EP3560302A1 - Système de ciblerie à gaz pour production de radio-isotopes - Google Patents
Système de ciblerie à gaz pour production de radio-isotopesInfo
- Publication number
- EP3560302A1 EP3560302A1 EP17828971.6A EP17828971A EP3560302A1 EP 3560302 A1 EP3560302 A1 EP 3560302A1 EP 17828971 A EP17828971 A EP 17828971A EP 3560302 A1 EP3560302 A1 EP 3560302A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- cavity
- support
- window
- flange
- channel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000008685 targeting Effects 0.000 title claims abstract description 30
- 239000002245 particle Substances 0.000 claims abstract description 55
- 238000001816 cooling Methods 0.000 claims abstract description 31
- 239000012809 cooling fluid Substances 0.000 claims description 16
- 238000004519 manufacturing process Methods 0.000 claims description 8
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 claims description 6
- 229910052721 tungsten Inorganic materials 0.000 claims description 6
- 239000010937 tungsten Substances 0.000 claims description 6
- 229910003460 diamond Inorganic materials 0.000 claims description 4
- 239000010432 diamond Substances 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 229910000838 Al alloy Inorganic materials 0.000 claims description 3
- 239000000654 additive Substances 0.000 claims description 3
- 230000000996 additive effect Effects 0.000 claims description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 3
- 229910052782 aluminium Inorganic materials 0.000 claims description 3
- 150000004767 nitrides Chemical class 0.000 claims description 3
- 239000007789 gas Substances 0.000 description 37
- 238000000605 extraction Methods 0.000 description 9
- 230000002093 peripheral effect Effects 0.000 description 6
- 239000003570 air Substances 0.000 description 4
- 238000005229 chemical vapour deposition Methods 0.000 description 4
- 238000002844 melting Methods 0.000 description 4
- 230000008018 melting Effects 0.000 description 4
- 239000002243 precursor Substances 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000002826 coolant Substances 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000000110 cooling liquid Substances 0.000 description 1
- 239000000498 cooling water Substances 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000009206 nuclear medicine Methods 0.000 description 1
- 238000002600 positron emission tomography Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21K—TECHNIQUES FOR HANDLING PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR; IRRADIATION DEVICES; GAMMA RAY OR X-RAY MICROSCOPES
- G21K5/00—Irradiation devices
- G21K5/08—Holders for targets or for other objects to be irradiated
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/04—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators
- G21G1/10—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators by bombardment with electrically charged particles
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H6/00—Targets for producing nuclear reactions
Definitions
- the present application relates to a target system for the production of radioisotopes by irradiation of a gaseous target fluid under pressure by a charged particle beam, in particular a high energy beam, that is to say at least 1 MeV.
- positron emission tomography is an imaging technique that requires positron-emitting radioisotopes or molecules labeled with these same radioisotopes.
- a targeting system is installed at the output of a particle accelerator.
- a targeting system includes one or more targets to be irradiated. Each target has a radioisotope precursor which makes it possible to produce the corresponding radioisotope when the precursor has been irradiated.
- the targeting system is mounted at the output of a particle accelerator with a target in an axis of the particle beam emitted by the accelerator.
- the particle beam produced by the particle accelerator can irradiate the target of the targeting system to produce the radioisotope.
- the purpose of this application is to provide an improved gas targeting system, further leading to other benefits.
- a gas targeting system comprising:
- a body which includes:
- a cavity configured to contain a target gas to be irradiated with a particle beam emitted by a particle accelerator, the cavity comprising at least one truncated conical section, a closing bottom a broad base of the frustoconical section and an opening, opposite the bottom relative to the truncated conical section, forming an inlet for at least a part of the particle beam to enter the cavity;
- a cooling circuit comprising at least one channel that has an inlet and an outlet and surrounds at least a portion of the cavity, the channel being positioned as close as possible to the parts heated by an interaction of the particle beam with the gas contained in the cavity, ie for example a surface of the cavity and the window mentioned below;
- a window positioned opposite the entrance of the cavity to close the cavity, permeable to protons to allow introduction of protons from the particle beam emitted by the particle accelerator into the cavity, the window comprising a thin sheet permeable to at least a portion of the particle beam emitted by the particle accelerator and a support grid configured to support pressure differences between an interior of the cavity and an exterior of the targeting system, with the thin sheet positioned between the support grid and the cavity;
- a support-flange which holds the window and is fixed hermetically on the body, and which has a mechanical interface hooked at the output of a particle accelerator; the support-flange being further configured to hermetically seal the cavity and to at least ensure on the one hand a seal between an air outside the targeting system and a cooling fluid circulating in the cooling circuit, and on the other hand a seal between a vacuum formed in a beam line of the particle accelerator and a target gas under pressure contained in the cavity.
