EP3768351A1 - Dispositif de dégazage pour du sang et système pour le traitement de sang - Google Patents

Dispositif de dégazage pour du sang et système pour le traitement de sang

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Publication number
EP3768351A1
EP3768351A1 EP19712974.5A EP19712974A EP3768351A1 EP 3768351 A1 EP3768351 A1 EP 3768351A1 EP 19712974 A EP19712974 A EP 19712974A EP 3768351 A1 EP3768351 A1 EP 3768351A1
Authority
EP
European Patent Office
Prior art keywords
blood
chamber
degassing device
vacuum
sub
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19712974.5A
Other languages
German (de)
English (en)
Inventor
Ahmed Ali Kashefi-Khorasani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rheinisch Westlische Technische Hochschuke RWTH
Original Assignee
Rheinisch Westlische Technische Hochschuke RWTH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rheinisch Westlische Technische Hochschuke RWTH filed Critical Rheinisch Westlische Technische Hochschuke RWTH
Publication of EP3768351A1 publication Critical patent/EP3768351A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1698—Blood oxygenators with or without heat-exchangers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/32—Oxygenators without membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/75—General characteristics of the apparatus with filters
    • A61M2205/7536—General characteristics of the apparatus with filters allowing gas passage, but preventing liquid passage, e.g. liquophobic, hydrophobic, water-repellent membranes

