EP3554527A1 - Préparations salines de peptides splunc1 - Google Patents

Préparations salines de peptides splunc1

Info

Publication number
EP3554527A1
EP3554527A1 EP17832396.0A EP17832396A EP3554527A1 EP 3554527 A1 EP3554527 A1 EP 3554527A1 EP 17832396 A EP17832396 A EP 17832396A EP 3554527 A1 EP3554527 A1 EP 3554527A1
Authority
EP
European Patent Office
Prior art keywords
seq
polypeptide
sodium channel
pharmaceutical composition
homolog
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP17832396.0A
Other languages
German (de)
English (en)
Inventor
Timothy Morgan CROWDER
David W. Scott
John Clayton TAYLOR
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Spyryx Biosciences Inc
Original Assignee
Spyryx Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spyryx Biosciences Inc filed Critical Spyryx Biosciences Inc
Publication of EP3554527A1 publication Critical patent/EP3554527A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

Abstract

La présente invention concerne des préparations pharmaceutiques de peptides spécialisés d'origine non naturelle destinés à se lier à des canaux sodiques et à inhiber l'activation desdits canaux sodiques. L'invention concerne, en outre, des méthodes de régulation de l'absorption du sodium et d'un volume de fluide, et de traitement de troubles sensibles à la modulation de l'absorption du sodium par modulation de la liaison de peptides spécialisés d'origine non naturelle aux canaux sodiques.
EP17832396.0A 2016-12-13 2017-12-12 Préparations salines de peptides splunc1 Withdrawn EP3554527A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662433549P 2016-12-13 2016-12-13
PCT/US2017/065862 WO2018111903A1 (fr) 2016-12-13 2017-12-12 Préparations salines de peptides splunc1

Publications (1)

Publication Number Publication Date
EP3554527A1 true EP3554527A1 (fr) 2019-10-23

Family

ID=61006312

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17832396.0A Withdrawn EP3554527A1 (fr) 2016-12-13 2017-12-12 Préparations salines de peptides splunc1

Country Status (3)

Country Link
EP (1) EP3554527A1 (fr)
CA (1) CA3046361A1 (fr)
WO (1) WO2018111903A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111317712A (zh) * 2020-02-27 2020-06-23 南京致中生物科技有限公司 一种盐酸左氧氟沙星注射液及其制备方法
WO2023141458A1 (fr) * 2022-01-18 2023-07-27 Emory University Traitement de la bronchiectasie

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US4501729A (en) 1982-12-13 1985-02-26 Research Corporation Aerosolized amiloride treatment of retained pulmonary secretions
US4957735A (en) 1984-06-12 1990-09-18 The University Of Tennessee Research Corporation Target-sensitive immunoliposomes- preparation and characterization
US20080260863A1 (en) * 2007-04-20 2008-10-23 Pre Holding, Inc. Compositions for mucociliary clearance and methods for administering same
WO2010138794A2 (fr) 2009-05-29 2010-12-02 The University Of North Carolina At Chapel Hill Régulation des canaux sodiques par des protéines plunc
ES2716723T3 (es) 2011-09-20 2019-06-14 Univ North Carolina Chapel Hill Regulación de los canales de sodio por las proteínas PLUNC
SG11201702769QA (en) * 2014-10-08 2017-05-30 Univ North Carolina Improved peptide inhibitors of sodium channels
AU2017222450A1 (en) * 2016-02-22 2018-09-27 The University Of North Carolina At Chapel Hill Peptide inhibitors of calcium channels

Also Published As

Publication number Publication date
WO2018111903A1 (fr) 2018-06-21
CA3046361A1 (fr) 2018-06-21

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