- Such a target system for the production of gaseous radioisotopes which has such a cavity which accommodates the target gas and which is sufficiently cooled by such a cooling circuit, thus allows the necessary nuclear reactions between said target gas and the protons incident in a more compact volume.
- the cooling circuit is for example unique to cool both the cavity and at least the thin sheet of the window.
- a gas target system for producing radioisotopes also allows a greater stability of production of radioisotopes and use at higher pressures than usual, in particular thanks to the cooling circuit which has been improved.
- a length of the cavity that is to say a distance between the inlet and the bottom of the cavity, can then be reduced, while having an "inverted cone” shape which takes into account the divergence phenomena of the beam protons when it collides with the target gas.
- This reduction in length nevertheless depends on the pressure differential.
- the system thus has a reduced compactness compared to the systems of the prior art which allows an increase in the effectiveness of radiation protection equipment because it allows to position these equipment closer to the nuclear reaction zones and increase if necessary thicknesses of constituent materials of these equipment for an identical external dimensions.
- the targeting system is a targeting system for producing 11 C radioisotopes by irradiating a target gas with a charged particle beam emitted by a particle accelerator.
- the cavity is configured to include a target gas at a pressure of between about 15 bar (1.5 MPa - megapascal) and about 50 bar (5 MPa), or between about 20 bar (2 MPa) and about 50 bar or between about 40 bar (4 MPa) and about 50 bar.
- a target gas at a pressure of between about 15 bar (1.5 MPa - megapascal) and about 50 bar (5 MPa), or between about 20 bar (2 MPa) and about 50 bar or between about 40 bar (4 MPa) and about 50 bar.
- a target gas pressure of at least 40 bars makes it possible, for example, to substantially reduce the depth of the cavity required to stop the particle beam.
- the cavity comprises a target gas which comprises at least one radioisotope precursor 11 C (carbon 1 1).
- the at least one radioisotope precursor 1 1 C comprises nitrogen gas ( 14 N).
- the window comprises a brazed assembly composed of the thin sheet positioned at the entrance to the cavity, allowing the charged particles to penetrate into the cavity, and the perforated support grid, which serves as a structural support for the thin sheet, configured to support a pressure differential created on either side of the window during use of the system, that is to say between the vacuum of the particle accelerator and the pressure of the gas filling the cavity .
- the support grid comprises for example equidistant holes and / or hexagonal shaped openings, for example honeycomb.
- the support grid has for example an empty surface / material ratio of between about 70% and about 90%, preferably between about 72% and about 85%.
- the support grid is for example tungsten or nitride aluminum.
- the support grid has for example a thickness of between about 1 mm (millimeter) and about 3 mm.
- the thin sheet is of small thickness, that is to say that it has a thickness equal to or less than 100 ⁇ , or even 80 ⁇ , or even 30 ⁇ , or even 20 ⁇ , for example depending on the chosen material.
- the thin sheet is for example tungsten; it then has for example a thickness of between about 20 ⁇ and about 30 ⁇ .
- the thin sheet is synthetic diamond CVD ("Chemical Vapor Deposition"), that is to say synthetic diamond obtained by a chemical vapor deposition process; it then has for example a thickness between about 70 ⁇ and about 80 ⁇ .
- synthetic diamond CVD Chemical Vapor Deposition
- the cooling circuit channel is formed in a wall of the body.
- the channel of the cooling circuit comprises at least one helical portion which surrounds at least a portion of the cavity.
- the helicoidal portion extends from the inlet of the channel, surrounds at least a portion of the cavity to the bottom of the cavity, and then still surrounds at least a portion of the cavity from the bottom to the exit of the canal.
- the body has a front surface that forms a bearing surface for at least a portion of the thin sheet of the window.
- both the inlet and the outlet of the channel open to the front surface of the body.
- the body has a groove, hollowed in the front surface of the body, surrounding at least part of the cavity inlet; the groove forming part of the cooling circuit.
- the cooling circuit thus makes it possible to limit not only the heating of the target gas contained in the cavity but also of the window during an irradiation of the target gas contained in the cavity.
- the inlet and the outlet of the canal open into the throat.
