EP3697371A1 - Oil-in-water emulsion based on essential oils, and formulated without surfactant - Google Patents

Oil-in-water emulsion based on essential oils, and formulated without surfactant

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Publication number
EP3697371A1
EP3697371A1 EP18796739.3A EP18796739A EP3697371A1 EP 3697371 A1 EP3697371 A1 EP 3697371A1 EP 18796739 A EP18796739 A EP 18796739A EP 3697371 A1 EP3697371 A1 EP 3697371A1
Authority
EP
European Patent Office
Prior art keywords
composition
composition according
surfactant
oil
hydrosol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP18796739.3A
Other languages
German (de)
French (fr)
Inventor
Isabelle Desjardins-Lavisse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genialis Biotech SAS
Original Assignee
Genialis Biotech SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genialis Biotech SAS filed Critical Genialis Biotech SAS
Publication of EP3697371A1 publication Critical patent/EP3697371A1/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/062—Oil-in-water emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/10—General cosmetic use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30—Characterized by the absence of a particular group of ingredients
    • A61K2800/33—Free of surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/82—Preparation or application process involves sonication or ultrasonication

Definitions

  • the present invention relates to the field of oil-in-water emulsions and more particularly proposes oil-in-water emulsions based on essential oils formulated without surfactant or any other substitute substance.
  • patents FR27221 16 and FR2720644 propose, for their part, examples of use of solid particles which ensure the dispersion of one of the two phases in the other. These particles also have the advantage of offering product textures that are more advantageous for the consumer.
  • Other solutions are proposed by patents CA2295533 and FR2771293, which respectively describe the use of a cationic gel and a lipophilic agent whose HLB (hydrophilic / lipophilic balance) is less than 3. The stability of the preparations made is then ensured by the structuring that allow these compounds at the hydrophilic / lipophilic interface.
  • Dispersions or emulsions containing alcohol Dispersions or emulsions containing alcohol
  • the invention relates to very simple compositions, consisting of an emulsion of an essential oil in an aqueous solution, this aqueous solution preferably being a hydrosol.
  • these compositions are stable in the absence of any surfactant molecule and pleasant to use.
  • These compositions containing only essential oils and an aqueous phase constitute a new and innovative galenic.
  • the present invention relates to novel short and single galenical formulations of essential oils (HE) for use in aromatherapy.
  • These formulations constitute stable emulsions of HE in an aqueous solution without addition of surfactant.
  • Such emulsions can be obtained for example using the method using high frequency ultrasound, as described in the patent application WO2010 / 149668.
  • This preparation process makes it possible in particular to prepare a stable oil-in-water emulsion.
  • This method combines a lipid phase with an aqueous phase by subjecting the mixture to vibratory energy, in a closed container, by applying a transducer operating in a frequency range between 900 kHz and 3 MHz. In a preferred embodiment, the transducer operates at a higher frequency or equal to 1 MHz.
  • a first subject of the invention therefore relates to an oil-in-water emulsion composition
  • an oil-in-water emulsion composition comprising an aqueous solution and at least one HE, this composition not containing a surfactant and being obtained by an ultrasonic treatment whose vibration frequency is greater or equal to 1 MHz.
  • compositions do not contain surfactant, emulsifier or any other substance or particle intended to stabilize the preparation with respect to phase separation.
  • aqueous solution used to prepare the emulsion can be diverse. It is preferably an aqueous solution containing plant extracts, in particular a hydrosol, an infusion or a maceration of plants, or a fruit water.
  • the aqueous solution is a hydrolate, pure or diluted, or a mixture of hydrolates.
  • the quantity of HE contained in the compositions must be adapted so that the finished products can be used directly, for example in topical application, without presenting a risk for the users (irritations, itching, or even burns caused by HE in overdose).
  • the proportion of HE contained in the compositions is generally less than 3%, for example 1%, 1, 5%, 2% or 2.5%.
  • the amount of HE will be 2%.
  • the oily phase is provided solely by the HE, to the exclusion of any other vegetable oil.
  • the invention relates to compositions consisting of an emulsion of one or more HE in one or more aqueous solutions, in particular in one or more hydrosols.
  • the composition contains a hydrolate and an HE from the same plant.
  • This embodiment is particularly interesting because it makes it possible to propose an integral plant preparation comprising all the components extracted from the plant. Indeed, during the distillation of a plant on the one hand ⁇ and on the other hand the hydrolate (or distillation water) whose compositions are different, beyond the fact that ⁇ is a very concentrated extract relative to the hydrolate.
  • composition comprising:
  • an EO of pink and a hydrosol of rose preferably 2% of EO of pink.
  • peppermint EO and peppermint hydrosol preferably 2% peppermint EO
  • tea tree HE a tea tree HE and a tea tree hydrosol, preferably 2% of tea tree HE.
  • the hydrolate and ⁇ may be the only ingredients.
  • emulsions can be obtained from a mixture of aqueous solutions and / or a mixture of HE or from emulsions mixed with each other.
  • Emulsions containing aqueous solution and HEs, excluding any texturizing agent, are liquid. So as to facilitate handling and use, gelling agents may be added without this denatures the emulsion, including its properties.
  • compositions according to the invention may contain gelling agents, preferably of natural origin, such as xanthan gum or alginates.
  • gelling agents preferably of natural origin, such as xanthan gum or alginates.
  • the addition of gelling agents respects the naturalness and purity of the product and makes it possible to obtain a creamier and more pleasant texture when applied to the skin.
  • the texture of the composition will depend on the amount of gelling agent added.
  • the proportion of gelling agent will generally be less than 0.1%, preferably absent from the composition.
  • the proportion of gelling agent will generally be between 0.1% and 0.8% of the composition.
  • the proportion of gelling agent will generally be between 0.8% and 2% of the composition.
  • the proportion of gelling agent will generally be between 2% and 5% of the composition.
  • the gelling agents are added after emulsification according to the desired texture.
  • moisturizing agents preferably of natural origin can be added to the composition, for example glycerin.
  • moisturizing agents When moisturizing agents are added, their proportion is generally between 2% and 10% of the composition. In general, the moisturizing agents may be added before or after emulsification; however, if the agents are hydrophobic, they will be added before emulsification.
  • compositions according to the invention do not contain a preservative. They are protected from microbial growth because of the presence of HE in the composition. The advantages of the compositions of the invention are numerous.
  • compositions are natural and healthy and they have less allergenic risk.
  • the compositions can be 100% organic. They also have other very interesting properties. The inventors have indeed shown that the activity of the active ingredients is preserved in the emulsified compositions without surfactant and that the effectiveness of the compositions (without surfactant) is higher than that of the products with surfactants, in proportion to equivalent active ingredients.
