EP2806973B1 - Dispositif et methode de dosage d'un liquide - Google Patents

Dispositif et methode de dosage d'un liquide Download PDF

Info

Publication number
EP2806973B1
EP2806973B1 EP13704546.4A EP13704546A EP2806973B1 EP 2806973 B1 EP2806973 B1 EP 2806973B1 EP 13704546 A EP13704546 A EP 13704546A EP 2806973 B1 EP2806973 B1 EP 2806973B1
Authority
EP
European Patent Office
Prior art keywords
liquid
pressure
draining
liquid container
cavity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP13704546.4A
Other languages
German (de)
English (en)
Other versions
EP2806973A1 (fr
Inventor
Robert BEIKLER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PVA TePla AG
Original Assignee
PVA TePla AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PVA TePla AG filed Critical PVA TePla AG
Publication of EP2806973A1 publication Critical patent/EP2806973A1/fr
Application granted granted Critical
Publication of EP2806973B1 publication Critical patent/EP2806973B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/146—Employing pressure sensors

Definitions

  • the present application relates to a device and a method for dosing liquids.
  • a metering device for fluids is from the DE 35 31 241 C2 known.
  • liquid is forced through a cannula with the aid of a pressure transducer.
  • a pressure sensor measures the pressure of the liquid in the cannula, the measurement result is fed to a control device for controlling the pressure transducer.
  • trapped air in the liquid but can not close exactly from the pressure curve on the discharged amount of liquid. This is problematic in dosing operations where the exact dosage of small amounts is important.
  • the document EP 0 865 824 A1 shows a device for dosing a liquid and a pressure measurement within a sample space.
  • US 2008/015406 A1 shows a syringe with an intermediate pressure sensor.
  • a device for dosing liquids with a liquid container, a discharge device and a pressure measuring device having a cavity and a pressure sensor for detecting a pressure in the cavity.
  • a first tube device is configured to direct liquid from the liquid container through the interior of the first tube device to the cavity and a second tube device to direct liquid from the cavity through the interior of the second tube device to the discharge device.
  • the device is set up such that all liquid flowing from the liquid container to the discharge device flows through the cavity.
  • a tube device may include tubing or tubing or a combination of tubing or tubing and may also include valves and complex branches.
  • the two paths, one to and one from the cavity, have the advantage that the cavity can be flushed by allowing liquid to flow through the cavity from one path and liquid from the cavity through the other path.
  • Air bubbles have the disadvantage that from the measured pressure difference can not be reliably determined on the amount of discharged liquid.
  • gas must not be dosed, otherwise the target volume is not maintained.
  • Air and other gases are usually compressible, so that pressure changes initially cause a deformation of the gas bubbles. Holes in tube devices that are not flushed carry the risk of air bubbles accumulating in them. This is particularly critical for metering devices with very high accuracy requirements.
  • the structure of the device should therefore be as simple as possible, the surfaces through which the liquid flows, be as smooth as possible. There should be no or the smallest possible dead volumes for the liquid.
  • the structure should be robust, reliable and safe, so that repeatable without correction by users, for example, for days or weeks, can be dosed. Thus, there is an excellent suitability for automation.
  • the device can also be used to set a period of time in which liquid is conveyed from the liquid container into the tube device. From the multiplication of the time period times the volume drained by the discharge device per time, the total drained volume can be determined. However, this determination is only correct if there are no air bubbles in the tube system. The presence of air bubbles can at least be detected with the device according to the application. If air bubbles were detected during the dosing process, the metered quantity can be destroyed and the dosing process repeated. Thus, ultra-accurate metering operations can be carried out with the device according to the application.
  • the device can thus also be used in particular in mixing processes in which ultra-purity is important, and in particular in mixing processes in which ultra-aggressive fluids are used.
  • the device according to the application can also be referred to as a form of liquid handling monitoring.
  • the liquid container is filled with liquid.
  • a gas cushion is fundamentally compressible and therefore makes it more difficult to control the discharge based on the measured pressure.
  • a gas cushion increases the risk of gas bubbles entering the liquid.
  • Gas cushions or separation gaps require mechanical. moving brackets or injectors. This results in high costs, space requirements and contamination sources. Separation gaps are gas bubbles that are located above the liquid to be dispensed.
  • the first tube device includes a tube that opens into the cavity.
  • This hose can be flexibly guided by the pressure measuring device and thus be guided directly into the cavity as simply as possible. This simplifies the assembly of the device.
  • the device when the discharge device has a downwardly open tip with an opening cross-section of less than 0.4 mmm is particularly suitable.
