EP3681462A1

EP3681462A1 - Oil solution of benzyl alcohol, and use in the prevention and treatment of parasitoses

Info

Publication number: EP3681462A1
Application number: EP18782315.8A
Authority: EP
Inventors: Nadine Pagnotta
Original assignee: Invictus
Current assignee: Invictus
Priority date: 2017-09-14
Filing date: 2018-09-13
Publication date: 2020-07-22
Also published as: FR3070865A1; WO2019053134A1; UA127055C2

Abstract

The invention relates to a composition in the form of an oil solution which consists, at least, of an oil dispersion phase with benzyl alcohol dispersed therein, and to the use thereof in topical application to the skin, cutaneous appendages, fur, mucous membranes or scalp, in the prevention and treatment of parasitoses in humans or animals.

Description

OIL SOLUTION OF BENZYL ALCOHOL AND USE IN THE PREVENTION AND

TREATMENT OF PARASITOSES

The present invention relates to the prevention and treatment of parasitosis, in particular the fight against head lice, nits, fleas, demodex, chiggers and scabies. The invention relates in particular to a particular oily solution very effective in the fight against these parasites.

Parasitic diseases are a real public health problem that can affect everyone. Often non-serious for health, external parasites can nevertheless be very disabling for humans or animals that are affected. This is particularly the case with fleas, demodex, gall, chiggers and lice.

The demodex is a genus of mites of the family Demodicidae. Some species are naturally part of the microflora of human skin or live associated with hair, eyelashes and / or eyebrows. They live in or near the hair follicles of mammals. Although the presence of Demodex is generally benign, it can cause some skin diseases. The researchers explain that Demodex accumulate waste throughout their lives in their abdomen. This waste, which they release at their death, can cause, if the mites are very numerous, redness and inflammation of the skin, eyelids and eyelashes. This disease affects between 5 and 20% of the population. Current treatments involve the application of mercury salt cream increasingly proscribed by health authorities or by corticosteroid preparations to relieve inflammation but no effect on the parasite. There is therefore a need for safe and effective new treatment against this parasitosis acting physically by stifling these parasites.

Fleas form the order of the siphonaptera (Siphonaptera, from the Latin sipho "tube"), formerly called Aphaniptera (Aphaniptera). They are holometabolic pterygotic insects, characterized by, among other things, their mouthparts shaped like a piercing-sucking apparatus. They are ectoparasites: current fleas infest mammals (of which the man) and some birds, and live from the blood of their bearers. As it passes easily from one animal to another, it can carry various animal diseases, human or zoonotic. They are also a possible source of allergies.

Current treatments use insecticidal shampoos such as organophosphorus compounds such as malathion, permethrins or pyrethrins, combined with a synergistic agent such as piperonyl butoxide, fipronil.

However, these are products that are considered toxic and polluting the environment. Some of them, including fipronil, cause behavioral problems in pets.

Scabies (gall, "gall", or scabies, "scabies") is an infectious skin disease caused by a microscopic mite-like parasite (Sarcoptes scabiei). According to the subtype of this parasite, human scabies, specific for humans, and specific scales of other mammals are distinguished. It is a benign contagious disease, which is transmitted by contact and whose main symptom in humans is itching. The lesional profile is that of perivascular dermatitis. Depending on the case, the diagnosis may be made on clinical examination or may require a sample. The treatment uses drugs used orally or cutaneously.

These treatments are based on pharmacologically active molecules and not devoid of side effects which demonstrates the interest of a treatment acting physically on the parasite. The reference product is ivermectin administered orally, which can cause side effects, particularly neurotoxic effects.

The chickens designate the larvae of a species of small mite of the Trombiculidae family: Trombicula autumnalis, also called red mullet, harvest or pickle.

The larva of this arthropod mite temporarily parasitizes the warm-blooded organisms and causes by its bites itching sometimes important in its host.

It is a vector of several diseases, and many wild or domestic animal species, including the cat, the dog, the rabbit, the cow and the horse, seem to be able to serve as a reservoir for this parasite.

