EP4311577A3 - Composés inhibiteurs de métalloenzymes - Google Patents
Composés inhibiteurs de métalloenzymes Download PDFInfo
- Publication number
- EP4311577A3 EP4311577A3 EP23212447.9A EP23212447A EP4311577A3 EP 4311577 A3 EP4311577 A3 EP 4311577A3 EP 23212447 A EP23212447 A EP 23212447A EP 4311577 A3 EP4311577 A3 EP 4311577A3
- Authority
- EP
- European Patent Office
- Prior art keywords
- inhibitor compounds
- metalloenzyme inhibitor
- metalloenzyme
- compounds
- metalloenzymes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 229940125956 metalloenzyme inhibitor Drugs 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662440181P | 2016-12-29 | 2016-12-29 | |
| EP17887556.3A EP3562487B1 (fr) | 2016-12-29 | 2017-12-22 | Composés inhibiteurs des métalloenzymes |
| PCT/US2017/068190 WO2018125800A2 (fr) | 2016-12-29 | 2017-12-22 | Composés inhibiteurs des métalloenzymes |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP17887556.3A Division EP3562487B1 (fr) | 2016-12-29 | 2017-12-22 | Composés inhibiteurs des métalloenzymes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP4311577A2 EP4311577A2 (fr) | 2024-01-31 |
| EP4311577A3 true EP4311577A3 (fr) | 2024-04-17 |
Family
ID=62709109
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP17887556.3A Active EP3562487B1 (fr) | 2016-12-29 | 2017-12-22 | Composés inhibiteurs des métalloenzymes |
| EP23212447.9A Pending EP4311577A3 (fr) | 2016-12-29 | 2017-12-22 | Composés inhibiteurs de métalloenzymes |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP17887556.3A Active EP3562487B1 (fr) | 2016-12-29 | 2017-12-22 | Composés inhibiteurs des métalloenzymes |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10085984B2 (fr) |
| EP (2) | EP3562487B1 (fr) |
| JP (2) | JP7227157B2 (fr) |
| KR (1) | KR20190129034A (fr) |
| CN (1) | CN110691598A (fr) |
| AU (2) | AU2017387033B2 (fr) |
| BR (1) | BR112019013478A2 (fr) |
| CA (1) | CA3055292A1 (fr) |
| DK (1) | DK3562487T3 (fr) |
| ES (1) | ES2967119T3 (fr) |
| FI (1) | FI3562487T3 (fr) |
| MX (2) | MX2019007892A (fr) |
| RU (1) | RU2764666C2 (fr) |
| TW (1) | TWI786078B (fr) |
| WO (1) | WO2018125800A2 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2774267T3 (es) * | 2012-01-20 | 2020-07-20 | Mycovia Pharmaceuticals Inc | Compuestos inhibidores de metaloenzimas |
| EP3562306A4 (fr) | 2016-12-29 | 2020-06-24 | Selenity Therapeutics (Bermuda), Ltd. | Composés inhibiteurs des métalloenzymes |
| JP2022516969A (ja) * | 2019-01-08 | 2022-03-03 | フェーズバイオ ファーマシューティカルズ，インコーポレイテッド | 金属酵素阻害剤化合物 |
| GB201901757D0 (en) | 2019-02-08 | 2019-03-27 | Syngenta Crop Protection Ag | Herbicidal compounds |
| CN115803317A (zh) | 2020-05-19 | 2023-03-14 | 拜耳作物科学股份公司 | 作为杀真菌化合物的氮杂双环(硫代)酰胺 |
| BR112022024413A2 (pt) | 2020-06-10 | 2023-02-07 | Bayer Ag | Heterociclos substituídos com azabiciclila como fungicidas inovadores |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009156462A2 (fr) * | 2008-06-27 | 2009-12-30 | Novartis Ag | Composés organiques |
| WO2012012478A1 (fr) * | 2010-07-21 | 2012-01-26 | Merck Sharp & Dohme Corp. | Inhibiteurs de l'aldostérone synthase |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4921475A (en) | 1983-08-18 | 1990-05-01 | Drug Delivery Systems Inc. | Transdermal drug patch with microtubes |
| US5087240A (en) | 1983-08-18 | 1992-02-11 | Drug Delivery Systems Inc. | Transdermal drug patch with conductive fibers |
