EP4311577A3 - Composés inhibiteurs de métalloenzymes - Google Patents
Composés inhibiteurs de métalloenzymes Download PDFInfo
- Publication number
- EP4311577A3 EP4311577A3 EP23212447.9A EP23212447A EP4311577A3 EP 4311577 A3 EP4311577 A3 EP 4311577A3 EP 23212447 A EP23212447 A EP 23212447A EP 4311577 A3 EP4311577 A3 EP 4311577A3
- Authority
- EP
- European Patent Office
- Prior art keywords
- inhibitor compounds
- metalloenzyme inhibitor
- metalloenzyme
- compounds
- metalloenzymes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 229940125956 metalloenzyme inhibitor Drugs 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662440181P | 2016-12-29 | 2016-12-29 | |
| PCT/US2017/068190 WO2018125800A2 (fr) | 2016-12-29 | 2017-12-22 | Composés inhibiteurs des métalloenzymes |
| EP17887556.3A EP3562487B1 (fr) | 2016-12-29 | 2017-12-22 | Composés inhibiteurs des métalloenzymes |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP17887556.3A Division EP3562487B1 (fr) | 2016-12-29 | 2017-12-22 | Composés inhibiteurs des métalloenzymes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP4311577A2 EP4311577A2 (fr) | 2024-01-31 |
| EP4311577A3 true EP4311577A3 (fr) | 2024-04-17 |
Family
ID=62709109
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP23212447.9A Pending EP4311577A3 (fr) | 2016-12-29 | 2017-12-22 | Composés inhibiteurs de métalloenzymes |
| EP17887556.3A Active EP3562487B1 (fr) | 2016-12-29 | 2017-12-22 | Composés inhibiteurs des métalloenzymes |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP17887556.3A Active EP3562487B1 (fr) | 2016-12-29 | 2017-12-22 | Composés inhibiteurs des métalloenzymes |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10085984B2 (fr) |
| EP (2) | EP4311577A3 (fr) |
| JP (2) | JP7227157B2 (fr) |
| KR (1) | KR102690885B1 (fr) |
| CN (1) | CN110691598A (fr) |
| AU (2) | AU2017387033B2 (fr) |
| BR (1) | BR112019013478A2 (fr) |
| CA (1) | CA3055292A1 (fr) |
| DK (1) | DK3562487T3 (fr) |
| ES (1) | ES2967119T3 (fr) |
| FI (1) | FI3562487T3 (fr) |
| MX (2) | MX2019007892A (fr) |
| RU (1) | RU2764666C2 (fr) |
| TW (1) | TWI786078B (fr) |
| WO (1) | WO2018125800A2 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102061137B1 (ko) * | 2012-01-20 | 2019-12-31 | 마이코비아 파마슈티컬즈, 인코포레이티드 | 금속효소 억제제 화합물 |
| WO2018125799A2 (fr) | 2016-12-29 | 2018-07-05 | Viamet Pharmaceuticals (Bermuda), Ltd. | Composés inhibiteurs des métalloenzymes |
| EP3908319B1 (fr) * | 2019-01-08 | 2023-10-18 | Ji Xing Pharmaceuticals Hong Kong Limited | Composés inhibiteurs de métalloenzyme |
| GB201901757D0 (en) | 2019-02-08 | 2019-03-27 | Syngenta Crop Protection Ag | Herbicidal compounds |
| BR112022023550A2 (pt) | 2020-05-19 | 2023-01-03 | Bayer Cropscience Ag | (tio)amidas azabicíclicas como compostos fungicidas |
| US20230234945A1 (en) | 2020-06-10 | 2023-07-27 | Bayer Aktiengesellschaft | Azabicyclyl-substituted heterocycles as fungicides |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009156462A2 (fr) * | 2008-06-27 | 2009-12-30 | Novartis Ag | Composés organiques |
| WO2012012478A1 (fr) * | 2010-07-21 | 2012-01-26 | Merck Sharp & Dohme Corp. | Inhibiteurs de l'aldostérone synthase |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5087240A (en) | 1983-08-18 | 1992-02-11 | Drug Delivery Systems Inc. | Transdermal drug patch with conductive fibers |
| US4921475A (en) | 1983-08-18 | 1990-05-01 | Drug Delivery Systems Inc. | Transdermal drug patch with microtubes |
