DE1617633A1 - Lotion for hair care, to prevent hair loss as well as for hair regeneration and pigmentation - Google Patents

Description

η »ΜΛΐτ | ίΒΜ 8 MÖNCHEN 23, May 12th, 1970

Dr. ERNST STURM leopoldstrasse 20 / ιν

Deutsche Bank AG. Munich Account No. 21/34! 2O 1 R 1 7 R ^ ίΓΓΪΙΪ? ^St.

Postal check account: Munich 91707 ID I / DJO phone 396451

Telegraph address: Isarpatent,

Ministerul Industry! Alimentare, Bucharest / Romania

Lotion for hair care, to prevent hair loss and for hair regeneration and pigmentation.

The care of the hair for cosmetic purposes, for prevention of hair loss, for its regeneration and possibly for its repigmentation has always preoccupied researchers. Various theories have attempted the cause of hair loss in cases of baldness, hair loss, alopecia areata or the like · to be explained by the fact that these phenomena of the Seborrhea, the high blood pressure in the scalp tissue that causes attributed to poor blood supply, certain nutritional diseases, or endocrine or nervous disorders

A variety of methods have been used to combat these symptoms applied · Some of these increase the blood supply through irradiation and hassagen · Use other methods undergo external application or local injection of preparations containing a stimulant tonic, as well as bactericidal

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chemical substances such as salicylic acid, resorcinol, Alcohols, sulfamides, acetylcholine, choline, betaine, pantothenic acid Oodglo, contain · Other methods try cell swapping by means of vitamin F or vitamins of the B complex, hormones of various origins, cholesterol, lecithin or keratin preparations to influence · sulfur, thallium or mercury salts were as a result of their disinfecting or healing properties suggested · Finally, cortisone and A, C, T.H. (idenocorticotrophormon) known due to the fact that these compounds stop the loss of hair and its Cause regeneration, but this effect only during the stops for other purposes and some Weeks after stopping treatment disappears.

The use of procaine to treat the signs of aging and other trophic disorders has grown in scale in recent years. After that which took place for a few months Treatment with procaine will stimulate hair growth and reduce the tendency to repigmentation. Haares observes · This observation led to the idea that the local application of the procaine takes place in a general way would intensify and accelerate the effect achieved

Ss has now been found - this also represents the subject of the present invention - that the mixing of procaine, benzoic acid and ascorbic acid with substances »in general be used for hair care, or the use of the above-mentioned compounds alone a deep · and

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has a strong effect on hair strength and hair growth, provided that these compounds are applied to the scalp in a suitable manner. The substances mentioned are used in the following amounts: Procaine 0.5 to 5% (preferably 1 to 3% ) , benzoic acid and ascorbic acid 0.1 to 0.5 $> (preferably 0.10 to 0.15 # ■), in aqueous solution or in organic solvents, or in emulsions or mixtures that are used after shaking; If necessary, surface-active agents, wetting agents, emulsifiers and solvents for hair greasiness can also be added · It is also possible to add preservatives, stabilizers and fragrances ·

The lotions obtained in this way are under simultaneous light massage applied to the scalp at certain intervals

The active ingredients of the lotion have the following topical effects:.

Procaine is a major vasodilation agent, which causes a more active blood circulation in the scalp · It also has an antiallergic and tranquilizing effect · If it is partially absorbed, a well-known general eutrophic effect is achieved · Its vasodilation and TrancLuillizer effects has an effect on the development of the hair follicle

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The local effect obtained by applying the Proeain-containing Lotion is of higher intensity than the effect achieved by general treatment because the former is accelerated and intensified by the simultaneous application of the two treatments,

Benzoic acid is used for its antiseptic, germicidal and preservative properties

Ascorbic acid is added because of its vitamin effect, which increases the resistance of the epidermis The hair roots strengthen and the cellular respiration of the scalp, which stimulates the blood circulation, activated ascorbic acid Due to its reducing character, forms - together with benzoic acid - a stabilizing group of substances Procaine in its solutions. In this case, it replaces the alkali bisulfite or metabisulfite, which is found in a hair lotion are not to be used · Ascorbic acid can also be used to set and maintain the pH of the lotion, which results in resilience and shine in the hair

The other ingredients of the lotion are selected to meet the various cosmetic requirements Effects are sufficient; preferably substances are added which are known to stimulate hair growth.

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have a disinfecting effect, flake the scalp, grease or degrease the hair, and as desired also have a good ability to wet the hair so that it dries more quickly afterwards, as do substances for smelling, coloring the lotion, application liquid (water, organ «, solvent, miscible or immiscible with Water, together with the emulsifiers that may be necessary for emulsification.

The other components are selected, preferably from the known substances, also for the following effects:

a) to stimulate hair growth (acetic acid, benzoic acid, Cantarida tincture, Capsicum tincture, Sabadilla tincture, Asthyl alcohol, turpentine, xilol, pilocarpine, chloral hydrate, Quinine ^ vitamin and hormone preparations, mercury eloride, various sulfur compounds and elemental sulfur;

b) for disinfection (ethyl alcohol, isopropyl alcohol, Salicylic Acid, Phenoxyacetic Acid, Saphthalene, Resorcinol, various cupreine, quaternary ammonium salts);

c) to prevent dandruff on the scalp (glycerine, paraffin oil, vaseline);

d) to balance hair grease - greasing or degreasing (Glycerine, paraffin oil, vaseline, castor oil, asthyl alcohol or isopropyl alcohol, hydrocarbons such as hexane, vegetable oils, oleic acid esters, glycerine acetates);

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e) good hair wetting (asthyl alcohol, various surface active agents, such as liquid fatty acid soap, asthanolamines, cholesterol, etc.); for quick drying of the Hair, from the solution used (ethyl alcohol, hydrocarbons).