| US4738851A (en) | 1985-09-27 | 1988-04-19 | University Of Iowa Research Foundation, Inc. | Controlled release ophthalmic gel formulation |
| US5163899A (en) | 1987-03-20 | 1992-11-17 | Drug Delivery Systems Inc. | Transdermal drug delivery system |
| US5312325A (en) | 1987-05-28 | 1994-05-17 | Drug Delivery Systems Inc | Pulsating transdermal drug delivery system |
| GB8804164D0 (en) | 1988-02-23 | 1988-03-23 | Tucker J M | Bandage for administering physiologically active compound |
| US4882150A (en) | 1988-06-03 | 1989-11-21 | Kaufman Herbert E | Drug delivery system |
| US5008110A (en) | 1988-11-10 | 1991-04-16 | The Procter & Gamble Company | Storage-stable transdermal patch |
| US5088977A (en) | 1988-12-21 | 1992-02-18 | Drug Delivery Systems Inc. | Electrical transdermal drug applicator with counteractor and method of drug delivery |
| US5521222A (en) | 1989-09-28 | 1996-05-28 | Alcon Laboratories, Inc. | Topical ophthalmic pharmaceutical vehicles |
| ATE107176T1 (de) | 1989-12-04 | 1994-07-15 | Searle & Co | System zur transdermalen albuterol applikation. |
| US5106863A (en) | 1990-03-26 | 1992-04-21 | Ortho Pharmaceutical Corporation | Substituted imidazole and pyridine derivatives |
| US5077033A (en) | 1990-08-07 | 1991-12-31 | Mediventures Inc. | Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide |
| JP2594486B2 (ja) | 1991-01-15 | 1997-03-26 | アルコン ラボラトリーズ インコーポレイテッド | 局所的眼薬組成物 |
| US5352456A (en) | 1991-10-10 | 1994-10-04 | Cygnus Therapeutic Systems | Device for administering drug transdermally which provides an initial pulse of drug |
| JPH07502219A (ja) | 1991-12-18 | 1995-03-09 | ミネソタ マイニング アンド マニュファクチャリング カンパニー | 多重層型バリアー構造体 |
| EP0553769B1 (fr) | 1992-01-29 | 1996-01-03 | FRANZ VÖLKL GmbH & CO. SKI UND TENNIS SPORTARTIKELFABRIK KG | Raquette, en particulier raquette de tennis |
| IL114193A (en) | 1994-06-20 | 2000-02-29 | Teva Pharma | Ophthalmic pharmaceutical compositions based on sodium alginate |
| ES2094688B1 (es) | 1994-08-08 | 1997-08-01 | Cusi Lab | Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion. |
| IT1283911B1 (it) | 1996-02-05 | 1998-05-07 | Farmigea Spa | Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo |
| US5800807A (en) | 1997-01-29 | 1998-09-01 | Bausch & Lomb Incorporated | Ophthalmic compositions including glycerin and propylene glycol |
| US6261547B1 (en) | 1998-04-07 | 2001-07-17 | Alcon Manufacturing, Ltd. | Gelling ophthalmic compositions containing xanthan gum |
| US6197934B1 (en) | 1998-05-22 | 2001-03-06 | Collagenesis, Inc. | Compound delivery using rapidly dissolving collagen film |
| MXPA04003954A (es) | 2001-10-26 | 2004-11-29 | Aventis Pharma Inc | Bencimidazoles. |
| DE60305446T4 (de) * | 2002-01-07 | 2009-07-09 | Eisai R&D Management Co., Ltd. | Desazapurine und deren verwendung |
| EP1608628A2 (fr) | 2003-03-17 | 2005-12-28 | Takeda San Diego, Inc. | Inhibiteurs d'histone deacetylase |
| EP1604988A1 (fr) * | 2004-05-18 | 2005-12-14 | Sanofi-Aventis Deutschland GmbH | Dérivés de pyridazinone, méthodes de leur préparation et leur utilisation comme pharmaceutiques |
| PL1861387T3 (pl) | 2005-01-28 | 2014-08-29 | Dae Woong Pharma | Pochodne benzoimidazolu i ich kompozycje farmaceutyczne |
| AR055669A1 (es) * | 2005-10-03 | 2007-08-29 | Astrazeneca Ab | Derivados de 3h - imidazo[4, 5 -b]piridina como inhibidores selectivos de gsk3, metodos e internediarios para su preparacion, composiciones farmaceuticas que los contienen y su uso para la elaboracion de un medicamento para el tratamiento de enfermedades neurodegenerativas y mentales. |
