EP4138769A1 - Color-stable sunscreen - Google Patents
Color-stable sunscreenInfo
- Publication number
- EP4138769A1 EP4138769A1 EP21714852.7A EP21714852A EP4138769A1 EP 4138769 A1 EP4138769 A1 EP 4138769A1 EP 21714852 A EP21714852 A EP 21714852A EP 4138769 A1 EP4138769 A1 EP 4138769A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- preparation
- diethylamino
- inci
- use according
- hydroxybenzoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000516 sunscreening agent Substances 0.000 title description 7
- 230000000475 sunscreen effect Effects 0.000 title description 6
- 238000002360 preparation method Methods 0.000 claims abstract description 109
- 239000002537 cosmetic Substances 0.000 claims abstract description 34
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 claims abstract description 29
- FDATWRLUYRHCJE-UHFFFAOYSA-N diethylamino hydroxybenzoyl hexyl benzoate Chemical compound CCCCCCOC(=O)C1=CC=CC=C1C(=O)C1=CC=C(N(CC)CC)C=C1O FDATWRLUYRHCJE-UHFFFAOYSA-N 0.000 claims abstract description 28
- 229960001630 diethylamino hydroxybenzoyl hexyl benzoate Drugs 0.000 claims abstract description 21
- -1 compounds glyceryl stearate citrate Chemical class 0.000 claims description 20
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 18
- FRGIOIALHUOUTR-UHFFFAOYSA-N 2-[4-(diethylamino)-2-hydroxybenzoyl]hexyl benzoate Chemical compound C=1C=C(N(CC)CC)C=C(O)C=1C(=O)C(CCCC)COC(=O)C1=CC=CC=C1 FRGIOIALHUOUTR-UHFFFAOYSA-N 0.000 claims description 11
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 10
- 239000000839 emulsion Substances 0.000 claims description 7
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 6
- 229910021645 metal ion Inorganic materials 0.000 claims description 6
- 239000000049 pigment Substances 0.000 claims description 6
- DLAHAXOYRFRPFQ-UHFFFAOYSA-N dodecyl benzoate Chemical compound CCCCCCCCCCCCOC(=O)C1=CC=CC=C1 DLAHAXOYRFRPFQ-UHFFFAOYSA-N 0.000 claims description 5
- 229910052742 iron Inorganic materials 0.000 claims description 5
- 239000002304 perfume Substances 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 claims description 4
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 4
- 239000000539 dimer Substances 0.000 claims description 4
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 4
- DXGLGDHPHMLXJC-UHFFFAOYSA-N oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- JGUMTYWKIBJSTN-UHFFFAOYSA-N 2-ethylhexyl 4-[[4,6-bis[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 JGUMTYWKIBJSTN-UHFFFAOYSA-N 0.000 claims description 3
- 239000003995 emulsifying agent Substances 0.000 claims description 3
- UVCJGUGAGLDPAA-UHFFFAOYSA-N ensulizole Chemical class N1C2=CC(S(=O)(=O)O)=CC=C2N=C1C1=CC=CC=C1 UVCJGUGAGLDPAA-UHFFFAOYSA-N 0.000 claims description 3
- 150000002170 ethers Chemical class 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- HEOCBCNFKCOKBX-RELGSGGGSA-N (1s,2e,4r)-4,7,7-trimethyl-2-[(4-methylphenyl)methylidene]bicyclo[2.2.1]heptan-3-one Chemical compound C1=CC(C)=CC=C1\C=C/1C(=O)[C@]2(C)CC[C@H]\1C2(C)C HEOCBCNFKCOKBX-RELGSGGGSA-N 0.000 claims description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 2
- 229940100555 2-methyl-4-isothiazolin-3-one Drugs 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- 235000021355 Stearic acid Nutrition 0.000 claims description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 2
- XVAMCHGMPYWHNL-UHFFFAOYSA-N bemotrizinol Chemical compound OC1=CC(OCC(CC)CCCC)=CC=C1C1=NC(C=2C=CC(OC)=CC=2)=NC(C=2C(=CC(OCC(CC)CCCC)=CC=2)O)=N1 XVAMCHGMPYWHNL-UHFFFAOYSA-N 0.000 claims description 2
- 229940067596 butylparaben Drugs 0.000 claims description 2
- DHNRXBZYEKSXIM-UHFFFAOYSA-N chloromethylisothiazolinone Chemical compound CN1SC(Cl)=CC1=O DHNRXBZYEKSXIM-UHFFFAOYSA-N 0.000 claims description 2
- WSDISUOETYTPRL-UHFFFAOYSA-N dmdm hydantoin Chemical compound CC1(C)N(CO)C(=O)N(CO)C1=O WSDISUOETYTPRL-UHFFFAOYSA-N 0.000 claims description 2
- 229940075529 glyceryl stearate Drugs 0.000 claims description 2
- 150000002334 glycols Chemical class 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical compound CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 claims description 2
- 229960002216 methylparaben Drugs 0.000 claims description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 2
- 229960001679 octinoxate Drugs 0.000 claims description 2
- FMJSMJQBSVNSBF-UHFFFAOYSA-N octocrylene Chemical group C=1C=CC=CC=1C(=C(C#N)C(=O)OCC(CC)CCCC)C1=CC=CC=C1 FMJSMJQBSVNSBF-UHFFFAOYSA-N 0.000 claims description 2
- 229960000601 octocrylene Drugs 0.000 claims description 2
- 229960001173 oxybenzone Drugs 0.000 claims description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N p-hydroxybenzoic acid methyl ester Natural products COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N p-hydroxybenzoic acid propyl ester Natural products CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 229960003415 propylparaben Drugs 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 229940045898 sodium stearoyl glutamate Drugs 0.000 claims description 2
- KDHFCTLPQJQDQI-BDQAORGHSA-M sodium;(4s)-4-amino-5-octadecanoyloxy-5-oxopentanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC(=O)OC(=O)[C@@H](N)CCC([O-])=O KDHFCTLPQJQDQI-BDQAORGHSA-M 0.000 claims description 2
- 239000008117 stearic acid Substances 0.000 claims description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- 229940080284 cetyl sulfate Drugs 0.000 claims 1
- LPTIRUACFKQDHZ-UHFFFAOYSA-N hexadecyl sulfate;hydron Chemical compound CCCCCCCCCCCCCCCCOS(O)(=O)=O LPTIRUACFKQDHZ-UHFFFAOYSA-N 0.000 claims 1
- 229940061570 polyglyceryl-10 stearate Drugs 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- 238000005259 measurement Methods 0.000 description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 239000004909 Moisturizer Substances 0.000 description 4
- 229910052782 aluminium Inorganic materials 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 230000001333 moisturizer Effects 0.000 description 4
- 230000003595 spectral effect Effects 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 239000000230 xanthan gum Substances 0.000 description 4
- 229920001285 xanthan gum Polymers 0.000 description 4
- 235000010493 xanthan gum Nutrition 0.000 description 4
- 229940082509 xanthan gum Drugs 0.000 description 4
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 150000004676 glycans Polymers 0.000 description 3
- 229920002674 hyaluronan Polymers 0.000 description 3
- 229960003160 hyaluronic acid Drugs 0.000 description 3
- VVOAZFWZEDHOOU-UHFFFAOYSA-N magnolol Chemical compound OC1=CC=C(CC=C)C=C1C1=CC(CC=C)=CC=C1O VVOAZFWZEDHOOU-UHFFFAOYSA-N 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 229940032147 starch Drugs 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- YVLPJIGOMTXXLP-UHFFFAOYSA-N 15-cis-phytoene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CC=CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C YVLPJIGOMTXXLP-UHFFFAOYSA-N 0.000 description 2
- PBFGMXZRJIUGKU-UHFFFAOYSA-N 3-decanoyloxybutyl decanoate Chemical compound CCCCCCCCCC(=O)OCCC(C)OC(=O)CCCCCCCCC PBFGMXZRJIUGKU-UHFFFAOYSA-N 0.000 description 2
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 description 2
- ZCTQGTTXIYCGGC-UHFFFAOYSA-N Benzyl salicylate Chemical compound OC1=CC=CC=C1C(=O)OCC1=CC=CC=C1 ZCTQGTTXIYCGGC-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- XTJFFFGAUHQWII-UHFFFAOYSA-N Dibutyl adipate Chemical compound CCCCOC(=O)CCCCC(=O)OCCCC XTJFFFGAUHQWII-UHFFFAOYSA-N 0.000 description 2
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 235000019501 Lemon oil Nutrition 0.000 description 2
- 240000003183 Manihot esculenta Species 0.000 description 2
- 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 239000004904 UV filter Substances 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- ISAOCJYIOMOJEB-UHFFFAOYSA-N benzoin Chemical compound C=1C=CC=CC=1C(O)C(=O)C1=CC=CC=C1 ISAOCJYIOMOJEB-UHFFFAOYSA-N 0.000 description 2
- SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 description 2
- 229940114374 butylene glycol dicaprylate Drugs 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- QMVPMAAFGQKVCJ-UHFFFAOYSA-N citronellol Chemical compound OCCC(C)CCC=C(C)C QMVPMAAFGQKVCJ-UHFFFAOYSA-N 0.000 description 2
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 description 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
- 229940100539 dibutyl adipate Drugs 0.000 description 2
- RXKJFZQQPQGTFL-UHFFFAOYSA-N dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 description 2
- PKPOVTYZGGYDIJ-UHFFFAOYSA-N dioctyl carbonate Chemical compound CCCCCCCCOC(=O)OCCCCCCCC PKPOVTYZGGYDIJ-UHFFFAOYSA-N 0.000 description 2
- 239000001245 distarch phosphate Substances 0.000 description 2
- 235000013804 distarch phosphate Nutrition 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000000265 homogenisation Methods 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000010501 lemon oil Substances 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
- AGBQKNBQESQNJD-UHFFFAOYSA-N lipoic acid Chemical compound OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
- 239000010502 orange oil Substances 0.000 description 2
- OSORMYZMWHVFOZ-UHFFFAOYSA-N phenethyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCCC1=CC=CC=C1 OSORMYZMWHVFOZ-UHFFFAOYSA-N 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 230000036572 transepidermal water loss Effects 0.000 description 2
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- CRDAMVZIKSXKFV-FBXUGWQNSA-N (2-cis,6-cis)-farnesol Chemical compound CC(C)=CCC\C(C)=C/CC\C(C)=C/CO CRDAMVZIKSXKFV-FBXUGWQNSA-N 0.000 description 1
- KAZSKMJFUPEHHW-UHFFFAOYSA-N (2E)-3-[5-(1,1-dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl]-1-(4-hdyroxyphenyl)-2-propen-1-one Natural products COC1=CC(O)=C(C(C)(C)C=C)C=C1C=CC(=O)C1=CC=C(O)C=C1 KAZSKMJFUPEHHW-UHFFFAOYSA-N 0.000 description 1
- 239000000260 (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol Substances 0.000 description 1
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 1
- KRLBLPBPZSSIGH-CSKARUKUSA-N (6e)-3,7-dimethylnona-1,6-dien-3-ol Chemical compound CC\C(C)=C\CCC(C)(O)C=C KRLBLPBPZSSIGH-CSKARUKUSA-N 0.000 description 1
- 239000001244 (E)-1-(2,6,6-trimethyl-1-cyclohex-2-enyl)pent-1-en-3-one Substances 0.000 description 1
- QMVPMAAFGQKVCJ-SNVBAGLBSA-N (R)-(+)-citronellol Natural products OCC[C@H](C)CCC=C(C)C QMVPMAAFGQKVCJ-SNVBAGLBSA-N 0.000 description 1
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 description 1
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 1
- VPKMGDRERYMTJX-XEHSLEBBSA-N (e)-1-[(1r)-2,6,6-trimethylcyclohex-2-en-1-yl]pent-1-en-3-one Chemical compound CCC(=O)\C=C\[C@H]1C(C)=CCCC1(C)C VPKMGDRERYMTJX-XEHSLEBBSA-N 0.000 description 1
- SBLKVIQSIHEQOF-OWOJBTEDSA-N (e)-octadec-9-enedioic acid Chemical compound OC(=O)CCCCCCC\C=C\CCCCCCCC(O)=O SBLKVIQSIHEQOF-OWOJBTEDSA-N 0.000 description 1
- 229940015975 1,2-hexanediol Drugs 0.000 description 1
- 229940031723 1,2-octanediol Drugs 0.000 description 1
- OLUJUQKZMDLFII-UHFFFAOYSA-N 1-phenyloct-1-en-3-ol Chemical compound CCCCCC(O)C=CC1=CC=CC=C1 OLUJUQKZMDLFII-UHFFFAOYSA-N 0.000 description 1
- YVLPJIGOMTXXLP-UUKUAVTLSA-N 15,15'-cis-Phytoene Natural products C(=C\C=C/C=C(\CC/C=C(\CC/C=C(\CC/C=C(\C)/C)/C)/C)/C)(\CC/C=C(\CC/C=C(\CC/C=C(\C)/C)/C)/C)/C YVLPJIGOMTXXLP-UUKUAVTLSA-N 0.000 description 1
- YVLPJIGOMTXXLP-BAHRDPFUSA-N 15Z-phytoene Natural products CC(=CCCC(=CCCC(=CCCC(=CC=C/C=C(C)/CCC=C(/C)CCC=C(/C)CCC=C(C)C)C)C)C)C YVLPJIGOMTXXLP-BAHRDPFUSA-N 0.000 description 1
- PPVDHXWQWABSBC-UHFFFAOYSA-N 2-(2,6-diethyl-4-hydroxy-3,5-dimethoxyphenyl)-2-hexyl-1,3-dioxane-4,6-dione Chemical compound CCC=1C(OC)=C(O)C(OC)=C(CC)C=1C1(CCCCCC)OC(=O)CC(=O)O1 PPVDHXWQWABSBC-UHFFFAOYSA-N 0.000 description 1
- PFPQMWRASYNLMZ-LGIMBNBCSA-N 2-(3,4-dihydroxyphenyl)-3-[(2s,3r,4r,5s,6r)-3,4-dihydroxy-5-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[[(2r,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxy-5,7-dihydroxychromen-4-one Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](O)[C@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 PFPQMWRASYNLMZ-LGIMBNBCSA-N 0.000 description 1
- DNRJTBAOUJJKDY-UHFFFAOYSA-N 2-Acetyl-3,5,5,6,8,8-hexamethyl-5,6,7,8- tetrahydronaphthalene Chemical compound CC(=O)C1=C(C)C=C2C(C)(C)C(C)CC(C)(C)C2=C1 DNRJTBAOUJJKDY-UHFFFAOYSA-N 0.000 description 1
- HMKKIXGYKWDQSV-SDNWHVSQSA-N 2-Pentyl-3-phenyl-2-propenal Chemical compound CCCCC\C(C=O)=C/C1=CC=CC=C1 HMKKIXGYKWDQSV-SDNWHVSQSA-N 0.000 description 1
- CZVOIAOPRGNENY-UHFFFAOYSA-N 2-butyloctyl 2-hydroxybenzoate Chemical compound CCCCCCC(CCCC)COC(=O)C1=CC=CC=C1O CZVOIAOPRGNENY-UHFFFAOYSA-N 0.000 description 1
- CLAHOZSYMRNIPY-UHFFFAOYSA-N 2-hydroxyethylurea Chemical compound NC(=O)NCCO CLAHOZSYMRNIPY-UHFFFAOYSA-N 0.000 description 1
- QWGRWMMWNDWRQN-UHFFFAOYSA-N 2-methylpropane-1,3-diol Chemical compound OCC(C)CO QWGRWMMWNDWRQN-UHFFFAOYSA-N 0.000 description 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- WHBKVWBGTBULQY-UHFFFAOYSA-N 2-propylheptyl octanoate Chemical compound CCCCCCCC(=O)OCC(CCC)CCCCC WHBKVWBGTBULQY-UHFFFAOYSA-N 0.000 description 1
- GOLORTLGFDVFDW-UHFFFAOYSA-N 3-(1h-benzimidazol-2-yl)-7-(diethylamino)chromen-2-one Chemical compound C1=CC=C2NC(C3=CC4=CC=C(C=C4OC3=O)N(CC)CC)=NC2=C1 GOLORTLGFDVFDW-UHFFFAOYSA-N 0.000 description 1
- JRJBVWJSTHECJK-PKNBQFBNSA-N 3-Methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one Chemical compound CC(=O)C(\C)=C\C1C(C)=CCCC1(C)C JRJBVWJSTHECJK-PKNBQFBNSA-N 0.000 description 1
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 description 1
