EP3634883B1 - Dosierventil und fluidproduktabgabevorrichtung mit solch einem ventil - Google Patents

Dosierventil und fluidproduktabgabevorrichtung mit solch einem ventil Download PDF

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Publication number
EP3634883B1
EP3634883B1 EP18735630.8A EP18735630A EP3634883B1 EP 3634883 B1 EP3634883 B1 EP 3634883B1 EP 18735630 A EP18735630 A EP 18735630A EP 3634883 B1 EP3634883 B1 EP 3634883B1
Authority
EP
European Patent Office
Prior art keywords
valve
diameter
metering
inlet channel
radial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP18735630.8A
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English (en)
French (fr)
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EP3634883A1 (de
Inventor
Ludovic Petit
Ségolène SARRAILH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aptar France SAS
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Aptar France SAS
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Filing date
Publication date
Application filed by Aptar France SAS filed Critical Aptar France SAS
Publication of EP3634883A1 publication Critical patent/EP3634883A1/de
Application granted granted Critical
Publication of EP3634883B1 publication Critical patent/EP3634883B1/de
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
    • B65D83/44—Valves specially adapted therefor; Regulating devices
    • B65D83/52—Valves specially adapted therefor; Regulating devices for metering
    • B65D83/54—Metering valves ; Metering valve assemblies
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B12/00—Arrangements for controlling delivery; Arrangements for controlling the spray area
    • B05B12/02—Arrangements for controlling delivery; Arrangements for controlling the spray area for controlling time, or sequence, of delivery

