EP3541350B1 - Compositions de soins buccodentaires - Google Patents

Compositions de soins buccodentaires Download PDF

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Publication number
EP3541350B1
EP3541350B1 EP17754587.8A EP17754587A EP3541350B1 EP 3541350 B1 EP3541350 B1 EP 3541350B1 EP 17754587 A EP17754587 A EP 17754587A EP 3541350 B1 EP3541350 B1 EP 3541350B1
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EP
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Prior art keywords
weight
composition
arginine
oral care
amount
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German (de)
English (en)
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EP3541350A1 (fr
Inventor
Aarti Rege
Michael Prencipe
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Colgate Palmolive Co
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Colgate Palmolive Co
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Priority to EP23174699.1A priority Critical patent/EP4241757A3/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A61K8/21—Fluorides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8164—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers, e.g. poly (methyl vinyl ether-co-maleic anhydride)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/48—Thickener, Thickening system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/92—Oral administration

Definitions

  • the present invention relates to a high water oral care composition as defined in the claims, in particular for use in a method of treatment or prevention of erosive tooth demineralization, gingivitis, plaque, and dental caries.
  • This oral care composition includes zinc phosphate, stannous fluoride, anionic polymer, and a basic amino acid, as defined in the claims.
  • Dental erosion involves demineralization and damage to the tooth structure due to acid attack from nonbacterial sources. Erosion is found initially in the enamel and, if unchecked, may proceed to the underlying dentin. Dental erosion may be caused or exacerbated by acidic foods and drinks, exposure to chlorinated swimming pool water, and regurgitation of gastric acids.
  • Dental plaque is a sticky biofilm or mass of bacteria that is commonly found between the teeth, along the gum line, and below the gum line margins. Dental plaque can give rise to dental caries and periodontal problems such as gingivitis and periodontitis. Dental caries tooth decay or tooth demineralization caused by acid produced from the bacterial degradation of fermentable sugar.
  • Oral care compositions which contain stannous ion sources exhibit excellent clinical benefits, particularly in the reduction of gingivitis and in the treatment or prevention of erosive tooth demineralization.
  • Stannous fluoride is well known for use in clinical dentistry with a history of therapeutic benefits over forty years. However, until recently, its popularity has been limited by its instability in aqueous solutions. The instability of stannous fluoride in water is primarily due to the reactivity of the stannous ion (Sn 2+ ). Stannous salts readily hydrolyze above a pH of 4, resulting in precipitation from solution, with a consequent loss of the therapeutic properties.
  • Soluble zinc salts such as zinc citrate
  • Zinc ions in solution impart an unpleasant, astringent mouthfeel, so formulations that provide effective levels of zinc, and also have acceptable organoleptic properties, have been difficult to achieve.
  • free zinc ions may react with fluoride ions to produce zinc fluoride, which is insoluble and so reduces the availability of both the zinc and the fluoride.
  • anionic surfactants such as sodium lauryl sulfate
  • Zinc phosphate (Zn 3 (PO 4 ) 2 ) is insoluble in water, although soluble in acidic or basic solutions, e.g., solutions of mineral acids, acetic acid, ammonia, or alkali hydroxides. See, e.g., Merck Index, 13th Ed. (2001) p. 1812, monograph number 10205 .
  • acidic or basic solutions e.g., solutions of mineral acids, acetic acid, ammonia, or alkali hydroxides.
  • monograph number 10205 e.g., Merck Index, 13th Ed. (2001) p. 1812, monograph number 10205 .
  • zinc phosphate is commonly used in dental cements, for example in cementation of inlays, crowns, bridges, and orthodontic appliances, which are intended to endure in the mouth for many years.
  • Zinc phosphate dental cements are generally prepared by mixing zinc oxide and magnesium oxide powders with a liquid consisting principally of phosphoric acid, water, and buffers, so the cement comprising zinc phosphate is formed in situ by reaction with phosphoric acid.
  • WO2014088573 discloses formulations comprising zinc ions together with fluoride.
  • US2016324738 is directed to oral compositions containing metal ions including stannous and optionally zinc in combination with a mineral surface active agent and fluoride ions.
  • the present invention refers to the high water oral care compositions as defined in the claims.
  • the compositions disclosed herein provide improved protection from demineralization and enhanced antibacterial activity compared to the prior art.
  • the zinc phosphate is added to the dentifrice as a preformed salt.
  • the anionic polymer is a methyl vinyl ether/maleic acid or anhydride copolymer.
  • the basic amino acid is selected from lysine or arginine.
  • the oral care composition is a toothpaste or oral gel composition.
  • ranges are used as shorthand for describing each and every value that is within the range. Any value within the range can be selected as the terminus of the range. In the event of a conflict in a definition in the present disclosure and that of a cited reference, the present disclosure controls.
  • a high water oral care composition comprising zinc phosphate, stannous fluoride, an anionic polymer, and a basic amino acid, selected at certain concentrations and amounts, is unexpectedly more efficacious in boosting the anti-erosion and anti-microbial properties of a zinc and stannous ions containing formulation when compared to formulations according to the prior art.
  • the term "high waterā€ refers to an oral care composition, such as a toothpaste or oral gel, which comprises from 10% to 99% water, by weight of the composition.
  • the composition may comprise at least 10%, 15%, 20%, 25%, 30%, 35% or 40% water, up to a maximum of, for example, 60%, 70%, 80%, 90%, 95% or 99% water, by weight of the composition.
  • amounts of water refer to water added directly to the composition, as well as water added as part of ingredients or components which are added as aqueous solutions.
  • the composition comprises 10-60% water, or 10-50% water, or 10-40% water, or 10-30% water, or 15-30% water, or 20-30% water, or about 25% water, by weight of the composition.
  • the term "preformed salt" - when used in reference to zinc phosphate - means that the zinc phosphate is not formed in situ in the oral care composition, e.g., through the reaction of phosphoric acid and another zinc salt.
  • the present invention refers to the high water oral care compositions as defined in the claims, in particular for use in a method of treatment as defined in the claims.
  • the zinc phosphate is a preformed salt of zinc phosphate (e.g., zinc phosphate hydrate).
  • the zinc phosphate is present in an amount sufficient so that the stannous fluoride dissociates to provide a therapeutically effective amount of stannous ions in aqueous solution.
