EP3519781B1 - Tête de distribution pour pompe d'aspiration - Google Patents

Tête de distribution pour pompe d'aspiration Download PDF

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Publication number
EP3519781B1
EP3519781B1 EP17739875.7A EP17739875A EP3519781B1 EP 3519781 B1 EP3519781 B1 EP 3519781B1 EP 17739875 A EP17739875 A EP 17739875A EP 3519781 B1 EP3519781 B1 EP 3519781B1
Authority
EP
European Patent Office
Prior art keywords
distributor head
hollow needles
housing
head according
pipetting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP17739875.7A
Other languages
German (de)
English (en)
Other versions
EP3519781A1 (fr
Inventor
Jonas Bode
Malte Ständer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sartorius Lab Instruments GmbH and Co KG
Original Assignee
Sartorius Lab Instruments GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sartorius Lab Instruments GmbH and Co KG filed Critical Sartorius Lab Instruments GmbH and Co KG
Publication of EP3519781A1 publication Critical patent/EP3519781A1/fr
Application granted granted Critical
Publication of EP3519781B1 publication Critical patent/EP3519781B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B39/00—Component parts, details, or accessories, of pumps or pumping systems specially adapted for elastic fluids, not otherwise provided for in, or of interest apart from, groups F04B25/00 - F04B37/00
    • F04B39/08—Actuation of distribution members
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01G—WEIGHING
    • G01G17/00—Apparatus for or methods of weighing material of special form or property
    • G01G17/04—Apparatus for or methods of weighing material of special form or property for weighing fluids, e.g. gases, pastes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/1407—Infusion of two or more substances
    • A61M5/1408—Infusion of two or more substances in parallel, e.g. manifolds, sequencing valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B39/00—Component parts, details, or accessories, of pumps or pumping systems specially adapted for elastic fluids, not otherwise provided for in, or of interest apart from, groups F04B25/00 - F04B37/00
    • F04B39/10—Adaptations or arrangements of distribution members
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • G01N35/085—Flow Injection Analysis

