EP3780977A1 - Delivery vehicle - Google Patents
Delivery vehicleInfo
- Publication number
- EP3780977A1 EP3780977A1 EP19718845.1A EP19718845A EP3780977A1 EP 3780977 A1 EP3780977 A1 EP 3780977A1 EP 19718845 A EP19718845 A EP 19718845A EP 3780977 A1 EP3780977 A1 EP 3780977A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- delivery vehicle
- present
- thermoplastic polymer
- formulation
- porous substrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims abstract description 144
- 229920001169 thermoplastic Polymers 0.000 claims abstract description 141
- 238000009472 formulation Methods 0.000 claims abstract description 127
- 239000000758 substrate Substances 0.000 claims abstract description 126
- 239000000463 material Substances 0.000 claims abstract description 67
- 239000000443 aerosol Substances 0.000 claims abstract description 58
- 238000011068 loading method Methods 0.000 claims abstract description 28
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 99
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 99
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims description 49
- 229960002715 nicotine Drugs 0.000 claims description 49
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims description 49
- -1 y- undecalactone Chemical compound 0.000 claims description 36
- 239000000796 flavoring agent Substances 0.000 claims description 24
- 235000019634 flavors Nutrition 0.000 claims description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 239000004743 Polypropylene Substances 0.000 claims description 14
- 229920001155 polypropylene Polymers 0.000 claims description 10
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 9
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 9
- 229940041616 menthol Drugs 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
- 239000013543 active substance Substances 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 7
- 230000008569 process Effects 0.000 claims description 7
- 229920002292 Nylon 6 Polymers 0.000 claims description 5
- 239000004698 Polyethylene Substances 0.000 claims description 5
- 239000004793 Polystyrene Substances 0.000 claims description 5
- 239000004417 polycarbonate Substances 0.000 claims description 5
- 229920000139 polyethylene terephthalate Polymers 0.000 claims description 5
- 239000005020 polyethylene terephthalate Substances 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 5
- 244000043261 Hevea brasiliensis Species 0.000 claims description 4
- 229930040373 Paraformaldehyde Natural products 0.000 claims description 4
- 239000004696 Poly ether ether ketone Substances 0.000 claims description 4
- 239000004952 Polyamide Substances 0.000 claims description 4
- 239000004962 Polyamide-imide Substances 0.000 claims description 4
- 239000004697 Polyetherimide Substances 0.000 claims description 4
- 229920000265 Polyparaphenylene Polymers 0.000 claims description 4
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 claims description 4
- XECAHXYUAAWDEL-UHFFFAOYSA-N acrylonitrile butadiene styrene Chemical group C=CC=C.C=CC#N.C=CC1=CC=CC=C1 XECAHXYUAAWDEL-UHFFFAOYSA-N 0.000 claims description 4
- 239000004676 acrylonitrile butadiene styrene Substances 0.000 claims description 4
- 229920000122 acrylonitrile butadiene styrene Polymers 0.000 claims description 4
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 4
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 4
- 229920003052 natural elastomer Polymers 0.000 claims description 4
- 229920001194 natural rubber Polymers 0.000 claims description 4
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 4
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 4
- 229920002492 poly(sulfone) Polymers 0.000 claims description 4
- 229920002647 polyamide Polymers 0.000 claims description 4
- 229920002312 polyamide-imide Polymers 0.000 claims description 4
- 229920001230 polyarylate Polymers 0.000 claims description 4
- 229920000515 polycarbonate Polymers 0.000 claims description 4
- 229920002530 polyetherether ketone Polymers 0.000 claims description 4
- 229920001601 polyetherimide Polymers 0.000 claims description 4
- 229920000573 polyethylene Polymers 0.000 claims description 4
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 4
- 229920006324 polyoxymethylene Polymers 0.000 claims description 4
- 229920002223 polystyrene Polymers 0.000 claims description 4
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 4
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 4
- 239000004800 polyvinyl chloride Substances 0.000 claims description 4
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 4
- NFLGAXVYCFJBMK-RKDXNWHRSA-N (+)-isomenthone Natural products CC(C)[C@H]1CC[C@@H](C)CC1=O NFLGAXVYCFJBMK-RKDXNWHRSA-N 0.000 claims description 2
- RADIRXJQODWKGQ-HWKANZROSA-N 2-Ethoxy-5-(1-propenyl)phenol Chemical compound CCOC1=CC=C(\C=C\C)C=C1O RADIRXJQODWKGQ-HWKANZROSA-N 0.000 claims description 2
- NFLGAXVYCFJBMK-UHFFFAOYSA-N Menthone Chemical compound CC(C)C1CCC(C)CC1=O NFLGAXVYCFJBMK-UHFFFAOYSA-N 0.000 claims description 2
- 229930007503 menthone Natural products 0.000 claims description 2
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 claims description 2
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 claims description 2
- 235000012141 vanillin Nutrition 0.000 claims description 2
- 239000011148 porous material Substances 0.000 description 55
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 10
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 10
- 239000008188 pellet Substances 0.000 description 9
- 239000007788 liquid Substances 0.000 description 8
- 230000000717 retained effect Effects 0.000 description 8
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 5
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 5
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 5
- 239000000969 carrier Substances 0.000 description 5
- 239000001087 glyceryl triacetate Substances 0.000 description 5
- 235000013773 glyceryl triacetate Nutrition 0.000 description 5
- 150000002334 glycols Chemical class 0.000 description 5
- 239000004310 lactic acid Substances 0.000 description 5
- 235000014655 lactic acid Nutrition 0.000 description 5
- 239000000523 sample Substances 0.000 description 5
- 239000000600 sorbitol Substances 0.000 description 5
- 229960002622 triacetin Drugs 0.000 description 5
- 239000001069 triethyl citrate Substances 0.000 description 5
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 5
- 235000013769 triethyl citrate Nutrition 0.000 description 5
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 5
- 239000000654 additive Substances 0.000 description 4
- 239000003205 fragrance Substances 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 241000167854 Bourreria succulenta Species 0.000 description 3
- 244000061176 Nicotiana tabacum Species 0.000 description 3
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 3
- 230000000996 additive effect Effects 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 235000019693 cherries Nutrition 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- 229930195733 hydrocarbon Natural products 0.000 description 3
- 150000002430 hydrocarbons Chemical class 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 229920005862 polyol Polymers 0.000 description 3
- 150000003077 polyols Chemical class 0.000 description 3