  • compositions are stable. Their stability is ensured by the method, in particular and preferably by an ultrasound treatment whose vibration frequency is greater than or equal to 1 MHz, as described in the patent WO2010 / 149668. Their stability at room temperature is observed for at least 3 months and up to more than 12 months.
  • compositions according to the invention are compositions for topical use that can be used in humans or animals.
  • the aqueous solution of the composition is water and is a mixture of katafray HE, camphor rosemary HE, lemon eucalyptus HE and juniper EO. common.
  • An example of such a composition is described in Example 1; it has the effect of causing heating after topical application.
  • Such a composition is in the form of a lotion preparatory to the muscular effort.
  • a second object of the invention relates to the use of a composition containing an oil-in-water emulsion based on a mixture of katafray HE, camphor rosemary, lemon eucalyptus and common juniper. as a preparation lotion for muscular effort.
  • FIGURES
  • FIGURE 1 presents a comparison of heating on skin with the application of the composition A (without surfactant, curve marked with the squares) with the composition A-TS (with surfactant, curve marked with circles).
  • Composition A is prepared using the method described in Application WO2010 / 149668 and defined below:
  • Table 1 Ingredients of the composition "preparation for the effort" An A-TS composition was prepared using the same method and using the same ingredients as for Composition A, with the difference that 1% Twin 80 is added as a surfactant. b. Measurement of the heating effect of the product "preparation for the effort"
  • composition A In order to evaluate the heating effect of composition A, it was applied to the arm of healthy subjects. The test was performed as follows:
  • a defined area of the subject's arm was spotted and cleaned (with soap, then rinsed and dried).
  • the application surface is about 9 cm 2 , a square of 3 cm side).
  • the graph shows a rise in temperature during the first 5 minutes after application, to reach a maximum corresponding to a temperature increase of 2.2 ° C. The temperature then decreases gradually, remaining still one degree higher than the temperature of the zone before application.
  • composition A to induce a heating in the skin and thus also the muscle underlying the area tested.
  • Such a composition can therefore be used as a preparation product for muscular effort, by topical application to the muscles that will be stressed. c. Comparison of the effectiveness of composition A with that of a composition
  • A-TS containing surfactants In order to evaluate the effectiveness of the formulation without surfactant, a comparative study was carried out using in parallel a product having the same components as composition A and prepared with the same process but to which surfactants were added; this composition is called A-TS composition.
  • FIG. 1 represents the temperature increase obtained after topical application of these two compositions. While the composition A allows a temperature increase of more than 2 ° C. (as described in the previous paragraph), the composition A-TS (curve A-TS) induces a very limited rise in temperature, generally less than 0.5 ° C.
  • composition A formulated without surfactant is more effective to cause heating, the composition A-TS comprising a surfactant, while these two compositions have the same proportion of active ingredients. There is therefore a better activity of the active ingredients in a formulation without surfactant compared to the same dose of active ingredients in the presence of surfactant. This observation highlights the fact that a formulation without surfactant allows a better bioavailability of the active ingredients.
  • An integral peppermint gel preparation according to the invention can be obtained from the following ingredients:
  • Table 2 Composition of an integral gel of peppermint
  • Both ingredients are emulsified under high frequency vibration, as described in patent application WO2010 / 149668.
  • the pH of the preparation is then adjusted to 7, if necessary.
  • a texturizer may optionally be added to the emulsion so as to obtain a texture that is less liquid and easier to apply. It is also possible to add to this composition, without modifying the properties of interest, a preservative and an antioxidant in respective proportions to ensure the non-degradation of the product over time.
  • Example 2 Remarkably and similar to the observations of Example 1, a stable equivalent product (prepared without high frequency vibration treatment) can not be obtained without the addition of surfactant. In addition, a product prepared with the same protocol but containing in addition a surfactant will be less effective.
  • the product according to the invention can be used directly for conventional applications of peppermint essential oil (headaches, digestion, etc.). In topical use, it does not require additional dilution. In particular, no dilution in an oil is necessary. The touch of the product is completely aqueous and its application therefore leaves no unpleasant feeling of stickiness and fat.
  • An integral lavender gel preparation according to the invention can be obtained from the following ingredients:
  • Both ingredients are emulsified under high frequency vibration, as described in patent application WO2010 / 149668.
  • the pH of the preparation is then adjusted to 7, if necessary.
  • a texturizer may optionally be added to the emulsion so as to obtain a texture that is less liquid and easier to apply. It is also possible to add to this formula, without changing its properties of interest, a preservative and an antioxidant in respective proportions to ensure the non-degradation of the product over time.
  • the product according to the invention can be used directly for conventional applications of essential oil of lavender aspic (burns, insect bites, etc.). In topical use, it does not require additional dilution. In particular, no dilution in an oil is necessary. The touch of the product is completely aqueous and its application therefore leaves no unpleasant feeling of stickiness and fat.
  • EXAMPLE 4 Formulation of an integral tea tree gel
  • a tea tree integral gel preparation according to the invention can be obtained from the following ingredients:
  • Table 4 Composition of an integral tea tree gel
  • Both ingredients are emulsified under high frequency vibration, as described in patent application WO2010 / 149668.
  • the pH of the preparation is then adjusted to 7, if necessary.
  • a texturizer may optionally be added to the emulsion so as to obtain a texture that is less liquid and easier to apply. It is also possible to add to this formula, without modifying the properties of interest, a preservative and an antioxidant in respective proportions to ensure the non-degradation of the product over time. Remarkably and similar to the observations of the previous examples, a stable equivalent product (prepared without high frequency vibration processing) can not be obtained without the addition of surfactant. In addition, a product prepared with the same protocol but containing in addition a surfactant will be less effective.
  • the product according to the invention can be used directly for conventional applications of tea tree essential oil (sore throat, acne, antiseptic, etc.). In topical use, it does not require additional dilution. In particular, no dilution in an oil is necessary. The touch of the product is completely aqueous and its application therefore leaves no unpleasant feeling of stickiness and fat.
  • tea tree essential oil saliva throat, acne, antiseptic, etc.

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Abstract

The present invention relates to the field of oil-in-water emulsions and more particularly to oil-in-water emulsions containing essential oils and formulated without a surfactant or any other substitute substance.

