EP4253603A1 - Oxydation électrochimique des cycloalcanes en composés de cycloalkanone - Google Patents
Oxydation électrochimique des cycloalcanes en composés de cycloalkanone Download PDFInfo
- Publication number
- EP4253603A1 EP4253603A1 EP22164767.0A EP22164767A EP4253603A1 EP 4253603 A1 EP4253603 A1 EP 4253603A1 EP 22164767 A EP22164767 A EP 22164767A EP 4253603 A1 EP4253603 A1 EP 4253603A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- group
- alkyl
- unsubstituted
- reaction medium
- branched
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000006056 electrooxidation reaction Methods 0.000 title claims abstract description 26
- 150000001924 cycloalkanes Chemical class 0.000 title description 9
- 150000001875 compounds Chemical class 0.000 title description 5
- 238000000034 method Methods 0.000 claims abstract description 124
- 239000012429 reaction media Substances 0.000 claims abstract description 75
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 70
- 230000008569 process Effects 0.000 claims abstract description 66
- 239000001301 oxygen Substances 0.000 claims abstract description 51
- 229930195733 hydrocarbon Natural products 0.000 claims abstract description 50
- 150000002430 hydrocarbons Chemical class 0.000 claims abstract description 49
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 44
- 229920006395 saturated elastomer Polymers 0.000 claims abstract description 39
- 150000002823 nitrates Chemical class 0.000 claims abstract description 31
- 238000005868 electrolysis reaction Methods 0.000 claims abstract description 30
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 103
- 239000007789 gas Substances 0.000 claims description 47
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 36
- 239000004215 Carbon black (E152) Substances 0.000 claims description 33
- -1 ammonium ions Chemical class 0.000 claims description 32
- 229910052799 carbon Inorganic materials 0.000 claims description 32
- 239000012298 atmosphere Substances 0.000 claims description 31
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 23
- 125000002950 monocyclic group Chemical group 0.000 claims description 20
- 229910002651 NO3 Inorganic materials 0.000 claims description 19
- NHNBFGGVMKEFGY-UHFFFAOYSA-N nitrate group Chemical group [N+](=O)([O-])[O-] NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims description 18
- 125000000217 alkyl group Chemical group 0.000 claims description 17
- WJTCGQSWYFHTAC-UHFFFAOYSA-N cyclooctane Chemical compound C1CCCCCCC1 WJTCGQSWYFHTAC-UHFFFAOYSA-N 0.000 claims description 17
- LRDFRRGEGBBSRN-UHFFFAOYSA-N isobutyronitrile Chemical compound CC(C)C#N LRDFRRGEGBBSRN-UHFFFAOYSA-N 0.000 claims description 17
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 16
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 16
- 229910052739 hydrogen Inorganic materials 0.000 claims description 16
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims description 15
- DDTBPAQBQHZRDW-UHFFFAOYSA-N cyclododecane Chemical compound C1CCCCCCCCCCC1 DDTBPAQBQHZRDW-UHFFFAOYSA-N 0.000 claims description 13
- 239000004914 cyclooctane Substances 0.000 claims description 13
- 238000003756 stirring Methods 0.000 claims description 13
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 12
- 150000001768 cations Chemical class 0.000 claims description 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 12
- BTGRAWJCKBQKAO-UHFFFAOYSA-N adiponitrile Chemical compound N#CCCCCC#N BTGRAWJCKBQKAO-UHFFFAOYSA-N 0.000 claims description 11
- 125000004432 carbon atom Chemical group C* 0.000 claims description 11
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 claims description 11
- 125000001424 substituent group Chemical group 0.000 claims description 11
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims description 10
- DMEGYFMYUHOHGS-UHFFFAOYSA-N cycloheptane Chemical compound C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 claims description 10
- IEJIGPNLZYLLBP-UHFFFAOYSA-N dimethyl carbonate Chemical compound COC(=O)OC IEJIGPNLZYLLBP-UHFFFAOYSA-N 0.000 claims description 10
- LMGZGXSXHCMSAA-UHFFFAOYSA-N cyclodecane Chemical compound C1CCCCCCCCC1 LMGZGXSXHCMSAA-UHFFFAOYSA-N 0.000 claims description 9
- 150000002576 ketones Chemical class 0.000 claims description 9
- FDPIMTJIUBPUKL-UHFFFAOYSA-N pentan-3-one Chemical compound CCC(=O)CC FDPIMTJIUBPUKL-UHFFFAOYSA-N 0.000 claims description 9
- GPTJTTCOVDDHER-UHFFFAOYSA-N cyclononane Chemical compound C1CCCCCCCC1 GPTJTTCOVDDHER-UHFFFAOYSA-N 0.000 claims description 8
- KYTNZWVKKKJXFS-UHFFFAOYSA-N cycloundecane Chemical compound C1CCCCCCCCCC1 KYTNZWVKKKJXFS-UHFFFAOYSA-N 0.000 claims description 8
- YEJRWHAVMIAJKC-UHFFFAOYSA-N 4-Butyrolactone Chemical compound O=C1CCCO1 YEJRWHAVMIAJKC-UHFFFAOYSA-N 0.000 claims description 7
- JSZOAYXJRCEYSX-UHFFFAOYSA-N 1-nitropropane Chemical compound CCC[N+]([O-])=O JSZOAYXJRCEYSX-UHFFFAOYSA-N 0.000 claims description 6
- 125000002619 bicyclic group Chemical group 0.000 claims description 6
- 125000003367 polycyclic group Chemical group 0.000 claims description 6
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims description 5
- 229930195734 saturated hydrocarbon Natural products 0.000 claims description 5
- 125000004122 cyclic group Chemical group 0.000 claims description 4
- LYGJENNIWJXYER-UHFFFAOYSA-N nitromethane Chemical compound C[N+]([O-])=O LYGJENNIWJXYER-UHFFFAOYSA-N 0.000 claims description 4
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 claims description 3
- 150000005676 cyclic carbonates Chemical class 0.000 claims description 3
- 150000002148 esters Chemical class 0.000 claims description 3
- 150000002170 ethers Chemical class 0.000 claims description 3
- 150000002596 lactones Chemical class 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims 1
- 239000000047 product Substances 0.000 description 27
- 238000006243 chemical reaction Methods 0.000 description 26
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 24
- 239000002904 solvent Substances 0.000 description 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 21
