EP4171231A1 - Disinfecting, skin-tolerable care agent for application to the skin - Google Patents

Disinfecting, skin-tolerable care agent for application to the skin

Info

Publication number
EP4171231A1
EP4171231A1 EP21735699.7A EP21735699A EP4171231A1 EP 4171231 A1 EP4171231 A1 EP 4171231A1 EP 21735699 A EP21735699 A EP 21735699A EP 4171231 A1 EP4171231 A1 EP 4171231A1
Authority
EP
European Patent Office
Prior art keywords
skin
cream
disinfecting
agent
chlorine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21735699.7A
Other languages
German (de)
French (fr)
Inventor
Rainer Pommersheim
Denis Breuch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merlin Apotheke Ruth Gebhardt U Dr Frank Ullrich oHG
Tulichem GmbH
Original Assignee
Merlin Apotheke Ruth Gebhardt U Dr Frank Ullrich oHG
Tulichem GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merlin Apotheke Ruth Gebhardt U Dr Frank Ullrich oHG, Tulichem GmbH filed Critical Merlin Apotheke Ruth Gebhardt U Dr Frank Ullrich oHG
Publication of EP4171231A1 publication Critical patent/EP4171231A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N41/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
    • A01N41/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
    • A01N41/04—Sulfonic acids; Derivatives thereof
    • A01N41/06—Sulfonic acid amides
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/20—Elemental chlorine; Inorganic compounds releasing chlorine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/042—Gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29—Titanium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations

Definitions

  • the invention relates to a disinfecting, skin-friendly, caring agent for application to the skin and for treating it, comprising one or more water-soluble chlorine derivatives as disinfecting active ingredient, a cream based on such an agent and a dispenser, jar, tube or packaging with a disinfectant or a related cream or gel according to the teaching of the independent claims.
  • Products which can be applied to the skin and which have a disinfecting, germ-reducing effect when applied to the skin.
  • Well-known preparations are based on the active ingredients isopropanol, ethanol or other alcohols.
  • gels are known in which the alcohol has been thickened.
  • the alcohol In order to develop a sufficient disinfecting effect here, the alcohol must be present in a concentration of at least 70%. Such a concentration can easily be achieved with gels. A cream cannot be manufactured with regard to these concentrations.
  • a chloramine-containing wound treatment agent is previously known from DE 10 2006 043 245 A1.
  • a wound compress containing 10% chloramine is obtained by spraying with a chloramine-T solution.
  • the presented system can be primarily suitable for bleeding wounds with simultaneous disinfection by the aqueous chloramine solution for supply.
  • EP 1 955 591 A1 reference is made to a benzalkonium chloride as a disinfectant and an antimicrobial skin treatment agent in a cream base with regard to the agent for the care and antimicrobial treatment of the skin.
  • This cream has the aforementioned benzalkonium chloride as the only pharmaceutically active ingredient.
  • a related ointment is based on viscous to solid paraffin, wool wax and / or white vaseline.
  • the agent according to EP 1 955 591 A1 should also be suitable for caring disinfection of the skin, in particular for doctors or medical personnel.
  • the object of the invention to provide a further developed, disinfectant, skin-friendly, caring agent, in particular a cream, for application to the skin, which, in addition to good skin compatibility and a caring and greasy effect, also has a demonstrably sufficient disinfecting effect unfolded, whereby it is primarily not about a wound disinfection, but about the everyday use for hand disinfection and thus to interrupt possible chains of infection.
  • a cream is understood to be an oil-in-water emulsion or water-in-oil emulsion that makes ingredients applicable. Compared to ointments, creams have a lower viscosity, i.e. more liquid, and are well absorbed by the skin. Emulsifiers or emulsion stabilizers are often used in creams. In common parlance, creams are also referred to as non-medical, purely care products.
  • a disinfecting, skin-friendly, caring agent for application to the skin or for treating the skin according to the combination of features according to claim 1, a cream or gel according to claim 4 or a dispenser, a can, a tube or a packaging according to claim 8 solved.
  • the agent according to the invention does not rely on an alcohol as the disinfecting active ingredient, but on a chlorine derivative. Such an active ingredient is recommended and suitable as a disinfectant in appropriate concentrations when applied to the skin.
  • the chlorine derivatives used in the formulation according to the invention are readily soluble in water and can be incorporated very easily into the cream in the recommended concentrations.
  • Tests carried out with test persons who were carried out with the cream according to the invention demonstrate the germicidal effect with good skin tolerance at the same time.
  • the disinfecting, skin-friendly care agent is based on one or more water-soluble chlorine derivatives as the disinfecting agent.
  • the chlorine derivative (s) are incorporated into a base cream or gel matrix.
  • the cream or gel contains a mixture of substances to mask the odor of the otherwise olfactory perceptible chlorine component.
  • the means has at least one fragrance or a mixture of fragrances.
  • a defined amount of functional active ingredients can be added to the specified formulation.