The itching (on the man) can be calmed by taking an antihistamine, the need for a topical steroid is more rare and possibly an antibiotic cream in case of risk of superinfection. If dogs and cats or other domestic animals are affected, they must also be treated (the veterinarian prescribes, for example, a fipronil-based anti-parasite (0.25%), an oral antihistamine and a local pyrethrum treatment). , permethrin or phosphoric ester). However, these are products that are considered toxic and polluting the environment. Some of them, including fipronil, cause behavioral problems in pets.

There is therefore also a need for products capable of acting physically on scarpotes, chiggers and fleas and without any adverse effects for both the treated subjects and the environment.

Lice are hematophagous insects that can be responsible for frequent and contagious parasitic diseases called pediculosis or phitiriasis. Three types of lice in particular are responsible for these ectoparasitoses:

- Pediculus humanus corporis, the body louse, living in the seams and folds of clothing, passing on the skin only for food, responsible for body pediculosis,

- Phtirius pubis, pubic louse and other areas of the body covered with coarse hairs or tinea, responsible for pubic phitiriasis, and

- Pediculus humanus capitis: the head lice, responsible for pediculosis of the scalp and pediculosis of the head.

The pediculosis of the head is the most widespread. It is a very common endemic condition affecting all countries and all socio-economic backgrounds. It mainly affects children between 5 and 11 years old.

The head louse is a small greyish-colored insect that feeds on the host's blood three to five times a day. Their eggs or nits, oval shaped, attach themselves very securely to the hair thanks to the sticky material spumaline secreted by the nits. Each slow is usually glued to a hair, mostly close to the skin.

Head lice can not jump or fly and are mostly transmitted by face-to-face contact. They may be present for several months on the scalp without the wearer noticing it, which hampers the implementation of adequate prophylactic measures and promotes transmission. The infestation is usually symptomless for the first three to four weeks, and then itching usually occurs due to the presence of allergenic substances in the saliva of the parasites.

In the treatment of pediculosis of the head several approaches can be used. It is particularly possible to comb the hair to eliminate lice that die quickly once they are separated from their host, but this solution eliminates only part of the lice and can not be used alone, except for children at a very young age.

The most common approach is to apply an insecticide to the scalp.

The first local treatments that have been developed are insecticide-based products, such as organophosphorus compounds such as malathion, permethrins or pyrethrins, combined with a synergistic agent such as piperonyl butoxide. These treatments, particularly those based on malathion, were considered effective. However, these are very irritating products for the scalp, which also have a strong unpleasant odor and are considered toxic and polluting the environment. In addition their effectiveness decreases with time due to an enzymatic adaptation, so that this type of product is neglected.

There are also local treatments based on siloxanes including dimeticone-based, such as those described in the application WO-01/19190. These products act by drowning the lice in an oily phase, which die by asphyxiation.

Nevertheless, these products are not sufficiently effective especially against nits and require several repeated applications. In addition they make the hair greasy, and are very flammable.

In addition, the silicones used are not biodegradable, which is harmful for the environment.

Insecticidal products based on siloxanes and fatty acid esters, such as those described in patent application EP-1,499,184, are also known. These products work by dissolving the chitin that covers the exoskeleton of the louse, causing it to dehydrate and then die. They are known under the trade name ^® Resultz constituted 50% by the Cyclomethicone, highly flammable, and 50% of isopropyl myristate.

Nevertheless, their effectiveness on adult lice is very variable and their power on nits has not been established. In addition, these products can not be applied in children of less than 4 years and their use is tedious since it requires an application on dry hair, a time of exposure of at least 8 hours and several hair shampoos and scalp to be eliminated and reduce the fat side of the hair. A new application, or two additional applications are needed to eliminate nits that are hatched after an interval of 7 days.

These products also make the hair greasy and flammable.

There are also formulations of the microemulsion type described in the application FR0955753, however these formulations are totally effective on lice after a time of one hour which is long compared to current consumer demands and efficiency on slow is not complete.

The object of the invention is to overcome the drawbacks of the prior art, by proposing an easy-to-use solution, inexpensive, without toxic insecticide, non-flammable very effective both against head lice, nits, fleas, chiggers, scarpotes and demodex and also exhibiting preventive properties by exerting a repulsive power.

In order to meet them, the invention proposes an oily solution constituted at least by an oily dispersing phase in which benzyl alcohol is dispersed.