  • the amount of zinc phosphate is from 0.05 to 10% by weight, relative to the weight of the oral care composition, for example, from 0.1 to 8% by weight, or from 0.5 to 5% by weight, or from 0.5 to 4% by weight, or from 1 to 4%, or from 1 to 3% by weight, or from 2 to 3% by weight, or about 1% or about 2%, or about 2.25% or about 2.5%, by weight.
  • the amount of the stannous fluoride is from 0.01% to 5% by weight, relative to the weight of the oral care composition, for example, from 0.05 to 4% by weight, or from 0.1% to 3% by weight, or from 0.2 to 2% by weight, or from 0.3 to 1% by weight, or from 0.4 to 0.8% by weight, or from 0.4 to 0.6% by weight, or from 0.4 to 0.5% by weight, or about 0.45% by weight (e.g., 0.454% by weight).
  • the basic amino acid is selected from arginine.
  • the basic amino acid can be L-arginine, in free or orally acceptable salt form, e.g., arginine phosphate, arginine citrate, arginine hydrochloride, arginine carbonate, arginine bicarbonate, or arginine sulfate.
  • Arginine is present in an amount of 0. 1 to 10% by weight of the composition (calculated as free base amount), for example, 0.1 to 5%, or 0.5 to 5%, or 1 to 4%, or 1 to 3%, or 2 to 3%, or about 2% or about 2.5% by weight.
  • the amount of the water is 10% to 99% by weight, relative to the weight of the oral care composition, for example, 10-90%, or 10-80%, or 10-70%, or 10-60%, or 10-50%, or 10-40%, or 10-30%, or 15-30%, or 20-30%, or about 25%, by weight of the composition.
  • the anionic polymer is a methyl vinyl ether/maleic anhydride or acid copolymer having an average molecular weight (M.W.) of 30,000 to 1,000,000, e.g., 300,000 to 800,000.
  • the anionic polymer can be present in an amount of 1 to 20% by weight of the composition, e.g., from 5 to 20%, or from 8 to 15%, or from 10 to 14%, or from 11 to 13%, or about 12%
  • composition can, further comprise an organic acid buffer system, e.g., an buffer system comprising a carboxylic acid and one or more conjugate base salts thereof, for example, alkali metal salts thereof.
  • organic acid buffer system e.g., an buffer system comprising a carboxylic acid and one or more conjugate base salts thereof, for example, alkali metal salts thereof.
  • the acid can be selected from citric acid, lactic acid, malic acid, maleic acid, fumaric acid, acetic acid, succinic acid, and tartaric acid.
  • the one or more conjugate base salts can be independently selected from sodium and potassium salts, or combinations thereof.
  • the acid can be citric acid
  • the one or more conjugate base salts can comprise monosodium citrate (monobasic), disodium citrate (dibasic), trisodium citrate (tribasic), and combinations thereof.
  • the composition can comprise the organic acid buffer system in an amount of 0.1 to 5.0% by weight of the composition, measured as the combined amount of organic acid and any conjugate base salts; for example, from 0.5 to 4.0%, or from 1.0 to 3.0%, or from 1.5 to 3.0%, or from 1.0 to 2.4%, or from 1.0% to 2.0%, by weight of the composition.
  • the buffer system can comprise citric acid and a sodium citrate salt (e.g., trisodium citrate, disodium citrate, or monosodium citrate),
  • a sodium citrate salt e.g., trisodium citrate, disodium citrate, or monosodium citrate
  • composition can further comprise an abrasive, for example, silica abrasives, calcium abrasives, and other abrasives as disclosed herein.
  • an abrasive for example, silica abrasives, calcium abrasives, and other abrasives as disclosed herein.
  • composition can further comprise one or more humectants, as described herein, e.g., selected from sorbitol, glycerol, xylitol and propylene glycol, or combinations thereof.
  • humectants as described herein, e.g., selected from sorbitol, glycerol, xylitol and propylene glycol, or combinations thereof.
  • composition can further comprise one or more surfactants, as described herein, e.g., sodium lauryl sulfate, sodium laureth sulfate, or cocamidopropyl betaine, or combinations thereof.
  • surfactants e.g., sodium lauryl sulfate, sodium laureth sulfate, or cocamidopropyl betaine, or combinations thereof.
  • composition can further comprise an effective amount of one or more alkali phosphate salts for example orthophosphates, pyrophosphates, tripolyphosphates, tetraphosphates or higher polyphosphates.
  • alkali phosphate salts for example orthophosphates, pyrophosphates, tripolyphosphates, tetraphosphates or higher polyphosphates.
  • the alkali phosphate salts can comprise tetrasodium pyrophosphate or tetrapotassium pyrophosphate, for example, in an amount of 0.5 to 5% by weight of the composition, e.g., 1-3%, or 1-2% or about 2% by weight.
  • the alkali phosphate salts can comprise sodium tripolyphosphate or potassium tripolyphosphate, for example, in an amount of 0.5 to 6% by weight of the composition, e.g., 1-4%, or 2-3% or about 3% by weight.
  • composition can further comprise a whitening agent.
  • the composition can further comprise one or more sources of zinc ions in addition to the zinc phosphate, for example a zinc salt selected from zinc citrate, zinc oxide, zinc lactate, zinc pyrophosphate, zinc sulfate, or zinc chloride.
  • a zinc salt selected from zinc citrate, zinc oxide, zinc lactate, zinc pyrophosphate, zinc sulfate, or zinc chloride.
  • the composition can further comprise one or more fluoride ion sources in addition to the stannous fluoride, for example, a fluoride ion source selected from sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride, ammonium fluoride, and combinations thereof.
  • a fluoride ion source selected from sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride, ammonium fluoride, and combinations thereof.
  • the oral care composition can be a dentifrice, e.g., a toothpaste or oral gel.
  • the pH of the composition can be from 6 to 9, such as from 6.5 to 8, or from 6.5 to 7.5, or about 7.5.
  • the composition can be a single-phase composition (e.g., not a dual-phase composition).
  • the composition does not comprise one or more of zinc oxide, zinc citrate, or zinc lactate.
  • the zinc phosphate is the only zinc ion source.
  • the composition is essentially free or free of phosphates of more than four phosphate groups.
  • the composition is essentially free or free of phosphates of more than three phosphate groups.
  • the composition is essentially free or free of hexametaphosphate salts (e.g., sodium hexametaphosphate).
