EP3931182A4 - Procédé de préparation de 6-(1-acryloylpipéridin-4-yl)-2-(4-phénoxyphényl) nicotinamide - Google Patents
Procédé de préparation de 6-(1-acryloylpipéridin-4-yl)-2-(4-phénoxyphényl) nicotinamide Download PDFInfo
- Publication number
- EP3931182A4 EP3931182A4 EP20762224.2A EP20762224A EP3931182A4 EP 3931182 A4 EP3931182 A4 EP 3931182A4 EP 20762224 A EP20762224 A EP 20762224A EP 3931182 A4 EP3931182 A4 EP 3931182A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- acryloylpiperidin
- phenoxyphenyl
- nicotinamide
- preparing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Health & Medical Sciences (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962810305P | 2019-02-25 | 2019-02-25 | |
| PCT/CN2020/076387 WO2020173407A1 (fr) | 2019-02-25 | 2020-02-24 | Procédé de préparation de 6-(1-acryloylpipéridin-4-yl)-2-(4-phénoxyphényl) nicotinamide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP3931182A1 EP3931182A1 (fr) | 2022-01-05 |
| EP3931182A4 true EP3931182A4 (fr) | 2023-01-25 |
Family
ID=72238782
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP20762224.2A Pending EP3931182A4 (fr) | 2019-02-25 | 2020-02-24 | Procédé de préparation de 6-(1-acryloylpipéridin-4-yl)-2-(4-phénoxyphényl) nicotinamide |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20210380555A1 (fr) |
| EP (1) | EP3931182A4 (fr) |
| JP (1) | JP2022521763A (fr) |
| KR (1) | KR20210131374A (fr) |
| CN (1) | CN113454066B (fr) |
| AU (1) | AU2020229919A1 (fr) |
| BR (1) | BR112021016787A2 (fr) |
| CA (1) | CA3131302A1 (fr) |
| MX (1) | MX2021010199A (fr) |
| SG (1) | SG11202109213RA (fr) |
| TW (1) | TWI830876B (fr) |
| WO (1) | WO2020173407A1 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115894440A (zh) * | 2022-10-27 | 2023-04-04 | 都创(重庆)医药科技有限公司 | 奥布替尼化合物的晶型及其制备方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015048662A2 (fr) * | 2013-09-30 | 2015-04-02 | X-Rx Discovery, Inc. | Inhibiteurs de nicotinimide substitués de btk et leur préparation et utilisation dans le traitement du cancer, d'inflammations et des maladies auto-immunes |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2648923A1 (fr) * | 2006-04-11 | 2007-10-18 | Vertex Pharmaceuticals Incorporated | Thiazoles, imidazoles, et pyrazoles utiles en tant qu'inhibiteurs de proteines kinases |
| CN107226805A (zh) * | 2016-03-24 | 2017-10-03 | 北京天诚医药科技有限公司 | 芳香族酰胺类衍生物、其制备方法及其在医药上的应用 |
| EP3876911A4 (fr) * | 2018-11-06 | 2022-06-22 | Beijing InnoCare Pharma Tech Co., Ltd. | Dispersion solide amorphe de 6-(1-acryloylpipéridine-4-yl)-2-(4-phénoxyphényl) nicotinamide |
-
2020
- 2020-02-24 CA CA3131302A patent/CA3131302A1/fr active Pending
- 2020-02-24 EP EP20762224.2A patent/EP3931182A4/fr active Pending
- 2020-02-24 JP JP2021549695A patent/JP2022521763A/ja active Pending
- 2020-02-24 SG SG11202109213RA patent/SG11202109213RA/en unknown
- 2020-02-24 MX MX2021010199A patent/MX2021010199A/es unknown
- 2020-02-24 CN CN202080015876.7A patent/CN113454066B/zh active Active
- 2020-02-24 AU AU2020229919A patent/AU2020229919A1/en active Pending
- 2020-02-24 BR BR112021016787A patent/BR112021016787A2/pt unknown
- 2020-02-24 WO PCT/CN2020/076387 patent/WO2020173407A1/fr unknown
- 2020-02-24 KR KR1020217029894A patent/KR20210131374A/ko active Search and Examination
- 2020-02-25 TW TW109106065A patent/TWI830876B/zh active
-
2021