- FGGSPCRNKDZEKY-UHFFFAOYSA-N 3-hexoxypentane-1,2,3-triol Chemical compound CCCCCCOC(O)(CC)C(O)CO FGGSPCRNKDZEKY-UHFFFAOYSA-N 0.000 description 1
- OXYRENDGHPGWKV-UHFFFAOYSA-N 3-methyl-5-phenylpentan-1-ol Chemical compound OCCC(C)CCC1=CC=CC=C1 OXYRENDGHPGWKV-UHFFFAOYSA-N 0.000 description 1
- LFESLSYSZQYEIZ-UHFFFAOYSA-N 3-octanoyloxybutyl octanoate Chemical compound CCCCCCCC(=O)OCCC(C)OC(=O)CCCCCCC LFESLSYSZQYEIZ-UHFFFAOYSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- MSHFRERJPWKJFX-UHFFFAOYSA-N 4-Methoxybenzyl alcohol Chemical compound COC1=CC=C(CO)C=C1 MSHFRERJPWKJFX-UHFFFAOYSA-N 0.000 description 1
- 229940073735 4-hydroxy acetophenone Drugs 0.000 description 1
- YVSNOTITPICPTB-UHFFFAOYSA-N 4-methyl-2-(2-methylpropyl)oxan-4-ol Chemical compound CC(C)CC1CC(C)(O)CCO1 YVSNOTITPICPTB-UHFFFAOYSA-N 0.000 description 1
- GUOCOOQWZHQBJI-UHFFFAOYSA-N 4-oct-7-enoxy-4-oxobutanoic acid Chemical compound OC(=O)CCC(=O)OCCCCCCC=C GUOCOOQWZHQBJI-UHFFFAOYSA-N 0.000 description 1
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 description 1
- PPDUYVZBBMHPQD-UHFFFAOYSA-N 6-cinnamylidenedodecyl 2-hydroxybenzoate Chemical compound C=1C=CC=CC=1C=CC=C(CCCCCC)CCCCCOC(=O)C1=CC=CC=C1O PPDUYVZBBMHPQD-UHFFFAOYSA-N 0.000 description 1
- 229910052582 BN Inorganic materials 0.000 description 1
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 1
- PZNSFCLAULLKQX-UHFFFAOYSA-N Boron nitride Chemical compound N#B PZNSFCLAULLKQX-UHFFFAOYSA-N 0.000 description 1
- QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 description 1
- 108010087806 Carnosine Proteins 0.000 description 1
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- OOCCDEMITAIZTP-QPJJXVBHSA-N Cinnamyl alcohol Natural products OC\C=C\C1=CC=CC=C1 OOCCDEMITAIZTP-QPJJXVBHSA-N 0.000 description 1
- WTEVQBCEXWBHNA-UHFFFAOYSA-N Citral Natural products CC(C)=CCCC(C)=CC=O WTEVQBCEXWBHNA-UHFFFAOYSA-N 0.000 description 1
- 244000183685 Citrus aurantium Species 0.000 description 1
- 235000007716 Citrus aurantium Nutrition 0.000 description 1
- 240000002319 Citrus sinensis Species 0.000 description 1
- 235000005976 Citrus sinensis Nutrition 0.000 description 1
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- YEVACTAGDANHRH-UHFFFAOYSA-N Coniferan Chemical compound CCC(C)(C)C1CCCCC1OC(C)=O YEVACTAGDANHRH-UHFFFAOYSA-N 0.000 description 1
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- 235000000638 D-biotin Nutrition 0.000 description 1
- 239000011665 D-biotin Substances 0.000 description 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 1
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 1
- DKMROQRQHGEIOW-UHFFFAOYSA-N Diethyl succinate Chemical compound CCOC(=O)CCC(=O)OCC DKMROQRQHGEIOW-UHFFFAOYSA-N 0.000 description 1
- 241000522215 Dipteryx odorata Species 0.000 description 1
- 240000002943 Elettaria cardamomum Species 0.000 description 1
- 239000005770 Eugenol Substances 0.000 description 1
- 241000004871 Evernia Species 0.000 description 1
- PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 description 1
- 239000005792 Geraniol Substances 0.000 description 1
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- BYTORXDZJWWIKR-UHFFFAOYSA-N Hinokiol Natural products CC(C)c1cc2CCC3C(C)(CO)C(O)CCC3(C)c2cc1O BYTORXDZJWWIKR-UHFFFAOYSA-N 0.000 description 1
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 description 1
- IUCVKTHEUWACFB-UHFFFAOYSA-N Licochalcone A Natural products COC1=CC=C(C(C)(C)C=C)C=C1C=CC(=O)C1=CC=C(O)C=C1 IUCVKTHEUWACFB-UHFFFAOYSA-N 0.000 description 1
- KAZSKMJFUPEHHW-DHZHZOJOSA-N Licochalcone A Chemical compound COC1=CC(O)=C(C(C)(C)C=C)C=C1\C=C\C(=O)C1=CC=C(O)C=C1 KAZSKMJFUPEHHW-DHZHZOJOSA-N 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- CQOVPNPJLQNMDC-UHFFFAOYSA-N N-beta-alanyl-L-histidine Natural products NCCC(=O)NC(C(O)=O)CC1=CN=CN1 CQOVPNPJLQNMDC-UHFFFAOYSA-N 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 206010063493 Premature ageing Diseases 0.000 description 1
- 208000032038 Premature aging Diseases 0.000 description 1
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 1
- 208000000453 Skin Neoplasms Diseases 0.000 description 1
- 244000028419 Styrax benzoin Species 0.000 description 1
- 235000000126 Styrax benzoin Nutrition 0.000 description 1
- 235000008411 Sumatra benzointree Nutrition 0.000 description 1
- 206010042496 Sunburn Diseases 0.000 description 1
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 1
- 230000037338 UVA radiation Effects 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- SLHPMAOXNSLXEH-ZGVCCVRISA-N [(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexyl] 5-oxopyrrolidine-2-carboxylate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)C1NC(=O)CC1 SLHPMAOXNSLXEH-ZGVCCVRISA-N 0.000 description 1
- 230000009692 acute damage Effects 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- OOCCDEMITAIZTP-UHFFFAOYSA-N allylic benzylic alcohol Natural products OCC=CC1=CC=CC=C1 OOCCDEMITAIZTP-UHFFFAOYSA-N 0.000 description 1
- WUOACPNHFRMFPN-UHFFFAOYSA-N alpha-terpineol Chemical compound CC1=CCC(C(C)(C)O)CC1 WUOACPNHFRMFPN-UHFFFAOYSA-N 0.000 description 1
- 235000010210 aluminium Nutrition 0.000 description 1
- 229940062909 amyl salicylate Drugs 0.000 description 1
- 230000001153 anti-wrinkle effect Effects 0.000 description 1
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 1
- 150000001558 benzoic acid derivatives Chemical class 0.000 description 1
- 229960002130 benzoin Drugs 0.000 description 1
- 239000001518 benzyl (E)-3-phenylprop-2-enoate Substances 0.000 description 1
- 229960002903 benzyl benzoate Drugs 0.000 description 1
- NGHOLYJTSCBCGC-QXMHVHEDSA-N benzyl cinnamate Chemical compound C=1C=CC=CC=1\C=C/C(=O)OCC1=CC=CC=C1 NGHOLYJTSCBCGC-QXMHVHEDSA-N 0.000 description 1
- JGQFVRIQXUFPAH-UHFFFAOYSA-N beta-citronellol Natural products OCCC(C)CCCC(C)=C JGQFVRIQXUFPAH-UHFFFAOYSA-N 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 235000005300 cardamomo Nutrition 0.000 description 1
- 229960004203 carnitine Drugs 0.000 description 1
- CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 description 1
- 229940044199 carnosine Drugs 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- SVURIXNDRWRAFU-OGMFBOKVSA-N cedrol Chemical compound C1[C@]23[C@H](C)CC[C@H]3C(C)(C)[C@@H]1[C@@](O)(C)CC2 SVURIXNDRWRAFU-OGMFBOKVSA-N 0.000 description 1
- 229940026455 cedrol Drugs 0.000 description 1
- PCROEXHGMUJCDB-UHFFFAOYSA-N cedrol Natural products CC1CCC2C(C)(C)C3CC(C)(O)CC12C3 PCROEXHGMUJCDB-UHFFFAOYSA-N 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- NGHOLYJTSCBCGC-UHFFFAOYSA-N cis-cinnamic acid benzyl ester Natural products C=1C=CC=CC=1C=CC(=O)OCC1=CC=CC=C1 NGHOLYJTSCBCGC-UHFFFAOYSA-N 0.000 description 1
- 229940043350 citral Drugs 0.000 description 1
- 235000000484 citronellol Nutrition 0.000 description 1
- 239000001926 citrus aurantium l. subsp. bergamia wright et arn. oil Substances 0.000 description 1
- 239000001071 citrus reticulata blanco var. mandarin Substances 0.000 description 1
- 229940071160 cocoate Drugs 0.000 description 1
- 235000017471 coenzyme Q10 Nutrition 0.000 description 1
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 1
- 229940110767 coenzyme Q10 Drugs 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000004456 color vision Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000008139 complexing agent Substances 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 229910001431 copper ion Inorganic materials 0.000 description 1
- 229960003624 creatine Drugs 0.000 description 1
- 239000006046 creatine Substances 0.000 description 1
- 229940109239 creatinine Drugs 0.000 description 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000000254 damaging effect Effects 0.000 description 1
- YSRSBDQINUMTIF-UHFFFAOYSA-N decane-1,2-diol Chemical compound CCCCCCCCC(O)CO YSRSBDQINUMTIF-UHFFFAOYSA-N 0.000 description 1
- SQIFACVGCPWBQZ-UHFFFAOYSA-N delta-terpineol Natural products CC(C)(O)C1CCC(=C)CC1 SQIFACVGCPWBQZ-UHFFFAOYSA-N 0.000 description 1
- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 229940116365 diethylhexyl syringylidenemalonate Drugs 0.000 description 1
- 229940120503 dihydroxyacetone Drugs 0.000 description 1
- 229940031569 diisopropyl sebacate Drugs 0.000 description 1
- XFKBBSZEQRFVSL-UHFFFAOYSA-N dipropan-2-yl decanedioate Chemical compound CC(C)OC(=O)CCCCCCCCC(=O)OC(C)C XFKBBSZEQRFVSL-UHFFFAOYSA-N 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- NYNCZOLNVTXTTP-UHFFFAOYSA-N ethyl 2-(1,3-dioxoisoindol-2-yl)acetate Chemical compound C1=CC=C2C(=O)N(CC(=O)OCC)C(=O)C2=C1 NYNCZOLNVTXTTP-UHFFFAOYSA-N 0.000 description 1
- 229960002217 eugenol Drugs 0.000 description 1
- 229940079204 evernia prunastri extract Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229940043259 farnesol Drugs 0.000 description 1
- 229930002886 farnesol Natural products 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 description 1
- WTEVQBCEXWBHNA-JXMROGBWSA-N geranial Chemical compound CC(C)=CCC\C(C)=C\C=O WTEVQBCEXWBHNA-JXMROGBWSA-N 0.000 description 1
- 229940113087 geraniol Drugs 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 239000001927 guaiacum sanctum l. gum oil Substances 0.000 description 1
- 235000019382 gum benzoic Nutrition 0.000 description 1
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 description 1
- WNLRTRBMVRJNCN-UHFFFAOYSA-N hexanedioic acid Natural products OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 1
- FVYXIJYOAGAUQK-UHFFFAOYSA-N honokiol Chemical compound C1=C(CC=C)C(O)=CC=C1C1=CC(CC=C)=CC=C1O FVYXIJYOAGAUQK-UHFFFAOYSA-N 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- WPFVBOQKRVRMJB-UHFFFAOYSA-N hydroxycitronellal Chemical compound O=CCC(C)CCCC(C)(C)O WPFVBOQKRVRMJB-UHFFFAOYSA-N 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 229930013032 isoflavonoid Natural products 0.000 description 1
- 150000003817 isoflavonoid derivatives Chemical class 0.000 description 1
- 235000012891 isoflavonoids Nutrition 0.000 description 1
- SVURIXNDRWRAFU-UHFFFAOYSA-N juniperanol Natural products C1C23C(C)CCC3C(C)(C)C1C(O)(C)CC2 SVURIXNDRWRAFU-UHFFFAOYSA-N 0.000 description 1
- 229940001447 lactate Drugs 0.000 description 1
- 150000003893 lactate salts Chemical class 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000000171 lavandula angustifolia l. flower oil Substances 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 229930007744 linalool Natural products 0.000 description 1
- 235000019136 lipoic acid Nutrition 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- JPTOCTSNXXKSSN-UHFFFAOYSA-N methylheptenone Chemical compound CCCC=CC(=O)CC JPTOCTSNXXKSSN-UHFFFAOYSA-N 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 239000001627 myristica fragrans houtt. fruit oil Substances 0.000 description 1
- WIDNAJNXDPHROL-UHFFFAOYSA-N n-[4-(2,4-dihydroxyphenyl)-1,3-thiazol-2-yl]-2-methylpropanamide Chemical compound S1C(NC(=O)C(C)C)=NC(C=2C(=CC(O)=CC=2)O)=C1 WIDNAJNXDPHROL-UHFFFAOYSA-N 0.000 description 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000005487 naphthalate group Chemical group 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 description 1
- 239000005022 packaging material Substances 0.000 description 1
- 229940101267 panthenol Drugs 0.000 description 1
- 235000020957 pantothenol Nutrition 0.000 description 1
- 239000011619 pantothenol Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
- 229940098888 phenethyl benzoate Drugs 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 231100000760 phototoxic Toxicity 0.000 description 1
- 235000011765 phytoene Nutrition 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 150000004804 polysaccharides Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- RMGVATURDVPNOZ-UHFFFAOYSA-M potassium;hexadecyl hydrogen phosphate Chemical compound [K+].CCCCCCCCCCCCCCCCOP(O)([O-])=O RMGVATURDVPNOZ-UHFFFAOYSA-M 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 229940079889 pyrrolidonecarboxylic acid Drugs 0.000 description 1
- 239000010668 rosemary oil Substances 0.000 description 1
- 229940058206 rosemary oil Drugs 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical class [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- 229940080313 sodium starch Drugs 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 229940116411 terpineol Drugs 0.000 description 1
- 229960002663 thioctic acid Drugs 0.000 description 1
- CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- PJHKBYALYHRYSK-UHFFFAOYSA-N triheptanoin Chemical compound CCCCCCC(=O)OCC(OC(=O)CCCCCC)COC(=O)CCCCCC PJHKBYALYHRYSK-UHFFFAOYSA-N 0.000 description 1
- 229940078561 triheptanoin Drugs 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 238000001429 visible spectrum Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/415—Aminophenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/42—Colour properties
- A61K2800/43—Pigments; Dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Definitions
- the present invention relates to a cosmetic preparation containing 4- (tert-butyl) -4'-methoxydibenzoylmethane and / or (2 - [- 4- (diethylamino) -2-hydroxybenzoyl] hexyl benzoate (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate) and diisostearoyl Polyglyceryl-3-dimer-dilinoleates, a process for the production of color-stable cosmetic preparations containing 4- (tert-butyl) -4'-methoxydibenzoylmethane and / or (2 - [- 4- (diethylamino) -2-hydroxybenzoyl] hexyl benzoate (INCI : Diethylamino Hydroxybenzoyl Hexyl Benzoate), characterized in that the preparation diisostearoyl polyglyceryl-3-dimer-dilinole
- UVA and UVB filters are in the most industrialized countries in the form of positive lists such as Annex 7 of the Cosmetics Ordinance.
