JP7426013B2 - delivery vehicle - Google Patents

Description

field of invention

The present disclosure relates to electronic aerosol delivery systems, such as delivery vehicles, containers containing delivery vehicles, and electronic aerosol delivery systems (e.g., e-cigarettes) incorporating the products.

Background of the invention

Electronic vapor delivery systems, such as e-cigarettes, generally contain a reservoir of vaporized liquid, typically containing nicotine. When a user inhales with the device, a heater is activated to vaporize a small amount of liquid, which is then inhaled by the user.

The use of e-cigarettes in the UK is rapidly increasing, with estimates suggesting that approximately 3 million people in the UK currently use e-cigarettes.

Current inhalation products use a liquid that is wicked into a heater that produces an aerosol. The aerosol is inhaled by the user, resulting in a sensory experience similar to smoking a cigarette. Aerosols can also be used to deliver nicotine and/or flavor. Some inhalation products deliver nicotine but do not contain flavoring. Some deliver flavor but not nicotine. Some deliver both flavor and nicotine. Current e-cigarette formulations typically utilize glycerol and/or propylene glycol as the liquid. It is known that materials can be used in perfume delivery systems to retain perfume or another functionalized ingredient in the delivered aerosol to deliver a sensory effect. For example, in US Patent Application Publication No. 2005/0172976, perfume or another functionalized ingredient can be carried in perfume releasing additives such as beads, films or inclusion complexes. Materials taught to be suitable for encapsulating perfume include a variety of known materials that are designed to release the perfume at a predetermined temperature. However, materials with high loadings of perfume or other functionalized ingredients may suffer depletion of the perfume or other functionalized ingredient during storage.

In one embodiment, a delivery vehicle for functionalizing an aerosol proximate the delivery vehicle, the delivery vehicle comprising at least one porous thermoplastic polymer and at least one compound retained within the thermoplastic polymer. comprising a porous substrate material, the formulation includes at least one functionalized component, and the amount of the formulation retained within the porous thermoplastic polymer is at least 30% w/based on the porous substrate. A delivery vehicle is provided which is w.

The present invention is a packaged delivery vehicle for functionalizing an aerosol comprising:
(a) a container; and (b) a delivery vehicle for functionalizing an aerosol proximate the delivery vehicle, the delivery vehicle comprising at least one porous thermoplastic polymer and at least one porous thermoplastic polymer retained within the thermoplastic polymer. a porous substrate material comprising a blend, the blend comprising at least one functionalized component, and the amount of the blend retained within the porous thermoplastic polymer is based on the porous substrate. Further provided is a packaged delivery vehicle comprising a delivery vehicle that is at least 30% w/w.

The present invention
(a) an aerosol-forming material; and (b) a delivery vehicle for functionalizing an aerosol proximate the delivery vehicle, the delivery vehicle comprising at least one porous thermoplastic polymer and at least one porous thermoplastic polymer retained within the thermoplastic polymer. a porous substrate material comprising a blend of seeds, the blend comprising at least one functionalized component, and an amount of the blend retained within the porous thermoplastic polymer comprising a porous substrate material; Further provided is an aerosolizable product comprising a delivery vehicle that is on a basis of at least 30% w/w.

The present invention is a method for forming a functionalized aerosol comprising:
(a) a porous delivery vehicle for functionalizing an aerosol proximate the delivery vehicle, the delivery vehicle comprising at least one porous thermoplastic polymer and at least one compound retained within the thermoplastic polymer; the formulation includes at least one functionalized component, and the amount of the formulation retained within the porous thermoplastic polymer is at least 30% w/w based on the porous substrate. and (b) positioning an aerosol proximate the delivery vehicle.

The present invention
(a) an aerosol generating device; and (b) a delivery vehicle for functionalizing an aerosol proximate the delivery vehicle, the delivery vehicle comprising at least one porous thermoplastic polymer and at least one porous thermoplastic polymer retained within the thermoplastic polymer. a porous substrate material comprising a blend of seeds, the blend comprising at least one functionalized component, and an amount of the blend retained within the porous thermoplastic polymer comprising a porous substrate material; Further provided is an electronic aerosol delivery system comprising a delivery vehicle that is on a basis of at least 30% w/w.

detailed description

As discussed herein, the present invention provides a delivery vehicle for functionalizing an aerosol proximate to the delivery vehicle comprising at least one porous thermoplastic polymer and at least one porous thermoplastic polymer retained within the thermoplastic polymer. a porous substrate material comprising one formulation, the formulation comprising at least one functionalized component, and an amount of the formulation retained within the porous thermoplastic polymer; Provided is a delivery vehicle that is at least 30% w/w based on.

By using a delivery vehicle comprising a porous substrate material comprising at least one porous thermoplastic polymer with a functionalized component loading capacity of at least 30% w/w, we have achieved a significant amount of functionality. Although the functionalized component can be retained within the thermoplastic polymer, we have found that when the delivery vehicle is placed within the airflow path of the aerosol to be functionalized, the pressure drop across the delivery vehicle can be reduced. This is because it allows the user to add delivery vehicle to the aerosol delivery device to functionalize the aerosol without (or with little to no effect on) the pressure drop across the delivery vehicle. It's advantageous. Users of aerosol delivery devices such as e-cigarettes are sensitive to pressure drops across the device during inhalation, so they do not provide a significant (if any) additional pressure drop when placed in the aerosol airflow path. It is advantageous to provide a delivery vehicle.