  • the small orifice cross-section provides a high resistance to the liquid so that the pressure in the tube device becomes relatively high even at low dosing speed, and provides a small interface between the liquid and the air at the vent, which improves the accuracy of dosing elevated.
  • the pressure difference between the state in which the device is at rest, and a state in which the device discharges liquid is thus relatively high, with which high-precision monitoring and measurements are possible.
  • the draining device has no moving parts, the number of components in the device is reduced because each additional component contains other materials that could cause soiling. For complex systems, the space requirement would be enormous, they would then not be feasible with reasonable effort.
  • a switch is provided between the tube device and the pressure measuring device, by means of which the paths are spatially separated from one another be separated. This switch allows for easy separation between the paths so that they can easily be connected to the different ports of the switch to allow flushing of the cavity.
  • the pressure sensor includes a piezoelectric element. With such a pressure changes can be easily converted into electrical signals.
  • the detected signals are interpreted electronically in an evaluation unit and error messages are output according to the signal curves, it is possible to output warnings and to send them to an operator without having to constantly observe the signal progressions.
  • the evaluation preferably takes place with the aid of a Fourier transformation. With such a complex signal waveforms can be interpreted quickly, so that a quick error message is possible. This allows an operator to intervene immediately when needed.
  • a pressure-increasing device for example a piston that is hydraulically driven, is provided to increase the pressure in the fluid. With such a dosing speed can be increased.
  • the pressure-increasing device may also include means for increasing the gas pressure in a cylinder containing the liquid and a gas.
  • liquid can be drained without having to move moving parts in the path between the liquid container and the discharge device during draining, as would be the case with conventional outlet valves.
  • the number of components can be reduced, which reduces the space required and the
  • a multi-way valve is provided at the end of the first tube device, so that it is possible to switch over between a plurality of second tube devices, each of which opens into its own outlet device.
  • a multi-way valve is not switched while being drained. This allows a good control of the process by means of a pressure measurement during the discharge process.
  • the step of increasing the pressure is performed at least twice, wherein in a first pass the first tube device and the second tube device are flushed and in a second passage a predetermined amount of liquid is metered out.
  • the application also relates to a method for dosing liquid in a container with a device according to the application.
  • the method includes a step of applying a pressure to the liquid to drain the liquid.
  • the pressure is measured by the pressure sensor and the measured pressure is shown on the display.
  • the device can be monitored for increased pressures. If these pressures become too great, there is a risk of bursting tubes or hoses. Especially at aggressive and toxic media such as hydrofluoric acid end up bursting hoses surrounding people. Thus, with the method, the safety can be increased.
  • a step of venting the liquid is made prior to the step of applying pressure to the liquid.
  • a step of venting the liquid is made prior to the step of applying pressure to the liquid.
  • a lot of liquid is drained off before the actual dosing process.
  • liquids are metered into a container, a device according to the application being used.
  • the method comprises a step of exerting pressure on the liquid for discharging the liquid, the pressure being measured by the pressure sensor and the measured pressure being examined for defect images by means of an electronic evaluation.
  • the automatic electronic evaluation is provided so that an operator gets the errors reported, for example by short message (SMS) on his mobile phone.
  • SMS short message
  • the application also relates to a method of dosing liquids with a device including a liquid container completely filled with liquid, a discharge device and a tube device for passing liquids from the liquid container to the discharge device.
  • a pressure measuring device is provided for measuring the pressure of a liquid inside the tube device, the pressure measuring device having a cavity connected to the interior of the tube device and a pressure sensor for detecting a pressure in the cavity.
  • the method comprises the steps of increasing the pressure on a liquid in the tube device to drain liquid from the discharge device and observing the pressure in the liquid by means of the pressure measuring device.
  • one or more steps of draining the liquid are performed before the actual dosing operation. These steps can be used to check the presence of air in the system using pressure measurement.
  • a drop hanging on the discharge device is blown off.
  • FIG. 1 shows a device 20 for dosing liquids.
  • the device 20 includes a cylinder 23, a pressure measuring device 25, a first tube device 24, a second tube device 241, which opens into a discharge device 28, and a cup 29.
