EP4153128A1 - Zusammensetzung mit einer kombination aus jonzac-wärmefederwasser und einem extrakt aus centella asiatica und der reparatur-/heilwirkung davon - Google Patents

Zusammensetzung mit einer kombination aus jonzac-wärmefederwasser und einem extrakt aus centella asiatica und der reparatur-/heilwirkung davon

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Publication number
EP4153128A1
EP4153128A1 EP21726119.7A EP21726119A EP4153128A1 EP 4153128 A1 EP4153128 A1 EP 4153128A1 EP 21726119 A EP21726119 A EP 21726119A EP 4153128 A1 EP4153128 A1 EP 4153128A1
Authority
EP
European Patent Office
Prior art keywords
extract
composition
jonzac
water
asiatica
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21726119.7A
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English (en)
French (fr)
Inventor
Valérie CAUCHE
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Laboratoires Lea SAS
Original Assignee
Laboratoires Lea SAS
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Filing date
Publication date
Application filed by Laboratoires Lea SAS filed Critical Laboratoires Lea SAS
Publication of EP4153128A1 publication Critical patent/EP4153128A1/de
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
    • A61K35/08—Mineral waters; Sea water
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Definitions

  • the invention relates to a cosmetic and / or dermatological composition
  • a cosmetic and / or dermatological composition comprising a thermal water alone or combined with an extract of Cenfella asiatica, and its use for treating skin damage or lesions with a view to their healing and repair.
  • the initial phase of hemostasis (stopping the bleeding) lasts a few minutes. It is accompanied by a strong vascular response to vasoconstriction followed by increased capillary permeability and vasodilation. Thrombin and extravascular collagen contribute to the aggregation and activation of clot platelets. Many proteins are brought to the injury site by the rush of blood, which allows the fibrin clot (scab) to form.
  • the fibrin-fibronectin network provides a reservoir for the many growth factors released in the wound (PDGF, bFGF, TGFa, P) which are responsible for the activation of polynuclear neutrophils and macrophages. These cells then fight against infection, cleanse the wound and participate in local renutrition.
  • the inflammatory phase generally lasting between 2 and 4 days, takes place to cleanse the altered and necrotic tissue, thanks to the blood cells and the enzymes. It is accompanied by vasodilation leading to redness and sensations of heat and pain.
  • Neutrophils and monocytes are attracted to the wound not only by factors released by platelets, but also by bacterial peptides, complement factors and fibrin degradation products.
  • Polynuclear neutrophils are ⁇ the first leukocytes present in the wound; they release proteolytic enzymes such as elastase e ⁇ collagenases e ⁇ ensure a local an ⁇ i-infective function.
  • the monocytes attach themselves to the endothelial cells and migrate into the wound.
  • cytokines such as G IGF, TGF, TNF or PDGF. These substances amplify the inflammatory response e ⁇ stimulate the proliferation of fibroblasts, the production of collagen and more broadly, the proliferation of granulation tissue. Stimulation of skin immunity protects the lesion from infection.
  • This ⁇ phase corresponds to the transition between inflammation and wound healing by secreting growth factors that stimulate cell proliferation and matrix tissue formation.
  • the proliferative phase of tissue repair then takes place with the formation of granulation tissue.
  • This ⁇ phase lasts 10 to 15 days and corresponds to the proliferation of fibroblasts, angiogenesis and ⁇ the synthesis of the extracellular matrix.
  • This phase is largely dependent on cytokines (IGF 1, EGF, TNFa, TGFp, PDGF-BB) which promote the migration and proliferation of fibroblasts.
  • Fibroblasts synthesize a new extracellular matrix composed mainly at the beginning of type III collagen, fibronectin, proteoglycans (hyaluronic acid, chondroitin sulfate, etc.). They also participate in matrix remodeling by producing proteolytic enzymes don ⁇ metalloproteinases. The matrix also serves as a reservoir of growth factors.