For ease of reference, these and further aspects of the invention are now discussed under appropriate section headings. However, the teachings of each section are not necessarily limited to each particular section.

Porous base material

As discussed herein, the present invention includes a porous substrate material that includes at least one porous thermoplastic polymer and at least one blend retained within the thermoplastic polymer, wherein the blend provides a delivery vehicle that includes at least one functionalized component and wherein the amount of formulation retained within the porous thermoplastic polymer is at least 30% w/w based on the porous substrate.

The porous thermoplastic polymer may be any suitable thermoplastic polymer. In one embodiment, the thermoplastic polymer is acrylonitrile butadiene styrene, natural rubber, nylon 6, polyamide, polyamideimide, polyarylate, polycarbonate, polydimethylsiloxane, polyetheretherketone, polyetherimide, polyethersulfone, polyethylene, polyethylene terephthalate. , polymethyl methacrylate, polyoxymethylene, polyphenylene sulfide, polypropylene, polystyrene, polysulfone, polytetrafluoroethylene, polyvinyl chloride, and mixtures thereof. In one embodiment, the thermoplastic polymer is at least polypropylene. Suitable polymers such as suitable polypropylene may be supplied in any suitable physical form, for example they may be supplied in the form of pellets, powders, granules or films. Even when loaded with functionalized ingredients as described herein, the thermoplastic polymer in powder, pellet or granule form remains dry and free-flowing, convenient for pouring and handling.

In one aspect, the delivery vehicle includes a first porous thermoplastic polymer and a second porous thermoplastic polymer, the first thermoplastic polymer and the second thermoplastic polymer being different from each other. In one embodiment, the first thermoplastic polymer is acrylonitrile butadiene styrene, natural rubber, nylon 6, polyamide, polyamideimide, polyarylate, polycarbonate, polydimethylsiloxane, polyetheretherketone, polyetherimide, polyethersulfone, polyethylene , polyethylene terephthalate, polymethyl methacrylate, polyoxymethylene, polyphenylene sulfide, polypropylene, polystyrene, polysulfone, polytetrafluoroethylene, polyvinyl chloride, and mixtures thereof. In one embodiment, the first thermoplastic polymer is at least polypropylene. In one embodiment, the second thermoplastic polymer is acrylonitrile butadiene styrene, natural rubber, nylon 6, polyamide, polyamideimide, polyarylate, polycarbonate, polydimethylsiloxane, polyetheretherketone, polyetherimide, polyethersulfone, polyethylene , polyethylene terephthalate, polymethyl methacrylate, polyoxymethylene, polyphenylene sulfide, polypropylene, polystyrene, polysulfone, polytetrafluoroethylene, polyvinyl chloride, and mixtures thereof. In one embodiment, the second thermoplastic polymer is at least polypropylene.

The at least one porous thermoplastic polymer of the delivery vehicle may have a nominal pore size of 0.01 to 1 μm. In one embodiment, the porous thermoplastic polymer present in the delivery system consists of a porous thermoplastic polymer having a nominal pore size of 0.01-1 μm.

The porous substrate material may be formed, in whole or in part, from a thermoplastic polymer with a nominal pore size of 0.01 to 1 μm. In one embodiment, the thermoplastic polymer having a nominal pore size of 0.01 to 1 μm is at least 10 wt. Present in an amount of %. In one embodiment, the thermoplastic polymer having a nominal pore size of 0.01 to 1 μm is at least 20 wt. Present in an amount of %. In one embodiment, the thermoplastic polymer having a nominal pore size of 0.01 to 1 μm is at least 30 wt. Present in an amount of %. In one embodiment, the thermoplastic polymer having a nominal pore size of 0.01 to 1 μm is at least 40 wt. Present in an amount of %. In one embodiment, the thermoplastic polymer having a nominal pore size of 0.01 to 1 μm is at least 50 wt. Present in an amount of %. In one embodiment, the thermoplastic polymer having a nominal pore size of 0.01 to 1 μm is at least 60 wt. Present in an amount of %. In one embodiment, the thermoplastic polymer having a nominal pore size of 0.01 to 1 μm is at least 70 wt. Present in an amount of %. In one embodiment, the thermoplastic polymer having a nominal pore size of 0.01 to 1 μm is at least 80 wt. Present in an amount of %. In one embodiment, the thermoplastic polymer having a nominal pore size of 0.01 to 1 μm is at least 90 wt. Present in an amount of %. In one embodiment, the thermoplastic polymer having a nominal pore size of 0.01 to 1 μm is at least 95 wt. Present in an amount of %. In one embodiment, the thermoplastic polymer having a nominal pore size of 0.01 to 1 μm is at least 99 wt. Present in an amount of %. In one embodiment, the porous substrate material consists essentially of a thermoplastic polymer having a nominal pore size of 0.01-1 μm. In one embodiment, the porous substrate material consists of a thermoplastic polymer with a nominal pore size of 0.01-1 μm.

In one embodiment, the at least one thermoplastic polymer has a nominal pore size of 0.01-0.9 μm. In one embodiment, the at least one thermoplastic polymer has a nominal pore size of 0.01-0.8 μm. In one embodiment, the at least one thermoplastic polymer has a nominal pore size of 0.01-0.7 μm. In one embodiment, the at least one thermoplastic polymer has a nominal pore size of 0.01-0.6 μm. In one embodiment, the at least one thermoplastic polymer has a nominal pore size of 0.01-0.5 μm. In one embodiment, the at least one thermoplastic polymer has a nominal pore size of 0.01-0.4 μm. In one embodiment, the at least one thermoplastic polymer has a nominal pore size of 0.01-0.3 μm. In one embodiment, the at least one thermoplastic polymer has a nominal pore size of 0.05-0.3 μm. In one embodiment, the at least one thermoplastic polymer has a nominal pore size of 0.1-0.3 μm.