  • This can be, for example, an active ingredient for moistening or for protection against harmful radiation, in particular ultraviolet radiation.
  • the cream according to the invention based on the agent explained is characterized in that the amount of the chlorine derivative used, in particular chloramine-T, is essentially up to 5% by weight, preferably and in particular up to 2% by weight.
  • the base cream contains at least glycerides, vaseline and stearates.
  • the gel matrix contains at least sodium polyacrylate or water.
  • the disinfecting component i.e. the chlorine derivatives
  • the chlorine derivatives is preferably chloramine-T, sodium hypochlorite or similar substances.
  • the proposed agent or the corresponding cream is free of alcohols with regard to the disinfectant active ingredient.
  • the skin is not degreased as is the case with conventional liquid disinfectants.
  • a dispenser, a can, a tube or similar packaging with the proposed agent or a corresponding cream for different applications, in particular for application to the human skin, is in accordance with the invention.
  • the base cream matrix used combines all of the ingredients required for skin care and ensures that the cream has a greasy and nourishing effect.
  • the disinfecting agent is based on water-soluble chlorine derivatives, which are recognized disinfectants and meet official requirements.
  • the substance mixture for odor marking is a mixture of dermatologically approved components with the aim of masking the chlorine odor released by the disinfecting agent.
  • Usable fragrances give the cream a pleasant smell. These can be essential oils or other fragrances or mixtures made from them. Urea, for example, can be used with the functional active ingredients to achieve an additional moisturizing effect. However, a means for absorbing ultraviolet radiation can also be used.
  • a commercially available product can be used in particular for the base cream.
  • Such a base cream includes the following exemplary ingredients:
  • Glycerol Monostearate 60 Cetyl Alcohol, Medium Chain Triglycerides, White Vaseline, Macrogol 20 Glycerol Monostearate, Propylene Glycol, and Purified Water.
  • Chlorine derivatives such as chloramine-T or sodium hypochlorite are used for the disinfecting agent.
  • concentration in the cream is 2% by weight. This is a harmless upper limit at which a sufficient disinfecting effect is demonstrably given.
  • compositions are exemplary:
  • Ingredients mixture B Hexyl salicylate, 3,7-dimethyloctan-3-ol, l- (l, 2,3,4,5,6,7,80ctahydro- 2,3,8,8tetramethyl-2naphthyl) ethan-l-one, 2H- Pyran-4-ol, tetrahydro-4-methyl-2 (2-methylpropyl) -, benzenepentanol, b-methyl-, benzenepropanol, .beta.,.
  • Essential oils such as rose oil, lavender oil or the like or mixtures of such essential oils are used as fragrances.
  • the functional active ingredients mentioned do not have to be part of the cream, but can improve its effect and ensure further applications.
  • a titanium dioxide can be added to the cream as a means of protection against ultraviolet radiation in order to ensure an appropriate sun protection factor.
  • a ready-to-sell cream as a disinfectant, skin-friendly and caring agent comprises at least the base cream and the disinfectant active ingredient in the form of water-soluble chlorine derivatives.
  • the cream according to the invention is bottled after processing and production.
  • a filling can be carried out here in a suitable dispenser, in a can, a tube or similar packaging.
  • the cream is applied by applying it to the skin and gently rubbing it in, which unfolds its disinfecting and, at the same time, nourishing effect.
  • the cream presented can either be used on its own or for subsequent skin care after using alcohol-based disinfecting products.
  • this is transparent or translucent.
  • the spheres which are encapsulated, create a special optical effect.
  • the beads are of a different color than the base cream or are particularly noticeable visually with regard to the transparent cream.
  • the beads which contain additional active ingredients, float within the gel or are distributed in the volume of the cream.
  • the beads with encapsulated additives incorporated therein are substantially 2 mm in diameter.

Abstract

The invention relates to a disinfecting, skin-tolerable care agent for application to the skin or for the treatment thereof, comprising one or more water-soluble chlorine derivatives as a disinfecting active substance, wherein the chlorine derivative(s) is/are incorporated in a base creme or gel matrix and additionally contain(s) a substance mixture for odor-masking the chlorine component.

Description

Desinfizierendes, hautverträgliches, pflegendes Mittel zum Aufträgen auf die Haut Disinfecting, skin-friendly, caring agent for application to the skin
Beschreibung description
Die Erfindung betrifft ein desinfizierendes, hautverträgliches, pflegendes Mittel zum Aufträgen auf die Haut und zur Behandlung dieser, aufweisend ein oder mehrere wasserlösliche Chlorderivate als desinfizierenden Wirkstoff, eine Creme auf der Basis eines solchen Mittels sowie einen Spender, Dose, Tube oder eine Verpackung mit einem desinfizierenden Mittel oder einer diesbezüglichen Creme oder einem Gel gemäß der Lehre der unabhängigen Ansprüche. The invention relates to a disinfecting, skin-friendly, caring agent for application to the skin and for treating it, comprising one or more water-soluble chlorine derivatives as disinfecting active ingredient, a cream based on such an agent and a dispenser, jar, tube or packaging with a disinfectant or a related cream or gel according to the teaching of the independent claims.
