EP4218996B1 - Mixing apparatus, mixing system and method for mixing substances in closed containers - Google Patents
Mixing apparatus, mixing system and method for mixing substances in closed containers Download PDFInfo
- Publication number
- EP4218996B1 EP4218996B1 EP23159223.9A EP23159223A EP4218996B1 EP 4218996 B1 EP4218996 B1 EP 4218996B1 EP 23159223 A EP23159223 A EP 23159223A EP 4218996 B1 EP4218996 B1 EP 4218996B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- mixing apparatus
- plate
- retainer
- containers
- base plate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title claims description 10
- 239000000126 substance Substances 0.000 title description 9
- 238000003780 insertion Methods 0.000 claims description 14
- 230000037431 insertion Effects 0.000 claims description 14
- 239000012530 fluid Substances 0.000 claims description 8
- 241000047428 Halter Species 0.000 description 11
- 125000006850 spacer group Chemical group 0.000 description 5
- 230000000295 complement effect Effects 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- FIKFLLIUPUVONI-UHFFFAOYSA-N 8-(2-phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one;hydrochloride Chemical compound Cl.O1C(=O)NCC11CCN(CCC=2C=CC=CC=2)CC1 FIKFLLIUPUVONI-UHFFFAOYSA-N 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- 239000003708 ampul Substances 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000004091 panning Methods 0.000 description 1
- 239000013610 patient sample Substances 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/20—Mixing the contents of independent containers, e.g. test tubes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/20—Mixing the contents of independent containers, e.g. test tubes
- B01F31/23—Mixing the contents of independent containers, e.g. test tubes by pivoting the containers about an axis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/20—Mixing the contents of independent containers, e.g. test tubes
- B01F31/201—Holders therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/20—Measuring; Control or regulation
- B01F35/22—Control or regulation
- B01F35/221—Control or regulation of operational parameters, e.g. level of material in the mixer, temperature or pressure
- B01F35/2214—Speed during the operation
- B01F35/22142—Speed of the mixing device during the operation
- B01F35/221422—Speed of rotation of the mixing axis, stirrer or receptacle during the operation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/30—Driving arrangements; Transmissions; Couplings; Brakes
- B01F35/32—Driving arrangements
- B01F35/325—Driving reciprocating or oscillating stirrers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/40—Mounting or supporting mixing devices or receptacles; Clamping or holding arrangements therefor
- B01F35/42—Clamping or holding arrangements for mounting receptacles on mixing devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
Definitions
- the present invention relates to a mixing apparatus, in particular for mixing substances in closed containers.
- ampoules can be arranged on a swivel table that can be swiveled by means of a drive.
- the swivel table comprises individual specific holders for ampoules with different diameters or the swivel table comprises a pattern of fingers that protrude from the table top of the swivel table and between which different ampoules can be arranged, with smaller ampoules rolling back and forth between the fingers when swiveled.
- a holder for ampoules is mounted on two sides so that it can rotate, and the holder can be pivoted by means of a drive.
- An ampoule can be inserted into each container receptacle of the holder.
- One object of the present invention is to provide a mixing apparatus in which the risk of confusion is reduced and in which the insertion and removal of the containers containing substances to be mixed is facilitated.
- the confusion of containers is to be avoided, particularly in the case of patient samples.
- a mixing apparatus comprises a drive unit with a drive and with a shaft that can be pivoted about a pivot axis and is operatively connected to the drive, a pivot mount that is arranged on the shaft, the pivot axis being aligned substantially horizontally, the pivot mount comprising a base plate and at least one retainer spaced therefrom, the pivot mount being designed in such a way that holders for containers can be inserted in the direction of the pivot axis between the base plate and the at least one retainer.
- the drive unit comprises a housing in which an electro-mechanical drive, with or without a gear, is arranged.
- the drive unit can comprise a belt drive.
- the swivel mount can be swiveled around the swivel axis by any angle in both directions. This means that the swivel mount can be swiveled back and forth by any angle using the drive unit, for example, or the swivel mount can be rotated around the swivel axis once or several times in one of the two directions of rotation.
- Powders or fluids such as suspensions or emulsions, can therefore be mixed.
- whole blood i.e. blood plasma or blood serum
- the substances to be mixed can be filled into test tubes or ampoules.
- Ampoules comprise glass or plastic containers that are closed at the top with a lid that includes a septum.
- the septum comprises a soft plastic, for example made of PTFE or silicone, which can be pierced with a pipette needle or tip.
- a Lids are screwed onto the open-topped container with a thread.
- the mixing device comprises a control unit with which the swivel angle, the swivel speed and the swivel direction can be adjusted. By setting these values, an optimal mixture of the substances can be achieved.
- receptacles are provided on the side of the base plate facing the at least one retainer, which are aligned in the direction of the pivot axis and into which the holders for containers can be inserted.
- the receptacles comprise elevations which can protrude into complementary recesses in the holders.
- the elevations are elements which extend directly from the base plate of the swivel receptacle.
- the elevations can be pins, for example pins with a circular cross-section. However, other cross-sections are also conceivable.
- the elevations can also be slot nuts, for example for T-slots or dovetail grooves.
- the receptacles can comprise recesses into which complementary elevations of the holders can protrude and which also form a pin-groove connection or a slot nut-groove connection.
- the receptacles are arranged one after the other along the pivot axis.
- the receptacles comprise first receptacles which are arranged in a region of the base plate close to the shaft and second receptacles, which are arranged in an area of the base plate remote from the shaft.
- the holders can be inserted with a first end in the first receptacle and with a second end in the second receptacle. The position and orientation of each holder are thus clearly and reliably defined.
- additional mounts can be provided that are aligned with it.
- the additional mounts give the holders additional support or they allow the insertion of shorter holders that do not extend over the entire length of the swivel mount.
- receptacles are arranged next to one another in a direction transverse to the pivot axis. This means that several identical or different holders can be inserted next to one another into the pivot receptacle, whereby the contents of several containers can be mixed simultaneously.
- the receptacles are arranged symmetrically with respect to the pivot axis.
- the mixing apparatus comprises first spacers, which can be inserted into the receptacles and into which the holders for the containers can be inserted, and second spacers, which are arranged between the receptacles and on which the holders for the containers can rest.
- the spacers increase the distance between the inserted holders and the base plate of the swivel receptacle. This is advantageous if shorter vessels are to be inserted into the holders and the upper end the vessels used should have essentially the same distance from the base plate as the longer vessels.
- graduating the thickness of the spacers it is possible to ensure that the upper ends of the common vessels are essentially aligned with one another when they are in the mixer. Different spacers can be arranged on the swivel mount at the same time, which means that different vessels can be arranged in the mixer at the same time and their upper ends are essentially aligned with one another.
- a drive plate is provided in a first end region of the base plate, which is aligned substantially perpendicular to the base plate and substantially perpendicular to the pivot axis and which connects the shaft to the base plate.
- the base plate is connected to the at least one retainer through the drive plate.
- a support element is provided in a second end region of the base plate opposite the first end region, which support element comprises a cylindrical outer surface whose axis is congruent with the pivot axis.
- the base plate is connected to the at least one retainer by the support element.
- the support element comprises a plate which is aligned substantially perpendicular to the base plate and the pivot axis.
- the support element comprises a central opening and the base plate protrudes at least partially through the central opening.
- At least one connector is provided which connects the drive plate to the support element.
- the drive plate comprises at least one groove for receiving the at least one retainer.
- elevations can be provided on the drive plate in which the at least one retainer is held or with which the at least one retainer is guided or clamped.
- elevations can be ribs or pins.
- the support element comprises at least one fixing for fastening the at least one retainer.
- a fixing can comprise an at least partially detachable element.
- the fixing can be pivotable and can comprise a fixing element.
- a fixing can also be provided on the drive plate, with which the at least one retainer can be detachably fastened.
- the mixing apparatus comprises a bearing unit with at least one roller on which the support element is rotatably mounted with the outer surface.
- the bearing unit is located with respect to the pivoting mount of the Drive unit opposite.
- the support element is pivotably mounted in the bearing unit, flush with the shaft. Because the pivot mount is mounted on both sides, the corresponding bearings and the pivot mount do not have to be dimensioned as stable, which means that they take up less space and less mass has to be moved.
- the bearing unit comprises two or more rollers on which the support element is rotatably mounted with the outer surface. At least one of the rollers can be spring-mounted. At least one of the rollers can be driven synchronously with the drive unit.
- the drive unit and the bearing unit are arranged on a common connecting plate.
- the connecting plate can be designed to be completely closed or it can comprise at least one recess in the area of the pivot mount.
- the at least one retainer comprises at least one plate with at least one through-opening, wherein the through-openings are arranged such that, when the holders are inserted, they are aligned with the container receptacles formed in the holders.
- the inner dimensions of the through openings are smaller than the inner dimensions of the container receptacles of the insertable holders.
- the inner dimensions of the through opening can also be smaller than the outer dimensions of the lid of the container.
- the at least one retainer comprises a first plate and a second plate, wherein the distance between the base plate and the first plate is greater than that between the base plate and the second plate.
- the two plates can be independent of each other or can be connected to each other.
- the first plate and the second plate are integrally formed together.
- At least one tab is integrally formed and substantially flush with the at least one plate.
- At least one rib is formed integrally with the at least one plate, which extends along the pivot axis over at least a portion of the at least one plate.
- the at least one rib can be formed in one or both lateral edge regions of each plate. Alternatively or additionally, ribs can be arranged between the two edge regions of each plate.
