EP3769757A3 - Bildgebung von histondeacetylasen mit einem radiotracer mittels positronenemissionstomografie - Google Patents
Bildgebung von histondeacetylasen mit einem radiotracer mittels positronenemissionstomografie Download PDFInfo
- Publication number
- EP3769757A3 EP3769757A3 EP20190478.6A EP20190478A EP3769757A3 EP 3769757 A3 EP3769757 A3 EP 3769757A3 EP 20190478 A EP20190478 A EP 20190478A EP 3769757 A3 EP3769757 A3 EP 3769757A3
- Authority
- EP
- European Patent Office
- Prior art keywords
- radiotracer
- positron emission
- emission tomography
- histone deacetylases
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/08—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nuclear Medicine (AREA)
- Furan Compounds (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361892966P | 2013-10-18 | 2013-10-18 | |
PCT/US2014/061179 WO2015058106A1 (en) | 2013-10-18 | 2014-10-17 | Imaging histone deacetylases with a radiotracer using positron emission tomography |
EP14853451.4A EP3062783B1 (de) | 2013-10-18 | 2014-10-17 | Bildgebung von histondeacetylasen mit einem radiotracer mittels positronenemissionstomografie |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP14853451.4A Division EP3062783B1 (de) | 2013-10-18 | 2014-10-17 | Bildgebung von histondeacetylasen mit einem radiotracer mittels positronenemissionstomografie |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3769757A2 EP3769757A2 (de) | 2021-01-27 |
EP3769757A3 true EP3769757A3 (de) | 2021-10-06 |
Family
ID=52828752
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP20190478.6A Pending EP3769757A3 (de) | 2013-10-18 | 2014-10-17 | Bildgebung von histondeacetylasen mit einem radiotracer mittels positronenemissionstomografie |
EP14853451.4A Active EP3062783B1 (de) | 2013-10-18 | 2014-10-17 | Bildgebung von histondeacetylasen mit einem radiotracer mittels positronenemissionstomografie |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP14853451.4A Active EP3062783B1 (de) | 2013-10-18 | 2014-10-17 | Bildgebung von histondeacetylasen mit einem radiotracer mittels positronenemissionstomografie |
Country Status (4)
Country | Link |
---|---|
US (3) | US10188756B2 (de) |
EP (2) | EP3769757A3 (de) |
AU (1) | AU2014337102B2 (de) |
WO (1) | WO2015058106A1 (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106810508B (zh) * | 2017-01-05 | 2019-12-10 | 浙江农林大学暨阳学院 | 一种铁催化多组分反应合成苯并[1,4]-氧氮杂卓化合物的方法 |
US10357493B2 (en) | 2017-03-10 | 2019-07-23 | Selenity Therapeutics (Bermuda), Ltd. | Metalloenzyme inhibitor compounds |
CN110770206B (zh) * | 2017-04-11 | 2022-11-25 | 通用医疗公司 | Hdac6抑制剂 |
TWI650139B (zh) * | 2017-10-11 | 2019-02-11 | 行政院原子能委員會核能硏究所 | 含有放射性同位素氟的異羥肟酸類造影劑、其製備方法及其用途 |
US11481934B2 (en) * | 2018-10-10 | 2022-10-25 | New York University | System, method, and computer-accessible medium for generating magnetic resonance imaging-based anatomically guided positron emission tomography reconstruction images with a convolutional neural network |
Citations (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002026696A1 (en) * | 2000-09-29 | 2002-04-04 | Prolifix Limited | Carbamic acid compounds comprising an amide linkage as hdac inhibitors |
WO2002026703A1 (en) * | 2000-09-29 | 2002-04-04 | Prolifix Limited | Carbamic acid compounds comprising an ether linkage as hdac inhibitors |
WO2002046144A1 (en) * | 2000-12-07 | 2002-06-13 | F. Hoffmann-La Roche Ag | Tetralone derivatives as antitumor agents |
WO2002062773A1 (en) * | 2001-01-27 | 2002-08-15 | F. Hoffmann-La Roche Ag | Tricyclic lactam and sultam derivatives and their use as histone deacetylase inhibitors |
WO2003024448A2 (en) * | 2001-09-14 | 2003-03-27 | Methylgene, Inc. | Inhibitors of histone deacetylase |