Description

EMULSION HUILE-DANS-EAU A BASE D'HUILES ESSENTIELLES ET  OIL-IN-WATER EMULSION BASED ON ESSENTIAL OILS AND
FORMULEE SANS TENSIO-ACTIF  FORMULATED WITHOUT SURFACTANTS
La présente invention concerne le domaine des émulsions huile-dans-eau et propose plus particulièrement des émulsions huile-dans-eau à base d'huiles essentielles formulées sans tensioactif, ni aucune autre substance de substitution. The present invention relates to the field of oil-in-water emulsions and more particularly proposes oil-in-water emulsions based on essential oils formulated without surfactant or any other substitute substance.
ART ANTERIEUR La préparation d'émulsions sans tensio-actif est un sujet d'intérêt dans les domaines de la cosmétique et de la pharmacopée depuis de nombreuses années. La plupart des solutions proposées à ce jour concernent l'utilisation de substances particulières, non classées parmi les tensio-actifs, mais dont le rôle dans la formulation est d'en compenser l'absence. Le brevet US6,416,748 propose par exemple l'utilisation d'un polymère réticulé d'au moins un monomère à insaturation éthylénique, alors que le brevet FR2750327 propose d'utiliser un poly(acide 2-acrylamido 2-méthylpropane sulfonique) réticulé et neutralisé. Ces solutions sont ainsi basées sur l'utilisation de molécules de taille importante, qui stabilisent l'émulsion par la structuration qu'elles imposent à leur milieu. Les brevets FR27221 16 et FR2720644 proposent, quant à eux, des exemples d'utilisation de particules solides qui assurent la dispersion d'une des deux phases dans l'autre. Ces particules présentent également l'avantage d'offrir des textures produit plus avantageuses pour le consommateur. D'autres solutions sont proposées par les brevets CA2295533 et FR2771293, lesquels décrivent respectivement l'utilisation d'un gel cationique et d'un agent lipophile dont la HLB (balance hydrophile/lipophile) est inférieur à 3. La stabilité des préparations réalisées est alors assurée par la structuration que permettent ces composés au niveau de l'interface hydrophile/lipophile. PRIOR ART The preparation of emulsions without surfactant has been a subject of interest in the fields of cosmetics and pharmacopoeia for many years. Most of the solutions proposed to date concern the use of particular substances, not classified as surfactants, but whose role in the formulation is to compensate for their absence. US Pat. No. 6,416,748 proposes, for example, the use of a crosslinked polymer of at least one ethylenically unsaturated monomer, while the patent FR2750327 proposes to use a crosslinked and neutralized poly (2-acrylamido-2-methylpropane sulfonic acid). . These solutions are thus based on the use of large molecules, which stabilize the emulsion by structuring that they impose on their environment. The patents FR27221 16 and FR2720644 propose, for their part, examples of use of solid particles which ensure the dispersion of one of the two phases in the other. These particles also have the advantage of offering product textures that are more advantageous for the consumer. Other solutions are proposed by patents CA2295533 and FR2771293, which respectively describe the use of a cationic gel and a lipophilic agent whose HLB (hydrophilic / lipophilic balance) is less than 3. The stability of the preparations made is then ensured by the structuring that allow these compounds at the hydrophilic / lipophilic interface.
Concernant les préparations d'huiles essentielles en particulier, il existe aujourd'hui trois formes galéniques potentiellement sans tensio-actifs afin de les vectoriser : Concerning preparations of essential oils in particular, there are today three galenic forms potentially without surfactants in order to vectorize them:
- Des dispersions ou émulsions contenant de l'alcool ;  Dispersions or emulsions containing alcohol;
- Des dispersions dans des huiles ;  Dispersions in oils;
- Des émulsions contenant des savons. La dispersion directe dans l'eau ou toute autre solution aqueuse n'est pas possible sans disposer de technologies particulières. - Emulsions containing soaps. Direct dispersion in water or any other aqueous solution is not possible without having particular technologies.
AVANTAGES DE L'INVENTION ADVANTAGES OF THE INVENTION
Il apparaît au regard de l'état de l'art antérieur qu'il n'existe pas actuellement de propositions permettant la préparation de produits émulsionnés ne contenant pas de substance, de quelque sorte que ce soit, pour en assurer la stabilité. De plus, la texture des produits contenant des huiles essentielles proposés jusqu'à présent n'est pas satisfaisante. Il serait intéressant de proposer une nouvelle galénique, permettant de disposer de produits à la texture plus agréable, sans effet collant gras à l'application, avec un touché doux et qui sèchent rapidement sur la peau. It appears from the state of the prior art that there are currently no proposals for the preparation of emulsified products containing no substance, of any kind, to ensure stability. In addition, the texture of products containing essential oils proposed so far is not satisfactory. It would be interesting to propose a new galenic, allowing to have products with the texture more pleasant, without greasy sticky effect with the application, with a soft touch and which dry quickly on the skin.
Ainsi, l'invention concerne des compositions très simples, constituées d'une émulsion d'une huile essentielle dans une solution aqueuse, cette solution aqueuse étant de préférence un hydrolat. De manière remarquable, ces compositions sont stables en l'absence de toute molécule tensioactive et agréables à utiliser. Ces compositions ne contenant que des huiles essentielles et une phase aqueuse constituent une galénique nouvelle et innovante. Thus, the invention relates to very simple compositions, consisting of an emulsion of an essential oil in an aqueous solution, this aqueous solution preferably being a hydrosol. Remarkably, these compositions are stable in the absence of any surfactant molecule and pleasant to use. These compositions containing only essential oils and an aqueous phase constitute a new and innovative galenic.
DESCRIPTION DETAILLEE DE L'INVENTION DETAILED DESCRIPTION OF THE INVENTION
La présente invention concerne de nouvelles formulations galéniques courtes et simples d'huiles essentielles (HE) pour une utilisation en aromathérapie. Ces formulations constituent des émulsions stables d'HE dans une solution aqueuse sans ajout de tensioactif. De telles émulsions peuvent être obtenues par exemple à l'aide du procédé mettant en œuvre des ultrasons à haute fréquence, tel que décrit dans la demande de brevet WO2010/149668. Ce procédé de préparation permet notamment la préparation d'une émulsion stable huile dans eau. Ce procédé combine une phase lipidique avec une phase aqueuse en soumettant le mélange à une énergie vibratoire, dans un récipient fermé, par application d'un transducteur opérant dans une plage de fréquences comprises entre 900 kHz et 3 MHz. Dans un mode de réalisation préféré, le transducteur opère à une fréquence supérieure ou égaie à 1 MHz. Un premier objet de l'invention concerne donc une composition de type émulsion huile-dans-eau comprenant une solution aqueuse et au moins une HE, cette composition ne contenant pas de tensioactif et étant obtenue par un traitement ultrasonore dont la fréquence de vibration est supérieure ou égale à 1 MHz. The present invention relates to novel short and single galenical formulations of essential oils (HE) for use in aromatherapy. These formulations constitute stable emulsions of HE in an aqueous solution without addition of surfactant. Such emulsions can be obtained for example using the method using high frequency ultrasound, as described in the patent application WO2010 / 149668. This preparation process makes it possible in particular to prepare a stable oil-in-water emulsion. This method combines a lipid phase with an aqueous phase by subjecting the mixture to vibratory energy, in a closed container, by applying a transducer operating in a frequency range between 900 kHz and 3 MHz. In a preferred embodiment, the transducer operates at a higher frequency or equal to 1 MHz. A first subject of the invention therefore relates to an oil-in-water emulsion composition comprising an aqueous solution and at least one HE, this composition not containing a surfactant and being obtained by an ultrasonic treatment whose vibration frequency is greater or equal to 1 MHz.