| US4738851A (en) | 1985-09-27 | 1988-04-19 | University Of Iowa Research Foundation, Inc. | Controlled release ophthalmic gel formulation |
| US5163899A (en) | 1987-03-20 | 1992-11-17 | Drug Delivery Systems Inc. | Transdermal drug delivery system |
| US5312325A (en) | 1987-05-28 | 1994-05-17 | Drug Delivery Systems Inc | Pulsating transdermal drug delivery system |
| GB8804164D0 (en) | 1988-02-23 | 1988-03-23 | Tucker J M | Bandage for administering physiologically active compound |
| US4882150A (en) | 1988-06-03 | 1989-11-21 | Kaufman Herbert E | Drug delivery system |
| US5008110A (en) | 1988-11-10 | 1991-04-16 | The Procter & Gamble Company | Storage-stable transdermal patch |
| US5088977A (en) | 1988-12-21 | 1992-02-18 | Drug Delivery Systems Inc. | Electrical transdermal drug applicator with counteractor and method of drug delivery |
| US5521222A (en) | 1989-09-28 | 1996-05-28 | Alcon Laboratories, Inc. | Topical ophthalmic pharmaceutical vehicles |
| DE69009946T2 (de) | 1989-12-04 | 1994-11-03 | Searle & Co | System zur transdermalen Albuterol Applikation. |
| US5106863A (en) | 1990-03-26 | 1992-04-21 | Ortho Pharmaceutical Corporation | Substituted imidazole and pyridine derivatives |
| US5077033A (en) | 1990-08-07 | 1991-12-31 | Mediventures Inc. | Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide |
| DK0495421T3 (da) | 1991-01-15 | 1996-12-09 | Alcon Lab Inc | Anvendelse af carragenaner i topiske ophthalmiske sammensætninger |
| US5352456A (en) | 1991-10-10 | 1994-10-04 | Cygnus Therapeutic Systems | Device for administering drug transdermally which provides an initial pulse of drug |
| JPH07502219A (ja) | 1991-12-18 | 1995-03-09 | ミネソタ マイニング アンド マニュファクチャリング カンパニー | 多重層型バリアー構造体 |
| ATE132381T1 (de) | 1992-01-29 | 1996-01-15 | Voelkl Franz Ski | Ballspielschläger, insbesondere tennisschläger |
| IL114193A (en) | 1994-06-20 | 2000-02-29 | Teva Pharma | Ophthalmic pharmaceutical compositions based on sodium alginate |
| ES2094688B1 (es) | 1994-08-08 | 1997-08-01 | Cusi Lab | Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion. |
| IT1283911B1 (it) | 1996-02-05 | 1998-05-07 | Farmigea Spa | Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo |
| US5800807A (en) | 1997-01-29 | 1998-09-01 | Bausch & Lomb Incorporated | Ophthalmic compositions including glycerin and propylene glycol |
| US6261547B1 (en) | 1998-04-07 | 2001-07-17 | Alcon Manufacturing, Ltd. | Gelling ophthalmic compositions containing xanthan gum |
| US6197934B1 (en) | 1998-05-22 | 2001-03-06 | Collagenesis, Inc. | Compound delivery using rapidly dissolving collagen film |
| IL161576A0 (en) | 2001-10-26 | 2004-09-27 | Aventis Pharma Inc | Benzimidazoles and analogues and their use as protein kinases inhibitors |
| EP1474425B9 (fr) * | 2002-01-07 | 2008-07-02 | Eisai Co., Ltd. | Deazapurines et leurs utilisations |
| JP2006520796A (ja) | 2003-03-17 | 2006-09-14 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼインヒビター |
| EP1604988A1 (fr) * | 2004-05-18 | 2005-12-14 | Sanofi-Aventis Deutschland GmbH | Dérivés de pyridazinone, méthodes de leur préparation et leur utilisation comme pharmaceutiques |
| KR101099303B1 (ko) | 2005-01-28 | 2011-12-26 | 주식회사 대웅제약 | 신규한 벤조이미다졸 유도체 및 이를 함유하는 약제학적조성물 |
| UY29825A1 (es) * | 2005-10-03 | 2007-05-31 | Astrazeneca Ab | Derivados sustituidos de 3h-imidazol-(4,5 b (beta))piridina-2-il benzoatos y benzamidas, composiciones farmacéuticas que los contienen y aplicaciones |