  • hexametaphosphate salts e.g., sodium hexametaphosphate
  • the composition is free of citric acid and alkali metal citrate salts.
  • the composition is free of any organic acid buffer systems.
  • suitable amounts of zinc phosphate can range from 0.05 to 5% by weight, such as from 0.1 to 4% by weight, or from 0.5 to 3% by weight, or from 0.5 to 2% by weight, or from 0.8 to 1.5% by weight, or from 0.9 to 1.1% by weight, or about 1% by weight, relative to the weight of the oral care composition.
  • zinc phosphate is considered insoluble (e.g., poorly soluble), in water, when placed in formulation, e.g., at acidic or basic pH, zinc phosphate can dissolve sufficiently upon use to provide an effective concentration of zinc ions to the enamel, thereby protecting against erosion, reducing bacterial colonization and biofilm development, and providing enhanced shine to the teeth. It has also been discovered that zinc phosphate in a formulation with a second phosphate source enhances phosphate deposition. As explained in WO2014/088573 , this is all unexpected, in view of the poor solubility of zinc phosphate, and the art-recognized view that it is substantially inert in conditions in the oral cavity, as evidenced by its widespread use in dental cement. At the same time, the formulations containing zinc phosphate do not exhibit the poor taste and mouthfeel, poor fluoride delivery, and poor foaming and cleaning associated with conventional zinc-based oral care products, which use more soluble zinc salts.
  • stannous fluoride as defined in the claims, is employed in combination with the zinc phosphate in the compositions of the present disclosure.
  • the stannous fluoride can be employed in an amount that is effective for providing anti-microbial benefits, such as anti-caries protection and/or anti-gingivitis protection, and/or anti-erosion benefits for protection of tooth enamel.
  • stannous fluoride ranges from 0.01% to 5% by weight, relative to the weight of the oral care composition, for example, from 0.05 to 4% by weight, or from 0.1% to 3% by weight, or from 0.2 to 2% by weight, or from 0.3 to 1% by weight, or from 0.4 to 0.8% by weight, or from 0.4 to 0.6% by weight, or from 0.4 to 0.5% by weight, or about 0.45% by weight (e.g., 0.454%), relative to the total weight of the dentifrice composition.
  • Formulations can include stannous levels, provided by stannous fluoride, ranging for example, from 3,000 ppm to 15,000 ppm (mass fraction) stannous ions in the total composition.
  • the soluble stannous content can range from 0.1 wt % to 0.5 wt %, or more, such as from 0.15 wt % to 0.32 wt %, based on the total weight of the composition.
  • the combination of zinc and stannous ions provides one or more of the following benefits: improved antimicrobial benefits compared to the zinc ions alone; improved control of plaque and/or gingivitis; improved protection against the erosion of tooth enamel.
  • the zinc phosphate acts as a stabilizing agent for the stannous fluoride, so that the stannous fluoride remains in solution in the water.
  • stannous fluoride is generally considered unstable in water due to the hydrolytic and oxidative loss of stannous ions at typical pH ranges employed in oral care compositions. Consequently, stannous fluoride is generally employed in compositions containing no water or low water, or with a chelating agent. Tedious procedures are employed in order to provide stable solutions in which the tendency of the stannous ion to be oxidized or hydrolyzed is inhibited.
  • Applicants have surprisingly found that zinc phosphate and stannous fluoride can be combined together in a single phase formulation and stabilized by the presence of an appropriate organic acid buffer system.
  • basic amino acid is meant the naturally occurring basic amino acids, such as arginine, lysine, and histidine, as well as any basic amino acid having a carboxyl group and an amino group in the molecule, which is water-soluble and provides an aqueous solution with a pH of about 7 or greater.
  • basic amino acids include, but are not limited to, arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutanoic acid, diaminopropionic acid, salts thereof or combinations thereof.
  • the amino acid is arginine (e.g., L-arginine). Any basic amino acid may additionally be present either in free or orally acceptable salt form, or as a combination thereof.
  • the basic amino acid is arginine in orally acceptable salt form, e.g., selected from arginine phosphate, arginine citrate, arginine hydrochloride, arginine carbonate, arginine bicarbonate, or arginine sulfate.
  • the basic amino acid is present in an amount of 0.1 to 10% by weight of the composition (calculated as free base amount), for example, 0.1 to 5%, or 0.5 to 5%, or 1 to 4%, or 1 to 3%, or 2 to 3%, or about 2% or about 2.5% by weight.
  • compositions may optionally comprise additional ingredients suitable for use in oral care compositions.
  • additional ingredients include active agents, such as a fluoride source and/or a phosphate source in addition to zinc phosphate.
  • the compositions may be formulated in a suitable dentifrice base, e.g., comprising abrasives, e.g., silica abrasives, surfactants, foaming agents, vitamins, polymers, enzymes, humectants, thickeners, additional antimicrobial agents, preservatives, flavorings, colorings, and/or combinations thereof.
  • suitable dentifrice bases are known in the art.
  • the compositions may be formulated as a gel (e.g., for use in a tray), chewing gum, lozenge or mint. Examples of suitable additional ingredients that can be employed in the compositions of the present disclosure are discussed in more detail below.
  • compositions of the disclosure include an anionic polymer, which is methyl vinyl ether/maleic anhydride or acid copolymer having a molecular weight (M.W.) of from 30,000 to 1,000,000, such as from 300,000 to 800,000, in an amount of from 1 to 20%, e.g., from 5 to 20%, or from 8 to 15%, or from 10 to 14%, or from 11 to 13%, or about 12%.
  • M.W. molecular weight
  • examples of such further suitable anionic polymers are disclosed in U.S. Pat. Nos. 5,188,821 and 5,192,531 .
  • Suitable anionic polymers include synthetic anionic polymeric polycarboxylates, polyacrylic acids and polyacrylates, polyphosphonic acids, and cross-linked carboxyvinyl copolymers.
  • synthetic anionic polymeric polycarboxylates include 1:4 to 4:1 copolymers of maleic anhydride or acid with another polymerizable ethylenically unsaturated monomer. These copolymers are available for example as Gantrez, e.g., AN 139 (M.W. 500,000), AN 119 (M.W. 250,000) and preferably S-97 Pharmaceutical Grade (M.W. 700,000) available from ISP Technologies, Inc., Bound Brook, N.J. 08805.