- At least one tab is formed integrally with the at least one rib and spaced parallel to the at least one plate.
- the at least one tab can be arranged in one or both of the two free ends of the retainer.
- the mixing apparatus comprises at least one encoder with which the position of the swivel mount can be determined.
- the mixing apparatus comprises at least one locking device with which the position of the pivoting mount can be fixed.
- the mixing apparatus comprises at least one holder for containers, which is inserted between the base plate and the at least one retainer.
- the at least one holder can additionally be inserted into the receptacles.
- each holder comprises a plurality of container receptacles arranged along a longitudinal axis, which are formed between the two ends.
- the container receptacles can, for example, be countersunk holes with a circular cross-section. However, other cross-sections are also possible.
- Each container receptacle can comprise at least one lateral opening, which extends laterally outwards from the respective container receptacle transversely to the longitudinal axis. The at least one opening can be a slot or a window.
- Each container receptacle can comprise two lateral openings, which are arranged opposite one another with respect to the longitudinal axis and which, together with the container receptacle, form a passage in the holder.
- Each container receptacle can therefore be assigned a slot and a window, two slots or two windows.
- a clamping tab can be provided for each container receptacle, or for each window of the holder, which protrudes through the window into the respective container receptacle, whereby a container received therein can be held in a clamped manner.
- a tab plate can be provided on the holder. which encompasses all clamping tabs.
- the clamping tabs can be formed integrally with the rest of the holder.
- the mentioned designs of the mixing apparatus can be used in any combination, provided they do not contradict each other.
- a mixing plant according to the invention comprises a machine stand on which a mixing apparatus according to the invention is arranged.
- the mixing plant can comprise a work surface which is arranged on the machine stand and wherein the mixing apparatus is arranged on the work surface.
- the mixing system comprises a pipetting unit with which fluids can be added to or removed from containers located in the mixing apparatus.
- the pipetting unit comprises a transport unit on which pipette tips are arranged and with which the pipette tips can be moved horizontally and/or vertically in an area above the machine stand or above the work surface.
- the mixing system comprises a reading unit with which markings on the containers to be received by the mixing apparatus can be read.
- the markings can be selected from the group comprising 1D barcode, 2D barcode, RFID tag and the like.
- the reading unit can also recognize markings which are attached to the holders for receiving the containers. With The reading unit also shows in which position the container holder has a container and which position is empty. It is also possible to see whether all the container holders inserted into the mixer are completely inserted between the base plate and the retainer.
- the insertion can be an insertion, for example if the swivel mount comprises cylindrical pins and the holder is provided with corresponding complementary holes.
- the insertion can also be a pushing in, for example if the swivel mount comprises sliding blocks and the holder is provided with a corresponding complementary groove.
- fastening elements that fix the retaining element in the corresponding receptacles can be removed and the retaining element can then be lifted off and placed in another location independently of the mixing device.
- the retaining element can be pushed linearly away from the area above the swivel mount using a sliding mechanism.
- the retaining element can be pivoted away from the area above the swivel mount in a plane using a twisting mechanism. If the retaining element is fixed to the swivel mount, then the holder under the retaining element must be pushed into the swivel mount, for example along the swivel axis.
- the contents of a mother tube which contains whole blood, for example, can be mixed on its own or with additional substances.
- part of the whole blood can be pipetted from the mother tube to a daughter tube.
- the daughter tube can be empty beforehand or can contain a substance, such as a reagent.
- the contents of the daughter tube can then be mixed again.
- the holder with the containers arranged in it can be removed from the mixing device and fed into an analysis device.
- To remove and/or add fluids from containers that are closed by a lid that includes a septum it is necessary to pierce the septum, for example with a pipette needle.
- the Figure 1 shows a perspective view of a mixing apparatus 100 according to the invention.
- the mixing apparatus 100 comprises a drive unit 1 with a drive 10, a control unit 12 and with a shaft 11 which can be pivoted about a substantially horizontal pivot axis A and which is operatively connected to the drive 10.
- the mixing apparatus 100 further comprises a pivot mount 2 which is arranged on the shaft 11.
- the pivot mount 2 comprises a base plate 20 and a retainer 4 spaced therefrom, the pivot mount 2 being designed such that holders 3 for containers can be inserted in the direction of the pivot axis A between the base plate 20 and the retainer 4.
- a circular disk-shaped drive plate 21 connects the shaft 11 to the base plate 20.
- the drive plate 21 is essentially perpendicular to the swivel base A and essentially perpendicular to the base plate 20.
- a circular disk-shaped support plate 22 is provided, which is aligned parallel and flush with the drive plate 21.
- the outer diameters of the two circular disks are essentially identical.
- the retainer 4 in this embodiment a retaining plate with holes, is detachably arranged between the drive plate 21 and the support plate 22.
- the retainer 4 can be fixed with a pivotable fixation 211 and in the Support plate 22 with a pivotable fixation 222.
- elevations 200 in the form of sliding blocks are provided on the base plate 20, on the side facing the retainer 4, elevations 200 in the form of sliding blocks are provided.
- a reading unit 82 with a limiter 83 is provided on the side of the support plate 22 opposite the drive side.
- the reading unit 82 can be used to read markings on the holder 3 and/or on the containers arranged in the holder 3.
- the support plate 22 is supported on two rollers 50 of a bearing unit 5 and is rotatably mounted.
- the drive unit 1, the bearing unit 5, the reading unit 82 and the limiter 83 are arranged on a common connecting plate 6.
- the Figure 2 shows the mixing apparatus 100 of the Figure 1 without the housing and the drive 10 of the drive unit 1, without the retainer 4, without the reading unit 82 and without the limiter 83.
- the drive plate 21 and the support plate 22 are connected to one another by two rod-shaped connectors 23.
- the connectors 23 are designed and arranged such that the retainer 4 can rest evenly on both connectors 23 when installed.
- a pattern of T-slot nuts 200 is arranged on the base plate 20 of the pivot mount 2.
- a double row of T-slot nuts is arranged in both end regions of the base plate 20 and a single row in a central region of the base plate 20.
- Containers 7 are arranged in the inserted holder 3; sample tubes with a pierceable lid are shown, ie with a lid with a pierceable septum.
- the Figure 3A shows the retainer 4 of the Figure 1 .
- the retainer 4 comprises a bent sheet with holes 40, with two first plates 41, or with two edge plates 41 and with a second plate 42, or with a central plate 42.
- the two edge plates 41 are flush with one another and the central plate 42 is parallel to the two edge plates 41.
- Continuous tabs 43 are provided on the two free ends of the retainer 4, which are flush with the corresponding plates.
- Ribs 44 extend essentially along the entire length of the retainer on the lateral outer boundary of the respective edge plate 41. Due to the one-piece design of the retainer 4, the offset of the first plate 41 to the second plate 42 creates a rib 44 in each transition area.
- the Figure 3B shows an alternative embodiment of the retainer 4 of the Figure 1 with only a first plate 41 and a second plate 42.
- Separate tabs 43 are provided, which are arranged only at one of the two free ends of the retainer.
- only one rib 44 is formed in the transition area between the two plates 41, 42.
- the Figure 3C shows a sectional view of the mixing apparatus 100 of the Figure 1 transverse to the axis A, by a high container 7 and by a low container 70.
- the high container 7 is inserted between the base plate 20 and the first plate 41 of the retainer 4 and the low Container 70 between the base plate 20 and the second plate 42 of the retainer 4.
- the Figure 4 shows a perspective view of a second embodiment of a swivel mount 2 with an alternative retainer 400.
- Grooves 210 are provided in the drive plate 21, into which the retainers 400 can be inserted.
- a fixation 222 is provided on the support plate 22, with which the retainers 400 can be detachably fastened.
- the connectors 23 are designed as laterally arranged round rods.
- a central opening 221 is provided in the support plate 22, through which the base plate 20 protrudes and through which the holders for containers can be inserted.
- holders with high containers can be inserted into the retainers 400. If deeper containers are to be inserted, the retainers 400 must be rotated by 180 degrees so that the outward-facing surface of the plate 401 faces the base plate 20 and that the open end of the retainer 400 faces the drive plate 21.
- the Figure 5 shows a perspective bottom view of the retainer 400 of the Figure 4 .
- the retainer 400 comprises a plate 401 with a slot 402 which extends substantially over the entire length of the plate.
- the width of the slot 402 is smaller than the external dimensions of the container closures and is larger than the piercing area of the container closures.
- ribs 403 extend over substantially the entire length of the Retainer 400.
- a first free end of the retainer 400 is open and a second free end opposite the first free end is laterally closed.
- a first tab 404 is provided at the open end of the retainer 400, which is parallel and slightly offset to the plate 401 in the region of the plate 401 and protrudes beyond the latter at the first free end of the retainer 400.
- a second tab 405 is provided at the closed end of the retainer 400, which is parallel and slightly offset to the ribs 403 in the region of the ribs and protrudes beyond the latter at the second free end of the retainer.
- the Figure 6 shows a holder with containers inserted into it as in the Figure 2 .
- the holder 3 extends along the longitudinal axis L, has container receptacles 32 which comprise two lateral slots 320 and has clamping tabs 322 which are formed integrally with the rest of the holder 3 and which protrude into the interior of the container receptacles 32.
- the holder 3 comprises a groove 33 which is arranged on the underside of the holder 3, i.e. on the side of the holder 3 which is opposite the container receptacles 32.
- a T-slot is shown.