| ES2274712B1 (es) | 2005-10-06 | 2008-03-01 | Laboratorios Almirall S.A. | Nuevos derivados imidazopiridina. |
| US20080027044A1 (en) | 2006-06-13 | 2008-01-31 | Kim Lewis | Prodrug antibiotic screens |
| EP1878724A1 (fr) | 2006-07-15 | 2008-01-16 | sanofi-aventis | Synthèse régiosélective des benzimidazoles et azabenzimidazoles catalysée par le palladium |
| JP2010524892A (ja) | 2007-04-19 | 2010-07-22 | ノバルティス アーゲー | 代謝型グルタミン酸受容体−５の修飾因子としてのニコチン酸誘導体 |
| US7737175B2 (en) | 2007-06-01 | 2010-06-15 | Duke University | Methods and compositions for regulating HDAC4 activity |
| CN101687815A (zh) | 2007-06-26 | 2010-03-31 | 塞诺菲-安万特股份有限公司 | 苯并咪唑和氮杂苯并咪唑的区域选择性铜催化合成 |
| CA2701115A1 (fr) | 2007-10-04 | 2009-04-09 | Merck Sharp & Dohme Corp. | Composes n-hydroxy-naphtalene dicarboxamide et n-hydroxy-biphenyl-dicarboxamide comme inhibiteurs de l'histone desacetylase |
| EP2254572B1 (fr) | 2008-02-07 | 2013-10-16 | Massachusetts Eye & Ear Infirmary | Composés stimulant l expression du gène atoh-1 |
| GB0821994D0 (en) | 2008-12-02 | 2009-01-07 | Ge Healthcare Ltd | In viva imaging method |
| BRPI1010600A2 (pt) | 2009-05-15 | 2016-03-15 | Novartis Ag | aril piridina como inibidores de aldosterona sintase |
| EP2993169B1 (fr) | 2009-11-17 | 2017-12-20 | Novartis AG | Dérivés de l'arylpyridine comme inhibiteurs de l'aldosterone synthase |
| WO2012045804A1 (fr) | 2010-10-08 | 2012-04-12 | Vib Vzw | Inhibiteurs des hdac pour traiter l'amyotrophie péronière de charcot-marie-tooth |
| US8815854B2 (en) | 2011-06-24 | 2014-08-26 | Arqule, Inc. | Substituted imidazopyridinyl compounds |
| WO2013033901A1 (fr) * | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Dérivés benzofuranes substitués par un hétérocycle et leurs procédés d'utilisation pour le traitement de maladies virales |
| CN103626783B (zh) * | 2012-08-22 | 2016-06-08 | 中国科学院上海药物研究所 | 双环稠杂环化合物及其用途和药物组合物 |
| WO2014179303A1 (fr) | 2013-04-29 | 2014-11-06 | The General Hospital Corporation | Bloqueurs de l'arn messager de protéine précurseur de l'amyloïde permettant de traiter le syndrome de down et la maladie d'alzheimer |
| MY176401A (en) | 2014-04-24 | 2020-08-05 | Mitsubishi Tanabe Pharma Corp | Novel disubstituted 1,2,4-triazine compound |
| WO2015188369A1 (fr) | 2014-06-13 | 2015-12-17 | Merck Sharp & Dohme Corp. | Inhibiteurs puriques de la phosphatidylinositol 3-kinase delta humaine |
| EP3558984B1 (fr) | 2016-12-20 | 2023-08-02 | FMC Corporation | Oxadiazoles à activité fongicide |
| WO2018125799A2 (fr) | 2016-12-29 | 2018-07-05 | Viamet Pharmaceuticals (Bermuda), Ltd. | Composés inhibiteurs des métalloenzymes |
-
2017
- 2017-12-22 RU RU2019123854A patent/RU2764666C2/ru active
- 2017-12-22 BR BR112019013478-6A patent/BR112019013478A2/pt active Search and Examination
- 2017-12-22 JP JP2019556790A patent/JP7227157B2/ja active Active
- 2017-12-22 AU AU2017387033A patent/AU2017387033B2/en active Active
- 2017-12-22 WO PCT/US2017/068190 patent/WO2018125800A2/fr unknown
- 2017-12-22 CN CN201780087610.1A patent/CN110691598A/zh active Pending
- 2017-12-22 DK DK17887556.3T patent/DK3562487T3/da active
- 2017-12-22 EP EP23212447.9A patent/EP4311577A3/fr active Pending
- 2017-12-22 EP EP17887556.3A patent/EP3562487B1/fr active Active
- 2017-12-22 MX MX2019007892A patent/MX2019007892A/es unknown
- 2017-12-22 FI FIEP17887556.3T patent/FI3562487T3/fi active
