EP4044900A1 - Procédé de fabrication d'un capteur épidermique ultra-mince et capteur obtenu - Google Patents
Procédé de fabrication d'un capteur épidermique ultra-mince et capteur obtenuInfo
- Publication number
- EP4044900A1 EP4044900A1 EP19813642.6A EP19813642A EP4044900A1 EP 4044900 A1 EP4044900 A1 EP 4044900A1 EP 19813642 A EP19813642 A EP 19813642A EP 4044900 A1 EP4044900 A1 EP 4044900A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- sensor
- electrode
- thickness
- acquisition portion
- holes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract description 30
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 12
- 239000000463 material Substances 0.000 claims abstract description 27
- 230000008021 deposition Effects 0.000 claims abstract description 8
- 239000012808 vapor phase Substances 0.000 claims abstract description 6
- 239000007791 liquid phase Substances 0.000 claims abstract 5
- VRBFTYUMFJWSJY-UHFFFAOYSA-N 28804-46-8 Chemical compound ClC1CC(C=C2)=CC=C2C(Cl)CC2=CC=C1C=C2 VRBFTYUMFJWSJY-UHFFFAOYSA-N 0.000 claims description 14
- 238000000151 deposition Methods 0.000 claims description 9
- 238000000206 photolithography Methods 0.000 claims description 3
- 238000001020 plasma etching Methods 0.000 claims description 3
- 238000004080 punching Methods 0.000 claims description 2
- 239000010410 layer Substances 0.000 description 25
- 210000002615 epidermis Anatomy 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 238000012545 processing Methods 0.000 description 5
- 239000000758 substrate Substances 0.000 description 5
- 230000005068 transpiration Effects 0.000 description 4
- 210000004207 dermis Anatomy 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 210000004877 mucosa Anatomy 0.000 description 3
- 210000004243 sweat Anatomy 0.000 description 3
- 230000008719 thickening Effects 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 238000005553 drilling Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 229920002120 photoresistant polymer Polymers 0.000 description 2
- 229920003207 poly(ethylene-2,6-naphthalate) Polymers 0.000 description 2
- 239000011112 polyethylene naphthalate Substances 0.000 description 2
- -1 polyethylene terephthalate Polymers 0.000 description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 description 2
- 239000005020 polyethylene terephthalate Substances 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 210000003491 skin Anatomy 0.000 description 2
- 230000035900 sweating Effects 0.000 description 2
- 101100136092 Drosophila melanogaster peng gene Proteins 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000004962 Polyamide-imide Substances 0.000 description 1
- 229910021607 Silver chloride Inorganic materials 0.000 description 1
- 239000004963 Torlon Substances 0.000 description 1
- 229920003997 Torlon® Polymers 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000005234 chemical deposition Methods 0.000 description 1
- 238000005229 chemical vapour deposition Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000005669 field effect Effects 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 229910021389 graphene Inorganic materials 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 238000007641 inkjet printing Methods 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000000813 microcontact printing Methods 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920000052 poly(p-xylylene) Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920002312 polyamide-imide Polymers 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000007650 screen-printing Methods 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
- A61B5/1477—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means non-invasive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/296—Bioelectric electrodes therefor specially adapted for particular uses for electromyography [EMG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0209—Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/028—Microscale sensors, e.g. electromechanical sensors [MEMS]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
- A61B2562/125—Manufacturing methods specially adapted for producing sensors for in-vivo measurements characterised by the manufacture of electrodes
Definitions
- the invention is part of the so-called “epidermal electronics” or “tattoo electronics”. These are ultra-thin epidermal sensors connected to an acquisition electronics for the measurement of physiological electrical signals, in particular for the detection of EMG, ECG, EEG, EOG bio-potentials and other physical and chemical parameters such as for example pH and temperature.
- These sensors are made in a sandwich configuration using a deposition techniques, in which an electrode is packed.
- the sensor identifies an acquisition portion in which the acquisition portions of one or more electrodes and a connection portion are present, in which the buses of each isolated electrode, i.e. passivated with respect to the external environment, run up to define a sort of flat cable band suitable to be inserted in a ZIF connector or similar, associated with an electronic signal acquisition and processing card.