- 150000005846 sugar alcohols Polymers 0.000 description 3
- 229920002301 cellulose acetate Polymers 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000010408 film Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000001953 sensory effect Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000004580 weight loss Effects 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000016257 Mentha pulegium Nutrition 0.000 description 1
- 235000004357 Mentha x piperita Nutrition 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 239000003571 electronic cigarette Substances 0.000 description 1
- 239000005038 ethylene vinyl acetate Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
- A24B15/165—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes comprising as heat source a carbon fuel or an oxidized or thermally degraded carbonaceous fuel, e.g. carbohydrates, cellulosic material
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
- A24F40/48—Fluid transfer means, e.g. pumps
- A24F40/485—Valves; Apertures
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
- A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
- A24B15/241—Extraction of specific substances
- A24B15/243—Nicotine
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
- A24B15/281—Treatment of tobacco products or tobacco substitutes by chemical substances the action of the chemical substances being delayed
- A24B15/282—Treatment of tobacco products or tobacco substitutes by chemical substances the action of the chemical substances being delayed by indirect addition of the chemical substances, e.g. in the wrapper, in the case
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
- A24B15/281—Treatment of tobacco products or tobacco substitutes by chemical substances the action of the chemical substances being delayed
- A24B15/283—Treatment of tobacco products or tobacco substitutes by chemical substances the action of the chemical substances being delayed by encapsulation of the chemical substances
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
- A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
- A24B15/32—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances by acyclic compounds
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/10—Devices using liquid inhalable precursors
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
- A24F40/42—Cartridges or containers for inhalable precursors
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F47/00—Smokers' requisites not otherwise provided for
Definitions
- the present disclosure relates to a delivery vehicle, containers in which are contained the delivery vehicle, and to electronic aerosol provision systems such as electronic aerosol delivery systems (e.g. e-cigarettes) incorporating said product.
- electronic aerosol delivery systems e.g. e-cigarettes
- Electronic vapour provision systems such as e-cigarettes generally contain a reservoir of liquid which is to be vaporised, typically containing nicotine.
- a heater is activated to vaporise a small amount of liquid, which is therefore inhaled by the user.
- the materials taught as being suitable for encapsulating the flavour include various known materials and are designed such that they release their flavour at a given temperature. However, materials which have high loadings of flavour or another functionalising component may suffer from depletion of the flavour or another functionalising component during storage.
- a delivery vehicle for functionalising an aerosol in proximity to the delivery vehicle, wherein the delivery vehicle comprises a porous substrate material comprising at least one porous thermoplastic polymer and at least one formulation held within the thermoplastic polymer, wherein the formulation comprises at least one functionalising component and the porous thermoplastic polymer has a formulation loading capacity of at least 30% w/w based on the porous substrate.
- the present invention further provides a contained delivery vehicle for functionalising an aerosol, the contained delivery vehicle comprising
- a delivery vehicle for functionalising an aerosol in proximity to the delivery vehicle comprises a porous substrate material comprising at least one porous thermoplastic polymer and at least one formulation held within the thermoplastic polymer, wherein the formulation comprises at least one functionalising component and the porous thermoplastic polymer has a formulation loading capacity of at least 30% w/w based on the porous substrate.
- the present invention further provides an aerosolisable product comprising
- a delivery vehicle for functionalising an aerosol in proximity to the delivery vehicle comprises a porous substrate material comprising at least one porous thermoplastic polymer and at least one formulation held within the thermoplastic polymer, wherein the formulation comprises at least one functionalising component and the porous thermoplastic polymer has a formulation loading capacity of at least 30% w/w based on the porous substrate.
- the present invention further provides a process for forming a functionalised aerosol, the process comprising
- a delivery vehicle for functionalising an aerosol in proximity to the delivery vehicle comprising a porous substrate material comprising at least one porous thermoplastic polymer and at least one formulation held within the thermoplastic polymer, wherein the formulation comprises at least one functionalising component and the porous thermoplastic polymer has a formulation loading capacity of at least 30% w/w based on the porous substrate ;
- the present invention further provides an electronic aerosol provision system comprising:
- a delivery vehicle for functionalising an aerosol in proximity to the delivery vehicle comprises a porous substrate material comprising at least one porous thermoplastic polymer and at least one formulation held within the thermoplastic polymer, wherein the formulation comprises at least one functionalising component and the porous thermoplastic polymer has a formulation loading capacity of at least 30% w/w based on the porous substrate .
- the present invention provides a delivery vehicle for functionalising an aerosol in proximity to the delivery vehicle, wherein the delivery vehicle comprises a porous substrate material comprising at least one porous thermoplastic polymer and at least one formulation held within the thermoplastic polymer, wherein the formulation comprises at least one functionalising component and the porous thermoplastic polymer has a formulation loading capacity of at least 30% w/w based on the porous substrate.
- delivery vehicle comprising a porous substrate material comprising at least one porous thermoplastic polymer which has a functionalising component loading capacity of at least 30% w/w
- appreciable amounts of functionalising component may be held within the thermoplastic polymer yet when the delivery vehicle is positioned within the airflow path of an aerosol which is to be functionalised the pressure drop across the delivery vehicle can be reduced.
- This is advantageous as it is possible for the user to add the delivery vehicle to an aerosol delivery device in order to functionalise the aerosol without affecting (or hardly affecting) the pressure drop across the delivery vehicle.
