EP4058770B1 - Method of integrity testing of a single-use system - Google Patents

Method of integrity testing of a single-use system

Info

Publication number
EP4058770B1
EP4058770B1 EP20803613.7A EP20803613A EP4058770B1 EP 4058770 B1 EP4058770 B1 EP 4058770B1 EP 20803613 A EP20803613 A EP 20803613A EP 4058770 B1 EP4058770 B1 EP 4058770B1
Authority
EP
European Patent Office
Prior art keywords
use system
integrity
test gas
specifically
test
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP20803613.7A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP4058770A2 (en
EP4058770C0 (en
Inventor
Karen AECHTLER
Thomas RAETZ
Gerald Zieres
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of EP4058770A2 publication Critical patent/EP4058770A2/en
Application granted granted Critical
Publication of EP4058770B1 publication Critical patent/EP4058770B1/en
Publication of EP4058770C0 publication Critical patent/EP4058770C0/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01M—TESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
    • G01M3/00—Investigating fluid-tightness of structures
    • G01M3/02—Investigating fluid-tightness of structures by using fluid or vacuum
    • G01M3/04—Investigating fluid-tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point
    • G01M3/20—Investigating fluid-tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using special tracer materials, e.g. dye, fluorescent material, radioactive material
    • G01M3/22—Investigating fluid-tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using special tracer materials, e.g. dye, fluorescent material, radioactive material for pipes, cables or tubes; for pipe joints or seals; for valves; for welds; for containers, e.g. radiators
    • G01M3/226—Investigating fluid-tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using special tracer materials, e.g. dye, fluorescent material, radioactive material for pipes, cables or tubes; for pipe joints or seals; for valves; for welds; for containers, e.g. radiators for containers, e.g. radiators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01M—TESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
    • G01M3/00—Investigating fluid-tightness of structures
    • G01M3/002—Investigating fluid-tightness of structures by using thermal means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J5/00—Radiation pyrometry, e.g. infrared or optical thermometry
    • G01J5/0014—Radiation pyrometry, e.g. infrared or optical thermometry for sensing the radiation from gases, flames
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01M—TESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
    • G01M3/00—Investigating fluid-tightness of structures
    • G01M3/02—Investigating fluid-tightness of structures by using fluid or vacuum
    • G01M3/04—Investigating fluid-tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point
    • G01M3/20—Investigating fluid-tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using special tracer materials, e.g. dye, fluorescent material, radioactive material
    • G01M3/22—Investigating fluid-tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using special tracer materials, e.g. dye, fluorescent material, radioactive material for pipes, cables or tubes; for pipe joints or seals; for valves; for welds; for containers, e.g. radiators
    • G01M3/226—Investigating fluid-tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using special tracer materials, e.g. dye, fluorescent material, radioactive material for pipes, cables or tubes; for pipe joints or seals; for valves; for welds; for containers, e.g. radiators for containers, e.g. radiators
    • G01M3/227—Investigating fluid-tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using special tracer materials, e.g. dye, fluorescent material, radioactive material for pipes, cables or tubes; for pipe joints or seals; for valves; for welds; for containers, e.g. radiators for containers, e.g. radiators for flexible or elastic containers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01M—TESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
    • G01M3/00—Investigating fluid-tightness of structures
    • G01M3/38—Investigating fluid-tightness of structures by using light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J5/00—Radiation pyrometry, e.g. infrared or optical thermometry
    • G01J2005/0077—Imaging

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Examining Or Testing Airtightness (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
EP20803613.7A 2019-11-14 2020-11-13 Method of integrity testing of a single-use system Active EP4058770B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19209197 2019-11-14
PCT/EP2020/082085 WO2021094554A2 (en) 2019-11-14 2020-11-13 Method of integrity testing of a single-use system

Publications (3)

Publication Number Publication Date
EP4058770A2 EP4058770A2 (en) 2022-09-21
EP4058770B1 true EP4058770B1 (en) 2026-03-18
EP4058770C0 EP4058770C0 (en) 2026-03-18

Family

ID=68581620

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20803613.7A Active EP4058770B1 (en) 2019-11-14 2020-11-13 Method of integrity testing of a single-use system

Country Status (5)