- the senor is broken in the connection portion that allows the interconnection with the aforementioned ZIF connector or similar.
- a further object of the present invention is to present a sensor that is more robust than known ones.
- Another object of the present invention is to present a sensor which is simultaneously more robust than those known and less sensitive to sweating.
- the basic idea of the present invention is to manufacture an ultra- thin epidermal sensor and to carry out a procedure of further selective removal of material after its manufacture. More precisely, through openings are made in the thickness of the sensor in order to promote sweat transpiration generated by the epidermis and/or a surface layer of material is removed from the acquisition portion of the sensor, by defining a thickening of the connecting portion of the sensor so as to make the sensor more resistant at the interface with the electronic card for acquisition and/or processing of physiological signals. More preferably, the removal of excess material is achieved by obtaining a moderate gradient between the two zones: acquisition portion and interconnection portion.
- this allows to avoid the breakage of the interface portion between the sensor, intended to be attached to the epidermis, and the device for acquisition and/or processing of physiological signals.
- Physiological signals are acquired in the form of electrical signals.
- the sensor is of the passive type it is intended to directly acquire typical electrical signals for example of EMG, ECG, etc.
- the electrical signals can be either both EMG, ECG signals, etc., and signals of chemical nature (for example the chemical composition of sweat, pH skin, etc.).
- the material deposited in the deposition procedures is in excess of that is strictly necessary and is followed by a further selective removal procedure, aimed at making openings passing through the thickness of the sensor and/or aimed at determining a thinning of the acquisition portion with a corresponding thickening of the connecting portion of the sensor.
- the sensor obtained by the present method can advantageously be used for the detection of EMG, ECG, EEG, EOG bio-potentials and other physical and chemical parameters such as for example pH and temperature, by solving the problem of dermis transpiration. It also allows the simultaneous dosing of a fluid substance through the same sensor, in order to stimulate a bioelectric response or to restore the hydration of the dermis.
- the present invention also finds application in the field of robotics and in particular in the field of tactile sensors.
- the claims describe preferred embodiments of the invention, forming an integral part of the present description.
- Figure 1 shows a part of a method of manufacturing an epidermal sensor according to the present invention
- Figure 2 shows a portion of the method which replaces or integrates the last step of the method of Figure 1 ;
- Figure 3 shows an assembly and a relative exploded view of an example of a sensor obtained according to a variant of the method of the present invention
- Figure 4 shows an assembly and a relative exploded view of another example of a sensor obtained according to another variant of the method of the present invention.
- the proposed technique is compatible with known manufacturing processes per se, such as standard photolithography, ink-jet printing, silk- screen printing, micro-contact printing, roll-to-roll and allows to obtain ultra-thin sensors with high transpiration properties as well as of biocompatibility and conformability, i.e. an optimal adherence to any substrate, skin, mucosa, etc..
- the sensor Sens according to the present invention includes a flat and ultra-thin casing of Parylene C in which a flat electrode L3 is embedded, of which only one acquisition portion is uncovered on one of the two opposite faces of the sensor. Therefore, the sensor defines an acquisition portion SA in which the acquisition portion of the electrode is present and reachable from the outside and a connecting portion PB which incorporates and isolates the buses of at least one electrode from the outside.
- the connection portion on one side prevents the buses from contacting the epidermis or mucosa by collecting unwanted signals. On the other hand it allows the sensor to be connected to a socket of the signal acquisition and/or processing device.
- the senor defines an ultra-thin and flexible flat plate.
- the manufacturing method object of the present invention comprises the following steps in succession.
- Step 1 Deposition of a water-soluble polymeric sacrificial first LI layer, such as preferably PVA (polyvinyl alcohol) on a support plastic substrate L0, called carrier, such as PET (polyethylene terephthalate), PEN (polyethylene naphthalate), KaptonTM (polyamide film developed from DuPont®), etc.
- Step 2. Vapor phase chemical deposition, known with Anglo-
- a second ultra- thin L2 layer preferably of Parylene C or Torlon ® (polyamide-imide) on said first layer, preferably with a thickness of between 300 and 500 nm.