Es sind Produkte bekannt, die auf die Haut aufgetragen werden können und bei welchen durch den Auftrag auf die Haut eine desinfizierende, keimmindernde Wirkung resultiert. Bekannte Präparate basieren auf den Wirkstoffen Isopropanol, Ethanol oder anderen Alkoholen. Products are known which can be applied to the skin and which have a disinfecting, germ-reducing effect when applied to the skin. Well-known preparations are based on the active ingredients isopropanol, ethanol or other alcohols.
Neben flüssigen Produkten sind Gele bekannt, bei welchen der Alkohol eingedickt wurde. In addition to liquid products, gels are known in which the alcohol has been thickened.
Um hier eine ausreichende desinfizierende Wirkung zu entfalten, muss der Alkohol in einer Konzentration von mindestens 70 % vorliegen. Eine derartige Konzentration ist bei Gelen einfach realisierbar. Eine Creme lässt sich doch im Hinblick auf die diese Konzentrationen nicht fertigen. In order to develop a sufficient disinfecting effect here, the alcohol must be present in a concentration of at least 70%. Such a concentration can easily be achieved with gels. A cream cannot be manufactured with regard to these concentrations.
Bisher bekannte Cremes, enthaltend Alkohol zur Desinfektion sind im medizinischen Sinne sowie unter Hygieneaspekten daher nicht ausreichend und in ihrer Wirksamkeit beschränkt. Previously known creams containing alcohol for disinfection are therefore insufficient in the medical sense and under hygiene aspects and their effectiveness is limited.
Aus der DE 10 2006 043 245 Al ist ein chloraminhaltiges Wundbehandlungsmittel vorbekannt. A chloramine-containing wound treatment agent is previously known from DE 10 2006 043 245 A1.
Dort wird eine 10 % chloraminhaltige Wundkompresse durch Besprühen mit einer Chloramin-T-Lösung erhalten. Zusammen mit einer physikalisch beladenen Zeolith-Komponente und einem flüssigkeitsdurchlässigen Deckmaterial kann sich das vorgestellte System primär für blutende Wunden bei gleichzeitiger Desinfektion durch die wässrige Chloraminlösung zur Versorgung eignen. There a wound compress containing 10% chloramine is obtained by spraying with a chloramine-T solution. Together with one physically loaded zeolite component and a liquid-permeable cover material, the presented system can be primarily suitable for bleeding wounds with simultaneous disinfection by the aqueous chloramine solution for supply.
Bei der EP 1 955 591 Al wird hinsichtlich des Mittels zur Pflege und zur antimikrobiellen Behandlung der Haut auf ein Benzalkoniumchlorid als Desinfektionsmittel und antimikrobielles Hautbehandlungsmittel in einer Cremegrundlage verwiesen. Diese Creme verfügt als einzigen pharmazeutisch wirksamen Bestandteil über das erwähnte Benzalkoniumchlorid. Bei einer diesbezüglichen Salbe wird als Grundlage dickflüssiges bis festes Paraffin, Wollwachs und/oder Weißes Vaselin genutzt. Das Mittel nach EP 1 955 591 Al soll auch zur pflegenden Desinfektion der Haut, insbesondere für Ärzte oder medizinisches Personal geeignet sein. In EP 1 955 591 A1, reference is made to a benzalkonium chloride as a disinfectant and an antimicrobial skin treatment agent in a cream base with regard to the agent for the care and antimicrobial treatment of the skin. This cream has the aforementioned benzalkonium chloride as the only pharmaceutically active ingredient. A related ointment is based on viscous to solid paraffin, wool wax and / or white vaseline. The agent according to EP 1 955 591 A1 should also be suitable for caring disinfection of the skin, in particular for doctors or medical personnel.
Aus dem Vorgenannten ist es Aufgabe der Erfindung, ein weiterentwickeltes, desinfizierendes, hautverträgliches, pflegendes Mittel, insbesondere eine Creme, zum Aufträgen auf die Haut anzugeben, welches bzw. welche neben einer guten Hautverträglichkeit und pflegenden sowie fettenden Wirkung zusätzlich eine nachweislich ausreichende, desinfizierende Wirkung entfaltet, wobei es primär nicht um eine Wunddesinfektion geht, sondern um den alltäglichen Gebrauch zur Handdesinfektion und damit zur Unterbrechung von möglichen Infektionsketten. From the above, it is the object of the invention to provide a further developed, disinfectant, skin-friendly, caring agent, in particular a cream, for application to the skin, which, in addition to good skin compatibility and a caring and greasy effect, also has a demonstrably sufficient disinfecting effect unfolded, whereby it is primarily not about a wound disinfection, but about the everyday use for hand disinfection and thus to interrupt possible chains of infection.