  • the keratinocytes migrate on the matrix components e ⁇ allow the wound to re-epithelialize. Once the wound is closed by a monolayer of keratinocytes, they stop their migration, multiply and differentiate.
  • the final phase of skin healing the longest phase which can last between 2 months and 2 years, generally 1 year, corresponds to the maturation of the scar with a re-modeling of the tissues by the reorganization of the neosynthesized collagen fibers. which will eventually reform into healthy tissue.
  • the remodeling of the extracellular matrix goes through an inflammatory and proliferative phase lasting up to two months after wound closure. Gradually the granulation tissue becomes rare in fibroblasts, a denser collagen structure appears, while the vascular network is organized.
  • Matrix remodeling will increase the resistance of the scar considerably, up to 80-90% of its initial strength by the sixth week.
  • Fibronectin and hyaluronic acid are gradually replaced by collagens, elastic fibers and glycosaminoglycans (GAG) to restore structure to the epidermis.
  • the skin will remain more or less white as long as the level of melanocytes is not reconstituted.
  • the area weakened by the skin trauma remains sensitive for a long period of time until the dermal fibers regain their original conformation and the skin its initial appearance.
  • the composition of the extracellular matrix plays an important role in the migration of inflammatory cells, in the differentiation of connective cells and epithelial cells.
  • the healing process is characterized by significant changes in the extracellular matrix.
  • the extracellular matrix contains GAGs, fibronectin and type III collagen.
  • Fibronectin stimulates the migration of endothelial cells and fibroblasts into the inflammatory focus.
  • a scar should be soft and painless.
  • wound healing disorders can lead to dystrophic or hypertrophic (keloid) scars.
  • the healing depends on several factors, in particular nutritional, metabolic, endocrine or medicamentous; delayed healing is observed in the elderly, in cases of malnutrition or when taking certain medications for a long time.
  • occlusive treatment with a silicone dressing requires use over several months with an occlusion of at least 12 hours per day.
  • the main undesirable effects found are irritation, pruritus and skin maceration.
  • corticosteroids The main short-term side effects of corticosteroids are ⁇ increased appetite, weight gain, fluid retention, tendency to be aggressive with insomnia and nervousness, worsening of depression , e ⁇ frequently a transient imbalance of diabetes or arterial hypertension.
  • retinoids are known to be photosensitive, in particular isotretinoin. They are also potentially irritating, especially tretinoin.
  • hyaluronic acid Unlike other substances, hyaluronic acid has almost no risk of side effects. Nevertheless, allergic risks can arise. Also, the administration of hyaluronic acid is often done by injection.
  • active ingredients that have an effect on the healing of the skin are known, such as allantoin, zinc oxide, D-panthenol or even aloe vera and hydrocotyl (Cenfella asiatica).
  • Healing creams are also designed to help heal minor irritation, optimize healing conditions after cut, surgery, stitches, cosmetic surgery or even an accident.
  • the healing cream speeds up the time it takes for tissue to rebuild damaged skin and prevents scabs from forming so that the skin returns to its original appearance.
  • Thermal waters are known for their multiple properties: anti-free radicals, anti-inflammatory, healing, anti-irritant, soothing and decongestant.
  • Avène thermal spring water thus has the particularity of accelerating the skin repair processes, improving healing, e ⁇ reducing inflammation and itching phenomena.
  • La Roche-Posay thermal water contained in various products is used for example in combination with other active ingredients such as panthenol, madecassoside extracted from Cenfella asiatica or even hyaluronic acid, for its healing and decongestant properties , calming and anti-free radical for epidermal repair of the skin barrier.
  • active ingredients such as panthenol, madecassoside extracted from Cenfella asiatica or even hyaluronic acid, for its healing and decongestant properties , calming and anti-free radical for epidermal repair of the skin barrier.
  • Mon ⁇ Blanc thermal water, rich in sulfur, is particularly interesting because it is endowed with boron and manganese respectively healing and antioxidant.
  • Uriage thermal water due to the sulfur it contains, also appears to be very active in healing dermatological lesions.
