EP3818369A4 - METHODS OF MEASURING HEMATOCRITY IN FLUID CHANNELS INCLUDING A CONDUCTIVITY SENSOR - Google Patents

METHODS OF MEASURING HEMATOCRITY IN FLUID CHANNELS INCLUDING A CONDUCTIVITY SENSOR Download PDF

Info

Publication number
EP3818369A4
EP3818369A4 EP19831195.3A EP19831195A EP3818369A4 EP 3818369 A4 EP3818369 A4 EP 3818369A4 EP 19831195 A EP19831195 A EP 19831195A EP 3818369 A4 EP3818369 A4 EP 3818369A4
Authority
EP
European Patent Office
Prior art keywords
methods
conductivity sensor
channels including
fluidic channels
measuring hematocrit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19831195.3A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP3818369A1 (en
Inventor
James Russell Webster
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Qorvo US Inc
Original Assignee
Qorvo US Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Qorvo US Inc filed Critical Qorvo US Inc
Priority claimed from PCT/US2019/039465 external-priority patent/WO2020009896A1/en
Publication of EP3818369A1 publication Critical patent/EP3818369A1/en
Publication of EP3818369A4 publication Critical patent/EP3818369A4/en
Pending legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/4875—Details of handling test elements, e.g. dispensing or storage, not specific to a particular test method
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F1/00—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow
    • G01F1/56—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using electric or magnetic effects
    • G01F1/58—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using electric or magnetic effects by electromagnetic flowmeters
    • G01F1/584—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using electric or magnetic effects by electromagnetic flowmeters constructions of electrodes, accessories therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
    • G01N27/06—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a liquid
    • G01N27/08—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a liquid which is flowing continuously
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/02—Analysing fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/02—Analysing fluids
    • G01N29/022—Fluid sensors based on microsensors, e.g. quartz crystal-microbalance [QCM], surface acoustic wave [SAW] devices, tuning forks, cantilevers, flexural plate wave [FPW] devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/02—Analysing fluids
    • G01N29/036—Analysing fluids by measuring frequency or resonance of acoustic waves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/22—Details, e.g. general constructional or apparatus details
    • G01N29/222—Constructional or flow details for analysing fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0663—Whole sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0672—Integrated piercing tool
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0289—Apparatus for withdrawing or distributing predetermined quantities of fluid
    • B01L3/0293—Apparatus for withdrawing or distributing predetermined quantities of fluid for liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50855—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates using modular assemblies of strips or of individual wells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/025—Change of phase or condition
    • G01N2291/0255—(Bio)chemical reactions, e.g. on biosensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/025—Change of phase or condition
    • G01N2291/0256—Adsorption, desorption, surface mass change, e.g. on biosensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/04—Wave modes and trajectories
    • G01N2291/042—Wave modes
    • G01N2291/0426—Bulk waves, e.g. quartz crystal microbalance, torsional waves

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Acoustics & Sound (AREA)
  • Clinical Laboratory Science (AREA)
  • Ecology (AREA)
  • Dispersion Chemistry (AREA)
  • Electromagnetism (AREA)
  • Fluid Mechanics (AREA)
  • Electrochemistry (AREA)
  • Optics & Photonics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
EP19831195.3A 2018-07-06 2019-06-27 METHODS OF MEASURING HEMATOCRITY IN FLUID CHANNELS INCLUDING A CONDUCTIVITY SENSOR Pending EP3818369A4 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201862694594P 2018-07-06 2018-07-06
US201862694621P 2018-07-06 2018-07-06
US201862694599P 2018-07-06 2018-07-06
US16/120,225 US11541385B2 (en) 2018-07-06 2018-09-01 Methods of measuring hematocrit in fluidic channels including conductivity sensor
US16/120,224 US11344878B2 (en) 2018-07-06 2018-09-01 Fluidic channels including conductivity sensor and methods of use thereof
PCT/US2019/039465 WO2020009896A1 (en) 2018-07-06 2019-06-27 Methods of measuring hematocrit in fluidic channels including conductivity sensor

Publications (2)

Publication Number Publication Date
EP3818369A1 EP3818369A1 (en) 2021-05-12
EP3818369A4 true EP3818369A4 (en) 2022-03-30

Family

ID=69101990

Family Applications (2)

Application Number Title Priority Date Filing Date
EP19831195.3A Pending EP3818369A4 (en) 2018-07-06 2019-06-27 METHODS OF MEASURING HEMATOCRITY IN FLUID CHANNELS INCLUDING A CONDUCTIVITY SENSOR
EP19831197.9A Pending EP3818370A4 (en) 2018-07-06 2019-06-27 CONDUCTIVITY SENSOR FLUID CHANNELS AND METHODS OF USE THEREOF

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP19831197.9A Pending EP3818370A4 (en) 2018-07-06 2019-06-27 CONDUCTIVITY SENSOR FLUID CHANNELS AND METHODS OF USE THEREOF

Country Status (4)