Medizinisch betrachtet versteht man unter einer Creme ein Öl-in- Wasseremulsion oder Wasser-in-Ölemulsion, die Inhaltsstoffe applikationsfähig macht. Cremes sind relativ zu Salben niedrigviskoser, das heißt flüssiger, und ziehen gut in die Haut ein. Bei Cremes finden häufig Emulgatoren oder Emulsionsstabilisatoren Anwendung. Im allgemeinen Sprachgebrauch werden Cremes auch als nicht-medizinische, rein pflegende Produkte bezeichnet. From a medical point of view, a cream is understood to be an oil-in-water emulsion or water-in-oil emulsion that makes ingredients applicable. Compared to ointments, creams have a lower viscosity, i.e. more liquid, and are well absorbed by the skin. Emulsifiers or emulsion stabilizers are often used in creams. In common parlance, creams are also referred to as non-medical, purely care products.
Gemäß der geschilderten Aufgabenstellung wird diese durch ein desinfizierendes, hautverträgliches, pflegendes Mittel zum Aufträgen auf die Haut oder zur Behandlung der Haut gemäß der Merkmalskombination nach Anspruch 1, einer Creme oder einem Gel nach Anspruch 4 bzw. einem Spender, einer Dose, einer Tube oder einer Verpackung gemäß Anspruch 8 gelöst. Im Unterschied zu bekannten Lösungen setzt das erfindungsgemäße Mittel nicht auf einen Alkohol als desinfizierenden Wirkstoff, sondern auf ein Chlorderivat. Ein solcher Wirkstoff ist in entsprechenden Konzentrationen beim Aufträgen auf die Haut als Desinfektionsmittel empfohlen und geeignet. According to the task described, this is achieved by a disinfecting, skin-friendly, caring agent for application to the skin or for treating the skin according to the combination of features according to claim 1, a cream or gel according to claim 4 or a dispenser, a can, a tube or a packaging according to claim 8 solved. In contrast to known solutions, the agent according to the invention does not rely on an alcohol as the disinfecting active ingredient, but on a chlorine derivative. Such an active ingredient is recommended and suitable as a disinfectant in appropriate concentrations when applied to the skin.
Die bei der erfindungsgemäßen Formulierung eingesetzten Chlorderivate sind gut wasserlöslich und können in den empfohlenen Konzentrationen sehr gut in die Creme eingearbeitet werden. The chlorine derivatives used in the formulation according to the invention are readily soluble in water and can be incorporated very easily into the cream in the recommended concentrations.
Durchgeführte Tests mit Probanden, die mit der erfindungsgemäßen Creme durchgeführt wurden, belegen die keimtötende Wirkung bei gleichzeitiger guter Hautverträglichkeit. Tests carried out with test persons who were carried out with the cream according to the invention demonstrate the germicidal effect with good skin tolerance at the same time.
Es geht das desinfizierende, hautverträgliche pflegende Mittel demnach von einem oder mehreren wasserlöslichen Chlorderivaten als desinfizierenden Wirkstoff aus. The disinfecting, skin-friendly care agent is based on one or more water-soluble chlorine derivatives as the disinfecting agent.
Der oder die Chlorderivate werden in eine Basiscreme oder Gel-Matrix eingebunden. The chlorine derivative (s) are incorporated into a base cream or gel matrix.
Zusätzlich enthält die Creme bzw. das Gel ein Stoffgemisch zur Geruchsmaskierung der ansonsten olfaktorisch wahrnehmbaren Chlorkomponente. In addition, the cream or gel contains a mixture of substances to mask the odor of the otherwise olfactory perceptible chlorine component.
Ausgestaltend weist das Mittel mindestens einen Duftstoff oder ein Duftstoffgemisch auf. In an embodiment, the means has at least one fragrance or a mixture of fragrances.
In Weiterbildung der Erfindung kann der vorgegebenen Formulierung eine definierte Menge funktionaler Wirkstoffe zugegeben werden. Hier kann es sich beispielsweise um einen Wirkstoff zur Befeuchtung oder zum Schutz vor schädigender Strahlung, insbesondere ultravioletter Strahlung, handeln. In a further development of the invention, a defined amount of functional active ingredients can be added to the specified formulation. This can be, for example, an active ingredient for moistening or for protection against harmful radiation, in particular ultraviolet radiation.
Die erfindungsgemäße Creme auf der Basis des erläuterten Mittels ist dadurch gekennzeichnet, dass die Menge des eingesetzten Chlorderivates, insbesondere Chloramin-T, bei im Wesentlichen bis zu 5 Gew.-%, bevorzugt und insbesondere bis zu 2 Gew.-% liegt. Die Basiscreme enthält mindestens Glyceride, Vaselin und Stearate. Die Gel-Matrix enthält mindestens Natriumpolyacrylat oder Wasser. The cream according to the invention based on the agent explained is characterized in that the amount of the chlorine derivative used, in particular chloramine-T, is essentially up to 5% by weight, preferably and in particular up to 2% by weight. The base cream contains at least glycerides, vaseline and stearates. The gel matrix contains at least sodium polyacrylate or water.