Benzyl alcohol is particularly known for its use as a versatile solvent in the manufacture of inks, paints, lacquers, and epoxy coatings. It is also a precursor of several esters, used in photography (as developer), in the manufacture of soaps, perfumes and as a flavoring agent.

Benzyl alcohol, at low concentration (about 1%), is also used as a preservative to prevent microbial growth of therapeutic or cosmetic formulations.

In addition, the use of benzyl alcohol in 5% aqueous solution for the control of lice in children over 6 months and adults has already been described. This is the case in particular of patent US 6793931 which describes aqueous formulations based on benzyl alcohol. However, these formulations, sold inter alia under the name of Ulfesia ^® in the United States, are not effective on nits and a second application is necessary. In addition, benzyl alcohol is poorly soluble in water (solubility at 40 g / L at 20 ° C) which means that existing formulations are emulsions whose stability over time is restricted and whose manufacturing process is complex. Advantageously, the present invention proposes the use of benzyl alcohol dispersed in an oil, which avoids all these problems and makes it possible to obtain a very important efficacy pediculicide, lenticide and reinforced repellent, in a single application with great ease of use. especially for children. The composition according to the invention is also effective against fleas, demodex, chiggers and scabies.

The subject of the invention is therefore also the use of an oily solution consisting at least of an oily dispersing phase in which benzyl alcohol is dispersed, for topical application to the skin, superficial body growths, mucous membranes or scalp. , in the prevention and treatment of parasitosis in humans or animals.

The invention is now described in detail.

DEFINITIONS

In the present application, the singular form of a word may include the plural, and vice versa, unless the context indicates otherwise. Thus, the references "a", "an", and "the", "the" include the plural of these terms. For example, the reference to "a solution" or "a composition" includes a plurality of such "solutions" or "compositions".

By "colloidal particles" in the sense of the invention means suspended particles whose size is between one nanometer (10-9 m) and ten micrometers. For the purposes of the invention, the term "oily dispersing phase" or "oil" or "oily component" or "oily phase" means an oil in which at least one molecule is dispersed.

For the purposes of the invention, the term "rinse" means the action of rinsing the composition according to the invention present on the hair or the skin without having to add an additional soap or shampoo in addition to the composition.

DETAILED DESCRIPTION OF THE INVENTION

The subject of the invention is therefore a composition in the form of an oily solution constituted at least by an oily dispersing phase in which benzyl alcohol is dispersed.

The oily dispersing phase preferably represents between 5 and 95.5% by weight relative to the total weight of the composition. The benzyl alcohol in the composition is preferably present at least 0.5% by weight relative to the total weight of the composition, in particular at least 1%. Even more preferentially, it is between 0.5 and 20% by weight relative to the total weight of the composition, in particular between 1 and 20%.

The oily dispersing phase may be any oil suitable for use on the skin and scalp. In particular, the oily dispersant phase may be composed of isopropyl myristate and / or a mixture of glycerides of polyethylene glycol esters and / or one or more caprylocapous triglyceride (s) and / or one or more silicone (s) and / or one or more vegetable oil (s) such as olive oil and / or one or more mineral oils such as paraffin.

The particular form of the oily solution, combined with the action of benzyl alcohol, makes it possible to drown and asphyxiate the parasites, in particular the lice and the nits. In addition, certain oils, such as isopropyl myristate and benzyl alcohol are able to dissolve the chitin of the exoskeleton parasites (lice, fleas, demodex) and nits, which further enhances the effectiveness of the composition.

The composition according to the invention, in addition to the oily dispersing phase and benzyl alcohol, may also contain less surfactant also called surfactant. The presence of the surfactant makes it possible to reduce the surface tension of the medium, which facilitates the penetration of the formulation into the parasites, in particular lice and nits, thus contributing to reinforcing the effectiveness of the composition. In addition, it facilitates the rinsability of the composition according to the invention.

Indeed, the composition according to the invention is preferably rinsable and the presence of one or more agent (s) surfactant (s) improves the rinsing step of the composition after application. Thus, the rinsable nature of the composition according to the invention facilitates its use, in particular on the scalp or the fur of animals, the treatment can be carried out in a single step without the need to apply additional shampoo.