Definitions

  • Such suction pumps typically comprise a single pumping station which generates the required negative pressure and which is connected to the pump connection of a generic distributor head.
  • the distributor head has a plurality of hollow needles fixed on its housing, the arrangement and orientation of which are adapted to those of the pipetting vessels of the gravimetric test device.
  • the individual hollow needles are connected to the pump connection in a liquid-tight manner.
  • a main line is usually connected to the pump connection, from which individual branch lines branch off to the individual hollow needles.
  • the distributor head is positioned in such a way that all hollow needles are immersed in the pipetting vessels to the desired depth.
  • the negative pressure generated by the pumping station is then distributed to all suction channels so that the liquid is sucked out of all pipetting vessels in parallel.
  • the switching valve assigned to each individual channel makes it possible to block the individual channels individually and independently of one another. If one of the pipetting vessels is emptied prematurely and its associated hollow needle draws air, the corresponding suction channel can be closed so that the negative pressure generated by the pumping station is only distributed over the remaining, open channels, whose associated vessels are consequently further emptied by suction. Thus, by successively switching off each air-drawing channel, the even emptying of all vessels, i.e. their emptying to the same residual level (which of course also includes the complete evacuation) can be ensured.
  • each switching valve is assigned a test chamber, the interior of which is part of the respective connection path and the outer wall of which includes a viewing window penetrating the housing. As soon as a duct draws in air, bubbles appear in it and migrate towards the pumping station. They also pass through the test chamber, which the user can detect from the outside through the viewing window. Through the given assignment of each viewing window to a special switching valve, the switching valve to be switched to switch off the channel can be easily identified.
  • the test chambers are arranged on the hollow needle side of the respectively assigned switching valve in the respective connection path. It has been found that the switching valves - at least in the closed state - act as insulators for the rapid pressure fluctuations generated by the pumping station and continuing in the connecting paths. These cause air bubbles in the test chamber to shake that can be seen through the viewing window. Due to the arrangement of the test chambers on the hollow needle side, a channel with a valve that is already closed (after drawing air) can be clearly differentiated from one with an open valve based on the resting or trembling of the air bubble.
  • valves should be open at the beginning of every suction process. This is the only way to ensure that all vessels are aspirated. If a valve that was individually closed during a previous suction process remains closed inadvertently during the next suction process, undesired overflows can occur during subsequent pipetting processes. In the context of the electronics-based automation mentioned above, it is unproblematic to ensure this using programming technology. In order to also make purely manually operated embodiments immune to errors, a development of the invention provides that the switching valves are designed as negative pressure-sensitive normally open valves. The person skilled in the art generally designates a normally open valve as a valve which is open in the non-actuated state.
  • Unactuated can refer to a non-existent mechanical actuation as well as a lack of current supply to an electrical valve.
  • “Vacuum-sensitive” in this context means that the non-actuated, ie open, state of the valve is automatically set when there is no vacuum at the valve. The skilled person are various ways known to realize this both with electrical and purely mechanical valves.
  • the housing is connected via two telescopic rods 20 to a positioning plate 22 which can be precisely positioned on a gravimetric test device (not shown) for multi-channel pipettes.
  • the positional accuracy is ensured via form-fit contours 24, which find corresponding contours on the test device.
  • the positioning plate 22 is positioned on the test device in such a way that the hollow needles 18 are positioned exactly over the pipetting vessels to be aspirated.
  • the immersion depth can be determined by an in Figure 1 adjustable stop not shown in detail.
  • the line arrangement 14 comprises a main line 32 from which a branch line 34 branches off for each hollow needle 18.
  • the branch lines 34 each pass a switching valve 36 designed as a negative pressure-sensitive normally open valve and open into the hollow needles 18.
  • a test chamber 38 is arranged in each branch line 34, one chamber wall of which is designed as a viewing window 40 in the cover of the housing 12 .
  • the pump station 28 After positioning the hollow needles 18 in the pipetting vessels to be aspirated, the pump station 28 is switched on. Liquid is pumped from the pipetting vessels into the tank 30 through the open valves 36. If the liquid level in a pipetting device falls below the free end of the associated hollow needle 18, this hollow needle draws air. Correspondingly, bubbles form in the test chamber 38, which can be detected by the user through the corresponding viewing window 40. In Figure 1 such bubbles are shown in the third window from the left. In order to enable further suction of the remaining pipetting vessels, the corresponding branch line 34 can be blocked by means of a switch 42 which is assigned to each switching valve 36.
  • the line system 14 then no longer draws any air, so that liquid continues to flow out the pipetting vessels is sucked off until the liquid level of another vessel falls below the tip of the associated hollow needle 18.
  • the third switch 42 from the left is assigned to the test chamber 38, which can be viewed from the left by means of the third viewing window 40, and is shown in the already actuated position.
  • the six visible switches 42 are assigned to the six left hollow needles 18, whereas the switching valves 34 assigned to the six right hollow needles 18 are operated by switches on the opposite side of the housing, which is not visible.

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • General Physics & Mathematics (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Claims (6)