Au sens de l'invention, les compositions ne contiennent pas de tensioactif, ni d'émulsifiant, ni aucune autre substance ou particule ayant pour but de stabiliser la préparation vis-à-vis de la séparation de phase. For the purposes of the invention, the compositions do not contain surfactant, emulsifier or any other substance or particle intended to stabilize the preparation with respect to phase separation.
La nature de la solution aqueuse utilisée pour préparer l'émulsion peut être diverse. Il s'agit de préférence d'une solution aqueuse contenant des extraits végétaux, en particulier un hydrolat, une infusion ou une macération de plantes, ou une eau de fruits. Dans un mode de réalisation préféré, la solution aqueuse est un hydrolat, pur ou dilué, ou un mélange d'hydrolats. The nature of the aqueous solution used to prepare the emulsion can be diverse. It is preferably an aqueous solution containing plant extracts, in particular a hydrosol, an infusion or a maceration of plants, or a fruit water. In a preferred embodiment, the aqueous solution is a hydrolate, pure or diluted, or a mixture of hydrolates.
La quantité d'HE contenue dans les compositions doit être adaptée pour que les produits finis puissent être utilisés directement, par exemple en application topique, sans présenter de risque pour les utilisateurs (irritations, démangeaisons, voire brûlures causées par les HE en surdosage). Ainsi, la proportion d'HE contenue dans les compositions est généralement inférieure à 3%, par exemple de 1 %, 1 ,5%, 2% ou 2,5 %. De manière préférée, la quantité d'HE sera de 2%. The quantity of HE contained in the compositions must be adapted so that the finished products can be used directly, for example in topical application, without presenting a risk for the users (irritations, itching, or even burns caused by HE in overdose). Thus, the proportion of HE contained in the compositions is generally less than 3%, for example 1%, 1, 5%, 2% or 2.5%. Preferably, the amount of HE will be 2%.
Dans les compositions de l'invention, la phase huileuse est apportée uniquement par les HE, à l'exclusion de toute autre huile végétale. In the compositions of the invention, the oily phase is provided solely by the HE, to the exclusion of any other vegetable oil.
Dans un mode de réalisation particulier, l'invention concerne des compositions constituées d'une émulsion d'une ou plusieurs HE dans une ou plusieurs solutions aqueuses, en particulier dans un ou plusieurs hydrolats. In a particular embodiment, the invention relates to compositions consisting of an emulsion of one or more HE in one or more aqueous solutions, in particular in one or more hydrosols.
Dans un autre mode de réalisation particulier, la composition contient un hydrolat et une HE issus de la même plante. Ce mode de réalisation est particulièrement intéressant car il permet de proposer une préparation intégrale de plante réunissant tous les composants extraits de la plante. En effet, lors de la distillation d'une plante on obtient d'une part ΙΉΕ et d'autre part l'hydrolat (ou eau de distillation) dont les compositions sont différentes, au-delà du fait que ΙΉΕ est un extrait très concentré par rapport à l'hydrolat. In another particular embodiment, the composition contains a hydrolate and an HE from the same plant. This embodiment is particularly interesting because it makes it possible to propose an integral plant preparation comprising all the components extracted from the plant. Indeed, during the distillation of a plant on the one hand ΙΉΕ and on the other hand the hydrolate (or distillation water) whose compositions are different, beyond the fact that ΙΉΕ is a very concentrated extract relative to the hydrolate.
A titre d'exemple, on peut citer une composition comprenant :  By way of example, there may be mentioned a composition comprising:
- une HE de rose et un hydrolat de rose, de manière préférée 2% d'HE de rose. an EO of pink and a hydrosol of rose, preferably 2% of EO of pink.
- une HE de menthe poivrée et un hydrolat de menthe poivrée, de manière préférée 2% d'HE de menthe poivrée a peppermint EO and peppermint hydrosol, preferably 2% peppermint EO
- une HE de lavande et un hydrolat de lavande, de manière préférée 2% de lavande  an HE of lavender and a hydrosol of lavender, preferably 2% of lavender
- une HE d'arbre à thé et un hydrolat d'arbre à thé, de manière préférée 2% d'HE d'arbre à thé.  a tea tree HE and a tea tree hydrosol, preferably 2% of tea tree HE.
Dans ces compositions, l'hydrolat et ΙΉΕ peuvent être les seuls ingrédients.  In these compositions, the hydrolate and ΙΉΕ may be the only ingredients.
Dans d'autres modes de réalisation, des émulsions peuvent être obtenues à partir d'un mélange de solutions aqueuses et/ou un mélange d'HE ou à partir d'émulsions mélangées entre elles. In other embodiments, emulsions can be obtained from a mixture of aqueous solutions and / or a mixture of HE or from emulsions mixed with each other.
Les émulsions contenant une solution aqueuse et des HE, à l'exclusion de tout agent texturant, sont liquides. De sorte à en faciliter la manipulation et l'utilisation, des agents gélifiants peuvent être ajoutés sans que cela ne dénature l'émulsion, notamment ses propriétés. Emulsions containing aqueous solution and HEs, excluding any texturizing agent, are liquid. So as to facilitate handling and use, gelling agents may be added without this denatures the emulsion, including its properties.
Ainsi, les compositions selon l'invention peuvent contenir des agents gélifiants, de préférence d'origine naturelle, tels que la gomme xanthane ou des alginates. L'ajout d'agents gélifiants respecte la naturalité et la pureté du produit et permet d'obtenir une texture plus crémeuse et plus agréable lors de l'application sur la peau. La texture de la composition dépendra de la quantité d'agent gélifiant ajoutée.  Thus, the compositions according to the invention may contain gelling agents, preferably of natural origin, such as xanthan gum or alginates. The addition of gelling agents respects the naturalness and purity of the product and makes it possible to obtain a creamier and more pleasant texture when applied to the skin. The texture of the composition will depend on the amount of gelling agent added.