- a dovetail groove or another retaining groove can also be provided.
- the groove 33 extends along the longitudinal axis L, at least over the area of the holder 3 which comprises the container receptacles 32.
- the groove 33 is open at the first end 30 of the holder 3 so that the elevations 200 of the pivot receptacle 2 can be easily inserted into the groove 33.
- a handle 34 is arranged, with by which the holder 3 can be easily grasped by hand.
- a recess 340 is provided in the handle 34, which enables the reading unit 82 to recognize that the holder 3 is completely inserted into the pivoting receptacle 2.
- the Figure 7 shows a perspective view of a mixing system with a mixing apparatus 100 according to the invention, which is pivoted and a non-pivoted mixing apparatus 100. Both apparatuses are arranged with receiving elements 800 on the work surface 80, which are arranged on the machine stand 8.
- the mixing system further comprises the pipetting unit 81 with the transport unit 810 and the pipette tips 811.
- the transport unit 810 can move the pipette tips 811 over the work surface 80 in a first horizontal direction X, in a second horizontal direction Y and in a vertical direction Z.
- the reading unit 82 and the limiter 83 are arranged next to the mixing devices 100 on the work surface 80.
- the reading unit 82 is also aligned and fastened with the receiving elements 800 on the work surface 80. In front of the reading unit 82, holders can be pushed over the receiving elements 800 in order to recognize the markings on the holders 3 and/or on the containers arranged in the holders 3.
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Accessories For Mixers (AREA)
Description
Die vorliegende Erfindung betrifft einen Mischapparat, insbesondere zum Mischen von Substanzen in geschlossenen Behältern.The present invention relates to a mixing apparatus, in particular for mixing substances in closed containers.
Aus dem Stand der Technik sind Mischapparate bekannt, bei welchen beispielsweise Stechampullen auf einem Schwenktisch angeordnet werden können, welcher mittels eines Antriebes schwenkbar ist. Der Schwenktisch umfasst einzelne spezifische Halter für Ampullen mit unterschiedlichen Durchmessern oder der Schwenktisch umfasst ein Muster von Fingern, welche von der Tischplatte des Schwenktisches abstehen und zwischen welchen unterschiedliche Ampullen anordbar sind, wobei kleinere Ampullen beim Schwenken zwischen den Fingern hin- und her rollen.Mixing devices are known from the prior art in which, for example, ampoules can be arranged on a swivel table that can be swiveled by means of a drive. The swivel table comprises individual specific holders for ampoules with different diameters or the swivel table comprises a pattern of fingers that protrude from the table top of the swivel table and between which different ampoules can be arranged, with smaller ampoules rolling back and forth between the fingers when swiveled.
Bei einem anderen bekannten Mischapparat ist ein Halter für Ampullen auf zwei Seiten drehbar gelagert, wobei der Halter mittels eines Antriebs schwenkbar ist. In jeder Behälteraufnahme des Halters kann eine Ampulle eingesetzt werden.In another known mixing device, a holder for ampoules is mounted on two sides so that it can rotate, and the holder can be pivoted by means of a drive. An ampoule can be inserted into each container receptacle of the holder.
Bei solchen Mischapparaten besteht das Risiko, dass die Ampullen vor oder währen dem Einsetzen in den Halter verwechselt werden oder dass die Ampullen beim Entfernen aus dem Halter verwechselt werden. Zudem sind das Einsetzen und das Entfernen der Ampullen zeitaufwändig.With such mixing devices there is a risk that the ampoules are mixed up before or during insertion into the holder or that the ampoules are from the holder. In addition, inserting and removing the ampoules is time-consuming.
Dokument
Eine Aufgabe der vorliegenden Erfindung besteht darin, einen Mischapparat bereitzustellen, bei welchem die Vertauschungsgefahr reduziert ist und bei welchem das Einsetzen und Entfernen der Behälter, welche zu mischende Substanzen beinhalten, erleichtert ist. Besonders bei Patientenproben ist das Vertauschen der Behälter zu vermeiden.One object of the present invention is to provide a mixing apparatus in which the risk of confusion is reduced and in which the insertion and removal of the containers containing substances to be mixed is facilitated. The confusion of containers is to be avoided, particularly in the case of patient samples.
Diese Aufgabe wird durch den Mischapparat mit den Merkmalen des Anspruchs 1 gelöst. Weitere Ausführungsformen des Mischapparats, einer Mischanlage, sowie eines Verfahrens zum Betrieb eines Mischapparates oder einer Mischanlage sind durch die Merkmale von weiteren Ansprüchen definiert. Ein erfindungsgemässer Mischapparat umfasst eine Antriebseinheit mit einem Antrieb und mit einem um eine Schwenkachse schwenkbaren Schaft, welcher mit dem Antrieb wirkverbunden ist, eine Schwenkaufnahme, welche am Schaft angeordnet ist, wobei die Schwenkachse im Wesentlichen horizontal ausgerichtet ist, wobei die Schwenkaufnahme eine Basisplatte und mindestens einen dazu beabstandeten Rückhalter umfasst, wobei die Schwenkaufnahme derart ausgestaltet ist, dass Halter für Behälter in der Richtung der Schwenkachse zwischen die Basisplatte und den mindestens einen Rückhalter einführbar sind. Mit einer solchen Ausgestaltung ist es möglich, die Behälter unabhängig vom Mischapparat, d.h. vor dem Einführen in den Mischapparat in den Halter einzusetzen. Das Einführen kann daher in kurzer Zeit erfolgen. Zudem kann es beim Einführen zu keinen Verwechslungen der Behälter kommen, da diese zuvor ohne Zeitdruck in einem Halter angeordnet werden können. Das Einführen der Halter mit den Behältern in der Richtung der Schwenkachse ist sehr einfach und ergonomisch. Die Antriebseinheit umfasst ein Gehäuse, in welchem ein elektro-mechanischer Antrieb, mit oder ohne Getriebe angeordnet ist. Die Antriebseinheit kann einen Riemenantrieb umfassen.This object is achieved by the mixing apparatus with the features of claim 1. Further embodiments of the mixing apparatus, a mixing system, and a method for operating a mixing apparatus or a mixing system are defined by the features of further claims. A mixing apparatus according to the invention comprises a drive unit with a drive and with a shaft that can be pivoted about a pivot axis and is operatively connected to the drive, a pivot mount that is arranged on the shaft, the pivot axis being aligned substantially horizontally, the pivot mount comprising a base plate and at least one retainer spaced therefrom, the pivot mount being designed in such a way that holders for containers can be inserted in the direction of the pivot axis between the base plate and the at least one retainer. With such a design, it is possible to move the containers independently of the mixing apparatus, i.e. before insertion into the Mixing device can be inserted into the holder. This means that insertion can be carried out in a short time. In addition, there is no risk of mixing up the containers when inserting them, as they can be arranged in a holder beforehand without any time pressure. Inserting the holders with the containers in the direction of the swivel axis is very simple and ergonomic. The drive unit comprises a housing in which an electro-mechanical drive, with or without a gear, is arranged. The drive unit can comprise a belt drive.
In einer Ausführungsform ist die Schwenkaufnahme um einen beliebigen Winkel in beide Richtungen um die Schwenkachse schwenkbar. D.h. die Schwenkaufnahme kann beispielsweise mittels der Antriebseinheit um einen beliebigen Winkel hin und her geschwenkt werden oder die Schwenkaufnahme kann in einer der beiden Drehrichtungen einmal oder mehrmals um die Schwenkachse gedreht werden. Dies ermöglicht ein optimales Mischen aller möglichen Substanzen, welche sich in den Behältern befinden können. Es können daher Pulver oder Fluide, wie beispielsweise Suspensionen oder Emulsionen gemischt werden. Beispielsweise kann Vollblut, d.h. Blutplasma oder Blutserum mit Blutzellen für sich oder mit zusätzlichen Substanzen gemischt werden. Beispielsweise können die zu mischenden Substanzen in Reagenzröhrchen oder Stechampullen abgefüllt sein. Stechampullen umfassen Glas- oder Kunststoffbehälter, welche oben mit einem Deckel verschlossen sind, welcher ein Septum umfasst. Das Septum umfasst einen weichen Kunststoff, beispielsweise aus PTFE oder Silikon, welcher mit einer Pipettennadel, bzw. -spitze durchstochen werden kann. Beispielsweise kann ein solcher Deckel auf dem oben offenen Behälter mit einem Gewinde aufgeschraubt werden.In one embodiment, the swivel mount can be swiveled around the swivel axis by any angle in both directions. This means that the swivel mount can be swiveled back and forth by any angle using the drive unit, for example, or the swivel mount can be rotated around the swivel axis once or several times in one of the two directions of rotation. This enables optimal mixing of all possible substances that may be in the containers. Powders or fluids, such as suspensions or emulsions, can therefore be mixed. For example, whole blood, i.e. blood plasma or blood serum, can be mixed with blood cells on its own or with additional substances. For example, the substances to be mixed can be filled into test tubes or ampoules. Ampoules comprise glass or plastic containers that are closed at the top with a lid that includes a septum. The septum comprises a soft plastic, for example made of PTFE or silicone, which can be pierced with a pipette needle or tip. For example, such a Lids are screwed onto the open-topped container with a thread.
In einer Ausführungsform umfasst der Mischapparat eine Steuereinheit, mit welcher der Schwenkwinkel, die Schwenkgeschwindigkeit und die Schwenkrichtung einstellbar sind. Mit der Einstellung dieser Werte kann eine optimale Mischung der Substanzen erreicht werden.In one embodiment, the mixing device comprises a control unit with which the swivel angle, the swivel speed and the swivel direction can be adjusted. By setting these values, an optimal mixture of the substances can be achieved.