- the present invention provides a delivery vehicle having a porous substrate material comprising at least one porous thermoplastic polymer and at least one formulation held within the thermoplastic polymer, wherein the formulation comprises at least one functionalising component and the porous thermoplastic polymer has a formulation loading capacity of at least 30% w/w based on the porous substrate.
- the porous thermoplastic polymer may be any suitable thermoplastic polymer.
- the thermoplastic polymer is selected from acrylonitrile butadiene styrene, natural rubber, nylon 6, polyamide, polyamideimide, polyarylate, polycarbonate, polydimethyl siloxane, polyetheretherketone, polyetherimide, polyethersulphone, polyethylene, polyethylene terephthalate, polymethylmethacrylate, polyoxymethylene, polyphenylene sulphide, polypropylene, polystyrene, polysulphone, polytetrafluoroethylene, polyvinylchloride, and mixtures thereof.
- the thermoplastic polymer is at least polypropylene.
- Suitable polymers such as suitable polypropylene, may be delivered in any suitable physical form, for example they may be delivered in the form of pellets, powders, granules or films. Even when loaded with the functionalising component as described herein the thermoplastic polymer in the form of powder, pellets or granules remain dry and free flowing making them convenient for dosing and handling.
- the delivery vehicle comprises a first porous thermoplastic polymer and a second porous thermoplastic polymer, wherein the first thermoplastic polymer and the second thermoplastic polymer are different from each other.
- the first thermoplastic polymer is selected from acrylonitrile butadiene styrene, natural rubber, nylon 6, polyamide, polyamideimide, polyarylate, polycarbonate, polydimethyl siloxane, polyetheretherketone, polyetherimide, polyethersulphone, polyethylene, polyethylene terephthalate, polymethylmethacrylate, polyoxymethylene, polyphenylene sulphide, polypropylene, polystyrene, polysulphone, polytetrafluoroethylene, polyvinylchloride, and mixtures thereof.
- the first thermoplastic polymer is at least polypropylene.
- the second thermoplastic polymer is selected from acrylonitrile butadiene styrene, natural rubber, nylon 6, polyamide, polyamideimide, polyarylate, polycarbonate, polydimethyl siloxane, polyetheretherketone, polyetherimide, polyethersulphone, polyethylene, polyethylene terephthalate, polymethylmethacrylate, polyoxymethylene, polyphenylene sulphide, polypropylene, polystyrene, polysulphone, polytetrafluoroethylene, polyvinylchloride, and mixtures thereof.
- the second thermoplastic polymer is at least polypropylene.
- the at least one porous thermoplastic polymer of the present delivery vehicle may have a nominal pore size of from 0.01 to 1 pm.
- the porous thermoplastic polymer present in the delivery system consists of porous thermoplastic polymer having a nominal pore size of from 0.01 to 1 pm.
- the porous substrate material may be formed wholly or in part from thermoplastic polymer having a nominal pore size of from 0.01 to 1 pm.
- thermoplastic polymer having a nominal pore size of from 0.01 to 1 pm is present in an amount of at least 10 wt.% based on the porous substrate material.
- thermoplastic polymer having a nominal pore size of from 0.01 to 1 pm is present in an amount of at least 20 wt.% based on the porous substrate material.
- thermoplastic polymer having a nominal pore size of from 0.01 to 1 pm is present in an amount of at least 30 wt.% based on the porous substrate material. In one aspect thermoplastic polymer having a nominal pore size of from 0.01 to 1 pm is present in an amount of at least 40 wt.% based on the porous substrate material. In one aspect thermoplastic polymer having a nominal pore size of from 0.01 to 1 pm is present in an amount of at least 50 wt.% based on the porous substrate material. In one aspect thermoplastic polymer having a nominal pore size of from 0.01 to 1 pm is present in an amount of at least 60 wt.% based on the porous substrate material.
- thermoplastic polymer having a nominal pore size of from 0.01 to 1 pm is present in an amount of at least 70 wt.% based on the porous substrate material. In one aspect thermoplastic polymer having a nominal pore size of from 0.01 to 1 pm is present in an amount of at least 80 wt.% based on the porous substrate material. In one aspect thermoplastic polymer having a nominal pore size of from 0.01 to 1 pm is present in an amount of at least 90 wt.% based on the porous substrate material. In one aspect thermoplastic polymer having a nominal pore size of from 0.01 to 1 pm is present in an amount of at least 95 wt.% based on the porous substrate material.
- thermoplastic polymer having a nominal pore size of from 0.01 to 1 pm is present in an amount of at least 99 wt.% based on the porous substrate material.
- the porous substrate material consists essentially of thermoplastic polymer having a nominal pore size of from 0.01 to 1 pm.
- the porous substrate material consists of thermoplastic polymer having a nominal pore size of from 0.01 to 1 pm.
- the at least one thermoplastic polymer has a nominal pore size of from 0.01 to 0.9 pm. In one aspect the at least one thermoplastic polymer has a nominal pore size of from 0.01 to 0.8 pm. In one aspect the at least one thermoplastic polymer has a nominal pore size of from 0.01 to 0.7 pm. In one aspect the at least one thermoplastic polymer has a nominal pore size of from 0.01 to 0.6 pm. In one aspect the at least one thermoplastic polymer has a nominal pore size of from 0.01 to 0.5 pm. In one aspect the at least one thermoplastic polymer has a nominal pore size of from 0.01 to 0.4 pm. In one aspect the at least one thermoplastic polymer has a nominal pore size of from 0.01 to 0.3 pm. In one aspect the at least one thermoplastic polymer has a nominal pore size of from 0.05 to 0.3 pm. In one aspect the at least one thermoplastic polymer has a nominal pore size of from 0.1 to 0.3 pm.