In one embodiment, the thermoplastic polymer present in the delivery system consists of a thermoplastic polymer having a nominal pore size of 0.01-0.9 μm. In one embodiment, the thermoplastic polymer present in the delivery system consists of a thermoplastic polymer having a nominal pore size of 0.01-0.8 μm. In one embodiment, the thermoplastic polymer present in the delivery system consists of a thermoplastic polymer having a nominal pore size of 0.01-0.7 μm. In one embodiment, the thermoplastic polymer present in the delivery system consists of a thermoplastic polymer having a nominal pore size of 0.01-0.6 μm. In one embodiment, the thermoplastic polymer present in the delivery system consists of a thermoplastic polymer having a nominal pore size of 0.01-0.5 μm. In one embodiment, the thermoplastic polymer present in the delivery system consists of a thermoplastic polymer having a nominal pore size of 0.01-0.4 μm. In one embodiment, the thermoplastic polymer present in the delivery system consists of a thermoplastic polymer having a nominal pore size of 0.01-0.3 μm. In one embodiment, the thermoplastic polymer present in the delivery system consists of a thermoplastic polymer having a nominal pore size of 0.05-0.3 μm. In one embodiment, the thermoplastic polymer present in the delivery system consists of a thermoplastic polymer having a nominal pore size of 0.1-0.3 μm.

In one embodiment, the at least one porous thermoplastic polymer of the delivery vehicle may have an average pore size of 0.01-1 μm. A suitable method for determining the average pore size includes a method using a scanning electron microscope.

In one embodiment, the at least one thermoplastic polymer has an average pore size of 0.01-0.9 μm. In one embodiment, the at least one thermoplastic polymer has an average pore size of 0.01-0.8 μm. In one embodiment, the at least one thermoplastic polymer has an average pore size of 0.01-0.7 μm. In one embodiment, the at least one thermoplastic polymer has an average pore size of 0.01-0.6 μm. In one embodiment, the at least one thermoplastic polymer has an average pore size of 0.01-0.5 μm. In one embodiment, the at least one thermoplastic polymer has an average pore size of 0.01-0.4 μm. In one embodiment, the at least one thermoplastic polymer has an average pore size of 0.01-0.3 μm. In one embodiment, the at least one thermoplastic polymer has an average pore size of 0.05-0.3 μm. In one embodiment, the at least one thermoplastic polymer has an average pore size of 0.1-0.3 μm.

In one embodiment, the thermoplastic polymer present in the delivery system consists of a thermoplastic polymer having an average pore size of 0.01-0.9 μm. In one embodiment, the thermoplastic polymer present in the delivery system consists of a thermoplastic polymer having an average pore size of 0.01-0.8 μm. In one embodiment, the thermoplastic polymer present in the delivery system consists of a thermoplastic polymer having an average pore size of 0.01-0.7 μm. In one embodiment, the thermoplastic polymer present in the delivery system consists of a thermoplastic polymer having an average pore size of 0.01-0.6 μm. In one embodiment, the thermoplastic polymer present in the delivery system consists of a thermoplastic polymer having an average pore size of 0.01-0.5 μm. In one embodiment, the thermoplastic polymer present in the delivery system consists of a thermoplastic polymer having an average pore size of 0.01-0.4 μm. In one embodiment, the thermoplastic polymer present in the delivery system consists of a thermoplastic polymer having an average pore size of 0.01-0.3 μm. In one embodiment, the thermoplastic polymer present in the delivery system consists of a thermoplastic polymer having an average pore size of 0.05-0.3 μm. In one embodiment, the thermoplastic polymer present in the delivery system consists of a thermoplastic polymer having an average pore size of 0.1-0.3 μm.

The porous substrate material may be present in any suitable amount to achieve the desired purpose of functionalizing the aerosol. In one embodiment, the porous substrate material is present in an amount of at least 0.2 g. In one embodiment, the porous substrate material is present in an amount of at least 0.3g. In one embodiment, the porous substrate material is present in an amount of at least 0.4 g. In one embodiment, the porous substrate material is present in an amount of at least 0.5 g. In one embodiment, the porous substrate material is present in an amount of at least 0.6 g. In one embodiment, the porous substrate material is present in an amount of at least 0.7 g. In one embodiment, the porous substrate material is present in an amount of at least 0.8 g. In one embodiment, the porous substrate material is present in an amount of at least 0.9g. In one embodiment, the porous substrate material is present in an amount of at least 1.0 g. In one embodiment, the porous substrate material is present in an amount of at least 1.5 g. In one embodiment, the porous substrate material is present in an amount of at least 2.0 g.

In one embodiment, the porous substrate material is present in an amount of up to 10.0 g. In one embodiment, the porous substrate material is present in an amount of up to 9.0 g. In one embodiment, the porous substrate material is present in an amount of up to 8.0 g. In one embodiment, the porous substrate material is present in an amount of up to 7.0 g. In one embodiment, the porous substrate material is present in an amount of up to 6.0 g. In one embodiment, the porous substrate material is present in an amount of up to 5.0 g. In one embodiment, the porous substrate material is present in an amount of up to 4.0 g. In one embodiment, the porous substrate material is present in an amount of up to 3.0 g. In one embodiment, the porous substrate material is present in an amount of up to 2.9g. In one embodiment, the porous substrate material is present in an amount of up to 2.8 g. In one embodiment, the porous substrate material is present in an amount of up to 2.7 g. In one embodiment, the porous substrate material is present in an amount of up to 2.6 g. In one embodiment, the porous substrate material is present in an amount of up to 2.5 g.