- the cooling circuit is for example non-cryogenic. It contains for example a coolant, for example a cooling water, which circulates in the circuit.
- the cooling circuit comprises a cooling fluid inlet, for example near the opening of the cavity.
- the cooling fluid inlet comprises a conduit communicating with the channel.
- the cooling fluid inlet is configured to circulate cooling fluid on the one hand in the helical portion of the channel, which surrounds the cavity configured to contain the gas to be irradiated, and on the other hand in the groove located opposite a periphery of the window.
- the cooling circuit also includes a cooling fluid extraction.
- the extraction of the cooling fluid is for example positioned next to the cooling fluid inlet.
- the arrival and / or extraction of cooling fluid communicate with the channel between the groove and the helical portion of the channel.
- the front surface of the body is orthogonal to a median central axis of the frustoconical section of the cavity and / or to an axis of propagation of the particle beam emitted by the particle accelerator.
- the flange-support forms a mechanical connection interface allowing both the maintenance of the window and the sealing of the interfaces between the coolant, the ambient air, the secondary vacuum (of the particle accelerator) and the target gas. (Of the cavity), for example by compression joints, for example O-rings.
- seals are positioned between a surface of the flange support and a surface of the corresponding body.
- the mechanical interface hooked at the output of a particle accelerator support-flange is configured to maintain the vacuum tightness of the beam line.
- the mechanical interface hooked at the output of a particle accelerator comprises for example a ring and a seal, for example an O-ring.
- the ring and the seal are, for example, held in the flange support.
- the window is inserted between the body and the support-flange, and for example, the support-flange is fixed screwed on the body.
- the front surface of the body has a seal, for example an O-ring
- a seal for example an O-ring
- / or the flange holder has a seal, for example an O-ring, possibly located opposite the seal of the front surface of the body.
- At least the thin sheet is jammed, compressed, between the seal of the body and the seal of the support-flange. This makes it possible, for example, to promote a seal between the cooling circuit, the target gas and the vacuum on the particle accelerator side when the system is mounted on the particle accelerator.
- the body comprises a passage communicating in the cavity through the bottom of the cavity, the passage being configured to fill the gas cavity and empty the cavity of said gas.
- the bottom of the cavity has a concave surface.
- the surface is for example rounded and concave.
- the body is made of AS7G6 aluminum alloy.
- the body is made by an additive manufacturing process, for example by selective laser melting (SLM process, “Selective Laser Melting”).
- SLM process selective laser melting
- the cooling circuit in a wall of the body, for example at least parts of the cooling fluid circulation channel closest to the window and / or an internal surface of the body (c that is to say a wall of the cavity), and / or to vary the shape of a duct, for example between a section of circular shape and a section of rectangular shape, to optimize heat exchange.
- the targeting system is possibly inscribed in a maximum size of about 50 x 63 x 120 mm.
- FIG. 1 shows a perspective view of a targeting system according to an exemplary embodiment of the present invention
- FIG. 2 is a sectional view of the system of FIG. 1 along a vertical plane (not shown),
- FIG. 3 is an exploded view of the system of FIGS. 1 and 2
- FIG. 4 shows an example of a temperature field (target heating) in degrees Celsius (° C) obtained by numerical simulation for an exemplary implementation of the system of FIGS. 1 to 3.
- Figures 1 to 4 illustrate a gas targeting system 100 according to an exemplary embodiment of the invention.
- the gas targeting system 100 comprises here:
- a cavity 120 configured to contain a target gas to be irradiated with a particle beam F emitted by a particle accelerator (not shown), the cavity 120 comprising at least one frustoconical section 121, a bottom 122 closing a broad base of the section 121 of frustoconical shape and an opening 12, opposite the bottom 122 relative to the section 121 of frustoconical shape, forming an inlet for at least a portion of the particle beam F enters the cavity 120;
- a cooling circuit 130 having at least one channel 140 which has an inlet 141 and an outlet 142 and surrounds at least a portion of the cavity 120;
- a window 150 positioned opposite the opening 12 of the cavity 120 for closing the cavity, permeable to protons to allow proton introduction of the particle beam F emitted by the particle accelerator into the cavity, the window 150 having a thin sheet 151, permeable to at least a portion of the particle beam F emitted by the particle accelerator and a support grid 152, configured to withstand pressure differences between an interior of the cavity 120 and an outside of the targeting system 100, with the thin sheet 151 positioned between the support grid 152 and the cavity 120; and a support-flange 160 which holds the window 150 and is hermetically fixed to the body 1 10, and which has a mechanical interface hooked at the output of a particle accelerator 170; the flange support 160 is furthermore configured to seal the cavity 120, for example by means of a specific flange 180 described below, and to at least ensure, on the one hand, a seal between an air at outside the targeting system and a cooling fluid circulating in the cooling circuit 130, and secondly a seal between a vacuum formed in a beam line of the
- Such a gas targeting system is particularly compact, as the figures show.