- Cosmetic preparations and, in particular, sunscreen preparations usually contain complexing agents, EDTA and its salts (in particular sodium salts) preferably being used. These serve to complex the metal ions such as iron or aluminum ions that are "brought in” by water (as an ingredient in numerous preparations), other ingredients (e.g. color pigments) or the packaging material, as these can destabilize and discolor the preparation.
- complexing agents EDTA and its salts (in particular sodium salts) preferably being used. These serve to complex the metal ions such as iron or aluminum ions that are "brought in” by water (as an ingredient in numerous preparations), other ingredients (e.g. color pigments) or the packaging material, as these can destabilize and discolor the preparation.
- the object was therefore to develop a cosmetic preparation (in particular a sunscreen) that contains as little EDTA as possible and is nonetheless color-stable and insensitive to metal ions.
- a cosmetic preparation containing a) 4- (tert-butyl) -4'-methoxydibenzoylmethane and / or (2 - [- 4- (diethylamino) -2-hydroxybenzoyl] hexyl benzoate (INCI: diethylamino hydroxybenzoyl hexyl) Benzoates) and b) diisostearoyl polyglyceryl-3-dimer-dilinoleates.
- the object is also surprisingly achieved by a process for producing color-stable cosmetic preparations containing 4- (tert-butyl) -4'-methoxydibenzoylmethane and / or (2 - [- 4- (diethylamino) -2-hydroxybenzoyl] hexyl benzoate (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate), characterized in that diisostearoyl polyglyceryl-3-dimer-dilinoleate is added to the preparation.
- the object is surprisingly achieved not least through the use of diisostearoyl polyglyceryl-3-dimer-dilinoleates in cosmetic preparations containing 4- (tert-butyl) -4'-methoxydibenzoylmethane and / or (2 - [- 4- (diethylamino) - 2-hydroxybenzoyl] Hexyl benzoate (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate) to prevent the formation of complexes with metal ions.
- metal ions are understood to mean aluminum, iron and copper ions.
- the preparation is free from 3- (4-methylbenzylidene) camphor, 2-hydroxy-4-methoxybenzophenone (INCI: Oxybenzon), 4-methoxycinnamic acid-2-ethylhexyl ester (INCI: Octylmethoxycinnamate), Parabens (especially methyl, propyl and butyl paraben), methyl isothiazolinone, chloromethyl isothiazolinone and DMDM hydantoin, polyethylene glycol ethers or polyethylene glycol esters.
- Embodiments of the present invention which are advantageous according to the invention are further characterized in that the preparation is free from octocrylene. It is advantageous for the purposes of the present invention if the preparation contains diisostearoyl polyglyceryl-3-dimer-dilinoleates, which is characterized in that it has a viscosity of in a 50% by weight solution in C12-15 alkyl benzoate at 25 ° C has greater than / equal to 1500 mPas. According to the invention, such a solution preferably has a viscosity of greater than / equal to 3000 mPas and particularly preferably a viscosity of greater than / equal to 3400 mPas.
- this measurement can also be carried out in a 50% Caprylic / Capric Triglyceride solution.
- the viscosity is determined according to the invention as follows: All values relate to The measurements are carried out at 25 ° C. in a 150 ml beaded rim glass with the aid of the Rheomat R 123 rotational viscometer from proRheo. Measuring body no.1 (item no. 200 0191) is used as the measuring body. It uses speed range 62.5 min -1. Unless otherwise specified, the viscosity is always measured 24 hours after the mixture has been prepared.
- the preparation contains diisostearoyl polyglyceryl-3-dimer-dilinoleates in a concentration of 0.1 to 5% by weight, based on the total weight of the preparation.
- the preparation contains 4- (tert-butyl) -4'-methoxydibenzoylmethane and no (2 - [- 4- (diethylamino) -2-hydroxybenzoyl] hexyl benzoate (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate), it is advantageous according to the invention if the Preparation 4- (tert-butyl) -4'-methoxydibenzoylmethane in a concentration of 0.1 to 5% by weight, based on the total weight of the preparation, with a concentration of 1 to 5% by weight, based on the total weight of the Preparation is preferred according to the invention.
- the weight ratio of 4- (tert-butyl) -4'-methoxydibenzoylmethane to diisostearoyl polyglyceryl-3-dimer-dilinoleates in the preparation is advantageously 1:50 to 1: 1.
- the preparation contains (2 - [- 4- (Diethylamino) -2-hydroxybenzoyl] benzoic acid hexyl ester (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate) and no 4- (tert-butyl) -4'-methoxydibenzoylmethane, it is advantageous according to the invention if the Preparation contains diethylamino hydroxybenzoyl hexyl benzoate in a concentration of 0.1 to 10% by weight, based on the total weight of the preparation, a concentration of 0.5 to 8% by weight, based on the total weight of the preparation, being preferred according to the invention.
- the weight ratio of diethylamino hydroxybenzoyl hexyl benzoate to diisostearoyl polyglyceryl-3-dimer-dilinoleates in the preparation is advantageously from 1:50 to 2: 1.
- the preparation contains 4- (tert-butyl) -4'-methoxydibenzoylmethane and (2 - [- 4- (diethylamino) -2-hydroxybenzoyl] hexyl benzoate (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate), it is advantageous according to the invention if the preparation 4- (tert-butyl) -4'-methoxydibenzoylmethane in a concentration of 0.1 to 5% by weight, based on the total weight of the preparation, with a concentration of 1 to 5% by weight, based on the total weight of the preparation , is preferred according to the invention.
- Diethylamino Hydroxybenzoyl Hexyl Benzoate is used in this case in a concentration of 0.1 to 10% by weight, based on the total weight of the preparation, a concentration of 1 to 10% by weight, based on the total weight of the preparation, being preferred according to the invention.
- dilinoleates are advantageously 1:25 to 3: 1.
- Embodiments of the present invention which are advantageous according to the invention are characterized in that the preparation contains iron-containing color pigments.
- the following iron-containing color pigments can be used, for example: Unipure Red LC 386, Unipure Brown LC 889, Unipure Brown LC 881, Unipure Yellow LC 188, Unipure Black LC 989, (from Sensient Cosmetic Technologies), BLACK NF (from Kobo Products, Inc.) .
- the preparation according to the invention can be present as an aqueous-alcoholic solution, as an alcoholic solution, as a hydrodispersion, as a W / O emulsion and as an O / W emulsion, the person skilled in the art differentiating the hydrodispersion from the O / W emulsion on the basis of the emulsifier content . It is advantageous according to the invention if the preparation is in the form of an O / W emulsion.
- the preparation has one or more O / W emulsifiers selected from the group of the compounds glyceryl stearate citrate, glyceryl stearate (self-emulsifying), stearic acid, stearate salts, polyglyceryl-3-methylglycose distearate, sodium cetearyl sulfate, potassium cetyl phosphate Contains 10 stearates, sodium stearoyl glutamate.
- O emulsifiers selected from the group of the compounds glyceryl stearate citrate, glyceryl stearate (self-emulsifying), stearic acid, stearate salts, polyglyceryl-3-methylglycose distearate, sodium cetearyl sulfate, potassium cetyl phosphate Contains 10 stearates, sodium stearoyl glutamate.
- Embodiments of the present invention which are advantageous according to the invention are further characterized in that the preparation 2,4-bis - ⁇ [4- (2-ethylhexyloxy) -2-hydroxy] -phenyl ⁇ -6- (4-methoxyphenyl) -1 , 3,5-triazine (INCI bis-ethylhexyloxyphenol methoxyphenyl triazine), 2,4,6-tris- [anilino- (p-carbo-2'-ethyl-1 '-hexyloxy)] - 1,3,5-triazine (INCI: Ethylhexyl Triazone) and / or 2-phenylbenzimidazole-5-sulfonic acid salts.
- the use concentration advantageous according to the invention is from 0.5 to 4.5% by weight based on the total weight of the preparation.
- the advantageous according to the invention is Use concentration 0.5 to 10% by weight based on the total weight of the preparation.
- the use concentration advantageous according to the invention is 0.1 to 3% by weight based on the total weight of the preparation.
- the preparation according to the invention can contain further UV filters. It is advantageous according to the invention if the preparation contains xanthan gum (INCI: Xanthan Gum).
- the embodiments preferred according to the invention are characterized in that the preparation contains xanthan gum (INCI: Xanthan Gum) in a concentration of 0.01 to 1% by weight, based on the total weight of the preparation.
- xanthan gum INCI: Xanthan Gum
- compositions within the meaning of the present invention are characterized in that the preparation contains phenoxyethanol, ethylhexylglycerol and / or 4-hydroxyacetophenone.
- the preparation contains one or more alkanediols from the group of compounds 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-decanediol, 2-methyl-1,3 -propanediol contains.
- Embodiments of the present invention which are advantageous according to the invention are characterized in that the preparation has one or more compounds selected from the group of compounds alpha-lipoic acid, folic acid, phytoene, D-biotin, coenzyme Q10, alpha-glucosyl rutin, carnitine, carnosine, natural and / or synthetic isoflavonoids, flavonoids, creatine, creatinine, taurine, b-alanine, panthenol, magnolol, honokiol, tocopheryl acetate, dihydroxyacetone; Thiamidol; 8-hexadecene-1, 16-dicarboxylic acid, glycerylglycose, (2-hydroxyethyl) urea, vitamin E or its derivatives, hyaluronic acid and / or its salts and / or licochalcone A contains.
- the preparation has one or more compounds selected from the group of compounds alpha-lipoic acid,
- the preparation according to the invention can advantageously contain humectants.
- Moisturizers are substances or mixtures of substances that give cosmetic preparations the property of reducing the release of moisture from the horny layer (also called transepidermal water loss (TEWL)) and / or the hydration of the horny layer after application or distribution on the skin surface to influence positively.
- TEWL transepidermal water loss
- moisturizers for the purposes of the present invention are, for example, glycerol, lactic acid and / or lactates, in particular sodium lactate, butylene glycol, propylene glycol, biosaccaride gum-1, glycine soy, ethylhexyloxyglycerol, pyrrolidone carboxylic acid and urea.
- polymeric moisturizers from the group of to use water-soluble and / or water-swellable and / or water-gellable poly saccharides.
- hyaluronic acid chitosan and / or a fucose-rich polysaccharide
- a fucose-rich polysaccharide which is filed in the Chemical Abstracts under the registry number 178463-23-5 and z. B.
- Fucogel®1000 from SOLABIA SA.
- Moisturizers can also be used advantageously as anti-wrinkle ingredients to protect against skin changes such as those caused by skin changes. B. occur with skin aging, can be used.
- the cosmetic preparations according to the invention can also advantageously, although not necessarily, contain fillers which, for. B. further improve the sensory and cosmetic properties of the formulations and, for example, induce or intensify a velvety or silky feel on the skin.
- Advantageous fillers for the purposes of the present invention are starch and starch derivatives (such as tapioca starch, distarch phosphate, aluminum or sodium starch, octenyl succinate and the like), pigments that have neither a mainly UV filter nor a coloring effect (such as. B. boron nitride etc.) and / or Aerosile ® (CAS No. 7631-86-9) and / or talc and / or polyethylene, nylon.
- the preparation according to the invention contains tapioca starch and / or distarch phosphate.
- Embodiments of the present invention which are advantageous according to the invention are characterized in that the preparation has one or more oils selected from the group of the compounds butylene glycol dicaprylate / dicaprate, phenethyl benzoate, C12-15 alkyl benzoate, dibutyl adipate; Diisopropyl sebacate, dicaprylyl carbonate, di-C12-13 alkyl tartrates, butyloctyl salicylate, diethylhexyl syringylidene malonate, hydrated castor oil dimerate, triheptanoin, C12-13 alkyl lactate, C16-17, alkyl benzoate, propylheptyl caprylate, diethyl hexiglycer 2,6 caprylate - Contains naphthalate, octyldodecanol, caprylic / capric triglyceride, ethylhexyl cocoate.
- oils selected
- the preparation contains dibutyl adipate, dicaprylyl carbonate, butylene glycol dicaprylate / dicaprate and / or C12-C15 alkyl benzoate.
- the water phase of the preparations according to the invention can advantageously contain customary cosmetic auxiliaries, such as, for example, alcohols, in particular those with a low carbon number, preferably ethanol and / or isopropanol or polyols with a low carbon number, and their ethers, preferably propylene glycol, glycerol, electrolytes, self-tanners and, in particular, a or more thickeners, which or which can advantageously be selected from Group silicon dioxide, aluminum silicates, polysaccharides and their derivatives, e.g. B. hyaluronic acid, hydroxypropylmethyl cellulose.
- customary cosmetic auxiliaries such as, for example, alcohols, in particular those with a low carbon number, preferably ethanol and / or isopropanol or polyols with a low carbon number
- ethers preferably propylene glycol, glycerol
- electrolytes preferably propylene glycol, glycerol
- the preparation according to the invention contains perfumes.
- the total concentration of perfumes in the preparation is from 0.00001 to 1% by weight, based on the total weight of the preparation.
- the total concentration of perfumes in the preparation is from 0.00005 to 0.5% by weight, based on the total weight of the preparation.
- the preparation according to the invention has one or more perfumes selected from the group of the compounds limonene, citral, linalool, alpha-isomethylionone, geraniol, citronellol, 2-isobutyl-4-hydroxy-4-methyltetrahydropyran, 2-tert-pentylcyclohexyl acetate, 3-methyl-5-phenyl-1-pentanol, 7-acetyl-1, 1, 3,4,4,6-hexamethyltetralin, adipic acid diester, alpha-amylcinnamaldehyde, alpha-methylionone, amyl C butylphenylmethylpropionalcinnamal, amyl salicylate, Amylcinnamylalkohol, anisyl alcohol, benzoin, benzyl alcohol, benzyl benzoate, benzyl cinnamate, benzyl salicylate,
- preparations according to the invention can contain the ingredients customary for cosmetic sunscreens in the customary use concentrations.
- a spectrophotometer measures spectral data, i.e. the amount of light energy that is reflected from an object at multiple intervals along the visible spectrum. The spectral data are displayed as a spectral curve, which is converted into the tristimulus space (CIEXYZ) by a computational transformation t 1 ⁇ 2 !
- tristimulus values are of limited use as color specifications because they correlate poorly with visual attributes.
- the spectrophotomer was controlled by an HP EliteDesk 800 G1 TWR (Intel ® Core TM i5vPro) computer, which did all color calculations from the digitized spectral data using the Color iQC Professional with SLITaper ® Version 8.3.9 software (X-Rite Incorporated, Michigan, USA). Each time the software was started, the device was properly calibrated with the supplied white and black standard.
- a disposable Petri dish made of polystyrene (35/10 mm) was filled completely to the edge and bubble-free with the filling material to be measured and sealed.
- the completely filled Petri dish was then placed in the Puluz photobox (size: 22 x 23 x 24 cm) for the measurement.
- a photo box (Morza PULUZ) with 20 white integrated LEDs was used.
- the spectrophotometer was placed on the lid of the Petri dish and triggered. A total of 10 random measurements were carried out on the entire surface of the Petri dish for each emulsion.
Abstract
The invention relates to a cosmetic preparation containing a) 4-(tert.-butyl)-4'-methoxydibenzoyl methane and/or (2-[-4-(diethylamino)-2-hydroxybenzoyl] benzoic acid hexyl ester (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate) and b) diisostearoyl polyglyceryl-3-dimer-dilinoleate.
Description
Beiersdorf Aktiengesellschaft Beiersdorf Aktiengesellschaft
Hamburg Hamburg
Beschreibung description
Farbstabiles Sonnenschutzmittel Color stable sunscreen
Die vorliegende Erfindung betrifft eine kosmetische Zubereitung enthaltend 4-(tert.-Butyl)-4’- methoxydibenzoylmethan und/oder (2-[-4-(Diethylamino)-2-hydroxybenzoyl] Benzoesäurehexylester (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate) sowie Diisostearoyl Polyglyceryl-3-Dimer-Dilinoleate, ein Verfahren zur Herstellung farbstabiler kosmetischer Zubereitungen enthaltend 4-(tert.-Butyl)-4’-methoxydibenzoylmethan und/oder (2-[-4- (Diethylamino)-2-hydroxybenzoyl] Benzoesäurehexylester (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate), dadurch gekennzeichnet, dass der Zubereitung Diisostearoyl Polyglyceryl-3- Dimer-Dilinoleate zugesetzt wird und die Verwendung von Diisostearoyl Polyglyceryl-3-Dimer- Dilinoleate in kosmetischen Zubereitungen enthaltend 4-(tert.-Butyl)-4’-methoxydibenzoylmethan und/oder (2-[-4-(Diethylamino)-2-hydroxybenzoyl] Benzoesäurehexylester (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate) zur Verhinderung der Bildung von Komplexen mit Metall-Ionen. The present invention relates to a cosmetic preparation containing 4- (tert-butyl) -4'-methoxydibenzoylmethane and / or (2 - [- 4- (diethylamino) -2-hydroxybenzoyl] hexyl benzoate (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate) and diisostearoyl Polyglyceryl-3-dimer-dilinoleates, a process for the production of color-stable cosmetic preparations containing 4- (tert-butyl) -4'-methoxydibenzoylmethane and / or (2 - [- 4- (diethylamino) -2-hydroxybenzoyl] hexyl benzoate (INCI : Diethylamino Hydroxybenzoyl Hexyl Benzoate), characterized in that the preparation diisostearoyl polyglyceryl-3-dimer-dilinoleate is added and the use of diisostearoyl polyglyceryl-3-dimer-dilinoleates in cosmetic preparations containing 4- (tert-butyl) -4 ' -methoxydibenzoylmethane and / or (2 - [- 4- (Diethylamino) -2-hydroxybenzoyl] benzoic acid hexyl ester (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate) to prevent the formation of complexes with metal ions.
Der Trend weg von der vornehmen Blässe hin zur „gesunden, sportlich braunen Haut“ ist seit Jahren ungebrochen. Um diese zu erzielen setzen die Menschen ihre Haut der Sonnenstrahlung aus, da diese eine Pigmentbildung im Sinne einer Melaninbildung hervorruft. Die ultraviolette Strahlung des Sonnenlichtes hat jedoch auch eine schädigende Wirkung auf die Haut. Neben der akuten Schädigung (Sonnenbrand) treten Langzeitschäden wie ein erhöhtes Risiko an Hautkrebs zu erkranken bei übermäßiger Bestrahlung mit Licht aus dem UVB-Bereich (Wellenlänge: 280-320 nm) auf. Die übermäßige Einwirkung der UVB- und UVA-Strahlung (Wellenlänge: 320-400 nm) führt darüber hinaus zu einer Schwächung der elastischen und kollagenen Fasern des Bindegewebes. Dies führt zu zahlreichen phototoxischen und photoallergischen Reaktionen und hat eine vorzeitige Hautalterung zur Folge. The trend away from elegant paleness towards “healthy, sporty brown skin” has been unbroken for years. In order to achieve this, people expose their skin to solar radiation, as this causes pigment formation in the sense of melanin. However, the ultraviolet radiation of sunlight also has a damaging effect on the skin. In addition to the acute damage (sunburn), long-term damage such as an increased risk of developing skin cancer occurs with excessive exposure to light from the UVB range (wavelength: 280-320 nm). The excessive exposure to UVB and UVA radiation (wavelength: 320-400 nm) also leads to a weakening of the elastic and collagen fibers of the connective tissue. This leads to numerous phototoxic and photoallergic reactions and leads to premature aging of the skin.
Zum Schutz der Haut wurde daher eine Reihe von Lichtschutzfiltersubstanzen entwickelt, die in kosmetischen Zubereitungen eingesetzt werden können. Diese UVA- und UVB-Filter sind in den
meisten Industrieländern in Form von Positivlisten wie dem Anlage 7 der Kosmetikverordnung zusammengefasst. To protect the skin, a number of light protection filter substances have therefore been developed that can be used in cosmetic preparations. These UVA and UVB filters are in the most industrialized countries in the form of positive lists such as Annex 7 of the Cosmetics Ordinance.
Die Vielzahl an kommerziell erhältlichen Sonnenschutzmitteln darf jedoch nicht darüber hinwegtäuschen, dass diese Zubereitungen des Standes der Technik eine Reihe von Nachteilen aufweisen. The large number of commercially available sunscreens should not, however, obscure the fact that these prior art preparations have a number of disadvantages.
Kosmetische Zubereitungen und insbesondere Sonnenschutzzubereitungen enthalten üblicherweise Komplexbildner, wobei vorzugsweise EDTA und deren Salze (insbesondere Natriumsalze) eingesetzt werden. Diese dienen dazu, die durch Wasser (als Inhaltstoff zahlreicher Zubereitungen), weitere Inhaltsstoffe (z.B. Farbpigmente) oder dem Packmittel „eingeschleppten“ Metallionen wie Eisen- oder Aluminium-Ionen zu komplexieren, da diese die Zubereitung destabilisieren und verfärben können. Insbesondere bei Zubereitungen, welche die UV-A-Filter 4- (tert.-Butyl)-4’-methoxydibenzoylmethan und/oder (2-[-4-(Diethylamino)-2-hydroxybenzoyl] Benzoesäurehexylester (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate) enthalten, die rötlich farbige Metallkomplexe bilden, ist ein solcher Zusatz nach dem Stande der Technik zwingend erforderlich, da die Zubereitung sich ansonsten rötlich-braun verfärbt. Diese Effekte werden beispielsweise in der DE 19853288 beschrieben. Cosmetic preparations and, in particular, sunscreen preparations usually contain complexing agents, EDTA and its salts (in particular sodium salts) preferably being used. These serve to complex the metal ions such as iron or aluminum ions that are "brought in" by water (as an ingredient in numerous preparations), other ingredients (e.g. color pigments) or the packaging material, as these can destabilize and discolor the preparation. In particular in the case of preparations which use the UV-A filter 4- (tert-butyl) -4'-methoxydibenzoylmethane and / or (2 - [- 4- (diethylamino) -2-hydroxybenzoyl] benzoic acid hexyl ester (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate ), which form reddish-colored metal complexes, such an addition is absolutely necessary according to the state of the art, since the preparation otherwise turns reddish-brown.These effects are described in DE 19853288, for example.
Nachteilig am Stande der Technik ist nun der Umstand, dass der Einsatz von EDTA und dessen Salzen von einigen Teilnehmern der Fachwelt zunehmend kritisch gesehen wird. Es besteht die Besorgnis, dass diese Verbindung sich nicht schnell genug biologisch abbauen lassen könnte oder dass sie die Hautpenetration fördern könnte. Ob derlei Bedenken begründet sind oder nicht kann im Rahmen der vorliegenden Offenbarung offen und den weiteren Untersuchungen der Fachwelt überlassen bleiben. Tatsache ist jedoch, dass die Verbraucher zunehmend Produkte wünschen, die möglichst wenig und idealerweise kein EDTA enthalten. The disadvantage of the state of the art is the fact that the use of EDTA and its salts is being viewed increasingly critically by some of the experts. There is concern that this compound may not biodegrade quickly enough or that it may promote skin penetration. Whether or not such concerns are justified can be left open within the scope of the present disclosure and left to further investigations by experts. The fact is, however, that consumers are increasingly wanting products that contain as little EDTA as possible, and ideally no.
Es war daher die Aufgabe, eine kosmetische Zubereitung (insbesondere ein Sonnenschutzmittel) zu entwickeln, dass möglichst wenig EDTA enthält und trotzdem farbstabil und unempfindlich gegenüber Metallionen ist. The object was therefore to develop a cosmetic preparation (in particular a sunscreen) that contains as little EDTA as possible and is nonetheless color-stable and insensitive to metal ions.
Überraschend gelöst wird die Aufgabe durch eine kosmetische Zubereitung enthaltend a) 4-(tert.-Butyl)-4’-methoxydibenzoylmethan und/oder (2-[-4-(Diethylamino)-2-hydroxybenzoyl] Benzoesäurehexylester (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate) und b) Diisostearoyl Polyglyceryl-3-Dimer-Dilinoleate.
Überraschend gelöst wird die Aufgabe fernher durch ein Verfahren zur Herstellung farbstabiler kosmetischer Zubereitungen enthaltend 4-(tert.-Butyl)-4’-methoxydibenzoylmethan und/oder (2-[-4- (Diethylamino)-2-hydroxybenzoyl] Benzoesäurehexylester (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate), dadurch gekennzeichnet, dass der Zubereitung Diisostearoyl Polyglyceryl-3- Dimer-Dilinoleate zugesetzt wird. The object is surprisingly achieved by a cosmetic preparation containing a) 4- (tert-butyl) -4'-methoxydibenzoylmethane and / or (2 - [- 4- (diethylamino) -2-hydroxybenzoyl] hexyl benzoate (INCI: diethylamino hydroxybenzoyl hexyl) Benzoates) and b) diisostearoyl polyglyceryl-3-dimer-dilinoleates. The object is also surprisingly achieved by a process for producing color-stable cosmetic preparations containing 4- (tert-butyl) -4'-methoxydibenzoylmethane and / or (2 - [- 4- (diethylamino) -2-hydroxybenzoyl] hexyl benzoate (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate), characterized in that diisostearoyl polyglyceryl-3-dimer-dilinoleate is added to the preparation.
Überraschend gelöst wird die Aufgabe nicht zuletzt durch die Verwendung von Diisostearoyl Polyglyceryl-3-Dimer-Dilinoleate in kosmetischen Zubereitungen enthaltend 4-(tert.-Butyl)-4’- methoxydibenzoylmethan und/oder (2-[-4-(Diethylamino)-2-hydroxybenzoyl] Benzoesäurehexylester (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate) zur Verhinderung der Bildung von Komplexen mit Metall-Ionen. The object is surprisingly achieved not least through the use of diisostearoyl polyglyceryl-3-dimer-dilinoleates in cosmetic preparations containing 4- (tert-butyl) -4'-methoxydibenzoylmethane and / or (2 - [- 4- (diethylamino) - 2-hydroxybenzoyl] Hexyl benzoate (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate) to prevent the formation of complexes with metal ions.
Dabei werden erfindungsgemäß unter Metall-Ionen Aluminium-, Eisen- und Kupfer-Ionen verstanden. According to the invention, metal ions are understood to mean aluminum, iron and copper ions.
Die Formulierungen „erfindungsgemäß“, „erfindungsgemäß vorteilhaft“ etc. beziehen sich im Rahmen der vorliegenden Offenbarung immer auf die erfindungsgemäße kosmetische Zubereitung (Sonnenschutzmittel), die erfindungsgemäßen Verwendungen und das erfindungsgemäße Verfahren, wenn es im Einzelfall nicht anders beschrieben wird. The formulations “according to the invention”, “advantageous according to the invention” etc. always relate in the context of the present disclosure to the cosmetic preparation according to the invention (sunscreen agent), the uses according to the invention and the method according to the invention, unless otherwise described in the individual case.
Zwar kennt der Stand der Technik die DE 102014202377.7, doch konnte diese Schrift nicht den Weg zur vorliegenden Erfindung weisen. Although the prior art knows DE 102014202377.7, this document could not point the way to the present invention.
Es ist erfindungsgemäß vorteilhaft, wenn die Zubereitung frei ist von EDTA. It is advantageous according to the invention if the preparation is free from EDTA.
Darüber hinaus ist es erfindungsgemäß von Vorteil, wenn die Zubereitung frei ist von 3-(4- Methylbenzyliden)-campher, 2-Hydroxy-4-methoxybenzophenon (INCI: Oxybenzon), 4- Methoxyzimtsäure-2-ethylhexylester (INCI: Octylmethoxycinnamate), Parabenen (insbesondere Methyl-, Propyl- und Butylparaben), Methylisothiazolinon, Chlormethyl-isothiazolinon und DMDM- Hydantoin, Polyethylenglycolethern oder Polyethylenglycolestern. In addition, it is advantageous according to the invention if the preparation is free from 3- (4-methylbenzylidene) camphor, 2-hydroxy-4-methoxybenzophenone (INCI: Oxybenzon), 4-methoxycinnamic acid-2-ethylhexyl ester (INCI: Octylmethoxycinnamate), Parabens (especially methyl, propyl and butyl paraben), methyl isothiazolinone, chloromethyl isothiazolinone and DMDM hydantoin, polyethylene glycol ethers or polyethylene glycol esters.
Erfindungsgemäß vorteilhafte Ausführungsformen der vorliegenden Erfindung sind ferner dadurch gekennzeichnet, dass die Zubereitung frei ist von Octocrylen.
Vorteilhaft im Sinne der vorliegenden Erfindung ist es, wenn die Zubereitung Diisostearoyl Polyglyceryl-3-Dimer-Dilinoleate enthält, welches dadurch gekennzeichnet ist, dass es in einer 50 Gew.-%igen Lösung in C12-15 Alkylbenzoat bei 25 °C eine Viskosität von größer/gleich 1500 mPas aufweist. Erfindungsgemäß bevorzugt weist eine solche Lösung eine Viskosität von größer/gleich 3000 mPas und besonders bevorzugt eine Viskosität von größer/gleich 3400 mPas auf. Embodiments of the present invention which are advantageous according to the invention are further characterized in that the preparation is free from octocrylene. It is advantageous for the purposes of the present invention if the preparation contains diisostearoyl polyglyceryl-3-dimer-dilinoleates, which is characterized in that it has a viscosity of in a 50% by weight solution in C12-15 alkyl benzoate at 25 ° C has greater than / equal to 1500 mPas. According to the invention, such a solution preferably has a viscosity of greater than / equal to 3000 mPas and particularly preferably a viscosity of greater than / equal to 3400 mPas.
Alternativ kann diese Messung auch in 50 %iger Caprylic/Capric Triglyceride Lösung vorgenommen werden. Alternatively, this measurement can also be carried out in a 50% Caprylic / Capric Triglyceride solution.
Die Viskosität wird dabei erfindungsgemäß wie folgt bestimmt: Alle Werte beziehen sich auf Die Messungen werden bei 25°C im 150 ml Rollrandglas mit Hilfe des Rotationsviskosimeters Rheomat R 123 der Firma proRheo durchgeführt. Als Messkörper wird der Messkörper Nr.1 (Artikelnr. 200 0191) eingesetzt. Es Drehzahl Bereich 62,5 min-1, verwendet. Erfolgt keine andere Angabe, so erfolgt die Messung zur Viskosität immer 24h nach Herstellung der Mischung. The viscosity is determined according to the invention as follows: All values relate to The measurements are carried out at 25 ° C. in a 150 ml beaded rim glass with the aid of the Rheomat R 123 rotational viscometer from proRheo. Measuring body no.1 (item no. 200 0191) is used as the measuring body. It uses speed range 62.5 min -1. Unless otherwise specified, the viscosity is always measured 24 hours after the mixture has been prepared.
Das Gleiche gilt für alle angegeben Viskositätswerte, welche sich immer auf eine Messung 24h nach Herstellung beziehen, sofern keine andere Zeitangabe angegeben ist. The same applies to all specified viscosity values, which always relate to a measurement 24 hours after production, unless a different time is specified.
Es ist erfindungsgemäß vorteilhaft, wenn die Zubereitung Diisostearoyl Polyglyceryl-3-Dimer- Dilinoleate in einer Konzentration von 0.1 bis 5 Gewichts-%, bezogen auf das Gesamtgewicht der Zubereitung, enthält. Dabei ist eine Konzentration von 0.5 bis 3 Gewichts-%, bezogen auf das Gesamtgewicht der Zubereitung, erfindungsgemäß bevorzugt. It is advantageous according to the invention if the preparation contains diisostearoyl polyglyceryl-3-dimer-dilinoleates in a concentration of 0.1 to 5% by weight, based on the total weight of the preparation. A concentration of 0.5 to 3% by weight, based on the total weight of the preparation, is preferred according to the invention.
Es können drei erfindungsgemäß vorteilhafte Ausführungsformen der vorliegenden Erfindung unterschieden werden: A distinction can be made between three embodiments of the present invention that are advantageous according to the invention:
Enthält die Zubereitung 4-(tert.-Butyl)-4’-methoxydibenzoylmethan und kein (2-[-4-(Diethylamino)-2- hydroxybenzoyl] Benzoesäurehexylester (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate), so ist es erfindungsgemäß vorteilhaft wenn die Zubereitung 4-(tert.-Butyl)-4’-methoxydibenzoylmethan in einer Konzentration von 0.1 bis 5 Gewichts-%, bezogen auf das Gesamtgewicht der Zubereitung, enthält, wobei eine Konzentration von 1 bis 5 Gewichts-%, bezogen auf das Gesamtgewicht der Zubereitung, erfindungsgemäß bevorzugt ist. If the preparation contains 4- (tert-butyl) -4'-methoxydibenzoylmethane and no (2 - [- 4- (diethylamino) -2-hydroxybenzoyl] hexyl benzoate (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate), it is advantageous according to the invention if the Preparation 4- (tert-butyl) -4'-methoxydibenzoylmethane in a concentration of 0.1 to 5% by weight, based on the total weight of the preparation, with a concentration of 1 to 5% by weight, based on the total weight of the Preparation is preferred according to the invention.
Das Gewichtsverhältnis von 4-(tert.-Butyl)-4’-methoxydibenzoylmethan zu Diisostearoyl Polyglyceryl-3-Dimer-Dilinoleate beträgt in der Zubereitung erfindungsgemäß vorteilhaft 1 :50 bis 1 :1.
Enthält die Zubereitung (2-[-4-(Diethylamino)-2-hydroxybenzoyl] Benzoesäurehexylester (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate) und kein 4-(tert.-Butyl)-4’-methoxydibenzoylmethan, so ist es erfindungsgemäß vorteilhaft wenn die Zubereitung Diethylamino Hydroxybenzoyl Hexyl Benzoate in einer Konzentration von 0.1 bis 10 Gewichts-%, bezogen auf das Gesamtgewicht der Zubereitung, enthält, wobei eine Konzentration von 0.5 bis 8 Gewichts-%, bezogen auf das Gesamtgewicht der Zubereitung, erfindungsgemäß bevorzugt ist. According to the invention, the weight ratio of 4- (tert-butyl) -4'-methoxydibenzoylmethane to diisostearoyl polyglyceryl-3-dimer-dilinoleates in the preparation is advantageously 1:50 to 1: 1. If the preparation contains (2 - [- 4- (Diethylamino) -2-hydroxybenzoyl] benzoic acid hexyl ester (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate) and no 4- (tert-butyl) -4'-methoxydibenzoylmethane, it is advantageous according to the invention if the Preparation contains diethylamino hydroxybenzoyl hexyl benzoate in a concentration of 0.1 to 10% by weight, based on the total weight of the preparation, a concentration of 0.5 to 8% by weight, based on the total weight of the preparation, being preferred according to the invention.
Das Gewichtsverhältnis von Diethylamino Hydroxybenzoyl Hexyl Benzoate zu Diisostearoyl Polyglyceryl-3-Dimer-Dilinoleate beträgt in der Zubereitung erfindungsgemäß vorteilhaft ve« 1 :50 bis 2:1. According to the invention, the weight ratio of diethylamino hydroxybenzoyl hexyl benzoate to diisostearoyl polyglyceryl-3-dimer-dilinoleates in the preparation is advantageously from 1:50 to 2: 1.
Enthält die Zubereitung 4-(tert.-Butyl)-4’-methoxydibenzoylmethan und (2-[-4-(Diethylamino)-2- hydroxybenzoyl] Benzoesäurehexylester (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate), so ist es erfindungsgemäß vorteilhaft wenn die Zubereitung 4-(tert.-Butyl)-4’-methoxydibenzoylmethan in einer Konzentration von 0.1 bis 5 Gewichts-%, bezogen auf das Gesamtgewicht der Zubereitung, enthält, wobei eine Konzentration von 1 bis 5 Gewichts-%, bezogen auf das Gesamtgewicht der Zubereitung, erfindungsgemäß bevorzugt ist. If the preparation contains 4- (tert-butyl) -4'-methoxydibenzoylmethane and (2 - [- 4- (diethylamino) -2-hydroxybenzoyl] hexyl benzoate (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate), it is advantageous according to the invention if the preparation 4- (tert-butyl) -4'-methoxydibenzoylmethane in a concentration of 0.1 to 5% by weight, based on the total weight of the preparation, with a concentration of 1 to 5% by weight, based on the total weight of the preparation , is preferred according to the invention.
Diethylamino Hydroxybenzoyl Hexyl Benzoate wird in diesem Falle in einer Konzentration von 0.1 bis 10 Gewichts-%, bezogen auf das Gesamtgewicht der Zubereitung, eingesetzt, wobei eine Konzentration von 1 bis 10 Gewichts-%, bezogen auf das Gesamtgewicht der Zubereitung, erfindungsgemäß bevorzugt ist. Diethylamino Hydroxybenzoyl Hexyl Benzoate is used in this case in a concentration of 0.1 to 10% by weight, based on the total weight of the preparation, a concentration of 1 to 10% by weight, based on the total weight of the preparation, being preferred according to the invention.
Das Gewichtsverhältnis der Gesamtmenge an 4-(tert.-Butyl)-4’-methoxydibenzoylmethan und (2-[- 4-(Diethylamino)-2-hydroxybenzoyl] Benzoesäurehexylester (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate) zu Diisostearoyl Polyglyceryl-3-Dimer-Dilinoleate beträgt erfindungsgemäß vorteilhaft 1 :25 bis 3:1 . The weight ratio of the total amount of 4- (tert-butyl) -4'-methoxydibenzoylmethane and (2 - [- 4- (diethylamino) -2-hydroxybenzoyl] hexyl benzoate (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate) to diisostearoyl polyglyceryl-3-dimer According to the invention, dilinoleates are advantageously 1:25 to 3: 1.
Erfindungsgemäß vorteilhafte Ausführungsformen der vorliegenden Erfindung sind dadurch gekennzeichnet, dass die Zubereitung eisenhaltige Farbpigmente enthält. Embodiments of the present invention which are advantageous according to the invention are characterized in that the preparation contains iron-containing color pigments.
Als eisenhaltige Farbpigmente können beispielsweise eingesetzt werden: Unipure Red LC 386, Unipure Brown LC 889, Unipure Brown LC 881 , Unipure Yellow LC 188, Unipure Black LC 989, (von Sensient Cosmetic Technologies), BLACK NF (von Kobo Products, Inc.).
Die erfindungsgemäße Zubereitung kann als wässrig-alkoholische Lösung, als alkoholische Lösung, als Hydrodispersion, als W/O-Emulsion und als O/W-Emulsion vorliegen, wobei der Fachmann die Hydrodispersion von der O/W-Emulsion anhand des Emulgator-Gehaltes unterscheidet. Erfindungsgemäß vorteilhaft ist es, wenn die Zubereitung in Form einer O/W- Emulsion vorliegt. The following iron-containing color pigments can be used, for example: Unipure Red LC 386, Unipure Brown LC 889, Unipure Brown LC 881, Unipure Yellow LC 188, Unipure Black LC 989, (from Sensient Cosmetic Technologies), BLACK NF (from Kobo Products, Inc.) . The preparation according to the invention can be present as an aqueous-alcoholic solution, as an alcoholic solution, as a hydrodispersion, as a W / O emulsion and as an O / W emulsion, the person skilled in the art differentiating the hydrodispersion from the O / W emulsion on the basis of the emulsifier content . It is advantageous according to the invention if the preparation is in the form of an O / W emulsion.
In einem solchen Falle ist es erfindungsgemäß von Vorteil, wenn die Zubereitung einen oder mehrere O/W-Emulgatoren gewählt aus der Gruppe der Verbindungen Glycerylstearatcitrat, Glycerylstearat (selbstemulgierend), Stearinsäure, Stearatsalze, Polyglyceryl-3- methylglycosedistearat, Natriumcetearylsulfat, Kaliumcetylphosphat, Polyglyceryl-10 Stearate, Natriumstearoylglutamat, enthält. In such a case it is advantageous according to the invention if the preparation has one or more O / W emulsifiers selected from the group of the compounds glyceryl stearate citrate, glyceryl stearate (self-emulsifying), stearic acid, stearate salts, polyglyceryl-3-methylglycose distearate, sodium cetearyl sulfate, potassium cetyl phosphate Contains 10 stearates, sodium stearoyl glutamate.
Erfindungsgemäß vorteilhafte Ausführungsformen der vorliegenden Erfindung sind darüber hinaus dadurch gekennzeichnet, dass die Zubereitung 2,4-Bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6- (4-methoxyphenyl)-1 ,3,5-triazin (INCI Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine), 2,4,6-Tris- [anilino-(p-carbo-2'-ethyl-1 '-hexyloxy)]-1 ,3,5-triazin (INCI: Ethylhexyl Triazone) und/oder 2- Phenylbenzimidazol-5-sulfonsäuresalze enthält. Embodiments of the present invention which are advantageous according to the invention are further characterized in that the preparation 2,4-bis - {[4- (2-ethylhexyloxy) -2-hydroxy] -phenyl} -6- (4-methoxyphenyl) -1 , 3,5-triazine (INCI bis-ethylhexyloxyphenol methoxyphenyl triazine), 2,4,6-tris- [anilino- (p-carbo-2'-ethyl-1 '-hexyloxy)] - 1,3,5-triazine (INCI: Ethylhexyl Triazone) and / or 2-phenylbenzimidazole-5-sulfonic acid salts.
Enthält die Zubereitung 2,4-Bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)- 1 ,3,5-triazin (INCI Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine), so beträgt die erfindungsgemäß vorteilhafte Einsatzkonzentration von 0,5 bis 4,5 Gew.-% bezogen auf das Gesamtgewicht der Zubereitung. If the preparation contains 2,4-bis - {[4- (2-ethyl-hexyloxy) -2-hydroxy] -phenyl} -6- (4-methoxyphenyl) -1, 3,5-triazine (INCI bis-ethylhexyloxyphenol methoxyphenyl Triazines), the use concentration advantageous according to the invention is from 0.5 to 4.5% by weight based on the total weight of the preparation.
Enthält die Zubereitung 2,4,6-Tris-[anilino-(p-carbo-2'-ethyl-1 '-hexyloxy)]-1 ,3,5-triazin (INCI: Ethylhexyl Triazone), so beträgt die erfindungsgemäß vorteilhafte Einsatzkonzentration 0.5 bis 10 Gew.-% bezogen auf das Gesamtgewicht der Zubereitung. If the preparation contains 2,4,6-tris- [anilino- (p-carbo-2'-ethyl-1'-hexyloxy)] - 1,3,5-triazine (INCI: ethylhexyl triazone), the advantageous according to the invention is Use concentration 0.5 to 10% by weight based on the total weight of the preparation.
Enthält die Zubereitung 2-Phenylbenzimidazol-5-sulfonsäuresalze (wobei bevorzugt das Natriumsalz eingesetzt wird), so beträgt die erfindungsgemäß vorteilhafte Einsatzkonzentration 0.1 bis 3 Gew.-% bezogen auf das Gesamtgewicht der Zubereitung. If the preparation contains 2-phenylbenzimidazole-5-sulfonic acid salts (the sodium salt being preferably used), the use concentration advantageous according to the invention is 0.1 to 3% by weight based on the total weight of the preparation.
Darüber hinaus kann die erfindungsgemäße Zubereitung weitere UV-Filter enthalten.
Es ist erfindungsgemäß vorteilhaft, wenn die Zubereitung Xanthangummi (INCI: Xanthan Gum) enthält. In addition, the preparation according to the invention can contain further UV filters. It is advantageous according to the invention if the preparation contains xanthan gum (INCI: Xanthan Gum).
In einem solchen Fall sind die erfindungsgemäß bevorzugten Ausführungsformen dadurch gekennzeichnet, dass die Zubereitung Xanthangummi (INCI: Xanthan Gum) in einer Konzentration 0.01 bis 1 Gew.-%, bezogen auf das Gesamtgewicht der Zubereitung enthält. In such a case, the embodiments preferred according to the invention are characterized in that the preparation contains xanthan gum (INCI: Xanthan Gum) in a concentration of 0.01 to 1% by weight, based on the total weight of the preparation.
Vorteilhafte Ausführungsformen im Sinne der vorliegenden Erfindung sind dadurch gekennzeichnet, dass die Zubereitung Phenoxyethanol, Ethylhexylglycerin und/oder 4- Hydroxyacetophenon enthält. Advantageous embodiments within the meaning of the present invention are characterized in that the preparation contains phenoxyethanol, ethylhexylglycerol and / or 4-hydroxyacetophenone.
Ferner ist es erfindungsgemäß von Vorteil, wenn die Zubereitung ein oder mehrere Alkandiole aus der Gruppe der Verbindungen 1 ,2-Pentandiol, 1 ,2-Hexandiol, 1 ,2-Octandiol, 1 ,2-Decandiol, 2- Methyl-1 ,3-propandiol enthält. It is also advantageous according to the invention if the preparation contains one or more alkanediols from the group of compounds 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-decanediol, 2-methyl-1,3 -propanediol contains.
Erfindungsgemäß vorteilhafte Ausführungsformen der vorliegenden Erfindung sind dadurch gekennzeichnet, dass die Zubereitung eine oder mehrere Verbindungen gewählt aus der Gruppe der Verbindungen alpha-Liponsäure, Folsäure, Phytoen, D-Biotin, Coenzym Q10, alpha- Glucosylrutin, Carnitin, Carnosin, natürliche und/oder synthetische Isoflavonoide, Flavonoide, Kreatin, Kreatinin, Taurin, b-Alanin, Panthenol, Magnolol, Honokiol, Tocopherylacetat, Dihydroxyaceton; Thiamidol; 8-Hexadecen-1 ,16-dicarbonsäure, Glycerylglycose, (2- Hydroxyethyl)harnstoff, Vitamin E bzw. seine Derivate, Hyaluronsäure und/oder deren Salze und/oder Licochalcon A enthält. Embodiments of the present invention which are advantageous according to the invention are characterized in that the preparation has one or more compounds selected from the group of compounds alpha-lipoic acid, folic acid, phytoene, D-biotin, coenzyme Q10, alpha-glucosyl rutin, carnitine, carnosine, natural and / or synthetic isoflavonoids, flavonoids, creatine, creatinine, taurine, b-alanine, panthenol, magnolol, honokiol, tocopheryl acetate, dihydroxyacetone; Thiamidol; 8-hexadecene-1, 16-dicarboxylic acid, glycerylglycose, (2-hydroxyethyl) urea, vitamin E or its derivatives, hyaluronic acid and / or its salts and / or licochalcone A contains.
Die erfindungsgemäße Zubereitung kann vorteilhaft Feuchthaltemittel enthalten. Als Feuchthaltemittel (Moisturizer) werden Stoffe oder Stoffgemische bezeichnet, welche kosmetischen Zubereitungen die Eigenschaft verleihen, nach dem Aufträgen bzw. Verteilen auf der Hautoberfläche die Feuchtigkeitsabgabe der Hornschicht (auch transepidermal water loss (TEWL) genannt) zu reduzieren und/oder die Hydratation der Hornschicht positiv zu beeinflussen. The preparation according to the invention can advantageously contain humectants. Moisturizers are substances or mixtures of substances that give cosmetic preparations the property of reducing the release of moisture from the horny layer (also called transepidermal water loss (TEWL)) and / or the hydration of the horny layer after application or distribution on the skin surface to influence positively.
Vorteilhafte Feuchthaltemittel (Moisturizer) im Sinne der vorliegenden Erfindung sind beispielsweise Glycerin, Milchsäure und/oder Lactate, insbesondere Natriumlactat, Butylenglykol, Propylenglykol, Biosaccaride Gum-1 , Glycine Soja, Ethylhexyloxyglycerin, Pyrrolidoncarbonsäure und Harnstoff. Ferner ist es insbesondere von Vorteil, polymere Moisturizer aus der Gruppe der
wasserlöslichen und/oder in Wasser quellbaren und/oder mit Hilfe von Wasser gelierbaren Poly saccharide zu verwenden. Insbesondere vorteilhaft sind beispielsweise Hyaluronsäure, Chitosan und/oder ein fucosereiches Polysaccharid, welches in den Chemical Abstracts unter der Registraturnummer 178463-23-5 abgelegt und z. B. unter der Bezeichnung Fucogel®1000 von der Gesellschaft SOLABIA S.A. erhältlich ist. Moisturizer können vorteilhaft auch als Antifaltenwirkstoffe zum Schutz vor Hautveränderungen, wie sie z. B. bei der Hautalterung auf- treten, verwendet werden. Advantageous moisturizers for the purposes of the present invention are, for example, glycerol, lactic acid and / or lactates, in particular sodium lactate, butylene glycol, propylene glycol, biosaccaride gum-1, glycine soy, ethylhexyloxyglycerol, pyrrolidone carboxylic acid and urea. Furthermore, it is particularly advantageous to use polymeric moisturizers from the group of to use water-soluble and / or water-swellable and / or water-gellable poly saccharides. For example, hyaluronic acid, chitosan and / or a fucose-rich polysaccharide, which is filed in the Chemical Abstracts under the registry number 178463-23-5 and z. B. is available under the name Fucogel®1000 from SOLABIA SA. Moisturizers can also be used advantageously as anti-wrinkle ingredients to protect against skin changes such as those caused by skin changes. B. occur with skin aging, can be used.
Die erfindungsgemäßen kosmetischen Zubereitungen können ferner vorteilhaft, wenngleich nicht zwingend, Füllstoffe enthalten, welche z. B. die sensorischen und kosmetischen Eigenschaften der Formulierungen weiter verbessern und beispielsweise ein samtiges oder seidiges Hautgefühl hervorrufen oder verstärken. Vorteilhafte Füllstoffe im Sinne der vorliegenden Erfindung sind Stärke und Stärkederivate (wie z. B. Tapiocastärke, Distärkephosphat, Aluminium- bzw. Natrium-Stärke Octenylsuccinat und dergleichen), Pigmente, die weder hauptsächlich UV-Filter- noch färbende Wirkung haben (wie z. B. Bornitrid etc.) und/oder Aerosile® (CAS-Nr. 7631-86-9) und /oder Talkum und/oder Polyethylen, Nylon. The cosmetic preparations according to the invention can also advantageously, although not necessarily, contain fillers which, for. B. further improve the sensory and cosmetic properties of the formulations and, for example, induce or intensify a velvety or silky feel on the skin. Advantageous fillers for the purposes of the present invention are starch and starch derivatives (such as tapioca starch, distarch phosphate, aluminum or sodium starch, octenyl succinate and the like), pigments that have neither a mainly UV filter nor a coloring effect (such as. B. boron nitride etc.) and / or Aerosile ® (CAS No. 7631-86-9) and / or talc and / or polyethylene, nylon.
Es ist erfindungsgemäß bevorzugt, wenn die erfindungsgemäße Zubereitung Tapiocastärke und/oder Distärkephosphat enthält. It is preferred according to the invention if the preparation according to the invention contains tapioca starch and / or distarch phosphate.
Erfindungsgemäß vorteilhafte Ausführungsformen der vorliegenden Erfindung sind dadurch gekennzeichnet, dass die Zubereitung ein oder mehrere Öle gewählt aus der Gruppe der Verbindungen Butylene Glycol Dicaprylat/Dicaprat, Phenethyl Benzoat, C12-15 Alkyl Benzoat, Dibutyladipat; Diisopropylsebacate, Dicaprylylcarbonat, Di-C12-13 Alkyl Tartrate, Butyloctyl Salicylate, Diethylhexyl Syringylidene Malonate, Hydragenated Castor Oil Dimerate, Triheptanoin, C12-13 Alkyl Lactate, C16-17 Alkyl Benzoate, Propylheptyl Caprylate, Caprylic/Capric Triglyceride, Diethylhexyl 2,6-Naphthalate, Octyldodecanol, Caprylic/Capric Triglyceride, Ethylhexyl Cocoate, enthält. Embodiments of the present invention which are advantageous according to the invention are characterized in that the preparation has one or more oils selected from the group of the compounds butylene glycol dicaprylate / dicaprate, phenethyl benzoate, C12-15 alkyl benzoate, dibutyl adipate; Diisopropyl sebacate, dicaprylyl carbonate, di-C12-13 alkyl tartrates, butyloctyl salicylate, diethylhexyl syringylidene malonate, hydrated castor oil dimerate, triheptanoin, C12-13 alkyl lactate, C16-17, alkyl benzoate, propylheptyl caprylate, diethyl hexiglycer 2,6 caprylate - Contains naphthalate, octyldodecanol, caprylic / capric triglyceride, ethylhexyl cocoate.
Dabei ist es erfindungsgemäß bevorzugt, wenn die Zubereitung Dibutyladipat, Dicaprylylcarbonat, Butylene Glycol Dicaprylat/Dicaprat und/oder C12-C15 Alkylbenzoat enthält. It is preferred according to the invention if the preparation contains dibutyl adipate, dicaprylyl carbonate, butylene glycol dicaprylate / dicaprate and / or C12-C15 alkyl benzoate.
Die Wasserphase der erfindungsgemäßen Zubereitungen kann vorteilhaft übliche kosmetische Hilfsstoffe enthalten, wie beispielsweise Alkohole, insbesondere solche niedriger C-Zahl, vorzugsweise Ethanol und/oder Isopropanol oder Polyole niedriger C-Zahl sowie deren Ether, vorzugsweise Propylenglykol, Glycerin, Elektrolyte, Selbstbräuner sowie insbesondere ein oder mehrere Verdickungsmittel, welches oder welche vorteilhaft gewählt werden können aus der
Gruppe Siliciumdioxid, Aluminiumsilikate, Polysaccharide bzw. deren Derivate, z. B. Hyaluronsäu re, Hydroxypropylmethylcellulose. The water phase of the preparations according to the invention can advantageously contain customary cosmetic auxiliaries, such as, for example, alcohols, in particular those with a low carbon number, preferably ethanol and / or isopropanol or polyols with a low carbon number, and their ethers, preferably propylene glycol, glycerol, electrolytes, self-tanners and, in particular, a or more thickeners, which or which can advantageously be selected from Group silicon dioxide, aluminum silicates, polysaccharides and their derivatives, e.g. B. hyaluronic acid, hydroxypropylmethyl cellulose.
Es ist erfindungsgemäß vorteilhaft, wenn die erfindungsgemäße Zubereitung Parfümstoffe enthält.It is advantageous according to the invention if the preparation according to the invention contains perfumes.
Dabei ist es erfindungsgemäß bevorzugt, wenn die Gesamtkonzentration an Parfümstoffen in der Zubereitung von 0,00001 bis 1 Gew.-%, bezogen auf das Gesamtgewicht der Zubereitung, beträgt.It is preferred according to the invention if the total concentration of perfumes in the preparation is from 0.00001 to 1% by weight, based on the total weight of the preparation.
Es ist erfindungsgemäß besonders bevorzugt, wenn die Gesamtkonzentration an Parfümstoffen in der Zubereitung von 0,00005 bis 0,5 Gew.-%, bezogen auf das Gesamtgewicht der Zubereitung, beträgt. It is particularly preferred according to the invention if the total concentration of perfumes in the preparation is from 0.00005 to 0.5% by weight, based on the total weight of the preparation.
Es ist dabei vorteilhaft im Sinne der vorliegenden Erfindung, wenn die erfindungsgemäße Zubereitung einen oder mehrere Parfümstoffe gewählt aus der Gruppe der Verbindungen Limonen, Citral, Linalool, alpha-lsomethylionon, Geraniol, Citronellol, 2-lsobutyl-4-hydroxy-4- methyltetrahydropyran, 2-tert-Pentylcyclohexylacetat, 3-Methyl-5-phenyl-1 -pentanol, 7-Acetyl- 1 ,1 ,3,4,4,6-hexamethyltetralin, Adipinsäurediester, alpha-Amylcinnamaldehyd, Alpha-Methylionon, Amyl C Butylphenylmethylpropionalcinnamal, Amylsalicylat, Amylcinnamylalkohol, Anisalkohol, Benzoin, Benzylalkohol, Benzylbenzoat, Benzylcinnamat, Benzylsalicylat, Bergamotöl, bitteres Orangenöl, Butylphenylmethylpropioal, Cardamomöl, Cedrol, Cinnamal, Cinnamylalkohol, Citronellylmethylcrotonat, Citronenöl, Coumarin, Diethylsuccinat, Ethyllinalool, Eugenol, Evernia Furfuracea Extract, Evernia Prunastri Extract, Farnesol, Guajakholzöl, Hexylcinnamal, Hexylsalicylat, Hydroxycitronellal, Lavendelöl, Lemonenöl, Linaylacetat, Mandarinenöl, Menthyl PCA, Methylheptenon, Muskatnussöl, Rosmarinöl, süßes Orangenöl, Terpineol, Tonkabohnenöl, Triethylcitrat und/oder Vanillin enthält. It is advantageous in the context of the present invention if the preparation according to the invention has one or more perfumes selected from the group of the compounds limonene, citral, linalool, alpha-isomethylionone, geraniol, citronellol, 2-isobutyl-4-hydroxy-4-methyltetrahydropyran, 2-tert-pentylcyclohexyl acetate, 3-methyl-5-phenyl-1-pentanol, 7-acetyl-1, 1, 3,4,4,6-hexamethyltetralin, adipic acid diester, alpha-amylcinnamaldehyde, alpha-methylionone, amyl C butylphenylmethylpropionalcinnamal, amyl salicylate, Amylcinnamylalkohol, anisyl alcohol, benzoin, benzyl alcohol, benzyl benzoate, benzyl cinnamate, benzyl salicylate, bergamot oil, bitter orange oil, Butylphenylmethylpropioal, Cardamom oil, cedrol, cinnamal, cinnamyl alcohol, Citronellylmethylcrotonat, lemon oil, coumarin, diethyl succinate, ethyl linalool, eugenol, Evernia Furfuracea Extract, Evernia Prunastri Extract , Farnesol, Guaiac Wood Oil, Hexylcinnamal, Hexyl Salicylate, Hydroxycitronellal, Lavender Oil, Lemon Oil, Linaylacetate, Mandarin Oil , Menthyl PCA, methylheptenone, nutmeg oil, rosemary oil, sweet orange oil, terpineol, tonka bean oil, triethyl citrate and / or vanillin.
Darüber hinaus können die erfindungsgemäßen Zubereitungen, die für kosmetische Sonnenschutzmittel üblichen Inhaltsstoffe in den üblichen Einsatzkonzentrationen enthalten.
In addition, the preparations according to the invention can contain the ingredients customary for cosmetic sunscreens in the customary use concentrations.
Vergleichsversuch Comparative experiment
Es wurden die folgenden Zubereitungen hergestellt und ihre Farbstabilität verglichen
The following preparations were made and their color stability was compared
1) Fettphase auf 75°C erhitzen, bis alle Komponenten aufgeschmolzen sind. 1) Heat the fat phase to 75 ° C until all components have melted.
2) Anschließend den Verdicker hinzugeben und gründlich vermengen. 2) Then add the thickener and mix thoroughly.
3) Die vorbereitete Wasserphase 10 Minuten rühren, bevor diese weiterverarbeitet wird. 3) Stir the prepared water phase for 10 minutes before processing it further.
4) Die Wasserphase (25°C) unter Rühren zur warmen Fettphase (75°C) geben und für 2-5 Minuten glattrühren. 4) Add the water phase (25 ° C) to the warm fat phase (75 ° C) while stirring and stir until smooth for 2-5 minutes.
5) Einmal homogenisieren 5) Homogenize once
6) Nach dem homogenisieren wird bei Raumtemperatur die Alkoholphase hinzugegeben. 6) After the homogenization, the alcohol phase is added at room temperature.
7) Sobald alle Komponenten homogen verteilt sind, wird ein zweites Mal homogenisiert7) As soon as all components are homogeneously distributed, homogenization is carried out a second time
8) Zum Schluss 5 Minuten nachrühren. 8) Finally stir for 5 minutes.
9) Die Proben wurden anhand des CIELAB Color Systems innerhalb von 48 Stunden vermessen (siehe unten).
CIELAB Color System 9) The samples were measured within 48 hours using the CIELAB Color System (see below). CIELAB Color System
Zur Ermittlung der Farbänderung der Emulsionen wurden der CIELAB oder CIE (L*a*b*) Farbraum und ein tragbares Spektralphotometer SP62 der Firma X-Rite Incorporated (Michigan, USA) benutzt. Ein Spektralphotometer misst Spektraldaten, also die Menge an Lichtenergie, die von einem Objekt in mehreren Intervallen entlang des sichtbaren Spektrums reflektiert wird. Die Spektraldaten werden als Spektralkurve dargestellt, welche durch eine rechnerische Transformation in den Tristimulusraum (CIEXYZ) überführt werden t1·2! Dennoch sind Tristimuluswerte nur begrenzt als Farbspezifikationen verwendbar, da sie schlecht mit visuellen Attributen korrelieren. Da die CIELAB Farbraummessung die menschliche Farbempfindung besser beschreibt [3], wurde diese Methode zur Evaluierung der vorliegenden Fragestellung gewählt. Wenn eine Farbe im CIELAB ausgedrückt wird, definiert L* die Helligkeit, a* bezeichnet den Rot/Grün- Wert und b* den Gelb/Blau-Wert. [1 2] The CIELAB or CIE (L * a * b * ) color space and a portable SP62 spectrophotometer from X-Rite Incorporated (Michigan, USA) were used to determine the change in color of the emulsions. A spectrophotometer measures spectral data, i.e. the amount of light energy that is reflected from an object at multiple intervals along the visible spectrum. The spectral data are displayed as a spectral curve, which is converted into the tristimulus space (CIEXYZ) by a computational transformation t 1 · 2 ! However, tristimulus values are of limited use as color specifications because they correlate poorly with visual attributes. Since the CIELAB color space measurement describes the human color perception better [3] , this method was chosen to evaluate the question at hand. When a color is expressed in CIELAB, L * defines the lightness, a * denotes the red / green value and b * the yellow / blue value. [1 2]
Das Spektralphotomer wurde von einem HP EliteDesk 800 G1 TWR (Intel® Core™ i5vPro)-Rechner gesteuert, der alle Farbberechnungen aus den digitalisierten Spektraldaten mit Hilfe der Software Color iQC Professional with SLITaper® Version 8.3.9 (X-Rite Incorporated, Michigan, USA) durchgeführt. Bei jedem Start der Software wurde das Gerät ordnungsgemäß mit dem gelieferten Weiß- und Schwarzstandard kalibriert. The spectrophotomer was controlled by an HP EliteDesk 800 G1 TWR (Intel ® Core ™ i5vPro) computer, which did all color calculations from the digitized spectral data using the Color iQC Professional with SLITaper ® Version 8.3.9 software (X-Rite Incorporated, Michigan, USA). Each time the software was started, the device was properly calibrated with the supplied white and black standard.
Sowohl die Vorbereitung als auch die Messung aller Proben fand in einem Klimaraum (22 ± 1 ; 55 ± 5 % rel. Luftfeuchtigkeit) statt. Zunächst wurden die Proben wie folgt zubereitet: Both the preparation and the measurement of all samples took place in a climatic room (22 ± 1; 55 ± 5% rel. Humidity). First, the samples were prepared as follows:
Eine Einweg-Petrischale aus Polystyrol (35/10 mm) wurde vollständig bis zum Rand und blasenfrei mit dem zumessenden Füllgut befüllt und verschlossen. Anschließend wurde die vollständig aufgefüllte Petrischale für die Messung in die Puluz-Photobox (Größe:22 x 23 x 24 cm) platziert.A disposable Petri dish made of polystyrene (35/10 mm) was filled completely to the edge and bubble-free with the filling material to be measured and sealed. The completely filled Petri dish was then placed in the Puluz photobox (size: 22 x 23 x 24 cm) for the measurement.
Um zu gewährleisten, dass alle Proben unter den gleichen standarisierten Lichtbedingungen gemessen werden, wurde eine Photobox (Morza PULUZ) mit 20 weißen integrierten LEDs benutzt. Für die Messung wurde das Spektralphotometer auf die Deckel der Petrischale gelegt und ausgelöst. Insgesamt wurden je Emulsion 10 aleatorische Messungen auf der gesamten Oberfläche der Petrischale durchgeführt. To ensure that all samples are measured under the same standardized light conditions, a photo box (Morza PULUZ) with 20 white integrated LEDs was used. For the measurement, the spectrophotometer was placed on the lid of the Petri dish and triggered. A total of 10 random measurements were carried out on the entire surface of the Petri dish for each emulsion.
Der bedeutende Vorteil vom CIELAB-Raum ist, dass er die Bereitstellung eines Mittels zur Messung der Unterschiede zwischen zwei beliebigen Farben darstellt. Ihre Farbdifferenz (DE) wird als Euklidischer Abstand der L*a*b*-Werte anhand der nachfolgenden Formel (1) berechnet, und sollte so klein wie möglich gehalten werden: ^
The major advantage of the CIELAB room is that it provides a means of measuring the differences between any two colors. Your color difference (DE) is calculated as the Euclidean distance of the L * a * b * values using the following formula (1), and should be kept as small as possible: ^
Literaturnachweise Bibliography
1. Sharma, G. and Bala, R. (2017) Digital Color Imaging Handbook 1. Sharma, G. and Bala, R. (2017) Digital Color Imaging Handbook
2. X-Rite, I. A Guide to Understanding Color [Online]. Available at https://www.xrite.com/- /media/xrite/files/whitepaper_pdfs/l10-001 _a_guide_to_understanding_color_communication/l10- 001_understand_color_en.pdf 2. X-Rite, I. A Guide to Understanding Color [Online]. Available at https://www.xrite.com/- / media / xrite / files / whitepaper_pdfs / l10-001 _a_guide_to_understanding_color_communication / l10- 001_understand_color_en.pdf
3. Weatherall, I. L. and Coombs, B. D. (1992) Skin color measurements in terms of CIELAB color space values, The Journal of investigative dermatology, vol. 99, no. 4 3. Weatherall, I. L. and Coombs, B. D. (1992) Skin color measurements in terms of CIELAB color space values, The Journal of investigative dermatology, vol. 99, no.4
4. The BabelColor Company and Pascale, D. (2003 J A comparison of four multimedia RGB spaces
Beispiele 4. The BabelColor Company and Pascale, D. (2003 JA comparison of four multimedia RGB spaces Examples
Die nachfolgenden Beispiele sollen die vorliegende Erfindung verdeutlichen, ohne sie einzu schränken. Alle Mengenangaben, Anteile und Prozentanteile sind, soweit nicht anders angegeben, auf das Gewicht und die Gesamtmenge bzw. auf das Gesamtgewicht der Zubereitungen bezogen.
The following examples are intended to illustrate the present invention without restricting it. Unless otherwise stated, all amounts, proportions and percentages are based on the weight and the total amount or on the total weight of the preparations.
Claims
1 . Kosmetische Zubereitung enthaltend a) 4-(tert.-Butyl)-4’-methoxydibenzoylmethan und/oder (2-[-4-(Diethylamino)-2- hydroxybenzoyl] Benzoesäurehexylester (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate) und b) Diisostearoyl Polyglyceryl-3-Dimer-Dilinoleate. 1 . Cosmetic preparation containing a) 4- (tert-butyl) -4'-methoxydibenzoylmethane and / or (2 - [- 4- (diethylamino) -2-hydroxybenzoyl] hexyl benzoate (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate) and b) diisostearoyl polyglyceryl -3-dimer-dilinoleates.
2. Verfahren zur Herstellung farbstabiler kosmetischer Zubereitungen enthaltend 4-(tert.- Butyl)-4’-methoxydibenzoylmethan und/oder (2-[-4-(Diethylamino)-2-hydroxybenzoyl] Benzoesäurehexylester (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate), dadurch gekennzeichnet, dass der Zubereitung Diisostearoyl Polyglyceryl-3-Dimer-Dilinoleate zugesetzt wird. 2. Process for the production of color-stable cosmetic preparations containing 4- (tert-butyl) -4'-methoxydibenzoylmethane and / or (2 - [- 4- (diethylamino) -2-hydroxybenzoyl] benzoic acid hexyl ester (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate), characterized in that diisostearoyl polyglyceryl-3-dimer-dilinoleate is added to the preparation.