  • suitable polymers include those such as the 1:1 copolymers of maleic anhydride with ethyl acrylate, hydroxyethyl methacrylate, N-vinyl-2-pyrollidone, or ethylene, the latter being available for example as Monsanto EMA No. 1103, M.W. 10,000 and EMA Grade 61, and 1:1 copolymers of acrylic acid with methyl or hydroxyethyl methacrylate, methyl or ethyl acrylate, isobutyl vinyl ether or N-vinyl-2-pyrrolidone.
  • Suitable generally are polymerized olefinically or ethylenically unsaturated carboxylic acids containing an activated carbon-to-carbon olefinic double bond and at least one carboxyl group, that is, an acid containing an olefinic double bond which readily functions in polymerization because of its presence in the monomer molecule either in the alpha-beta position with respect to a carboxyl group or as part of a terminal methylene grouping.
  • Such acids are acrylic, methacrylic, ethacrylic, alpha-chloroacrylic, crotonic, beta-acryloxy propionic, sorbic, alpha-chlorsorbic, cinnamic, beta-styrylacrylic, muconic, itaconic, citraconic, mesaconic, glutaconic, aconitic, alpha-phenylacrylic, 2-benzyl acrylic, 2-cyclohexylacrylic, angelic, umbellic, fumaric, maleic acids and anhydrides.
  • Other different olefinic monomers copolymerizable with such carboxylic monomers include vinylacetate, vinyl chloride, dimethyl maleate and the like.
  • Copolymers contain sufficient carboxylic salt groups for water-solubility.
  • a further class of polymeric agents includes a composition containing homopolymers of substituted acrylamides and/or homopolymers of unsaturated sulfonic acids and salts thereof, in particular where polymers are based on unsaturated sulfonic acids selected from acrylamidoalykane sulfonic acids such as 2-acrylamide 2 methylpropane sulfonic acid having a molecular weight of from 1,000 to 2,000,000.
  • Another useful class of polymeric agents includes polyamino acids containing proportions of anionic surface-active amino acids such as aspartic acid, glutamic acid and phosphoserine, e.g. as disclosed in U.S. Pat. No. 4,866,161, issued to Sikes et al.
  • compositions of the disclosure may comprise various other agents that are active to protect and enhance the strength and integrity of the enamel and tooth structure and/or to reduce bacteria and associated tooth decay and/or gum disease or to provide other desired benefits.
  • Effective concentration of the active ingredients used herein will depend on the particular agent and the delivery system used. The concentration will also depend on the exact salt or polymer selected. For example, where the active agent is provided in salt form, the counterion will affect the weight of the salt, so that if the counterion is heavier, more salt by weight will be required to provide the same concentration of active ion in the final product.
  • compositions of the disclosure may contain from 0.1 to 1 wt% of an antibacterial agent, such as about 0.3 wt. %. Any suitable antimicrobial actives can be employed.
  • the oral care compositions can include one or more additional fluoride ion sources, e.g., soluble fluoride salts.
  • additional fluoride ion sources e.g., soluble fluoride salts.
  • fluoride ion-yielding materials can be employed as sources of soluble fluoride in the present compositions. Examples of suitable fluoride ion-yielding materials are found in U.S. Pat. No. 3,535,421, to Briner et al. ; U.S. Pat. No. 4,885,155, to Parran, Jr. et al. and U.S. Pat. No. 3,678,154, to Widder et al.
  • Representative fluoride ion sources include, but are not limited to, sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride, ammonium fluoride, and combinations thereof.
  • the fluoride ion source includes sodium fluoride, sodium monofluorophosphate as well as mixtures thereof.
  • the oral care composition of the disclosure may contain stannous fluoride and any additional source of fluoride ions or fluorine-providing agents in amounts sufficient to supply, in total, from 25 ppm to 25,000 ppm (mass fraction) of fluoride ions, generally at least 500 ppm, e.g., from 500 to 2000 ppm, e.g., from 1000 to 1600 ppm, e.g., about 1450 ppm.
  • the appropriate level of fluoride will depend on the particular application.
  • a toothpaste for general consumer use would typically have from1000 to about 1500 ppm, with pediatric toothpaste having somewhat less.
  • a dentifrice or coating for professional application could have as much as 5,000 or even about 25,000 ppm fluoride.
  • Additional fluoride ion sources may be added to the compositions of the disclosure at a level of from 0.01 wt. % to 10 wt. % in one embodiment or from 0.03 wt. % to 5 wt. %, and in another embodiment from 0.1 wt. % to 1 wt. % by weight of the composition.
  • weights of fluoride salts to provide the appropriate level of fluoride ion will vary based on the weight of the counterion in the salt.
  • compositions of the disclosure can include abrasives.
  • suitable abrasives include silica abrasives, such as standard cleaning silicas, high cleaning silicas or any other suitable abrasive silicas.
  • abrasives that can be used in addition to or in place of the silica abrasives include, for example, a calcium phosphate abrasive, e.g., tricalcium phosphate (Ca 3 (PO 4 ) 2 ), hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 ), or dicalcium phosphate dihydrate (CaHPO 4 ā€¢ 2H 2 O, also sometimes referred to herein as DiCal) or calcium pyrophosphate; calcium carbonate abrasive; or abrasives such as sodium metaphosphate, potassium metaphosphate, aluminum silicate, calcined alumina, bentonite or other siliceous materials, or combinations thereof.
  • a calcium phosphate abrasive e.g., tricalcium phosphate (Ca 3 (PO 4 ) 2 ), hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 ), or dicalcium phosphate dihydrate (Ca
  • Silica abrasive polishing materials useful herein, as well as the other abrasives generally have an average particle size ranging between 0.1 and 30 microns, such as between 5 and 15 microns.
  • the silica abrasives can be from precipitated silica or silica gels, such as the silica xerogels described in U.S. Pat. No. 3,538,230, to Pader et al. and U.S. Pat. No. 3,862,307, to Digiulio .
  • Particular silica xerogels are marketed under the trade name Syloid Ā® by the W. R. Grace & Co., Davison Chemical Division.
  • the precipitated silica materials include those marketed by the J. M. Huber Corp.
  • abrasive materials useful in the practice of the oral care compositions in accordance with the disclosure include silica gels and precipitated amorphous silica having an oil absorption value of less than 100 cc/100 g silica, such as from 45 cc/100 g to 70 cc/100 g silica. Oil absorption values are measured using the ASTA Rub-Out Method D281.