Pour obtenir une composition de type lotion, d'aspect liquide, la proportion d'agent gélifiant sera généralement inférieure à 0,1 %, de préférence absente de la composition. Pour obtenir une composition de type lait, d'aspect coulant mais non sprayable, la proportion d'agent gélifiant sera généralement comprise entre 0,1 % et 0,8% de la composition. Pour obtenir une composition de type gel, d'aspect non coulant, la proportion d'agent gélifiant sera généralement comprise entre 0,8% et 2% de la composition. In order to obtain a liquid-type composition of the lotion type, the proportion of gelling agent will generally be less than 0.1%, preferably absent from the composition. In order to obtain a milk-type composition that has a flowable but non-sprayable appearance, the proportion of gelling agent will generally be between 0.1% and 0.8% of the composition. In order to obtain a gel composition of non-flowing appearance, the proportion of gelling agent will generally be between 0.8% and 2% of the composition.
Pour obtenir une composition de type cataplasme ou masque, d'aspect épais et crémeux, la proportion d'agent gélifiant sera généralement comprise entre 2% et 5% de la composition. To obtain a poultice-like composition or mask, of thick and creamy appearance, the proportion of gelling agent will generally be between 2% and 5% of the composition.
La texture étant dépendante de la température, ces indications correspondent à l'aspect des compositions à température ambiante, soit à une température d'environ 20°C, et généralement comprise entre 15°C et 27°C. Since the texture is temperature dependent, these indications correspond to the appearance of the compositions at room temperature, ie at a temperature of about 20 ° C., and generally between 15 ° C. and 27 ° C.
Les agents gélifiants sont ajoutés après émulsification en fonction de la texture souhaitée. The gelling agents are added after emulsification according to the desired texture.
D'autre part, des agents hydratants, de préférence d'origine naturelle peuvent être ajoutés à la composition, par exemple de la glycérine. On the other hand, moisturizing agents, preferably of natural origin can be added to the composition, for example glycerin.
Lorsque des agents hydratants sont ajoutés, leur proportion est généralement comprise entre 2% et 10% de la composition. De manière générale, les agents hydratants peuvent être ajoutés avant ou après émulsification ; toutefois si les agents sont hydrophobes, ils seront ajoutés avant émulsification. When moisturizing agents are added, their proportion is generally between 2% and 10% of the composition. In general, the moisturizing agents may be added before or after emulsification; however, if the agents are hydrophobic, they will be added before emulsification.
Il est également possible d'ajouter, si nécessaire, un correcteur d'acidité pour ajuster le pH de la composition au plus près de celui de la peau. Ce correcteur d'acidité peut être ajouté soit au cours du procédé, soit en fin de procédé. Il est à noter que les compositions selon l'invention ne contiennent pas de conservateur. Elles sont protégées par rapport au développement microbien du fait de la présence d'HE dans la composition. Les avantages des compositions de l'invention sont nombreux. It is also possible to add, if necessary, an acidity corrector to adjust the pH of the composition closer to that of the skin. This acidity corrector can be added either during the process or at the end of the process. It should be noted that the compositions according to the invention do not contain a preservative. They are protected from microbial growth because of the presence of HE in the composition. The advantages of the compositions of the invention are numerous.
Du fait de leur formulation simple, ces compositions sont naturelles et saines et elles présentent moins de risque allergène. Les compositions peuvent être 100% Bio. Elles présentent également d'autres propriétés très intéressantes. Les inventeurs ont en effet montré que l'activité des principes actifs est préservée dans les compositions émulsionnées sans tensioactif et que l'efficacité des compositions (sans tensioactif) est plus élevée que celle des produits avec tensioactifs, à proportion d'ingrédients actifs équivalente.  Because of their simple formulation, these compositions are natural and healthy and they have less allergenic risk. The compositions can be 100% organic. They also have other very interesting properties. The inventors have indeed shown that the activity of the active ingredients is preserved in the emulsified compositions without surfactant and that the effectiveness of the compositions (without surfactant) is higher than that of the products with surfactants, in proportion to equivalent active ingredients.
Enfin, ces compositions sont stables. Leur stabilité est assurée par voie de procédé, notamment et de préférence grâce à un traitement ultrasonore dont la fréquence de vibration est supérieure ou égale à 1 MHz, tel que décrit dans le brevet WO2010/149668. Leur stabilité à température ambiante est observée pendant au moins 3 mois et jusqu'à plus de 12 mois.  Finally, these compositions are stable. Their stability is ensured by the method, in particular and preferably by an ultrasound treatment whose vibration frequency is greater than or equal to 1 MHz, as described in the patent WO2010 / 149668. Their stability at room temperature is observed for at least 3 months and up to more than 12 months.
Les compositions selon l'invention sont des compositions à usage topique utilisables chez l'homme ou les animaux. The compositions according to the invention are compositions for topical use that can be used in humans or animals.
Dans un mode de réalisation particulier, la solution aqueuse de la composition est de l'eau et ΙΉΕ est un mélange d'HE de katafray, d'HE de romarin à camphre, d'HE d'eucalyptus citronné et d'HE de genévrier commun. Un exemple d'une telle composition est décrit à l'Exemple 1 ; elle a pour effet de provoquer un échauffement après application topique. Une telle composition se présente sous la forme d'une lotion préparatoire à l'effort musculaire. In a particular embodiment, the aqueous solution of the composition is water and is a mixture of katafray HE, camphor rosemary HE, lemon eucalyptus HE and juniper EO. common. An example of such a composition is described in Example 1; it has the effect of causing heating after topical application. Such a composition is in the form of a lotion preparatory to the muscular effort.
Ainsi, un deuxième objet de l'invention concerne l'utilisation d'une composition contenant une émulsion huile-dans-eau à base d'un mélange d'HE de katafray, de romarin à camphre, d'eucalyptus citronné et de genévrier commun en tant que lotion préparatoire à l'effort musculaire. FIGURES Thus, a second object of the invention relates to the use of a composition containing an oil-in-water emulsion based on a mixture of katafray HE, camphor rosemary, lemon eucalyptus and common juniper. as a preparation lotion for muscular effort. FIGURES
FIGURE 1 : présente une comparaison de réchauffement sur peau à l'application de la composition A (sans tensioactif ; courbe marquée avec les carrés) avec la composition A-TS (avec tensioactif ; courbe marquée avec les ronds). FIGURE 1: presents a comparison of heating on skin with the application of the composition A (without surfactant, curve marked with the squares) with the composition A-TS (with surfactant, curve marked with circles).