Bei dem desinfizierenden Bestandteil, das heißt den Chlorderivaten, handelt es sich, wie bereits erwähnt, bevorzugt um Chloramin-T, Natriumhypochlorit oder ähnliche Stoffe. As already mentioned, the disinfecting component, i.e. the chlorine derivatives, is preferably chloramine-T, sodium hypochlorite or similar substances.
Das vorgeschlagene Mittel bzw. die entsprechende Creme ist hinsichtlich des desinfizierenden Wirkstoffes frei von Alkoholen. Eine Entfettung der Haut wie bei üblichen flüssigen Mitteln zur Desinfektion findet nicht statt. The proposed agent or the corresponding cream is free of alcohols with regard to the disinfectant active ingredient. The skin is not degreased as is the case with conventional liquid disinfectants.
Erfindungsgemäß ist darüber hinaus ein Spender, eine Dose, eine Tube oder dergleichen Verpackung mit dem vorgeschlagenen Mittel oder einer entsprechenden Creme für unterschiedliche Anwendungen, insbesondere zum Aufträgen auf die menschliche Haut. In addition, a dispenser, a can, a tube or similar packaging with the proposed agent or a corresponding cream for different applications, in particular for application to the human skin, is in accordance with the invention.
Die Erfindung soll nachstehend anhand eines Ausführungsbeispieles näher erläutert werden. The invention is to be explained in more detail below using an exemplary embodiment.
Die eingesetzte Basiscreme-Matrix vereinigt alle zur Hautpflege nötigenden Inhaltsstoffe und sichert die fettende und gleichzeitig pflegende Wirkung der Creme. The base cream matrix used combines all of the ingredients required for skin care and ensures that the cream has a greasy and nourishing effect.
Der desinfizierende Wirkstoff basiert auf wasserlöslichen Chlorderivaten, welche anerkannte Desinfektionsmittel sind und die behördlichen Vorgaben erfüllen. The disinfecting agent is based on water-soluble chlorine derivatives, which are recognized disinfectants and meet official requirements.
Bei dem Stoffgemisch zur Geruchsmarkierung handelt es sich um ein Gemisch von dermatologisch zugelassenen Komponenten mit dem Ziel, den vom desinfizierenden Wirkstoff freigesetzten Chlorgeruch zu überdecken. The substance mixture for odor marking is a mixture of dermatologically approved components with the aim of masking the chlorine odor released by the disinfecting agent.
Einsetzbare Duftstoffe geben der Creme einen angenehmen Geruch. Hier kann es sich um ätherische Öle oder andere Riechstoffe oder daraus hergestellte Gemische handeln. Bei den funktionalen Wirkstoffen kann zum Beispiel Harnstoff Verwendung finden, um eine zusätzliche feuchtende Wirkung zu erzielen. Ebenso ist aber auch ein Mittel zur Absorption ultravioletter Strahlung einsetzbar. Usable fragrances give the cream a pleasant smell. These can be essential oils or other fragrances or mixtures made from them. Urea, for example, can be used with the functional active ingredients to achieve an additional moisturizing effect. However, a means for absorbing ultraviolet radiation can also be used.
Insbesondere für die Basiscreme kann ein handelsübliches Produkt Anwendung finden. A commercially available product can be used in particular for the base cream.
Eine solche Basiscreme umfasst folgende beispielhafte Inhaltstoffe: Such a base cream includes the following exemplary ingredients:
Glycerolmonostearat 60, Cetylalkohol, Mittelkettige Triglyceride, Weißes Vaselin, Macrogol-20-glycerolmonostearat, Propylenglycol und gereinigtes Wasser. Glycerol Monostearate 60, Cetyl Alcohol, Medium Chain Triglycerides, White Vaseline, Macrogol 20 Glycerol Monostearate, Propylene Glycol, and Purified Water.
Für den desinfizierenden Wirkstoff werden Chlorderivate genutzt, wie beispielsweise Chloramin-T oder Natriumhypochlorit. Insbesondere für Chloramin-T beträgt die Konzentration in der Creme 2 Gew.-%. Hier handelt es sich um eine unbedenkliche Obergrenze, bei welcher eine ausreichende desinfizierende Wirkung nachweislich gegeben ist. Chlorine derivatives such as chloramine-T or sodium hypochlorite are used for the disinfecting agent. For chloramine-T in particular, the concentration in the cream is 2% by weight. This is a harmless upper limit at which a sufficient disinfecting effect is demonstrably given.
Bei dem Stoffgemisch zur Geruchsmarkierung kann auf kommerziell erhältliche Produkte zurückgegriffen werden. Commercially available products can be used for the substance mixture for odor marking.