Functional component

The functionalizing component may be any material that modifies the properties of the aerosol it contacts. In one embodiment, the at least one functionalized ingredient may be selected from perfume ingredients, protonated ingredients, active ingredients, and mixtures thereof. In one embodiment, the at least one functionalized ingredient is at least one perfume ingredient. The fragrance component is a material that imparts a fragrance to the aerosol. In one embodiment, the at least one fragrance ingredient is (4-(para-)methoxyphenyl)-2-butanone, vanillin, γ-undecalactone, menthone, 5-propenylguaetol, menthol, para-menthol. 8-thiol-3-one, and mixtures thereof. In one embodiment, the at least one perfume ingredient is at least menthol.

The functionalized component may be solid or liquid. In one embodiment, the functionalized component is solid at a temperature of 40°C. In one embodiment, the functionalized component is solid at a temperature of 60°C. In one embodiment, the functionalized component is a powder, such as a free-flowing powder.

The at least one functionalizing component may be present in any suitable amount to achieve the desired purpose of functionalizing the aerosol. In one embodiment, the at least one functionalized component is at least 1 wt.% based on the porous substrate. Present in an amount of %. In one embodiment, the at least one functionalized component is at least 2 wt.% based on the porous substrate. Present in an amount of %. In one embodiment, the at least one functionalized component is at least 3 wt.% based on the porous substrate. Present in an amount of %. In one embodiment, the at least one functionalized component is at least 4 wt.% based on the porous substrate. Present in an amount of %. In one embodiment, the at least one functionalized component is at least 5 wt.% based on the porous substrate. Present in an amount of %. In one embodiment, the at least one functionalized component is at least 10 wt.% based on the porous substrate. Present in an amount of %. In one embodiment, the at least one functionalized component is at least 15 wt.% based on the porous substrate. Present in an amount of %. In one embodiment, the at least one functionalized component is at least 20 wt.% based on the porous substrate. Present in an amount of %. In one embodiment, the at least one functionalized component is at least 25 wt.% based on the porous substrate. Present in an amount of %. In one embodiment, the at least one functionalized component is at least 30 wt.% based on the porous substrate. Present in an amount of %. In one embodiment, the at least one functionalized component is at least 40 wt.% based on the porous substrate. Present in an amount of %. In one embodiment, the at least one functionalized component is at least 50 wt.% based on the porous substrate. Present in an amount of %. In one embodiment, the at least one functionalized component is at least 60 wt.% based on the porous substrate. Present in an amount of %. In one embodiment, the at least one functionalized component is at least 70 wt.% based on the porous substrate. Present in an amount of %. In one embodiment, the at least one functionalized component is at least 80 wt.% based on the porous substrate. Present in an amount of %. In one embodiment, the at least one functionalized component is at least 90 wt.% based on the porous substrate. Present in an amount of %.

In one embodiment, the at least one functionalized component is from 1 to 90 wt.% based on the porous substrate. Present in an amount of %. In one embodiment, the at least one functionalized component is between 2 and 90 wt.% based on the porous substrate. Present in an amount of %. In one embodiment, the at least one functionalized component is from 3 to 90 wt.% based on the porous substrate. Present in an amount of %. In one embodiment, the at least one functionalized component is between 4 and 90 wt.% based on the porous substrate. Present in an amount of %. In one embodiment, the at least one functionalized component is 5 to 90 wt.% based on the porous substrate. Present in an amount of %. In one embodiment, the at least one functionalized component is present in an amount of 10 to 90 wt.% based on the porous substrate. Present in an amount of %. In one embodiment, the at least one functionalized component is 20 to 90 wt.% based on the porous substrate. Present in an amount of %. In one embodiment, the at least one functionalized component is 20 to 90 wt.% based on the porous substrate. Present in an amount of %.

In one embodiment, the formulation includes a functionalized component and a carrier. The carrier is selected from water, polyhydric alcohols such as glycerol, propylene glycol and triethylene glycol, or esters such as triethyl citrate or triacetin, or high boiling hydrocarbons, or non-polyols such as glycols, sorbitol or lactic acid. It's okay. The carrier may be selected from polyhydric alcohols such as glycerol, propylene glycol and triethylene glycol, or esters such as triethyl citrate or triacetin, or high boiling hydrocarbons, or non-polyols such as glycols, sorbitol or lactic acid. good. In one embodiment, carriers include polyhydric alcohols (such as glycerol, propylene glycol and triethylene glycol), esters (such as triethyl citrate and triacetin), high boiling hydrocarbons, non-polyols (such as glycols, sorbitol and lactic acid); selected from a mixture of

The carrier may be selected from water, triethylene glycol, triethyl citrate, triacetin, glycols, sorbitol, lactic acid, glycerol, propylene glycol, and mixtures thereof. The carrier may be selected from triethylene glycol, triethyl citrate, triacetin, glycols, sorbitol, lactic acid, glycerol, propylene glycol, and mixtures thereof.