In einer Ausführungsform sind auf der gegen den mindestens einen Rückhalter gerichteten Seite der Basisplatte Aufnahmen vorgesehen, welche in der Richtung der Schwenkachse ausgerichtet sind und in welche die Halter für Behälter einführbar sind.In one embodiment, receptacles are provided on the side of the base plate facing the at least one retainer, which are aligned in the direction of the pivot axis and into which the holders for containers can be inserted.
In einer Ausführungsform umfassen die Aufnahmen Erhebungen, welche in dazu komplementäre Ausnehmungen der Halter ragen können. Beispielsweise sind die Erhebungen Elemente, welche sich direkt von der Basisplatte der Schwenkaufnahme an erstrecken. Die Erhebungen können Stifte sein, beispielsweise Stifte mit kreisförmigem Querschnitt. Andere Querschnitte sind jedoch auch denkbar. Die Erhebungen können auch Nutensteine sein, beispielsweise für T-Nuten oder Schwalbenschwanz-Nuten. Alternativ können die Aufnahmen Ausnehmungen umfassen, in welche komplementäre Erhebungen der der Halter ragen können, und welche ebenfalls eine Stift-Nut-Verbindung oder eine Nutstein-Nut-Verbindung bilden.In one embodiment, the receptacles comprise elevations which can protrude into complementary recesses in the holders. For example, the elevations are elements which extend directly from the base plate of the swivel receptacle. The elevations can be pins, for example pins with a circular cross-section. However, other cross-sections are also conceivable. The elevations can also be slot nuts, for example for T-slots or dovetail grooves. Alternatively, the receptacles can comprise recesses into which complementary elevations of the holders can protrude and which also form a pin-groove connection or a slot nut-groove connection.
In einer Ausführungsform sind mehrere Aufnahmen entlang der Schwenkachse nacheinander angeordnet. Beispielsweise umfassen die Aufnahmen erste Aufnahmen, welche in einem Schaft-nahen Bereich der Basisplatte angeordnet sind und zweite Aufnahmen, welche in einem Schaft-fernen Bereich der Basisplatte angeordnet sind. Die Halter sind mit einem ersten Ende in der ersten Aufnahme einführbar und mit einem zweiten Ende in der zweiten Aufnahme. Somit sind die Position und die Ausrichtung jedes Halters eindeutig und zuverlässig festgelegt.In one embodiment, several receptacles are arranged one after the other along the pivot axis. For example, the receptacles comprise first receptacles which are arranged in a region of the base plate close to the shaft and second receptacles, which are arranged in an area of the base plate remote from the shaft. The holders can be inserted with a first end in the first receptacle and with a second end in the second receptacle. The position and orientation of each holder are thus clearly and reliably defined.
Zwischen einer der ersten Aufnahmen und einer mit dieser in der Richtung der Schwenkachse fluchtenden zweiten Aufnahmen können weitere mit dieser fluchtende Aufnahmen vorgesehen sein. Die zusätzlichen Aufnahmen geben den Haltern zusätzlichen Halt oder sie erlauben das Einführen von kürzeren Haltern, welche sich nicht über die gesamte Länge der Schwenkaufnahme erstrecken.Between one of the first mounts and a second mount that is aligned with it in the direction of the swivel axis, additional mounts can be provided that are aligned with it. The additional mounts give the holders additional support or they allow the insertion of shorter holders that do not extend over the entire length of the swivel mount.
In einer Ausführungsform sind mehrere Aufnahmen, in einer Richtung quer zur Schwenkachse, nebeneinander angeordnet. Somit können mehrere gleiche oder unterschiedliche Halter nebeneinander in die Schwenkaufnahme eingeführt werden, wodurch der Inhalt mehrere Behälter gleichzeitig gemischt werden kann. Beispielsweise sind die Aufnahmen symmetrisch bezüglich der Schwenkachse angeordnet.In one embodiment, several receptacles are arranged next to one another in a direction transverse to the pivot axis. This means that several identical or different holders can be inserted next to one another into the pivot receptacle, whereby the contents of several containers can be mixed simultaneously. For example, the receptacles are arranged symmetrically with respect to the pivot axis.
In einer Ausführungsform umfasst der Mischapparat erste Distanzhalter, welche in die Aufnahmen einführbar sind und in welche die Halter für die Behälter einführbar sind, und zweite Distanzhalter, welche zwischen den Aufnahmen angeordnet sind und auf welchen die Halter für die Behälter aufliegen können. Mit den Distanzhaltern vergrössert sich der Abstand der eingeführten Halter zur Basisplatte der Schwenkaufnahme. Dies ist vorteilhaft, wenn kürzere Gefässe in die Halter eingesetzt werden sollen und das obere Ende der eingesetzten Gefässe im Wesentlichen den gleichen Abstand zur Basisplatte haben sollte, wie die längeren Gefässe. Durch die Abstufung der Dicke der Distanzhalter ist es möglich zu erreichen, dass die oberen Enden der gängigen Gefässe im Wesentlichen fluchtend miteinander ausgerichtet sind, wenn sie sich im Mischapparat befinden. Es können unterschiedliche Distanzhalter gleichzeitig auf der Schwenkaufnahme angeordnet werden, wodurch unterschiedliche Gefässe gleichzeitig im Mischapparat angeordnet werden können und deren obere Enden im Wesentlichen miteinander fluchten.In one embodiment, the mixing apparatus comprises first spacers, which can be inserted into the receptacles and into which the holders for the containers can be inserted, and second spacers, which are arranged between the receptacles and on which the holders for the containers can rest. The spacers increase the distance between the inserted holders and the base plate of the swivel receptacle. This is advantageous if shorter vessels are to be inserted into the holders and the upper end the vessels used should have essentially the same distance from the base plate as the longer vessels. By graduating the thickness of the spacers, it is possible to ensure that the upper ends of the common vessels are essentially aligned with one another when they are in the mixer. Different spacers can be arranged on the swivel mount at the same time, which means that different vessels can be arranged in the mixer at the same time and their upper ends are essentially aligned with one another.
In einer Ausführungsform ist in einem ersten Endbereich der Basisplatte eine Antriebsplatte vorgesehen, welche im Wesentlichen senkrecht zur Basisplatte und im Wesentlichen senkrecht zur Schwenkachse ausgerichtet ist und welche den Schaft mit der Basisplatte verbindet.In one embodiment, a drive plate is provided in a first end region of the base plate, which is aligned substantially perpendicular to the base plate and substantially perpendicular to the pivot axis and which connects the shaft to the base plate.
In einer Ausführungsform ist die Basisplatte durch die Antriebsplatte mit dem mindestens einen Rückhalter verbunden.In one embodiment, the base plate is connected to the at least one retainer through the drive plate.
In einer Ausführungsform ist in einem dem ersten Endbereich gegenüberliegenden zweiten Endbereich der Basisplatte ein Auflageelement vorgesehen, welches eine zylindrische Mantelfläche umfasst, deren Achse kongruent mit der Schwenkachse ist.In one embodiment, a support element is provided in a second end region of the base plate opposite the first end region, which support element comprises a cylindrical outer surface whose axis is congruent with the pivot axis.
In einer Ausführungsform ist die Basisplatte durch das Auflageelement mit dem mindestens einen Rückhalter verbunden.In one embodiment, the base plate is connected to the at least one retainer by the support element.
In einer Ausführungsform umfasst das Auflageelement eine Platte, welche im Wesentlichen senkrecht zur Basisplatte und zur Schwenkachse ausgerichtet ist.In one embodiment, the support element comprises a plate which is aligned substantially perpendicular to the base plate and the pivot axis.
In einer Ausführungsform umfasst das Auflageelement eine zentrische Öffnung und die Basisplatte ragt zumindest teilweise durch die zentrische Öffnung.In one embodiment, the support element comprises a central opening and the base plate protrudes at least partially through the central opening.
In einer Ausführungsform ist mindestens ein Verbinder vorgesehen, welcher die Antriebsplatte mit dem Auflageelement verbindet.In one embodiment, at least one connector is provided which connects the drive plate to the support element.
In einer Ausführungsform umfasst die Antriebsplatte mindestens eine Nut zur Aufnahme des mindestens einen Rückhalters. Alternativ können Erhebung an der Antriebsplatte vorgesehen sein, in welchen der mindestens eine Rückhalter gehalten wird oder mit welchen der mindestens eine Rückhalter geführt oder geklemmt wird. Beispielsweise können solche Erhebungen Rippen oder Stifte sein.In one embodiment, the drive plate comprises at least one groove for receiving the at least one retainer. Alternatively, elevations can be provided on the drive plate in which the at least one retainer is held or with which the at least one retainer is guided or clamped. For example, such elevations can be ribs or pins.
In einer Ausführungsform umfasst das Auflageelement mindestens eine Fixierung zur Befestigung des mindestens einen Rückhalters. Eine solche Fixierung kann ein zumindest teilweise lösbares Element umfassen. Beispielsweise kann die Fixierung schwenkbar sein und kann ein Fixierelement umfassen. Alternativ oder zusätzlich kann auch bei der Antriebsplatte eine Fixierung vorgesehen sein, mit welche der mindestens eine Rückhalter lösbar befestigbar ist.In one embodiment, the support element comprises at least one fixing for fastening the at least one retainer. Such a fixing can comprise an at least partially detachable element. For example, the fixing can be pivotable and can comprise a fixing element. Alternatively or additionally, a fixing can also be provided on the drive plate, with which the at least one retainer can be detachably fastened.