WO2003070691A1 (fr) * | 2002-02-21 | 2003-08-28 | Osaka Industrial Promotion Organization | Derive de n-hydroxycarboxamide |
WO2003076422A1 (en) * | 2002-03-13 | 2003-09-18 | Janssen Pharmaceutica N.V. | Sulfonyl-derivatives as novel inhibitors of histone deacetylase |
WO2003082288A1 (en) * | 2002-04-03 | 2003-10-09 | Topotarget Uk Limited | Carbamic acid compounds comprising a piperazine linkage as hdac inhibitors |
WO2003087066A1 (en) * | 2002-04-11 | 2003-10-23 | Sk Chemicals, Co., Ltd. | α,β-UNSATURATED HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS |
WO2004013130A1 (en) * | 2002-08-02 | 2004-02-12 | Argenta Discovery Limited | Substituted thienyl-hydroxamic acids as histone deacetylase inhibitors |
EP1401824A2 (de) * | 2001-06-15 | 2004-03-31 | F. Hoffman-la Roche AG | Aromatische hydroxamsäurederivate, die sich als hdac inhibitoren eignen |
WO2004035525A1 (en) * | 2002-10-17 | 2004-04-29 | Methylgene Inc. | Inhibitors of histone deacetylase |
CN1513839A (zh) * | 2003-07-04 | 2004-07-21 | 深圳微芯生物科技有限责任公司 | 具有分化和抗增殖活性的苯甲酰胺类组蛋白去乙酰化酶抑制剂及其药用制剂 |
WO2004069823A1 (en) * | 2003-02-04 | 2004-08-19 | Methylgene, Inc. | Inhibitors of histone deacetylase |
WO2004069803A2 (en) * | 2003-02-06 | 2004-08-19 | F. Hoffmann-La Roche Ag | Mono-acylated o-phenylendiamines derivatives and their use against cancer |
WO2004072047A1 (en) * | 2003-02-11 | 2004-08-26 | Fujisawa Pharmaceutical Co., Ltd. | Indoles, benzimidazoles or naphhimidazoles as histone deacetylase (hdac) inhibitors |
WO2004092115A2 (en) * | 2003-04-07 | 2004-10-28 | Axys Pharmaceuticals Inc. | Hydroxamates as therapeutic agents |
EP1485378A1 (de) * | 2002-03-13 | 2004-12-15 | Janssen Pharmaceutica N.V. | Piperazinyl-, piperidinyl- und morpholinylderivate als neue inhibitoren von histon-deacetylase |
WO2005030705A1 (en) * | 2003-09-24 | 2005-04-07 | Methylgene, Inc. | Inhibitors of histone deacetylase |
WO2005040101A1 (en) * | 2003-10-27 | 2005-05-06 | S*Bio Pte Ltd | Acylurea connected and sulfonylurea connected hydroxamates |
WO2005075469A1 (en) * | 2004-02-04 | 2005-08-18 | Argenta Discovery Limited | Thiazolyl-hydroxamic acids and thiadiazolyl-hydroxamic acids, and use thereof for treating diseases associated with histone deacetylase enzymatic activity |
WO2005086898A2 (en) * | 2004-03-08 | 2005-09-22 | Miikana Therapeutics, Inc. | Inhibitors of histone deacetylase |
WO2005087724A2 (en) * | 2004-03-11 | 2005-09-22 | Altana Pharma Ag | Sulphonylpyrroles as hdac inhibitors |
WO2005092899A1 (en) * | 2004-03-26 | 2005-10-06 | Methylgene Inc. | Inhibitors of histone deacetylase |
WO2005121073A1 (en) * | 2004-06-10 | 2005-12-22 | Cancer Research Technology Limited | Inhibitors of histone deacetylase |
WO2006010750A1 (en) * | 2004-07-28 | 2006-02-02 | Janssen Pharmaceutica N.V. | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase |
WO2006101455A1 (en) * | 2005-03-21 | 2006-09-28 | S*Bio Pte Ltd | Imidazo[1,2-a]pyridine derivatives: preparation and pharmaceutical applications |
US7154002B1 (en) * | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
WO2007017728A2 (en) * | 2005-08-05 | 2007-02-15 | Orchid Research Laboratories Limited | Novel heterocyclic compounds |
WO2007054776A2 (en) * | 2005-11-10 | 2007-05-18 | Orchid Research Laboratories Limited | Stilbene like compounds as novel hdac inhibitors |
WO2008036046A1 (en) * | 2006-09-20 | 2008-03-27 | S*Bio Pte Ltd | IMIDAZO[l,2-a]PYRIDINE HYDROXYMATE COMPOUNDS THAT ARE INHIBITORS OF HISTONE DEACETYLASE |
WO2008075757A1 (en) * | 2006-12-15 | 2008-06-26 | Astellas Pharma Inc. | N-hydroxyacrylamide compounds |
WO2010043953A2 (en) * | 2008-10-15 | 2010-04-22 | Orchid Research Laboratories Ltd. | Novel bridged cyclic compounds as histone deacetylase inhibitors |