- MSXVEPNJUHWQHW-UHFFFAOYSA-N 2-methylbutan-2-ol Chemical compound CCC(C)(C)O MSXVEPNJUHWQHW-UHFFFAOYSA-N 0.000 description 18
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 18
- 150000003839 salts Chemical class 0.000 description 18
- 238000005160 1H NMR spectroscopy Methods 0.000 description 16
- FHADSMKORVFYOS-UHFFFAOYSA-N cyclooctanol Chemical compound OC1CCCCCCC1 FHADSMKORVFYOS-UHFFFAOYSA-N 0.000 description 15
- 238000004821 distillation Methods 0.000 description 14
- 229910021397 glassy carbon Inorganic materials 0.000 description 14
- 230000003647 oxidation Effects 0.000 description 14
- 238000007254 oxidation reaction Methods 0.000 description 14
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 12
- IIRFCWANHMSDCG-UHFFFAOYSA-N cyclooctanone Chemical compound O=C1CCCCCCC1 IIRFCWANHMSDCG-UHFFFAOYSA-N 0.000 description 12
- 238000011835 investigation Methods 0.000 description 12
- 239000000203 mixture Substances 0.000 description 10
- 230000003381 solubilizing effect Effects 0.000 description 10
- 239000000126 substance Substances 0.000 description 10
- 239000000758 substrate Substances 0.000 description 10
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 9
- 238000006467 substitution reaction Methods 0.000 description 9
- 241001655883 Adeno-associated virus - 1 Species 0.000 description 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 8
- 230000015572 biosynthetic process Effects 0.000 description 8
- 239000007772 electrode material Substances 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 7
- 239000003570 air Substances 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- LKUDPHPHKOZXCD-UHFFFAOYSA-N 1,3,5-trimethoxybenzene Chemical compound COC1=CC(OC)=CC(OC)=C1 LKUDPHPHKOZXCD-UHFFFAOYSA-N 0.000 description 6
- SXVPOSFURRDKBO-UHFFFAOYSA-N Cyclododecanone Chemical compound O=C1CCCCCCCCCCC1 SXVPOSFURRDKBO-UHFFFAOYSA-N 0.000 description 6
- 229960001760 dimethyl sulfoxide Drugs 0.000 description 6
- 229910002804 graphite Inorganic materials 0.000 description 6
- 239000010439 graphite Substances 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 239000007800 oxidant agent Substances 0.000 description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 5
- 150000001298 alcohols Chemical class 0.000 description 5
- 238000004587 chromatography analysis Methods 0.000 description 5
- 238000007654 immersion Methods 0.000 description 5
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 5
- 238000011002 quantification Methods 0.000 description 5
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
- 238000005481 NMR spectroscopy Methods 0.000 description 4
- 239000003054 catalyst Substances 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- UEPYVEILIFKOAA-UHFFFAOYSA-N methyl(trioctyl)azanium;nitrate Chemical compound [O-][N+]([O-])=O.CCCCCCCC[N+](C)(CCCCCCCC)CCCCCCCC UEPYVEILIFKOAA-UHFFFAOYSA-N 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 150000002978 peroxides Chemical class 0.000 description 4
- 150000003254 radicals Chemical class 0.000 description 4
- LLNAMUJRIZIXHF-CLFYSBASSA-N (z)-2-methyl-3-phenylprop-2-en-1-ol Chemical compound OCC(/C)=C\C1=CC=CC=C1 LLNAMUJRIZIXHF-CLFYSBASSA-N 0.000 description 3
- WPHIMOZSRUCGGU-UHFFFAOYSA-N 1-butyl-3-methylimidazol-3-ium;nitrate Chemical group [O-][N+]([O-])=O.CCCCN1C=C[N+](C)=C1 WPHIMOZSRUCGGU-UHFFFAOYSA-N 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 239000004809 Teflon Substances 0.000 description 3
- 229920006362 Teflon® Polymers 0.000 description 3
- 125000001931 aliphatic group Chemical group 0.000 description 3
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- 239000006227 byproduct Substances 0.000 description 3
- 238000004440 column chromatography Methods 0.000 description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 238000000769 gas chromatography-flame ionisation detection Methods 0.000 description 3
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 description 3
- NPENQLDGJBRHHE-UHFFFAOYSA-N methyl(trioctyl)phosphanium;nitrate Chemical compound [O-][N+]([O-])=O.CCCCCCCC[P+](C)(CCCCCCCC)CCCCCCCC NPENQLDGJBRHHE-UHFFFAOYSA-N 0.000 description 3
- 239000000741 silica gel Substances 0.000 description 3
- 229910002027 silica gel Inorganic materials 0.000 description 3
- 229910001220 stainless steel Inorganic materials 0.000 description 3
- 239000010935 stainless steel Substances 0.000 description 3
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- 239000002028 Biomass Substances 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- ORILYTVJVMAKLC-UHFFFAOYSA-N adamantane Chemical compound C1C(C2)CC3CC1CC2C3 ORILYTVJVMAKLC-UHFFFAOYSA-N 0.000 description 2
- 150000001335 aliphatic alkanes Chemical class 0.000 description 2
- DVARTQFDIMZBAA-UHFFFAOYSA-O ammonium nitrate Chemical compound [NH4+].[O-][N+]([O-])=O DVARTQFDIMZBAA-UHFFFAOYSA-O 0.000 description 2
- 150000001450 anions Chemical class 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 229910052810 boron oxide Inorganic materials 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- JKWMSGQKBLHBQQ-UHFFFAOYSA-N diboron trioxide Chemical compound O=BOB=O JKWMSGQKBLHBQQ-UHFFFAOYSA-N 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000008151 electrolyte solution Substances 0.000 description 2
- 229940021013 electrolyte solution Drugs 0.000 description 2
- 239000003480 eluent Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 2
- 235000019341 magnesium sulphate Nutrition 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 239000012074 organic phase Substances 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 238000005191 phase separation Methods 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 description 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 2
- 150000003138 primary alcohols Chemical class 0.000 description 2
- 150000003333 secondary alcohols Chemical class 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 description 2
- 229910052938 sodium sulfate Inorganic materials 0.000 description 2
