EP3861974B1 - Kapselverschliesseinrichtung zum verschliessen zweiteiliger kapseln - Google Patents

Kapselverschliesseinrichtung zum verschliessen zweiteiliger kapseln Download PDF

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Publication number
EP3861974B1
EP3861974B1 EP20156171.9A EP20156171A EP3861974B1 EP 3861974 B1 EP3861974 B1 EP 3861974B1 EP 20156171 A EP20156171 A EP 20156171A EP 3861974 B1 EP3861974 B1 EP 3861974B1
Authority
EP
European Patent Office
Prior art keywords
capsule
receptacle
bore
closing device
diameter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP20156171.9A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP3861974A1 (de
Inventor
Marco Weigel
Steffen Gall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harro Hofliger Verpackungsmaschinen GmbH
Original Assignee
Harro Hofliger Verpackungsmaschinen GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harro Hofliger Verpackungsmaschinen GmbH filed Critical Harro Hofliger Verpackungsmaschinen GmbH
Priority to EP20156171.9A priority Critical patent/EP3861974B1/de
Priority to CA3106489A priority patent/CA3106489A1/en
Priority to US17/168,839 priority patent/US20210244617A1/en
Priority to CN202110160117.6A priority patent/CN113244110A/zh
Publication of EP3861974A1 publication Critical patent/EP3861974A1/de
Application granted granted Critical
Publication of EP3861974B1 publication Critical patent/EP3861974B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/074—Filling capsules; Related operations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/072—Sealing capsules, e.g. rendering them tamper-proof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B5/00—Cleaning by methods involving the use of air flow or gas flow
    • B08B5/04—Cleaning by suction, with or without auxiliary action