Definitions

  • the invention relates to a degassing device for the degassing of blood, in particular for the removal of dissolved gas or gas bubbles from blood.
  • the invention also relates to a system for the extracorporeal treatment of blood comprising a blood collection unit, in particular a blood collection cannula and a blood return unit, in particular blood return cannula, wherein at least one blood-carrying tube, at least one blood pump and an oxygenator is arranged between the units, in particular so that with the at least one Blood pump blood is pumpable through the oxygenator.
  • the invention likewise relates to a system and a method for the extracorporeal preparation of blood which has been taken from a human or animal body, in which gas present in the blood, preferably gas bubbles, is / are eliminated.
  • dissolved gas in the blood is removed from the blood.
  • Dissolved gas is e.g. such gas, which is connected to the
  • Hemoglobin is bound, e.g. Carbon dioxide or carbon monoxide.
  • Such dissolved gases are thus not present in the form of bubbles in the blood.
  • these two types of gas are undesirable in the blood because they limit the oxygenation of a living being.
  • oxygenators are used for the carbon dioxide elimination. These are essentially devices with a chamber in which a bundle of semipermeable hollow fibers is arranged, through which oxygen passes for oxygenation, while the blood flows around the hollow fibers. Due to the high oxygen partial pressure and thus low
  • Carbon dioxide partial pressure in the hollow fibers is displaced by the semipermeable hollow fibers through the carbon dioxide from the blood around the hollow fibers around by means of oxygen, thus thus generating a gas exchange.
  • Elimination of carbon monoxide from blood occurs e.g. in that an affected patient is subjected to a so-called hyperbaric oxygen therapy in a hyperbaric chamber or at least by the patient
  • withdrawn blood is treated with oxygen overpressure and then returned to the patient.
  • a disadvantage of such methods is that the gas exchange and thus the degassing of the unwanted gas from the blood takes place only via the effect of the increased partial pressure of oxygen, which thus requires that a
  • Oxygen supply must be provided to eliminate a certain amount of dissolved gas from the blood.
  • a further disadvantage is that the oxygen components not participating in the gas exchange are usually lost to the environment.
  • the diffusion processes are slow. Elimination of e.g. Carbon monoxide from blood, however, is time-critical and must be done as quickly as possible.
  • degassing also means that gases not dissolved in the blood, e.g. Bubble-shaped gases in the blood are removed from the blood.
  • gases e.g. Ambient air can become
  • Defoamer devices made essentially comprising a filter / sponge through which the blood flows through and thereby the
  • the object of the invention is thus to provide a degassing device for degassing blood, a system of the type mentioned and a method for degassing of blood, each with a higher effectiveness is achieved, in particular a faster treatment option and / or achieved more gentle and / or safer treatment option becomes.
  • a degassing device of the invention should be designed to save oxygen, in particular if it is used simultaneously for the oxygenation of blood.
  • a blood chamber having a blood inlet and a blood outlet through which blood can be passed through the blood chamber and having at least one negative pressure chamber having a negative pressure port through which the at least one negative pressure chamber is provided with a negative pressure and at least one semipermeable membrane interposed between the at least one
  • Vacuum chamber and the blood chamber is arranged. Accordingly, the volumes of blood chamber and vacuum chamber are separated by means of at least one semipermeable membrane.
  • the object is also achieved by a method of the type mentioned, in which the dissolved gas thereby eliminating or eliminating gas bubbles by passing the blood along one side of a semipermeable membrane, with the other side of the semipermeable membrane being subjected to a depression.
  • a negative pressure is understood as meaning a pressure which is at least lower than the atmospheric ambient pressure in that environment in which the degassing device or the system is located or the method is carried out.
  • the degassing device or the system is located or the method is carried out.
  • Negative pressure in the vacuum chamber by at least 100 mbar, more preferably by at least 200 mbar, even more preferably by at least 300 mbar, even more preferably by at least 400 mbar smaller, even more preferably by at least 600 mbar smaller and even more preferably at least 800 mbar smaller than the atmospheric ambient pressure.
  • any negative pressure which is less than the ambient pressure, a reduction of the gas bubbles, preferably causes a complete elimination, since in the gas bubbles is always the ambient pressure.
  • the negative pressure in the vacuum chamber is preferably selected so that the partial pressure of the gas to be eliminated from the blood in the vacuum chamber is smaller than the partial pressure of this gas in the blood.
  • the invention may be e.g. Provide that in the
  • Vacuum chamber is an oxygen atmosphere, e.g. as a result of that
  • Such a procedure is particularly rapid in the elimination of the undesired, e.g. dissolved gas or gas bubbles from blood.
  • this procedure is gentler on the blood, since, in contrast to the prior art, the blood does not have to traverse a filter / sponge, but here the gas passes through the at least one membrane. There are thus no shear forces on the blood.
  • the invention may provide that before a return of the so
  • the blood is subjected to a further oxygenation, for example by means of a conventional oxygenator.
  • a conventional oxygenator for example, such an oxygenator with a degassing device according to the invention can be fluidly connected in series, so in particular after the degassing follow.