- 235000011152 sodium sulphate Nutrition 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- DZLFLBLQUQXARW-UHFFFAOYSA-N tetrabutylammonium Chemical compound CCCC[N+](CCCC)(CCCC)CCCC DZLFLBLQUQXARW-UHFFFAOYSA-N 0.000 description 2
- QHOKENWFMZXSEU-UHFFFAOYSA-N tetrabutylazanium;nitrate Chemical compound [O-][N+]([O-])=O.CCCC[N+](CCCC)(CCCC)CCCC QHOKENWFMZXSEU-UHFFFAOYSA-N 0.000 description 2
- BJQWBACJIAKDTJ-UHFFFAOYSA-N tetrabutylphosphanium Chemical compound CCCC[P+](CCCC)(CCCC)CCCC BJQWBACJIAKDTJ-UHFFFAOYSA-N 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 229910052723 transition metal Inorganic materials 0.000 description 2
- 150000003624 transition metals Chemical class 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 238000010626 work up procedure Methods 0.000 description 2
- BYEAHWXPCBROCE-UHFFFAOYSA-N 1,1,1,3,3,3-hexafluoropropan-2-ol Chemical compound FC(F)(F)C(O)C(F)(F)F BYEAHWXPCBROCE-UHFFFAOYSA-N 0.000 description 1
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- CXBDYQVECUFKRK-UHFFFAOYSA-N 1-methoxybutane Chemical compound CCCCOC CXBDYQVECUFKRK-UHFFFAOYSA-N 0.000 description 1
- XSROMLOMDFTVMJ-UHFFFAOYSA-O 1h-imidazol-1-ium;nitrate Chemical compound [O-][N+]([O-])=O.[NH2+]1C=CN=C1 XSROMLOMDFTVMJ-UHFFFAOYSA-O 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- 241000202702 Adeno-associated virus - 3 Species 0.000 description 1
- 101100361281 Caenorhabditis elegans rpm-1 gene Proteins 0.000 description 1
- 229920000049 Carbon (fiber) Polymers 0.000 description 1
- JHWNWJKBPDFINM-UHFFFAOYSA-N Laurolactam Chemical compound O=C1CCCCCCCCCCCN1 JHWNWJKBPDFINM-UHFFFAOYSA-N 0.000 description 1
- 229920000299 Nylon 12 Polymers 0.000 description 1
- 240000007817 Olea europaea Species 0.000 description 1
- IXNSXHYINKZAHI-UHFFFAOYSA-O [N+](=O)([O-])[O-].[NH4+].C(CCC)[N+](CCCC)(CCCC)CCCC.[N+](=O)([O-])[O-] Chemical compound [N+](=O)([O-])[O-].[NH4+].C(CCC)[N+](CCCC)(CCCC)CCCC.[N+](=O)([O-])[O-] IXNSXHYINKZAHI-UHFFFAOYSA-O 0.000 description 1
- CUJRVFIICFDLGR-UHFFFAOYSA-N acetylacetonate Chemical compound CC(=O)[CH-]C(C)=O CUJRVFIICFDLGR-UHFFFAOYSA-N 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 150000001721 carbon Chemical group 0.000 description 1
- 239000004917 carbon fiber Substances 0.000 description 1
- 238000001460 carbon-13 nuclear magnetic resonance spectrum Methods 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- PBAYDYUZOSNJGU-UHFFFAOYSA-N chelidonic acid Natural products OC(=O)C1=CC(=O)C=C(C(O)=O)O1 PBAYDYUZOSNJGU-UHFFFAOYSA-N 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- SXOZDDAFVJANJP-UHFFFAOYSA-N cyclodecanone Chemical compound O=C1CCCCCCCCC1 SXOZDDAFVJANJP-UHFFFAOYSA-N 0.000 description 1
- CGZZMOTZOONQIA-UHFFFAOYSA-N cycloheptanone Chemical compound O=C1CCCCCC1 CGZZMOTZOONQIA-UHFFFAOYSA-N 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 238000007306 functionalization reaction Methods 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- RJQRSXSVTJIKOH-UHFFFAOYSA-N hexadecyl(trimethyl)azanium;nitrate Chemical compound [O-][N+]([O-])=O.CCCCCCCCCCCCCCCC[N+](C)(C)C RJQRSXSVTJIKOH-UHFFFAOYSA-N 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000000589 high-performance liquid chromatography-mass spectrometry Methods 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 229910001959 inorganic nitrate Inorganic materials 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 238000003760 magnetic stirring Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- QLPMKRZYJPNIRP-UHFFFAOYSA-M methyl(trioctyl)azanium;bromide Chemical compound [Br-].CCCCCCCC[N+](C)(CCCCCCCC)CCCCCCCC QLPMKRZYJPNIRP-UHFFFAOYSA-M 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 239000012457 nonaqueous media Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- MTKLVWMDKKAGQI-UHFFFAOYSA-O phosphanium;nitrate Chemical compound [PH4+].[O-][N+]([O-])=O MTKLVWMDKKAGQI-UHFFFAOYSA-O 0.000 description 1
- 150000004714 phosphonium salts Chemical class 0.000 description 1
- 239000004323 potassium nitrate Substances 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 1
- SBYHFKPVCBCYGV-UHFFFAOYSA-N quinuclidine Chemical compound C1CC2CCN1CC2 SBYHFKPVCBCYGV-UHFFFAOYSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 239000004317 sodium nitrate Substances 0.000 description 1
- 235000010344 sodium nitrate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 231100000378 teratogenic Toxicity 0.000 description 1
- 230000003390 teratogenic effect Effects 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- KUBXSUKJFAQDPV-UHFFFAOYSA-N tetrabutylphosphanium;nitrate Chemical compound [O-][N+]([O-])=O.CCCC[P+](CCCC)(CCCC)CCCC KUBXSUKJFAQDPV-UHFFFAOYSA-N 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
- C25B3/00—Electrolytic production of organic compounds
- C25B3/01—Products
- C25B3/07—Oxygen containing compounds
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
- C25B3/00—Electrolytic production of organic compounds
- C25B3/20—Processes
- C25B3/23—Oxidation
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
- C25B9/00—Cells or assemblies of cells; Constructional parts of cells; Assemblies of constructional parts, e.g. electrode-diaphragm assemblies; Process-related cell features
- C25B9/13—Single electrolytic cells with circulation of an electrolyte
- C25B9/15—Flow-through cells
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
- C25B9/00—Cells or assemblies of cells; Constructional parts of cells; Assemblies of constructional parts, e.g. electrode-diaphragm assemblies; Process-related cell features
- C25B9/17—Cells comprising dimensionally-stable non-movable electrodes; Assemblies of constructional parts thereof
Definitions
- the invention relates to a process for producing unsubstituted or at least monosubstituted cycloalkanones by electrochemical oxidation of unsubstituted or at least monosubstituted saturated cycloaliphatic hydrocarbons by electrochemical oxidation in the presence of an inorganic or organic nitrate salt in an electrolysis cell in a reaction medium in the presence of oxygen.