The agent (s) surfactant (s) present in the composition according to the invention may be chosen from anionic surfactants, cationic surfactants, amphoteric surfactants and nonionic surfactants. It may be in particular one or more of the following surfactant (s): carboxylates, sulfuric esters of primary alcohols, sulfonates, cetrimide bromide, lecithin, esters of polyol fatty acids, sucrose esters, polyoxyethylenated fatty acid esters, sorbitan esters, polyoxyethylenesorbitan esters, polyoxyethylenated fatty acid esters, poloxamers, polyethylene glycol ester mixtures and glycerides.

Preferably the composition comprises as surfactant a mixture of polyethylene glycol esters and glycerides such as PEG-8 caprylic / capric GLYCERIDES (Labrasol ^®) or propylene glycol LAURATE (Lauroglycol ^®) alone or in combination.

Advantageously, these surfactants are liquid, very fluid, and weakly or non-irritating. The surfactants present in the compositions according to the invention are between 10 and 50% by weight relative to the total weight of the composition.

According to a particular embodiment of the invention, the composition comprises:

Between 0.5 and 20%, especially between 1 and 20% of benzyl alcohol,

Between 10 and 50% surfactant (s), and

Between 5 and 60% oily dispersant phase.

The composition according to the invention may also comprise colloidal particles. Preferably, the colloidal particles present in the composition according to the invention have a diameter of between 5 and 100 nm.

They may consist of particles of alumina silicon dioxide, clays, silica beads, glass beads, iron oxide, iron silicate, magnesium silicate or titanium dioxide. , alone or in mixtures.

The colloidal particles when they are present in the composition according to the invention are preferably in a proportion of 0.1 to 20% by weight relative to the total weight of the composition, in particular between 0.1 and 5%.

Advantageously, the colloidal particles further improve the effectiveness of the composition according to the invention, in particular against nits and lice. They agglomerate at the level of spiracles, breathing holes of the nits thus causing their asphyxiation.

If they are silica particles, because of their negative charge, they have a particular affinity for the components of the chitin of the insects which is positively charged, which explains the particular tropism of the silica particles for the shell of the parasites. The chitin of the carapace of arthropods and thus lice and nits is a polymer of N-acetylglucosamine which has positive charges due to the presence of the amine function. Negatively charged silica particles bind electrostatically to the chitin of arthropods and thus lice and nits obstruct parasite spiracles preventing their breathing thus causing their death. The obstruction of the spiracles of the lice and the nits also inhibits the excretion of the water of the parasites creating an osmotic shock favorable to their death.

The composition according to the invention may also comprise at least one antioxidant agent such as butylhydroxytoluene, butylhydroxyanisol or ascorbyl palmitate, and / or one or more pediculicidal compounds such as malathion, permethrines and pediculicidal or repulsive plant essences. These species can be, for example, aniseed oil, tea tree oil, myrtle oil, lavender oil, neem oil and substances described as growth inhibitors. nits such as Farnesol and Nerolidol. It is also possible to incorporate substances that are repellent for lice, such as myrtle oil, citronella, ethyl butylacetylaminopropionate (IR 3535), DET (diethyltoluamide), lemon essential oils. , lavender, rose geranium, rosemary cineole, tea-tree, celery essential oil.

The viscosity of the solution can be adapted to correspond to different forms of application and galenic presentations.

Without gelling agent the solution may in particular be applied in the form of a lotion or spray. Its viscosity is preferably between 1.00 ^χ 10 ^{~ 3} and 1.0 mPa.s. (Brookfield LVT viscometer, Cylinder 3, Speed 12 at 20 ° C).

In the presence of gelling agent the viscosity can reach a gel texture that extends like a styling gel and does not flow into the eyes. In this case, the viscosity is preferably between 1.0 and 100 mPa.s. (Brookfield LVT viscometer, Cylinder 3, Speed 12 at 20 ° C). Furthermore, the oil solution of the invention can be gelled, for example by adding siloxane copolymer type components and / or polyamides, such as those sold by the company Croda under the trade name LP20 Oléocraft ^®.