Country Link
US (5) US11541385B2 (zh)
EP (2) EP3818369A4 (zh)
JP (2) JP7434266B2 (zh)
CN (2) CN112384796A (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11541385B2 (en) 2018-07-06 2023-01-03 Qorvo Us, Inc. Methods of measuring hematocrit in fluidic channels including conductivity sensor

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4547735A (en) * 1982-01-23 1985-10-15 Holger Kiesewetter Instrument for measuring the hematocrit value of blood
GB2501128A (en) * 2012-04-13 2013-10-16 Phillip J Ainger Resistance measurements across first and second electrode pairs to determine glucose and packed cell volume respectively
WO2013153406A1 (en) * 2012-04-13 2013-10-17 Smartcare Technologies Limited Electrical impedance hematocrit and hba1c biosensor comprising sample plate and sample apparatus
WO2014190295A2 (en) * 2013-05-23 2014-11-27 Rapid Diagnostek Two part assembly

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6058934A (en) 1995-11-02 2000-05-09 Chiron Diagnostics Corporation Planar hematocrit sensor incorporating a seven-electrode conductivity measurement cell
US5869971A (en) * 1996-05-17 1999-02-09 Sendx Medical, Inc. Method and apparatus for ratiometric measurement of hematocrit
WO2001049414A2 (en) 2000-01-06 2001-07-12 Caliper Technologies Corp. Ultra high throughput sampling and analysis systems and methods
US7955559B2 (en) * 2005-11-15 2011-06-07 Nanomix, Inc. Nanoelectronic electrochemical test device
US6794877B2 (en) * 2002-07-31 2004-09-21 International Technidyne Corporation Apparatus and method for analytical determinations
JP4643921B2 (ja) * 2004-03-26 2011-03-02 独立行政法人科学技術振興機構 流路における流体の通過を検出する方法および流体の流れを制御する方法
JP2006167706A (ja) * 2004-04-09 2006-06-29 Toto Ltd イオン水生成装置
JP4500733B2 (ja) * 2005-05-30 2010-07-14 株式会社日立ハイテクノロジーズ 化学分析装置
US20080297169A1 (en) 2007-05-31 2008-12-04 Greenquist Alfred C Particle Fraction Determination of A Sample
US8158430B1 (en) * 2007-08-06 2012-04-17 Theranos, Inc. Systems and methods of fluidic sample processing
JP2009276275A (ja) * 2008-05-16 2009-11-26 Panasonic Corp 測定デバイス及びそれを用いた測定方法
ES2588703T3 (es) * 2009-12-07 2016-11-04 Meso Scale Technologies, Llc. Un cartucho de ensayo
TWI440853B (zh) * 2009-12-14 2014-06-11 Taidoc Technology Corp 具有校正血容比功能之分析物測量電化學生物感測試紙、生物感測器裝置、系統以及測量方法
US8877034B2 (en) * 2009-12-30 2014-11-04 Lifescan, Inc. Systems, devices, and methods for measuring whole blood hematocrit based on initial fill velocity
KR20110080067A (ko) 2010-01-04 2011-07-12 엘지전자 주식회사 샘플분석 카트리지 및 샘플분석 카트리지 리더
CA2824404C (en) * 2011-01-06 2023-01-03 Meso Scale Technologies, Llc Assay cartridges for pcr analysis and methods of use thereof
US9081001B2 (en) * 2012-05-15 2015-07-14 Wellstat Diagnostics, Llc Diagnostic systems and instruments
KR101466222B1 (ko) * 2012-06-01 2014-12-01 주식회사 아이센스 정확도가 향상된 전기화학적 바이오센서
CN104937404A (zh) * 2013-01-17 2015-09-23 田中贵金属工业株式会社 生物传感器及其制造方法
WO2014160513A1 (en) 2013-03-13 2014-10-02 Feingold Joseph Microfluidic analyte detection cartridge device, system and method
WO2014140178A1 (en) * 2013-03-15 2014-09-18 Roche Diagnostics Gmbh Methods of electrochemically measuring an analyte with a test sequence having a pulsed dc block as well as devices, apparatuses and systems incorporating the same
EP3000133B1 (en) 2013-05-23 2021-01-20 Qorvo US, Inc. Piezoelectric sensor
JP6449994B2 (ja) * 2014-05-23 2019-01-09 ノヴァ バイオメディカル コーポレイション 溶血検出方法およびシステム
CN107110875A (zh) 2014-09-26 2017-08-29 雅培医护站股份有限公司 用在凝固测定中的鞣花酸制剂
US10114031B2 (en) * 2014-09-26 2018-10-30 Abbott Point Of Care Inc. Single channel cartridge device for coagulation assays in fluid samples
WO2017195038A1 (en) * 2016-05-13 2017-11-16 Smith & Nephew Plc Sensor enabled wound monitoring and therapy apparatus
US11541385B2 (en) 2018-07-06 2023-01-03 Qorvo Us, Inc. Methods of measuring hematocrit in fluidic channels including conductivity sensor