Country Link
US (1) US12560503B2 (cg-RX-API-DMAC10.html)
EP (1) EP4058770B1 (cg-RX-API-DMAC10.html)
JP (1) JP7668796B2 (cg-RX-API-DMAC10.html)
CN (1) CN114729846A (cg-RX-API-DMAC10.html)
WO (1) WO2021094554A2 (cg-RX-API-DMAC10.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12182226B2 (en) * 2021-09-10 2024-12-31 Microsoft Technology Licensing, Llc Neural-network-based mapping of potential leakage pathways of subsurface carbon dioxide storage
US12517001B2 (en) * 2023-08-03 2026-01-06 GM Global Technology Operations LLC Optical gas imaging system for leak detection during battery manufacturing
US20250389608A1 (en) * 2024-06-24 2025-12-25 GM Global Technology Operations LLC Cell testing systems and control logic for automated in-line leak detection in prismatic battery cells
CN120385468B (zh) * 2025-06-27 2025-08-26 太原科技大学 一种六面顶压机用密封检测方法及系统

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190137386A1 (en) * 2016-04-20 2019-05-09 Konica Minolta, Inc. Gas observation method

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DE4111686A1 (de) * 1991-04-10 1992-10-22 Egm Entwicklung Montage Verfahren und vorrichtung zur beruehrungslosen dichtigkeitspruefung
DE4321644A1 (de) 1993-06-30 1995-01-12 Nord Systemtechnik Vorrichtung zur Feststellung von Undichtigkeiten an Bauteilen
JP3779790B2 (ja) * 1997-03-05 2006-05-31 株式会社常盤産業 シール包装された包装体の検査方法
JP2000088781A (ja) * 1998-09-10 2000-03-31 Nikkiso Co Ltd 熱シール包装検査装置
JP2000227407A (ja) 1998-11-30 2000-08-15 Nikkiso Co Ltd 熱シール部検査装置
US7939804B2 (en) * 2008-11-26 2011-05-10 Fluke Corporation System and method for detecting gas leaks
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US9225915B2 (en) * 2012-07-06 2015-12-29 Providence Photonics, Llc Calibration and quantification method for gas imaging camera
US9170193B2 (en) * 2013-06-06 2015-10-27 General Electric Company Detecting coolant leaks in turbine generators
KR20160067092A (ko) 2013-10-02 2016-06-13 에프. 호프만-라 로슈 아게 누출 검출을 위한 장치
WO2015140797A2 (en) 2014-03-20 2015-09-24 D.I.R. Technologies (Detection Ir) Ltd. Method and system for determining package integrity
US9671331B2 (en) * 2014-10-07 2017-06-06 Providence Photonics, Llc Apparatus for imaging hydrogen sulfide plume and method of the same
US10408763B2 (en) 2015-01-30 2019-09-10 Mécanique Analytique Inc. Systems and methods for testing for a gas leak through a gas flow component
US20170138813A1 (en) * 2015-11-13 2017-05-18 General Electric Company System and method for detecting leaks in generators
WO2017197521A1 (en) * 2016-05-18 2017-11-23 Lineriders Inc. Apparatus and methodologies for leak detection using gas and infrared thermography
CN109154538B (zh) * 2016-05-18 2021-02-02 多传感器科学公司 烃泄漏成像和定量传感器
JP2020509364A (ja) 2017-02-20 2020-03-26 ヨラン イメージング リミテッドＹｏｒａｎ Ｉｍａｇｉｎｇ Ｌｔｄ． パッケージ完全性を決定するための方法およびシステム
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Publication number Priority date Publication date Assignee Title
US20190137386A1 (en) * 2016-04-20 2019-05-09 Konica Minolta, Inc. Gas observation method

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NATHAN HAGEN ET AL: "Video-rate spectral imaging of gas leaks in the longwave infrared", SPIE PROCEEDINGS, vol. 8710, 29 May 2013 (2013-05-29), US, pages 871005, XP055690622, ISBN: 978-1-5106-3673-6, DOI: 10.1117/12.2015520 *

Also Published As

Publication number Publication date
US20220268658A1 (en) 2022-08-25
EP4058770A2 (en) 2022-09-21
JP7668796B2 (ja) 2025-04-25
WO2021094554A3 (en) 2021-06-24
JP2023501660A (ja) 2023-01-18
US12560503B2 (en) 2026-02-24
EP4058770C0 (en) 2026-03-18
CN114729846A (zh) 2022-07-08
WO2021094554A2 (en) 2021-05-20

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