  • the silicas are colloidal particles having an average particle size of from 3 microns to 12 microns, and from 5 to 10 microns.
  • Examples of low oil absorption silica abrasives useful in the practice of the disclosure are marketed under the trade designation Sylodent XWA Ā® by Davison Chemical Division of W.R. Grace & Co., Baltimore, Md. 21203.
  • Sylodent 650 XWA Ā® a silica hydrogel composed of particles of colloidal silica having a water content of 29% by weight averaging from 7 to 10 microns in diameter, and an oil absorption of less than 70 cc/100 g of silica is an example of a low oil absorption silica abrasive useful in the practice of the present disclosure.
  • any suitable amount of silica abrasive can be employed.
  • suitable amounts include 10 wt. % or more dry weight of silica particles, such as from 15 wt. % to 30 wt. % or from 15 wt. % to 25 wt. %, based on the total weight of the composition.
  • the oral care compositions of the disclosure also may include an agent to increase the amount of foam that is produced when the oral cavity is brushed.
  • agents that increase the amount of foam include, but are not limited to polyoxyethylene and certain polymers including, but not limited to, alginate polymers.
  • the polyoxyethylene may increase the amount of foam and the thickness of the foam generated by the oral care compositions of the present disclosure.
  • Polyoxyethylene is also commonly known as polyethylene glycol ("PEGā€) or polyethylene oxide.
  • the polyoxyethylenes suitable for compositions of the present disclosure may have a molecular weight of from 200,000 to 7,000,000. In one embodiment the molecular weight may be from 600,000 to 2,000,000 and in another embodiment from 800,000 to 1,000,000.
  • Polyox Ā® is the trade name for the high molecular weight polyoxyethylene produced by Union Carbide.
  • the foaming agent, e.g., polyoxyethylene
  • the foaming agent may be present in an amount of from 0.1% to 50%, in one embodiment from 0.5% to 20% and in another embodiment from 1% to 10%, or from 2% to 5% by weight of the oral care compositions of the present disclosure.
  • compositions useful in the compositions of the present disclosure may contain anionic surfactants, for example:
  • the anionic surfactants useful herein include the water-soluble salts of alkyl sulfates having from 10 to 18 carbon atoms in the alkyl radical and the water-soluble salts of sulfonated monoglycerides of fatty acids having from 10 to 18 carbon atoms.
  • Sodium lauryl sulfate, sodium lauroyl sarcosinate and sodium coconut monoglyceride sulfonates are examples of anionic surfactants of this type.
  • the anionic surfactant is selected from sodium lauryl sulfate and sodium ether lauryl sulfate.
  • the compositions of the disclosure comprise sodium lauryl sulfate.
  • the anionic surfactant may be present in an amount which is effective, e.g., > 0.01% by weight of the formulation, but not at a concentration which would be irritating to the oral tissue, e.g., ā‡ 10%, and optimal concentrations depend on the particular formulation and the particular surfactant.
  • the anionic surfactant is present in a toothpaste at from 0.3% to 4.5% by weight, e.g., about 1.5%.
  • the compositions of the disclosure may optionally contain mixtures of surfactants, e.g., comprising anionic surfactants and other surfactants that may be anionic, cationic, zwitterionic or nonionic.
  • surfactants are those which are reasonably stable throughout a wide pH range.
  • Surfactants are described more fully, for example, in U.S. Pat. No. 3,959,458, to Agricola et al. ; U.S. Pat. No. 3,937,807, to Haefele ; and U.S. Pat. No. 4,051,234, to Gieske et al.
  • the surfactant or mixtures of compatible surfactants that are included in addition to the anionic surfactants can be present in the compositions of the present disclosure in from 0.1% to 5.0%, in another embodiment from 0.3% to 3.0% and in another embodiment from 0.5% to 2.0% by weight of the total composition. These ranges do not include the anionic surfactant amounts.
  • compositions of the present disclosure include a zwitterionic surfactant, for example a betaine surfactant, for example cocamidopropylbetaine, e.g. in an amount of from 0.1% to 4.5% by weight, e.g. from 0.5 to 2% by weight cocamidopropylbetaine.
  • a zwitterionic surfactant for example a betaine surfactant, for example cocamidopropylbetaine, e.g. in an amount of from 0.1% to 4.5% by weight, e.g. from 0.5 to 2% by weight cocamidopropylbetaine.
  • compositions comprise an anticalculus (tartar control) agent.
  • Suitable anticalculus agents include, without limitation, phosphates and polyphosphates (for example pyrophosphates and tripolyphosphates), polyaminopropanesulfonic acid (AMPS), hexametaphosphate salts, zinc citrate trihydrate, polypeptides, polyolefin sulfonates, polyolefin phosphates, and diphosphonates.
  • the compositions of the disclosure thus may comprise phosphate salts in addition to the zinc phosphate.
  • these salts are alkali phosphate salts, e.g., salts of alkali metal hydroxides or alkaline earth hydroxides, for example, sodium, potassium or calcium salts.
  • Phosphate as used herein encompasses orally acceptable mono- and polyphosphates, for example, P 1-6 phosphates, for example monomeric phosphates such as monobasic, dibasic or tribasic phosphate; and dimeric phosphates such as pyrophosphates; and multimeric phosphates, such as tripolyphosphates, tetraphosphates, hexaphosphates and hexametaphosphates (e.g., sodium hexametaphosphate).
  • the selected phosphate is selected from alkali dibasic phosphate and alkali pyrophosphate salts, e.g., selected from sodium phosphate dibasic, potassium phosphate dibasic, dicalcium phosphate dihydrate, calcium pyrophosphate, tetrasodium pyrophosphate, tetrapotassium pyrophosphate, sodium tripolyphosphate, and mixtures of any of two or more of these.
  • the compositions may comprise tetrasodium pyrophosphate in an amount of from 0.5 to 5% by weight, e.g., 1-3%, or 1-2% or about 2% by weight of the composition.
  • the compositions may comprise a mixture of tetrasodium pyrophosphate (TSPP) and sodium tripolyphosphate (STPP), e.g., in proportions of TSPP at from 0.5 to 5 wt. %, such as from 1 to 2 wt. % and STPP at from 0.5 % to 6 wt. %, such as 1 to 4%, or 2 to 3% by weight of the composition.
