EP3554700C0 - Thermalizing microfluidic chip employing variable temperature cycles, system using such a chip and pcr method for detecting dna sequences - Google Patents

Thermalizing microfluidic chip employing variable temperature cycles, system using such a chip and pcr method for detecting dna sequences

Info

Publication number
EP3554700C0
EP3554700C0 EP17822628.8A EP17822628A EP3554700C0 EP 3554700 C0 EP3554700 C0 EP 3554700C0 EP 17822628 A EP17822628 A EP 17822628A EP 3554700 C0 EP3554700 C0 EP 3554700C0
Authority
EP
European Patent Office
Prior art keywords
chip
thermalizing
dna sequences
pcr method
variable temperature
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP17822628.8A
Other languages
German (de)
French (fr)
Other versions
EP3554700A1 (en
EP3554700B1 (en
Inventor
Maël Leberre
Adrien Plessis
Walter Minnella
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bforcure
Original Assignee
Bforcure
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR1601823A external-priority patent/FR3060418B1/en
Priority claimed from FR1762058A external-priority patent/FR3074810B1/en
Application filed by Bforcure filed Critical Bforcure
Publication of EP3554700A1 publication Critical patent/EP3554700A1/en
Application granted granted Critical
Publication of EP3554700B1 publication Critical patent/EP3554700B1/en
Publication of EP3554700C0 publication Critical patent/EP3554700C0/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F28—HEAT EXCHANGE IN GENERAL
    • F28F—DETAILS OF HEAT-EXCHANGE AND HEAT-TRANSFER APPARATUS, OF GENERAL APPLICATION
    • F28F3/00—Plate-like or laminated elements; Assemblies of plate-like or laminated elements
    • F28F3/12—Elements constructed in the shape of a hollow panel, e.g. with channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1838—Means for temperature control using fluid heat transfer medium
    • B01L2300/185—Means for temperature control using fluid heat transfer medium using a liquid as fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F28—HEAT EXCHANGE IN GENERAL
    • F28F—DETAILS OF HEAT-EXCHANGE AND HEAT-TRANSFER APPARATUS, OF GENERAL APPLICATION
    • F28F2260/00—Heat exchangers or heat exchange elements having special size, e.g. microstructures
    • F28F2260/02—Heat exchangers or heat exchange elements having special size, e.g. microstructures having microchannels

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Mechanical Engineering (AREA)
  • Thermal Sciences (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
EP17822628.8A 2016-12-19 2017-12-14 Thermalizing microfluidic chip employing variable temperature cycles, system using such a chip and pcr method for detecting dna sequences Active EP3554700B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1601823A FR3060418B1 (en) 2016-12-19 2016-12-19 MICROFLUIDIC CHIP, SYSTEM USING SUCH A CHIP, AND PCR METHOD FOR THE DETECTION OF DNA SEQUENCES
FR1762058A FR3074810B1 (en) 2017-12-13 2017-12-13 MICRO-FLUIDIC SAMPLE CHIP, ANALYSIS SYSTEM USING SUCH A CHIP AND PCR PROCESS FOR DETECTION OF DNA SEQUENCES
PCT/EP2017/082898 WO2018114620A1 (en) 2016-12-19 2017-12-14 Thermalizing microfluidic chip employing variable temperature cycles, system using such a chip and pcr method for detecting dna sequences

Publications (3)

Publication Number Publication Date
EP3554700A1 EP3554700A1 (en) 2019-10-23
EP3554700B1 EP3554700B1 (en) 2024-02-21
EP3554700C0 true EP3554700C0 (en) 2024-02-21

Family

ID=60888397

Family Applications (2)

Application Number Title Priority Date Filing Date
EP17822628.8A Active EP3554700B1 (en) 2016-12-19 2017-12-14 Thermalizing microfluidic chip employing variable temperature cycles, system using such a chip and pcr method for detecting dna sequences
EP17822629.6A Pending EP3554701A1 (en) 2016-12-19 2017-12-14 Microfluidic sample chip, assay system using such a chip, and pcr method for detecting dna sequences

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP17822629.6A Pending EP3554701A1 (en) 2016-12-19 2017-12-14 Microfluidic sample chip, assay system using such a chip, and pcr method for detecting dna sequences

Country Status (4)