In einer Ausführungsform umfasst der Mischapparat eine Lagereinheit mit mindestens einer Rolle, auf welcher das Auflageelement mit der Mantelfläche drehbar gelagert ist. Die Lagereinheit liegt bezüglich der Schwenkaufnahme der Antriebseinheit gegenüber. Das Auflageelement ist fluchtend mit dem Schaft in der Lagereinheit schwenkbar gelagert. Durch die beidseitige Lagerung der Schwenkaufnahme müssen die entsprechenden Lager und die Schwenkaufnahme wenige stabil dimensioniert sein, wodurch sie weniger Platz brauchen und wodurch weniger Masse bewegt werden muss.In one embodiment, the mixing apparatus comprises a bearing unit with at least one roller on which the support element is rotatably mounted with the outer surface. The bearing unit is located with respect to the pivoting mount of the Drive unit opposite. The support element is pivotably mounted in the bearing unit, flush with the shaft. Because the pivot mount is mounted on both sides, the corresponding bearings and the pivot mount do not have to be dimensioned as stable, which means that they take up less space and less mass has to be moved.
In einer Ausführungsform umfasst die Lagereinheit zwei oder mehr Rollen, auf welchen das Auflageelement mit der Mantelfläche drehbar gelagert ist. Mindestens eine der Rollen kann federnd gelagert sein. Mindestens eine der Rollen kann synchron zur Antriebseinheit angetrieben sein.In one embodiment, the bearing unit comprises two or more rollers on which the support element is rotatably mounted with the outer surface. At least one of the rollers can be spring-mounted. At least one of the rollers can be driven synchronously with the drive unit.
In einer Ausführungsform sind die Antriebseinheit und die Lagereinheit auf einer gemeinsamen Verbindungsplatte angeordnet. Die Verbindungsplatte kann durchgängig geschlossen ausgebildet sein oder sie kann mindestens eine Ausnehmung im Bereich der Schwenkaufnahme umfassen.In one embodiment, the drive unit and the bearing unit are arranged on a common connecting plate. The connecting plate can be designed to be completely closed or it can comprise at least one recess in the area of the pivot mount.
Erfindungsgemäss umfasst der mindestens eine Rückhalter mindestens eine Platte mit mindestens einer Durchgangsöffnung, wobei die Durchgangsöffnungen derart angeordnet sind, dass sie bei eingeführten Haltern, fluchtend mit den in den Haltern ausgebildeten Behälteraufnahmen ausgerichtet sind.According to the invention, the at least one retainer comprises at least one plate with at least one through-opening, wherein the through-openings are arranged such that, when the holders are inserted, they are aligned with the container receptacles formed in the holders.
In einer Ausführungsform sind die inneren Abmessungen der Durchgangsöffnungen kleiner als die inneren Abmessungen der Behälteraufnahmen der einführbaren Halter. Die innere Abmessung der Durchgangsöffnung können auch kleiner sein als die äusseren Abmessungen des Deckels der Behälter.In one embodiment, the inner dimensions of the through openings are smaller than the inner dimensions of the container receptacles of the insertable holders. The inner dimensions of the through opening can also be smaller than the outer dimensions of the lid of the container.
Erfindungsgemäss umfasst der mindestens eine Rückhalter eine erste Platte und eine zweite Platte, wobei der Abstand zwischen der Basisplatte und der ersten Platte grösser ist als derjenige zwischen der Basisplatte und der zweiten Platte. Die beiden Platten können unabhängig voneinander sein oder können miteinander verbunden sein.According to the invention, the at least one retainer comprises a first plate and a second plate, wherein the distance between the base plate and the first plate is greater than that between the base plate and the second plate. The two plates can be independent of each other or can be connected to each other.
In einer Ausführungsform sind die erste Platte und die zweite Platte gemeinsam einstückig miteinander ausgebildet.In one embodiment, the first plate and the second plate are integrally formed together.
In einer Ausführungsform ist mindestens eine Lasche gemeinsam einstückig und im Wesentlichen fluchtend mit der mindestens einen Platte ausgebildet.In one embodiment, at least one tab is integrally formed and substantially flush with the at least one plate.
In einer Ausführungsform ist mindestens eine Rippe gemeinsam einstückig mit der mindestens einen Platte ausgebildet, welche sich entlang der Schwenkachse über mindestens einen Bereich der mindestens einen Platte erstreckt. Die mindestens eine Rippe kann in einem oder beiden seitlichen Randbereichen einer jeden Platte ausgebildet sein. Alternativ oder zusätzlich können Rippen zwischen den beiden Randbereichen einer jeden Platte angeordnet sein.In one embodiment, at least one rib is formed integrally with the at least one plate, which extends along the pivot axis over at least a portion of the at least one plate. The at least one rib can be formed in one or both lateral edge regions of each plate. Alternatively or additionally, ribs can be arranged between the two edge regions of each plate.
In einer Ausführungsform ist mindestens eine Lasche gemeinsam einstückig mit der mindestens einen Rippe und parallel beabstandet zur mindestens einen Platte ausgebildet. Die mindestens eine Lasche kann in einem oder beiden der beiden freien Enden des Rückhalters angeordnet sein.In one embodiment, at least one tab is formed integrally with the at least one rib and spaced parallel to the at least one plate. The at least one tab can be arranged in one or both of the two free ends of the retainer.
In einer Ausführungsform umfasst der Mischapparat mindestens einen Encoder, mit welchem die Lage der Schwenkaufnahme bestimmbar ist.In one embodiment, the mixing apparatus comprises at least one encoder with which the position of the swivel mount can be determined.
In einer Ausführungsform umfasst der Mischapparat mindestens eine Arretierung, mit welchem die Lage der Schwenkaufnahme fixierbar ist.In one embodiment, the mixing apparatus comprises at least one locking device with which the position of the pivoting mount can be fixed.
In einer Ausführungsform umfasst der Mischapparat mindestens einen Halter für Behälter, welcher zwischen der Basisplatte und dem mindestens einen Rückhalter eingeführt ist. Der mindestens eine Halter kann zusätzlich in den Aufnahmen eingeführt sein.In one embodiment, the mixing apparatus comprises at least one holder for containers, which is inserted between the base plate and the at least one retainer. The at least one holder can additionally be inserted into the receptacles.
In einer Ausführungsform umfasst jeder Halter mehrere entlang einer Längsachse angeordnete Behälteraufnahmen, welche zwischen den beiden Enden ausgebildet sind. Die Behälteraufnahmen können beispielsweise Senkbohrungen mit kreisrundem Querschnitt sein. Andere Querschnitte sind jedoch auch möglich. Jede Behälteraufnahme kann mindestens eine seitliche Öffnung umfassen, welche sich von der jeweiligen Behälteraufnahme quer zur Längsachse seitlich nach aussen erstreckt. Die mindestens eine Öffnung kann ein Schlitz oder ein Fenster sein. Jede Behälteraufnahme kann zwei seitliche Öffnungen umfassen, welche bezüglich der Längsachse sich gegenüberliegend angeordnet sind und welche zusammen mit der Behälteraufnahme einen Durchgang im Halter bilden. Jeder Behälteraufnahme können demnach ein Schlitz und ein Fenster, zwei Schlitze oder zwei Fenster zugeordnet sein. Es kann bei jeder Behälteraufnahme, bzw. bei jedem Fenster des Halters eine Klemmlasche vorgesehen sein, welche durch das Fenster in die jeweilige Behälteraufnahme ragt, wodurch ein darin aufgenommener Behälter klemmbar darin haltbar ist. Auf der Seite des Halters, welche die Fenster umfasst, kann eine Laschenplatte am Halter angeordnet sein, welche alle Klemmlaschen umfasst. Alternativ können die Klemmlaschen gemeinsam einstückig mit dem Rest des Halters ausgebildet sein.In one embodiment, each holder comprises a plurality of container receptacles arranged along a longitudinal axis, which are formed between the two ends. The container receptacles can, for example, be countersunk holes with a circular cross-section. However, other cross-sections are also possible. Each container receptacle can comprise at least one lateral opening, which extends laterally outwards from the respective container receptacle transversely to the longitudinal axis. The at least one opening can be a slot or a window. Each container receptacle can comprise two lateral openings, which are arranged opposite one another with respect to the longitudinal axis and which, together with the container receptacle, form a passage in the holder. Each container receptacle can therefore be assigned a slot and a window, two slots or two windows. A clamping tab can be provided for each container receptacle, or for each window of the holder, which protrudes through the window into the respective container receptacle, whereby a container received therein can be held in a clamped manner. On the side of the holder which comprises the windows, a tab plate can be provided on the holder. which encompasses all clamping tabs. Alternatively, the clamping tabs can be formed integrally with the rest of the holder.
Die erwähnten Ausführungsformen des Mischapparats lassen sich in beliebiger Kombination einsetzen, sofern sie sich nicht widersprechen.The mentioned designs of the mixing apparatus can be used in any combination, provided they do not contradict each other.
Eine erfindungsgemässe Mischanlage umfasst einen Maschinenständer, an welchem ein erfindungsgemässer Mischapparat angeordnet ist.A mixing plant according to the invention comprises a machine stand on which a mixing apparatus according to the invention is arranged.