- radioisotopes for example 11 C.
- the body is for example a monobloc element.
- the body 1 10 here comprises a wall 1 1 1.
- the wall 1 1 1 delimits the cavity 120 and further comprises here, in its thickness, at least a portion of the cooling circuit.
- the body 1 10 comprises a flange 180 which has a front surface 181.
- the flange 180 comprises in particular a raised stud which comprises the front surface 181 and a peripheral surface delimiting a periphery of the stud, here orthogonal to the front surface 181.
- the flange 180 here has a substantially quadrilateral section, even square, as best illustrated in FIG.
- the flange 180 comprises, here, four holes 185.
- Each hole 185 here receives a bolt 186 which makes it possible to assemble the body 1 10 with the flange support 160.
- the body From the front surface 181, the body has an opening 112 from which the cavity 120 extends.
- the body 1 10 Around at least a portion of the opening January 12, and hollowed in the front surface 181, the body 1 10 has a groove 182 which, here, constitutes a part of the cooling circuit.
- the groove 182 preferably has a ring shape and surrounds the opening 1 12.
- the groove 182 thus allows a cooling of the window 150, at least a portion of the thin sheet 151 is here contiguous, in abutment, on the front surface 181, as is described later.
- the inlet 141 and the outlet 142 of the channel 140 open into the groove 182, which is why they are designated jointly in FIG.
- the body has a groove 183, hollowed in the front surface 181 and receiving a seal 184.
- the seal 184 serves here to support the thin sheet 151 of the window 150, helping to form a tight connection.
- the flange 180 further comprises here an inlet 187 and a cooling fluid extraction 188 for respectively conveying and extracting cooling liquid in the cooling circuit 130.
- the arrival 187 and the extraction 188 are of course arbitrarily represented and could obviously be interchanged with respect to each other.
- junctions with corresponding hoses They include here for example junctions with corresponding hoses.
- the arrival 187 and / or the extraction 188 comprise for example a conduit communicating with the channel, not visible in the figures.
- the arrival 187 and the extraction 188 communicate here with the channel 140, behind the entrance 141 and the exit 142 which here open in the groove 182 (in "back” extending here with respect to an introduction of the particle beam F into a cavity).
- the input 141 and the arrival 187 would be merged and / or the output 142 and the extraction 188 would be merged.
- the body 1 10 then comprises a main portion 190 which comprises a major part of the cavity 120.
- the main part 190 is for example cylindrical or in particular here a frustoconical portion which comprises at least the frustoconical section 121 of the cavity 120.
- the frustoconical main portion 190 of the body 1 10 flares from the flange 180, as the cavity 120 flares out from the opening 1 12 of the body, which also forms the opening 1 12, the inlet, of the cavity 120.
- a particle beam F can thus be introduced into the cavity 120 to irradiate the gas it contains in use.
- the body is closed by a bottom 191 which has the bottom 122 of the cavity 120.
- the bottom 122 of the cavity 120 is for example a rounded and concave surface, for example in the form of a dome.
- the cavity thus has a drop shape. It has a section increasing from the opening 1 12 to the bottom 122 (where the section narrows in its rounded shape).
- the bottom 191 of the body 1 10 further comprises a specific passage, which passes through the wall of the body and opens into the cavity 120.
- the gas targeting system 100 comprises a connection tip 192, for example a conventional connection 1/16 " , introduced into this specific passage and to fill or empty the cavity 120 of target gas.
- the cavity 120 is formed within the body 1 10, it is surrounded by the wall 1 1 1.
- the body 1 10 here comprises the channel 140 of the cooling circuit 130.
- the channel 140 here has a portion of helical shape, starting from the flange 180 of the body and extending towards the back of the body into the bottom 191 of the body, to return to the front part of the body, here also to the flange 180
- the channel 140 continues between the helical portion to the inlet 141 and outlet 142 which in this case open into the groove 182 of the flange 180 of the body 1 10.