  • VICHY® LABORATORIES® An ⁇ i-Stretch Cream® from VICHY® LABORATORIES® is known, for example, which describes a restorative composition comprising Vichy thermal water and an extract of Cenfella asiatica to prevent and correct stretch marks.
  • the cosmetic product Eau Thermale Jonzac Organic Surgras Nutritive® shower Gel 250 mL marketed by the LEA NATURE® group comprising Jonzac thermal water and an aqueous extract of Cenfella asiatica (pheasant ⁇ part of the composition of a UV absorbent (NATPURE UV-SORB®)) that cleanses the skin, soothes areas of dryness and strengthens the skin's protective barrier.
  • the Deep Repair Care® product marketed by the LEA NATURE® group discloses a repairing and healing cream comprising in particular, in addition to Jonzac thermal water, hydrolyzed hyaluronic acid (trade name PrimalHyal 300®), the healing properties of which have been demonstrated. In this product, Jonzac thermal water has the effect of improving the quality of the skin.
  • Patent document FR3023482 in the name of the Applicant describes a repair composition comprising Jonzac thermal water and an aqueous or hydroglycerine extract of Cenfella asiatica.
  • a problem that the invention proposes to solve is to propose a new active ingredient, hypoallergenic and non-irritant for the skin, used alone or in combination with other active (s), which has a healing and restorative activity aimed at reducing, partially or totally, the irregularities of the surface of the skin without showing the side effects of known treatments nor of negative interaction.
  • the Applicant has demonstrated a new effect of a well-known thermal water, namely Jonzac thermal water used for its regenerating properties (strengthens the skin barrier), anti-inflammatory (limits sensitivity and reactions linked to inflammation), soothing (calms the skin and limits redness) and hydrating (reinforces the skin's natural hydration).
  • Jonzac thermal water used for its regenerating properties (strengthens the skin barrier), anti-inflammatory (limits sensitivity and reactions linked to inflammation), soothing (calms the skin and limits redness) and hydrating (reinforces the skin's natural hydration).
  • the first object of the solution to this problem is a cosmetic and / or dermatological composition characterized in that it comprises, in a physiologically acceptable medium, Jonzac thermal water and a hydroalcoholic extract of hydrocotyl (Cenfella asiatica) .
  • a cosmetic and / or dermatological composition characterized in that it comprises, in a physiologically acceptable medium, Jonzac thermal water, alone or in combination with other active agent (s). in particular a hydroalcoholic extract of hydrocotyl (Cenfella asiatica), for its use to promote healing and repair of skin damage or lesions.
  • active agent s
  • hydroalcoholic extract of hydrocotyl Cenfella asiatica
  • the invention relates to a cosmetic and / or dermatological composition characterized in that it comprises, in a physiologically acceptable medium, Jonzac thermal water and a hydroalcoholic extract of hydrocotyl (Cenfella asiatica).
  • Physiologically acceptable medium means a medium suitable for use in contact with human and animal cells, in particular epidermal cells, without similar toxicity, irritation, undue allergic response, e ⁇ commensurate with a benefit / ratio. reasonable risk.
  • Such a physiologically acceptable medium may include known excipients used in cosmetics and dermatology. Those skilled in the art will take care to choose the physiologically acceptable medium so that it does not harm the advantageous properties of the compositions according to the invention.
  • Jonzac thermal water is hyperthermal water (emergence temperature 62 ° C), bacteriologically pure and isotonic, with a pH of 6.95.
  • Jonzac thermal water is more particularly a sulphide, mixed sulphate, sodium chloride type water, rich in trace elements and hypermineralized. It is more particularly composed of bicarbonates 193 mg / l, sulphates 2400 mg / l, chlorides 2100 mg / l, ammonium 1.8 mg / l, calcium 470 mg / l, magnesium 90 mg / l, potassium 100 mg / l, sodium 1600 mg / l, strontium 16 mg / l, silica 10 mg / l, zinc 0.04 mg / l, lithium 2.1 mg / l, copper ⁇ 0 , 02 mg / l, manganese ⁇ 0.005 mg / l, fluoride ⁇ 0.0017 mg / l, boron 3.6 mg / l, selenium ⁇ 0.005 mg / l, aluminum 0.05 mg / l .