In one embodiment, the carrier is selected from water, glycerol, propylene glycol, and mixtures thereof. In one embodiment, the carrier is selected from glycerol, propylene glycol, and mixtures thereof. In one embodiment, the carrier is a mixture of glycerol and propylene glycol.

Depending on the functionalized component, one or more carriers may be present in the formulation in any suitable amount. In one embodiment, the one or more carriers are at least 1 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the one or more carriers are at least 2 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the one or more carriers are at least 5 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the one or more carriers is at least 10 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the one or more carriers are at least 20 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the one or more carriers are at least 30 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the one or more carriers are at least 40 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the one or more carriers is at least 50 wt.% based on the formulation. Present in a total amount of %.

In one embodiment, the one or more carriers are 1 to 990 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the one or more carriers is 2 to 50 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the one or more carriers are 5 to 50 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the one or more carriers is 10 to 50 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the one or more carriers is 20 to 50 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the one or more carriers is 30 to 50 wt.% based on the formulation. Present in a total amount of %.

As discussed herein, in one embodiment the carrier is at least glycerol. Glycerol may be present in the formulation in any suitable amount. In one embodiment, the glycerol is at least 1 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the glycerol is at least 2 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the glycerol is at least 5 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the glycerol is at least 10 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the glycerol is at least 20 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the glycerol is at least 30 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the glycerol is at least 40 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the glycerol is at least 50 wt.% based on the formulation. Present in a total amount of %.

In one embodiment, the glycerol is 1 to 99 wt. based on the formulation. Present in a total amount of %. In one embodiment, the glycerol is 1 to 90 wt. based on the formulation. Present in a total amount of %. In one embodiment, the glycerol is 1 to 80 wt. based on the formulation. Present in a total amount of %. In one embodiment, the glycerol is 1 to 70 wt. based on the formulation. Present in a total amount of %. In one embodiment, the glycerol is 1 to 60 wt. Present in a total amount of %. In one embodiment, the glycerol is 1 to 90 wt. based on the formulation. Present in a total amount of %. In one embodiment, the glycerol is 2 to 50 wt. based on the formulation. Present in a total amount of %. In one embodiment, the glycerol is on a formulation basis. 5-50wt. Present in a total amount of %. In one embodiment, the glycerol is 10 to 50 wt. based on the formulation. Present in a total amount of %. In one embodiment, the glycerol is 20 to 50 wt. Present in a total amount of %. In one embodiment, the glycerol is 30-50 wt. Present in a total amount of %.

As discussed herein, in one embodiment the carrier is at least propylene glycol. Propylene glycol may be present in the formulation in any suitable amount. In one embodiment, the propylene glycol is at least 1 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the propylene glycol is at least 2 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the propylene glycol is at least 5 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the propylene glycol is at least 10 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the propylene glycol is at least 20 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the propylene glycol is at least 30 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the propylene glycol is at least 40 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the propylene glycol is at least 50 wt.% based on the formulation. Present in a total amount of %.

In one embodiment, the propylene glycol is 1 to 99 wt. based on the formulation. Present in a total amount of %. In one embodiment, the propylene glycol is 1 to 90 wt. Present in a total amount of %. In one embodiment, the propylene glycol is 1 to 80 wt. based on the formulation. Present in a total amount of %. In one embodiment, the propylene glycol is 1 to 70 wt. based on the formulation. Present in a total amount of %. In one embodiment, the propylene glycol is 1 to 60 wt. based on the formulation. Present in a total amount of %. In one embodiment, the propylene glycol is 1 to 50 wt. based on the formulation. Present in a total amount of %. In one embodiment, the propylene glycol is 2 to 50 wt. based on the formulation. Present in a total amount of %. In one embodiment, the propylene glycol is 5 to 50 wt. Present in a total amount of %. In one embodiment, the propylene glycol is 10 to 50 wt. Present in a total amount of %. In one embodiment, the propylene glycol is 20 to 50 wt. based on the formulation. Present in a total amount of %. In one embodiment, the propylene glycol is 30-50 wt. based on the formulation. Present in a total amount of %.

As discussed herein, in one embodiment the carrier is at least water. Water may be present in the formulation in any suitable amount. In one embodiment, the water is at least 1 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the water is at least 2 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the water is at least 5 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the water is at least 10 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the water is at least 20 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the water is at least 30 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the water is at least 40 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the water is at least 50 wt.% based on the formulation. Present in a total amount of %.

In one embodiment, the water is 1 to 50 wt.% based on the formulation. Present in a total amount of %. In one embodiment, the water is 2 to 50 wt.wt. based on the formulation. Present in a total amount of %. In one embodiment, the water is 5 to 50 wt.wt. based on the formulation. Present in a total amount of %. In one embodiment, the water is 10 to 50 wt. Present in a total amount of %. In one embodiment, the water is 20 to 50 wt.wt. based on the formulation. Present in a total amount of %. In one embodiment, the water is 30 to 50 wt.wt. based on the formulation. Present in a total amount of %.

The amount of formulation retained within the porous thermoplastic polymer is at least 30 wt.% based on the porous substrate. % . In one embodiment, the amount of formulation retained within the porous thermoplastic polymer is at least 40 wt. % . In one embodiment, the amount of formulation retained within the porous thermoplastic polymer is at least 50 wt.% based on the porous substrate. % . In one embodiment, the amount of formulation retained within the porous thermoplastic polymer is at least 60 wt.% based on the porous substrate. % . In one embodiment, the amount of formulation retained within the porous thermoplastic polymer is at least 70 wt.% based on the porous substrate. % . In one embodiment, the amount of formulation retained within the porous thermoplastic polymer is at least 80 wt. % .