According to a particular embodiment of the invention, the oily solution consists of:

between 0.1 and 15% by weight of benzyl alcohol

Between 0.1 and 15% by weight of colloidal particles, in particular of colloidal silica,

between 10 and 50% by weight of surfactants,

between 5 and 60% by weight of an oily dispersing phase, between 1 and 15% by weight of siloxane and polyamide copolymer for thickening the formulation.

Advantageously, the composition according to the invention is stable, transparent, washable with water and very little or no irritant. It is very effective against both head lice, especially head lice, and against nits. It also acts faster than the products of the prior art.

In addition, the composition according to the invention does not require the addition of a complementary preservative, benzyl alcohol also plays this role.

The oily solution according to the invention can be obtained by carrying out a process comprising the following steps, preferably at ambient temperature:

preparation of the oily dispersing phase containing the benzyl alcohol by mixing at least one oily component with benzyl alcohol,

- optionally solubilization of the surfactant (s) in the oily phase,

optionally adding at least one antioxidant to the oily phase,

- optionally dispersion of the colloidal particles in the oily phase.

In the case where it is desired to gel the preparation, the process may also comprise a further step, preferably after the other steps, which consists in heating the oily solution to about 50 ° C. and dispersing a gelling agent such as a polysiloxane copolymer and of polyamide, then to cool the preparation.

The composition according to the invention may be in different galenical forms such as a lotion, a gel or a shampoo. It may also be incorporated into another composition, in particular in the form of a lotion, gel, shampoo or hair mousse intended to be applied to the scalp and human hair or to the coat of animals. Thus, the subject of the invention is also a composition in the form of a lotion, a gel, a shampoo or a hair mousse intended to be applied to the scalp and human hair or to the animal's coat, comprising an oily solution according to the invention.

The compositions according to the invention alone or incorporated in lotions, gels, shampoos, foams, etc. can be applied to human skin, scalp and human hair, but also to animal fur, especially domestic animals. These include horses, donkeys, poultry, cats, dogs, etc. Advantageously, the oily solutions according to the invention or the compositions containing them may be applied to hair (or hair), dry or moist. They are rinsable with water. Thus, the invention makes it possible to combine within the same formulation a pediculicidal product when an infestation is diagnosed by applying the product to dry hair, and a preventive repellent product when an infestation is declared in the environment of the subjects in question. applying in this case the product on wet hair and using shampoo.

One method of application is to impregnate the dry hair with an oily solution and rinse the hair simply with water between five minutes and one hour after application.

It is not necessary to repeat the application after 7 days given the remarkable effectiveness of the preparation on the slow ones.

One of the properties of the present invention is to leave a silky hair combable and aesthetically perfect unlike competing products that leave hair rough, greasy and difficult to style.

The compositions according to the invention have a high dissolution capacity especially vis-à-vis the spumaline, natural glue and strong secreted by the nits that makes it difficult to unhook. Thus the application of the formulations allows easy removal of the nits with the aid of a suitable comb which is an additional advantage over other anti-lice products that make the hair rough and poorly combable.

The invention therefore also relates to a composition according to the invention (or any composition including it) for use in topical application to the skin, superficial body growths, mucous membranes, fur or scalp, in the prevention and control of treatment of parasitosis in humans or animals. In particular the invention relates to the use of the composition in the treatment of pediculosis of the head (control and prevention against head lice and nits), but also for the prevention and treatment of demodex, gall and parasitic diseases caused by fleas and chiggers.

The invention is now illustrated by examples of compositions according to the invention and by particularly comparative tests with a product in the form of emulsified aqueous solution based on benzyl alcohol known under the name of Ulesfia ^® . EXAMPLES

Several examples of compositions according to the invention are presented in the tables below.

Table 1: Examples of compositions according to the invention.

Al A2 A3 formulations are gelled and contain Oléocraft LP20.

A4 A5 A6 formulations are liquid.

Al A2 A3 A5 A6 formulations contain colloidal silica.

Table 2: Examples of compositions according to the invention.

The formulations BIL B2 B3 are gelled and contain Oleocraft LP20. The formulations B4 B5 B6 are liquid.

Formulations B1 B2 B4 B5 B6 contain colloidal silica.

Table 3: Examples of compositions according to the invention.