- 2017-12-22 KR KR1020197022285A patent/KR102690885B1/ko active IP Right Grant
- 2017-12-22 ES ES17887556T patent/ES2967119T3/es active Active
- 2017-12-22 CA CA3055292A patent/CA3055292A1/fr active Pending
- 2017-12-29 US US15/857,950 patent/US10085984B2/en active Active
- 2017-12-29 TW TW106146533A patent/TWI786078B/zh active
-
2018
- 2018-09-07 US US16/124,846 patent/US11040034B2/en active Active
-
2019
- 2019-06-28 MX MX2022012386A patent/MX2022012386A/es unknown
-
2021
- 2021-06-17 US US17/350,726 patent/US20210322409A1/en active Pending
-
2023
- 2023-02-09 JP JP2023018482A patent/JP2023071692A/ja active Pending
-
2024
- 2024-05-01 AU AU2024202860A patent/AU2024202860A1/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009156462A2 (fr) * | 2008-06-27 | 2009-12-30 | Novartis Ag | Composés organiques |
| WO2012012478A1 (fr) * | 2010-07-21 | 2012-01-26 | Merck Sharp & Dohme Corp. | Inhibiteurs de l'aldostérone synthase |
Non-Patent Citations (4)
| Title |
|---|
| GÖKER, H. ET AL.: "Synthesis and potent antifungal activity against Candida species of some novel 1H-benzimidazoles", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 46, no. 5, 2009, pages 936 - 948, XP002596734, ISSN: 0022-152X, DOI: 10.1002/JHET.179 * |
| HOYT, S.B. ET AL.: "Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys", ACS MEDICINAL CHEMISTRY LETTERS, vol. 6, no. 5, 2015, pages 573 - 578, XP055534685, ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.5b00054 * |
| MEREDITH, E.L. ET AL.: "Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors", ACS MEDICINAL CHEMISTRY LETTERS, vol. 4, no. 12, 2013, pages 1203 - 1207, XP002755995, ISSN: 1948-5875, [retrieved on 20131017], DOI: 10.1021/ML400324C * |
| PAPILLON, J.P.N. ET AL.: "Discovery of N -[5-(6-Chloro-3-cyano-1-methyl-1 H -indol-2-yl)-pyridin-3-ylmethyl]-ethanesulfonamide, a Cortisol-Sparing CYP11B2 Inhibitor that Lowers Aldosterone in Human Subjects", JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, no. 23, 2015, pages 9382 - 9394, XP055715085, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.5b01545 * |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2764666C2 (ru) | 2022-01-19 |
| MX2019007892A (es) | 2020-02-05 |
| BR112019013478A2 (pt) | 2020-01-07 |
| JP2020510693A (ja) | 2020-04-09 |
| JP7227157B2 (ja) | 2023-02-21 |
| KR102690885B1 (ko) | 2024-08-02 |
| US20210322409A1 (en) | 2021-10-21 |
| EP3562487A2 (fr) | 2019-11-06 |
| AU2017387033B2 (en) | 2024-02-01 |
| CN110691598A (zh) | 2020-01-14 |
| TWI786078B (zh) | 2022-12-11 |
| EP4311577A2 (fr) | 2024-01-31 |
| RU2019123854A3 (fr) | 2021-05-12 |
| MX2022012386A (es) | 2022-11-30 |
| DK3562487T3 (da) | 2024-01-02 |
| TW201831465A (zh) | 2018-09-01 |
| FI3562487T3 (fi) | 2023-12-14 |
| KR20190129034A (ko) | 2019-11-19 |
| EP3562487B1 (fr) | 2023-11-29 |
| US20190008861A1 (en) | 2019-01-10 |
| EP3562487A4 (fr) | 2020-08-26 |
| AU2017387033A1 (en) | 2019-08-15 |
| WO2018125800A2 (fr) | 2018-07-05 |
| US20180185362A1 (en) | 2018-07-05 |
| ES2967119T3 (es) | 2024-04-26 |
| US11040034B2 (en) | 2021-06-22 |
| CA3055292A1 (fr) | 2018-07-05 |
| JP2023071692A (ja) | 2023-05-23 |
| AU2024202860A1 (en) | 2024-05-23 |
| RU2019123854A (ru) | 2021-02-01 |
| WO2018125800A3 (fr) | 2018-08-16 |
| US10085984B2 (en) | 2018-10-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2018008105A (es) | Compuestos inhibidores de metaloenzima. | |