Definitions

  • the present invention relates to a metering valve and a fluid dispenser device comprising such a valve.
  • metering valves in which on each actuation of the valve, a precise dose of fluid product is dispensed, are well known in the state of the art, and are generally assembled on a reservoir containing the fluid product and a propellant gas used. to achieve expulsion of the dose.
  • So-called retention valves include a valve which, in the rest position, partially closes the metering chamber. More precisely, the exterior of the valve cooperates in a sealed manner with the chamber seal of the metering chamber, so that the metering chamber is only connected to the reservoir, in this rest position, via the internal channel of the metering chamber. the valve.
  • the metering chambers of the so-called non-priming valves only fill up just before the actual actuation.
  • the filling of the reservoir with the fluid product to be dispensed is generally done after assembly of the metering valve on the reservoir, through said metering valve.
  • An important parameter for a metering valve is the proportion of fine particles distributed with each actuation. Indeed, these fine particles are particularly effective from a therapeutic point of view.
  • Another important parameter is the time for filling the tank through the metering valve, which should not be too long so as not to slow down the manufacturing process.
  • the object of the present invention is to provide a metering valve which does not reproduce the aforementioned drawbacks.
  • the object of the present invention is thus to provide a metering valve which optimizes the proportion of fine particles distributed on each actuation, while guaranteeing an acceptable filling rate through said valve.
  • the object of the present invention is in particular to provide a metering valve which is simple and inexpensive to manufacture and assemble, and which functions reliably.
  • the present invention therefore relates to a metering valve for dispensing fluid product, comprising a valve body containing a metering chamber, and a valve sliding axially in said valve body between a rest position and a dispensing position, for selectively dispensing the contents of said metering chamber, said valve being urged towards its rest position by a spring cooperating on the one hand with said valve body and on the other hand with said valve, said valve comprising a central axial channel provided with an axial outlet orifice and a radial inlet channel which is disposed in said metering chamber when said valve is in the dispensing position, said radial inlet channel comprising, in the direction of dispensing of the fluid product, an opening inlet and an outlet opening opening into said central axial channel, a diameter of said radial inlet channel being between 0.30 and 0.40 mm, advantageously approx. iron 0.35 mm, a diameter of said outlet opening being equal to the diameter of said radial inlet channel and a diameter of said inlet
  • said radial inlet channel is cylindrical over a major part of its length from said outlet opening.
  • the diameter of said inlet opening is between 0.6 and 0.8 mm, advantageously around 0.7 mm.
  • the radial depth of said inlet opening is approximately 0.2 mm.
  • the present invention also relates to a fluid dispenser device comprising a metering valve as defined above fixed to a reservoir.
  • the metering valve shown on figure 1 comprises a valve body 10 extending along a longitudinal central axis. Inside said valve body 10, a valve 30 slides between a rest position, which is that shown in figure. figure 1 , and a dispensing position, shown on the figure 2 , in which the valve 30 is pressed inside the valve body 10.
  • This valve is intended to be assembled on a reservoir 1 (of which only the neck is shown schematically on the figure 1 ), preferably by means of a fixing element 5, which may be a crimp, screw or snap cap, and advantageously with the interposition of a neck seal 6.
  • a ring 4 can be assembled around the valve body 10, in particular to reduce the dead volume in the inverted position and to limit the contact of the fluid product with the neck seal 6.
  • This ring 4 can be of any shape, and the example of the figure 1 is not limiting.
  • the reservoir 1 contains the fluid product and the propellant gas, in particular a formulation consisting of one or more active principle (s) in suspension and / or in solution in a liquefied propellant gas, as well as possibly excipients.
  • the valve 30 is biased towards its rest position by a spring 8, which is arranged in the valve body 10 and which cooperates on the one hand with this valve body 10, and on the other hand with the valve 30, preferably with a radial flange 320 of the valve 30.
  • a metering chamber 20 is defined inside the valve body 10, said valve 30 sliding inside said metering chamber 20 to allow distribution of the contents thereof. ci when the valve is actuated.
  • the metering chamber 20 is preferably defined between two annular seals, a valve seal 21 and a chamber seal 22, in a well known manner.
  • the valve body 10 comprises a cylindrical part 15 in which the spring 8 is disposed and in which the collar 320 slides between its rest and distribution positions. In the position of the figure 1 , this cylindrical part 15 is the lower part of the valve body.
  • This cylindrical part 15 comprises one or more longitudinal openings 11, such as slits, extending laterally in said cylindrical part 15 of the valve body, over a part of the axial height of the valve body in the direction of the central axis. longitudinal. These openings 11 allow the metering chamber 20 to be filled after each actuation, when in the inverted position of use (with the valve placed under the reservoir), the valve 30 returns from its dispensing position to its rest position.
  • the figure 1 represents the valve in the upright storage position, that is to say the position in which the metering chamber 20 is placed above the reservoir.
  • the valve 30 comprises a central axial channel 35 provided with an axial outlet orifice 301 and a radial inlet channel 302 which is disposed in the metering chamber 20 when the valve 30 is in the dispensing position.
  • This radial inlet channel 302 comprises, in the direction of distribution of the fluid product, an inlet opening 3021 and an outlet opening 3022, the latter opening into said central axial channel 35.
  • the graph of the figure 5 illustrates test results that demonstrate this effect.
  • the figure 5 also shows that above 0.40 mm, the change in diameter no longer has an impact on fine particles.
  • the test of figure 5 consisted in evaluating the aerodynamic size of the particles (APSD "Aerodynamic Particle Size Distribution”) coming from a metering valve. This test was carried out with specific equipment called a pharmaceutical impactor, and more precisely the NGI (“Next generation Impactor”, described in the pharmacopoeia under the name of device E). The tests were carried out at a flow rate of 30 liters per minute.
  • the graph of the figure 5 reproduces the sum of fine particles entering the impactor. It is observed that the smaller the diameter of the radial inlet channel 302, the more effective the valve is in terms of the size of the particles expelled during a spray.
  • the values shown in the graph of the figure 5 are quantities of particles fine, that is to say of so-called "small” size. As part of the test figure 5 , these are particles whose aerodynamic diameter is less than 6.4 ⁇ m. It is particularly advantageous that this value is as large as possible, since fine particles of adequate size are particularly effective from a therapeutic point of view.
  • the tests were carried out with a formulation containing a high percentage of ethanol (15% m / m), an excipient, an active principle (salbutamol sulphate) and HFA 134a as propellant.
  • the tanks tested were all filled with the same formulation.
  • the figure 6 is a graph representing the filling times according to the diameter of the radial inlet channel 302.
  • the time indicated is the filling time only, and does not take into account the entire cycle (placing the tank in the machine, lowering the tank). filling head etc.).
  • the purple line represents the typical time for a standard valve, from which it is desirable not to stray too far.
  • the diameter of the radial inlet channel 302 is between 0.30 and 0.40 mm, advantageously about 0.35 mm. This makes it possible to optimize the rate of fine particles distributed, without unacceptably slowing down the filling time of the tank. The therapeutic efficacy of the fluid product dispensed is therefore improved.
  • the radial inlet channel 302 is cylindrical over a major part of its length from said outlet opening 3022 to said inlet opening 3021.
  • the diameter of said outlet opening 3022 is equal to the diameter of said radial inlet channel 302 while the diameter of said inlet opening 3021 is greater than the diameter of said radial inlet channel 302, in particular between 0.6 and 0.8 mm, advantageously about 0.7 mm, while the radial depth of said inlet opening 3021 is advantageously about 0.2 mm.
  • This implementation is advantageous during molding in order to reduce the length of the small diameter pin to achieve radial inlet channel 302, which is fragile.
  • this implementation makes it possible not to have such a fragile pin tangent to the outer circular edge of the valve. This further reinforces the robustness of the molding means and therefore improves the manufacturing reliability of the valve.
  • the valve 30 can be made in two parts, namely an upper part 31 (also called the top of the valve) and a lower part 32 (also called the bottom of the valve).
  • the upper part 31 comprises said central axial channel 35, said axial outlet orifice 301 and said radial inlet channel 302.
  • the lower part 32 is in this embodiment assembled inside the upper part 31.
  • An internal channel 33 is provided in the valve 30, in particular in the lower part 32, which makes it possible to connect the metering chamber 20 to the reservoir 1, to fill said metering chamber 20 when, after each actuation of the valve, the valve 30 returns to its rest position under the effect of the spring 8. This filling takes place when the device is still in the inverted position of use, with the valve placed below the reservoir 1.
  • valve 30 when the valve 30 is in the rest position, the metering chamber 20, outside the valve 30, is substantially isolated from the reservoir 1 by the cooperation between the lower part 32 of the valve 30 and the chamber seal 22 In this rest position, the metering chamber 20 therefore remains connected to the reservoir 1 only via said internal channel 33.
  • the valve shown in the figures. figures 1 and 2 is therefore a retention valve.
  • the invention is however also applicable to other types of valves, in particular valves of the ACT type.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