G 1 G 2 G 3 formulations are gelled and contain Oleocraft LP20.

LI L2 L3 formulations are liquid.

Gl G2 L1 L2 formulations contain colloidal silica.

Gl G3 L1 L3 formulations contain 1% benzyl alcohol.

G2 L2 formulations contain 5% benzyl alcohol.

These formulations are stable, easily rinsable and their manufacturing process are simple and compatible with the usual industrial equipment.

The compositions are obtained by the implementation of the following process:

Fill the main tank with the desired quantity of benzyl alcohol, Gradually add the oily phase with slow and non-turbulent stirring, Add the liquid surfactants with the same stirring parameters, - In the case where the surfactants are waxy, raise slightly the temperature of the tank (40 ° C) and wait for their complete dissolution,

In the case of gelled formulations, dissolve Oléocraft pellets in the tank, Disperse the colloidal silica with more vigorous stirring, and:

• in the case of liquid formulations:

Pack in conventional vials or with spray systems · in the case of gelled formulations:

Proceed with the conditioning steps preferably at a temperature above 25 ° C

The pediculicidal performances of these formulations have been tested below.

TESTS: EVALUATION OF THE EFFICACY PEDICULICIDE AND LENTICIDE OF THE INVENTION

The tests were carried out in order to evaluate the effectiveness of the compositions of the examples of Table 3: Gl G2 G3 L1 L2 L3 against a distilled water control in comparison with the Ulsefia ^® Product.

Effectiveness on lice

The objective is to evaluate the pediculicidal efficacy of Gl G2 G3 L1 L3 L3 samples against a distilled water control and in comparison with the Ulsefia ^® product.

To perform the efficacy tests, the operating protocol is described in the following.

Lots of hundreds of lice are:

- placed in the lid of a petri dish 5.5 cm in diameter,

- transferred into the bottom of the petri dish lined with a filter paper disk, - submerged by 300μΙ of distilled water, or 300 μΙ examples Gl G2 G3 Ll L2 L3, and 300 μΙ Product Ulsefia ^® in using a micropipette,

- and finally placed, open box, in a larger box parallelepiped of 5.5 x 7 cm half open.

The whole is left at room temperature. The condition of the lice is then observed with immediate effect (up to about 2 minutes), 5 minutes, 15 minutes, 30 minutes, 1, 3, 6 and 12 hours. At each observation, dead lice are noted and then counted; The average of the results obtained with each sample (distilled water, Gl G2 products G3 Ll L2 L3, the Ulsefia ^® Product, are presented in the following table.

The results expressed as percentage of dead lice observed at different time periods are presented in Table 2.

Table 4 - Mortality of lice expressed as a percentage according to the time of exposure to different products

These results show that the product Ulesfia ^® , aqueous emulsion of benzyl alcohol reaches 100% mortality after one hour of application.

It is found that all the formulations of the present invention act more rapidly as early as the first five minutes.

What is particularly remarkable are the performances of formulations G1 and L1 which contain concentrations of benzyl alcohol of 1% and which have efficiencies comparable to G2 and L2 formulations which are dosed at 5% of benzyl alcohol, which clearly demonstrates the surprising nature of the present invention

Gl G2 L1 L2 formulations which contain colloidal particles have also been found to have improved performances compared with formulations G3 and L3 which do not contain them.

Efficiency on nits

A 1.5 cm square of fabric carrying a hundred nits is placed in the lid of a petri dish (5.5 cm in diameter). 300 μl of distilled water or Gl G2 G3 L1 L3 L3 products, the Ulsefia ^® product, are poured onto the nits so that they are completely covered and the poured compositions diffuse rapidly on the nerve-bearing tissue.

The tissue squares and their nits are then placed on a washer of filter paper, moistened with ΙΟΟμΙ of distilled water, lining the bottom of the petri dish.

The petri dishes are placed in an oven at 28 ° C and 60% relative humidity for 5 and 15 minutes, then washed and rinsed with distilled water before being deposited on a new filter paper washer.

Petri dishes are placed in an oven at 28 ° C and 60% relative humidity for a fortnight (until hatching nits).