  • the named negative pressure is provided by means of a negative pressure source connected to the negative pressure port of the negative pressure chamber.
  • a vacuum source may be formed by a vacuum pump, such as a diaphragm pump or rotary vane pump.
  • the term vacuum pump hereby does not imply the ability to create an ideal vacuum, but only to be able to produce a suppression of the environment.
  • the invention can provide that each vacuum chamber of the device to a separate
  • Vacuum source e.g. a vacuum pump is connected, or also that a plurality of vacuum chambers of all or all vacuum chambers are connected to a common vacuum source.
  • a semipermeable membrane is preferably understood to mean a membrane which is suitable for gas, e.g. Carbon dioxide and / or carbon monoxide and / or oxygen permeable and for blood, or its components (for example
  • Such a semipermeable membrane may e.g. a silicone membrane or e.g. be formed of the material polypropylene or generally of a hydrophobic polymer material.
  • a membrane may have pores through which gas transport may be convective.
  • such a semipermeable membrane has a pore size smaller than 200 nanometers.
  • a semipermeable membrane may also be formed without pores, the gas transport then being effected by diffusion through the membrane.
  • the blood chamber comprises a first and a second sub-chamber, which in a direction perpendicular to
  • Direction of gravity are arranged side by side, and one Bypass has bridging region which connects the two sub-chambers at their upper ends, wherein the blood inlet is arranged in the lower region of the first sub-chamber and the blood outlet is arranged in the lower region of the second sub-chamber.
  • Such an embodiment essentially leads to a U-shaped flow of the blood flowing through the blood chamber, namely in the first sub-chamber against the direction of gravity up, then in the bridging region between the sub-chambers, in particular at least substantially in the horizontal direction and then in the second sub-chamber with the
  • the blood chamber adjoins at least one vacuum chamber via the at least one semipermeable membrane, the blood is degassed on its way through the blood chamber, in particular gas bubbles are eliminated.
  • the flow in the second sub-chamber in the direction of gravity causes the remaining gas bubbles to rise in opposite directions due to their buoyancy and not leave the device and through further depression of pressure across the membrane be reduced.
  • the device is set up so that the blood in the first sub-chamber flows at least in the middle parallel to the direction of gravity and in the second sub-chamber at least in the middle parallel in the direction of gravity.
  • a preferred development can provide that at least a portion of the upper wall region of the bridging region by a
  • Semipermeable membrane is formed, in particular a semipermeable flat membrane, one side of which faces the volume of the blood chamber and the other side of the volume of the vacuum chamber, in particular a faces of several vacuum chambers. This semipermeable
  • Membrane may be the only semipermeable membrane of the degassing device or one of several.
  • further semipermeable membranes may be arranged in at least one or both subchambers.
  • the membrane in the bridging region in the degassing device may form or at least comprise the highest point at which the blood flows past on its way through the blood chamber.
  • a further preferred embodiment provide that in the blood inlet of the blood chamber, in particular within the blood chamber, in particular the blood inlet side first sub-chamber, generating an oxygen bubble
  • Fumigator is arranged, in particular by a fritted with oxygen frit.
  • Oxygenation of the blood can be generated, wherein the oxygen bubbles are eliminated at the at least one semipermeable membrane from the blood by the suppression in the vacuum chamber hereafter, preferably, however, does not degas the dissolved oxygen in the blood.
  • the pressure in the vacuum chamber is smaller than the ambient pressure, but so that the oxygen partial pressure in the vacuum chamber is greater than the oxygen partial pressure of the dissolved oxygen in the blood.
  • this in turn can be achieved through the
  • the invention can provide in all possible embodiments of the blood chamber and particularly preferably in the aforementioned U-shaped configuration that in the blood chamber, in particular the blood outlet side second
  • Vacuum chamber in particular one of a plurality of vacuum chambers is connected or forms.
  • Each semipermeable hollow fiber forms a semi-permeable membrane, particularly in a tubular configuration.
  • Blood chamber or one or both sub-chambers equal to the number of hollow fibers in this chamber.
  • the invention may provide that in at least one vacuum chamber a bundle is semipermeable
  • Hollow fibers is arranged, the outer surface by suppressing
  • the inner volumes of the hollow fibers form at least a portion of the blood chamber, in particular a part of at least one sub-chamber or the whole.
  • the degassing device as a whole or a partial chamber or both
  • Partial chambers of the above-described embodiment may thus include, for example, a commercially available oxygenator or dialyzer, in particular be formed from this two aforementioned alternative embodiments.
  • the two mentioned embodiments then differ essentially in that the blood either flows outside the hollow fibers and the negative pressure lies in the interior of the hollow fibers or that the blood flows in the interior of the hollow fibers and the negative pressure is applied externally to the hollow fibers.
  • the invention can provide that an oxygen feed opens into the at least one vacuum chamber,