- thermoplastic polymer present in the delivery system consists of thermoplastic polymer having a nominal pore size of from 0.01 to 0.9 pm. In one aspect thermoplastic polymer present in the delivery system consists of thermoplastic polymer having a nominal pore size of from 0.01 to 0.8 pm. In one aspect thermoplastic polymer present in the delivery system consists of thermoplastic polymer having a nominal pore size of from 0.01 to 0.7 pm. In one aspect thermoplastic polymer present in the delivery system consists of thermoplastic polymer having a nominal pore size of from 0.01 to 0.6 pm. In one aspect thermoplastic polymer present in the delivery system consists of thermoplastic polymer having a nominal pore size of from 0.01 to 0.5 pm.
- thermoplastic polymer present in the delivery system consists of thermoplastic polymer having a nominal pore size of from 0.01 to 0.4 pm. In one aspect thermoplastic polymer present in the delivery system consists of thermoplastic polymer having a nominal pore size of from 0.01 to 0.3 pm. In one aspect thermoplastic polymer present in the delivery system consists of thermoplastic polymer having a nominal pore size of from 0.05 to 0.3 pm. In one aspect thermoplastic polymer present in the delivery system consists of thermoplastic polymer having a nominal pore size of from 0.1 to 0.3 pm.
- the at least one porous thermoplastic polymer of the present delivery vehicle may have an average pore size of from 0.01 to 1 pm. Suitable methods for determining the average pore size include via scanning electron microscope.
- the at least one thermoplastic polymer has an average pore size of from 0.01 to 0.9 pm. In one aspect the at least one thermoplastic polymer has an average pore size of from 0.01 to 0.8 pm. In one aspect the at least one thermoplastic polymer has an average pore size of from 0.01 to 0.7 pm. In one aspect the at least one thermoplastic polymer has an average pore size of from 0.01 to 0.6 pm. In one aspect the at least one thermoplastic polymer has an average pore size of from 0.01 to 0.5 pm. In one aspect the at least one thermoplastic polymer has an average pore size of from 0.01 to 0.4 pm. In one aspect the at least one thermoplastic polymer has an average pore size of from 0.01 to 0.3 pm. In one aspect the at least one thermoplastic polymer has an average pore size of from 0.05 to 0.3 pm. In one aspect the at least one thermoplastic polymer has an average pore size of from 0.1 to 0.3 pm.
- thermoplastic polymer present in the delivery system consists of thermoplastic polymer having an average pore size of from 0.01 to 0.9 pm. In one aspect thermoplastic polymer present in the delivery system consists of thermoplastic polymer having an average pore size of from 0.01 to 0.8 pm. In one aspect thermoplastic polymer present in the delivery system consists of thermoplastic polymer having an average pore size of from 0.01 to 0.7 pm. In one aspect thermoplastic polymer present in the delivery system consists of thermoplastic polymer having an average pore size of from 0.01 to 0.6 pm. In one aspect thermoplastic polymer present in the delivery system consists of thermoplastic polymer having an average pore size of from 0.01 to 0.5 pm.
- thermoplastic polymer present in the delivery system consists of thermoplastic polymer having an average pore size of from 0.01 to 0.4 pm. In one aspect thermoplastic polymer present in the delivery system consists of thermoplastic polymer having an average pore size of from 0.01 to 0.3 pm. In one aspect thermoplastic polymer present in the delivery system consists of thermoplastic polymer having an average pore size of from 0.05 to 0.3 pm. In one aspect thermoplastic polymer present in the delivery system consists of thermoplastic polymer having an average pore size of from 0.1 to 0.3 pm.
- the porous substrate material may be present in any suitable amount to provide the desired aim of functionalising an aerosol.
- the porous substrate material is present in an amount of at least 0.2g. In one aspect, the porous substrate material is present in an amount of at least 0.3g. In one aspect, the porous substrate material is present in an amount of at least 0.4g. In one aspect, the porous substrate material is present in an amount of at least 0.5g. In one aspect, the porous substrate material is present in an amount of at least 0.6g. In one aspect, the porous substrate material is present in an amount of at least 0.7g. In one aspect, the porous substrate material is present in an amount of at least 0.8g. In one aspect, the porous substrate material is present in an amount of at least 0.9g. In one aspect, the porous substrate material is present in an amount of at least 1.0g. In one aspect, the porous substrate material is present in an amount of at least 1.5g. In one aspect, the porous substrate material is present in an amount of at least 2.0g.
- the porous substrate material is present in an amount of up to 10. Og. In one aspect, the porous substrate material is present in an amount of up to 9.0g. In one aspect, the porous substrate material is present in an amount of up to 8.0g. In one aspect, the porous substrate material is present in an amount of up to 7.0g. In one aspect, the porous substrate material is present in an amount of up to 6.0g. In one aspect, the porous substrate material is present in an amount of up to 5.0g. In one aspect, the porous substrate material is present in an amount of up to 4.0g. In one aspect, the porous substrate material is present in an amount of up to 3.0g. In one aspect, the porous substrate material is present in an amount of up to 2.9g.
- the porous substrate material is present in an amount of up to 2.8g. In one aspect, the porous substrate material is present in an amount of up to 2.7g. In one aspect, the porous substrate material is present in an amount of up to 2.6g. In one aspect, the porous substrate material is present in an amount of up to 2.5g.
- the functionalising component may be any material which modifies the nature of the aerosol with which it is contacted.
- the at least one functionalising component may be selected from flavour components, protonating components, active componentsand mixtures thereof.
- the at least one functionalising component is at least one flavour component.
- a flavoured component is a material which imparts a flavour to the aerosol.
- the at least one flavour component is selected from the group consisting of (4- (para-)methoxyphenyl)-2-butanone, vanillin, g-undecalactone, menthone, 5-propenyl guaethol, menthol, para-mentha-8-thiol-3-one and mixtures thereof.
- the at least one flavour component is at least menthol.
- the functionalising component may be solid or liquid. In one aspect the functionalising component is a solid at temperature of 40°C. In one aspect the functionalising component is a solid at temperature of 60°C. In one aspect, the functionalising component is a powder, such as a free flowing powder.