| WO2011133875A3 (fr) | Composés inhibiteurs de métalloenzyme | |
| WO2012177603A3 (fr) | Composés inhibiteurs de métalloenzymes | |
| EP4311577A3 (fr) | Composés inhibiteurs de métalloenzymes | |
| MX2013015158A (es) | Compuestos inhibidores de metaloenzima. | |
| CY1120246T1 (el) | Ενωσεις αναστολεων μεταλλοενζυμου | |
| IN2014DN00286A (fr) | ||
| GEP20247593B (en) | Compositions and methods of inhibiting masp-3 for the treatment of various diseases and disorders | |
| WO2012064943A3 (fr) | Composés inhibiteurs de métalloenzymes | |
| IN2014DN06792A (fr) | ||
| EA201690007A1 (ru) | Соединения, ингибирующие металлоферменты | |
| WO2016172658A3 (fr) | Régulateurs du microbiome et leurs utilisations associées | |
| PH12016501600A1 (en) | 2-amino-3, 5, 5-trifluoro-3, 4, 5, 6-tetrahydropyridines as bace1 inhibitors for treatment of alzheimer's disease | |
| MX2022007436A (es) | Inhibidores de la autotaxina y sus usos. | |
| MX2020005567A (es) | Metodos de tratamiento con asparaginasa. | |
| WO2011082245A3 (fr) | Composés inhibiteurs de métallo-enzyme | |
| EA201591278A1 (ru) | Композиции, содержащие c1-inh, и способы профилактики и лечения расстройств, ассоциированых с дефицитом ингибитора с1 эстеразы | |
| UY36080A (es) | Compuestos inhibidores de metaloenzima como fungicidas. | |
| WO2015200790A3 (fr) | Compositions et procédés pour réguler la rénalase dans le traitement de certaines maladies et de certains troubles | |
| WO2017139697A8 (fr) | Bactéries modifiées en vue du traitement de maladies associées à l'hyperammoniémie | |
| PH12019500751A1 (en) | Carbamoyl phenylalaninol compounds and uses thereof | |
| WO2016200614A3 (fr) | Bactéries modifiées en vue du traitement de maladies associées à l'hyperammoniémie | |
| WO2012058529A3 (fr) | Composés inhibiteurs de métalloenzymes | |
| UY36081A (es) | Compuestos inhibidores de metaloenzima como fungicidas. | |
| WO2020021480A3 (fr) | Compositions et procédés de traitement de l'œil |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN PUBLISHED |
|
| AC | Divisional application: reference to earlier application |
Ref document number: 3562487 Country of ref document: EP Kind code of ref document: P |
|
| AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
| RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: HOEKSTRA, WILLIAM J. Inventor name: SHAVER, SAMMY Inventor name: YATES, CHRISTOPHER M. Inventor name: SPARKS, STEVEN |
|
| REG | Reference to a national code |
Ref country code: DE Ref legal event code: R079 Free format text: PREVIOUS MAIN CLASS: A61P0035000000 Ipc: C07D0403040000 |
|
| PUAL | Search report despatched |
Free format text: ORIGINAL CODE: 0009013 |
|
| AK | Designated contracting states |
Kind code of ref document: A3 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
| RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61P 35/00 20060101ALI20240311BHEP Ipc: A61P 3/00 20060101ALI20240311BHEP Ipc: A61P 1/00 20060101ALI20240311BHEP Ipc: A61K 31/501 20060101ALI20240311BHEP Ipc: A61K 31/437 20060101ALI20240311BHEP Ipc: C07D 417/14 20060101ALI20240311BHEP Ipc: C07D 471/04 20060101ALI20240311BHEP Ipc: C07D 405/14 20060101ALI20240311BHEP Ipc: C07D 401/14 20060101ALI20240311BHEP Ipc: C07D 403/14 20060101ALI20240311BHEP Ipc: C07D 403/04 20060101AFI20240311BHEP Ipc: A61P 9/00 20060101ALI20240311BHEP |
|
| RBV | Designated contracting states (corrected) |
Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |