EP4128376A1 - Pompe comportant des polymères électroactifs - Google Patents

Pompe comportant des polymères électroactifs

Info

Publication number
EP4128376A1
EP4128376A1 EP21716971.3A EP21716971A EP4128376A1 EP 4128376 A1 EP4128376 A1 EP 4128376A1 EP 21716971 A EP21716971 A EP 21716971A EP 4128376 A1 EP4128376 A1 EP 4128376A1
Authority
EP
European Patent Office
Prior art keywords
pump
electroactive polymer
pumps
blood treatment
pump according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21716971.3A
Other languages
German (de)
English (en)
Inventor
Stephanie Appel
Tobias Stöckerl
David HANNES
Gerome FISCHER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fresenius Medical Care Deutschland GmbH
Original Assignee
Fresenius Medical Care Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fresenius Medical Care Deutschland GmbH filed Critical Fresenius Medical Care Deutschland GmbH
Publication of EP4128376A1 publication Critical patent/EP4128376A1/fr
Pending legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02N—ELECTRIC MACHINES NOT OTHERWISE PROVIDED FOR
    • H02N2/00—Electric machines in general using piezoelectric effect, electrostriction or magnetostriction
    • H02N2/02—Electric machines in general using piezoelectric effect, electrostriction or magnetostriction producing linear motion, e.g. actuators; Linear positioners ; Linear motors
    • H02N2/04—Constructional details
    • H02N2/043—Mechanical transmission means, e.g. for stroke amplification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
    • F04B19/20—Other positive-displacement pumps
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10N—ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10N30/00—Piezoelectric or electrostrictive devices
    • H10N30/50—Piezoelectric or electrostrictive devices having a stacked or multilayer structure
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10N—ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10N30/00—Piezoelectric or electrostrictive devices
    • H10N30/80—Constructional details
    • H10N30/85—Piezoelectric or electrostrictive active materials
    • H10N30/857—Macromolecular compositions
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F05—INDEXING SCHEMES RELATING TO ENGINES OR PUMPS IN VARIOUS SUBCLASSES OF CLASSES F01-F04
    • F05C—INDEXING SCHEME RELATING TO MATERIALS, MATERIAL PROPERTIES OR MATERIAL CHARACTERISTICS FOR MACHINES, ENGINES OR PUMPS OTHER THAN NON-POSITIVE-DISPLACEMENT MACHINES OR ENGINES
    • F05C2231/00—Organic materials not otherwise provided for
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F05—INDEXING SCHEMES RELATING TO ENGINES OR PUMPS IN VARIOUS SUBCLASSES OF CLASSES F01-F04
    • F05C—INDEXING SCHEME RELATING TO MATERIALS, MATERIAL PROPERTIES OR MATERIAL CHARACTERISTICS FOR MACHINES, ENGINES OR PUMPS OTHER THAN NON-POSITIVE-DISPLACEMENT MACHINES OR ENGINES
    • F05C2251/00—Material properties
    • F05C2251/08—Shape memory

Definitions

  • the present invention relates to a pump with a pump actuator having at least one electroactive polymer, the at least one electroactive polymer being arranged such that the at least one electroactive polymer is deformed along the direction of the pump stroke of the pump.
  • the present invention also relates to a blood treatment machine with a pump of this type.
  • a pump according to the invention can be used as part of a pressure holding test.
  • the required solutions are produced from concentrates while the treatment is running and are diluted as required. Pumps are used here to add the required amount of concentrate to the dialysis water provided.
  • the present invention is based on the object of alleviating or even eliminating the problems known from the prior art.
  • the invention is based on the object to provide a particularly accurate pump be.
  • Another aspect of the invention relates to a metering unit and a blood treatment machine with a pump according to the invention.
  • a pump according to the invention is equipped with a pump actuator having at least one electroactive polymer, the at least one electroactive polymer being arranged such that the at least one electroactive polymer is deformed along the direction of the pump stroke of the pump.
  • the deformation / linear expansion of the electroactive polymer takes place along the direction of the pumping movement / the pump stroke of the pump.
  • the size of an executed pump stroke can thus be derived particularly clearly and directly from the corresponding deformation of the electroactive polymer.
  • Electroactive polymers deform in response to a potential that is applied to the electroactive polymer and can, for example, serve as a pump actuator as a result of this deformation, since the deformation forces a medium to be conveyed out of the pump.
  • electroactive polymers especially piezo crystals, generate an electrical potential when a mechanical force acts on them. This property is also referred to as “self-sensing” and makes it possible to use electroactive polymers as sensors in order to determine the acting forces and thus, for example, the size of the pump strokes on the basis of measured electrical potentials.
  • electroactive polymers of the dielectric type such as silicone, polyurethane or acrylic elastomer as the elastic component
  • the self-sensing of these dielectric electroactive polymers occurs in cooperation with an electrical evaluation unit, which has electrical properties (capacitance, impedance %) of the electroactive polymer or a stack of electroactive polymer determined.
  • Electroactive polymers of the dielectric type which are preferably elastic, are preferably used in the context of a pump according to the invention.
  • the at least one electroactive polymer of a pump according to the invention preferably has self-sensing properties. Using the self-sensing properties, it is thus possible to determine directly in a pump according to the invention how large each pump stroke was and whether it took place and, if applicable, how the course over time (stroke over time) was. In the event of changes, the latter can provide conclusions about aging (predictive maintenance). Particularly in the case of metering pumps which are used in the context of a blood treatment, it is essential that the volumes conveyed can be monitored precisely in this way.
  • the at least one electroactive polymer forms a pump actuator of the pump.
  • a potential or a voltage to the electroactive polymer, it can be deformed, whereby the medium to be conveyed is moved out of the pump, since the deformation / linear expansion of the electroactive polymer takes place along the direction of the pumping movement / the pump stroke of the pump.
  • the electroactive polymer can preferably drive a piston or a pump membrane or it can also be in direct contact with the medium to be conveyed.
  • a pump according to the invention several layers of electroactive polymers are preferably provided, which are preferably arranged as a “stack”. Alternatively or additionally, several such stacks of several layers of electroactive polymers can be arranged next to one another and / or one above the other.
  • a pump according to the invention preferably comprises a control unit which controls the at least one electroactive polymer to a defined deformation in order to actuate the pump. If several stacks are provided, each stack can be equipped with its own control unit, but only one common control unit can also be provided.
  • a pump according to the invention preferably comprises a measuring unit which measures the deformation of the at least one electroactive polymer and / or the distance between at least two layers of a stack of electroactive polymers in order to determine the degree of deformation or the amplitude of a pump stroke of the pump.
  • the measuring unit can be part of the control unit and / or exchange data with it.
  • the measuring device can be designed to transmit the measured data to an external receiver so that the function of the pump can be monitored and / or documented remotely.
  • the pump can be equipped with a force bundling structure which is designed to bundle the forces resulting from the deformation of the at least one electroactive polymer and to transfer them selectively to another structure, the area of the force bundling structure preferably being smaller than the area of the at least one electroactive polymer.
  • the forces / the pressure of the electroactive polymer or the stack of electroactive polymers are focused so that a higher pressure can be achieved. If the force bundling structure presses, for example, on a valve seat, a particularly reliable closing of the pump can thereby be achieved, for example.
  • two stacks of electroactive polymers arranged next to one another or one above the other can act on a common force bundling structure.
  • the at least one electroactive polymer can be connected to a pressure transducer.
  • the pressure transducer can here also be a stack of electroactive polymers, whereby the self-sensing properties are enhanced and the actuation of the pump (pump stroke, frequency, etc.) can be monitored particularly precisely.
  • the at least one electroactive polymer can be connected to the force bundling structure via the pressure transducer and / or the pressure transducer can act as a force bundling structure.
  • a dosing unit preferably a dosing unit of a blood treatment machine, with at least one pump according to the invention.
  • the dosing unit also has valves for controlling the flow of fluids such as concentrates or dialysis water.
  • the dosing unit includes a control unit by means of which the valves can be controlled.
  • Another aspect of the invention relates to a blood treatment machine, in particular a dialysis machine, with at least one pump according to the invention and / or a dosing unit according to the invention.
  • a blood treatment machine has at least two pumps according to the invention, a first pump downstream of a balancing device metering or feeding fluid, preferably concentrates, and a second pump upstream of the balancing device withdrawing fluid, preferably liquid, so that the in the balance device certain Fluidbi lance remains unchanged.
  • the two pumps according to the invention can be arranged upstream and / or downstream of a dialyzer and / or a dialysis fluid filter.
  • the first and the second pump swap their functions at predetermined times / intervals.
  • the pumps and / or control unit are thus preferably designed to swap the function of the pumps.
  • the pumps can change their function every minute, every two minutes or preferably every 10, 100 or 1000 pump strokes.
  • the frequency or the time of the swap can be determined arbitrarily.
  • the at least two pumps are designed to additionally perform an ultrafiltration. With this out Additional valves must be provided to enable the pumps to perform ultrafiltration conditions. However, an ultrafiltration pump can be omitted in this embodiment.
  • Another aspect of the invention relates to a use, for example a shoring, of a pump according to the invention in a blood treatment device, for example a dialysis machine.
  • a (single) pump according to the invention can preferably be used in the context of dosing concentrates by a blood treatment device to dose several different concentrates or solutions, such as acid concentrate and sodium bicarbonate. This is possible due to the high pumping frequency that can be achieved with a pump according to the invention.
  • a single pump according to the invention could replace two conventional diaphragm pumps.
  • the pump according to the invention is preferably two lines (first line, e.g. acid concentrate, and second line, sodium bicarbonate) or three lines (first line, e.g. acid concentrate, second line, sodium bicarbonate, third line, rinsing solution (permeate, ie pure water )) fitted.
  • first line e.g. acid concentrate
  • second line sodium bicarbonate
  • third line rinsing solution (permeate, ie pure water )
  • a blood treatment machine has a first pump according to the invention, which metered in at least two different solutions and is preferably arranged downstream of a balance device, and a first pump according to the invention, which removes liquid to the same extent and preferably upstream the image monvorraum is arranged.
  • the balancing device preferably comprises two balancing chambers, each of which has an inlet and an outlet for dialysis fluid, in particular fresh dialysis fluid on the way to the dialyzer, and an inlet and an outlet for used dialysis liquid, in particular used dialysate on the way from the dialyzer.
  • a blood treatment machine preferably has a line system for conveying fresh dialysis fluid and a line system for conveying used dialysis fluid.
  • one or more solutions are fed / metered into the line system for conveying fresh dialysis fluid at a point at which the dialysis fluid has left the balance device.
  • fresh dialysis fluid is preferably withdrawn from the line at a point at which the dialysis fluid has not yet reached the balancing device.
  • a blood treatment machine has a machine-side fluid circuit and is connected to a patient-side fluid circuit.
  • the machine-side fluid circuit is shown on the left and the patient-side fluid circuit is shown on the right.
  • the two (or also more) pumps according to the invention are arranged either in the fluid circuit on the machine side and / or in the fluid circuit on the patient side.
  • Another aspect of the invention relates to a method for measuring a printer attitude in a filter, in particular in a filter for filtering dialysing fluid or in a dialyzer, a pump according to the invention being used in the context of the method.
  • the self-sensing property of the electroactive polymer is used.
  • a defined volume of fluid is introduced into the filter to be tested.
  • the defined volume of fluid in the filter generates a certain internal pressure in the filter, which acts on the electroactive polymer in the pump.
  • the elastic polymer changes its expansion, which can be recorded by means of a measuring unit (capacitance, impedance). Any pressure loss in the filter, for example due to a leak, is thus reflected in the measured impedance profile of the electroactive polymer and can thus be recorded. If the impedance and thus the pressure in the filter remain constant, it can be concluded that the filter is intact.
  • Fig. 1 is a schematic drawing of a pump according to the invention.
  • FIG. 2 shows a flow diagram which illustrates the use of pumps according to the invention in the context of an embodiment of a blood treatment machine.
  • Fig. 3 shows the embodiment of Fig. 2 with multi-way valves instead of standard valves.
  • 3a shows an embodiment with an additional balancing chamber.
  • Fig. 4 is a flow chart which illustrates the use of pumps according to the invention in the context of another embodiment of a blood treatment machine.
  • Fig. 5 shows the embodiment from Fig. 4 with multi-way valves instead of standard valves.
  • Fig. 6 is a flow chart which ver illustrates the use of pumps according to the invention in the context of yet another embodiment of a blood treatment machine.
  • Fig. 7 shows the embodiment of Fig. 6 with multi-way valves instead of standard valves.
  • the pump 1 shown in Fig. 1 has three adjacent stacks 2 electroactive polymers.
  • the pressure generated by the stacks 2 of electroactive polymers is transmitted via a common connecting plate 3 to a force bundling structure 4, the area of which is smaller than the area of the connecting plate 3.
  • the force bundling structure 4 is connected to a pump membrane 5, which is moved up and down in accordance with the deformation of the stack 2 of electroactive polymers.
  • the longitudinal direction of the stacks 2 of electroactive polymers and the direction of the deformation of the stacks 2 are thus aligned parallel to the direction of the pump strokes of the pump 1.
  • FIG. 2 a flow diagram is reproduced which illustrates the use of pumps according to the invention in the context of a blood treatment machine.
  • Dialysis is a blood purification procedure used in patients suffering from kidney failure. Their kidneys are no longer able to filter the toxins produced by the body from the blood. Furthermore, other important processes in the regulation of the patient's water and electrolyte balance are impaired.
  • the patient's blood is brought into contact with dialysis fluid in a dialyzer through semi-permeable hollow fiber membranes.
  • This membrane allows substances, especially toxins, electrolytes and proteins, to diffuse back and forth between the liquids. Since diffusion is a process driven by concentration, the aim is to prevent foreign substances from entering the patient's blood diffuse, the dialysis fluid, the so-called dialysate, consists of ultrapure water.
  • the dialysate is additionally dosed with concentrates, e.g. electrolyte concentrates and bicarbonate.
  • concentrates e.g. electrolyte concentrates and bicarbonate.
  • the dialysis water is conveyed by a pump via a heating chamber and an air separator in the direction of the balance chamber H14.
  • the pumps P05 (concentrate pump) and P06 (bicarbonate pump) add acids (electrolytes) and bases to the water, which together result in a physiological solution.
  • An additional dialyzing fluid filter F04 with a dead volume of, for example, approx. 300 ml is arranged between the balancing chamber and the dialyzer. This dead volume is relevant for the consideration of river peaks and their smoothing, furthermore this dead volume functions like a kind of fluid reservoir.
  • the physiological solution reaches the dialyser from the dialysis fluid filter F04, where it is used to clean the blood. After the blood has been cleaned, the dialysis fluid is fed back into the balancing chamber H14 via a pump and finally ends up in the drain.
  • a P04 ultrafiltration pump (UF pump) is installed in most blood treatment machines. This is intended to withdraw additional water from the patient.
  • the ultrafiltration pump is decoupled from the balancing by means of the balancing chamber H14, since it deliberately removes water that should not be corrected.
  • the concentrate or the bicarbonate is injected or metered into the line directly in front of the balance chamber.
  • a starting point for a technical solution can therefore consist in metering the balance chamber downstream. There is significantly less pressure behind the balancing chamber.
  • FIGS 2 and 3 a flow diagram of an embodiment of the present invention is shown in which both concentrate and bicarbonate by means of pumps according to the invention (pumps with electroactive polymers, EAP pumps) behind the balance chamber H14 and directly in front of the dialysis fluid filter F04, which serves as a reservoir / mixing chamber.
  • pumps according to the invention umps with electroactive polymers, EAP pumps
  • EAP pump 7 in the stored course to / downstream of the patient “To Pat”. Since the volume metered in by means of the EAP pump 6 is known, the same volume can be removed again in a simple manner.
  • the EAP pumps mentioned here can be viewed as volumetric dosing systems. This means that dosing takes place by emptying a known pump chamber, i.e. a volume. Since the metered media are preferably liquid The amount delivered - the dose - is clearly defined with the volume or corresponds to the volume delivered by a pump stroke or a certain number of pump strokes therefore, as an intrinsic property, a higher repeatability, i.e. a higher accuracy for repeated processes.
  • a further balancing device 9 with a possibly smaller balancing chamber can be placed between the two pumps 5 and 6 and the line 8 into which the dosing is carried out 9a, as shown schematically in Fig. 3a.
  • the dialyzer is marked with D
  • the patient with P and the balancing device H 14 comprises two balancing chambers 14 a and 14 b.
  • the balancing device 9 or the balancing chamber 9a can be used to redundantly check that the dosing by the EAP pumps was exact and that increased safety is achieved as a result: This also ensures that the dosing volume is withdrawn again exactly which was previously added to the dialysate circuit during dosing.
  • any other pumps can be used for dosing instead of EAP pumps, such as peristaltic pumps, Diaphragm pumps, gear pumps, centrifugal pumps - for example impeller pumps.
  • the properties (small strokes, high frequencies) of the pumps according to the invention make it possible to combine different pump functions (e.g. pumping different solutions).
  • a blood treatment machine in which a bi-carbonate, a concentrate and an ultrafiltration pump (UF pump) are designed as pumps according to the invention.
  • the UF pump must be able to do this be able to withdraw both the usual volume to be withdrawn per treatment and the electrolyte and bicarbonate volume to be dosed.
  • a single pump according to the invention can also pump bicarbonate and concentrate and a UF pump can also be provided, which is either a pump according to the invention with electroactive polymers or a conventional series pump.
  • a pump according to the invention in addition a UF pump and a balance pump can be provided, each of which is either a pump according to the invention with electroactive polymers or a conventional series pump.
  • the task of the balance pump is to remove the volume supplied via the bicarbonate / concentrate pump.
  • the UF pump therefore only has to deliver the usual UF volume.
  • the functions of the bicarbonate, concentrate and UF pumps could also be combined in a single pump according to the invention, which is preferably present at least twice in the blood treatment device.
  • the first EAP pump 6 takes over the dosing / feeding of bicarbonate and concentrate; whereby, as shown in FIG. 5, a multi-way valve can be used to switch between the two fluids.
  • the fluids can also be switched using regular valves (see FIG. 4). Since the dosing / feeding takes place downstream of the balancing chamber but upstream of the patient (see flow path “Before Pat”), the amount of fluid fed in must be removed again in order to prevent overhydration of the patient. Therefore, after the patient (see flow path “After Pat”), fluid is withdrawn from the system, which is taken over by the second EAP pump 7. The original UF pump P04 remains in the system.
  • both pumps 6 and 7 can take over both the feeding and the removal of liquid.
  • a pump always has certain tolerances and thus a certain inaccuracy when pumping a defined volume. This leads to errors occurring both when adding (dosing errors) and when removing liquid. Viewed as a whole, this leads to accounting errors.
  • the EAP pump used or several EAP pumps used with the associated valves can be installed in a pump unit.
  • the metering pump (s) and the valves are preferably installed on one unit and can be operated by a central control. This can also include valves, which are required to feed fluids downstream of the balancing chamber.
  • This own control unit has its own CPU, for example, which enables significantly shorter processing times compared to using the machine software. This reduced processing time makes it possible to achieve higher pump frequencies.
  • the only input parameter required is the desired delivery rate; the required frequency and the required pump volume are then preferably calculated by the separate control unit.
  • FIG. 6 shows a further embodiment of a blood treatment machine which has a pump 6 according to the invention and an ultrafiltration pump P04.
  • the pump 6 according to the invention pumps both concentrate and bicarbonate and the ultrafiltration pump P04 is preferably also designed as an EAP pump according to the invention, but can also be a different type of pump.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • External Artificial Organs (AREA)

Abstract

La présente invention concerne une pompe (1) comprenant un actionneur de pompe (2) qui comprend au moins un polymère électroactif, l'au moins un polymère électroactif étant disposé de telle sorte qu'une déformation de l'au moins un polymère électroactif se produit le long de la direction de la course de pompage de la pompe. L'invention concerne également une machine de traitement de sang comprenant une telle pompe. Un autre aspect de l'invention concerne un procédé de mesure de maintenance de pression utilisant une telle pompe.
EP21716971.3A 2020-03-30 2021-03-25 Pompe comportant des polymères électroactifs Pending EP4128376A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102020108755.1A DE102020108755A1 (de) 2020-03-30 2020-03-30 Pumpe mit elektroaktiven Polymeren
PCT/EP2021/057684 WO2021197994A1 (fr) 2020-03-30 2021-03-25 Pompe comportant des polymères électroactifs

Publications (1)

Publication Number Publication Date
EP4128376A1 true EP4128376A1 (fr) 2023-02-08

Family

ID=75426560

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21716971.3A Pending EP4128376A1 (fr) 2020-03-30 2021-03-25 Pompe comportant des polymères électroactifs

Country Status (3)

Country Link
EP (1) EP4128376A1 (fr)
DE (1) DE102020108755A1 (fr)
WO (1) WO2021197994A1 (fr)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005522162A (ja) 2002-03-18 2005-07-21 エスアールアイ インターナショナル 流体を移動させる電気活性ポリマーデバイス
DE102014218981A1 (de) * 2013-11-20 2015-05-21 Robert Bosch Gmbh Druckerzeugungsvorrichtung mit EAP Aktor
DE102016010222A1 (de) * 2016-08-20 2018-02-22 Fresenius Medical Care Deutschland Gmbh Vorrichtung und Verfahren zur Bereitstellung von Dialysierflüssigkeit und Dialysevorrichtung
EP3490017A1 (fr) * 2017-11-27 2019-05-29 Siemens Aktiengesellschaft Dispositif d'actionnement pourvu d'actionneur de corps fixe et d'unité hydraulique

Also Published As

Publication number Publication date
WO2021197994A1 (fr) 2021-10-07
DE102020108755A1 (de) 2021-09-30

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