- the channel 140 is here fed via the arrival 187 and extraction 188 of cooling fluid which communicate with the channel between the inlet 141 and outlet 142 of the channel 140 on the front surface 181 of the body on the one hand and the helicoidal portion of the channel 140 'somewhere else.
- the channel 140 surrounds the cavity 120 and is positioned as close as possible to the parts heated by an interaction of the particle beam F with the gas contained in the cavity 120, namely in particular the surface of the cavity (ie say an inner surface of the body) and the window 150.
- the gas targeting system 100 also includes the window 150 which includes the thin sheet 151 and the support grid 152.
- the window allows both the passage of the protons to the cavity and closes the latter with the support flange 160 described below.
- the front surface 181 possibly has a recess in which the window 150 is possibly deposited.
- the window is maintained on the body 1 10 with the support-flange 160, described below, favoring a support of the window on the front surface 181 of the body and to ensure the sealing air / vacuum secondary / Cooling fluid / target gas via the use of seals at the interfaces.
- the support grid 152 makes it possible to support the thin sheet 151 so as to accept pressure differences between the incident part of the secondary vacuum beam F (grid-support side) and the cavity 120 (thin side). sheet) under gas pressure for example between 20 and 50 bar when the system 100 is used.
- the thin sheet 151 is positioned between the support grid 152 and the front surface 181 of the body 1 10.
- the thin sheet 151 here covers at least a portion of the front surface 181, and in particular at least the groove 182 which surrounds at least in part the opening 1 12 of the cavity 120, to be cooled by the same cooling circuit 130 which the one that cools the cavity 120.
- the thin sheet covers both the opening 1 12, the groove 182 and is supported on the seal 184 located between the opening 1 12 and the groove 182.
- the support grid 152 is for example made of tungsten or nitride aluminum and has for example a thickness of between about 1 mm and about 3 mm.
- the support grid 152 has, for example, holes of circular or hexagonal shape.
- the thin sheet 151 is thin, that is to say it has a thickness equal to or less than 100 ⁇ .
- a thin sheet of tungsten it has for example a thickness between about 20 ⁇ and about 30 ⁇ ; while for a thin CVD synthetic diamond sheet, it has for example a thickness of between about 70 ⁇ and about 80 ⁇ .
- the gas targeting system 100 comprises the flange support 160.
- the flange support 160 is for example a massive element which here has a substantially quadrilateral section, in particular square.
- holes 161 opposite the holes 185 of the flange 180 to receive the bolts 186 which contribute to fix, tight, the flange support 160 to the flange 180 of the body.
- the flange support 160 has a groove 162, hollowed in a rear surface of the flange support 160, and receiving a seal 163.
- the seal 163 of the flange support 160 is thus opposite the seal 184 of the body 1 10.
- the window 150 is pinched, wedged, between the seal 163 of the support-flange 160 and the seal 184 of the body 1 10.
- the flange support 160 also has a groove 164 which receives a seal 165.
- the groove 164 is here cut into a peripheral wall, orthogonal here with a rear surface of the flange support 160 which is hollowed out in the flange support 160.
- the seal 165 surrounds the rear surface of the flange support 160.
- peripheral wall of the flange support 160 thus co-operates with the peripheral surface of the raised stud of the flange 180 of the body 1 10.
- the seal 165 is thus positioned between the peripheral wall of the rear surface of the flange support 160 and the peripheral surface of the raised stud of the flange 180 of the body 1 10.
- seal 165 surrounds, encloses, the raised stud of the flange 180 of the body 1 10.
- the seals 163 and 165 of the support flange 160 are thus disposed on either side of the groove 182 of the flange 180 of the body.
- the flange support 160 is thus configured to seal the cavity 120, for example in cooperation with the flange 180 of the body 1 10, and to at least ensure on the one hand a seal between an air outside the targeting system and the cooling fluid circulating in the cooling circuit 130, and on the other hand a seal between a vacuum formed in a beam line of the particle accelerator and the target gas under pressure contained in the cavity 120 when the system 100 is used.
- the flange support 160 has a mechanical interface hooked at the output of a particle accelerator 170.
- the mechanical interface hooked at the output of a particle accelerator 170 here comprises at least one ring 171 and an O-ring 172.
- the ring 171 and the O-ring 172 are here embedded in the flange support 160.
- the flange support 160 comprises, in front-face, a groove 166 which delimits a central block 167.
- the ring 171 is pressed into the groove 166 and the O-ring 172 encloses the central stud 167.