Definitions

  • the invention relates to a capsule closing device for closing two-part capsules with the features according to the preamble of claim 1.
  • capsules are used, in the interior of which active substance preparations or the like are filled.
  • Such capsules are designed in two parts and consist of a lower capsule part and an upper capsule part attached thereto.
  • Common capsule materials are hard gelatine, HPMC (hydroxypropyl methyl cellulose) or the like.
  • Empty capsules are delivered for filling in a loosely assembled state and fed to a capsule closing device.
  • This comprises a capsule upper part receptacle and a capsule lower part receptacle, with the loosely assembled empty capsule first coming to rest in the capsule upper part receptacle. Proceeding from this, the lower capsule part is pulled out of the upper capsule part, for example by means of a vacuum, and inserted into the lower capsule part receptacle. The capsule bottom part is filled in the capsule bottom part receptacle. After this, the lower capsule part is pressed, for example by means of a stamp, to receive the upper capsule part and is inserted there into the upper capsule part.
  • the capsule bottom of the capsule base can also tear or break when it hits the capsule base receptacle. Since high forces are also required when closing the capsule, the base can be dented or even break by the punch acting on the base of the lower part of the capsule.
  • the invention is based on the object of further developing a generic capsule closing device in such a way that its operational reliability is increased.
  • the capsule closing device is based on the consideration that the necessary high forces for separating and closing the capsule are based on a lack of pressure equalization.
  • the capsule shell receptacle has at least one ventilation groove on its inside.
  • the ventilation groove extends from the receiving bore to the insertion bore.
  • the capsule shell receptacle preferably has at least two, in particular three, ventilation grooves on its inside.
  • the lower capsule part that is finally detached is sucked into the lower capsule part receptacle with less force, as a result of which capsule cracking or other damage to the capsule can be avoided.
  • the resulting alternating impulse when the pressure is equalized is also only very small, so that an unintentional ejection of the upper part of the capsule from the upper part of the capsule can be avoided.
  • the pressure equalization also takes place when the capsule is closed.
  • the volume of the interior space between the lower capsule part and the upper capsule part is reduced.
  • the excess air escapes through the ventilation groove, which avoids overpressure when the capsule is closed. Accordingly, no excess pressure counteracts the closing force on the lower part of the capsule.
  • the forces can be reduced when closing the capsule, so that any damage to the capsule due to excessive closing forces can be avoided.
  • the receiving bore of the upper part of the capsule preferably extends from a first longitudinal end to a second longitudinal end on the support shoulder, the at least one venting groove running from the insertion bore to the first longitudinal end of the receiving bore.
  • the first longitudinal end of the receiving bore corresponds to an insertion area with an insertion bevel for threading in the capsule.
  • the insertion area tapers in the direction from the first longitudinal end to the second longitudinal end.
  • the support shoulder of the capsule closing device typically has a peripheral inner edge.
  • the at least one ventilation groove advantageously forms an interruption in this inner edge. Accordingly, the interruption of the inner edge is located exactly at the position at which the capsule upper part and the capsule lower part overlap in the closed state. If the lower part of the capsule is pulled out of the upper part of the capsule, the pressure in the interior can be equalized at the earliest possible point in time when the lower part of the capsule and the upper part of the capsule no longer overlap. When closing the capsule, the pressure can equalize take place over as long a period of time as possible until the lower part of the capsule and the upper part of the capsule overlap again and define an airtight interior space.
  • the capsule closing device preferably comprises a suction device for sucking off dust particles on the capsule.
  • the suction device can preferably be connected to the ventilation groove.
  • the support shoulder is formed by an annular groove in the receiving bore for receiving unwanted filling material.
  • the receiving bore preferably comprises a second longitudinal section adjoining the annular groove and a first longitudinal section adjoining the second longitudinal section.
  • the first longitudinal section of the receiving bore preferably forms a constriction for clamping the upper part of the capsule.
  • the capsule pushed into the receiving bore is held clamped on the capsule upper part by the constriction of the second section.
  • the constriction is designed in such a way that the clamping forces are sufficiently high to prevent the upper part of the capsule from jumping when the capsule is separated and closed, and the capsule can still be ejected intentionally without damaging it.