Aerosolizable products

The delivery vehicles of the present invention may contain one or more additional ingredients, whether present in the formulation, attached to a porous substrate, or other components on the delivery vehicle. It can be located anywhere. These components may be selected depending on the nature of the formulation. In one embodiment, the delivery vehicle further comprises an active agent. "Active agent" means an agent that has a biological effect on a subject when the vapor is inhaled. The active agent or agents may be selected from nicotine, botanicals, and mixtures thereof. The active agent or agents may be synthetic or naturally derived. The active substance can also be an extract from botanical substances, such as plants of the tobacco family. An exemplary active substance is nicotine.

In one embodiment, the active agent is at least nicotine. Nicotine may be provided in any suitable amount depending on the desired dose to be inhaled by the user. In one embodiment, nicotine is present in an amount of 6 wt% or less based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount of 0.4-6 wt% based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount of 0.8-6 wt% based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount of 1-6 wt% based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount of 1.8-6 wt% based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount of 0.4-5 wt% based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount of 0.8-5 wt% based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount of 1-5 wt% based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount of 1.8-5 wt% based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount of 4 wt% or less based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount of 0.4-4 wt% based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount of 0.8-4 wt% based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount of 1-4 wt% based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount of 1.8-4 wt% based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount of 3 wt% or less based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount of 0.4-3 wt% based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount of. 0.8-3 wt% based on total weight of delivery vehicle. In one embodiment, nicotine is present in an amount of 1-3 wt% based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount of 1.8-3 wt% based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount of 1.9 wt% or less based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount of 1.8 wt% or less based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount of 0.4-1.9 wt% based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount of 0.4-1.8 wt% based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount of 0.5-1.9 wt% based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount of 0.5-1.8 wt% based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount of 0.8-1.9 wt% based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount of 0.8-1.8 wt% based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount of 1-1.9 wt% based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount of 1-1.8 wt% based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount less than 1.9 wt% based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount less than 1.8 wt% based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount of less than 0.4-1.9 wt% based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount of less than 0.4-1.8 wt% based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount of less than 0.5-1.9 wt% based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount of less than 0.5-1.8 wt% based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount of less than 0.8-1.9 wt% based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount of less than 0.8-1.8 wt% based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount less than 1-1.9 wt% based on the total weight of the delivery vehicle. In one embodiment, nicotine is present in an amount less than 1-1.8 wt% based on the total weight of the delivery vehicle.

delivery vehicle

As previously explained, delivery vehicles generally include both a porous substrate and a formulation contained within the porous substrate. In this regard, the porous substrate is generally held within a housing having a connecting end and a mouthpiece end. The connecting end is attached to an opening in the aerosol delivery device and the mouthpiece end includes an outlet for inhalation of the functionalized aerosol.

In one embodiment, the housing includes a cavity within which a porous substrate is retained. The porous substrate may be retained within the cavity such that it has minimal effect on the pressure drop across the delivery vehicle. In one embodiment, the porous substrate is retained within the cavity of the delivery vehicle such that the increase in pressure drop across the delivery vehicle is less than 20 mm _H2O compared to a delivery vehicle without the porous substrate. In one aspect, the porous substrate is retained within the cavity of the delivery vehicle such that the increase in pressure drop across the delivery vehicle is less than 15 mm _H2O compared to a delivery vehicle without the porous substrate. In one embodiment, the porous substrate is retained within the cavity of the delivery vehicle such that the increase in pressure drop across the delivery vehicle is less than 10 mm _H2O compared to a delivery vehicle without the porous substrate. In one embodiment, the porous substrate is retained within the cavity of the delivery vehicle such that the increase in pressure drop across the delivery vehicle compared to a delivery vehicle without the porous substrate is less than 7.5 mm _H2O . There is. In one aspect, the porous substrate is retained within the cavity of the delivery vehicle such that the increase in pressure drop across the delivery vehicle is less than 5 mm _H2O compared to a delivery vehicle without the porous substrate.
In this regard, the porous substrate can be retained within the cavity of the housing in a variety of configurations to minimize increased pressure drop. For example, the porous substrate can be in the form of pellets.

It will be appreciated that in the above embodiments, the delivery vehicle may be supplied with a porous substrate that does not contain a formulation that specifically impregnates the porous substrate. Such a configuration may allow users to functionalize the porous substrate themselves.

Further aspects

Delivery vehicles of the invention may include a housing or container. In one aspect, the housing is configured to be removably attached to the aerosol delivery device, specifically at a point along the airflow path of the aerosol delivery device. The present invention further provides a containerized delivery vehicle for functionalizing an aerosol, comprising: (a) a housing/container; and (b) a delivery vehicle for functionalizing an aerosol proximate the delivery vehicle. a porous substrate material comprising at least one porous thermoplastic polymer and at least one formulation retained within the thermoplastic polymer, the formulation comprising at least one functionalized component; Further provided is a packaged delivery vehicle comprising a delivery vehicle wherein the amount of formulation retained within the porous thermoplastic polymer is at least 30% w/w.