Die Mischanlage kann eine Arbeitsfläche umfassen, welche am Maschineständer angeordnet ist und wobei der Mischapparat an der Arbeitsfläche angeordnet ist.The mixing plant can comprise a work surface which is arranged on the machine stand and wherein the mixing apparatus is arranged on the work surface.
In einer Ausführungsform umfasst die Mischanlage eine Pipettier-Einheit, mit welcher im Mischapparat befindlichen Behältern Fluide zugeführt oder entnommen werden können.In one embodiment, the mixing system comprises a pipetting unit with which fluids can be added to or removed from containers located in the mixing apparatus.
In einer Ausführungsform umfasst die Pipettier-Einheit eine Transport-Einheit, an welcher Pipettenspitzen angeordnet sind, und mit welcher die Pipettenspitzen in der Horizontalen und/oder in der Vertikalen in einem Bereich über dem Maschinenständer, bzw. über der Arbeitsfläche bewegbar sind.In one embodiment, the pipetting unit comprises a transport unit on which pipette tips are arranged and with which the pipette tips can be moved horizontally and/or vertically in an area above the machine stand or above the work surface.
In einer Ausführungsform umfasst die Mischanlage eine Leseeinheit, mit welcher Markierungen von den vom Mischapparat aufzunehmenden Behältern lesbar sind. Die Markierungen sind aus der Gruppe auswählbar, welche 1D-Barcode, 2D-Barcode, RFID-Tag und dergleichen umfasst. Die Leseeinheit kann zudem Markierungen erkennen, welche auf den Haltern zur Aufnahme der Behälter angebracht sind. Mit der Leseeinheit ist ebenfalls erkennbar in welcher Position der Behälterhalter ein Behälter aufgenommen ist und welche Position leer ist. Es ist weiter erkennbar, ob alle in den Mischapparat eingeschobenen Halter für Behälter vollständig zwischen der Basisplatte und dem Rückhalter eingeschoben sind.In one embodiment, the mixing system comprises a reading unit with which markings on the containers to be received by the mixing apparatus can be read. The markings can be selected from the group comprising 1D barcode, 2D barcode, RFID tag and the like. The reading unit can also recognize markings which are attached to the holders for receiving the containers. With The reading unit also shows in which position the container holder has a container and which position is empty. It is also possible to see whether all the container holders inserted into the mixer are completely inserted between the base plate and the retainer.
Die erwähnten Ausführungsformen der Mischanlage lassen sich in beliebiger Kombination einsetzen, sofern sie sich nicht widersprechen.The above-mentioned designs of the mixing system can be used in any combination, provided they do not contradict each other.
Ein erfindungsgemässes Verfahren zum Betrieb eines Mischapparates oder einer Mischanlage, umfasst die Schritte:
- Bereitstellen eines erfindungsgemässen Mischapparates;
- Einführen eines Halters mit darin angeordneten Behältern in die Aufnahmen der Schwenkaufnahme; und
- Schwenken der Schwenkaufnahme um die Schwenkachse mit der Antriebseinheit.
- Providing a mixing apparatus according to the invention;
- Inserting a holder with containers arranged therein into the receptacles of the swivel mount; and
- Swiveling the swivel mount around the swivel axis with the drive unit.
Das Einführen kann ein einsetzen sein, beispielsweise wenn die Schwenkaufnahme Zylinderstifte umfasst und der Halter mit entsprechend komplementären Bohrungen versehen ist. Das Einführen kann auch ein einschieben, sein, beispielsweise wenn die Schwenkaufnahme Nutensteine umfasst und der Halter mit einer entsprechend komplementären Nut versehen ist.The insertion can be an insertion, for example if the swivel mount comprises cylindrical pins and the holder is provided with corresponding complementary holes. The insertion can also be a pushing in, for example if the swivel mount comprises sliding blocks and the holder is provided with a corresponding complementary groove.
In einer Ausführungsform umfasst das Verfahren die Schritte:
- Entfernen des Rückhalteelements vor dem Einführen des Halters; und
- Anbringen des Rückhalteelements nach dem Einführen des Halters.
- Removing the retaining element before inserting the holder; and
- Attaching the retaining element after inserting the holder.
Beispielsweise können Befestigungselemente entfernt werden, welche das Rückhalteelement in den entsprechenden Aufnahmen fixieren und das Rückhalteelement kann anschliessend abgehoben werden und unabhängig vom Mischapparat an einer anderen Stelle abgelegt werden. Alternativ kann das Rückhalteelement mittels eines Verschiebemechanismus vom Bereich über der Schwenkaufnahme linear weggeschoben werden. In einer weiteren Alternative kann das Rückhalteelement mittels eines Verdrehmechanismus vom Bereich über der Schwenkaufnahme in einer Ebene weggeschwenkt werden. Wenn das Rückhalteelement fix an der Schwenkaufnahme angeordnet ist, dann muss der Halter unter dem Rückhalteelement in die Schwenkaufnahme eingeschoben werden, beispielsweise entlang der Schwenkachse.For example, fastening elements that fix the retaining element in the corresponding receptacles can be removed and the retaining element can then be lifted off and placed in another location independently of the mixing device. Alternatively, the retaining element can be pushed linearly away from the area above the swivel mount using a sliding mechanism. In a further alternative, the retaining element can be pivoted away from the area above the swivel mount in a plane using a twisting mechanism. If the retaining element is fixed to the swivel mount, then the holder under the retaining element must be pushed into the swivel mount, for example along the swivel axis.
In einer Ausführungsform umfasst das Verfahren den Schritt:
- Einlesen von Markierungen der in einem Halter angeordneten Behältern mittels der Leseeinheit vor oder während dem Einführen des Halters. Werden die Markierungen währen dem Einführen des Halters eigelesen, so kann jeder aufgenommene Behälter einer bestimmten Position im Halter und dementsprechend in der Schwenkaufnahme, bzw. im Mischapparat zugeordnet werden. Soll das Einlesen während dem Einführen geschehen, so muss der Halter in die Schwenkaufnahme eingeschoben werden. Erfolgt das Einlesen vor dem Einführen, so ist darauf zu achten, dass der Halter richtig eingesetzt wird. Um ein falsches Einsetzen zu verhindern, können die ersten und zweiten Aufnahmen der Schwenkaufnahme und dementsprechend die ersten und zweiten Enden des Halters unterschiedlich ausgestaltet sein. Zusätzlich können Markierungen eingelesen werden, welche auf den Haltern aufgebracht sind.
- Reading in markings of the containers arranged in a holder using the reading unit before or during the insertion of the holder. If the markings are read during the insertion of the holder, each container picked up can be assigned to a specific position in the holder and accordingly in the swivel holder or in the mixing device. If the reading is to take place during insertion, the holder must be pushed into the swivel holder. If the reading takes place before insertion, it must be ensured that the holder is inserted correctly. To prevent incorrect insertion, the first and second recordings of the The swivel mount and the first and second ends of the holder can be designed differently. In addition, markings that are applied to the holders can be read.
In einer Ausführungsform umfasst das Verfahren die Schritte:
- Entnehmen von Fluiden aus den im Mischapparat befindlichen Behältern nach dem Schwenken der Schwenkaufnahme;
- Zuführen von Fluiden in die im Mischapparat befindlichen Behälter vor dem Schwenken der Schwenkaufnahme.
- Removing fluids from the containers in the mixing apparatus after swiveling the swivel holder;
- Supplying fluids into the containers in the mixing apparatus before swiveling the swivel holder.
Beispielsweise kann der Inhalt eines Mutter-Rohrs, welches beispielsweise Vollblut enthält, für sich oder mit zusätzlichen Substanzen gemischt werden. Nach dem Mischen kann ein Teil des Vollbluts vom Mutter-Rohr zu einem Tochter-Rohr um-pipettiert werden. Das Tochter-Rohr kann zuvor leer sein oder kann eine Substanz, wie beispielsweise ein Reagenz beinhalten. Anschliessend kann der Inhalt des Tochter-Rohrs nochmals gemischt werden. Nach dem Mischen kann der Halter mit den darin angeordneten Behältern aus dem Mischapparat entfernt werden und einem Analysegerät zugeführt werden. Für das Entnehmen und/oder Zuführen von Fluiden aus Behältern, welche durch einen Deckel verschlossen sind, welcher ein Septum umfasst, ist es nötig das Septum zu durchstechen, beispielsweise mit einer Pipettennadel.For example, the contents of a mother tube, which contains whole blood, for example, can be mixed on its own or with additional substances. After mixing, part of the whole blood can be pipetted from the mother tube to a daughter tube. The daughter tube can be empty beforehand or can contain a substance, such as a reagent. The contents of the daughter tube can then be mixed again. After mixing, the holder with the containers arranged in it can be removed from the mixing device and fed into an analysis device. To remove and/or add fluids from containers that are closed by a lid that includes a septum, it is necessary to pierce the septum, for example with a pipette needle.
Die erwähnten Ausführungsformen des Verfahrens lassen sich in beliebiger Kombination einsetzen, sofern sie sich nicht widersprechen.The embodiments of the method mentioned can be used in any combination, provided they do not contradict each other.