  • the system according to the invention for the extracorporeal treatment of blood comprises a blood collection unit, in particular a blood collection cannula and a blood return unit, in particular a blood return cannula, wherein at least one blood-carrying tube, at least one blood pump and an oxygenator is arranged between the units, in particular so that blood passes through with the at least one blood pump the oxygenator is pumpable.
  • a blood collection unit in particular a blood collection cannula and a blood return unit, in particular a blood return cannula
  • at least one blood-carrying tube, at least one blood pump and an oxygenator is arranged between the units, in particular so that blood passes through with the at least one blood pump the oxygenator is pumpable.
  • this system additionally comprises a degassing device according to one of the above
  • a degassing of blood can be carried out, e.g. from the blood which is being delivered in the circulation of the system or also from blood coming from a surgical field environment by means of a pump, e.g. a hose squeezing pump was sucked off.
  • a pump e.g. a hose squeezing pump was sucked off.
  • the circulated blood can be degassed in the sense that dissolved therein carbon dioxide and / or
  • Carbon monoxide is degassed.
  • the degassing device may be arranged in the circulation upstream of the oxygenator.
  • the design of the system when this is set up, a partial flow of the total blood flowing between the units (blood collection unit and blood return unit) through the
  • Entgasungsaku is continuously integrated into the bloodstream of the system, thus in particular thus not only at the times when a degassing of bubbles of blood is needed. Such is a stagnation of blood in the
  • a further development system can provide that it comprises an inflow line, by means of which the blood laden with gas bubbles from a
  • Surgical field environment is aspirated, in particular with a in the
  • Inflow line arranged blood pump, said inflow line opens into the blood inlet of the degassing device.
  • An embodiment may then be e.g. provide that the blood outlet of the degassing device leads somewhere in the tube of the system in which the blood is circulated, e.g. also downstream from the oxygenator.
  • the invention particularly preferably provides that the blood outlet of the degassing device opens into the blood inlet of the oxygenator. This ensures that the degassed blood is enriched with oxygen in the oxygenator before being returned to the patient.
  • a particularly preferred embodiment of the invention provides that the system is set up to control the generation of negative pressure in the at least one vacuum chamber of the degassing device as a function of the operation of the blood pump of the operating field suction, preferably the blood pump in the inflow line, in particular such that automatically a negative pressure in the at least one vacuum chamber is generated, as soon as or before the blood pump surgical field suction goes into operation, more preferably wherein an ambient pressure prevails in the at least one vacuum chamber as soon as or after this blood pump has gone out of service.
  • Degassing device is present when a blood suction from the
  • a method for extracorporeal preparation of blood which has been taken from a human or animal body is characterized in that gas present in the blood, preferably gas bubbles, is eliminated by virtue of the blood being attached to one side of a semipermeable membrane is guided along, wherein the other side of the semipermeable membrane is subjected to a negative pressure, preferably with a suppressed oxygen atmosphere.
  • FIG. 1 shows a first possible embodiment of a device according to the invention
  • Degassing device comprising a blood chamber 1 can be passed through the blood via the blood inlet 2 and the blood outlet 3.
  • a plurality of semipermeable hollow fibers 4 are arranged, the outer side of which is in contact with the blood in the blood chamber 1 and the hollow interior of which is set by means of at least one vacuum pump 5 to be suppressed.
  • all the open ends of the hollow fibers together open into a chamber which is supplied with negative pressure,
  • the here per vacuum pump 5 via at least one, shown here two negative pressure connections 8 is set under suppression.
  • Each hollow fiber 4 forms a semi-permeable membrane.
  • a semipermeable, preferably microporous flat membrane 4a is arranged, which separates the blood chamber 1 with respect to a further vacuum chamber 1 1, which is supplied by a further vacuum pump 5 with negative pressure.
  • Flat membrane 4a may have a longitudinal extent corresponding to the length of the hollow fibers 4.
  • oxygen is introduced into the vacuum chamber via an oxygen supply 7 in order to produce the suppression in a predominantly oxygen-containing atmosphere, with the advantages described above.
  • the device shown in Figure 1 may be formed by an oxygenator or dialyzer, to which e.g. to the gas outlet 8 or the gas outlets 8, a vacuum pump 5 is connected. This gas outlet 8 thus forms the vacuum connection 8.
  • FIG. 2 shows a preferred embodiment in which the blood supply 2 and the connections of the vacuum pump 5 and the oxygen supply 7 are reversed. Accordingly, the blood is guided in the interior of the hollow fibers 4 here relative to the figure 1 and the negative pressure is applied to the outside of the hollow fibers 4. Otherwise, the function is identical to Figure 1.
  • the blood chamber 1 is formed here by the sum of the inner volumes of the hollow fibers 4 and the
  • Vacuum chamber 1 1 by the volume around it, in particular which is limited by the outer housing of the device.
  • FIG. 3 shows an embodiment in which the blood chamber 1 of FIG. 3
  • Degassing device is divided into two sub-chambers 1 a and 1 b, which are thus arranged perpendicular to the direction of gravity horizontally side by side, the blood flow in each of the sub-chamber in the middle parallel to the direction of gravity, namely in the sub-chamber 1 a from the blood inlet against the direction of gravity up and in the sub-chamber 1 b in the direction of gravity to the blood outlet third