Country Link
US (3) US11198120B2 (en)
EP (2) EP3554700B1 (en)
CN (2) CN110191759B (en)
WO (2) WO2018114625A1 (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3743524A4 (en) * 2018-01-22 2021-10-27 University of Washington Methods of performing digital nucleic acid amplification using polybutene
IT201800006089A1 (en) * 2018-06-06 2019-12-06 MICROFLUIDIC DEVICE FOR THE CONCENTRATION OF PARTICLES
CN110554651B (en) * 2019-09-19 2021-07-30 哈尔滨工业大学 Private Internet of things system for measuring and controlling temperature of microfluidic chip
CN110756236B (en) * 2019-11-18 2021-12-17 江苏纳迪芯生命科技研究院有限公司 Sealed micro-fluidic emulsification chip and manufacturing process and using method thereof
EP3831490A1 (en) * 2019-12-03 2021-06-09 Eppendorf AG Thermal block for receiving and tempering at least one laboratory sample vessel, production method and simulation method
EP3838411A1 (en) * 2019-12-18 2021-06-23 TECAN Trading AG Pipetting device and method
CN111185248A (en) * 2020-01-19 2020-05-22 中国科学院上海微系统与信息技术研究所 Polymerase chain reaction chip containing bubble elimination structure and treatment method of liquid drop emulsion
FR3117045A1 (en) 2020-12-04 2022-06-10 Bforcure PCR detection chip, associated test device and implementation analysis system
CN114618599A (en) * 2020-12-14 2022-06-14 京东方科技集团股份有限公司 Heating temperature control device and micro-fluidic system
CN112684320B (en) * 2020-12-17 2023-01-31 海光信息技术股份有限公司 Chip low-temperature testing environment bin and chip testing machine
CN113720834B (en) * 2021-08-25 2023-08-18 中国科学院南海海洋研究所 Microfluidic chip, system and method for detecting biochemical elements of water body
FR3136386A1 (en) 2022-06-08 2023-12-15 Bforcure PCR detection chip, related test apparatus and implementation analysis system
CN115651824A (en) * 2022-06-27 2023-01-31 杭州聚致生物科技有限公司 PCR reaction system and method

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US5637469A (en) * 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5508197A (en) 1994-07-25 1996-04-16 The Regents, University Of California High-speed thermal cycling system and method of use
US5958349A (en) 1997-02-28 1999-09-28 Cepheid Reaction vessel for heat-exchanging chemical processes
US6143496A (en) 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
JP5046412B2 (en) 2000-04-06 2012-10-10 カリパー・ライフ・サイエンシズ・インク． Microfluidic device and system incorporating a coating layer
US7440684B2 (en) 2001-04-12 2008-10-21 Spaid Michael A Method and apparatus for improved temperature control in microfluidic devices
TWI273240B (en) * 2004-09-27 2007-02-11 Univ Nat Cheng Kung Reverse transcription polymerase chain reaction chip
KR100773552B1 (en) * 2006-04-28 2007-11-07 삼성전자주식회사 Micro-fluid reaction vessel, method for manufacturing the vessel, and method of micro-fluid reaction using the vessel
EP2240600B1 (en) 2007-08-29 2013-03-13 Plexera Bioscience Llc Microfluidic apparatus for wide area microarrays
US9034635B2 (en) 2008-02-20 2015-05-19 Streck, Inc. Thermocycler and sample vessel for rapid amplification of DNA
CN105154326A (en) * 2009-03-31 2015-12-16 财团法人神奈川科学技术研究院 Liquid reflux high-speed gene amplification device
FR2959678B1 (en) 2010-05-04 2012-09-28 Centre Nat Rech Scient MICROFLUIDIC CHIP, SUPPORT, SYSTEM AND METHOD FOR IMPLEMENTING SPATIALLY CONTROLLED AND FAST THERMAL CONTROL OF A SAMPLE
WO2013072790A1 (en) * 2011-11-16 2013-05-23 International Business Machines Corporation Microfluidic device with deformable valve
TWI582425B (en) * 2011-11-25 2017-05-11 凸版印刷股份有限公司 Sample analysis chip, sample analysis method, and gene analysis method
JP5912034B2 (en) 2011-11-28 2016-04-27 公益財団法人神奈川科学技術アカデミー Liquid reflux type high-speed gene amplification device
CN102994369B (en) * 2012-12-14 2014-12-31 张影频 Chip structure for PCR (polymerase chain reaction) rapid reaction
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EP3285928B1 (en) 2015-04-22 2020-04-08 Stilla Technologies Contact-less priming method for loading a solution in a microfluidic device and associated system

Also Published As

Publication number Publication date
US20220097049A1 (en) 2022-03-31
WO2018114625A1 (en) 2018-06-28
US20190388887A1 (en) 2019-12-26
EP3554700A1 (en) 2019-10-23
CN110191759A (en) 2019-08-30
US11198120B2 (en) 2021-12-14
CN110191759B (en) 2022-10-11
EP3554701A1 (en) 2019-10-23
EP3554700B1 (en) 2024-02-21
WO2018114620A1 (en) 2018-06-28
CN110191758B (en) 2022-10-14
US20200016593A1 (en) 2020-01-16
US11607684B2 (en) 2023-03-21
CN110191758A (en) 2019-08-30

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