  • TSPP tetrasodium pyrophosphate
  • STPP sodium tripolyphosphate
  • Such phosphates are provided in an amount effective to reduce erosion of the enamel, to aid in cleaning the teeth, and/or to reduce tartar buildup on the teeth, for example in an amount of from 0.2 to 20 wt. %, e.g., from 1 to 15 wt. %, by weight of the composition.
  • compositions of the disclosure further comprise an organic acid buffer system, e.g., a buffer system comprising a carboxylic acid and one or more conjugate base salts thereof, for example, alkali metal salts thereof.
  • the acid may be, for example, selected from citric acid, lactic acid, malic acid, maleic acid, fumaric acid, acetic acid, succinic acid, and tartaric acid.
  • the one or more conjugate base salts may be independently selected from sodium and potassium salts, or combinations thereof.
  • the organic acid is citric acid
  • the one or more conjugate base salts comprise monosodium citrate (monobasic), disodium citrate (dibasic), trisodium citrate (tribasic), and combinations thereof.
  • the composition may comprise the organic acid buffer system in any effective amount, for example, in an amount of 0.1 to 5.0% by weight of the composition, measured as the combined amount of organic acid and any conjugate base salts.
  • the composition may comprise the organic acid buffer system in an amount of from 0.5 to 4.0%, or from 1.0 to 3.0%, or from 1.5 to 3.0%, or from 1.0 to 2.4%, or from 1.0% to 2.0%, by weight of the composition.
  • the ratio of acid to conjugate base may be, for example, from 1:1 to 1:10, e.g., from 1:2 to 1:8, or from 1:3 to 1:6, or from 1:4 to 1:6, or from 1:5 to 1:6, or about 1:5, by weight of the components.
  • the ratio of acid to conjugate base may be reversed, e.g., from 1:1 to 10:1, e.g., from 2:1 to 8:1, or from 6:1 to 3:1, or from 4:1 to 6:1 or about 5:1, by weight of the components.
  • the buffer system comprises citric acid and a sodium citrate salt (e.g., trisodium citrate, disodium citrate, or monosodium citrate), in a ratio of from 3:1 to 6:1, or 4:1 to 6:1, or about 4:1 (e.g., about 4.1:1), by weight.
  • a sodium citrate salt e.g., trisodium citrate, disodium citrate, or monosodium citrate
  • the oral care compositions of the disclosure may also include a flavoring agent.
  • Flavoring agents which are used in the practice of the present disclosure include, but are not limited to, essential oils as well as various flavoring aldehydes, esters, alcohols, and similar materials.
  • the essential oils include oils of spearmint, peppermint, wintergreen, sassafras, clove, sage, eucalyptus, marjoram, cinnamon, lemon, lime, grapefruit, and orange. Also useful are such chemicals as menthol, carvone, and anethole. Certain embodiments employ the oils of peppermint and spearmint.
  • the flavoring agent may be incorporated in the oral composition at a concentration of from 0.1 to 5% by weight e.g., from 0.5 to 1.5% by weight.
  • the oral care compositions of the disclosure may also include additional polymers to adjust the viscosity of the formulation or enhance the solubility of other ingredients.
  • additional polymers include polyethylene glycols, polysaccharides (e.g., cellulose derivatives, for example carboxymethyl cellulose, hydroxymethyl cellulose, ethyl cellulose, microcrystalline cellulose or polysaccharide gums, for example xanthan gum, guar gum or carrageenan gum).
  • Acidic polymers, for example polyacrylate gels may be provided in the form of their free acids or partially or fully neutralized water soluble alkali metal (e.g., potassium and sodium) or ammonium salts.
  • the oral care composition may contain PVP.
  • PVP generally refers to a polymer containing vinylpyrrolidone (also referred to as N-vinylpyrrolidone, N-vinyl-2-pyrrolidione and N-vinyl-2-pyrrolidinone) as a monomeric unit.
  • the monomeric unit consists of a polar imide group, four non-polar methylene groups and a non-polar methane group.
  • compositions of the disclosure comprise one or more polyethylene glycols, for example, polyethylene glycols in a molecular weight range from 200 to 800.
  • the compositions may comprise one or more of polyethylene glycol 200, polyethylene glycol 300, polyethylene glycol 400, polyethylene glycol, 600 or polyethylene glycol 800.
  • Silica thickeners which form polymeric structures or gels in aqueous media, may be present. Note that these silica thickeners are physically and functionally distinct from the particulate silica abrasives also present in the compositions, as the silica thickeners are very finely divided and provide little or no abrasive action.
  • Other thickening agents are carboxyvinyl polymers, carrageenan, hydroxyethyl cellulose and water soluble salts of cellulose ethers such as sodium carboxymethyl cellulose and sodium carboxymethyl hydroxyethyl cellulose. Natural gums such as karaya, gum arabic, and gum tragacanth can also be incorporated. Colloidal magnesium aluminum silicate can also be used as component of the thickening composition to further improve the composition's texture.
  • thickening agents in an amount of from 0.5% to 5.0% by weight of the total composition are used.
  • Humectants Within certain embodiments of the oral compositions, it is also desirable to incorporate a humectant to prevent the composition from hardening upon exposure to air. Certain humectants can also impart desirable sweetness or flavor to dentifrice compositions. Suitable humectants include edible polyhydric alcohols such as glycerin, sorbitol, xylitol, propylene glycol as well as other polyols and mixtures of these humectants. In one embodiment of the disclosure, the principal humectant is one of glycerin, sorbitol or a combination thereof. The humectant may be present at levels of greater than 15 wt. %, such as from 15 wt.
  • % to 55 wt. % or from 20 wt. % to 50 wt. %, or from 20 wt. % to 40 wt. %, or about 20% or about 30% or about 40%, based on the total weight of the composition.
  • Optional ingredients include, for example, but are not limited to, adhesives, sudsing agents, flavoring agents, sweetening agents such as sodium saccharin, additional antiplaque agents, abrasives, aesthetics such as TiO 2 coated mica or other coloring agents, such as dyes and/or pigments.
  • compositions of the present disclosure can have any pH suitable for in a product for use in oral care.
  • suitable pH ranges are from 6 to 9, such as from 6.5 to 8, or 6.5 to 7.5, or about 7.0.