- the at least one functionalising component may be present in any suitable amount to provide the desired aim of functionalising an aerosol.
- the at least one functionalising component is present in an amount of at least 1 wt.% based on the porous substrate.
- the at least one functionalising component is present in an amount of at least 2 wt.% based on the porous substrate.
- the at least one functionalising component is present in an amount of at least 3 wt.% based on the porous substrate.
- the at least one functionalising component is present in an amount of at least 4 wt.% based on the porous substrate.
- the at least one functionalising component is present in an amount of at least 5 wt.% based on the porous substrate.
- the at least one functionalising component is present in an amount of at least 10 wt.% based on the porous substrate. In one aspect the at least one functionalising component is present in an amount of at least 15 wt.% based on the porous substrate. In one aspect the at least one functionalising component is present in an amount of at least 20 wt.% based on the porous substrate. In one aspect the at least one functionalising component is present in an amount of at least 25 wt.% based on the porous substrate. In one aspect the at least one functionalising component is present in an amount of at least 30 wt.% based on the porous substrate. In one aspect the at least one functionalising component is present in an amount of at least 40 wt.% based on the porous substrate.
- the at least one functionalising component is present in an amount of at least 50 wt.% based on the porous substrate. In one aspect the at least one functionalising component is present in an amount of at least 60 wt.% based on the porous substrate. In one aspect the at least one functionalising component is present in an amount of at least 70 wt.% based on the porous substrate. In one aspect the at least one functionalising component is present in an amount of at least 80 wt.% based on the porous substrate. In one aspect the at least one functionalising component is present in an amount of at least 90 wt.% based on the porous substrate.
- the at least one functionalising component is present in an amount of from 1 to 90 wt.% based on the porous substrate. In one aspect the at least one functionalising component is present in an amount of from 2 to 90 wt.% based on the porous substrate. In one aspect the at least one functionalising component is present in an amount of from 3 to 90 wt.% based on the porous substrate. In one aspect the at least one functionalising component is present in an amount of from 4 to 90 wt.% based on the porous substrate. In one aspect the at least one functionalising component is present in an amount of from 5 to 90 wt.% based on porous substrate.
- the at least one functionalising component is present in an amount of from 10 to 90 wt.% based on the porous substrate. In one aspect the at least one functionalising component is present in an amount of from 20 to 90 wt.% based on the porous substrate. In one aspect the at least one functionalising component is present in an amount of from 20 to 90 wt.% based on the porous substrate.
- the formulation comprises the functionalising component and a carrier.
- the carrier may be selected from water, polyhydric alcohols, such as glycerol, propylene glycol and triethylene glycol, for example, or esters such as triethyl citrate or triacetin, or high boiling point hydrocarbons, or non-polyols, such as glycols, sorbitol or lactic acid, for example.
- the carrier may be selected from polyhydric alcohols, such as glycerol, propylene glycol and triethylene glycol, for example, or esters such as triethyl citrate or triacetin, or high boiling point hydrocarbons, or non-polyols, such as glycols, sorbitol or lactic acid, for example.
- the carrier is selected from polyhydric alcohols (such as glycerol, propylene glycol and triethylene glycol), esters (such as triethyl citrate and triacetin), high boiling point hydrocarbons, non-polyols (such as glycols, sorbitol and lactic acid), and mixtures thereof.
- the carrier may be selected from water, triethylene glycol, triethyl citrate, triacetin, glycols, sorbitol, lactic acid, glycerol, propylene glycol, and mixtures thereof.
- the carrier may be selected from triethylene glycol, triethyl citrate, triacetin, glycols, sorbitol, lactic acid, glycerol, propylene glycol, and mixtures thereof.
- the carrier is selected from water, glycerol, propylene glycol, and mixtures thereof. In one aspect, the carrier is selected from glycerol, propylene glycol, and mixtures thereof. In one aspect, the carrier is a mixture of glycerol and propylene glycol.
- the one or more carriers may be present in any suitable amount in the formulation depending on the functionalising component. In one aspect the one or more carriers is present in a total amount of at least 1 wt.% based on the formulation. In one aspect the one or more carriers is present in a total amount of at least 2 wt.% based on the formulation. In one aspect the one or more carriersis present in a total amount of at least 5 wt.% based on the formulation. In one aspect the one or more carriersis present in a total amount of at least 10 wt.% based on the formulation. In one aspect the one or more carriersis present in a total amount of at least 20 wt.% based on the formulation.
- the one or more carriers is present in a total amount of at least 30 wt.% based on the formulation. In one aspect the one or more carriersis present in a total amount of at least 40 wt.% based on the formulation. In one aspect the one or more carriersis present in a total amount of at least 50 wt.% based on the formulation.
- the one or more carriers is present in a total amount of from 1 to 990 wt.% based on the formulation. In one aspect the one or more carriers is present in a total amount of from 2 to 50 wt.% based on the formulation. In one aspect the one or more carriersis present in a total amount of from 5 to 50 wt.% based on the formulation. In one aspect the one or more carriersis present in a total amount of from 10 to 50 wt.% based on the formulation. In one aspect the one or more carriersis present in a total amount of from 20to 50 wt.% based on the formulation. In one aspect the one or more carriersis present in a total amount of from 30 to 50 wt.% based on formulation.
- the carrier is at least glycerol.
- the glycerol may be present in any suitable amount in the formulation. In one aspect the glycerol is present in a total amount of at least 1 wt.% based on the formulation. In one aspect the glycerol is present in a total amount of at least 2 wt.% based on the formulation. In one aspect the glycerol is present in a total amount of at least 5 wt.% based on the formulation. In one aspect the glycerol is present in a total amount of at least 10 wt.% based on the formulation. In one aspect the glycerol is present in a total amount of at least 20 wt.% based on the formulation.