- Step 3 Arrangement of at least one measuring electrode L3, preferably in silver or silver-chloride, preferably by photolithographic technique, known per se, on said second layer.
- the measuring electrode that defines a third layer of the sensor has a predetermined shape. It may include matrices of electrodes, microelectrodes, both passive and active, as they can include organic transistors for the detection of chemical and physical parameters etc.
- the electrode can be either metallic or carbon-based, and it is important that it is conductive.
- Step 4 Deposition of a fourth layer L4 of Parylene C with a thickness between 500 nm and 4,5 pm, in the same manner as in step 2, so that the electrode is packed between the second and fourth layers, both made of Parylene C.
- Parylene C is mentioned as being considered to be particularly suitable, but it is not the only material that can be used for these purposes.
- the upper limit of 4,5 pm is chosen as a function of the flexibility and adhesion capacity conferred by Parylene C on the dermis. Therefore, if materials are identified that offer better adhesion, this limit may be exceeded.
- step SP4 it is clearly seen in step SP4 that the thickness of the fourth layer L4 of Parylene C is greater than the thickness of the second layer L2 of Parylene C.
- the second and fourth layers of Parylene C are in direct contact with each other in the perimeter areas with respect to the electrode L3.
- the electrode covers only a portion of the surface of the second layer allowing a subsequent mutual adhesion between the second and the fourth layer to be determined.
- the deposition technique allows that in direct contact portions between the second and fourth layer, a single and isotropic layer is defined, in which it is not possible to recognize an interface between the second and fourth layer.
- the fourth layer of Parylene C is intended to come into contact with the epidermis and must therefore expose the electrode towards the outside, so that the latter can carry out the aforementioned physiological acquisitions.
- Step 5 Removal of the portion of the fourth layer covering the acquisition portion of the electrode, for example by means of the photolithography technique based on plasma etching.
- the ultra-thin sensor obtained is similar to that of the known art.
- further removal of material is performed, - in order to obtain a diversification between the thickness of the acquisition portion and the connecting portion, and/or - in order to drill through holes at least in the thickness of the acquisition portion of the sensor.
- Step 5bis Removal of material to obtain a greater thickness in the connection portion of the sensor with respect to the active portion of the same sensor and to uncover the acquisition portion of the electrode, and/or
- the removal of material to diversify the thicknesses can be carried out before or after the removal of material for uncovering the acquisition portion of the electrode.
- the through holes are made as the last procedure.
- the holes are preferably distributed evenly over the surface of the sensor so as to optimize the transpiration of the epidermis or in an appropriate way in cases where the openings are made to allow the administration of a fluid stimulation substance.
- the holes are distributed not only peripherally with respect to the electrode, but also through the electrode, therefore the following step is performed.
- Step 7 Making of holes in the electrode by means of a photolithographic technique and subsequent continuation of the holes with the same masking made for removing the electrode portions, in the second layer L2 of Parylene C, thus creating openings passing through the second and third layer.
- step 6 the typical secondary steps of the photolithographic technique are shown in which a layer of photoresist is deposited, which is selectively removed in order to define the uncovered portions of the underlying material subject to subsequent removal, the removal of the underlying material and finally of the photoresist being made by means of a suitable diluent.
- the through holes can also be made by mechanically drilling the sensor.
- a roller with sharp bumps can be pressed and slid on the sensor so as to perforate the sensor itself. In other words, it is a punching procedure.
- a laser emitter can be used to pierce the sensor.
- the through openings described above may have a more or less regular geometry depending on the drilling technique used. It is believed that the geometry of the through openings is not essential, although it is preferable to make holes, i.e. approximately circular- shaped openings.
- the first sacrificial layer can be removed after the aforementioned steps, for example by immersion in a diluent, for example water, capable of dissolving the material of which the sacrificial layer is made or by mechanical removal, peeling (peel-off).
- a diluent for example water
- the thinning of the fourth layer for obtaining a more or less gradual thickening of the portion of the sensor which contains the buses intended to be connected to the socket of the signal acquisition and/or processing device, it is envisaged to carry it out using the technique of plasma etching by performing a step 5 c after step 5 a or 5b or it can be performed simultaneously.
