EP3756670A4 - Composition granulaire, procédé de production d'une composition granulaire et procédé d'amélioration de la propriété d'élution d'une composition granulaire - Google Patents
Composition granulaire, procédé de production d'une composition granulaire et procédé d'amélioration de la propriété d'élution d'une composition granulaire Download PDFInfo
- Publication number
- EP3756670A4 EP3756670A4 EP19756715.9A EP19756715A EP3756670A4 EP 3756670 A4 EP3756670 A4 EP 3756670A4 EP 19756715 A EP19756715 A EP 19756715A EP 3756670 A4 EP3756670 A4 EP 3756670A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- granular composition
- producing
- elution property
- improving elution
- improving
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000010828 elution Methods 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Glanulating (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018029093 | 2018-02-21 | ||
| PCT/JP2019/006317 WO2019163822A1 (fr) | 2018-02-21 | 2019-02-20 | Composition granulaire, procédé de production d'une composition granulaire et procédé d'amélioration de la propriété d'élution d'une composition granulaire |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP3756670A1 EP3756670A1 (fr) | 2020-12-30 |
| EP3756670A4 true EP3756670A4 (fr) | 2021-11-03 |
Family
ID=67687749
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP19756715.9A Pending EP3756670A4 (fr) | 2018-02-21 | 2019-02-20 | Composition granulaire, procédé de production d'une composition granulaire et procédé d'amélioration de la propriété d'élution d'une composition granulaire |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20200397700A1 (fr) |
| EP (1) | EP3756670A4 (fr) |
| JP (2) | JP7430629B2 (fr) |
| KR (1) | KR20200123447A (fr) |
| CN (1) | CN112055591A (fr) |
| AR (1) | AR114399A1 (fr) |
| AU (1) | AU2019225516A1 (fr) |
| BR (1) | BR112020016230A2 (fr) |
| CA (1) | CA3091584A1 (fr) |
| CL (1) | CL2020002129A1 (fr) |
| CO (1) | CO2020011034A2 (fr) |
| EC (1) | ECSP20057951A (fr) |
| IL (1) | IL276732A (fr) |
| MA (1) | MA51913A (fr) |
| MX (1) | MX2020008695A (fr) |
| PE (1) | PE20210448A1 (fr) |
| PH (1) | PH12020551285A1 (fr) |
| RU (1) | RU2020130411A (fr) |
| SG (1) | SG11202007967YA (fr) |
| TW (1) | TW201936175A (fr) |
| WO (1) | WO2019163822A1 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3154802A1 (fr) * | 2019-10-23 | 2021-04-29 | Marc Patrik SCHRADER | Composition pharmaceutique comprenant du selexipag |
| WO2021206159A1 (fr) * | 2020-04-10 | 2021-10-14 | 日本新薬株式会社 | Préparation solide et son procédé de fabrication |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006043025A1 (fr) * | 2004-10-19 | 2006-04-27 | Reckitt Benckiser Healthcare (Uk) Limited | Compositions granulaires comprenant des granules de fusion solidifies d’un inhibiteur selectif de cox-2 |
| WO2017121806A1 (fr) * | 2016-01-15 | 2017-07-20 | Sandoz Ag | Composition pharmaceutique de selexipag |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2654197B2 (ja) * | 1989-09-25 | 1997-09-17 | 三菱電機株式会社 | スターリングエンジンの圧縮機駆動装置 |
| WO2002024168A1 (fr) * | 2000-09-25 | 2002-03-28 | Nippon Shinyaku Co., Ltd. | Procede de production d'une dispersion solide medicinale |
| TWI316055B (fr) | 2001-04-26 | 2009-10-21 | Nippon Shinyaku Co Ltd | |
| ATE405170T1 (de) * | 2003-05-06 | 2008-09-15 | Gumlink As | Methode zur herstellung von kaugummigranulat und komprimierten kaugummiprodukten, sowie ein kaugummigranuliersystem |