- the glycerol is present in a total amount of at least 30 wt.% based on the formulation. In one aspect the glycerol is present in a total amount of at least 40 wt.% based on the formulation. In one aspect the glycerol is present in a total amount of at least 50 wt.% based on the formulation.
- the glycerol is present in a total amount of from 1 to 99 wt.% based on the formulation. In one aspect the glycerol is present in a total amount of from 1 to 90 wt.% based on the formulation. In one aspect the glycerol is present in a total amount of from 1 to 80 wt.% based on the formulation. In one aspect the glycerol is present in a total amount of from 1 to 70 wt.% based on the formulation. In one aspect the glycerol is present in a total amount of from 1 to 60 wt.% based on the formulation. In one aspect the glycerol is present in a total amount of from 1 to 90 wt.% based on the formulation.
- the glycerol is present in a total amount of from 2 to 50 wt.% based on the formulation. In one aspect the glycerol is present in a total amount of from 5 to 50 wt.% based on the formulation. In one aspect the glycerol is present in a total amount of from 10 to 50 wt.% based on the formulation. In one aspect the glycerol is present in a total amount of from 20to 50 wt.% based on the formulation. In one aspect the glycerol is present in a total amount of from 30 to 50 wt.% based on the formulation.
- the carrier is at least propylene glycol.
- the propylene glycol may be present in any suitable amount in the formulation. In one aspect the propylene glycol is present in a total amount of at least 1 wt.% based on the formulation. In one aspect the propylene glycol is present in a total amount of at least 2 wt.% based on the formulation. In one aspect the propylene glycol is present in a total amount of at least 5 wt.% based on the formulation. In one aspect the propylene glycol is present in a total amount of at least 10 wt.% based on the formulation. In one aspect the propylene glycol is present in a total amount of at least 20 wt.% based on the formulation.
- the propylene glycol is present in a total amount of at least 30 wt.% based on the formulation. In one aspect the propylene glycol is present in a total amount of at least 40 wt.% based on the formulation. In one aspect the propylene glycol is present in a total amount of at least 50 wt.% based on the formulation.
- the propylene glycol is present in a total amount of from 1 to 99 wt.% based on the formulation. In one aspect the propylene glycol is present in a total amount of from 1 to 90 wt.% based on the formulation. In one aspect the propylene glycol is present in a total amount of from 1 to 80 wt.% based on the formulation. In one aspect the propylene glycol is present in a total amount of from 1 to 70 wt.% based on the formulation. In one aspect the propylene glycol is present in a total amount of from 1 to 60 wt.% based on the formulation. In one aspect the propylene glycol is present in a total amount of from 1 to 50 wt.% based on the formulation.
- the propylene glycol is present in a total amount of from 2 to 50 wt.% based on the formulation. In one aspect the propylene glycol is present in a total amount of from 5 to 50 wt.% based on the formulation. In one aspect the propylene glycol is present in a total amount of from 10 to 50 wt.% based on the formulation. In one aspect the propylene glycol is present in a total amount of from 20to 50 wt.% based on the formulation. In one aspect the propylene glycol is present in a total amount of from 30 to 50 wt.% based on the formulation.
- the carrier is at least water.
- the water may be present in any suitable amount in the formulation. In one aspect the water is present in a total amount of at least 1 wt.% based on the formulation. In one aspect the water is present in a total amount of at least 2 wt.% based on the formulation. In one aspect the water is present in a total amount of at least 5 wt.% based on the formulation. In one aspect the water is present in a total amount of at least 10 wt.% based on the formulation. In one aspect the water is present in a total amount of at least 20 wt.% based on the formulation. In one aspect the water is present in a total amount of at least 30 wt.% based on the formulation. In one aspect the water is present in a total amount of at least 40 wt.% based on the formulation. In one aspect the water is present in a total amount of at least 50 wt.% based on the formulation.
- the water is present in a total amount of from 1 to 50 wt.% based on the formulation. In one aspect the water is present in a total amount of from 2 to 50 wt.% based on the formulation. In one aspect the water is present in a total amount of from 5 to 50 wt.% based on the formulation. In one aspect the water is present in a total amount of from 10 to 50 wt.% based on the formulation. In one aspect the water is present in a total amount of from 20to 50 wt.% based on the formulation. In one aspect the water is present in a total amount of from 30 to 50 wt.% based on the formulation.
- the porous thermoplastic polymer has a formulation loading capacity of at least 30 wt.% based on the porous substrate. In one aspect the porous thermoplastic polymer has a formulation loading capacity of at least 40 wt.% based on the porous substrate. In one aspect the porous thermoplastic polymer has a formulation loading capacity of at least 50 wt.% based on the porous substrate. In one aspect the porous thermoplastic polymer has a formulation loading capacity of at least 60 wt.% based on the porous substrate. In one aspect the porous thermoplastic polymer has a formulation loading capacity of at least 70 wt.% based on the porous substrate. In one aspect the porous thermoplastic polymer has a formulation loading capacity of at least 80 wt.% based on the porous substrate.
- the delivery vehicle of the present invention may contain one or more further components, which may be present in the formulation, adhered to the porous substrate, or located elsewhere on the delivery vehicle. These components may be selected depending on the nature of the formulation.
- the delivery vehicle further comprises an active agent.
- active agent it is meant an agent which has a biological effect on a subject when the vapour is inhaled.
- the one or more active agents may be selected from nicotine, botanicals, and mixtures thereof.
- the one or more active agents may be of synthetic or natural origin.
- the active could be an extract from a botanical, such as from a plant in the tobacco family.
- An example active is nicotine.
- the active agent is at least nicotine. Nicotine may be provided at any suitable amount depending on the desired dosage to be inhaled by the user. In one aspect nicotine is present in an amount of no greater than 6 wt% based on the total weight of the delivery vehicle. In one aspect nicotine is present in an amount of from 0.4 to 6 wt% based on the total weight of the delivery vehicle. In one aspect nicotine is present in an amount of from 0.8 to 6 wt% based on the total weight of the delivery vehicle. In one aspect nicotine is present in an amount of from 1 to 6 wt% based on the total weight of the delivery vehicle. In one aspect nicotine is present in an amount of from 1.8 to 6 wt% based on the total weight of the delivery vehicle.