  • the oral care compositions of the present disclosure are either essentially free of, free of, or do not include any sodium hexametaphosphate. In some embodiments, the oral care compositions of the present disclosure are either essentially free of, free of, or do not include any halogenated diphenyl ethers (e.g., triclosan).
  • compositions have no more than 0.01% by weight of these compounds.
  • compositions of the present disclosure are either essentially free of, free of or do not include any complexing agents for increasing solubility of zinc phosphate and/or for maintaining the stannous fluoride in solution.
  • complexing agents for increasing solubility of zinc phosphate and/or for maintaining the stannous fluoride in solution.
  • known complexing agents include the chelating agents taught in U.S. Patent Application No. 2007/0025928 .
  • Such chelating agents include mineral surface-active agents, including mineral surface-active agents that are polymeric and/or polyelectrolytes and that are selected from phosphorylated polymers, wherein if the phosphorylated polymer is a polyphosphate, the polyphosphate has average chain length of 3.5 or more, such as 4 or more; polyphosphonates; copolymers of phosphate- or phosphonate-containing monomers or polymers with ethylenically unsaturated monomers, amino acids, proteins, polypeptides, polysaccharides, poly(acrylate), poly(acrylamide), poly(methacrylate), poly(ethacrylate), poly(hydroxyalkylmethacrylate), poly(vinyl alcohol), poly(maleic anhydride), poly(maleate) poly(amide), polyethylene amine), poly(ethylene glycol), polypropylene glycol), poly(vinyl acetate) and poly(vinyl benzyl chloride); and mixtures thereof.
  • Other known complexing agents that can be excluded from the
  • Examples include polyphosphorylated inositol compounds such as phytic acid, myo-inositol pentakis(dihydrogen phosphate); myo-inositol tetrakis(dihydrogen phosphate), myo-inositol trikis(dihydrogen phosphate), and alkali metal, alkaline earth metal or ammonium salts of any of the above inositol compounds.
  • Phytic acid is also known as myo-inositol 1,2,3,4,5,6-hexakis (dihydrogen phosphate) or inositol hexaphosphoric acid.
  • the present disclosure provides a method of treatment or prevention of erosive tooth demineralization, gingivitis, plaque, and/or dental caries, the method comprising the application to the oral cavity of a person in need thereof a composition according to the invention (e.g., Composition 1.0 et seq ), e.g., by brushing, for example, one or more times per day.
  • a composition according to the invention e.g., Composition 1.0 et seq
  • the present disclosure provides a method of using the compositions described herein (e.g., any of Compositions 1.0 et seq ) to increase zinc levels in the enamel and to treat, reduce or control the incidence of enamel erosion.
  • the methods comprise applying any of the compositions as described herein to the teeth, e.g., by brushing, or otherwise administering the compositions to the oral cavity of a subject in need thereof.
  • the compositions can be administered regularly, such as, for example, one or more times per day.
  • administering the compositions of the present disclosure to a patient can provide one or more of the following benefits: (i) reduce hypersensitivity of the teeth, (ii) reduce plaque accumulation, (iii) reduce or inhibit demineralization and promote remineralization of the teeth, (iv) inhibit microbial biofilm formation in the oral cavity, (v) reduce or inhibit gingivitis, (vi) promote healing of sores or cuts in the mouth, (vii) reduce levels of acid producing bacteria, (viii) increase relative levels of non-cariogenic and/or non-plaque forming bacteria, (ix) reduce or inhibit formation of dental caries, (x) reduce, repair or inhibit pre-carious lesions of the enamel, e.g., as detected by quantitative light-induced fluorescence (QLF) or electrical caries measurement (ECM), (xi) treat, relieve or reduce dry mouth, (xii) clean the teeth and oral cavity, (xiii) reduce erosion, (xiv) whiten teeth; (xv) reduce tartar build-
  • QLF
  • the present application further discloses a method of making any of the compositions of the present disclosure.
  • the method comprises combining zinc phosphate and stannous fluoride in water to form an aqueous zinc phosphate mixture.
  • the zinc phosphate is added to the dentifrice composition as a preformed salt and remains essentially insoluble in the aqueous mixture.
  • the amount of water employed in the mixture can be any of the amounts recited herein for the compositions of the present disclosure.
  • Any standard mixing techniques can be employed to combine the ingredients and form a stable composition without the need for additional complexing agents to solubilize the stannous fluoride, such as any of the above disclosed complexing or chelating agents, or the use of anhydrous mixing techniques such as dissolving stannous fluoride in an anhydrous material such as glycerin.
  • Dentifrice Formulations according to the present disclosure are prepared according to Table 1 below: Table 1 Ingredient Weight % Water Q.S. Humectants 15-55 Abrasives 10-30 Thickeners 0.5-5 Anionic Polymer 1-20 Zinc Phosphate 0.05-5 Flavor, Sweetener, Colors 0.5-5 Alkali Phosphate Salts 0.5-5 Anionic Surfactant 0.01-10 Zwitterionic Surfactant 0.1-4.5 Organic Acid Buffer Acid (e.g. Citric Acid) 0.0 - 3.0 Stannous Fluoride 0.5-11 Basic amino acid (e.g., arginine) 0.1-10%

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Claims (9)

  1. Composition de soins bucco-dentaires Ć  haute teneur en eau comprenant
    un support oralement acceptable comprenant en outre de l'eau, dans lequel la quantitƩ de l'eau est de 10 Ơ 99 % en poids, par rapport au poids de la composition de soins bucco-dentaires,
    du phosphate de zinc, prƩsent en une quantitƩ de 0,05 Ơ 10 % en poids, par rapport au poids de la composition de soins bucco-dentaires,
    du fluorure stanneux, de 0,01 % Ć  5 % en poids, par rapport au poids de la composition de soins bucco-dentaires,
    un polymĆØre anionique, dans lequel le polymĆØre anionique est un copolymĆØre d'Ć©ther mĆ©thylvinylique/anhydride ou acide malĆ©ique ayant un poids molĆ©culaire moyen (M.W.) d'environ 30 000 Ć  environ 1 000 000, et
    un acide aminƩ basique, dans lequel l'acide aminƩ est l'arginine et dans lequel l'acide aminƩ basique est prƩsent en une quantitƩ de 0,1 Ơ 10 % en poids de la composition, calculƩe comme la quantitƩ de la base libre.