- the sensor Sens of the present invention has been tested in electromyographic applications by making matrices of passive and tactile electrodes and to realize temperature and pressure sensors based on organic field effect devices.
- Figure 3 shows a variant in which they are present simultaneously: - Thinning of the acquisition portion SA of the sensor with respect to a connection portion SB in which the electrode connection buses are collected.
- Figure 4 shows a variant in which they are present simultaneously:
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Pathology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Optics & Photonics (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
L'invention concerne un procédé de fabrication d'un capteur épidermique ultra-mince du type dans lequel une électrode (L3) est intégrée dans un boîtier plat (L2, L4) en matériau polymère qui peut être déposé par dépôt en phase vapeur ou en phase liquide, présentant une épaisseur micrométrique ou sub-micrométrique, et le capteur comprenant une partie d'acquisition (SA) dans laquelle l'électrode est accessible depuis l'extérieur par une face du boîtier, et une partie de raccordement (SB) qui incorpore et isole au moins un bus électrique (PE) de connexion de l'électrode (L3), le procédé comprenant une étape d'élimination de matière sur l'une des faces du capteur, pour obtenir une diversification (étape 5 bis) entre l'épaisseur de la partie d'acquisition et l'épaisseur de la partie de raccordement, et/ou pour percer des trous traversants (étape 6) au moins avec l'épaisseur de la partie d'acquisition du capteur.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB2019/058726 WO2021074664A1 (fr) | 2019-10-14 | 2019-10-14 | Procédé de fabrication d'un capteur épidermique ultra-mince et capteur obtenu |
Publications (1)
Publication Number | Publication Date |
---|---|
EP4044900A1 true EP4044900A1 (fr) | 2022-08-24 |
Family
ID=68766797
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19813642.6A Pending EP4044900A1 (fr) | 2019-10-14 | 2019-10-14 | Procédé de fabrication d'un capteur épidermique ultra-mince et capteur obtenu |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP4044900A1 (fr) |
WO (1) | WO2021074664A1 (fr) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20170215800A1 (en) * | 2016-01-29 | 2017-08-03 | Zentan Technology Co., Ltd. | Wearable device |
US20180165566A1 (en) * | 2015-06-01 | 2018-06-14 | The Board Of Trustees Of The University Of Illinois | Miniaturized electronic systems with wireless power and near-field communication capabilities |
EP3463054A1 (fr) * | 2016-06-06 | 2019-04-10 | Università Degli Studi di Cagliari | Dispositif, système et procédé associé d'évaluation quantitative de la sensibilité gustative |
-
2019
- 2019-10-14 WO PCT/IB2019/058726 patent/WO2021074664A1/fr unknown
- 2019-10-14 EP EP19813642.6A patent/EP4044900A1/fr active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20180165566A1 (en) * | 2015-06-01 | 2018-06-14 | The Board Of Trustees Of The University Of Illinois | Miniaturized electronic systems with wireless power and near-field communication capabilities |
US20170215800A1 (en) * | 2016-01-29 | 2017-08-03 | Zentan Technology Co., Ltd. | Wearable device |
EP3463054A1 (fr) * | 2016-06-06 | 2019-04-10 | Università Degli Studi di Cagliari | Dispositif, système et procédé associé d'évaluation quantitative de la sensibilité gustative |
Non-Patent Citations (3)
Title |
---|
JAE-WOONG JEONG ET AL: "Materials and Optimized Designs for Human-Machine Interfaces Via Epidermal Electronics", ADVANCED MATERIALS, vol. 25, no. 47, 25 September 2013 (2013-09-25), pages 6839 - 6846, XP055650413, ISSN: 0935-9648, DOI: 10.1002/adma.201301921 * |
PENG HUI-LING ET AL: "Parylene-based flexible dry electrode for bioptential recording", SENSORS AND ACTUATORS B: CHEMICAL, vol. 231, August 2016 (2016-08-01), pages 1 - 11, XP029520850, ISSN: 0925-4005, DOI: 10.1016/J.SNB.2016.02.061 * |
See also references of WO2021074664A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO2021074664A1 (fr) | 2021-04-22 |
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