  • the receiving bore to have a clamping diameter at the constriction, the clamping diameter being smaller than a base diameter of the second longitudinal section.
  • the constriction of the receiving bore is formed by this clamping diameter, which is smaller than the base diameter.
  • the base diameter is preferably constant over the entire second longitudinal section.
  • the clamping diameter is advantageously larger than the diameter of the receiving bore on the support shoulder.
  • the clamping diameter at the constriction is sufficiently small to keep the cap clamped.
  • the Clamping diameter is still sufficiently large that such strong compression that the capsule upper part slips past the support shoulder into the insertion bore can be avoided.
  • the corresponding lower capsule bushing can also have a constriction with a combination of base diameter and clamping diameter.
  • the ratio of the clamping diameter to the base diameter is about 0.97 on the capsule top bushing and about 0.96 on the capsule bottom bushing.
  • An independent idea that is also inventive consists in providing the aforementioned capsule closing device only with the aforementioned constriction instead of a ventilation groove.
  • FIG. 1 shows a schematic, partially sectioned representation of a two-part capsule 20, as used for example in the pharmaceutical sector or in the field of food supplements, and which contains an active ingredient preparation in the filled state.
  • a two-part capsule 20 When filled and closed, it is intended to be swallowed by one person.
  • Various materials such as hard gelatine, HPMC or the like come into consideration as the capsule material, which dissolves after swallowing and releases the capsule contents.
  • the two-part capsule 20 is composed of a capsule shell 21 and a capsule shell 22, wherein the capsule shell 22 with a base nominal diameter du is inserted into the open side of the capsule shell 21 with a larger shell nominal diameter D O .
  • the upper part 21 of the capsule consists of a conventional design of a hemispherical cap 23 which is adjoined by a cylinder section 24 .
  • the capsule upper part 21 is delimited on its open side by a circumferential capsule edge 25 of the cylinder section 24 .
  • the lower capsule part 22 is constructed analogously to the upper capsule part 21 and consists of a hemispherical cap 26 to which a cylinder section 27 is connected.
  • the lower capsule part 22 On its side facing the upper capsule part 21 and inserted there, the lower capsule part 22 is delimited by a circumferential capsule edge 28 of the cylinder section 27, with when the upper capsule part 21 and lower capsule part 22 are plugged together, part of the cylindrical section 27 together with its circumferential capsule edge 28 is inside the cylindrical section 24 of the upper capsule part 21 comes to rest.
  • FIG. 2 shows a capsule closing device 1 according to the invention in a longitudinal sectional view, which comprises a capsule upper part receptacle 2 and a capsule lower part receptacle 3 .
  • a capsule closing arrangement with a capsule upper part 21 and a capsule lower part 22 of a capsule 20 is arranged.
  • the upper capsule part receptacle 2 has a receiving bore 4 for receiving the upper capsule part 21 and transitions in the direction of the lower capsule part receptacle 3 into a coaxially arranged insertion bore 5 .
  • the diameter of the insertion bore 5 is reduced compared to the diameter of the receiving bore 4 so that at the transition between the receiving bore 4 and the insertion bore 5 a circumferential support shoulder 6 is formed.
  • the support shoulder 6 delimits the receiving bore 4 at the bottom and, like the insertion bore 5 , is narrowed in relation to the receiving bore 4 .
  • the capsule 20 is inserted into the capsule shell receptacle 2 according to the arrow 12 in such a way that the capsule shell 21 comes to rest with its cylinder section 24 in the receiving bore 5, while the circumferential capsule edge 25 of the capsule shell 21 rests on the support shoulder 6.
  • the support shoulder 6 has an inner diameter that is reduced compared to the receiving bore 4, through which the lower capsule part 22 can be passed.
  • the capsule base receptacle 3 is positioned coaxially and includes a receptacle bore 13.
  • the capsule base 22 protruding into the insertion bore 5 is pulled out of the capsule cap 21 into the receptacle bore 13 of the capsule base receptacle 3 in the direction of arrow 12, for example by means of a vacuum or the like it comes to rest with its downward-pointing spherical cap 26 on a shoulder 14 that is reduced in diameter compared to the receiving bore 13 .
  • the cylinder section 27 of the lower capsule part 22 is supported by the peripheral wall of the receiving bore 14 .
  • the lower capsule part 22 is filled with the active ingredient preparation, not shown, while it is held in the lower capsule part receptacle 3 .
  • the capsule 20 is closed by means of the capsule closing device 1, in that the lower capsule part 21 is pressed upwards through the receiving bore 14 and the insertion bore 5 into the upper capsule part 21, for example by means of a stamp (not shown) in the opposite direction of the arrow 12.