  • Jonzac thermal water is preferably used in the composition according to the invention, alone or in combination with other active agent (s), at a concentration of between 5% e ⁇ 99, 5% by weight of the total weight of the composition (w / w), for example 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60% , 65%, 70%, 75%, 80%, 85%, 90%, 95%, preferably 99.4% when it is ⁇ used alone e ⁇ 30% when it is ⁇ associated in particular with a hydroalcoholic extract of hydrocotyl (Centella asiatica).
  • active agent s
  • the hydroalcoholic extract of hydrocotyl (Centella asiatica) is preferably obtained from the aerial parts, ground and extracted with a water and ethanol mixture.
  • Centella asiatica belongs to the Apiaceae family, to the genus Centella e ⁇ to the species Centella asiatica (L.) Urb. There are more particularly 3 varieties: Centella asiatica Var. typica, Centella asiatica Var. abyssinica e ⁇ Centella asiatica Var. floridana.
  • Centella asiatica advantageously contain: carbohydrates, represented by 4.5% of ose (rhamnose, arabinose, fructose); osides such as 2% oligosaccharides (sucrose, raffinose and cenfellose) e ⁇ 9% polysaccharides (pectins and mucilages); proteins, in particular proteins (15 to 20%) and amino acids (lysine, alanine, phenylalanine, serine, aspartic acids and glutamic acids); traces of lipids (palmitic, oleic, linoleic, stearic, lignoceric and elaidic acids); about 10% of mineral matter such as calcium, phosphorus, iron ...; phenolic compounds:
  • flavonoids flavonols derived from quercfin (isoquercfin) and kaempferol (asfragaline),
  • saponins (genins and their glycosidic esters):
  • centellasapogenol A centellasaponin A
  • sceffoleoside A centellasapogenol A
  • carotenoids carotenes (provitamin A); traces of alkaloids: hydrocotylin; vitamins: B vitamins and 0.01% vitamin C (ascorbic acid); traces of essential oil (0.01%), composed of:
  • beta-caryophyllene alpha- and beta-selinene, humulene, allo-aromadendrene, farnesene, alpha-copaene, beta-elemene, delta-cadinene, germacrene D, etc.
  • polyenes and polyines resins
  • the hydroalcoholic extract of hydrocotyl (Cenfella asiatica) is more preferably obtained from the aerial parts of Cenfella, mainly leaves, cut, dried and then ground into powder.
  • the resulting powder is heated to reflux with ethanol (36%) at a ratio of 1: 6.
  • the extract is filtered and mixed with propylene glycol (80% in water).
  • the hydroalcoholic extract of Cenfella asiafica used in the composition according to the invention is advantageously separated from the plant residues and dried to obtain a pale yellow to ocher powder, dispersible in fatty phase e ⁇ soluble for example at 1% in butylene glycol and propylene glycol after heating at 45 ° C for 5 minutes.
  • the hydroalcoholic extract of Cenfella asiatica es ⁇ dispersed in an oily phase or glycerin or another solvent of the same type, before being introduced in the aqueous phase.
  • the hydroalcoholic extract of Cenfella asiatica preferably contains at least 25% of triterpenoids by weight of the total weight of the extract.
  • the mainly extracted triterpenoids saponins are asiaticosides and madecassosides. There are other saponins extracted at a minority percentage (centelloside, brahmoside e ⁇ cenfella saponin B, C e ⁇ D).
  • Triterpene genins are also found in the extract: asian acid, madecassic acid and madasiatic acid.
  • Asiaticoside, madecassoside, asiatic acid e ⁇ madecassic acid preferentially e ⁇ mainly extracts are particularly interesting for their healing activity, in particular for treating light scars e ⁇ hypertrophic and burns by promoting re -epithelialization e ⁇ by stimulating collagen synthesis.
