperature difference is zero or is below a threshold value.
  • At least one sensor for detecting the temperature or both sensors for detecting the temperature difference can also be arranged in the housing in the assigned end region of the connecting cable(s) and thus in a stationary manner.
  • the flow centrifuge has at least one electronic control unit, whereby in the case of several electronic control units, the control units can be connected or networked with one another.
  • the electronic control unit has control logic by means of which the connecting line temperature control performance of the connecting line temperature control circuit is controlled or regulated.
  • a rotor chamber temperature control circuit is also present in the flow centrifuge.
  • the rotor chamber temperature control circuit is preferably arranged in a stationary manner, in particular with a cooling loop integrated into the wall of the boiler.
  • the connecting line temperature control circuit on the one hand and the rotor chamber temperature control circuit on the other hand are fluidly independent of one another, in which case the circuits can be coordinated via at least one control unit.
  • the same temperature control fluid can be used.
  • the same pressure source in particular a pump or a pressure vessel, is used to provide the flow of the temperature control fluid through the two temperature control circuits.
  • the invention also proposes that an electronic control unit is present which has control logic that controls or regulates the rotor chamber temperature control performance of the rotor chamber temperature control circuit.
  • This electronic control unit can be designed separately from the control unit of the connecting line temperature control circuit or these can be combined to form an overall control unit.
  • a temperature sensor is present which detects the temperature of a rotor chamber (directly or indirectly).
  • the temperature sensor can be integrated into a wall of the vessel, a lid, etc. of the flow centrifuge or protrude from there into the rotor chamber or adjoin the rotor chamber. It is also possible for the temperature sensor to be arranged on the rotor and rotate with it.
  • the temperature sensor is preferably arranged in a flow-calmed area of the interior of the rotor chamber.
  • the control logic regulates the rotor chamber temperature control circuit taking into account a temperature signal from the temperature sensor, with regulation preferably taking place to a desired temperature value. Any control strategy can be used here.
  • control logics are, on the one hand, the control or regulation of the rotor chamber temperature control performance of the rotor chamber temperature control circuit and, on the other hand the control or regulation of the connecting line temperature control performance of the connecting line temperature control circuit is not independent of one another, but rather coordinated with one another. This can mean, for example, that an increase in the rotor chamber temperature control power is automatically coupled by the control logic with an increase in the connecting line temperature control power.
  • control logic it is also possible for the control logic to ensure that the sum of the rotor chamber temperature control performance on the one hand and the connecting line temperature control performance on the other hand remains constant, does not fall below and/or exceeds a threshold value or corresponds to a characteristic map or a curve that depends on the operating parameters.
  • this takes into account a heat capacity of the media that flow through the connecting lines for the control or regulation of the connecting line temperature control power.
  • a heat capacity of the media that flow through the connecting lines for the control or regulation of the connecting line temperature control power.
  • the medium on the one hand and the rinsing or buffer solution on the other hand can have different heat capacities.
  • the simplifying assumption which serves only as an explanation, that the same heat is absorbed by the media per time, the heat absorption in the medium with the higher heat capacity then leads to a smaller temperature change than in the medium with the lower heat capacity.
  • a different amplification factor of the temperature difference must be taken into account for determining the signal for controlling or regulating the connecting line temperature control power.
  • the rotor speed can also be taken into account in the control or regulation of the connecting line temperature control power, since the flexing work in the connecting line is dependent on the rotor speed.
  • Fig. 1 shows a highly schematized flow centrifuge 1 in a spatial representation in a semi-longitudinal section.
  • the flow centrifuge 1 has a housing 2 and in particular a boiler 3 with a wall 4.
  • the wall 4 of the boiler 3 delimits a rotor chamber 5, in which a rotor 6 is rotated about a rotor axis 7 at a rotor speed.
  • the rotor 6 is shown in the schematic representation Fig. 1 Only containers 8a, 8b arranged in the centrifugation chamber of the rotor 6 (here two containers 8a, 8b, although any other number of containers 8 can also be present) are shown, which can be, for example, blood bags 9 or any other containers.
  • the containers 8 are arranged evenly distributed in the circumferential direction around the rotor axis 7 and are at the same distance from the rotor axis 7.
  • the flow centrifuge 1 has a rotor chamber temperature control circuit 10, of which in Fig. 1 only a rotor chamber temperature control loop 11 is shown.
  • the rotor chamber temperature control loop 11 is integrated into the wall 4 of the boiler 3 and winds with several turns around the rotor axis 7 and the rotor chamber 5.
  • a connecting strand 12 can also be seen.
  • the connecting strand 12 has a flexible hose or a flexible tube 13. Extending through the hose or pipe 13 are a temperature control supply line 14, a temperature control discharge line 15 (which is also referred to together with the term "temperature control line”) and two connecting lines 16, 17, which are used in the different operating phases of the Centrifugation process flows through in different directions.
  • the connecting strand 12 is attached to the housing 2 or a wall 4 of the boiler 3, while in another end region 19 the connecting strand 12 is attached to the rotor 6 and is rotated with it.
  • the guide device in particular a guide tube, rotating at half the rotor speed is shown in the schematic Fig. 1 not shown (cf. the prior art mentioned at the beginning).
  • Fig. 2 shows a detail according to II Fig. 1 .
  • the end region 19 of the connecting strand 12 can be seen as well as the exit of the temperature control lines 14, 15 from the hose or pipe 13 and their connection to the containers 8a, 8b.
  • the containers 8a, 8b are each connected to individual connection lines 17a, 17b, through which the medium flows in the same direction, while the containers 8a, 8b are responsible for the flow of the medium in the other direction a common connection line 16 are connected.
  • the flow through the connecting line 17a, 17b can be controlled or regulated individually or differently via a valve or switching device, a specific and different application of the medium to the containers 8a, 8b can be controlled.