In the predominantly aqueous solutions in which the procaine (base) is insoluble, its soluble form is used Hydrochloride

The results obtained after using the lotion are as follows:

At the first signs of the onset of baldness in young men, treatment with the lotion will inhibit the disease Hair loss and dandruff on the scalp, making this treatment a method of baldness prophylaxis depicted

After a month of treatment, itchy skin will go away and flaking on the scalp.

After 2 to 3 months of treatment, the hair loss is stopped, with a tendency to alopecia in cases the regeneration of the hair begins

In the cases of alopecia and alopecia areate, successes are achieved in> 85% of the cases, with these disorders after

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16T7633

treatment with the lotion for 4 to 8 months disappear.

In the case of premature gray coloring of the hair at least occurs Significant repigmentation occurred 6 months after treatment.

The results represent mean values, which depending on the special case can fluctuate in both directions.

Local treatment with the lotion according to the invention is sufficient in cases of seborrhea, baldness and dandruff on the scalp or the tendency to alopecia «,

In the more stubborn cases and in general in the case of alopecia aerata, alopecia, premature graying of the hair and individual areas of alopecia aerata, the topical treatment with the lotion with the. general treatment (parenteral or oral) can be combined with a drug based on procaine, which is used in therapy against aging. Medicines against aging are known under numerous trade names, but the preparation "Gerovital H3 ⁿ " is preferably used according to the following recipe: Injectable solution, 3 ampoules of 5 ml per week, with 12 injections every two days and a break of 12 Days between injections; two pills of the same preparation must be taken daily during these breaks

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be taken, namely one pill an hour after the Main meals. The Gerovital has the following composition:

a) aliinjectable solution: 2 # procaine chlorohydrate, 0.12 # Benzoic acid, 0.10% potassium metabisulphite,

b) as coated tablets: 0.1 g procaine chlorohydrate, 0.006 g benzoic acid, 0.005 g potassium metabisulphite, 0.005 g disodium phosphate, Excipiens,

The lotions according to the invention can also be applied in cases of endocrine alopecia, but depending on the specific case, the applications must be coupled with a hormone treatment _e

The "Gerovital E ~ ^n" has the following composition:

a) as injectable solutions: 2 # procaine chlorohydrate, 0.12% benzoic acid, 0.10 f> potassium metabisulfite,

b) as coated tablets: 0.1 g procaine chlorohydrate, 0.006 g benzoic acid, 0.005 g potassium metabisulfite; 0.005 g of disodium phosphate and excipiens, for each dragee).

The application of these lotions is of course not in the case recommended for alopecia caused by X-rays

Examples of the application of the invention are given below:

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1617633 2.0 g 2.0 g. m. 9 · "» 0.12 g 0.12 g 1. It is put in water or a lotion an organic one 0.10 g 0.10 g Solvent prepared, the composition of which is like 0.4 g 0.4 g it follows: o, 7 β ■ 7.0 g Procaine-fiydrοChlorid 4.0 g 2.0 g Benzoic acid 58.4 g 3.0 g Ascorbic acid 100.0 g 100.0 g. lemon oil 2 * A lotion of the following composition is produced i The lotions are stored in brown bottles so that Ghina tincture Procaine Hydroculoride they are protected against daylight Glycerin Benzoic acid Ethyl alcohol, 96 jS-ig " Ascorbic acid distilled water ad lemon oil China tincture Triethanolamine Hexane distilled water ad

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Approximately 20 ml of the lotions are used to massage the scalp "every day is carried out during a period of 15 minutes" The massages are performed in circular movements working on the forehead and the skull and over the whole sp _m th head to Extending the heel »The hair must be washed once a week with a special hair soap, preferably with a sulfur soap ·

A dance test is performed by first applying the lotion to a limited area of the scalp Intolerance (allergy) is extremely rare as procaine is generally an antiallergic substance »

Literature passages considered:

P et M »M» Janot, Traite de pharmacis Paris, Vol. III, 1955-56, page 1286

üllmann's Encyclopedia of Techn »Chemistry, Vol. 10, 1958, Cosmetics, page 685 * 757, vol. 18, 1967t ascorbic acid, Page 220-222.

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Claims (1)

Claims 1, Lotion.-for hair care, to prevent hair loss, . as well as for the regeneration and repigmentation of the hair, characterized in that they contain procaine as the basic substance, in the form that can be dissolved in the lotion (as the base or chlorohydrate) and in a concentration of 0.55% benzoic acid and ascorbic acid, each in concentrations of 0.1-0.5 #, alone or together with the rest cosmetic ingredients used for softening, disinfecting, wetting hair, greasing or degreasing hair, smelling, Coloring the lotion, if necessary emulsifying, contains, the constituents in water and / or organic solvents, preferably lower alcohols, dissolved, emulsified or dispersed. 2 · Lotion according to claim 1, characterized in that the procaine concentration (base or chlorohydrate j 2 56 and the Benzoic acid and ascorbic acid concentrations are each 0.15 # 209816 / U 5 8 Haue documents (Art.? G 1 para. 2 no, 1 sentence 3 d .. other "*** * * u. -