  • the hydroalcoholic extract of Cenfella asiatica is preferably used in the composition according to the invention at a concentration of between 0.001% and 5% by weight of the total weight of the composition, for example 0.01%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 2% , 3%, 4%, more preferably 0.1%.
  • the composition according to the invention preferably comprises Jonzac thermal spring water at a concentration of between 5% e ⁇ 99.5% by weight of the total weight of the composition e ⁇ the hydroalcoholic extract of hydrocotyl (Cenfella asiatica) at a concentration between 0.001% e ⁇ 5% by weight of the total weight of the composition, more preferably 30% Jonzac thermal water e ⁇ 0.1% hydroalcoholic extract of hydrocotyl (Cenfella asiatica).
  • the composition according to the invention also comprises hyaluronic acid (only when the composition does indeed comprise at least Jonzac thermal water and the hydroalcoholic extract of Cenfella asiatica), a hydroxyproline and its derivatives such as dipalmitoyl hydroxyproline, a hydrolyzed protein of lupine, a seaweed extract such as an aqueous extract of brown algae such as wrack and kelp rich in protein or an oily extract of green algae such as alaria rich in omega 3, 6 and 9, oligosaccharides (prebiotics), zinc PCA, an extract of Malva Sylvestris (Mallow), an extract of chamomile in particular a floral water of chamomile flowers (Anthrobs nobilis Flower Water), an extract of witch hazel (Hamamelis Virginiana Leaf Water ), an extract of aloe vera, ceramides such as N-oleoyl-phytosphingosine (or ceramide NP), taken alone or in combination.
  • the composition according to the invention further comprises a hydrolyzed lupine protein, a floral water of chamomile flowers (Anthraps nobilis Flower Water), an extract of aloe vera and / or N-oleoyl-phytosphingosine (or ceramide NP), even more preferably a floral water of chamomile flowers (Anthraps nobilis Flower Water) or an extract of aloe vera and a hydrolyzed protein of lupine or N-oleoyl-phytosphingosine (or ceramide NP).
  • a hydrolyzed lupine protein a floral water of chamomile flowers (Anthraps nobilis Flower Water)
  • an extract of aloe vera and / or N-oleoyl-phytosphingosine or ceramide NP
  • Another subject of the invention relates to a cosmetic and / or dermatological composition
  • a cosmetic and / or dermatological composition comprising, in a physiologically acceptable medium, Jonzac thermal water, taken alone as an active or in combination with other active agent (s). (s), for use in promoting wound healing.
  • active agent is meant a compound known for its properties for promoting healing and repairing skin damage or lesions.
  • composition thus used does not include hyaluronic acid as another active ingredient.
  • Hyaluronic acid is widely available commercially or can be prepared or extracted by any technique known to those skilled in the art.
  • This polymer can be natural or synthetic, hydrolyzed (PrimalFlyal TM) or not.
  • acid is meant hyaluronic hyaluronic acid itself, its homologues, analogs, derivatives, complexes, esters, fragments e ⁇ subunits.
  • Hyaluronic acid exists naturally in the form of unsafe disaccharides and can also be chemically modified in order to improve its absorption characteristics, such as for example by modifications of the hydroxyl groups by an ether bond to obtain an ether bond to obtain an ether bond. conjugated cysteine-hyaluronic acid or the formation of an ethyl ether of 1 - cysteine (C) via an amide bond, and / or crosslinked (having intra- or inter-chain bridges).
  • the composition according to the invention comprises, in a physiologically acceptable medium, Jonzac thermal water taken alone as an active agent, for its use to promote healing.
  • skin damage or lesions denotes a visible change (alteration) in the structure of the skin due to an external (scratching or aggression) or internal (pathology) cause.
  • non-oozing damage or lesions on the skin of the face or body, superficial to medium resulting from a surgical intervention (stitches), cuts, Abrasions after the wound has dried out, cosmetic procedures such as peeling, laser, permanent hair removal, tattooing, tattoo removal or even medium to major damage or lesions such as chapped skin, sores, pulpitis, burns.