- nicotine is present in an amount of from 0.4 to 5 wt% based on the total weight of the delivery vehicle. In one aspect nicotine is present in an amount of from 0.8 to 5 wt% based on the total weight of the delivery vehicle. In one aspect nicotine is present in an amount of from 1 to 5 wt% based on the total weight of the delivery vehicle. In one aspect nicotine is present in an amount of from 1.8 to 5 wt% based on the total weight of the delivery vehicle. In one aspect nicotine is present in an amount of no greater than 4 wt% based on the total weight of the delivery vehicle. In one aspect nicotine is present in an amount of from 0.4 to 4 wt% based on the total weight of the delivery vehicle.
- nicotine is present in an amount of from 0.8 to 4 wt% based on the total weight of the delivery vehicle. In one aspect nicotine is present in an amount of from 1 to 4 wt% based on the total weight of the delivery vehicle. In one aspect nicotine is present in an amount of from 1.8 to 4 wt% based on the total weight of the delivery vehicle. In one aspect nicotine is present in an amount of no greater than 3 wt% based on the total weight of the delivery vehicle. In one aspect nicotine is present in an amount of from 0.4 to 3 wt% based on the total weight of the delivery vehicle. In one aspect nicotine is present in an amount of from 0.8 to 3 wt% based on the total weight of the delivery vehicle.
- nicotine is present in an amount of from 1 to 3 wt% based on the total weight of the delivery vehicle. In one aspect nicotine is present in an amount of from 1.8 to 3 wt% based on the total weight of the delivery vehicle. In one aspect nicotine is present in an amount of no greater than 1.9 wt% based on the total weight of the delivery vehicle. In one aspect nicotine is present in an amount of no greater than 1.8 wt% based on the total weight of the delivery vehicle. In one aspect nicotine is present in an amount of from 0.4 to 1.9 wt% based on the total weight of the delivery vehicle. In one aspect nicotine is present in an amount of from 0.4 to 1.8 wt% based on the total weight of the delivery vehicle.
- nicotine is present in an amount of from 0.5 to 1.9 wt% based on the total weight of the delivery vehicle. In one aspect nicotine is present in an amount of from 0.5 to 1.8 wt% based on the total weight of the delivery vehicle. In one aspect nicotine is present in an amount of from 0.8 to 1.9 wt% based on the total weight of the delivery vehicle. In one aspect nicotine is present in an amount of from 0.8 to 1.8 wt% based on the total weight of the delivery vehicle. In one aspect nicotine is present in an amount of from 1 to 1.9 wt% based on the total weight of the delivery vehicle. In one aspect nicotine is present in an amount of from 1 to 1.8 wt% based on the total weight of the delivery vehicle.
- nicotine is present in an amount of less than 1.9 wt% based on the total weight of the delivery vehicle. In one aspect nicotine is present in an amount of less than 1.8 wt% based on the total weight of the delivery vehicle. In one aspect nicotine is present in an amount of from 0.4 to less than 1.9 wt% based on the total weight of the delivery vehicle. In one aspect nicotine is present in an amount of from 0.4 to less than 1.8 wt% based on the total weight of the delivery vehicle. In one aspect nicotine is present in an amount of from 0.5 to less than 1.9 wt% based on the total weight of the delivery vehicle. In one aspect nicotine is present in an amount of from 0.5 to less than 1.8 wt% based on the total weight of the delivery vehicle.
- nicotine is present in an amount of from 0.8 to less than 1.9 wt% based on the total weight of the delivery vehicle. In one aspect nicotine is present in an amount of from 0.8 to less than 1.8 wt% based on the total weight of the delivery vehicle. In one aspect nicotine is present in an amount of from 1 to less than 1.9 wt% based on the total weight of the delivery vehicle. In one aspect nicotine is present in an amount of from 1 to less than 1.8 wt% based on the total weight of the delivery vehicle.
- the delivery vehicle generally comprises both the porous substrate and the formulation contained within the porous substrate.
- the porous substrate is generally held within a housing having a connection end and a mouthpiece end.
- the connection end attaches to an opening in the aerosol delivery device, and the mouthpiece end contains an outlet for the inhalation of aerosol that has been functionalised.
- the housing contains a cavity within which the porous substrate is retained.
- the porous substrate may be retained within the cavity so as to have a minimal influence on the pressure drop across the delivery vehicle.
- the porous substrate is retained within the cavity of the delivery vehicle such that the increase in pressure drop across the delivery vehicle relative to the delivery vehicle without any porous substrate is less than 20 mmH 2 0.
- the porous substrate is retained within the cavity of the delivery vehicle such that the increase in pressure drop across the delivery vehicle relative to the delivery vehicle without any porous substrate is less than 15 mmH 2 0.
- the porous substrate is retained within the cavity of the delivery vehicle such that the increase in pressure drop across the delivery vehicle relative to the delivery vehicle without any porous substrate is less than 10 mmH 2 0.
- the porous substrate is retained within the cavity of the delivery vehicle such that the increase in pressure drop across the delivery vehicle relative to the delivery vehicle without any porous substrate is less than 7.5 mmH 2 0. In one aspect, the porous substrate is retained within the cavity of the delivery vehicle such that the increase in pressure drop across the delivery vehicle relative to the delivery vehicle without any porous substrate is less than 5 mmH 2 0.
- the porous substrate can be retained within the cavity of the housing in various forms so as to minimise the increase in pressure drop.
- the porous substrate can take the form of pellets.
- the delivery vehicle may be supplied with the porous substrate without the formulation specifically impregnated into the porous substrate. Such an arrangement may allow users to functionalise the porous substrate themselves.