As discussed herein, in one embodiment, the delivery vehicle may contain any of the carriers described above as an aerosol-forming material. In further embodiments, an aerosol-forming material that is different from the delivery vehicle may be provided. Accordingly, in a further aspect, the present invention provides a delivery vehicle for functionalizing an aerosol proximate to the delivery vehicle, comprising: (a) an aerosol-forming material; and (b) at least one porous thermoplastic polymer. , at least one formulation retained within the thermoplastic polymer, the formulation comprising at least one functionalized component retained within the porous thermoplastic polymer. The invention further provides an aerosolizable product comprising a delivery vehicle, wherein the amount of formulation is at least 30% w/w. In this regard, the term "aerosolizable product" refers to a combination of one or more materials, at least one of which is capable of forming a condensed aerosol after heating to a suitable temperature. Therefore, not all components of the aerosolizable products of the present invention need be "aerosolized."

The present invention is a method for forming a functionalized aerosol comprising:
(a) a porous delivery vehicle for functionalizing an aerosol proximate the delivery vehicle, the delivery vehicle comprising at least one porous thermoplastic polymer and at least one compound retained within the thermoplastic polymer; wherein the formulation includes at least one functionalized component and the amount of the formulation retained within the porous thermoplastic polymer is at least 30% w/w. and (b) positioning the aerosol in close proximity to the delivery vehicle.

The methods of the invention may include additional steps either before the recited steps, after the recited steps, or between one or more of the recited steps.

The present invention
(a) an aerosol delivery/generation device; and (b) a delivery vehicle for functionalizing an aerosol proximate the delivery vehicle, the delivery vehicle comprising at least one porous thermoplastic polymer and retained within the thermoplastic polymer. at least one blend, the blend includes at least one functionalized component, and the amount of blend retained within the porous thermoplastic polymer is at least 30%. Further provided is an electronic aerosol delivery system comprising a delivery vehicle that is w/w.

In one aspect, the aerosol delivery/generation device has an airflow path through which the aerosol produced by the device flows. In one embodiment, the delivery vehicle is located within the airflow path. In one embodiment, the delivery vehicle is positioned within the airflow path such that the aerosol passes through the porous substrate.

The invention will be explained in more detail, by way of example only, with reference to the accompanying drawings, in which: FIG.

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The invention will now be described with reference to the following non-limiting examples.

In this example, Accurel® MP/XP material, which is a porous polymer, was utilized. The MP and XP product lines are manufactured with different cell formers and have slightly different properties such as porosity levels, additive fill times and fill levels. Products can be manufactured using PP, PE, EVA, PS, PET, PA6 PA12, PC, PLA, SAN and PMNA. A PVOH version is also available. Accurel®'s porous structure is capable of absorbing large amounts of liquid or low melting point additives. Upon mixing, the additives penetrate the cell structure by capillary action, resulting in a free-flowing, dry superconcentrate.

Fragrance/fragrance filling amount

In this study, ACCUREL microporous polymer MP100-PP-polypropylene was used.

Sample 1 - 10g of Accurel MP100-PP (10g) was placed in a glass bottle and 23.1g of cherry fragrance or menthol was added. The glass bottle was capped with an aluminum lid with a spindle attached. The spindle was attached to the chuck of a rotating stirrer set horizontally. The bottle and contents were gently rotated (Caframo top stirrer, model BDC50) at 44 rpm for 2 hours at room temperature until all the liquid entered the porous particles and the final product was 70% fragrance/perfume by weight. A dry, free-flowing product was obtained.

Sample 2 - Repeated the preparation method of Sample 1, replacing the menthol with 50% peppermint oil/50% menthol.

test

Aliquots (5 g) of loaded particles were then incubated (3 times) at the relevant temperature and then weighed at regular intervals during the first 24 hours. Weight loss was calculated and plotted against time. For comparison, control perfume particles were incubated in parallel with the menthol/cherry filled particles. Control samples at 20°C, 40°C, 60°C, 80°C and 100°C are shown in Figure 1. Sample 1 at 20°C, 40°C, 60°C, 80°C and 100°C is shown in Figure 2. Sample 2 at 20°C, 40°C, 60°C, 80°C and 100°C is shown in Figure 2.

Within 24 hours, weight loss from Accurel was approaching 70% for both cherry fragrance and peppermint/menthol. The peak recorded at 100°C around 15-20 hours is related to the plotting program and not the actual result.

The achieved loading was found to be very high. At high temperatures, this porous material does not retain inclusions particularly well. However, at moderate temperatures, such as those at which products are normally stored, losses over time were small.

The thermoplastic polymer used in this example was identified as a very good material for producing highly concentrated free-flowing substrates containing liquid perfume.

pressure drop investigation

The following experiment was conducted to test the effect of the delivery vehicle on the pressure drop across the aerosol delivery device.

An aerosol delivery device available from British American Tabacco (eTank Pro, www.govype.com) was used to evaluate the effect of a delivery vehicle containing a functionalized porous substrate on pressure drop across a typical device. The eTank Pro device has a removable drip tip (mouthpiece) so it can be replaced with the delivery vehicle of the invention.

The delivery vehicle used in this example was Accurel MP100-PP (approximately 2.75 mm x 2.89 mm x 1.69 mm semi-cylindrical prism pellets, 34.40 mg per pellet based on a mass of 32 pellets). pellets with average mass). 15-20 pellets were loaded into a delivery vehicle mouthpiece sized similar to the eTankPro mouthpiece. The cylindrical cavity of the mouthpiece in which the pellet was held had a total volume of 655 ^mm3 . For comparison purposes, the same delivery vehicle mouthpiece without the porous substrate and with cellulose acetate in place of the porous substrate was used.