EXEMPLES EXAMPLES
EXEMPLE 1 : Caractéristiques d'un produit de type émulsion huile-dans-eau comprenant des huiles essentielles et dépourvu de tensio-actif a. Composition du produit « préparation à l'effort » : composition A EXAMPLE 1 Characteristics of an Oil-in-Water Emulsion Product Product Comprising Essential Oils and Without Surfactant a. Composition of the product "preparation for the effort": composition A
La composition A est préparée à l'aide du procédé décrit dans la demande WO2010/149668 et définie ci-après : Composition A is prepared using the method described in Application WO2010 / 149668 and defined below:
Tableau 1 : Ingrédients de la composition « préparation à l'effort » Une composition A-TS a été préparée à l'aide du même procédé et en utilisant les mêmes ingrédients que pour la composition A, à la différence que 1 % de Twin 80 est ajouté, en tant que tensio-actif. b. Mesure de l'effet chauffant du produit « préparation à l'effort » Table 1: Ingredients of the composition "preparation for the effort" An A-TS composition was prepared using the same method and using the same ingredients as for Composition A, with the difference that 1% Twin 80 is added as a surfactant. b. Measurement of the heating effect of the product "preparation for the effort"
Afin d'évaluer l'effet chauffant de la composition A, celle-ci a été appliquée sur le bras de sujets sains. Le test a été réalisé de la manière suivante : In order to evaluate the heating effect of composition A, it was applied to the arm of healthy subjects. The test was performed as follows:
1 ) Une zone définie du bras du sujet a été repérée et nettoyée (avec du savon, puis rincée et séchée). La surface d'application correspond à environ 9 cm2, soit un carré de 3 cm de coté). 1) A defined area of the subject's arm was spotted and cleaned (with soap, then rinsed and dried). The application surface is about 9 cm 2 , a square of 3 cm side).
2) La température sur la zone repérée a été mesurée à l'aide d'un thermomètre à infrarouges.  2) The temperature on the marked area was measured using an infrared thermometer.
3) 10mg du produit à tester ont été appliqués sur la zone.  3) 10mg of the product to be tested were applied to the area.
4) La température a été mesurée immédiatement, puis à nouveau à intervalles réguliers (au moins toutes les minutes) pendant 15min.  4) The temperature was measured immediately, then again at regular intervals (at least every minute) for 15min.
Le protocole a été répété sur trois personnes et les données ont été moyennées. Le résultat est présenté sur la Figure 1 (courbe A). The protocol was repeated on three people and the data was averaged. The result is shown in Figure 1 (curve A).
Le graphe montre une élévation de la température pendant les 5 premières minutes après application, pour atteindre un maximum correspondant à une augmentation de la température de 2,2°C. La température redescend ensuite progressivement, restant encore supérieure d'un degré par rapport à la température de la zone avant application. The graph shows a rise in temperature during the first 5 minutes after application, to reach a maximum corresponding to a temperature increase of 2.2 ° C. The temperature then decreases gradually, remaining still one degree higher than the temperature of the zone before application.
Ces résultats montrent l'efficacité de la composition A pour induire un échauffement au niveau de la peau et de ce fait aussi du muscle sous-jacent à la zone testée. Une telle composition peut donc être utilisée en tant que produit de préparation à l'effort musculaire, par application topique au niveau des muscles qui vont être sollicités. c. Comparaison de l'efficacité de la composition A avec celle d'une compositionThese results show the effectiveness of the composition A to induce a heating in the skin and thus also the muscle underlying the area tested. Such a composition can therefore be used as a preparation product for muscular effort, by topical application to the muscles that will be stressed. c. Comparison of the effectiveness of composition A with that of a composition
A-TS contenant des tensioactifs Afin d'évaluer l'efficacité de la formulation sans tensioactif, une étude comparative a été réalisée en utilisant en parallèle un produit présentant les mêmes composants que la composition A et préparée avec le même procédé mais à laquelle on a ajouté des tensioactifs ; cette composition est appelée composition A-TS. A-TS containing surfactants In order to evaluate the effectiveness of the formulation without surfactant, a comparative study was carried out using in parallel a product having the same components as composition A and prepared with the same process but to which surfactants were added; this composition is called A-TS composition.
La figure 1 représente l'augmentation de températures obtenue après application topique de ces deux compositions. Alors que la composition A permet une augmentation de la température de plus de 2°C (comme cela est décrit au paragraphe précédent), la composition A-TS (courbe A-TS) induit une élévation très limitée de la température, globalement inférieure à 0,5°C. FIG. 1 represents the temperature increase obtained after topical application of these two compositions. While the composition A allows a temperature increase of more than 2 ° C. (as described in the previous paragraph), the composition A-TS (curve A-TS) induces a very limited rise in temperature, generally less than 0.5 ° C.
Ces résultats montrent bien que la composition A formulée sans tensioactif est plus efficace pour provoquer un échauffement, que la composition A-TS comprenant un tensioactif, alors que ces deux compositions présentent la même proportion d'ingrédients actifs. On observe donc une meilleure activité des principes actifs dans une formulation sans tensioactif par rapport à une même dose de principes actifs en présence de tensioactif. Cette observation met en évidence le fait qu'une formulation sans tensioactif permet une meilleure biodisponibilité des principes actifs. These results clearly show that the composition A formulated without surfactant is more effective to cause heating, the composition A-TS comprising a surfactant, while these two compositions have the same proportion of active ingredients. There is therefore a better activity of the active ingredients in a formulation without surfactant compared to the same dose of active ingredients in the presence of surfactant. This observation highlights the fact that a formulation without surfactant allows a better bioavailability of the active ingredients.
EXEMPLE 2: Formulation d'un gel intégral de menthe poivrée EXAMPLE 2 Formulation of an Integral Peppermint Gel
Une préparation de gel intégral de menthe poivrée selon l'invention peut être obtenue à partir des ingrédients suivants : An integral peppermint gel preparation according to the invention can be obtained from the following ingredients:
Tableau 2 : Composition d'un gel intégral de menthe poivrée Table 2: Composition of an integral gel of peppermint
Les deux ingrédients sont émulsionnés sous vibration haute fréquence, tel que décrit dans la demande de brevet WO2010/149668. Le pH de la préparation est ensuite ajusté à 7, si nécessaire. Un texturant peut éventuellement être ajouté à l'émulsion de manière à obtenir une texture moins liquide et plus facile à appliquer. Il est également possible d'ajouter à cette composition, sans en modifier les propriétés d'intérêt, un conservateur et un antioxydant dans des proportions respectives permettant d'assurer la non dégradation du produit dans le temps. Both ingredients are emulsified under high frequency vibration, as described in patent application WO2010 / 149668. The pH of the preparation is then adjusted to 7, if necessary. A texturizer may optionally be added to the emulsion so as to obtain a texture that is less liquid and easier to apply. It is also possible to add to this composition, without modifying the properties of interest, a preservative and an antioxidant in respective proportions to ensure the non-degradation of the product over time.