Beispielhaft sind folgende Zusammensetzungen: The following compositions are exemplary:
Inhaltsstoffe Gemisch A: Ingredients mixture A:
2,6-Dimethyloct-7-en-2ol, 3,7-Dimethyloctan-3-ol, l-(l,2,3,4,5,6,7,80ctahydro- 2,3,8,8tetramethyl-2naphthyl)ethan-l-one, Benzenepentanol, bmethyl- ,Isopentyl salicylate , 3-(p-Ethylphenyl)-2,2dimethylpropionaldehyde, 3,7-Dimethyloctan-3-yl acetate, Benzenepropanol, .beta.,.beta.,3-trimethyl-, 2-Phenylethanol, Anisaldehyde, (E)-4-(2,6,6-Trimethyll-cyclohexen-l-yl)-3buten-2-one, Oxacyclohexadecen-2-one, Piperonal, l,4-Dioxacycloheptadecane5,17-dione, Pentadecan-15-olide, Hexyl acetate, 3-(o-Ethylphenyl)-2,2dimethylpropionaldehyde, l-Methyl-4-(4methylpentyl)cyclohex3- ene-l-carbaldehyde 1; 2,6-dimethyloct-7-en-2ol, 3,7-dimethyloctan-3-ol, 1- (1,2,3,4,5,6,7,80ctahydro-2,3,8,8tetramethyl-2naphthyl ) ethan-l-one, benzenepentanol, bmethyl-, isopentyl salicylate, 3- (p-ethylphenyl) -2,2dimethylpropionaldehyde, 3,7-dimethyloctan-3-yl acetate, benzenepropanol, .beta.,. beta., 3- trimethyl-, 2-phenylethanol, anisaldehydes, (E) -4- (2,6,6-trimethyll-cyclohexen-l-yl) -3buten-2-ones, oxacyclohexadecen-2-ones, piperonal, 1,4-dioxacycloheptadecane5 , 17-dione, pentadecan-15-olide, hexyl acetate, 3- (o-ethylphenyl) -2,2dimethylpropionaldehyde, l-methyl-4- (4methylpentyl) cyclohex3-ene-l-carbaldehydes 1;
Inhaltsstoffe Gemisch B: Hexyl salicylate, 3,7-Dimethyloctan-3-ol , l-(l,2,3,4,5,6,7,80ctahydro- 2,3,8,8tetramethyl-2naphthyl)ethan-l-one , 2H-Pyran-4-ol, tetrahydro-4-methyl-2(2- methylpropyl)- , Benzenepentanol, bmethyl- ,Benzenepropanol, .beta.,.beta.,3- trimethyl-, Pentadecan-15-olide, 2,6-Dimethyloct-7-en-2ol, a-Methyl-l,3benzodioxole- 5propionaldehyde, 4-(4-Methyl-3pentenyl)cyclohex-3ene-l-carbaldehyde, (E)- Anethole, 2-Ethyl-4-(2,2,3trimethyl-3-cyclopentenl-yl)-2-buten-l-ol, 1,2,3,5,6,7- Hexahydro-l,l,2,3,3-pentamethyl-4H-inden-4-one, 3-(p-Ethylphenyl)- 2,2dimethylpropionaldehyde, MUGETANOL, Piperonal, Oxacyclohexadecen-2-one, 4- Methyl-3-decen-5-ol, 3-(o-Ethylphenyl)-2,2dimethylpropionaldehyde, Allyl cyclohexyloxy)acetate, Methyl 2,4-dihydroxy-3,6-dimethylbenzoate, 2,6-Dimethylhept- 5-enal, Octahydro-7-methyl-l,4methanonaphthalen6(2H)-one, cis-Hex-3-en-l-yl methyl carbonate Ingredients mixture B: Hexyl salicylate, 3,7-dimethyloctan-3-ol, l- (l, 2,3,4,5,6,7,80ctahydro- 2,3,8,8tetramethyl-2naphthyl) ethan-l-one, 2H- Pyran-4-ol, tetrahydro-4-methyl-2 (2-methylpropyl) -, benzenepentanol, b-methyl-, benzenepropanol, .beta.,. Beta., 3-trimethyl-, pentadecan-15-olide, 2,6- Dimethyloct-7-en-2ol, a-methyl-1,3benzodioxole- 5propionaldehyde, 4- (4-methyl-3pentenyl) cyclohex-3ene-l-carbaldehyde, (E) - anethole, 2-ethyl-4- (2, 2,3-trimethyl-3-cyclopentenl-yl) -2-buten-1-ol, 1,2,3,5,6,7-hexahydro-1,1,2,3,3-pentamethyl-4H-indene-4 -one, 3- (p-ethylphenyl) -2,2dimethylpropionaldehyde, MUGETANOL, piperonal, oxacyclohexadecen-2-one, 4-methyl-3-decen-5-ol, 3- (o-ethylphenyl) -2,2dimethylpropionaldehyde, allyl cyclohexyloxy) acetate, methyl 2,4-dihydroxy-3,6-dimethylbenzoate, 2,6-dimethylhept-5-enal, octahydro-7-methyl-1,4-methanonaphthalen6 (2H) -one, cis-hex-3-en- l-yl methyl carbonate
Als Duftstoffe kommen ätherische Öle, wie Rosenöl, Lavendelöl oder ähnliches bzw. Gemische aus solchen ätherischen Ölen zum Einsatz. Essential oils such as rose oil, lavender oil or the like or mixtures of such essential oils are used as fragrances.