- the delivery vehicle of the present invention may comprise a housing or container.
- the housing is adapted to be removably attached to an aerosol delivery device, specifically, at a point along the airflow path of the aerosol delivery device.
- the present invention further provides a contained delivery vehicle for functionalising an aerosol, the contained delivery vehicle comprising (a) a housing/container; and (b) a delivery vehicle for functionalising an aerosol in proximity to the delivery vehicle, wherein the delivery vehicle comprises a porous substrate material comprising at least one porous thermoplastic polymer and at least one formulation held within the thermoplastic polymer, wherein the formulation comprises at least one functionalising component and the porous thermoplastic polymer has a formulation loading capacity of at least 30% w/w.
- the delivery vehicle may contain any of the above carriers as an aerosol forming material.
- an aerosol forming material distinct from the delivery vehicle may be provided.
- the present invention further provides an aerosolisable product comprising (a) an aerosol forming material; and (b) a delivery vehicle for functionalising an aerosol in proximity to the delivery vehicle, wherein the delivery vehicle comprises a porous substrate material comprising at least one porous thermoplastic polymer and at least one formulation held within the thermoplastic polymer, wherein the formulation comprises at least one functionalising component and the porous thermoplastic polymer has a formulation loading capacity of at least 30% w/w.
- the term“aerosolisable product” refers to a combination of one or more materials, at least one of which is capable of forming a condensation aerosol following heating to an appropriate temperature. Thus, it is not necessary for all components of the aerosolisable product of the present invention to be“aerosolised”.
- the present invention further provides a process for forming a functionalised aerosol, the process comprising
- a delivery vehicle for functionalising an aerosol in proximity to the delivery vehicle comprising a porous substrate material comprising at least one porous thermoplastic polymer and at least one formulation held within the thermoplastic polymer, wherein the formulation comprises at least one functionalising component and the porous thermoplastic polymer has a formulation loading capacity of at least 30% w/w;
- the process of the present invention may comprises additional steps either before the steps listed, after the steps listed or between one or more of the steps listed.
- the present invention further provides an electronic aerosol provision system comprising:
- a delivery vehicle for functionalising an aerosol in proximity to the delivery vehicle comprises a porous substrate material comprising at least one porous thermoplastic polymer and at least one formulation held within the thermoplastic polymer, wherein the formulation comprises at least one functionalising component and the porous thermoplastic polymer has a formulation loading capacity of at least 30% w/w.
- the aerosol delivery/generation device has an airflow path along which aerosol generated by the device flows.
- the delivery vehicle is located in airflow path. In one aspect, the delivery vehicle is located in airflow path such that the aerosol passes through the porous substrate.
- Accurel® MP/XP materials which are porous polymers.
- the MP and XP product lines are manufactured with different cell forming agents resulting in slightly different properties, such as porosity level, additive loading time and loading level .
- the products can be made using PP, PE, EVA, PS, PET, PA6 PA12, PC, PLA, SAN and PMNA. PVOH versions are also available.
- the Accurel® porous structure is capable of absorbing high amounts of liquid or low melting point additives. On mixing the additive penetrates the cell structure by capillary action resulting in a free flowing, dry, super concentrate.
- Sample 1 - 10g of Accurel MP100-PP (10g) was placed into glass jar and 23.1g of cherry fragrance or menthol added.
- the glass jar was secured with an aluminium lid on which a spindle had been attached.
- the spindle was attached to a chuck of a rotary stirrer set horizontally.
- the jar and contents were gently rolled for 2 hours at 44rpm (Caframo top stirrer, model BDC50) at room temperature, at which time all the liquid had entered the porous particles, giving a final dry free flowing product which was 70% fragrance/flavour by weight.
- Sample 2 - the method of preparation of sample 1 was repeated and menthol was replaced with 50%pepermint oil/50%menthol.
- thermoplastic polymer used in the present example was identified as being a very good material for producing a highly concentrated free flowing substrate containing a liquid flavour.
- the eTank Pro device has a detachable drip-tip (mouthpiece) and so it is possible to replace this with the delivery vehicle of the present invention.
- the delivery vehicle used in the example comprised Accurel MP100-PP (hemi-cylindrical prism pellets of approximately 2.75mm by 2.89mm by 1.69mm, the pellets having an average mass of 34.40 mg per pellet, based on the mass of 32 pellets. 15 to 20 pellets were loaded into a delivery vehicle mouthpiece sized similarly to the mouthpiece of eTankPro. The cylindrical cavity of the mouthpiece within which the pellets were held had a total volume of 655mm 3 . For comparison purposes, the same delivery vehicle mouthpiece was used without the porous substrate and with cellulose acetate in place of the porous substrate. Table 1
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Abstract
Description
Claims
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GBGB1806245.5A GB201806245D0 (en) | 2018-04-17 | 2018-04-17 | Delivery vehicle |
PCT/GB2019/051083 WO2019202311A1 (en) | 2018-04-17 | 2019-04-16 | Delivery vehicle |
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EP (1) | EP3780977A1 (en) |
JP (2) | JP7426013B2 (en) |
KR (1) | KR102631319B1 (en) |
CA (1) | CA3097293C (en) |
GB (1) | GB201806245D0 (en) |
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-
2018
- 2018-04-17 GB GBGB1806245.5A patent/GB201806245D0/en not_active Ceased
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2019
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GB201806245D0 (en) | 2018-05-30 |
KR102631319B1 (en) | 2024-01-29 |
JP2023120351A (en) | 2023-08-29 |
JP7426013B2 (en) | 2024-02-01 |
WO2019202311A1 (en) | 2019-10-24 |
RU2760123C1 (en) | 2021-11-22 |
JP2021518759A (en) | 2021-08-05 |
US20210120877A1 (en) | 2021-04-29 |
KR20200139821A (en) | 2020-12-14 |
CA3097293A1 (en) | 2019-10-24 |
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