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4547735A (en) * 1982-01-23 1985-10-15 Holger Kiesewetter Instrument for measuring the hematocrit value of blood
GB2501128A (en) * 2012-04-13 2013-10-16 Phillip J Ainger Resistance measurements across first and second electrode pairs to determine glucose and packed cell volume respectively
WO2013153406A1 (en) * 2012-04-13 2013-10-17 Smartcare Technologies Limited Electrical impedance hematocrit and hba1c biosensor comprising sample plate and sample apparatus
WO2014190295A2 (en) * 2013-05-23 2014-11-27 Rapid Diagnostek Two part assembly

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2020009896A1 *

Also Published As

Publication number Publication date
US11541385B2 (en) 2023-01-03
US20230234045A1 (en) 2023-07-27
US20220241769A1 (en) 2022-08-04
EP3818369A1 (en) 2021-05-12
US20230133768A1 (en) 2023-05-04
JP7434266B2 (ja) 2024-02-20
EP3818370A4 (en) 2022-03-30
US20200011849A1 (en) 2020-01-09
US11344878B2 (en) 2022-05-31
JP2021529965A (ja) 2021-11-04
JP2021529325A (ja) 2021-10-28
CN112469998A (zh) 2021-03-09
US20200011825A1 (en) 2020-01-09
CN112384796A (zh) 2021-02-19
US11612887B2 (en) 2023-03-28
EP3818370A1 (en) 2021-05-12

Similar Documents

Publication Publication Date Title
EP3446113A4 (en) NANOPORE SENSOR, STRUCTURE AND DEVICE WITH THE SENSOR AND METHOD FOR SHAPING AND USE THEREOF
HK1252205A1 (zh) 使用光-酶分析物傳感器進行連續健康監測的系統和方法
EP3531910A4 (en) SYSTEMS AND METHODS FOR TRANSCUTANEAL ANALYZER SENSORS
EP3493737A4 (en) INTERNAL MEASURING SYSTEMS AND METHOD FOR BIOLOGICAL SIGNAL MONITORING
EP3399918A4 (en) SYSTEMS AND METHOD FOR DETERMINING CLINICAL INDICATIONS
EP3397142A4 (en) SYSTEMS AND METHOD FOR TRANSCUTANEOUS ANALYTIC SENSORS
EP3149465A4 (en) Electrochemical sensor for analyte detection
EP3662271A4 (en) SYSTEM FOR DETERMINING THE PRESENCE OF A SUBSTANCE OF INTEREST IN A SAMPLE
EP3467512A4 (en) SAMPLE PROCESSING AND MEASURING SYSTEM
EP3311140A4 (en) Determining extracellular analyte concentration with nanoplasmonic sensors
EP3534109A4 (en) METHOD AND SYSTEM FOR DEPTH MEASUREMENT
EP3742963A4 (en) CONTINUOUS BLOOD PRESSURE MEASUREMENT
EP3552006A4 (en) ELECTROCHEMICAL SENSORS AND METHOD OF USING THEREOF
EP3329093A4 (en) DETERMINATION OF CARBIDE PARAMETERS BY MEANS OF ULTRASONIC AND MICRO RESISTANCE TRANSDUCERS
EP3902468A4 (en) IMPEDANCE DETERMINING ANALYTE SENSOR
EP3312586A4 (en) Biological material measuring instrument
EP3149519A4 (en) Using an array of sensors between two transmitters in an eddy current logging environment
EP3424417A4 (en) BLOOD FLOW SENSOR AND BLOOD FLOW MEASURING DEVICE
EP3435076A4 (en) ELECTROCHEMICAL MEASURING METHOD, ELECTROCHEMICAL MEASURING DEVICE AND CONVERTER
EP3878359A4 (en) BIOLOGICAL ELECTRODE, BIOLOGICAL SENSOR AND BIOLOGICAL SIGNAL MEASUREMENT SYSTEM
EP3090252A4 (en) Methods and systems for the electrochemical detection of analytes
EP3134419A4 (en) Non-enzymatic electrochemical sensor for measuring analytes
EP3431917A4 (en) GAME SENSOR AND GAME MEASURING METHOD
EP3449245A4 (en) TEXTURED ELECTRODES WITH IMPROVED ELECTROCHEMICAL SENSITIVITY
EP3142553A4 (en) Systems and methods for measurement of oxygen levels in blood by placement of a single sensor on the skin

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20210106

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20220228

RIC1 Information provided on ipc code assigned before grant

Ipc: G01N 33/543 20060101ALI20220222BHEP

Ipc: G01N 29/22 20060101ALI20220222BHEP

Ipc: G01N 27/08 20060101ALI20220222BHEP

Ipc: B01L 3/02 20060101ALI20220222BHEP

Ipc: G01N 33/50 20060101ALI20220222BHEP

Ipc: G01N 33/49 20060101ALI20220222BHEP

Ipc: G01N 33/487 20060101ALI20220222BHEP

Ipc: G01N 29/036 20060101ALI20220222BHEP

Ipc: B01L 3/00 20060101ALI20220222BHEP

Ipc: G01N 29/02 20060101AFI20220222BHEP

P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20230505

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20240306