  2. Composition selon la revendication 1, dans laquelle l'acide aminƩ basique est l'arginine, par ex. la L-arginine, sous forme libre ou de sel oralement acceptable, par exemple le phosphate d'arginine, le citrate d'arginine, le chlorhydrate d'arginine, le carbonate d'arginine, le bicarbonate d'arginine ou le sulfate d'arginine.
  3. Composition selon l'une quelconque des revendications prĆ©cĆ©dentes, dans laquelle le polymĆØre anionique est choisi dans le groupe constituĆ© par les polycarboxylates polymĆØres anioniques synthĆ©tiques, les acides polyacryliques, les acides polyphosphoniques et les copolymĆØres carboxyvinyliques rĆ©ticulĆ©s.
  4. Composition selon l'une quelconque des revendications prĆ©cĆ©dentes, dans laquelle le polymĆØre anionique est prĆ©sent en une quantitĆ© de 1 Ć  20 % en poids de la composition.
  5. Composition selon l'une quelconque des revendications prƩcƩdentes, comprenant en outre un ou plusieurs humectants et/ou tensioactifs.
  6. Composition selon l'une quelconque des revendications prƩcƩdentes, comprenant en outre une quantitƩ efficace d'un ou de plusieurs sels de phosphate alcalin.
  7. Composition selon la revendication 6, dans laquelle les sels de phosphate alcalin comprennent le pyrophosphate tƩtrasodique ou le pyrophosphate tƩtrapotassique.
  8. Composition selon l'une quelconque des revendications prƩcƩdentes, dans laquelle la composition de soins bucco-dentaires est un dentifrice.
  9. Composition selon l'une quelconque des revendications prƩcƩdentes pour une utilisation dans une mƩthode de traitement ou de prƩvention de la dƩminƩralisation dentaire Ʃrosive, de la gingivite, de la plaque et/ou des caries dentaires, la mƩthode comprenant l'application de la composition Ơ la cavitƩ buccale d'une personne en ayant besoin.
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US6685920B2 (en) 1999-11-12 2004-02-03 The Procter & Gamble Company Method of protecting teeth against erosion
US20070025928A1 (en) 1999-11-12 2007-02-01 The Procter & Gamble Company Stannous oral care compositions
JP2009520829A (ja) 2005-12-20 2009-05-28 悶 惗惭ć‚Æć‚æćƒ¼ ć‚¢ćƒ³ćƒ‰ ć‚®ćƒ£ćƒ³ćƒ–ćƒ« ć‚«ćƒ³ćƒ‘ćƒ‹ćƒ¼ äŗœé‰›ćŠć‚ˆć³ćƒ•ć‚£ćƒćƒ³é…øå”©ć‚’å«ć‚€å£č…”ć‚±ć‚¢ēµ„ęˆē‰©
US20130224270A1 (en) * 2010-10-27 2013-08-29 Colgate-Palmolive Company Oral Care Composition Comprising Arginine and Calcium Carbonate
MX345131B (es) * 2010-11-04 2017-01-17 Colgate Palmolive Co Composicion dentifrica con astringencia reducida.
MY162550A (en) 2011-02-15 2017-06-15 Colgate Palmolive Co Taste-masked oral care compositions
KR20150092255A (ko) 2012-12-05 2015-08-12 ģ½œź²Œģ“ķŠø-ķŒŒģ•„ėƀģ˜¬ė¦¬ėøŒģŗ„ķŒŒė‹ˆ ķ”Œė£Øģ˜¤ė¼ģ“ė“œ-ģ•ˆģ • ģ•„ģ—°ģ„ ķ•Øģœ ķ•˜ėŠ” ģ”°ģ„±ė¬¼
IN2015DN03992A (fr) * 2012-12-05 2015-10-02 Colgate Palmolive Co
US20160324741A1 (en) * 2013-06-10 2016-11-10 The Procter & Gamble Company Oral Compositions Containing Zinc
WO2015131002A1 (fr) * 2014-02-27 2015-09-03 The Procter & Gamble Company Compositions de soins bucco-dentaires dont l'amertume perƧue est rƩduite
CA2952921C (fr) 2014-06-20 2021-06-15 Colgate-Palmolive Company Compositions orales contenant des sources d'ions de zinc, fluorures et stanneux
EP3177264B1 (fr) 2014-08-08 2020-07-22 Colgate-Palmolive Company Ɖlimination et prĆ©vention des taches dentaires
CN109310592B (zh) 2016-06-24 2022-02-25 é«˜éœ²ę“-ę£•ę¦„å…¬åø å£č…”ęŠ¤ē†ē»„合ē‰©
US10278906B2 (en) 2016-06-24 2019-05-07 Colgate-Palmolive Company Oral care compositions
CN114732748A (zh) 2016-06-24 2022-07-12 é«˜éœ²ę“-ę£•ę¦„å…¬åø å£č…”ęŠ¤ē†ē»„合ē‰©å’Œä½æē”ØčÆ„ē»„合ē‰©ēš„ę–¹ę³•
AU2017379608B2 (en) 2016-12-21 2019-10-10 Colgate-Palmolive Company Oral care compositions
US10646420B2 (en) 2016-12-21 2020-05-12 Colgate-Palmolive Company Oral care compositions and methods of use
US10172770B2 (en) 2016-12-21 2019-01-08 Colgate-Palmolive Company Oral care compositions

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US20200121572A1 (en) 2020-04-23
RU2739381C1 (ru) 2020-12-23
BR112019012120B1 (pt) 2022-03-22
EP4241757A3 (fr) 2023-11-08
BR112019012120A2 (pt) 2019-11-05
AU2017379612A1 (en) 2019-07-04
EP3541350A1 (fr) 2019-09-25
CN110087618A (zh) 2019-08-02
MX2021006838A (es) 2022-08-23
CA3044406A1 (fr) 2018-06-28
MX2019007359A (es) 2019-09-05
US11806417B2 (en) 2023-11-07
EP4241757A2 (fr) 2023-09-13
ZA201903451B (en) 2022-12-21
WO2018118142A1 (fr) 2018-06-28
US11234912B2 (en) 2022-02-01
US20220125694A1 (en) 2022-04-28
US20200368126A1 (en) 2020-11-26
AU2017379612B2 (en) 2020-02-20
US20180168963A1 (en) 2018-06-21
US10772810B2 (en) 2020-09-15

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