3. Verwendung von Diisostearoyl Polyglyceryl-3-Dimer-Dilinoleate in kosmetischen Zubereitungen enthaltend 4-(tert.-Butyl)-4’-methoxydibenzoylmethan und/oder (2-[-4- (Diethylamino)-2-hydroxybenzoyl] Benzoesäurehexylester (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate) zur Verhinderung der Bildung von Komplexen mit Metall- Ionen. 3. Use of diisostearoyl polyglyceryl-3-dimer-dilinoleates in cosmetic preparations containing 4- (tert-butyl) -4'-methoxydibenzoylmethane and / or (2 - [- 4- (diethylamino) -2-hydroxybenzoyl] hexyl benzoate (INCI : Diethylamino Hydroxybenzoyl Hexyl Benzoate) to prevent the formation of complexes with metal ions.
4. Kosmetische Zubereitung nach Anspruch 1 , Verfahren nach Anspruch 2 oder Verwendung nach Anspruch 3, dadurch gekennzeichnet, dass die Zubereitung frei ist von EDTA. 4. Cosmetic preparation according to claim 1, method according to claim 2 or use according to claim 3, characterized in that the preparation is free from EDTA.
5. Kosmetische Zubereitung, Verfahren oder Verwendung nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass die Zubereitung frei ist von 3-(4- Methylbenzyliden)-campher, 2-Hydroxy-4-methoxybenzophenon (INCI: Oxybenzon), 4- Methoxyzimtsäure-2-ethylhexylester (INCI Octylmethoxycinnamate), Parabenen (insbesondere Methyl-, Propyl- und Butylparaben), Methylisothiazolinon, Chlormethyl- isothiazolinon und DMDM-Hydantoin, Polyethylenglycolethern oder Polyethylenglycolestern. 5. Cosmetic preparation, method or use according to one of the preceding claims, characterized in that the preparation is free from 3- (4- methylbenzylidene) camphor, 2-hydroxy-4-methoxybenzophenone (INCI: Oxybenzone), 4- methoxycinnamic acid 2-ethylhexyl ester (INCI Octylmethoxycinnamate), parabens (especially methyl, propyl and butyl paraben), methyl isothiazolinone, chloromethyl isothiazolinone and DMDM hydantoin, polyethylene glycol ethers or polyethylene glycol esters.
6. Kosmetische Zubereitung, Verfahren oder Verwendung nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass die Zubereitung frei ist von Octocrylen. 6. Cosmetic preparation, method or use according to one of the preceding claims, characterized in that the preparation is free from octocrylene.
7. Kosmetische Zubereitung, Verfahren oder Verwendung nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass die Zubereitung Diisostearoyl Polyglyceryl-3- Dimer-Dilinoleate enthält, welches dadurch gekennzeichnet ist, dass es in einer 50 Gew.- %igen Lösung in C12-15 Alkylbenzoat bei 25 °C eine Viskosität von größer/gleich 1500 mPas aufweist. 7. Cosmetic preparation, method or use according to one of the preceding claims, characterized in that the preparation contains diisostearoyl polyglyceryl-3-dimer dilinoleates, which is characterized in that it is in a 50% by weight solution in C12-15 Alkyl benzoate has a viscosity of greater than / equal to 1500 mPas at 25 ° C.
8. Kosmetische Zubereitung, Verfahren oder Verwendung nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass die Zubereitung Diisostearoyl Polyglyceryl-3-
Dimer-Dilinoleate in einer Konzentration von 0,1 bis 5 Gewichts-%, bezogen auf das Gesamtgewicht der Zubereitung, enthält. 8. Cosmetic preparation, method or use according to one of the preceding claims, characterized in that the preparation diisostearoyl polyglyceryl-3- Contains dimer dilinoleates in a concentration of 0.1 to 5% by weight, based on the total weight of the preparation.
9. Kosmetische Zubereitung, Verfahren oder Verwendung nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass die Zubereitung eisenhaltige Farbpigmente enthält. 9. Cosmetic preparation, method or use according to one of the preceding claims, characterized in that the preparation contains iron-containing color pigments.
10. Kosmetische Zubereitung, Verfahren oder Verwendung nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass die Zubereitung in Form einer O/W-Emulsion vorliegt. 10. Cosmetic preparation, method or use according to one of the preceding claims, characterized in that the preparation is in the form of an O / W emulsion.
11 . Kosmetische Zubereitung, Verfahren oder Verwendung nach Anspruch 10, dadurch gekennzeichnet, dass die Zubereitung einen oder mehrere O/W-Emulgatoren gewählt aus der Gruppe der Verbindungen Glycerylstearatcitrat, Glycerylstearat (selbstemulgierend), Stearinsäure, Stearatsalze, Polyglyceryl-3-methylglycosedistearat, Natriumcetearylsulfat, Kaliumcetylphosphat, Polyglyceryl-10 Stearate, Natriumstearoylglutamat, enthält. 11. Cosmetic preparation, method or use according to claim 10, characterized in that the preparation has one or more O / W emulsifiers selected from the group of the compounds glyceryl stearate citrate, glyceryl stearate (self-emulsifying), stearic acid, stearate salts, polyglyceryl-3-methylglycose distearate, sodium cetearyl cetyl sulfate, potassium cetearyl sulfate , Polyglyceryl-10 stearate, sodium stearoyl glutamate.
12. Kosmetische Zubereitung, Verfahren oder Verwendung nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass die Zubereitung 2,4-Bis-{[4-(2-ethyl-hexyloxy)-2- hydroxy]-phenyl}-6-(4-methoxyphenyl)-1 ,3,5-triazin (INCI Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine), 2,4,6-Tris-[anilino-(p-carbo-2'-ethyl-1 '-hexyloxy)]-1 ,3,5-triazin (INCI: Ethylhexyl Triazone) und/oder 2-Phenylbenzimidazol-5-sulfonsäuresalze enthält.12. Cosmetic preparation, method or use according to one of the preceding claims, characterized in that the preparation 2,4-bis - {[4- (2-ethyl-hexyloxy) -2-hydroxy] -phenyl} -6- (4th -methoxyphenyl) -1, 3,5-triazine (INCI bis-ethylhexyloxyphenol methoxyphenyl triazine), 2,4,6-tris- [anilino- (p-carbo-2'-ethyl-1 '-hexyloxy)] - 1, 3,5-triazine (INCI: Ethylhexyl Triazone) and / or 2-phenylbenzimidazole-5-sulfonic acid salts.
13. Kosmetische Zubereitung, Verfahren oder Verwendung nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass die Zubereitung 4-(tert.-Butyl)-4’-methoxydiben- zoylmethan und kein (2-[-4-(Diethylamino)-2-hydroxybenzoyl] Benzoesäurehexylester (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate) enthält und das Gewichtsverhältnis von 4- (tert.-Butyl)-4’-methoxydibenzoylmethan zu Diisostearoyl Polyglyceryl-3-Dimer-Dilinoleate in der Zubereitung von 1 :50 bis 1 :1 beträgt. 13. Cosmetic preparation, method or use according to one of the preceding claims, characterized in that the preparation 4- (tert-butyl) -4'-methoxydiben- zoylmethane and no (2 - [- 4- (diethylamino) -2- hydroxybenzoyl] benzoic acid hexyl ester (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate) and the weight ratio of 4- (tert-butyl) -4'-methoxydibenzoylmethane to diisostearoyl polyglyceryl-3-dimer-dilinoleate in the preparation is from 1:50 to 1: 1 .
14. Kosmetische Zubereitung, Verfahren oder Verwendung nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass die Zubereitung (2-[-4-(Diethylamino)-2- hydroxybenzoyl] Benzoesäurehexylester (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate) und kein 4-(tert.-Butyl)-4’-methoxydibenzoylmethan enthält und das Gewichtsverhältnis von Diethylamino Hydroxybenzoyl Hexyl Benzoate zu Diisostearoyl Polyglyceryl-3-Dimer-Dilinoleate in der Zubereitung 1 :50 bis 2:1 beträgt. 14. Cosmetic preparation, method or use according to one of the preceding claims, characterized in that the preparation (2 - [- 4- (diethylamino) -2- hydroxybenzoyl] benzoic acid hexyl ester (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate) and no 4- (tert .-Butyl) -4'-methoxydibenzoylmethane and the weight ratio of diethylamino hydroxybenzoyl hexyl benzoate to diisostearoyl polyglyceryl 3-dimer dilinoleates in the preparation is 1:50 to 2: 1.
15. Kosmetische Zubereitung, Verfahren oder Verwendung nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass das Gewichtsverhältnis der Gesamtmenge an 4-(tert.-Butyl)-4’-methoxydibenzoylmethan und (2-[-4-(Diethylamino)-2-hydroxybenzoyl] Benzoesäurehexylester (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate) zu Diisostearoyl Polyglyceryl-3-Dimer-Dilinoleate.von 1 :25 bis 3:1 beträgt.
15. Cosmetic preparation, method or use according to one of the preceding claims, characterized in that the weight ratio of the total amount of 4- (tert-butyl) -4'-methoxydibenzoylmethane and (2 - [- 4- (diethylamino) -2- hydroxybenzoyl] hexyl benzoate (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate) to diisostearoyl polyglyceryl-3-dimer-dilinoleate. from 1:25 to 3: 1.
16. Kosmetische Zubereitung, Verfahren oder Verwendung nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass die Zubereitung Parfümstoffe enthält.
16. Cosmetic preparation, method or use according to one of the preceding claims, characterized in that the preparation contains perfume substances.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102020205042.2A DE102020205042A1 (en) | 2020-04-21 | 2020-04-21 | Color stable sunscreen |
| PCT/EP2021/057288 WO2021213749A1 (en) | 2020-04-21 | 2021-03-22 | Color-stable sunscreen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP4138769A1 true EP4138769A1 (en) | 2023-03-01 |
Family
ID=75267491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP21714852.7A Pending EP4138769A1 (en) | 2020-04-21 | 2021-03-22 | Color-stable sunscreen |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20230233427A1 (en) |
| EP (1) | EP4138769A1 (en) |
| DE (1) | DE102020205042A1 (en) |
| WO (1) | WO2021213749A1 (en) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3913875B2 (en) * | 1998-01-07 | 2007-05-09 | 日本メナード化粧品株式会社 | Cosmetics |
| DE19853288A1 (en) | 1998-11-19 | 2000-05-25 | Beiersdorf Ag | Aluminum complexes of dibenzoylmethane derivatives and cosmetic or dermatological preparations containing them |
| DE10003786A1 (en) * | 2000-01-28 | 2001-08-02 | Merck Patent Gmbh | Galenic formulation |
| DE102014202377A1 (en) | 2014-02-10 | 2015-08-13 | Beiersdorf Ag | Stable cosmetic hydrodispersion |
| DE102018217130A1 (en) * | 2018-10-08 | 2020-04-09 | Beiersdorf Ag | Sunscreen with a combination of waxes and cetyl palmitate |
-
2020
- 2020-04-21 DE DE102020205042.2A patent/DE102020205042A1/en not_active Withdrawn
-
2021
- 2021-03-22 WO PCT/EP2021/057288 patent/WO2021213749A1/en unknown
- 2021-03-22 EP EP21714852.7A patent/EP4138769A1/en active Pending
- 2021-03-22 US US17/996,641 patent/US20230233427A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE102020205042A1 (en) | 2021-10-21 |
| WO2021213749A1 (en) | 2021-10-28 |
| US20230233427A1 (en) | 2023-07-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3093006B1 (en) | Alcohol containing sunscreen product without octocrylene | |
| EP3093007B1 (en) | Octocrylene-free sunscreen comprising diethylamino hydroxybenzoyl hexyl benzoate | |
| EP3093009B1 (en) | Octocrylene-free sunscreen agent with diethylaminohydroxybenzoylhexylbenzoate | |
| EP3173129A1 (en) | Sunscreen comprising titanium dioxide and ethylhexyl salicylate | |
| EP3863597A1 (en) | Sunscreen with a combination of waxes and cetyl palmitate | |
| EP3366352B1 (en) | Waterproof, sprayable sun protection agent | |
| WO2021239478A1 (en) | Sunscreen with a combination of waxes, cetyl palmitate and hydrogenated rapeseed oil | |
| WO2021099090A1 (en) | Novel sunscreen composition containing silica for protection against blue light | |
| EP3437625B1 (en) | Spherical silicates in cosmetic preparations | |
| WO2021213760A1 (en) | Environmentally friendly sunscreen | |
| EP4138772A1 (en) | Environmentally friendly cosmetic sunscreen | |
| WO2021213749A1 (en) | Color-stable sunscreen | |
| EP3746183B1 (en) | O/w emulsion comprising photochemically stable 4-(tert.-butyl)-4'-methoxydibenzoylmethane in oil droplets smaller than 8 micrometers | |
| EP4037639A1 (en) | Bismuth oxychloride-containing sunscreen for protection from blue light | |
| WO2021160366A1 (en) | Polyacrylate-free cosmetic preparation | |
| DE102017202192A1 (en) | Polymer concentrate for sunscreen | |
| DE102022203499A1 (en) | Sunscreen with disodium phenyldibenzimidazole tetrasulfonate | |
| WO2020088905A1 (en) | Cosmetic oil-in-water emulsion containing zinc oxide | |
| EP3846770A1 (en) | Sand-repellent cosmetic preparations | |
| EP3600564B1 (en) | Sunscreen containing polyglyceryl-10 stearate and citronellol | |
| WO2021099089A1 (en) | Sunscreen composition containing silica for protection from blue light | |
| EP4157213A1 (en) | Sunscreen with a combination of carnauba wax and hydrogenated rapeseed oil | |
| WO2021110341A1 (en) | Water-resistant cosmetic sunscreen | |
| DE102019215113A1 (en) | New sunscreen containing bismuth oxychloride to protect against blue light |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: UNKNOWN |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
| 17P | Request for examination filed |
Effective date: 20221121 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
| DAV | Request for validation of the european patent (deleted) | ||
| DAX | Request for extension of the european patent (deleted) | ||
| RAP3 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: BEIERSDORF AG |