Ausführungsbeispiele der vorliegenden Erfindung werden nachstehend anhand von Figuren noch näher erläutert. Diese dienen lediglich zur Erläuterung und sind nicht einschränkend auszulegen. Es zeigen
-
Fig. 1 eine perspektivische Ansicht eines erfindungsgemässen Mischapparates; -
Fig. 2 der Mischapparat derFigur 1 ohne Antrieb, ohne Rückhalter und ohne Leseeinheit; -
Fig. 3A den Rückhalter derFigur 1 ; -
Fig. 3B eine alternative Ausführungsformen des Rückhalters derFigur 1 ; -
Fig. 3C eine Schnittansicht des Mischapparates derFigur 1 quer zur Achse, durch einen hohen und einen niedrigen Behälter; -
Fig. 4 eine perspektivische Ansicht einer zweiten Ausführungsformen einer Schwenkaufnahme mit einem alternativen Rückhalter; -
Fig. 5 eine perspektivische Unteransicht des Rückhalters derFigur 4 ; -
Fig. 6 einen Halter mit darin eingesetzten Behältern wie inder Figur 2 ; und -
Fig. 7 eine erfindungsgemässe Mischanlage.
-
Fig.1 a perspective view of a mixing apparatus according to the invention; -
Fig.2 the mixing apparatus of theFigure 1 without drive, without retainer and without reading unit; -
Fig. 3A the retainer of theFigure 1 ; -
Fig. 3B an alternative embodiment of the retainer of theFigure 1 ; -
Fig. 3C a sectional view of the mixing apparatus of theFigure 1 across the axis, through a high and a low container; -
Fig.4 a perspective view of a second embodiment of a pivot mount with an alternative retainer; -
Fig.5 a perspective bottom view of the retainer of theFigure 4 ; -
Fig.6 a holder with containers inserted into it as in theFigure 2 ; and -
Fig.7 a mixing plant according to the invention.
Die
Die
Die
Die
Die
Die
Die
Die
Die
Claims (18)
- A mixing apparatus (100), comprising:a drive unit (1) having a drive (10) and a shaft (11) which is pivotable about an essentially horizontally aligned pivot axis (A) and is operatively connected to the drive (10),a pivotable receptacle (2), which is arranged on the shaft (11),wherein the pivotable receptacle (2) comprises a base plate (20) and at least one retainer (4,400) spaced therefrom, wherein the pivotable receptacle (2) is configured in such a way that holders (3) for containers (7,70) can be inserted between the base plate (20) and the at least one retainer (4,400) in the direction of the pivot axis (A),wherein the at least one retainer (4;400) comprises at least one plate (41;401,42) having at least one throughhole (40;402), wherein the through-holes (40;402) are arranged such that, when the retainers (3) are inserted, they are aligned flush with the container receptacles (32) formed in the holders (3),characterized in that the at least one retainer (4) comprises a first plate (41) and a second plate (42), wherein the distance between the base plate (20) and the first plate (41) is greater than that between the base plate (20) and the second plate (42).
- The mixing apparatus (100) according to claim 1, comprising a control unit (12) with which the pivoting angle, the pivoting speed and the pivoting direction can be adjusted, wherein the pivotable receptacle (2) can be pivoted through any angle in both directions about the pivot axis (A).
- The mixing apparatus (100) according to one of the preceding claims, wherein on the side of the base plate (2) facing the at least one retainer (4,400), receptacles (200) are provided which are aligned in the direction of the pivot axis (A) and into which the holders (3) for containers (7) can be inserted.
- The mixing apparatus (100) according to one of the preceding claims, wherein the base plate (20) is connected to the at least one retainer (4,400) by the drive plate (21) .
- The mixing apparatus (100) according to claim 1, wherein the base plate (20) is connected to the at least one retainer (4,400) by the support element (22), wherein the support element (22) comprises a plate which is aligned essentially perpendicularly to the base plate (20) and the pivot axis (A), wherein the support element (22) comprises a central opening (221) and wherein the base plate (20) projects at least partially through the central opening (221) .
- The mixing apparatus (100) according to claim 1 or 5, wherein at least one connector (23) is provided which connects the drive plate (21) to the support element (22).
- The mixing apparatus (100) according to one of claims 1 or 4 to 6, wherein the drive plate (21) comprises at least one groove (210) for accommodating the at least one retainer (4,400).
- The mixing apparatus (100) according to one of claims 1 or 5 to 7, wherein the support element (22) comprises at least one fixation (222) for fixing the at least one retainer (4,400).
- The mixing apparatus (100) according to claim 1, wherein the inner dimensions of the through-holes (40;402) are smaller than the inner dimensions of the container receptacles (32) of the insertable holders (3).
- The mixing apparatus (100) according any one of claims 1 to 9, wherein at least one tab (43;404) is jointly formed integrally and essentially flush with the at least one plate (41;401,42).
- The mixing apparatus (100) according to one of claims 1 to 10, wherein at least one rib (44;403) is jointly formed integrally with the at least one plate (41;401,42), which extends along the pivot axis (A) over at least a portion of the at least one plate (41;401,42).
- The mixing apparatus (100) according to claim 11, wherein at least one tab (405) is jointly formed integrally with the at least one rib (403) and spaced parallel to the at least one plate (401).
- The mixing apparatus (100) according to one of the preceding claims, comprising at least one holder (3) for containers (7,70), which is inserted between the base plate (20) and the at least one retainer (4,400).
- A mixing system comprising:
a machine stand (8) on which a mixing apparatus (100) is arranged according to one of claims 1 to 13, comprising a pipetting unit (81) with which fluids can be added to or removed from containers (7,70) located in the mixing apparatus (100), wherein the pipetting unit (81) comprises a transport unit (810), on which pipette tips (811) are arranged, and with which the pipette tips (811) are movable in the horizontal and/or in the vertical in a region above the machine stand (8) or above the working surface (80). - The mixing system according to claim 14, comprising a reading unit (82) which is arranged on the machine stand (8) or on the connecting plate (6) of the mixing apparatus (100) and with which markings of the containers (7,70) to be accommodated in the mixing apparatus (100) and/or markings of the holders (3) to be accommodated in the mixing apparatus (100) can be read.
- A method for operating a mixing apparatus (100) or mixing system, comprising the steps of- providing a mixing apparatus (100) according to one of claims 1 to 13;- inserting a holder (3) with containers (7, 70) arranged therein between the base plate (20) and the at least one retainer (4,400) in the direction of the pivot axis (A); and- pivoting the pivotable receptacle (2) about the pivot axis (A) with the drive unit (1).
- The method according to claim 16, comprising the step of- reading in markings of a holder (3) and/or the containers (7,70) arranged in a holder (3) by means of the reading unit (82) before or during the insertion of the holder (3).
- The method according to claim 16 or 17, comprising at least one of the following steps of- removing fluids from the containers (7,70) located in the mixing apparatus (100) after pivoting the pivotable receptacle (2) by means of the pipetting unit (81);- feeding fluids into the containers (7,70) located in the mixing apparatus (100) before pivoting the pivotable receptacle (2) by means of the pipetting unit (81).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18185420.9A EP3599013A1 (en) | 2018-07-25 | 2018-07-25 | Mixing apparatus |
EP19742060.7A EP3826757B1 (en) | 2018-07-25 | 2019-07-24 | Mixing apparatus |
PCT/EP2019/069871 WO2020020923A1 (en) | 2018-07-25 | 2019-07-24 | Mixing apparatus, mixing system and method for mixing substances in closed containers |
Related Parent Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19742060.7A Division-Into EP3826757B1 (en) | 2018-07-25 | 2019-07-24 | Mixing apparatus |
EP19742060.7A Division EP3826757B1 (en) | 2018-07-25 | 2019-07-24 | Mixing apparatus |
Publications (2)
Publication Number | Publication Date |
---|---|
EP4218996A1 EP4218996A1 (en) | 2023-08-02 |
EP4218996B1 true EP4218996B1 (en) | 2024-07-31 |
Family
ID=63047178
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP21191494.0A Pending EP3932532A1 (en) | 2018-07-25 | 2018-07-25 | Mixing device, mixing system and method for mixing substances in closed containers |
EP18185420.9A Withdrawn EP3599013A1 (en) | 2018-07-25 | 2018-07-25 | Mixing apparatus |
EP23159223.9A Active EP4218996B1 (en) | 2018-07-25 | 2019-07-24 | Mixing apparatus, mixing system and method for mixing substances in closed containers |
EP19742060.7A Active EP3826757B1 (en) | 2018-07-25 | 2019-07-24 | Mixing apparatus |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP21191494.0A Pending EP3932532A1 (en) | 2018-07-25 | 2018-07-25 | Mixing device, mixing system and method for mixing substances in closed containers |