- the flange support 160 comprises for example an electronic target identification encoding center 168 which is for example an electronic element configured to identify the target.
- the electronic target identification encoding center 168 is here inserted into a housing provided for this purpose in a corner of the front face of the support-flange 160 and is for example attached to it by a removable fastening element, such as for example a screw.
- FIG. 4 shows that, in use, the gas targeting system 100 described previously has a maximum heating at the level of the window 150 which is less than 515 ° C., in particular of the order of 478-512 ° C., while the outer surface, the casing, of the system 100 remains at a temperature below about 85 ° C, in particular between about
- a surface of the cavity 120 is maintained at a temperature below about 249 ° C, or even below about 200 ° C by the cooling system.
Landscapes
- Physics & Mathematics (AREA)
- High Energy & Nuclear Physics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Optics & Photonics (AREA)
- Plasma & Fusion (AREA)
- Spectroscopy & Molecular Physics (AREA)
- General Chemical & Material Sciences (AREA)
- Particle Accelerators (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1663237A FR3061403B1 (fr) | 2016-12-22 | 2016-12-22 | Systeme de ciblerie a gaz pour production de radio-isotopes |
PCT/FR2017/053679 WO2018115705A1 (fr) | 2016-12-22 | 2017-12-19 | Système de ciblerie à gaz pour production de radio-isotopes |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3560302A1 true EP3560302A1 (fr) | 2019-10-30 |
EP3560302B1 EP3560302B1 (fr) | 2022-04-20 |
Family
ID=59031010
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP17828971.6A Active EP3560302B1 (fr) | 2016-12-22 | 2017-12-19 | Système de ciblerie à gaz pour production de radio-isotopes |
Country Status (11)
Country | Link |
---|---|
US (1) | US11145430B2 (fr) |
EP (1) | EP3560302B1 (fr) |
JP (1) | JP7096825B2 (fr) |
CN (1) | CN110089201A (fr) |
AU (1) | AU2017380416B2 (fr) |
CA (1) | CA3047017A1 (fr) |
ES (1) | ES2922485T3 (fr) |
FR (1) | FR3061403B1 (fr) |
PL (1) | PL3560302T3 (fr) |
UY (1) | UY37535A (fr) |
WO (1) | WO2018115705A1 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA202090056A1 (ru) * | 2017-06-29 | 2020-04-13 | Зе Саус Африкан Нюклиар Энерджи Корпорейшен Сок Лимитед | Получение радиоизотопов |
CZ309802B6 (cs) * | 2021-04-16 | 2023-10-25 | Extreme Light Infrastructure ERIC (ELI ERIC) | Jaderný terčík, způsob indukce jaderné reakce s tímto jaderným terčíkem a zařízení na výrobu radioizotopů s tímto jaderným terčíkem |
CN114585145B (zh) * | 2022-03-10 | 2023-03-07 | 中国原子能科学研究院 | 一种用于医用同位素生产气体靶的冷却机构和方法 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5193100U (fr) * | 1976-01-08 | 1976-07-26 | ||
US5764715A (en) * | 1996-02-20 | 1998-06-09 | Sandia Corporation | Method and apparatus for transmutation of atomic nuclei |
US5917874A (en) * | 1998-01-20 | 1999-06-29 | Brookhaven Science Associates | Accelerator target |
US6917044B2 (en) * | 2000-11-28 | 2005-07-12 | Behrouz Amini | High power high yield target for production of all radioisotopes for positron emission tomography |
US20040100214A1 (en) * | 2002-05-13 | 2004-05-27 | Karl Erdman | Particle accelerator assembly with high power gas target |
DE60323832D1 (de) * | 2002-05-21 | 2008-11-13 | Univ Duke | Batch-target und verfahren zur erzeugung eines radionuklids |
WO2008149600A1 (fr) * | 2007-06-08 | 2008-12-11 | Sumitomo Heavy Industries, Ltd. | Système de production de radio isotope et procédé de production de radioisotope |
EP2171724A1 (fr) * | 2007-06-22 | 2010-04-07 | Advanced Applied Physics Solutions, Inc. | Système de cible modulaire à pression plus élevée pour la production de radioisotopes |
KR100967359B1 (ko) * | 2008-04-30 | 2010-07-05 | 한국원자력연구원 | 내부 핀구조를 가지는 동위원소 생산 기체표적 |
KR101065057B1 (ko) * | 2009-05-20 | 2011-09-15 | 재단법인 한국원자력의학원 | 냉각 성능이 향상된 동위원소 생산용 중수 표적장치 |
US9693443B2 (en) * | 2010-04-19 | 2017-06-27 | General Electric Company | Self-shielding target for isotope production systems |
US9336916B2 (en) * | 2010-05-14 | 2016-05-10 | Tcnet, Llc | Tc-99m produced by proton irradiation of a fluid target system |
US9336915B2 (en) * | 2011-06-17 | 2016-05-10 | General Electric Company | Target apparatus and isotope production systems and methods using the same |
CN202998639U (zh) * | 2012-12-11 | 2013-06-12 | 中国科学院近代物理研究所 | 加速器与无窗散裂靶界面耦合系统 |
CN106102782B (zh) * | 2014-03-24 | 2019-12-03 | 利乐拉瓦尔集团及财务有限公司 | 电子束发射器 |
US20160141062A1 (en) * | 2014-11-19 | 2016-05-19 | General Electric Company | Target body for an isotope production system and method of using the same |
-
2016