Claims (5)

  1. Dosierventil zur Abgabe eines Fluidproduktes, umfassend
    einen Ventilkörper (10) mit darin vorgesehener Dosierkammer (20), und
    ein Ventil (30), das zur selektiven Abgabe des Inhalts der Dosierkammer (20) in dem Ventilkörper (10) zwischen einer Ruheposition und einer Abgabeposition axial verschiebbar ist, wobei das Ventil (30) durch eine Feder (8), die einerseits mit dem Ventilkörper (10) und andererseits mit dem Ventil (30) zusammenwirkt, in seine Ruhestellung gedrückt wird, wobei das Ventil (30) einen zentralen axialen Kanal (35) aufweist, der mit einer axialen Austrittsöffnung (301) und einem radialen Eintrittskanal (302) versehen ist, der in der Dosierkammer (20) angeordnet ist, wenn sich das Ventil (30) in der Abgabeposition befindet, der radiale Einlasskanal (302) in der Richtung der Abgabe des Fluidprodukts eine Einlassöffnung (3021) und eine Auslassöffnung (3022) aufweist, die in den zentralen axialen Kanal (35) mündet, wobei ein Durchmesser des radialen Einlasskanals (302) zwischen 0,30 mm und 0,40 mm, vorzugsweise etwa 0,35 mm, beträgt, dadurch gekennzeichnet, dass ein Durchmesser der Auslassöffnung (3022) gleich dem Durchmesser des radialen Einlasskanals (302) ist, und ein Durchmesser der Einlassöffnung (3021) größer als der Durchmesser des radialen Einlasskanals (302) ist.
  2. Ventil nach Anspruch 1, bei dem der radiale Einlasskanal (302) ausgehend von der Auslassöffnung (3022) über einen Großteil seiner Länge hinweg zylindrisch ist.
  3. Ventil nach Anspruch 1 oder 2, bei dem der Durchmesser der Einlassöffnung (3021) zwischen 0,6 mm und 0,8 mm, vorzugsweise etwa 0,7 mm, beträgt.
  4. Ventil nach einem der vorhergehenden Ansprüche, bei dem eine radiale Tiefe der Einlassöffnung (3021) etwa 0,2 mm beträgt.
  5. Vorrichtung zur Abgabe eines Fluidproduktes, dadurch gekennzeichnet, dass die Vorrichtung ein an einem Vorratsbehälter (1) angebrachtes Dosierventil nach einem der vorhergehenden Ansprüche umfasst.
EP18735630.8A 2017-05-05 2018-05-04 Dosierventil und fluidproduktabgabevorrichtung mit solch einem ventil Active EP3634883B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1754009A FR3065891B1 (fr) 2017-05-05 2017-05-05 Valve doseuse et dispositif de distribution de produit fluide comportant une telle valve.
PCT/FR2018/051119 WO2018203013A1 (fr) 2017-05-05 2018-05-04 Valve doseuse et dispositif de distribution de produit fluide comportant une telle valve

Publications (2)

Publication Number Publication Date
EP3634883A1 EP3634883A1 (de) 2020-04-15
EP3634883B1 true EP3634883B1 (de) 2021-07-07

Family

ID=59253766

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18735630.8A Active EP3634883B1 (de) 2017-05-05 2018-05-04 Dosierventil und fluidproduktabgabevorrichtung mit solch einem ventil

Country Status (6)

Country Link
US (1) US10968033B2 (de)
EP (1) EP3634883B1 (de)
JP (1) JP7178364B2 (de)
CN (1) CN110603207A (de)
FR (1) FR3065891B1 (de)
WO (1) WO2018203013A1 (de)

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Also Published As

Publication number Publication date
EP3634883A1 (de) 2020-04-15
JP2020518521A (ja) 2020-06-25
US10968033B2 (en) 2021-04-06
JP7178364B2 (ja) 2022-11-25
FR3065891A1 (fr) 2018-11-09
US20200071062A1 (en) 2020-03-05
FR3065891B1 (fr) 2021-12-24
WO2018203013A1 (fr) 2018-11-08
CN110603207A (zh) 2019-12-20

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