EP18185420.9A Withdrawn EP3599013A1 (en) | 2018-07-25 | 2018-07-25 | Mixing apparatus |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19742060.7A Active EP3826757B1 (en) | 2018-07-25 | 2019-07-24 | Mixing apparatus |
Country Status (4)
Country | Link |
---|---|
US (2) | US11969700B2 (en) |
EP (4) | EP3932532A1 (en) |
CN (2) | CN116550196A (en) |
WO (1) | WO2020020923A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10967341B2 (en) * | 2018-07-25 | 2021-04-06 | Tecan Trading Ag | Mixing device |
CN112121721A (en) * | 2020-09-27 | 2020-12-25 | 江苏乐士源新能源科技有限公司 | High-speed mixing device for processing lithium ion battery negative electrode material |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3226094A (en) * | 1963-08-01 | 1965-12-28 | Royal Alexandra Hosp Children | Warming and shaking apparatus |
FR2692358B1 (en) * | 1992-06-11 | 1995-08-04 | Abx Sa | DEVICE FOR TRANSFERRING, STIRRING AND COLLECTING SAMPLES OF BLOOD PRODUCTS IN TUBES GROUPED INTO CASSETTES, ESPECIALLY FOR HEMATOLOGICAL ANALYZERS. |
US5918979A (en) * | 1997-02-27 | 1999-07-06 | Scientific Industries Inc. | Combination mechanical rotator-rocker |
US6793893B2 (en) * | 1999-10-12 | 2004-09-21 | Crystal Spring Colony Farms Ltd. | Semen storage |
US6893613B2 (en) * | 2002-01-25 | 2005-05-17 | Bristol-Myers Squibb Company | Parallel chemistry reactor with interchangeable vessel carrying inserts |
US7121713B2 (en) * | 2004-02-27 | 2006-10-17 | United States Gypsum Company | Swinging agitator for a gypsum calcining apparatus and the like |
US8246919B2 (en) * | 2006-09-21 | 2012-08-21 | Abbott Laboratories | Specimen sample rack |
FR2907905B1 (en) * | 2006-10-30 | 2009-04-03 | C2 Diagnostics Sa | "APPARATUS AND METHOD FOR HANDLING TUBES, IN PARTICULAR AUTOMATIC BLOOD ANALYSIS APPARATUS" |
US8501115B2 (en) * | 2008-10-24 | 2013-08-06 | Statspin, Inc. | Modular system for performing laboratory protocols and associated methods |
US8028843B2 (en) * | 2009-05-15 | 2011-10-04 | Hamilton Company | Shift and scan test tube rack apparatus and method |
US9144801B2 (en) * | 2010-08-31 | 2015-09-29 | Abbott Laboratories | Sample tube racks having retention bars |
CN201891228U (en) * | 2010-09-30 | 2011-07-06 | 福建弘景木塑科技股份有限公司 | Combined type wall plate |
CN103250056B (en) * | 2010-11-12 | 2016-09-07 | 简.探针公司 | For following the tracks of the system and method for article during certain |
JP5678248B2 (en) * | 2010-12-21 | 2015-02-25 | メディカテック株式会社 | Test tube stirring device |
CN103084105A (en) * | 2011-11-07 | 2013-05-08 | 杨杰 | Rotary shaking table for test tubes |
DE102012013680A1 (en) * | 2012-07-11 | 2014-01-16 | Euroimmun Medizinische Labordiagnostika Ag | Device and method for incubation of patient samples |
CN103519831B (en) * | 2013-10-24 | 2015-07-22 | 杭州晟维东智能科技有限公司 | Blood collection equipment |
FR3025170B1 (en) * | 2014-08-28 | 2016-08-12 | Renault Sa | ASSEMBLY OF REINFORCING INSERTS BY A POLYMERIC MATERIAL, IN PARTICULAR FOR A FRONT OF A VEHICLE TECHNICAL FRAME, THIS ASSEMBLY BEING ENHANCED BY FIXING IT TO A STRUCTURAL ELEMENT |
US10401322B2 (en) * | 2014-12-17 | 2019-09-03 | Merck Ltd. | Biomolecule analyzer |
LU92703B1 (en) * | 2015-04-29 | 2016-10-31 | Stratec Biomedical Ag | Intelligent rack |
FR3043782B1 (en) | 2015-11-13 | 2017-12-08 | Horiba Abx Sas | STIRRING AND SAMPLING DEVICE FOR SAMPLE BIOLOGICAL LIQUIDS SUITABLE FOR SORTING |
CN105457542B (en) * | 2016-01-12 | 2018-07-10 | 冯丹 | Lift oscillator |
US9776188B1 (en) * | 2016-03-29 | 2017-10-03 | Heathrow Scientific Llc | Adjustable test tube holder |
CN206139043U (en) * | 2016-09-21 | 2017-05-03 | 成松音 | Coating stirrer with accuse temperature function |
CN107913626B (en) * | 2016-10-10 | 2021-05-14 | 深圳开立生物医疗科技股份有限公司 | Test tube row mixing device |
CN206274302U (en) * | 2016-12-23 | 2017-06-23 | 深圳市雷诺华科技实业有限公司 | Shake up structure and glycolated hemoglobin analysis |
JP6444437B2 (en) * | 2017-01-10 | 2018-12-26 | 富士夫 堀 | Container rotation device |
CN206701173U (en) * | 2017-05-16 | 2017-12-05 | 陈小丽 | A kind of medical test places processing frame with fluid sample |
CN107628285A (en) * | 2017-09-08 | 2018-01-26 | 安徽华瑞医药技术开发有限公司 | Homogeneous oscillation device is used in a kind of bottled powder medicine production |
CN107703266A (en) * | 2017-09-27 | 2018-02-16 | 龙里县逸轩生产力促进中心 | A kind of food inspection for being suitable for different length test tube test tube shakes equipment |
CN108144547B (en) * | 2018-03-16 | 2020-04-28 | 蓝天 | Medical science test tube shakes even device |
US10967341B2 (en) * | 2018-07-25 | 2021-04-06 | Tecan Trading Ag | Mixing device |
-
2018
- 2018-07-25 EP EP21191494.0A patent/EP3932532A1/en active Pending
- 2018-07-25 EP EP18185420.9A patent/EP3599013A1/en not_active Withdrawn
-
2019
- 2019-07-24 WO PCT/EP2019/069871 patent/WO2020020923A1/en active Application Filing
- 2019-07-24 EP EP23159223.9A patent/EP4218996B1/en active Active
- 2019-07-24 EP EP19742060.7A patent/EP3826757B1/en active Active
- 2019-07-24 CN CN202310636479.7A patent/CN116550196A/en active Pending
- 2019-07-24 US US17/261,325 patent/US11969700B2/en active Active
- 2019-07-24 CN CN201980048278.7A patent/CN112469496B/en active Active
-
2024
- 2024-03-13 US US18/603,768 patent/US20240252997A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP3826757A1 (en) | 2021-06-02 |
EP3826757B1 (en) | 2023-04-26 |
CN116550196A (en) | 2023-08-08 |
EP4218996A1 (en) | 2023-08-02 |
US11969700B2 (en) | 2024-04-30 |
EP3932532A1 (en) | 2022-01-05 |
US20210260541A1 (en) | 2021-08-26 |
WO2020020923A1 (en) | 2020-01-30 |
US20240252997A1 (en) | 2024-08-01 |
CN112469496A (en) | 2021-03-09 |
CN112469496B (en) | 2023-06-16 |
EP3599013A1 (en) | 2020-01-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP3478418B1 (en) | Metering head, metering device comprising a metering head, and method for metering by means of a metering head | |
DE69308493T2 (en) | SUPPORT FOR TEST TUBES | |
EP0871894B1 (en) | Modular reagent cartridge | |
EP0602485B1 (en) | Sample centrifuging device | |
EP2030684B1 (en) | Device for providing pipettable substances | |
EP2508259B1 (en) | Pipetting device | |
EP1705149B1 (en) | Device for automatic opening and closing of reaction vessels | |
EP3479129B1 (en) | Metering head, metering device comprising a metering head, and method for metering by means of a metering head | |
EP2207019B1 (en) | Weighed goods holder for a weighing machine | |
EP2408563B1 (en) | Positioning device for a sample carrier | |
DE3515824A1 (en) | METHOD AND DEVICE FOR REMOVING LIQUID FROM A CONTAINER | |
DE60037271T2 (en) | ANALYZER WITH A ROTATABLE FRAME STAND | |
EP4218996B1 (en) | Mixing apparatus, mixing system and method for mixing substances in closed containers | |
WO2008058979A1 (en) | Reagent container and reagent carousel | |
EP2781921A1 (en) | Closure system for reagent container mounting positions in an automatic analyzer | |
EP0272751A2 (en) | Assembling machine for a package | |
EP3080614B1 (en) | Sample-manipulating device | |
DE202018104287U1 (en) | Blender | |
EP3270167A1 (en) | Transport of liquid containers in an automatic analyzer | |
EP3666381B1 (en) | Laboratory device for automatic treatment of laboratory samples | |
EP2754492B1 (en) | A closure device for access port of a container for reagent vessels in an automated analyzer | |
DE29619444U1 (en) | Pipetting device | |
EP0022988A1 (en) | Holder for tubular vessels | |
EP3915737B1 (en) | Method for loading an empty cassette and for operating a robot, tool head for a robot and processing line | |
EP3590854B1 (en) | System consisting of a counter and a support and direct printing machine |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN PUBLISHED |
|
AC | Divisional application: reference to earlier application |
Ref document number: 3826757 Country of ref document: EP Kind code of ref document: P |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
17P | Request for examination filed |
Effective date: 20230919 |
|
RBV | Designated contracting states (corrected) |
Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: GRANT OF PATENT IS INTENDED |
|
INTG | Intention to grant announced |
Effective date: 20240315 |
|
P01 | Opt-out of the competence of the unified patent court (upc) registered |
Effective date: 20240327 |
|
GRAS | Grant fee paid |
Free format text: ORIGINAL CODE: EPIDOSNIGR3 |
|
GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE PATENT HAS BEEN GRANTED |
|
AC | Divisional application: reference to earlier application |
Ref document number: 3826757 Country of ref document: EP Kind code of ref document: P |
|
AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: EP Ref country code: GB Ref legal event code: FG4D Free format text: NOT ENGLISH |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R096 Ref document number: 502019011815 Country of ref document: DE |
|
REG | Reference to a national code |
Ref country code: IE Ref legal event code: FG4D Free format text: LANGUAGE OF EP DOCUMENT: GERMAN |