- 2016-12-22 FR FR1663237A patent/FR3061403B1/fr active Active
-
2017
- 2017-12-19 PL PL17828971.6T patent/PL3560302T3/pl unknown
- 2017-12-19 CN CN201780079376.8A patent/CN110089201A/zh active Pending
- 2017-12-19 CA CA3047017A patent/CA3047017A1/fr active Pending
- 2017-12-19 WO PCT/FR2017/053679 patent/WO2018115705A1/fr unknown
- 2017-12-19 JP JP2019533559A patent/JP7096825B2/ja active Active
- 2017-12-19 US US16/472,267 patent/US11145430B2/en active Active
- 2017-12-19 ES ES17828971T patent/ES2922485T3/es active Active
- 2017-12-19 AU AU2017380416A patent/AU2017380416B2/en active Active
- 2017-12-19 EP EP17828971.6A patent/EP3560302B1/fr active Active
- 2017-12-20 UY UY0001037535A patent/UY37535A/es unknown
Also Published As
Publication number | Publication date |
---|---|
ES2922485T3 (es) | 2022-09-15 |
CA3047017A1 (fr) | 2018-06-28 |
JP2020514706A (ja) | 2020-05-21 |
PL3560302T3 (pl) | 2022-12-27 |
EP3560302B1 (fr) | 2022-04-20 |
FR3061403B1 (fr) | 2023-02-17 |
CN110089201A (zh) | 2019-08-02 |
US20190333654A1 (en) | 2019-10-31 |
FR3061403A1 (fr) | 2018-06-29 |
WO2018115705A1 (fr) | 2018-06-28 |
AU2017380416B2 (en) | 2022-06-30 |
UY37535A (es) | 2018-07-31 |
AU2017380416A1 (en) | 2019-07-18 |
US11145430B2 (en) | 2021-10-12 |
JP7096825B2 (ja) | 2022-07-06 |
BR112019012829A2 (pt) | 2019-11-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP3560302B1 (fr) | Système de ciblerie à gaz pour production de radio-isotopes | |
EP1429345A1 (fr) | Dispositif et procédé de production de radio-isotopes | |
EP3574506B1 (fr) | Reacteur nucleaire integrant un echangeur de chaleur primaire de securite | |
EP3167456B1 (fr) | Conteneur, son procédé d'obtention, et ensemble de cible pour la production de radio-isotopes utilisant un tel conteneur | |
EP2633527B1 (fr) | Dispositif destiné à la production de radioisotopes | |
CA3037652A1 (fr) | Compresseur d'hydrogene a hydrure metallique | |
FR2792493A1 (fr) | Cartouche pour torche a plasma et torche a plasma equipee | |
EP3548825B1 (fr) | Dispositif de distribution d'un fluide réfrigérant à l'intérieur d'une boîte collectrice d'un échangeur thermique | |
BE1019054A3 (fr) | Dispositif de production de radio-isotopes. | |
EP2861928B1 (fr) | Dispositif de contrôle thermique | |
EP2050100B1 (fr) | Système de délivrance de faisceau de rayons x stabilisé | |
FR3064753A1 (fr) | Systeme de generation d’un champ magnetique vectoriel | |
EP3245447B1 (fr) | Module d'eclairage a diodes a refroidissement ameliore | |
FR3088143A1 (fr) | Ensemble de refroidissement, notamment pour batterie de vehicule | |
EP0128092A1 (fr) | Dispositif de couverture de réacteur à fusion nucléaire utilisant la réaction deutérium tritium, à matériau tritigène solide | |
FR3045440A1 (fr) | Dispositif de regulation de la temperature d'un moule par diode vcsel | |
EP0517638A1 (fr) | Tuyère modulaire à refroidissement par film d'eau notamment pour essais à haute température d'éprouvettes ou analogues | |
EP4281268A1 (fr) | Dispositif de chauffage par induction adapté au moulage d'une pièce de petite dimension | |
CA3214895A1 (fr) | Structure regulatrice de chaleur par caloduc optimisee pour panneaux supports d'equipements electroniques | |
FR2670046A1 (fr) | Reacteur nucleaire a eau sous pression et a cloisonnement massif. | |
CA3142844A1 (fr) | Absorbeur hybride de rayonnements pour centrale solaire, et procede de preparation d'un tel absorbeur | |
WO2018078253A1 (fr) | Echangeur thermique et procédé de fabrication d'un échangeur thermique | |
JPH08160195A (ja) | 分光素子 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: UNKNOWN |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
17P | Request for examination filed |
Effective date: 20190627 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
AX | Request for extension of the european patent |
Extension state: BA ME |
|
DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) | ||
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: GRANT OF PATENT IS INTENDED |
|
INTG | Intention to grant announced |
Effective date: 20211124 |
|
GRAS | Grant fee paid |
Free format text: ORIGINAL CODE: EPIDOSNIGR3 |
|
GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE PATENT HAS BEEN GRANTED |
|
AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
REG | Reference to a national code |
Ref country code: GB Ref legal event code: FG4D Free format text: NOT ENGLISH |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: EP |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R096 Ref document number: 602017056332 Country of ref document: DE |
|
REG | Reference to a national code |
Ref country code: IE Ref legal event code: FG4D Free format text: LANGUAGE OF EP DOCUMENT: FRENCH |