  • Jonzac thermal water is used alone, that is to say as the sole active principle, in a cosmetic and / or dermatological composition comprising a physiologically acceptable medium, to promote healing.
  • Jonzac thermal water is used in combination with other active agent (s), preferably a hydroalcoholic extract of hydrocotyl (Cenfella asiatica), said composition not comprising acid. hyaluronic in tan ⁇ than other active, in a cosmetic and / or dermatological composition according to the invention comprising a physiologically acceptable medium, to promote healing.
  • active agent preferably a hydroalcoholic extract of hydrocotyl (Cenfella asiatica)
  • hyaluronic in tan ⁇ than other active in a cosmetic and / or dermatological composition according to the invention comprising a physiologically acceptable medium, to promote healing.
  • Another object of the invention relates to a cosmetic and / or dermatological composition
  • a cosmetic and / or dermatological composition comprising, in a physiologically medium acceptable, Jonzac thermal water and a hydroalcoholic extract of hydrocotyl (Cenfella asiatica), for its use to promote healing and repair of skin damage or lesions.
  • Another subject of the invention relates to the use of a cosmetic and / or dermatological composition
  • a cosmetic and / or dermatological composition comprising, in a physiologically acceptable medium, Jonzac thermal water and a hydroalcoholic extract of hydrocotyl (Cenfella asiatica) to fight against skin aging and skin imperfections.
  • cutaneous aging e ⁇ skin imperfections By combating cutaneous aging e ⁇ skin imperfections, is meant, for example, to maintain or restore the hydration of the skin and the biomechanical properties of the skin, for example to firm the skin, ef / or prevent or delay the appearance of signs of aging of the skin, in particular the appearance of wrinkles, fine lines, e ⁇ dry skin, e ⁇ loss of firmness of the skin or to slow the effects thereof.
  • Antioxidant activity acts on free radicals and prevents cells from oxidizing, and indirectly, the appearance of wrinkles.
  • the antioxidant activity also prevents the oxidation of sebum on oily skin and therefore minimizes blemishes.
  • compositions preferably used according to the invention are provided in a form suitable for topical administration.
  • topical formulations For illustrative examples of topical formulations according to the invention, one can quote an optionally tinted cream, an oil-in-water emulsion (O / W), a water-in-oil emulsion (W / O), a gel, a gel. -crème, a water, a balm for the body or the lips, an ointment or a serum.
  • O / W oil-in-water emulsion
  • W / O water-in-oil emulsion
  • gel a gel. -crème
  • a water a balm for the body or the lips
  • an ointment or a serum for illustrative examples of topical formulations according to the invention.
  • the aim of the study is to assess the modulating effects of 3 test items on skin healing: - Test A: Jonzac thermal water (ETJ) preserved (99.4% pure ETJ and 0.6% preservatives);
  • Test B 4% hydroalcoholic extract Cenfella asiatica (dosed at 25% triterpenes) dissolved in 86.4% propanediol and 9.6% water;
  • the study is performed on human HaCaT keratinocytes.
  • the HaCaT cells are cultured, according to standard laboratory procedures, at 37 ° C. in a humid atmosphere of air-CC> 2 (95% -5%).
  • the principle of the test is based on measuring the ability of a population of monolayer cells cultured in the absence and presence of the test element, to close an artificial wound produced by scratching.
  • the scrape wound healing test involves manually creating an artificial cell-free space using a pipette tip in a 100% confluent cell monolayer and evaluating the cells' ability to fill that space.
  • the cell suspension After counting with the Malassez cell, the cell suspension is inoculated into 24-fold plates, at a rate of 100 x 10 3 cells / well. The cultures are placed in an incubator and incubated in an air-CC> 2 (95% / 5%) atmosphere until confluent monolayers are obtained.