Die erwähnten funktionalen Wirkstoffe müssen nicht Bestandteil der Creme sein, können jedoch deren Wirkung verbessern und für weitere Applikationen sorgen. The functional active ingredients mentioned do not have to be part of the cream, but can improve its effect and ensure further applications.
Als Mittel zum Schutz vor ultravioletter Strahlung kann der Creme ein Titandioxid beigegeben werden, um einen entsprechenden Lichtschutzfaktor sicherzustellen. A titanium dioxide can be added to the cream as a means of protection against ultraviolet radiation in order to ensure an appropriate sun protection factor.
Eine verkaufsfertige Creme als desinfizierendes, hautverträgliches und pflegendes Mittel umfasst mindestens die Basiscreme und den desinfizierenden Wirkstoff in Form wasserlöslicher Chlorderivate. A ready-to-sell cream as a disinfectant, skin-friendly and caring agent comprises at least the base cream and the disinfectant active ingredient in the form of water-soluble chlorine derivatives.
Durch die Zugabe des Stoffgemisches zur Geruchsmarkierung wird die Anwendung deutlich besser akzeptiert, da der unangenehme Chlorgeruch des oder der eingesetzten Chlorderivate einer Kapselung unterliegt. By adding the mixture of substances to the odor marking, the application is much better accepted, since the unpleasant chlorine odor of the chlorine derivative (s) used is subject to encapsulation.
Die erfindungsgemäße Creme wird nach Aufbereitung und Herstellung abgefüllt. Ein Abfüllen kann hier in einen geeigneten Spender, in eine Dose, eine Tube oder dergleichen Verpackung vorgenommen werden. Die Anwendung der Creme erfolgt durch Aufträgen auf die Haut und leichtes Einreiben, wodurch sich die desinfizierende und gleichzeitig pflegende Wirkung entfaltet. The cream according to the invention is bottled after processing and production. A filling can be carried out here in a suitable dispenser, in a can, a tube or similar packaging. The cream is applied by applying it to the skin and gently rubbing it in, which unfolds its disinfecting and, at the same time, nourishing effect.
Die vorgestellte Creme kann entweder allein oder zur nachträglichen Pflege der Haut bei vorheriger Verwendung desinfizierender Produkte auf Alkoholbasis eingesetzt werden. The cream presented can either be used on its own or for subsequent skin care after using alcohol-based disinfecting products.
Bei der erfindungsgemäßen Ausführungsform als Gel ist dieses im Unterschied zur vorgestellten Creme durchsichtig oder durchscheinend. In the embodiment according to the invention as a gel, in contrast to the cream presented, this is transparent or translucent.
Sowohl der Creme als auch dem erfindungsgemäßen Gel können weitere Stoffe in verkapselter Form beigefügt werden. Further substances can be added in encapsulated form to both the cream and the gel according to the invention.
Die in verkapselter Form ausgebildeten Kügelchen erzeugen einen besonderen optischen Effekt. Insbesondere sind die Kügelchen andersfarbig als die Basis-Creme bzw. fallen optisch bezüglich der durchsichtigen Creme besonders auf. Die Kügelchen, welche zusätzliche Wirkstoffe enthalten, schweben innerhalb des Gels bzw. sind im Volumen der Creme verteilt. In einem Beispiel haben die Kügelchen mit hierin aufgenommenen, verkapselten Zusatzstoffen einen Durchmesser von im Wesentlichen 2 mm. The spheres, which are encapsulated, create a special optical effect. In particular, the beads are of a different color than the base cream or are particularly noticeable visually with regard to the transparent cream. The beads, which contain additional active ingredients, float within the gel or are distributed in the volume of the cream. In one example, the beads with encapsulated additives incorporated therein are substantially 2 mm in diameter.

Claims

Ansprüche Expectations
1. Desinfizierendes, hautverträgliches, pflegendes Mittel zum Aufträgen auf die Haut oder zur Behandlung dieser, aufweisend ein oder mehrere wasserlösliche Chlorderivate als desinfizierenden Wirkstoff, dadurch gekennzeichnet, dass der oder die Chlorderivate in eine Basiscreme- oder Gel-Matrix eingebunden sind und zusätzlich enthaltend ein Stoffgemisch zur Geruchsmaskierung der Chlorkomponente. 1. Disinfecting, skin-friendly, caring agent for application to the skin or for treating it, comprising one or more water-soluble chlorine derivatives as disinfecting active ingredient, characterized in that the chlorine derivative (s) are incorporated into a base cream or gel matrix and additionally contain one Mixture of substances to mask the odor of the chlorine component.