  • the upper ends of the sub-chambers 1 a and 1 b are connected by a substantially horizontal bridging region 9, in which the blood is transferred on average horizontally from the first sub-chamber 1 a to the second sub-chamber 1 b.
  • This bridging area 9 is defined by a semipermeable membrane 10, e.g. a flat membrane is divided into a lower region, which is part of the blood chamber, that is, flows through the blood and an upper portion which forms the vacuum chamber 11, to which the vacuum pump 5 is connected.
  • a semipermeable membrane 10 e.g. a flat membrane is divided into a lower region, which is part of the blood chamber, that is, flows through the blood and an upper portion which forms the vacuum chamber 11, to which the vacuum pump 5 is connected.
  • the membrane 10 By the negative pressure, the membrane 10 is curved upwards and forms the highest point of blood flow in the blood chamber in the upper part of the curvature. Existing gas bubbles will thus accumulate here due to buoyancy and will be eliminated. An outflow of non-eliminated gas bubbles from the blood chamber is further prevented by the
  • Gas bubbles are prevented by their buoyancy of a downward flow in the second sub-chamber 1 b, thus thus remain until complete elimination in the blood chamber.
  • FIG. 4 shows a development of the embodiment of FIG. 3.
  • semipermeable hollow fibers 4 are arranged at least in the second sub-chamber 1 b, as has already been described for FIG. These are oppressed from the inside and flows around the outside of the blood.
  • this degassing device has a blood chamber with the two sub-chambers 1 a / 1 b and the bridging region 9 and two
  • Vacuum chambers namely a vacuum chamber 11 above the membrane 10 in the bridging region 9 and one, the sum of the inner
  • Volumes of the hollow fibers 4 is optionally formed plus a chamber area in which the open ends of the hollow fibers 4 open.
  • Both vacuum chambers may be provided with vacuum by separate vacuum pumps or other vacuum source.
  • provision may also be made for oxygen to be introduced into the vacuum chamber (s) in order to form the suppression in a predominantly or only oxygen-containing atmosphere.
  • FIG. 4 further shows that there is the possibility of integrating an oxygen feed 12 into the region of the blood inlet 2, as a result of which
  • Oxygen bubbles 13 can be formed for oxygenation in the blood.
  • Oxygen bubbles 13 can be provided here with a fragrant stream of oxygen.
  • At the top
  • FIG. 5 shows an embodiment in which semipermeable hollow fibers 4 are arranged both in the first sub-chamber 1 a and in the second sub-chamber 1 b.
  • Oxygen supply to the blood chamber which could also be provided.
  • Hollow fibers 4 prevails in the embodiments of Figures 4 and 5 also be such that the blood flows in the hollow fibers 4 and the negative pressure is present outside the hollow fibers.
  • the latter is the preferred embodiment of the embodiments of FIGS. 4 and 5. This results in no visual difference in FIGS. 4 and 5.
  • Figures 6a and 6b show a possible system used in performing operations on a subject, e.g. a person can be used.
  • the system includes
  • the system comprises a blood collection unit, e.g. a cannula 20, with the venous blood taken from the patient P and in the blood-carrying tube 21 by a blood pump 22 and an oxygenator 23 to the
  • Blood return unit such as a cannula 24 is performed.
  • a blood circulation is formed for oxygenation of the pumped blood.
  • a partial flow of the blood is removed from the tube 21 in front of the oxygenator 23 and passed over the degassing device according to the invention, which is provided here overall with the reference numeral 25 and one of
  • the degassed blood is returned here in the tube 21 and that in this embodiment downstream of the oxygenator.
  • the degassing device thus forms a bypass is continuously flowed through by blood.
  • FIG. 6 a shows an application in which the degassing device 25 is not provided with negative pressure by the vacuum pump 5. This is e.g. not connected to the vacuum chamber.
  • FIG. 6b shows the application in which blood is sucked out of a surgical field by means of a blood pump 26 and an inflow line 27, which can thus contain gas bubbles of the ambient air.
  • This blood is guided via the inflow line 27 into the blood inlet 2 of the degassing device 25 and is freed of gas bubbles therein, after which the blood is guided from the blood outlet 3 downstream of the oxygenator into the tube 21.
  • the degassed blood is thus passed by the oxygenator.
  • a blood volume depot 21 a can be set up in the tube 21 in the system, which, however, is insignificant for the invention.
  • FIGS. 7a and 7b describe a system as in FIGS. 6 but with the difference that the partial flow of the circulated blood passed through the degassing device 25 downstream of the degassing device 25
  • Oxygen can be enriched by the oxygenator 23.
  • FIG. 7a again shows the application in which the degassing device is operated only in partial flow without a connected negative pressure in the vacuum chamber.
  • Figure 7b visualizes the pumping of blood from the
  • Figure 7b visualizes an embodiment in which a control device 29 is provided, via which the blood pump 26 for the suction of blood from the surgical field and the vacuum pump 5 for generating the negative pressure in the vacuum chamber of the degassing 25 are controlled depending on each other.
  • Such control may be arranged to allow the blood pump 26 to be e.g. only begins with the suction, so goes into operation when the vacuum pump 5 is already in operation and a suppression for bubble elimination is already established safely in the degassing.
  • the controller may also cause the vacuum pump to go out of operation only when the blood pump 26 is off and no longer delivering.
  • Other operating dependencies can also be stored here.
  • Such a control may also be provided in the system according to FIG. 6, but is not visualized there.