  • a counterforce is exerted on the upper capsule part 21 in order to fix it spatially in the direction of the arrow 12, for example by means of a stamp, which is also not shown.
  • the circumferential capsule edge 28 of the lower capsule part 22 slides radially inside the circumferential capsule edge 25 of the upper capsule part 21 into its cylinder section 24 .
  • the receiving bore 4 extends along a longitudinal axis 16 of the capsule shell receptacle 2 from a first longitudinal end 30 to a second longitudinal end 31.
  • the receiving bore 4 can be divided in the direction of arrow 12 into a plurality of sections in the appropriate order, namely the first longitudinal end 30, a longitudinal section 32 and the second longitudinal end 31.
  • the first longitudinal end 30 of the receiving bore 4 is formed by an insertion region 35 with an insertion bevel 36 for threading the capsule 20 in.
  • the insertion area 36 tapers in the direction of the arrow 12 and transitions into the longitudinal section 34 .
  • the longitudinal section 34 extends to the second end 31 of the receiving bore 4, the receiving bore 4 being cylindrical along the longitudinal section 34 and having a constant diameter D 1 .
  • the second end 31 is formed by a circumferential annular groove 29 on the inside 11 of the capsule shell receptacle 2 .
  • the annular groove 29 serves to accommodate any filling material that has escaped undesirably.
  • a support shoulder 6 is formed on the annular groove 29 , the support shoulder 6 having a shoulder diameter D A which is smaller than the diameter D 1 of the receiving bore 4 on the longitudinal section 34 .
  • the insertion bore 5 Adjacent to the support shoulder 6 is the insertion bore 5 , which extends in the direction of the longitudinal axis 16 of the capsule shell receptacle 2 up to the end 37 of the bore. At the end 37 of the bore, the insertion bore 5 widens again like a funnel in the direction of the arrow 12, as a result of which the threading of the lower capsule part 22 into the insertion bore 5 is promoted after the filling process.
  • a plurality of ventilation grooves 9 are formed on the capsule upper part receptacle 2 .
  • the preferred embodiment of the capsule shell receptacle 2 has three ventilation grooves 9 ( 4 ).
  • the formation of a single ventilation groove 9 can already be expedient.
  • the upper capsule part 21 lies flush with its capsule edge 25 on the inside 11 of the receiving bore 4 . If the lower capsule part 22 is pulled out of the upper capsule part 22 , the capsule edge 28 of the lower capsule part 22 is also flush with the inside 11 of the insertion bore 5 .
  • the upper capsule part 21 and lower capsule part 22 delimit an interior space 15 .
  • the ventilation groove 9 enables an exchange of air between the interior space 15 and the environment outside of the upper capsule part receptacle 2 . Consequently, when the capsule 20 is separated and closed, a pressure equalization takes place, so that an underpressure or overpressure present in the interior space 15 can be avoided.
  • the ventilation groove 9 is formed on the inside 11 of the capsule shell receptacle 2 . As in 3 shown, the venting groove 9 runs from the insertion bore 5 to the receiving bore 4. In the exemplary embodiment, the venting groove 9 extends from the insertion bore 5 to the first longitudinal end 30 of the receiving bore 4. Accordingly, the venting groove 9 runs to the insertion area 35 of the receiving bore 4. Since the insertion area 35 has the insertion bevel 36, the capsule shell is 21 in Insertion area 35 not on the inside 11. Thus, the ventilation groove 9 in the insertion area 35 is not closed by the capsule 20, as a result of which the pressure can be equalized with the environment.
  • the venting groove 9 extends only into the longitudinal section 34. This applies when the longitudinal section 34 of the receiving bore 4 extends over a particularly wide longitudinal area in the direction of the longitudinal axis 16 .
  • the venting groove 9 should then extend at least so far into the receiving bore 4 that the end 38 of the venting groove 9 facing away from the supporting shoulder 6 is at a distance a from the supporting shoulder 6 that corresponds at least to the diameter D 1 of the receiving bore 4 on the longitudinal section 34.
  • the venting groove 9 runs through the support shoulder 6 and thereby forms an interruption 8 in the essentially circumferential inner edge 7 of the support shoulder 8.
  • the interruption 8 in the inner edge 7 of the support shoulder 6 the capsule edge 25 of the capsule upper part 21 is not in airtight contact with the Support paragraph 6, which ensures the earliest possible pressure equalization.
  • the capsule shell receptacle 2 according to the embodiment of FIG 2 shown in a plan view.
  • the ventilation grooves 9 are distributed in the circumferential direction of the longitudinal axis 16 at a uniform angular spacing. Accordingly, in the exemplary embodiment 4 the angular spacing of the three ventilation grooves 9 is 120°. It can also be expedient to form the venting grooves 9 on the capsule shell receptacle 2 at an uneven angular spacing in the circumferential direction of the longitudinal axis 16 .
  • the ventilation groove 9 extends in the circumferential direction of the longitudinal axis 16 over a width which corresponds to an angular range ⁇ of at least 15°, preferably at least 30°, advantageously approximately over 40°.