De manière remarquable et similaire aux observations de l'Exemple 1 , un produit équivalent stable (préparé sans traitement par vibration haute fréquence) ne peut pas être obtenu sans ajout de tensioactif. De plus, un produit préparé avec le même protocole mais contenant en plus un tensioactif aura une efficacité moindre.  Remarkably and similar to the observations of Example 1, a stable equivalent product (prepared without high frequency vibration treatment) can not be obtained without the addition of surfactant. In addition, a product prepared with the same protocol but containing in addition a surfactant will be less effective.
Le produit selon l'invention peut être utilisé directement pour des applications classiques de l'huile essentielle de menthe poivrée (maux de tête, digestion, etc.). En usage topique, il ne nécessite pas de dilution supplémentaire. En particulier, aucune dilution dans une huile n'est nécessaire. Le touché du produit est totalement aqueux et son application ne laisse donc aucune sensation désagréable de collant et de gras. The product according to the invention can be used directly for conventional applications of peppermint essential oil (headaches, digestion, etc.). In topical use, it does not require additional dilution. In particular, no dilution in an oil is necessary. The touch of the product is completely aqueous and its application therefore leaves no unpleasant feeling of stickiness and fat.
EXEMPLE 3 : Formulation d'un gel intégral de lavande EXAMPLE 3 Formulation of an Integral Lavender Gel
Une préparation de gel intégral de lavande selon l'invention peut être obtenue à partir des ingrédients suivants : An integral lavender gel preparation according to the invention can be obtained from the following ingredients:
Tableau 3 : composition d'un gel intégral de lavande Table 3: composition of an integral lavender gel
Les deux ingrédients sont émulsionnés sous vibration haute fréquence, tel que décrit dans la demande de brevet WO2010/149668. Le pH de la préparation est ensuite ajusté à 7, si nécessaire. Un texturant peut éventuellement être ajouté à l'émulsion de manière à obtenir une texture moins liquide et plus facile à appliquer. Il est également possible d'ajouter à cette formule, sans en modifier les propriétés d'intérêt, un conservateur et un antioxydant dans des proportions respectives permettant d'assurer la non dégradation du produit dans le temps. Both ingredients are emulsified under high frequency vibration, as described in patent application WO2010 / 149668. The pH of the preparation is then adjusted to 7, if necessary. A texturizer may optionally be added to the emulsion so as to obtain a texture that is less liquid and easier to apply. It is also possible to add to this formula, without changing its properties of interest, a preservative and an antioxidant in respective proportions to ensure the non-degradation of the product over time.
De manière remarquable et similaire aux observations des Exemples précédents, un produit équivalent stable (préparé sans traitement par vibration haute fréquence) ne peut pas être obtenu sans ajout de tensioactif. De plus, un produit préparé avec le même protocole mais contenant en plus un tensioactif aura une efficacité moindre. Remarkably and similar to the observations of the previous Examples, a stable equivalent product (prepared without high frequency vibration processing) can not be obtained without the addition of surfactant. In addition, a product prepared with the same protocol but containing in addition a surfactant will be less effective.
Le produit selon l'invention peut être utilisé directement pour des applications classiques de l'huile essentielle de lavande aspic (brûlures, piqûres d'insectes, etc.). En usage topique, il ne nécessite pas de dilution supplémentaire. En particulier, aucune dilution dans une huile n'est nécessaire. Le touché du produit est totalement aqueux et son application ne laisse donc aucune sensation désagréable de collant et de gras. EXEMPLE 4 : Formulation d'un gel intégral d'arbre à thé The product according to the invention can be used directly for conventional applications of essential oil of lavender aspic (burns, insect bites, etc.). In topical use, it does not require additional dilution. In particular, no dilution in an oil is necessary. The touch of the product is completely aqueous and its application therefore leaves no unpleasant feeling of stickiness and fat. EXAMPLE 4: Formulation of an integral tea tree gel
Une préparation de gel intégral d'arbre à thé selon l'invention peut être obtenue à partir des ingrédients suivants : A tea tree integral gel preparation according to the invention can be obtained from the following ingredients:
Tableau 4: Composition d'un gel intégral d'arbre à thé Table 4: Composition of an integral tea tree gel
Les deux ingrédients sont émulsionnés sous vibration haute fréquence, tel que décrit dans la demande de brevet WO2010/149668. Le pH de la préparation est ensuite ajusté à 7, si nécessaire. Un texturant peut éventuellement être ajouté à l'émulsion de manière à obtenir une texture moins liquide et plus facile à appliquer. Il est également possible d'ajouter à cette formule, sans en modifier les propriétés d'intérêt, un conservateur et un antioxydant dans des proportions respectives permettant d'assurer la non dégradation du produit dans le temps. De manière remarquable et similaire aux observations des exemples précédents, un produit équivalent stable (préparé sans traitement par vibration haute fréquence) ne peut pas être obtenu sans ajout de tensioactif. De plus, un produit préparé avec le même protocole mais contenant en plus un tensioactif aura une efficacité moindre. Both ingredients are emulsified under high frequency vibration, as described in patent application WO2010 / 149668. The pH of the preparation is then adjusted to 7, if necessary. A texturizer may optionally be added to the emulsion so as to obtain a texture that is less liquid and easier to apply. It is also possible to add to this formula, without modifying the properties of interest, a preservative and an antioxidant in respective proportions to ensure the non-degradation of the product over time. Remarkably and similar to the observations of the previous examples, a stable equivalent product (prepared without high frequency vibration processing) can not be obtained without the addition of surfactant. In addition, a product prepared with the same protocol but containing in addition a surfactant will be less effective.
Le produit selon l'invention peut être utilisé directement pour des applications classiques de l'huile essentielle d'arbre à thé (maux de gorge, acné, antiseptique, etc.). En usage topique, il ne nécessite pas de dilution supplémentaire. En particulier, aucune dilution dans une huile n'est nécessaire. Le touché du produit est totalement aqueux et son application ne laisse donc aucune sensation désagréable de collant et de gras. The product according to the invention can be used directly for conventional applications of tea tree essential oil (sore throat, acne, antiseptic, etc.). In topical use, it does not require additional dilution. In particular, no dilution in an oil is necessary. The touch of the product is completely aqueous and its application therefore leaves no unpleasant feeling of stickiness and fat.