WO2011019393A2 (en) * | 2009-08-11 | 2011-02-17 | President And Fellows Of Harvard College | Class- and isoform-specific hdac inhibitors and uses thereof |
WO2011058582A1 (en) * | 2009-11-16 | 2011-05-19 | Orchid Research Laboratories Ltd. | Histone deacetylase inhibitors for the treatment of fungal infections |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT103200B (pt) | 2004-09-30 | 2006-08-24 | Taguspark-Soc. Prom.Desenv.Parq.Ci.Tec.Area Lisboa | Sistema de tomografia por emissão de positrões (pet) |
WO2009047615A2 (en) | 2007-10-10 | 2009-04-16 | Orchid Research Laboratories Limited | Novel histone deacetylase inhibitors |
CN101970399A (zh) * | 2007-12-14 | 2011-02-09 | 乔治敦大学 | 组蛋白脱乙酰酶抑制剂 |
US20120077774A1 (en) | 2009-05-28 | 2012-03-29 | Cornell University | Compositions and their use for removing cholesterol |
US20110312956A1 (en) | 2010-06-16 | 2011-12-22 | Paul Jackson | ARYLINDENOPYRIMIDINES WITH REDUCED hERG CHANNEL BINDING |
US9540395B2 (en) * | 2011-02-28 | 2017-01-10 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
-
2014
- 2014-10-17 EP EP20190478.6A patent/EP3769757A3/de active Pending
- 2014-10-17 US US15/030,214 patent/US10188756B2/en active Active
- 2014-10-17 WO PCT/US2014/061179 patent/WO2015058106A1/en active Application Filing
- 2014-10-17 AU AU2014337102A patent/AU2014337102B2/en active Active
- 2014-10-17 EP EP14853451.4A patent/EP3062783B1/de active Active
-
2018
- 2018-12-07 US US16/213,358 patent/US10842891B2/en active Active
-
2020
- 2020-10-09 US US17/066,925 patent/US20210030899A1/en active Pending
Patent Citations (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002026703A1 (en) * | 2000-09-29 | 2002-04-04 | Prolifix Limited | Carbamic acid compounds comprising an ether linkage as hdac inhibitors |
WO2002026696A1 (en) * | 2000-09-29 | 2002-04-04 | Prolifix Limited | Carbamic acid compounds comprising an amide linkage as hdac inhibitors |
WO2002046144A1 (en) * | 2000-12-07 | 2002-06-13 | F. Hoffmann-La Roche Ag | Tetralone derivatives as antitumor agents |
WO2002062773A1 (en) * | 2001-01-27 | 2002-08-15 | F. Hoffmann-La Roche Ag | Tricyclic lactam and sultam derivatives and their use as histone deacetylase inhibitors |
EP1401824A2 (de) * | 2001-06-15 | 2004-03-31 | F. Hoffman-la Roche AG | Aromatische hydroxamsäurederivate, die sich als hdac inhibitoren eignen |
WO2003024448A2 (en) * | 2001-09-14 | 2003-03-27 | Methylgene, Inc. | Inhibitors of histone deacetylase |
WO2003070691A1 (fr) * | 2002-02-21 | 2003-08-28 | Osaka Industrial Promotion Organization | Derive de n-hydroxycarboxamide |
WO2003076422A1 (en) * | 2002-03-13 | 2003-09-18 | Janssen Pharmaceutica N.V. | Sulfonyl-derivatives as novel inhibitors of histone deacetylase |
EP1485378A1 (de) * | 2002-03-13 | 2004-12-15 | Janssen Pharmaceutica N.V. | Piperazinyl-, piperidinyl- und morpholinylderivate als neue inhibitoren von histon-deacetylase |
WO2003082288A1 (en) * | 2002-04-03 | 2003-10-09 | Topotarget Uk Limited | Carbamic acid compounds comprising a piperazine linkage as hdac inhibitors |
WO2003087066A1 (en) * | 2002-04-11 | 2003-10-23 | Sk Chemicals, Co., Ltd. | α,β-UNSATURATED HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS |
WO2004013130A1 (en) * | 2002-08-02 | 2004-02-12 | Argenta Discovery Limited | Substituted thienyl-hydroxamic acids as histone deacetylase inhibitors |
US7154002B1 (en) * | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
WO2004035525A1 (en) * | 2002-10-17 | 2004-04-29 | Methylgene Inc. | Inhibitors of histone deacetylase |
WO2004069823A1 (en) * | 2003-02-04 | 2004-08-19 | Methylgene, Inc. | Inhibitors of histone deacetylase |
WO2004069803A2 (en) * | 2003-02-06 | 2004-08-19 | F. Hoffmann-La Roche Ag | Mono-acylated o-phenylendiamines derivatives and their use against cancer |