  • only a single container 8a, 8b can be filled or removal of centrifuged sediments from the containers 8a, 8b can be started and/or ended at different times.
  • the connecting line 16 is connected via a branch 20 to two connecting lines 21a, 21b, which in turn are each connected to an associated container 8a, 8b.
  • the connecting lines 17a, 17b are directly connected to the assigned container via assigned connecting lines 22a, 22b 8a, 8b connected.
  • the temperature control lines 14, 15 are connected to one another immediately adjacent to the end of the pipe or hose 13 via a reversal connection 23, which is designed here as a U-shaped connecting piece 24.
  • the bends and transition areas between the connecting lines 16, 17 and the connecting lines 21, 22 extend through the interior of the U-shaped connecting piece 24. This results in the reversal connection 23 at least partially enclosing at least one connecting line 16, 17.
  • the U-shaped connecting piece 24 can also ensure that the bends and the connecting lines 21, 22 are fixed in position.
  • Fig. 3 shows a cross section of the connecting strand 12.
  • the temperature control lines 14, 15 and the connecting lines 16, 17a, 17b are arranged distributed on a circular arc in the circumferential direction and lie directly against one another in the circumferential direction and radially on the outside on the inner surface of the pipe or hose 13 concerns.
  • the order in the circumferential direction is preferably selected such that at least one connecting line 16, 17 is arranged between the temperature control lines 14, 15 in both circumferential directions.
  • the connection line 16 is arranged in one circumferential direction between the temperature control lines 14, 15, while in the other circumferential direction the two connection lines 17a, 17b are arranged between the temperature control lines 14, 15.
  • Fig. 4 Only four lines, namely the temperature control lines 14, 15 and the connecting lines 16, 17, are arranged in the cross section.
  • the connecting lines 16, 17 can each have a branch to the different containers 8a, 8b. It goes without saying that, using a different design of branches and/or a different number of lines, more than two containers 8 can also be present in the rotor 6 and can be supplied with the different media.
  • Fig. 5 shows schematically a control device of a flow centrifuge 1:
  • the rotor chamber temperature control circuit 10 has a supply unit 25 in which the rotor chamber temperature control fluid is supplied in a controlled or regulated manner with the required Flow and the required temperature is provided.
  • the rotor chamber temperature control fluid is then supplied in a closed circuit to the rotor chamber temperature control loop 11, which can be integrated into a wall 4 of the rotor chamber 5.
  • a temperature sensor 26 detects the temperature in the rotor chamber 5, the temperature sensor 26 preferably being integrated into the wall 4 of the rotor chamber 5 or being held on it.
  • the measurement signal from the temperature sensor 26 is fed to an electronic control unit 28 via a sensor signal connection 27.
  • the control unit 28 has control logic which produces a control or regulation signal in a control line 29 for activating the supply unit 25 to ensure the regulated flow with the regulated temperature of the rotor chamber temperature control fluid.
  • a centrifugation media circuit 30 has a provision unit 31, which ensures the different operating phases mentioned above in the centrifugation media circuit 30 and the media, in particular the medium to be centrifuged as well as a rinsing or buffer solution, with the required flows and the flow directions in the different provides operational phases.
  • a temperature sensor 32, 33 is arranged in the end region 18 of the connecting lines 16, 17 of the centrifugation media circuit 30, which detects the temperature of the media supplied to the centrifugation chamber or the containers 8 and of the media removed. The temperature signals from the temperature sensors 32, 33 are transmitted to the control unit 28 via sensor signal connections 34, 35.
  • the control unit 28 has control logic which determines a temperature difference from the temperature signals from the temperature sensors 32, 33, which, as will be explained below, is used for control or regulation purposes of the connecting line temperature control circuit 36.
  • the control unit 28 controls or regulates the provision unit 31 via a control line 37 to ensure the required flows and the different operating phases.
  • connection line temperature control fluid is provided by means of a provision unit 38.
  • the control unit 28 controls the provision unit 38 via a control line 39 in such a way that the connection line temperature control fluid circulating in the temperature control lines 14, 15 provides the desired cooling capacity.
  • the provision unit 38 is preferably regulated by the control unit 28 based on the temperature difference of the temperature signals from the temperature sensors 32, 33.
  • Fig. 5 is just a very schematic representation, with individual ones listed separately Fig. 5 Components shown can actually be combined into one component. This can already be seen from the fact that the connecting line temperature control circuit 36 with the temperature control lines 14, 15 are shown separately from the rotor chamber 5, although the temperature control lines 14, 15 extend into the rotor chamber 5. It is possible that the two temperature control circuits 10, 36 differ Fig. 5 are not designed separately, but rather a fluidic coupling of the two circuits 10, 36 is present. A single common supply unit can thus provide the same temperature control fluid for the rotor chamber temperature control circuit 10 and the connecting line temperature control circuit 36, with the flows and temperatures in the two circuits 10, 36 then being ensured via suitable throttle devices, valves or other fluidic components.
  • control in the connecting line temperature control circuit 36 can also take place on the basis of a temperature sensor that is integrated into the connecting line 12.
  • the sensor signal connections 27, 34, 35 explained can be wired or wireless connections. It is also possible for the sensor signals to be provided via a bus system. The same applies to the control lines 29, 37, 39.
  • a control unit 28 which here ensures the control or regulation of the rotor chamber temperature control circuit 10, the centrifugation media circuit 30 and the connecting line temperature control circuit 36. It is possible that these tasks are carried out by several control units, which can then be connected or networked with one another.
  • the heat generated as a result of the flexing work and thus the cooling power to be provided by the connecting line temperature control circuit can, for example, be a maximum of 50 watts to 200 watts, in particular 0 watts to 150 watts. If the medium to be centrifuged is blood, a threshold temperature that should not be exceeded can be, for example, 37 ° C.
  • the medium to be centrifuged is conveyed through the connecting lines in one operating phase and a flushing fluid is conveyed through the connecting lines in another operating phase.
  • Different control or regulation can be carried out for the different operating phases.
  • the processing of a temperature difference measured in the connecting lines can take place differently or with different amplification factors.