- Cycloalkanone and cycloalkanol compounds are important intermediates in a variety of industrial manufacturing processes.
- the oxidation of saturated, non-functionalized cycloaliphatic hydrocarbons (and thus non-activated C-H bonds) to corresponding ketones or alcohols requires special reaction conditions in order to selectively convert these inert substances into monofunctional secondary products to be transferred while preserving the ring framework.
- the process according to the invention is characterized in particular by high selectivity, small amounts of auxiliary chemicals used, the use of electric current as an oxidizing agent and, associated with this, by a reduced amount of waste products.
- atmospheric oxygen can be used to introduce the oxygen function into cycloaliphatic hydrocarbons.
- chemical oxidizing agents such as reactive peroxides, and high-priced catalysts with complex ligand systems can be dispensed with.
- toxic and/or potentially carcinogenic reagents can be reduced or even completely avoided.
- the method developed represents a cost-effective and environmentally friendly alternative to existing syntheses. Due to the simple and safe process conditions, large quantities of the desired compounds can be produced without great effort. Through the present invention, previously cost- and time-intensive processes can be significantly optimized.
- the process according to the invention enables the use of electric current to produce cycloalkanone compounds from unsubstituted cycloalkanes using nitrate salts, which function both as a conductive salt and as an electrochemical mediator. If by-products arise when carrying out the process according to the invention, in particular cycloaliphatic alcohols of the same ring size, this is not a problem because they can be converted into the corresponding ketones by already established subsequent processes.
- the method according to the invention can be carried out under ambient pressure and ambient temperature, which also has an advantageous effect on energy efficiency and thus also environmental compatibility.
- Unsubstituted or at least monosubstituted, saturated cycloaliphatic hydrocarbons that are monocyclic or polycyclic can be used in the process according to the invention.
- Monocyclic or bicyclic cycloaliphatic hydrocarbons are preferred.
- Monocyclic cycloaliphatic hydrocarbons are particularly preferably used in the process according to the invention.
- the monocyclic or polycyclic, in particular monocyclic or bicyclic, saturated cycloaliphatic hydrocarbons used in the process according to the invention can preferably have 5 to 18 C atoms in the ring system.
- These cycloaliphatic hydrocarbons can each be unsubstituted or mono- or poly-substituted. If they are substituted once or multiple times, they are preferably substituted with 1, 2, 3, 4 or 5 substituents, independently of one another, each selected from the group consisting of methyl, phenyl or benzyl.
- phenyl or benzyl substituents themselves can each be unsubstituted or mono- or polysubstituted, with 1, 2 or 3 substituents, independently of one another, each selected from the group consisting of F, Cl, Br, and NO 2 . If the cycloaliphatic hydrocarbons used according to the invention or their substituents have alkyl radicals with more than one carbon atom in the side chain, undesirable side reactions occur at these substituents when carrying out the process according to the invention.
- Particularly preferred in the process according to the invention are monocyclic saturated hydrocarbons with 6 to 12 carbon atoms in the ring, preferably with 8 to 12 carbon atoms in the ring, which are unsubstituted or substituted once or multiple times with 1 as unsubstituted or at least monosubstituted, saturated cycloaliphatic hydrocarbons , 2, 3, 4 or 5 substituents, independently of one another, each selected from the group consisting of methyl, phenyl or benzyl.
- monocyclic saturated hydrocarbons with 8 to 12 carbon atoms in the ring in the process according to the invention, which are unsubstituted or mono- or di- or tri-substituted with a methyl group.
- the saturated monocyclic hydrocarbon is unsubstituted and is selected from the group consisting of cyclohexane, cycloheptane, cyclooctane, cyclononane, cyclodecane, cycloundecane and cyclododecane, even more preferably selected from the group consisting of cyclooctane, cyclononane, cyclodecane, cycloundecane and cyclododecane, most preferred is the hydrocarbon cyclododecane.
- step (b) of the process according to the invention at least one inorganic or organic nitrate salt is provided.
- This nitrate salt acts both as a conductive salt and as a mediator in the electrochemical oxidation process according to the invention.
- An inorganic or organic nitrate of the general formula is preferred [Cation + ][NO 3 - ] for use, whereby the [cation + ] is selected from the group consisting of Na + , K + , ammonium ions with the general structure [R 1 R 2 R 3 R 4 N + ] with R 1 , R 2 , R 3 , R 4 , independently of one another, each selected from the group consisting of C 1 - to C 16 -alkyl, in particular C 1 - to C 8 -alkyl, straight-chain or branched, imidazolium cations with the general structure (I) with R 1 and R 2 , independently of one another, each selected from the group consisting of C 1 - to C 18 alkyl
- Phosphonium ions with the general structure [R 1a R 2a R 3a R 4a P + ] with R 1a , R 2a , R 3a , R 4a , independently of one another, each selected from the group consisting of C 1 - to C 16 alkyl, in particular C 1 - to C 8 alkyl, straight chain or branched.
- R 1 is C 1 - to C 18 -alkyl, straight-chain or branched, in particular C 1 - to C 8 -alkyl, straight-chain or branched
- R 2 , R 3 and R 4 independently of one another, are each selected from the group consisting of C 1 - to C 8 alkyl, straight-chain or branched, where a single substitution in the 2-, 3- or 4-position, a double substitution in 2,4-, 2,5- or 2,6-position or a triple substitution in 2,4,6-position is preferred.
- nitrate salt according to the invention is preferably used, in particular an organic ammonium nitrate salt of the composition [R 1 R 2 R 3 R 4 N + ][NO 3 - ] or an organic one Phosphonium salt of the composition [R 1a R 2a R 3a R 4a P + ][NO 3 - ], with an organic ammonium nitrate salt of the composition [R 1 R 2 R 3 R 4 N + ][NO 3 - ] being particularly preferred.