Nits are observed from the ^6th day until I5 ^th day to note outbreaks and accounted for. Whenever possible, the hatched lice are recovered and fed.

The results obtained expressed as a percentage of slow dead are presented in the following Table 5.

Table 5 - Nitrogen mortality expressed as a percentage after a 5 and 15 minute exposure time

These results show that the Ulesfia ^® product in the form of an emulsion dosed with 5% of benzyl alcohol has a low lenticidal activity even after a contact time of 15 minutes.

On the other hand, the products of the present invention show a remarkable activity for all the formulations G1 G2 G3 L1 L2 L3.

Surprisingly, the formula containing 1% of benzyl alcohol (G1 G3 L1 L3) has an activity equivalent to the formulations which contain 5% (G2 & L2)

Such efficacy has never been described in the prior art for benzyl alcohol preparations for slow ones particularly resistant to pediculicidal treatment in general. As is the case for lice, formulations containing colloidal particles have an even better efficiency (Gl G2 L1 L2) compared to formulations that are free of them (G3 and L3).

Claims

1. Composition in the form of an oily solution consisting at least of an oily dispersing phase in which is dispersed benzyl alcohol.

2. Composition according to claim 1, characterized in that it comprises at least 0.5% benzyl alcohol by weight relative to the total weight of the composition.

3. Composition according to one of the preceding claims, characterized in that it comprises between 0.5 and 20% of benzyl alcohol by weight relative to the total weight of the composition.

4. Composition according to one of the preceding claims, characterized in that the oily dispersant phase is composed of isopropyl myristate and / or a mixture of glycerides of polyethylene glycol esters and / or one or more triglyceride (s) caprylocaprique (s) and / or one or more silicone (s) and / or one or more vegetable oil (s).

5. Composition according to one of the preceding claims, characterized in that it also comprises at least one surfactant.

6. Composition according to the preceding claim, characterized in that the agent (s) surfactant (s) are selected (s) from anionic surfactants, cationic surfactants, amphoteric surfactants and nonionic surfactants.

7. Composition according to one of claims 5 or 6, characterized in that the agent (s) surfactant (s) are selected (s) from carboxylates, sulfuric esters of primary alcohols, sulfonates, bromide cetrimide, lecithin, polyol fatty acid esters, sucrose esters, polyoxyethylenated fatty acid esters, sorbitan esters, polyoxyethylenated sorbitan esters, polyoxyethylenated fatty acid esters, poloxamers, mixtures of polyethylene glycol esters and glycerides.

8. Composition according to one of claims 5 to 7, characterized in that it comprises between 10 and 50% agent (s) surfactant (s) by weight relative to the total weight of the composition.

9. Composition according to one of the preceding claims, characterized in that it also comprises colloidal particles with a diameter of between 5 and 100 nm.

10. Composition according to the preceding claim, characterized in that the colloidal particles consist of particles of silicon dioxide of alumina, clays, silica beads, glass beads, iron oxide, iron silicate, magnesium silicate, titanium dioxide, alone or in mixtures.

11. Composition according to one of claims 9 or 10, characterized in that it comprises between 0.1 and 20% of colloidal particles by weight relative to the total weight of the composition.

12. Composition according to one of the preceding claims, characterized in that it also comprises at least one antioxidant agent.

13. Composition according to one of the preceding claims, characterized in that it also comprises one or more pediculicidal compounds (s).

14. A composition according to claim 13, characterized in that the agent (s) pediculicide (s) are selected (s) from malathion, permethrines and pediculicidal or repellent vegetable essences.

15. Composition according to one of the preceding claims, characterized in that the oily dispersant phase is between 5 and 95.5% by weight relative to the total weight of the composition.

16. Composition in the form of lotion, gel, shampoo or hair mousse intended to be applied to the scalp and human hair or on animal hair, comprising a composition according to one of the preceding claims.

17. Composition according to one of the preceding claims for use in topical application to the skin, superficial body growth, peeling, mucous membranes or scalp, in the prevention and treatment of parasitosis in humans or animals. .

18. Composition for its use according to claim 17 for the prevention and treatment of pediculosis of the head.

19. A composition for its use according to claim 17 for the prevention and treatment of demodex, scab or parasitosis caused by fleas or chiggers.