  • a specific field is selected using an inverted microscope and recorded after capturing the image with a camera. After acquisition and recording of the images, the cultures are placed in an oven and incubated at 37 ° C for 2 to 3 days, in an air-CC> 2 atmosphere. The media are renewed every day, after twice daily measurement of the wounds, using an image analysis system (PERFECT IMAGE®).
  • the test is performed on human HaCaT keratinocytes.
  • the test element is introduced into the test medium after the completion of the “wounds” (T0).
  • the wound closure kinetics were established on 5 measurement points: T0 (Oh), Tl (8h), T2 (24h), T3 (32h) e ⁇ T4 (48h).
  • the area of the wounds was measured at the level of the control and treated luffs.
  • the association of Jonzac thermal water with a hydroalcoholic extract of Centella asiatica has a healing effect superior to the Jonzac thermal water taken alone and to the hydroalcoholic exfrai ⁇ of Centella asiatica alone at 24h e ⁇ 32h.
  • Example 2 Evaluation of the antioxidant power of the association between Jonzac thermal water and a hvdroalcoholic extract of Centella asiatica A test ⁇ DPPH is carried out.
  • the reduction of the free radical DPPH (2,2'-diphenyl-1-picryl hydrazyl) by an antioxidant can be followed by UV-Visible spectrometry, by measuring the decrease in absorbance at 517 nm caused by the antioxidants.
  • DPPH 2.2 Diphenyl 1 picryl hydrazyl
  • DPPH Diphenyl 1 picryl hydrazyl
  • the activity of scavenging the DPPH radical was measured and expressed in mitioI trolox equivalent.
  • Test B 4% hydroalcoholic extract Cenfella asiatica (dosed at 25% triterpenes) dissolved in 86.4% propanediol and 9.6% water;
  • Test C 50% test A + 50% test B
  • Test D 50% distilled water + 50% test B
  • the hydroalcoholic extract of Cenfella asiatica which contains components such as triterpenes recognized as antioxidants, has an antioxidant power of 2785.15 mioI equivalent ⁇ rolox / L.
  • Jonzac thermal water potentiates the antioxidant effect of the hydroalcoholic extract of Cenfella asiatica, when they are associated. This ⁇ synergistic effect is particularly surprising.
  • Example 3 W / O emulsion with Jonzac thermal water and extract of
  • Centella asiatica Centella asiatica
  • Centella asiatica Centella asiatica
  • Example 6 Treatment water with Jonzac thermal water and extract of
  • Centella asiatica Centella asiatica
  • Example 7 Gel with Jonzac thermal water and Centella asiatica extract

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EP21726119.7A 2020-05-20 2021-05-19 Zusammensetzung mit einer kombination aus jonzac-wärmefederwasser und einem extrakt aus centella asiatica und der reparatur-/heilwirkung davon Pending EP4153128A1 (de)

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FR2005210A FR3110400B1 (fr) 2020-05-20 2020-05-20 Composition alliant une eau thermale de Jonzac et un extrait de Centella asiatica et son effet réparateur/cicatrisant
PCT/EP2021/063268 WO2021233988A1 (fr) 2020-05-20 2021-05-19 Composition alliant une eau thermale de jonzac et un extrait de centella asiatica et son effet reparateur/cicatrisant

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EP4153128A1 true EP4153128A1 (de) 2023-03-29

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CN117898962A (zh) * 2024-01-23 2024-04-19 江南大学 一种具有皮肤修复功效的羟基积雪草苷组合物及其应用

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FR2722691A1 (fr) * 1994-07-22 1996-01-26 Oreal Composition cosmetique et/ou dermatologique conten lutter contre l'acne ou le vieillissement ant de l'eau thermale ou minerale et un actif pour
FR3023482B1 (fr) * 2014-07-11 2016-07-15 Laboratoires Lea Extrait hydroglycerine d'ombellifere pour un usage cosmetique
FR3056106B1 (fr) * 2016-09-16 2020-06-05 Laboratoires Lea Utilisation cosmetique d’une composition comprenant une eau thermale en association avec au moins deux autres agents actifs pour l’amelioration de l’aspect general de la peau

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