- the organic ammonium nitrate salt tetra-n-butyl ammonium nitrate or methyl tri-n-octylammonium nitrate is very particularly preferred.
- the organic phosphonium nitrate salt is most preferably tetra-n-butylphosphonium nitrate or methyltri-n-octylphosphonium nitrate.
- the organic imidazolium nitrate salt is preferably 1-butyl-3-methylimidazolium nitrate.
- Tetra-n-butyl ammonium nitrate or methyl tri-n-octylammonium nitrate is most preferably used as the organic nitrate salt in the process according to the invention.
- the unsubstituted or at least monosubstituted, saturated cycloaliphatic hydrocarbon or the inorganic or organic nitrate salt is introduced and brought together with the reaction medium, preferably at least partially or completely dissolved in the reaction medium or mixed with it, and then the other of these added to both components.
- the unsubstituted or at least monosubstituted, saturated cycloaliphatic hydrocarbon and the inorganic or organic nitrate salt are introduced and then brought together with the reaction medium, preferably at least partially or completely dissolved in the reaction medium or mixed with it.
- the unsubstituted or at least monosubstituted, saturated cycloaliphatic hydrocarbon and the inorganic or organic nitrate salt are added to the reaction medium simultaneously or in succession to one another, preferably at least partially or completely dissolved in the reaction medium or with it be mixed.
- the reaction medium used in the process according to the invention is liquid under the conditions under which the process is carried out and is suitable for partially or completely dissolving the components used, i.e. in particular the unsubstituted or at least monosubstituted, saturated cycloaliphatic hydrocarbon and the inorganic or organic nitrate salt. If at least one of these components is used in liquid form, the reaction medium is preferably easily miscible with this component or these components.
- a polar aprotic reaction medium is preferably used in the process according to the invention for electrochemical oxidation. This can be used in anhydrous form, in dried form or in combination with water.
- the reaction medium advantageously contains water, with aprotic reaction medium in combination with water being preferred.
- the water content in the reaction medium can vary.
- the water content is preferably up to 20% by volume, particularly preferably up to 15% by volume, very particularly preferably up to 10% by volume, even more preferably up to 5% by volume, in each case on the total amount of reaction medium.
- the polar aprotic reaction medium is preferably selected from the group consisting of aliphatic nitriles, aliphatic ketones, cycloaliphatic ketones, dialkyl carbonates, cyclic carbonates, lactones, aliphatic nitroalkanes, and dimethyl sulfoxide, esters and ethers or a combination of at least two of these components.
- the reaction medium is particularly preferably selected from the group consisting of acetonitrile, isobutyronitrile, adiponitrile, acetone, dimethyl carbonate, methyl ethyl ketone, 3-pentanone, cyclohexanone, nitromethane, nitropropane, tert-butyl methyl ether, dimethyl sulfoxide, gamma-butyrolactone and epsilon-caprolactone or a combination from at least two of these components.
- the reaction medium is selected from the group consisting of acetonitrile, isobutyronitrile, adiponitrile, dimethyl carbonate and acetone or a combination of at least two of these components.
- the reaction medium is very particularly preferably acetonitrile, isobutyronitrile or adiponitrile in dried or anhydrous form.
- the reaction medium is also very particularly preferred: acetonitrile, isobutyronitrile or adiponitrile, optionally in combination with water.
- the water content is preferably up to 20% by volume, particularly preferably up to 15% by volume, very particularly preferably up to 10% by volume. %, even more preferably up to 5% by volume, based on the total amount of reaction medium.
- solubilizing components it may be advantageous to add further solubilizing components to the reaction medium.
- Suitable advantageous components can be determined through simple preliminary tests on solution behavior.
- Suitable solubilizing components include, for example, primary alcohols, secondary alcohols, monoketones or dialkyl carbonates or mixtures of at least two of these components, possibly in combination with water.
- Aliphatic C 1-6 alcohols can preferably be used in the process according to the invention, with particularly preferred solubilizing components being selected from the group consisting of methanol, ethanol, isopropanol, 2-methyl-2-butanol or mixtures of at least two of these components , if necessary in combination with water.
- dimethyl carbonate as a reaction medium can be particularly advantageous, if necessary in combination with at least one C 1-6 alcohol, in particular selected from the group consisting of methanol, ethanol, isopropanol, 2-methyl-2-butanol, if necessary in combination with be water.
- the water content is preferably up to 20% by volume, particularly preferably up to 15% by volume, very particularly preferably up to 10% by volume, even further preferably up to 5% by volume, based on the total amount of solubilizing component and water.
- the solubilizing components can preferably be added in amounts of ⁇ 50% by volume, particularly preferably ⁇ 30% by volume and very particularly preferably ⁇ 10% by volume, in each case based on the total amount of reaction medium.
- the inorganic or organic nitrate salt is used in the process according to the invention in an amount of 0.1 to 2.0, preferably 0.2 to 1.0, particularly preferably 0.3 to 0.8 and very particularly preferably 0.4 to 0.8 Equivalents, each based on the amount of unsubstituted or at least monosubstituted, saturated cycloaliphatic hydrocarbon used.
- the electrochemical oxidation of the unsubstituted or at least monosubstituted saturated cycloaliphatic hydrocarbon takes place in the presence of the inorganic or organic nitrate salt in an electrolysis cell in a reaction medium in the presence of oxygen.
- a gas atmosphere containing oxygen is advantageously provided in spatial connection with the reaction medium.
- the proportion of oxygen in the gas atmosphere can vary.
- the proportion of oxygen in the gas atmosphere is preferably 10 to 100% by volume, particularly preferably 15 to 30% by volume, particularly preferably 15 to 25% by volume, very particularly preferably 18 to 22% by volume.
- the proportion of oxygen in the gas atmosphere can be 10 to 100% by volume, particularly preferably 15 to 100% by volume, particularly preferably 20 to 100% by volume.
- the gas atmosphere is particularly preferably air.
- a gas exchange is advantageously forced between the gas atmosphere and the reaction medium, preferably by introducing a gas atmosphere into the reaction medium or by stirring the liquid phase in the presence of the gas atmosphere.
- the gas exchange between the gas atmosphere and the reaction medium in particular stirring, for example via the geometry of the stirrer or the stirring speed, can be used to control the electrochemical oxidation.
- the amount of oxygen dissolved in the reaction medium is preferably at least 1 mmol/L reaction medium, particularly preferably at least 5 mmol/L reaction medium.