| ES2274712B1 (es) | 2005-10-06 | 2008-03-01 | Laboratorios Almirall S.A. | Nuevos derivados imidazopiridina. |
| US20080027044A1 (en) | 2006-06-13 | 2008-01-31 | Kim Lewis | Prodrug antibiotic screens |
| EP1878724A1 (fr) | 2006-07-15 | 2008-01-16 | sanofi-aventis | Synthèse régiosélective des benzimidazoles et azabenzimidazoles catalysée par le palladium |
| WO2008128968A1 (fr) | 2007-04-19 | 2008-10-30 | Novartis Ag | Composés organiques |
| US7737175B2 (en) | 2007-06-01 | 2010-06-15 | Duke University | Methods and compositions for regulating HDAC4 activity |
| JP5492770B2 (ja) | 2007-06-26 | 2014-05-14 | サノフイ | ベンゾイミダゾール及びアザベンゾイミダゾールの位置選択的銅触媒合成 |
| US20100216796A1 (en) | 2007-10-04 | 2010-08-26 | Solomon Kattar | N-hydroxy-naphthalene dicarboxamide and n-hydroxy-biphenyl-dicarboxamide compounds as histone deacetylase inhibitors |
| JP2011511806A (ja) | 2008-02-07 | 2011-04-14 | マサチューセッツ・アイ・アンド・イア・インファーマリー | Ａｔｏｈ１発現を増強する化合物 |
| GB0821994D0 (en) | 2008-12-02 | 2009-01-07 | Ge Healthcare Ltd | In viva imaging method |
| JP5659224B2 (ja) | 2009-05-15 | 2015-01-28 | ノバルティス アーゲー | アルドステロンシンターゼ阻害剤としてのアリールピリジン |
| ES2663351T3 (es) | 2009-11-17 | 2018-04-12 | Novartis Ag | Derivados de aril-piridina como inhibidores de la aldosterona sintasa |
| AU2011311531B2 (en) | 2010-10-08 | 2014-11-20 | Life Sciences Research Partners Vzw | HDAC inhibitors to treat Charcot-Marie-Tooth disease |
| WO2012177852A1 (fr) | 2011-06-24 | 2012-12-27 | Arqule, Inc | Composés d'imidazopyridinyle substitués |
| WO2013033901A1 (fr) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Dérivés benzofuranes substitués par un hétérocycle et leurs procédés d'utilisation pour le traitement de maladies virales |
| CN103626783B (zh) * | 2012-08-22 | 2016-06-08 | 中国科学院上海药物研究所 | 双环稠杂环化合物及其用途和药物组合物 |
| US10022357B2 (en) | 2013-04-29 | 2018-07-17 | The General Hospital Corporation | Amyloid precursor protein MRNA blockers for treating Down syndrome and Alzheimer's disease |
| MY176401A (en) | 2014-04-24 | 2020-08-05 | Mitsubishi Tanabe Pharma Corp | Novel disubstituted 1,2,4-triazine compound |
| WO2015188369A1 (fr) | 2014-06-13 | 2015-12-17 | Merck Sharp & Dohme Corp. | Inhibiteurs puriques de la phosphatidylinositol 3-kinase delta humaine |
| WO2018118781A1 (fr) | 2016-12-20 | 2018-06-28 | Fmc Corporation | Oxadiazoles à activité fongicide |
| EP3562306A4 (fr) | 2016-12-29 | 2020-06-24 | Selenity Therapeutics (Bermuda), Ltd. | Composés inhibiteurs des métalloenzymes |
-
2017
- 2017-12-22 AU AU2017387033A patent/AU2017387033B2/en active Active
- 2017-12-22 EP EP17887556.3A patent/EP3562487B1/fr active Active
- 2017-12-22 FI FIEP17887556.3T patent/FI3562487T3/fi active
- 2017-12-22 RU RU2019123854A patent/RU2764666C2/ru active
- 2017-12-22 BR BR112019013478-6A patent/BR112019013478A2/pt active Search and Examination
- 2017-12-22 DK DK17887556.3T patent/DK3562487T3/da active
- 2017-12-22 ES ES17887556T patent/ES2967119T3/es active Active
- 2017-12-22 EP EP23212447.9A patent/EP4311577A3/fr active Pending
- 2017-12-22 WO PCT/US2017/068190 patent/WO2018125800A2/fr unknown
- 2017-12-22 MX MX2019007892A patent/MX2019007892A/es unknown
- 2017-12-22 JP JP2019556790A patent/JP7227157B2/ja active Active