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  • Centrifugal Separators (AREA)
EP22189564.2A 2022-08-09 2022-08-09 Centrifugeuse à courant parallèle Pending EP4321254A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP22189564.2A EP4321254A1 (fr) 2022-08-09 2022-08-09 Centrifugeuse à courant parallèle
PCT/EP2023/071664 WO2024033257A1 (fr) 2022-08-09 2023-08-04 Centrifugeuse à écoulement continu

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP22189564.2A EP4321254A1 (fr) 2022-08-09 2022-08-09 Centrifugeuse à courant parallèle

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EP4321254A1 true EP4321254A1 (fr) 2024-02-14
EP4321254A8 EP4321254A8 (fr) 2024-04-03

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EP (1) EP4321254A1 (fr)
WO (1) WO2024033257A1 (fr)

Citations (12)

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US4216770A (en) 1979-02-09 1980-08-12 Baxter Travenol Laboratories, Inc. Sickle cell therapeutic treatment
WO1980002653A1 (fr) * 1979-06-06 1980-12-11 Gambro Ab Dispositif de separation d'un liquide en fractions, specialement de sang entier
US4389206A (en) 1980-10-09 1983-06-21 Baxter Travenol Laboratories, Inc. Centrifugal processing apparatus and rotatable processing bowl apparatus
US4419089A (en) 1977-07-19 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Blood cell separator
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EP3936601A1 (fr) 2020-07-06 2022-01-12 Sartorius Stedim Biotech GmbH Configuration de clarification d'une installation de biotraitement

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EP2485846B1 (fr) 2009-10-06 2019-07-17 Sartorius Stedim North America Inc. Procédés, systèmes et appareil de manipulation de particules
EP3936601A1 (fr) 2020-07-06 2022-01-12 Sartorius Stedim Biotech GmbH Configuration de clarification d'une installation de biotraitement

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