|
REG | Reference to a national code |
Ref country code: AT Ref legal event code: REF Ref document number: 1486190 Country of ref document: AT Kind code of ref document: T Effective date: 20220515 |
|
REG | Reference to a national code |
Ref country code: NL Ref legal event code: FP |
|
REG | Reference to a national code |
Ref country code: SE Ref legal event code: TRGR |
|
REG | Reference to a national code |
Ref country code: LT Ref legal event code: MG9D |
|
REG | Reference to a national code |
Ref country code: ES Ref legal event code: FG2A Ref document number: 2922485 Country of ref document: ES Kind code of ref document: T3 Effective date: 20220915 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: PT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20220822 Ref country code: NO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20220720 Ref country code: LT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20220420 Ref country code: HR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20220420 Ref country code: GR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20220721 Ref country code: FI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20220420 Ref country code: BG Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20220720 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: RS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20220420 Ref country code: LV Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20220420 Ref country code: IS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20220820 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R097 Ref document number: 602017056332 Country of ref document: DE |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: SM Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20220420 Ref country code: SK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20220420 Ref country code: RO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20220420 Ref country code: EE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20220420 Ref country code: DK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20220420 Ref country code: CZ Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20220420 |
|
PLBE | No opposition filed within time limit |
Free format text: ORIGINAL CODE: 0009261 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT |
|
26N | No opposition filed |
Effective date: 20230123 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: AL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20220420 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: SI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20220420 |
|
REG | Reference to a national code |
Ref country code: AT Ref legal event code: UEP Ref document number: 1486190 Country of ref document: AT Kind code of ref document: T Effective date: 20220420 |
|
P01 | Opt-out of the competence of the unified patent court (upc) registered |
Effective date: 20230706 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LU Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20221219 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: IE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20221219 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: NL Payment date: 20231122 Year of fee payment: 7 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: GB Payment date: 20231113 Year of fee payment: 7 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: SE Payment date: 20231123 Year of fee payment: 7 Ref country code: IT Payment date: 20231122 Year of fee payment: 7 Ref country code: FR Payment date: 20231227 Year of fee payment: 7 Ref country code: DE Payment date: 20231122 Year of fee payment: 7 Ref country code: AT Payment date: 20231122 Year of fee payment: 7 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: PL Payment date: 20231201 Year of fee payment: 7 Ref country code: BE Payment date: 20231121 Year of fee payment: 7 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: HU Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO Effective date: 20171219 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: ES Payment date: 20240111 Year of fee payment: 7 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: CY Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20220420 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: CH Payment date: 20240101 Year of fee payment: 7 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: MK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20220420 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: MC Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20220420 |