- 2021-08-20 US US17/407,340 patent/US20210380555A1/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015048662A2 (fr) * | 2013-09-30 | 2015-04-02 | X-Rx Discovery, Inc. | Inhibiteurs de nicotinimide substitués de btk et leur préparation et utilisation dans le traitement du cancer, d'inflammations et des maladies auto-immunes |
Also Published As
| Publication number | Publication date |
|---|---|
| TW202031642A (zh) | 2020-09-01 |
| AU2020229919A1 (en) | 2021-10-14 |
| BR112021016787A2 (pt) | 2021-11-16 |
| CN113454066A (zh) | 2021-09-28 |
| KR20210131374A (ko) | 2021-11-02 |
| JP2022521763A (ja) | 2022-04-12 |
| CN113454066B (zh) | 2024-02-09 |
| CA3131302A1 (fr) | 2020-09-03 |
| WO2020173407A1 (fr) | 2020-09-03 |
| EP3931182A1 (fr) | 2022-01-05 |
| MX2021010199A (es) | 2021-09-21 |
| SG11202109213RA (en) | 2021-09-29 |
| US20210380555A1 (en) | 2021-12-09 |
| TWI830876B (zh) | 2024-02-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP4029849A4 (fr) | Procédé de préparation de m-trifluorométhylphénol | |
| EP3770711A4 (fr) | Procédé de repositionnement de robot | |
| EP3505264A4 (fr) | Procédé permettant à un robot de trouver automatiquement une position de flexion | |
| EP3706725A4 (fr) | Processus pour la préparation de tapinarof | |
| EP3556522A4 (fr) | Procédé de commande de robot | |
| EP3751001A4 (fr) | Procédé de fabrication d'ergothionéine | |
| EP3658552A4 (fr) | Procédé amélioré pour la préparation de dérivés d'aminopyrimidine | |
| EP3804853A4 (fr) | Procédé de préparation d'indoxacarb s | |
| EP3611253A4 (fr) | Procédé de production de théanine | |
| EP3980013A4 (fr) | Procédés de préparation de composés aminopyrimidine | |
| EP3606380A4 (fr) | Procédé pour la fabrication d'étagères | |
| EP3733648A4 (fr) | Procédé de préparation d'acide 5r-benzyloxyaminopipéridin-2s-carboxylique ou d'un dérivé de celui-ci | |
| EP3870184A4 (fr) | Compositions de nicotinamide riboside pour prolonger la durée de vie en bonne santé | |
| EP3756133A4 (fr) | Procédé d'authentification d'articles | |
| EP3597674A4 (fr) | Procédé de préparation de copolymère | |
| EP4011868A4 (fr) | Procédé de préparation d'un composé de pyrazine-2 (1h)-cétone | |
| EP3950181A4 (fr) | Appareil de fabrication tridimensionnelle | |
| EP3696168A4 (fr) | Procédé de préparation de 2-chloro-5-trifluorométhylpyridine | |
| EP3647304A4 (fr) | Procédé de préparation de 2-fluoroacrylate | |
| EP3931182A4 (fr) | Procédé de préparation de 6-(1-acryloylpipéridin-4-yl)-2-(4-phénoxyphényl) nicotinamide | |
| EP3876911A4 (fr) | Dispersion solide amorphe de 6-(1-acryloylpipéridine-4-yl)-2-(4-phénoxyphényl) nicotinamide | |
| EP3652158A4 (fr) | Procédé de préparation d'un composé de pyrimidone | |
| EP3732007A4 (fr) | Bois densifié faisant appel à un procédé de préparation | |
| EP3604283A4 (fr) | Procédé de production d'acide pyrazolecarboxylique halogéné | |
| EP3768487A4 (fr) | Procédé de micromoulages d'articles |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
| 17P | Request for examination filed |
Effective date: 20210921 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
| DAV | Request for validation of the european patent (deleted) | ||
| DAX | Request for extension of the european patent (deleted) | ||
| RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07D 401/04 20060101AFI20220909BHEP |
|
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20221223 |
|
| RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07D 401/04 20060101AFI20221219BHEP |