- the amount of oxygen dissolved in the reaction medium is also preferably at least 10 mmol/L reaction medium.
- the process according to the invention for producing unsubstituted or at least monosubstituted cycloalkanones by electrochemical oxidation of unsubstituted or at least monosubstituted saturated cycloaliphatic hydrocarbons by electrochemical oxidation in the presence of an inorganic or organic nitrate salt in a reaction medium in the presence of oxygen can be carried out in both a divided and carry out in an undivided electrolysis cell, with implementation in an undivided electrolysis cell being preferred.
- the undivided electrolysis cell which is preferably used according to the invention has at least two electrodes.
- Anodes and cathodes of common materials can be used here, for example glassy carbon, boron-doped diamond (BDD) or graphite. The use of glassy carbon electrodes is preferred.
- the undivided electrolysis cell preferably has at least one glassy carbon anode or at least one glassy carbon cathode. Both the anode and the cathode are preferably glassy carbon electrodes.
- the distance between the electrodes can vary over a certain range.
- the distance is preferably 0.1 mm to 2.0 cm, particularly preferably 0.1 mm to 1.0 cm, particularly preferably 0.1 mm to 0.5 cm.
- process according to the invention can be carried out batchwise or continuously, preferably in an undivided flow-through electrolysis cell.
- the process according to the invention is preferably carried out with a charge amount of 190 C (2 F) to 970 C (10 F), particularly preferably 320 C to 820 C, very particularly preferably 350 C to 800 C, even more preferably 380 C to 775 C most preferably 380 C to 450 C, in each case based on 1 mmol of unsubstituted or at least monosubstituted saturated cycloaliphatic hydrocarbon.
- the electrochemical oxidation in the process according to the invention preferably takes place at constant current intensity.
- the current density at which the method according to the invention is carried out is preferably at least 5 mA/cm 2 or at least 10 mA/cm 2 or at least 15 mA/cm 2 or at least 20 mA/cm 2 or 20 mA/cm 2 to 50 mA/ cm 2 , whereby the area refers to the geometric area of the electrodes.
- a significant advantage of the method according to the invention is that electric current is used as the oxidizing agent, which is a particularly environmentally friendly agent when it comes from renewable sources, i.e. in particular from biomass, solar thermal energy, geothermal energy, hydropower, wind power or photovoltaics.
- the process according to the invention can be carried out over a wide temperature range, for example at a temperature in the range from 0 to 60°C, preferably from 5 to 50°C, particularly preferably 10 to 40°C, very particularly preferably 15 to 30°C.
- the process according to the invention can be carried out at increased or reduced pressure. If the process according to the invention is carried out at elevated pressure, a pressure of up to 16 bar is preferred, particularly preferably up to 6 bar.
- the process according to the invention can also preferably be carried out under atmospheric pressure.
- the products produced by the process according to the invention can be isolated or purified by conventional processes known to those skilled in the art, in particular by extraction, crystallization, centrifugation, precipitation, distillation, evaporation or chromatography.
- Analytical grade chemicals were purchased and used from mainstream suppliers (such as TCI, Aldrich, and Acros).
- the oxygen was purchased in 2.5 quality from NIPPON GASES GmbH, Düsseldorf, Germany and used directly.
- NMR spectrometry of 1H-NMR and 13C-NMR spectra were recorded at 25 °C with a Bruker Avance II 400 (400 MHz, 5 mm BBFO head with z-gradient and ATM, SampleXPress 60 sample changer, Analytician Messtechnik, Düsseldorf, Germany) recorded.
- the gas introduction was controlled via two mass flow controllers (MFC) model 5850S from Brooks Instrument BV, Veenendaal, Netherlands.
- MFC mass flow controller
- a regulator was used for the oxygen and nitrogen lines.
- the controllers were controlled using the Smart DDE and Matlab R2017b software.
- the volume flow control was also carried out using a DK800 variable area flowmeter from KROHNE Messtechnik GmbH, Duisburg.
- the total volume flow was a constant 20 mL/min, which, limited by the MFCs used, also represents the maximum achievable volume flow.
- the percentage volume flows of the two gases were set using the MFCs and their software.
- the gas bottles were used from the following suppliers: Oxygen 2.5 from NIPPON GASES GmbH, Düsseldorf, and nitrogen 4.8 from Nonetheless AG, Weg and nitrogen 5.0 from NIPPON GASES GmbH, Düsseldorf.
- the apparatus was equipped with a gas distributor including an adapter and a Teflon cover for the electrolysis cells.
- the cycloalkane (5.0 mmol) and tetrabutylammonium nitrate (0.5 eq.) were placed in an undivided electrolysis cell (100 mL three-neck round bottom flask, NS29 Teflon stopper with electrode holders, magnetic stirring rod) and dissolved in acetonitrile (25 mL).
- the cell was equipped with glassy carbon electrodes (3 cm ⁇ 1 cm ⁇ 0.3 cm), spaced 0.5 cm apart.
- the immersion area of the electrodes was 1.3 cm 2 . If necessary, oxygen was introduced into the gas space of the reaction vessel via an NS14.5 core olive. Galvanostatic electrolysis was carried out at a current density of 10 mA/cm 2 at 20 to 30 °C.
- Cyclooctanone According to AAV1, cyclooctane (0.561 g, 5.0 mmol, 1.0 eq.) was dissolved in acetonitrile (25 mL) and electrolyzed galvanostatically at 30 °C under an oxygen atmosphere with the application of 4 F. After workup according to AAV1, the product was obtained as a colorless liquid (yield: 42%, 0.261 g, 2.07 mmol).
- AAV2a The electrolyses were carried out in an undivided 5 mL PTFE cell.
- the conductive salt (0.2 to 1.0 eq.) and the substrate (cyclooctane, 0.5-2.5 mmol) were placed in the cell and dissolved in the solvent (5 mL).
- the cell was equipped with a glassy carbon anode and cathode, which had a distance of 0.5 cm (electrode dimension: 7 cm x 1 cm x 0.3 cm, immersion area 1.8 cm 2 ).
- the cells were fixed in a heatable/coolable stainless steel block and supplied with the gas mixture to be examined (100 vol.% O 2 to 0 vol.% O 2 ) via an adapter.