As can be seen from Table 1, delivery vehicles comprising a porous substrate comprising at least one porous thermoplastic polymer wherein the amount of formulation retained within the porous thermoplastic polymer is at least 30% w/w. When used, the effect on the pressure drop across the device is much less than when using the same delivery vehicle mouthpiece containing cellulose acetate. This is an advantage because when using a delivery vehicle according to the present invention, the user will not notice a significant change (if any) in the pressure drop across the device. On the other hand, due to the porous nature of thermoplastic polymers, it is possible to fill the porous substrate with a relatively large amount of formulation, thereby resulting in proper functionalization of the aerosol as it passes through the delivery vehicle. It is possible.

Various modifications and variations of this invention will be apparent to those skilled in the art without departing from the scope and spirit of this invention. Although the invention has been described with respect to certain preferred embodiments, it should be understood that the claimed invention should not be unduly limited to such specific embodiments. Indeed, various modifications of the described modes for carrying out the invention that are obvious to those skilled in chemistry or related fields are intended to be within the scope of the following claims.

Claims (25)

A delivery vehicle for functionalizing an aerosol as the aerosol flows proximate the delivery vehicle, the formulation of at least one formulation such that the at least one formulation is retained within the pores of the thermoplastic polymer. the formulation includes at least one functionalized component retained within the porous thermoplastic polymer; The amount of said formulation applied is at least 30% w/w based on said porous substrate, and said at least one thermoplastic polymer is acrylonitrile butadiene styrene, natural rubber, nylon 6, polyamide, polyamide. Imide, polyarylate, polycarbonate, polydimethylsiloxane, polyetheretherketone, polyetherimide, polyethersulfone, polyethylene terephthalate, polymethyl methacrylate, polyoxymethylene, polyphenylene sulfide, polypropylene, polystyrene, polysulfone, polytetrafluoroethylene, poly A delivery vehicle selected from vinyl chloride, and mixtures thereof . The delivery vehicle of claim 1, wherein the porous substrate is contained in a housing. 3. The delivery vehicle of claim 2, wherein the housing is configured to be removably attached to an aerosol delivery device. 4. The delivery vehicle of claim 3, wherein the housing is configured to be removably attached to an outlet of an aerosol delivery device. A delivery vehicle according to any one of claims 1 to 4, wherein the at least one functionalized ingredient is at least one perfume ingredient. The at least one fragrance ingredient is (4-(para-)methoxyphenyl)-2-butanone, vanillin, γ-undecalactone, menthone, 5-propenylguaetol, menthol, para-mentha-8-thiol. 6. The delivery vehicle of claim 5, selected from the group consisting of -3-one, and mixtures thereof. 7. The delivery vehicle of claim 6, wherein the at least one perfume ingredient is at least menthol. The at least one functionalized component contains at least 50 wt.% based on the formulation. A delivery vehicle according to any one of claims 1 to 7, wherein the delivery vehicle is present in a total amount of %. The at least one functionalized component contains at least 70 wt.% based on the formulation. A delivery vehicle according to any one of claims 1 to 7, wherein the delivery vehicle is present in a total amount of %. Delivery vehicle according to any one of claims 1 to 9, wherein the amount of the formulation retained within the porous thermoplastic polymer is at least 50% w/w based on the porous substrate. . Delivery vehicle according to any one of claims 1 to 9, wherein the amount of the formulation retained within the porous thermoplastic polymer is at least 70% w/w based on the porous substrate. . A delivery vehicle according to any preceding claim, wherein the at least one thermoplastic polymer is at least polypropylene. 13. According to any one of claims 1 to 12 , the delivery vehicle comprises a first thermoplastic polymer and a second thermoplastic polymer, the first thermoplastic polymer and the second thermoplastic polymer being different from each other. Delivery vehicle as described. Delivery vehicle according to any one of claims 1 to 13 , wherein the functionalized component is solid at a temperature of 40°C. Delivery vehicle according to any one of claims 1 to 14 , wherein the functionalized component is solid at a temperature of 60°C. A delivery vehicle according to any one of claims 1 to 15 , wherein the functionalized component is a powder. 17. The delivery vehicle of claim 16 , wherein the powder is a free flowing powder. A delivery vehicle according to any one of claims 1 to 15 , wherein the delivery vehicle further comprises a carrier. The carrier is
(i) selected from water, glycerol, propylene glycol, and mixtures thereof;
19. The delivery vehicle of claim 18 , wherein the delivery vehicle is (ii) selected from glycerol, propylene glycol, or a mixture thereof, or (iii) is a mixture of glycerol and propylene glycol. A delivery vehicle according to any one of claims 1 to 19 , wherein the delivery vehicle further comprises an active agent. 21. The delivery vehicle of claim 20 , wherein the active agent is at least nicotine. Delivery vehicle according to any one of the preceding claims, wherein the particles of the at least one porous thermoplastic polymer are in the form of a powder, pellet or granule. 23. The delivery vehicle of claim 22, wherein the particles of the at least one porous thermoplastic polymer are in a dry, free-flowing state. A method for forming a functionalized aerosol, the method comprising:
A method comprising: (a) providing a delivery vehicle according to any one of claims 1 to 23 ; and (b) placing an aerosol in close proximity to said delivery vehicle. An electronic aerosol delivery system comprising: (a) an aerosol generating device; and (b) a delivery vehicle according to any one of claims 1 to 23 .

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