- 2017-12-22 CN CN201780087610.1A patent/CN110691598A/zh active Pending
- 2017-12-22 CA CA3055292A patent/CA3055292A1/fr active Pending
- 2017-12-22 KR KR1020197022285A patent/KR20190129034A/ko active IP Right Grant
- 2017-12-29 US US15/857,950 patent/US10085984B2/en active Active
- 2017-12-29 TW TW106146533A patent/TWI786078B/zh active
-
2018
- 2018-09-07 US US16/124,846 patent/US11040034B2/en active Active
-
2019
- 2019-06-28 MX MX2022012386A patent/MX2022012386A/es unknown
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2021
- 2021-06-17 US US17/350,726 patent/US20210322409A1/en active Pending
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2023
- 2023-02-09 JP JP2023018482A patent/JP2023071692A/ja active Pending
-
2024
- 2024-05-01 AU AU2024202860A patent/AU2024202860A1/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009156462A2 (fr) * | 2008-06-27 | 2009-12-30 | Novartis Ag | Composés organiques |
| WO2012012478A1 (fr) * | 2010-07-21 | 2012-01-26 | Merck Sharp & Dohme Corp. | Inhibiteurs de l'aldostérone synthase |
Non-Patent Citations (4)
| Title |
|---|
| GÖKER, H. ET AL.: "Synthesis and potent antifungal activity against Candida species of some novel 1H-benzimidazoles", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 46, no. 5, 2009, pages 936 - 948, XP002596734, ISSN: 0022-152X, DOI: 10.1002/JHET.179 * |
| HOYT, S.B. ET AL.: "Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys", ACS MEDICINAL CHEMISTRY LETTERS, vol. 6, no. 5, 2015, pages 573 - 578, XP055534685, ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.5b00054 * |
| MEREDITH, E.L. ET AL.: "Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors", ACS MEDICINAL CHEMISTRY LETTERS, vol. 4, no. 12, 2013, pages 1203 - 1207, XP002755995, ISSN: 1948-5875, [retrieved on 20131017], DOI: 10.1021/ML400324C * |
| PAPILLON, J.P.N. ET AL.: "Discovery of N -[5-(6-Chloro-3-cyano-1-methyl-1 H -indol-2-yl)-pyridin-3-ylmethyl]-ethanesulfonamide, a Cortisol-Sparing CYP11B2 Inhibitor that Lowers Aldosterone in Human Subjects", JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, no. 23, 2015, pages 9382 - 9394, XP055715085, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.5b01545 * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2024202860A1 (en) | 2024-05-23 |
| WO2018125800A2 (fr) | 2018-07-05 |
| BR112019013478A2 (pt) | 2020-01-07 |
| TWI786078B (zh) | 2022-12-11 |
| RU2019123854A3 (fr) | 2021-05-12 |
| WO2018125800A3 (fr) | 2018-08-16 |
| KR20190129034A (ko) | 2019-11-19 |
| MX2019007892A (es) | 2020-02-05 |
| AU2017387033A1 (en) | 2019-08-15 |
| RU2019123854A (ru) | 2021-02-01 |
| US20210322409A1 (en) | 2021-10-21 |
| EP3562487A2 (fr) | 2019-11-06 |
| FI3562487T3 (fi) | 2023-12-14 |
| US11040034B2 (en) | 2021-06-22 |
| TW201831465A (zh) | 2018-09-01 |
| JP7227157B2 (ja) | 2023-02-21 |
| US20180185362A1 (en) | 2018-07-05 |
| JP2020510693A (ja) | 2020-04-09 |
| ES2967119T3 (es) | 2024-04-26 |
| CA3055292A1 (fr) | 2018-07-05 |
| EP4311577A2 (fr) | 2024-01-31 |
| MX2022012386A (es) | 2022-11-30 |
| EP3562487B1 (fr) | 2023-11-29 |
| JP2023071692A (ja) | 2023-05-23 |
| AU2017387033B2 (en) | 2024-02-01 |
| US20190008861A1 (en) | 2019-01-10 |
| RU2764666C2 (ru) | 2022-01-19 |
| US10085984B2 (en) | 2018-10-02 |
| DK3562487T3 (da) | 2024-01-02 |
| EP3562487A4 (fr) | 2020-08-26 |
| CN110691598A (zh) | 2020-01-14 |
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