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • External Artificial Organs (AREA)

Abstract

L'invention concerne un dispositif de dégazage (25) pour le dégazage de sang comprenant une chambre à sang (1, 1a, 1b) comprenant une entrée de sang (2) et une sortie de sang (3), par lesquelles du sang est/peut être passé à travers la chambre à sang (1, 1a, 1b), au moins une chambre de dépression (11) comprenant un raccord de dépression (8), à travers lequel l'au moins une chambre de dépression (11) est mise en dépression, au moins une membrane semi-perméable (4, 4a) qui est disposée entre la chambre de dépression (11) et la chambre à sang (1), la chambre à sang (1) comprenant une première et une deuxième chambre partielle (1a, 1b), qui sont disposées l'une à côté de l'autre dans une direction perpendiculaire à la direction de la pesanteur, et une zone de pontage (9) qui connecte les deux chambres partielles (1a, 1b) sur leur extrémité supérieure, l'entrée de sang (2) étant disposée dans la zone inférieure de la première chambre partielle (1a) et la sortie de sang (3) étant disposée dans la zone inférieure de la deuxième chambre partielle (1b). L'invention concerne aussi un système pour le traitement extracorporel de sang.
EP19712974.5A 2018-03-22 2019-03-20 Dispositif de dégazage pour du sang et système pour le traitement de sang Withdrawn EP3768351A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102018002385.1A DE102018002385A1 (de) 2018-03-22 2018-03-22 Entgasungsvorrichtung für Blut
PCT/EP2019/056974 WO2019180088A1 (fr) 2018-03-22 2019-03-20 Dispositif de dégazage pour du sang et système pour le traitement de sang

Publications (1)

Publication Number Publication Date
EP3768351A1 true EP3768351A1 (fr) 2021-01-27

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EP19712974.5A Withdrawn EP3768351A1 (fr) 2018-03-22 2019-03-20 Dispositif de dégazage pour du sang et système pour le traitement de sang

Country Status (4)

Country Link
US (1) US20210106745A1 (fr)
EP (1) EP3768351A1 (fr)
DE (1) DE102018002385A1 (fr)
WO (1) WO2019180088A1 (fr)

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DE102018008459A1 (de) * 2018-10-29 2020-04-30 Enmodes Gmbh Vorrichtung für den Stoffaustausch zwischen Blut- und wenigstens einem Gas/Gasgemisch
WO2021064441A1 (fr) * 2019-10-03 2021-04-08 Sorin Group Italia S.R.L. Systèmes et procédés pour éliminer des micro-emboles gazeux présents dans le sang
DE102020112224A1 (de) * 2020-05-06 2021-11-11 Fresenius Medical Care Deutschland Gmbh Entgasungsvorrichtung

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DE102018002385A1 (de) 2019-09-26
WO2019180088A1 (fr) 2019-09-26

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