2. Desinfizierendes, hautverträgliches, pflegendes Mittel nach Anspruch 1, dadurch gekennzeichnet, dass dieses mindestens einen Duftstoff oder ein Duftstoffgemisch enthält. 2. Disinfecting, skin-friendly, care agent according to claim 1, characterized in that it contains at least one fragrance or a mixture of fragrances.
3. Desinfizierendes, hautverträgliches, pflegendes Mittel nach Anspruch 1 oder 2, dadurch gekennzeichnet, dass dieses in vorgegebener Formulierung funktionale Wirkstoffe, beispielsweise zur Befeuchtung oder zum Schutz vor schädigender Strahlung aufweist. 3. Disinfecting, skin-friendly, caring agent according to claim 1 or 2, characterized in that it has functional active ingredients in a predetermined formulation, for example for moistening or for protection against harmful radiation.
4. Creme oder Gel auf der Basis eines Mittels nach einem der Ansprüche 1 bis4. Cream or gel based on an agent according to any one of claims 1 to
3, dadurch gekennzeichnet, dass die Menge der Chlorderivate bei im Wesentlichen bis zu 5 Gew.-%, insbesondere bis zu 2 Gew.-% liegt. 3, characterized in that the amount of chlorine derivatives is essentially up to 5% by weight, in particular up to 2% by weight.
5. Creme auf der Basis eines Mittels nach einem der Ansprüche 1 bis 3, dadurch gekennzeichnet, dass die Basiscreme mindestens Glyceride, Vaseline und Stearate und die Gel-Matrix mindestens Natriumpolyacrylat und Wasser enthält. 5. Cream based on an agent according to one of claims 1 to 3, characterized in that the base cream contains at least glycerides, petrolatum and stearate and the gel matrix contains at least sodium polyacrylate and water.
6. Mittel oder Creme nach einem der vorangegangenen Ansprüche, dadurch gekennzeichnet, dass als desinfizierender Bestandteil Chloramin-T, Natriumhypochlorid oder ein ähnliches Chlorderivat enthalten ist. 6. Agent or cream according to one of the preceding claims, characterized in that it contains chloramine-T, sodium hypochlorite or a similar chlorine derivative as the disinfecting component.
7. Mittel oder Creme nach einem der vorangegangenen Ansprüche, dadurch gekennzeichnet, dass hinsichtlich des desinfizierenden Wirkstoffes dieser frei von Alkoholen ist. 7. Agent or cream according to one of the preceding claims, characterized in that, with regard to the disinfecting agent, it is free from alcohols.
8. Spender, Dose, Tube oder Verpackung mit einem Mittel oder einer Creme nach einem oder mehreren der vorangegangenen Ansprüche. 8. Dispenser, jar, tube or packaging with an agent or a cream according to one or more of the preceding claims.
EP21735699.7A 2020-06-30 2021-06-24 Disinfecting, skin-tolerable care agent for application to the skin Pending EP4171231A1 (en)

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DE202020104277.7U DE202020104277U1 (en) 2020-06-30 2020-07-24 Disinfectant, skin-friendly, caring agent for application to the skin
PCT/EP2021/067357 WO2022002752A1 (en) 2020-06-30 2021-06-24 Disinfecting, skin-tolerable care agent for application to the skin

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FR2223049A1 (en) * 1973-03-30 1974-10-25 Conditionnement Cosmetologie N Halogenate antibacterial compns. - potentiated with alkali metal salts or capric, caproic and caprylic acids
DE19934585A1 (en) * 1999-07-23 2001-01-25 Rapp Horst Treatment of dermatological disorders, e.g. pruritus, herpes simplex infection, psoriasis or acne, using tosyl chloramide salt, e.g. in ointment or gel base
RU2235535C2 (en) * 2001-06-18 2004-09-10 Набокин Игорь Иванович Preparation for treating local purulent-inflammatory processes of skin and mucous membranes
DE102006043245A1 (en) 2006-09-11 2008-03-27 Dunzendorfer, Udo, Priv.-Doz. Dr.med. Wound treating device with disinfectant and coagulant effects, for use in hemostatic materials such as dressings, contains chloramine-zeolite double layer system
DE102007002073A1 (en) 2007-01-09 2008-07-10 Matthias Habenicht Medium for use during care and antimicrobial treatment of skin, for topical dermatological application, and for therapeutic skin and sore treatment, comprises benzalkonium chloride, which is basically exclusive pharmaceutically active
EP3446693B1 (en) * 2015-02-19 2020-11-11 Hiantis S.r.l. Pharmaceutical compositions and formulations comprising aluminium acetate for topical application with astringent and antimicrobial effect
CN109418289A (en) * 2017-09-05 2019-03-05 上海利康消毒高科技有限公司 A kind of sodium hypochlorite gel and preparation method thereof

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