- the electrolysis was carried out with constant current intensity, with the current densities (5-60 mA/cm 2 ), temperatures (5-50 ° C), stirring speeds (100-600 rpm) and amounts of charge (4-8 F) being varied. After applying the charge amount, 2 drops of the reaction solution were removed for gas chromatographic analysis. 1,3,5-trimethoxybenzene is then added to the solution as an NMR standard (1 eq.) and the solvent is removed by distillation (45 ° C, 200 mbar). The yield of the cycloalkanone product was determined using 1 H NMR analysis.
- AAV2b The electrolyses were carried out in an undivided 5 mL PTFE cell.
- the conductive salt (0.2-1.0 eq.) and the substrate (cyclooctane, 0.5-2.5 mmol) were placed in the cell and dissolved in the solvent (5 mL).
- the cell was equipped with a glassy carbon anode and cathode, which had a distance of 0.5 cm (electrode dimension: 7 cm x 1 cm x 0.3 cm, immersion area 1.8 cm 2 ).
- the cells were fixed in a heatable/coolable stainless steel block and supplied with the gas mixture to be examined (100 vol.% O 2 to 0 vol.% O 2 ) via an adapter.
- the electrolysis was carried out with constant current intensity, with varying current densities (5-60 mA/cm 2 ), temperatures (5-50 °C), stirring speeds (100-600 rpm) and amounts of charge (4-8 F).
- 10 mg of 1,3,5-trimethoxybenzene was added to the reaction solution as an internal standard.
- Three drops of the reaction solution were removed for gas chromatographic analysis and quantification of the product. These were eluted using ethyl acetate over approx. 330 mg of 60 M silica gel.
- Approximately 1.5 mL of the filtrate was collected in a GC vial, which was examined for oxidation products using GC-FID and GC-MS.
- the quantification was carried out via a previous calibration of the gas chromatograph.
- the current density was varied in the range 5 mA/cm 2 to 60 mA/cm 2 .
- the electrode area in the electrolyte solution was 1.8 cm 2 .
- 6-AAV2a-06 100:0 48 ⁇ 0 19 ⁇ 1 1 ⁇ 0 1 ⁇ 0 6-AAV2a-08 8:80 p.m 22 ⁇ 2 5 ⁇ 1 5 ⁇ 0 0 ⁇ 0 6-AAV2a-09 0:100 - 0 ⁇ 0 Sense - Const.: GK
- 6-AAV2a-01 100:0 42 ⁇ 8 16 ⁇ 1 1 ⁇ 0 1 ⁇ 0 6-AAV2a-10 50:50 35 ⁇ 4 15 ⁇ 3 1 ⁇ 0 1 ⁇ 0 6-AAV2a-11 35:65 55 ⁇ 3 9 ⁇ 1 2 ⁇ 0 0 ⁇ 0 6-AAV2a-12 Air (approx.
- 6-AAV2a-16 0.5 1:0.5 21 ⁇ 2 30 ⁇ 1 2 ⁇ 0 4 ⁇ 0 6-AAV2a-17 0.5 1:1.0 18 ⁇ 2 30 ⁇ 1 1 ⁇ 0 6 ⁇ 1 6-AAV2a-18 1.0 1:0.2 20 ⁇ 2 26 ⁇ 2 2 ⁇ 0 4 ⁇ 1 6-AAV2a-13 1.0 1:0.5 12 ⁇ 4 31 ⁇ 2 1 ⁇ 0 6 ⁇ 1 6-AAV2a-19 1.0 1:1.0 10 ⁇ 1 27 ⁇ 1 1 ⁇ 0 4 ⁇ 1 6-AAV2a-20 2.5 1:0.2 11 ⁇ 3 23 ⁇ 0 1 ⁇ 0 4 ⁇ 0 6-AAV2a-21 2.5 1:0.5 11 ⁇ 2 22 ⁇ 0 1 ⁇ 0 4 ⁇ 0 Const.: GK
- 6-AAV2a-22 600 30 ⁇ 1 7 ⁇ 1 1 ⁇ 0 0 ⁇ 0 6-AAV2a-23 500 26 ⁇ 4 8 ⁇ 0 2 ⁇ 0 0 ⁇ 0 6-AAV2a-13 350 12 ⁇ 4 31 ⁇ 2 1 ⁇ 0 6 ⁇ 1 6-AAV2a-24 200 28 ⁇ 3 17 ⁇ 1 2 ⁇ 0 1 ⁇ 0 6-AAV2a-25 100 29 ⁇ 4 8 ⁇ 0 4 ⁇ 0 0 ⁇ 0 Const.: GK
- the temperatures given refer to heating block or cryostat temperatures.
- the electrolyte solutions were stirred at 5 °C and 50 °C for approximately half an hour before electrolysis began. ⁇ b>Table 5: ⁇ /b> Investigation of different temperatures.
- 6-AAV2a-26 50 9 ⁇ 1 27 ⁇ 2 1 ⁇ 0 7 ⁇ 1 6-AAV2a-13 30 12 ⁇ 4 31 ⁇ 2 1 ⁇ 0 6 ⁇ 1 6-AAV2a-27 5 17 ⁇ 1 27 ⁇ 2 1 ⁇ 0 4 ⁇ 1 Const.: GK
- Table 8 illustrate the dependence of the reaction on the nitrate anion.
- the product 2 forms only to a very small extent with other conductive salt anions.
- Electrolysis was carried out on various carbon-based electrode materials.
- the electrode materials that deviate from the GK standard were only tested once in an electrolysis, which is why no average value was recorded here.
- the cycloalkane (5.0 mmol) and tetrabutylammonium nitrate (0.5 eq.) were dissolved in acetonitrile (25 mL) in an undivided 25 mL glass beaker cell with a gas inlet attachment.
- the cell was equipped with glassy carbon electrodes (7 cm x 1 cm x 0.3 cm) at a distance of 0.5 to 1.0 cm.
- the immersion area of the electrodes was 1.3 cm 2 .
- Galvanostatic electrolysis was carried out at a current density of 10 mA/cm 2 at 20-30 °C.