  • the ventilation groove 9 has a depth b measured radially to the longitudinal axis 16 , which corresponds to a range of 2 to 10% of the diameter D 1 of the receiving bore 4 on the longitudinal section 34 .
  • the depth b of the ventilation groove 9 is approximately 6% of the diameter D 1 .
  • the ventilation grooves 9 are preferably of the same design.
  • the ventilation grooves 9 can be produced, for example, by drilling, milling, or eroding.
  • FIG 5 a further embodiment variant of the capsule closing device 1 is shown, which differs from the exemplary embodiment 3 differs only in an additional constriction 40 for clamping the capsule upper part 21 in the receiving bore 4.
  • the longitudinal section 34 of the receiving bore 4 shown in the previous embodiment is divided into a first longitudinal section 32 and a second longitudinal section 33 adjoining it.
  • the first longitudinal section 32 thus runs from the first longitudinal end 30 to the second longitudinal section 33, with the second longitudinal section 33 at the second longitudinal end 31 adjacent.
  • the receiving bore 4 includes a constriction 40 for clamping the capsule upper part 21.
  • the constriction 40 is formed in the first longitudinal section 32 of the receiving bore 4.
  • the constriction 40 is formed by reducing the cross section of the receiving bore 4 .
  • the first longitudinal section 32 has a clamping diameter D K that is smaller than a base diameter D G of the second longitudinal section 33.
  • the clamping diameter D K corresponds to the smallest diameter in the first longitudinal section 32.
  • the receiving bore 4 is cylindrical in the second longitudinal section 33. Therefore, the base diameter D G of the second longitudinal section 33 is constant. In an alternative embodiment, it can be expedient not to construct the second longitudinal section in a cylindrical manner.
  • the clamping diameter D K of the first longitudinal section 34 is smaller than each diameter in the second longitudinal section 33.
  • the clamping diameter D K at the constriction 40 is less than the outside diameter of the capsule cap 21, so that the capsule cap 21 is clamped by the constriction 40.
  • the constriction 40 is formed near the first longitudinal end 30 of the receiving bore 4, since compression of the capsule edge 25 of the capsule upper part 21 is avoided. This is necessary in order to ensure reliable support of the capsule shell 21 on the support shoulder 6 and to secure the capsule shell 21 against slipping through the insertion bore 5 . Therefore, the constriction 40 is on the upper longitudinal half, i.e. the longitudinal half of the receiving bore 4 facing away from the supporting shoulder 6.
  • the clamping diameter D K is larger than the diameter D A of the receiving bore 4 on the supporting shoulder 6.
  • the capsule closing device 1 can have an in 2 include only schematically indicated suction device 17.
  • the suction device 17 is connected to the one or more ventilation grooves 9 and is primarily used to suck off dust particles adhering to the capsule 20 .
  • the suction device 17 is only switched on when the capsule 20 is already closed again after the filling process. This prevents the capsule contents from being sucked out of the lower capsule part 3 by the suction device 17 .
  • the suction device 17 can also be used to clean the capsule shell receptacle 2 of dust particles that settle on the inside 11 of the capsule shell receptacle 2, for example.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
EP20156171.9A 2020-02-07 2020-02-07 Kapselverschliesseinrichtung zum verschliessen zweiteiliger kapseln Active EP3861974B1 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP20156171.9A EP3861974B1 (de) 2020-02-07 2020-02-07 Kapselverschliesseinrichtung zum verschliessen zweiteiliger kapseln
CA3106489A CA3106489A1 (en) 2020-02-07 2021-01-18 Capsule closure device for closing two-piece capsules
US17/168,839 US20210244617A1 (en) 2020-02-07 2021-02-05 Capsule closure device for closing two-piece capsules
CN202110160117.6A CN113244110A (zh) 2020-02-07 2021-02-05 用于将两件式的胶囊封闭的胶囊封闭装置

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP20156171.9A EP3861974B1 (de) 2020-02-07 2020-02-07 Kapselverschliesseinrichtung zum verschliessen zweiteiliger kapseln

Publications (2)

Publication Number Publication Date
EP3861974A1 EP3861974A1 (de) 2021-08-11
EP3861974B1 true EP3861974B1 (de) 2023-06-07

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Family Applications (1)

Application Number Title Priority Date Filing Date
EP20156171.9A Active EP3861974B1 (de) 2020-02-07 2020-02-07 Kapselverschliesseinrichtung zum verschliessen zweiteiliger kapseln

Country Status (4)

Country Link
US (1) US20210244617A1 (zh)
EP (1) EP3861974B1 (zh)
CN (1) CN113244110A (zh)
CA (1) CA3106489A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113729499A (zh) * 2021-09-29 2021-12-03 无锡鼎加弘思饮品科技有限公司 一种导流装置

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Also Published As

Publication number Publication date
CA3106489A1 (en) 2021-08-07
EP3861974A1 (de) 2021-08-11
CN113244110A (zh) 2021-08-13
US20210244617A1 (en) 2021-08-12

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