Claims

REVENDICATIONS
1 . Composition de type émulsion huile-dans-eau comprenant une solution aqueuse et au moins une huile essentielle, caractérisée en ce que cette composition ne contient pas de tensioactif et qu'elle est obtenue par un traitement ultrasonore dont la fréquence de vibration est supérieure ou égale à 1 MHz. 1. Oil-in-water emulsion type composition comprising an aqueous solution and at least one essential oil, characterized in that this composition contains no surfactant and is obtained by an ultrasonic treatment whose vibration frequency is greater than or equal to at 1 MHz.
2. Composition selon la revendication 1 , dans laquelle ladite solution aqueuse est un hydrolat, une infusion de plante ou une eau de fruits. 2. Composition according to claim 1, wherein said aqueous solution is a hydrosol, a plant infusion or a fruit water.
3. Composition selon la revendication 2, dans laquelle l'hydrolat et l'huile essentielle sont issus de la même plante. 3. Composition according to claim 2, wherein the hydrosol and the essential oil are from the same plant.
4. Composition selon l'une des revendications précédentes, comprenant en outre un agent gélifiant. 4. Composition according to one of the preceding claims, further comprising a gelling agent.
5. Composition selon l'une des revendications précédentes dans laquelle la solution aqueuse est de l'eau et les huiles essentielles sont un mélange d'HE de katafray, de romarin à camphre, d'eucalyptus citronné et de genévrier commun. 5. Composition according to one of the preceding claims wherein the aqueous solution is water and the essential oils are a mixture of katafray HE, camphor rosemary, lemon eucalyptus and common juniper.
6. Utilisation d'une composition selon la revendication 5 pour échauffer les muscles avant l'effort. 6. Use of a composition according to claim 5 for heating the muscles before exercise.
7. Composition selon l'une des revendications 1 à 4 comprenant entre 1 et 2,5 % d'huile essentielle et un hydrolat. 7. Composition according to one of claims 1 to 4 comprising between 1 and 2.5% of essential oil and a hydrosol.
8. Composition selon l'une des revendications 1 à 4 ou 7 comprenant de l'huile essentielle de menthe poivrée et un hydrolat de menthe poivrée. 8. Composition according to one of claims 1 to 4 or 7 comprising peppermint essential oil and a peppermint hydrosol.
9. Composition selon l'une des revendications 1 à 4 ou 7 comprenant de l'huile essentielle de lavande et un hydrolat de lavande. 9. Composition according to one of claims 1 to 4 or 7 comprising lavender essential oil and a lavender hydrosol.
10. Composition selon l'une des revendications 1 à 4 ou 7 comprenant de l'huile essentielle d'arbre à thé et un hydrolat d'arbre à thé. 10. Composition according to one of claims 1 to 4 or 7 comprising tea tree essential oil and a tea tree hydrosol.
EP18796739.3A 2017-10-16 2018-10-16 Oil-in-water emulsion based on essential oils, and formulated without surfactant Withdrawn EP3697371A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1771085A FR3072280A1 (en) 2017-10-16 2017-10-16 OIL-IN-WATER EMULSION BASED ON ESSENTIAL OILS AND FORMULATED WITHOUT SURFACTANTS
FR1853190A FR3072290B1 (en) 2017-10-16 2018-04-12 OIL-IN-WATER EMULSION BASED ON ESSENTIAL OILS AND FORMULATED WITHOUT TENSIO-ACTIVE
PCT/FR2018/052569 WO2019077258A1 (en) 2017-10-16 2018-10-16 Oil-in-water emulsion based on essential oils, and formulated without surfactant

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FR3098732B1 (en) * 2019-07-15 2022-08-12 Genialis METHOD FOR IMPROVING THE BIOAVAILABILITY OF HYDROPHILIC COMPOUNDS IN AN AQUEOUS SOLUTION
FR3118869A1 (en) * 2021-01-20 2022-07-22 Genialis METHOD FOR IMPROVING THE ANTIOXIDANT ACTIVITY OF VITAMIN C IN AQUEOUS SOLUTION

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FR1322103A (en) * 1958-03-27 1963-03-29 Process for the production of stable emulsions and emulsions thus obtained
FR2720644B1 (en) 1994-06-06 1996-07-05 Oreal Water-in-oil emulsion without surfactant.
FR2722116B1 (en) 1994-07-11 1996-08-23 Oreal OIL-IN-WATER EMULSION WITHOUT SURFACTANT, STABILIZED BY HOLLOW THERMOPLASTIC PARTICLES
FR2750327B1 (en) 1996-06-28 1998-08-14 Oreal COMPOSITION FOR TOPICAL USE IN THE FORM OF OIL-IN-WATER EMULSION WITHOUT SURFACTANT CONTAINING A POLY (2-ACRYLAMIDO 2-METHYLPROPANE SULFONIC) CROSSLINKED AND NEUTRALIZED
DE19733625A1 (en) 1997-07-28 1999-02-04 Lancaster Group Gmbh Decorative cosmetic O / W emulsion
FR2771293A1 (en) 1997-11-24 1999-05-28 Fabre Pierre Dermo Cosmetique Dermo-cosmetic water in oil emulsion without surfactant, useful for sun protection products
FR2799965B1 (en) 1999-10-22 2002-10-31 Oreal EMULSION-FREE EMULSIONS CONTAINING AT LEAST ONE INSOLUBLE ORGANIC UV FILTER
FR2947186B1 (en) * 2009-06-24 2016-01-01 Sas Genialis PROCESS FOR PREPARING STABLE OIL-IN-WATER EMULSION
FR2973706B1 (en) * 2011-04-06 2016-05-20 Guyen Gerard Duc N ESSENTIAL PHYTO-CONCENTRATE COMPOSITION ANTISPASMODIC DISCOVERY AND MUSCLE COMFORT
FR2988999B1 (en) * 2012-04-05 2014-05-02 Oreal COSMETIC COMPOSITION COMPRISING A PARTICULAR ESSENTIAL OIL AND AN ESTER OF AMINO ACID AND FATTY ALCOHOL
CN103876963A (en) * 2012-12-22 2014-06-25 赵建英 Mild soft moist makeup-removing lotion
EP3209283A1 (en) * 2014-10-21 2017-08-30 Universita' Degli Studi Di Pavia Oil-in-water nanoemulsions
US10688069B2 (en) * 2016-03-31 2020-06-23 REV Pharmaceuticals LLC Sports health performance composition

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FR3072290B1 (en) 2020-10-09
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FR3072290A1 (en) 2019-04-19

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