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Materials Engineering (AREA)
- Metallurgy (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP22164767.0A EP4253603A1 (fr) | 2022-03-28 | 2022-03-28 | Oxydation électrochimique des cycloalcanes en composés de cycloalkanone |
PCT/EP2023/057342 WO2023186659A1 (fr) | 2022-03-28 | 2023-03-22 | Oxydation électrochimique de cycloalcanes pour former des composés cycloalcanones |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP22164767.0A EP4253603A1 (fr) | 2022-03-28 | 2022-03-28 | Oxydation électrochimique des cycloalcanes en composés de cycloalkanone |
Publications (1)
Publication Number | Publication Date |
---|---|
EP4253603A1 true EP4253603A1 (fr) | 2023-10-04 |
Family
ID=80978841
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP22164767.0A Ceased EP4253603A1 (fr) | 2022-03-28 | 2022-03-28 | Oxydation électrochimique des cycloalcanes en composés de cycloalkanone |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP4253603A1 (fr) |
WO (1) | WO2023186659A1 (fr) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104032327B (zh) * | 2014-06-26 | 2016-06-15 | 天津工业大学 | 一种电化学催化氧化环己烷制备环己醇及环己酮的方法 |
JP2019099861A (ja) * | 2017-11-30 | 2019-06-24 | 国立研究開発法人産業技術総合研究所 | シクロアルカノール及びシクロアルカノンの製造方法 |
WO2021260679A1 (fr) * | 2020-06-22 | 2021-12-30 | Yeda Research And Development Co. Ltd | Oxydation électrocatalytique aérobie d'hydrocarbures |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4029068A1 (de) * | 1990-09-13 | 1992-03-19 | Hoechst Ag | Verfahren zur herstellung von halogenierten acrylsaeuren |
-
2022
- 2022-03-28 EP EP22164767.0A patent/EP4253603A1/fr not_active Ceased
-
2023
- 2023-03-22 WO PCT/EP2023/057342 patent/WO2023186659A1/fr unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104032327B (zh) * | 2014-06-26 | 2016-06-15 | 天津工业大学 | 一种电化学催化氧化环己烷制备环己醇及环己酮的方法 |
JP2019099861A (ja) * | 2017-11-30 | 2019-06-24 | 国立研究開発法人産業技術総合研究所 | シクロアルカノール及びシクロアルカノンの製造方法 |
WO2021260679A1 (fr) * | 2020-06-22 | 2021-12-30 | Yeda Research And Development Co. Ltd | Oxydation électrocatalytique aérobie d'hydrocarbures |
Non-Patent Citations (5)
Title |
---|
A. KIRSTEG. SCHNAKENBURGF. STECKERA. FISCHERS. R. WALDVOGEL, ANGEW. CHEM. INT. ED., vol. 49, 2010, pages 971 - 975 |
ANGEW. CHEM., vol. 122, 2010, pages 983 - 987 |
C. GÜTZB. KLÖCKNERS. R. WALDVOGEL, ORG. PROCESS RES. DEV., vol. 20, 2016, pages 26 - 32 |
KAWAMATA, J. AM. CHEM. SOC., vol. 139, 2017, pages 7448 - 7551 |
YAMANAKA, J. CHEM. COMMUN., 2000, pages 2209 - 2210 |
Also Published As
Publication number | Publication date |
---|---|
WO2023186659A1 (fr) | 2023-10-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP2964811B1 (fr) | Couplage électrochimique d'anilines | |
EP3337801B1 (fr) | Procédé de préparation de (4s)-4-(4-cyano-2-méthoxyphényl)-5-éthoxy-2,8-diméthyl-1,4-dihydro-1,6-naphtyridine-3-carboxamide et de récupération de (4s)-4-(4-cyano-2-méthoxyphényl)-5-éthoxy-2,8-diméthyl-1,4-dihydro-1,6-naphtyridine-3-carboxamide au moyen de méthodes électrochimiques | |
Barnes et al. | Electrochemical oxidation of primary aliphatic amines | |
EP2964810B1 (fr) | Procédé électrochimique de couplage de phénol à aniline | |
WO2014135236A1 (fr) | Couplage électrochimique de deux phénols ayant des potentiels d'oxydation différents | |
DE19809532C1 (de) | Verfahren zur Carboxylierung von terminalen Alkinen | |
WO2016062424A1 (fr) | Procédé de fabrication de carbonate d'acide glycérique | |
DE2301032A1 (de) | Verfahren und vorrichtung zur herstellung von oxalsaeure durch elektrochemische reduktion von kohlendioxid | |
DE3130805A1 (de) | Neue ruthenium/kohle-hydrierkatalysatoren, deren herstellung und verwendung zur selektiven hydrierung von ungesaettigten carbonylverbindungen | |
EP0085763B1 (fr) | Procédé de préparation de dérivés cyclohexéniques | |
DE69319342T2 (de) | Elektrokatalytische asymmetrische dihydroxylierung von olefinen | |
EP2964812B1 (fr) | Couplage électrochimique d'un phénol à un naphthol | |
EP1348043A2 (fr) | Procede de production de liaisons carbonyle alcoxylees par oxydation anodique et reaction de couplage cathodique pour realiser une synthese organique | |
EP4253603A1 (fr) | Oxydation électrochimique des cycloalcanes en composés de cycloalkanone | |
EP2041336B1 (fr) | Fabrication électrochimique d'amines à encombrement stérique | |
EP0017907B1 (fr) | Procédé de préparation de dérivés du cyclohexène | |
EP2411564B1 (fr) | Procédé électrochimique de production de 3-tert-butylbenzaldehyde-dimetylacetals | |
DE2920562C2 (fr) | ||
WO2023186661A1 (fr) | OXYDATION ÉLECTROCHIMIQUE DE CYCLOALCÈNES ET DE CYCLOALCANES EN ACIDES α,ω-DICARBOXYLIQUES OU EN ACIDES CÉTOCARBOXYLIQUES ET EN COMPOSÉS CYCLOALCANONE | |
EP0702998B1 (fr) | Procédé de préparation de composés cétoniques | |
WO2023186658A1 (fr) | Oxydation électrochimique de cycloalcènes pour former des acides alpha, oméga-dicarboxyliques et des acides cétocarboxyliques | |
EP0172519B1 (fr) | Procédé pour la préparation d'ionones | |
DE60107281T2 (de) | Elektrochemisches verfahren zur selektiven umsetzung von alkylaromatischen verbindungen zu aldehyden | |
DE10121057A1 (de) | Verfahren zur Herstellung von Ketonen | |
DE2953189C1 (de) | Verfahren zur Herstellung von Ketonen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN PUBLISHED |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED |
|
18R | Application refused |
Effective date: 20231022 |