| PL2447254T3 (pl) * | 2009-06-26 | 2018-05-30 | Nippon Shinyaku Co., Ltd. | Kryształy |
| AU2016366073B2 (en) | 2015-12-02 | 2021-08-26 | Nippon Shinyaku Co., Ltd. | Pharmaceutical composition containing 2-{4-[N-(5,6- diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}-N- (methylsulfonyl)acetamide |
-
2019
- 2019-02-20 US US16/971,355 patent/US20200397700A1/en active Pending
- 2019-02-20 EP EP19756715.9A patent/EP3756670A4/fr active Pending
- 2019-02-20 AR ARP190100423A patent/AR114399A1/es unknown
- 2019-02-20 SG SG11202007967YA patent/SG11202007967YA/en unknown
- 2019-02-20 CA CA3091584A patent/CA3091584A1/fr active Pending
- 2019-02-20 TW TW108105520A patent/TW201936175A/zh unknown
- 2019-02-20 CN CN201980014530.2A patent/CN112055591A/zh active Pending
- 2019-02-20 AU AU2019225516A patent/AU2019225516A1/en active Pending
- 2019-02-20 MX MX2020008695A patent/MX2020008695A/es unknown
- 2019-02-20 WO PCT/JP2019/006317 patent/WO2019163822A1/fr unknown
- 2019-02-20 PE PE2020001259A patent/PE20210448A1/es unknown
- 2019-02-20 BR BR112020016230-2A patent/BR112020016230A2/pt unknown
- 2019-02-20 KR KR1020207026724A patent/KR20200123447A/ko not_active Application Discontinuation
- 2019-02-20 RU RU2020130411A patent/RU2020130411A/ru unknown
- 2019-02-20 MA MA051913A patent/MA51913A/fr unknown
- 2019-02-20 JP JP2020500991A patent/JP7430629B2/ja active Active
-
2020
- 2020-08-16 IL IL276732A patent/IL276732A/en unknown
- 2020-08-18 CL CL2020002129A patent/CL2020002129A1/es unknown
- 2020-08-20 PH PH12020551285A patent/PH12020551285A1/en unknown
- 2020-09-03 CO CONC2020/0011034A patent/CO2020011034A2/es unknown
- 2020-09-17 EC ECSENADI202057951A patent/ECSP20057951A/es unknown
-
2023
- 2023-09-26 JP JP2023163205A patent/JP2023182650A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006043025A1 (fr) * | 2004-10-19 | 2006-04-27 | Reckitt Benckiser Healthcare (Uk) Limited | Compositions granulaires comprenant des granules de fusion solidifies d’un inhibiteur selectif de cox-2 |
| WO2017121806A1 (fr) * | 2016-01-15 | 2017-07-20 | Sandoz Ag | Composition pharmaceutique de selexipag |
Non-Patent Citations (1)
| Title |
|---|
| "Amorphous Selexipag Formulations", RESEARCH DISCLOSURE, KENNETH MASON PUBLICATIONS, HAMPSHIRE, UK, GB, vol. 618, no. 27, 1 October 2015 (2015-10-01), pages 2, XP007144400, ISSN: 0374-4353, [retrieved on 20150909] * |
Also Published As
| Publication number | Publication date |
|---|---|
| BR112020016230A2 (pt) | 2020-12-08 |
| PE20210448A1 (es) | 2021-03-08 |
| MA51913A (fr) | 2020-12-30 |
| RU2020130411A (ru) | 2022-03-21 |
| CN112055591A (zh) | 2020-12-08 |
| WO2019163822A1 (fr) | 2019-08-29 |
| JPWO2019163822A1 (ja) | 2021-02-04 |
| JP2023182650A (ja) | 2023-12-26 |
| US20200397700A1 (en) | 2020-12-24 |
| CA3091584A1 (fr) | 2019-08-29 |
| ECSP20057951A (es) | 2020-10-30 |
| CO2020011034A2 (es) | 2020-12-10 |
| AR114399A1 (es) | 2020-09-02 |
| CL2020002129A1 (es) | 2021-02-05 |
| JP7430629B2 (ja) | 2024-02-13 |
| TW201936175A (zh) | 2019-09-16 |
| AU2019225516A1 (en) | 2020-10-08 |
| PH12020551285A1 (en) | 2021-05-31 |
| IL276732A (en) | 2020-09-30 |
| RU2020130411A3 (fr) | 2022-03-21 |
| MX2020008695A (es) | 2020-09-25 |
| EP3756670A1 (fr) | 2020-12-30 |
| SG11202007967YA (en) | 2020-09-29 |
| KR20200123447A (ko) | 2020-10-29 |
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