WO2004072047A1 (en) * | 2003-02-11 | 2004-08-26 | Fujisawa Pharmaceutical Co., Ltd. | Indoles, benzimidazoles or naphhimidazoles as histone deacetylase (hdac) inhibitors |
WO2004092115A2 (en) * | 2003-04-07 | 2004-10-28 | Axys Pharmaceuticals Inc. | Hydroxamates as therapeutic agents |
CN1513839A (zh) * | 2003-07-04 | 2004-07-21 | 深圳微芯生物科技有限责任公司 | 具有分化和抗增殖活性的苯甲酰胺类组蛋白去乙酰化酶抑制剂及其药用制剂 |
WO2005030705A1 (en) * | 2003-09-24 | 2005-04-07 | Methylgene, Inc. | Inhibitors of histone deacetylase |
WO2005040101A1 (en) * | 2003-10-27 | 2005-05-06 | S*Bio Pte Ltd | Acylurea connected and sulfonylurea connected hydroxamates |
WO2005075469A1 (en) * | 2004-02-04 | 2005-08-18 | Argenta Discovery Limited | Thiazolyl-hydroxamic acids and thiadiazolyl-hydroxamic acids, and use thereof for treating diseases associated with histone deacetylase enzymatic activity |
WO2005086898A2 (en) * | 2004-03-08 | 2005-09-22 | Miikana Therapeutics, Inc. | Inhibitors of histone deacetylase |
WO2005087724A2 (en) * | 2004-03-11 | 2005-09-22 | Altana Pharma Ag | Sulphonylpyrroles as hdac inhibitors |
WO2005092899A1 (en) * | 2004-03-26 | 2005-10-06 | Methylgene Inc. | Inhibitors of histone deacetylase |
WO2005121073A1 (en) * | 2004-06-10 | 2005-12-22 | Cancer Research Technology Limited | Inhibitors of histone deacetylase |
WO2006010750A1 (en) * | 2004-07-28 | 2006-02-02 | Janssen Pharmaceutica N.V. | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase |
WO2006101455A1 (en) * | 2005-03-21 | 2006-09-28 | S*Bio Pte Ltd | Imidazo[1,2-a]pyridine derivatives: preparation and pharmaceutical applications |
WO2007017728A2 (en) * | 2005-08-05 | 2007-02-15 | Orchid Research Laboratories Limited | Novel heterocyclic compounds |
WO2007054776A2 (en) * | 2005-11-10 | 2007-05-18 | Orchid Research Laboratories Limited | Stilbene like compounds as novel hdac inhibitors |
WO2008036046A1 (en) * | 2006-09-20 | 2008-03-27 | S*Bio Pte Ltd | IMIDAZO[l,2-a]PYRIDINE HYDROXYMATE COMPOUNDS THAT ARE INHIBITORS OF HISTONE DEACETYLASE |
WO2008075757A1 (en) * | 2006-12-15 | 2008-06-26 | Astellas Pharma Inc. | N-hydroxyacrylamide compounds |
WO2010043953A2 (en) * | 2008-10-15 | 2010-04-22 | Orchid Research Laboratories Ltd. | Novel bridged cyclic compounds as histone deacetylase inhibitors |
WO2011019393A2 (en) * | 2009-08-11 | 2011-02-17 | President And Fellows Of Harvard College | Class- and isoform-specific hdac inhibitors and uses thereof |
WO2011058582A1 (en) * | 2009-11-16 | 2011-05-19 | Orchid Research Laboratories Ltd. | Histone deacetylase inhibitors for the treatment of fungal infections |
Non-Patent Citations (2)
Title |
---|
GOPALAN BALASUBRAMANIAN ET AL: "Discovery of adamantane based highly potent HDAC inhibitors", BIORGANIC & MEDICINAL CHEMISTRY LETTERS,, vol. 23, no. 9, 14 March 2013 (2013-03-14), pages 2532 - 2537, XP028546972, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2013.03.002 * |
M KALISZCZAK ET AL: "A novel small molecule hydroxamate preferentially inhibits HDAC6 activity and tumour growth", BRITISH JOURNAL OF CANCER, vol. 108, no. 2, 5 February 2013 (2013-02-05), GB, pages 342 - 350, XP055385986, ISSN: 0007-0920, DOI: 10.1038/bjc.2012.576 * |
Also Published As
Publication number | Publication date |
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EP3769757A2 (de) | 2021-01-27 |
US20190240357A1 (en) | 2019-08-08 |
US20160271276A1 (en) | 2016-09-22 |
US10188756B2 (en) | 2019-01-29 |
US10842891B2 (en) | 2020-11-24 |
AU2014337102B2 (en) | 2019-02-28 |
WO2015058106A1 (en) | 2015-04-23 |
EP3062783B1 (de) | 2020-08-12 |
US20210030899A1 (en) | 2021-02-04 |
EP3062783A1 (de) | 2016-09-07 |
AU2014337102A1 (en) | 2016-06-02 |
EP3062783A4 (de) | 2017-08-02 |
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