  1. Tête de distribution pour une pompe d'aspiration, comprenant
    - un boîtier (12),
    - un raccord de pompe (16) pour l'application d'une pression négative et
    - une pluralité d'aiguilles creuses (18) reliées au raccord de pompe (16) de manière étanche au fluide et disposées à distance les unes des autre,
    dans laquelle les différents trajets de liaison (34) des aiguilles creuses (18) au raccord de pompe (16) présentent respectivement une soupape de commande (36) pouvant être actionnée de façon indépendante,
    caractérisée en ce
    que les aiguilles creuses (18) sont fixées sur le boîtier (12) et sont disposées parallèlement les unes aux autres et une chambre de contrôle (38), dont l'espace intérieur fait partie du trajet de liaison (34) respectif et dont la paroi extérieure comprend une fenêtre d'inspection (40) traversant le boîtier (12), est associée à chaque soupape de commande (36),
    dans laquelle les chambres de contrôle (38) sont disposées dans le trajet de liaison (34) respectif côté aiguille creuse de la soupape de commande (36) respectivement associée.
  2. Tête de distribution selon la revendication 1,
    caractérisée en ce
    que les aiguilles creuses peuvent être alignées individuellement dans leur position en hauteur.
  3. Tête de distribution selon l'une quelconque des revendications précédentes,
    caractérisée en ce
    que les soupapes de commande (36) sont réalisées sous la forme de soupapes normalement ouvertes sensibles à la pression négative.
  4. Tête de distribution selon l'une quelconque des revendications précédentes,
    caractérisée en ce
    qu'elle peut se déplacer de manière guidée au moyen d'au moins une tige télescopique (20) disposée sur le boîtier (12) parallèlement aux aiguilles creuses (18).
  5. Tête de distribution selon la revendication 4,
    caractérisée en ce
    qu'elle présente une butée réglable, délimitant son parcours de déplacement.
  6. Tête de distribution selon l'une quelconque des revendications 4 à 5,
    caractérisée en ce
    que la tige télescopique (20) comprend un mécanisme d'amortissement.
EP17739875.7A 2016-09-27 2017-07-14 Tête de distribution pour pompe d'aspiration Active EP3519781B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102016118183.8A DE102016118183B3 (de) 2016-09-27 2016-09-27 Verteilerkopf für eine Saugpumpe
PCT/EP2017/000848 WO2018059723A1 (fr) 2016-09-27 2017-07-14 Tête de distribution pour pompe d'aspiration

Publications (2)

Publication Number Publication Date
EP3519781A1 EP3519781A1 (fr) 2019-08-07
EP3519781B1 true EP3519781B1 (fr) 2020-11-18

Family

ID=59350862

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17739875.7A Active EP3519781B1 (fr) 2016-09-27 2017-07-14 Tête de distribution pour pompe d'aspiration

Country Status (4)

Country Link
US (1) US10704543B2 (fr)
EP (1) EP3519781B1 (fr)
DE (1) DE102016118183B3 (fr)
WO (1) WO2018059723A1 (fr)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3239567C2 (de) * 1982-10-26 1986-10-16 Schwartauer Werke Gmbh & Co, 2407 Bad Schwartau Vorrichtung zum Sortieren von Trockenfrüchten
WO1988000347A1 (fr) * 1986-07-01 1988-01-14 Biotech Instruments Limited Installation d'analyse chimique automatique
US5915414A (en) * 1997-09-04 1999-06-29 Lsi Logic Corporation Standardized gas isolation box (GIB) installation
DE29917940U1 (de) * 1999-10-12 2000-01-05 Fraunhofer Ges Forschung Vorrichtung zur gravimetrischen Prüfung von Mehrkanalpipetten
US6637476B2 (en) * 2002-04-01 2003-10-28 Protedyne Corporation Robotically manipulable sample handling tool
EP1698872B1 (fr) * 2005-03-02 2007-10-10 Mettler-Toledo AG Dispositif pour peser des produits homogènes
US7644725B2 (en) * 2005-12-16 2010-01-12 Advance Electric Japan Kabushiki Kaisha Mixing valve and mixing device
DE102013207081B4 (de) * 2013-01-25 2019-10-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Prüfvorrichtung zum gravimetrischen Prüfen von Mehrkanalpipetten

Also Published As

Publication number Publication date
WO2018059723A1 (fr) 2018-04-05
EP3519781A1 (fr) 2019-08-07
DE102016118183B3 (de) 2017-11-16
US20190219045A1 (en) 2019-07-18
US10704543B2 (en) 2020-07-07

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