  • the tube devices 24 and 241 are formed as tubes.
  • the device includes a switch 500 and a liquid storage 501.
  • the cup 29 can be changed manually or automatically or it can be used as a stationary vessel, which is rinsed automatically after use.
  • the discharge device 28 is designed as a tip having an opening diameter of less than 0.4 mm.
  • the discharge device has no moving parts. If the pressure in the liquid 31 does not exceed a certain value, hydrostatic forces in the liquid cause no liquid to fall from the tube devices out of the tip. At elevated pressure, however, gravitational force and the force caused by the pressure exceed the hydrostatic forces, so that liquid emerges from the tip in the form of drops or in the form of a jet. Moving parts in the outlet device would mean the introduction of other materials, so that the other materials could pollute the liquid 31.
  • the cylinder 23 includes a housing 22 and an externally operable piston rod 21, by means of which a piston surface 222 can be moved in the interior of the housing 22.
  • the interior of the housing 22 is thereby divided into two separate rooms.
  • the space bounded by the surface of the piston surface 222 which has no piston rod is referred to as a liquid container 32 and is connected to the interior of the hose 24.
  • the tube 24 is also referred to as a first tube device and the tube 241 as a second tube device. In an alternative embodiment, the tubes 24 and 241 are replaced by tubes.
  • the liquid container 32 is also connected to a changeover switch 500. This is switchable such that either the liquid container 32 is connected to the liquid storage 501 or that the connection between the liquid container 32 and the liquid storage 501 is disconnected.
  • the interior 35 of the tube 24 and the tube 241 and the liquid container 32 of the cylinder 23 are filled with a liquid 31, e.g. with a highly reactive liquid such as hydrofluoric HF.
  • the tube 24 leads to the pressure measuring device 25, specifically into a cavity 27, against which a diaphragm, not shown in this figure, of a pressure sensor 26 rests.
  • the tube 24 is completely filled with the liquid 31, from cavity 27, a second tube 241 leads to the tip 28, which is open at the bottom. Below the tip 28 is the cup 29, in which the liquid 31 is metered filled.
  • a first cup 29 is first led under the tip 28, preferably automatically.
  • the device must be filled with liquid 31 by filling the liquid container 32 and the tubes 24 and 241 with liquid.
  • the switch 500 is actuated so that the liquid container 32 is connected to the liquid storage 501 such that liquid 31 can flow between the two vessels.
  • the liquid storage 501 was previously filled with liquid, e.g. Hydrofluoric acid, filled.
  • the piston rod 21 is moved downwards, which is repeated several times in succession. By this movement, some liquid is discharged into the cup 29, with air or other gas, which is located in the liquid 21, from the hoses 24 and 241 and the cavity 27 is pushed out.
  • the pressure is not increased so much that the liquid atomises. In the case of atomization, there is the possibility that partially drained liquid will not end up in the cup 29.
  • the device is ready for the actual dosing process, in which liquid is discharged into the now located under the top 28 cup 29.
  • the dosage is used, for example, for mixing solutions that are used in the chemical industry for high-precision etching and / or examining floating surfaces.
  • the device is particularly suitable for mixing ultra-trace solutions where the amount of contaminants is close to the detection limit.
  • Air in liquid is basically compressible. Pressure changes in the liquid can therefore not be detected as accurately as changes in pressure of pure liquid in the presence of air. The more air bubbles are in the liquid, the more compressible volume is in the liquid and changes the course of pressure changes.
  • the piston rod 21 is pressed down, for example by means of a stepping motor or a magnetic actuator.
  • the pressure in the liquid 31 increases, so that a portion of the liquid 31 exits through the tip 28 down, after which this part falls into the cup 29.
  • the tip 28 is so fine that it has a diameter of 0.3 mm in a round cross section.
  • the pressure within the liquid 31, for example by 0.2 bar increases due to the resistance formed by the tip and the hose line.
  • This change in pressure is detected by the pressure sensor 26 and output, for example, to a display unit, not shown in this figure, on which the course of the pressure over time is displayed.
  • the signal curve of the measured pressure is analyzed electronically in an evaluation device with the aid of a fast Fourier transformation. For example, it can be clearly seen on the signal course if there is a blockage in the tube 241 in the flow direction behind the pressure measuring device 25. In this case, the pressure of the liquid increases very strongly, which can be detected by means of the pressure sensor 26.
  • the dual paths to the cavity 27 through the tubes 24 and 241 serve to flush the cavity 27. Possibly occurring gas bubbles or impurities, resulting for example by detached particles of the hose can not collect in the cavity 27, since they are flushed out of this cavity 27 out.
  • the detached particles may be contaminated by surface contaminants in the production of the Material or from deposition. If the cavity were not rinsed, the contaminants would accumulate in the dead volume and could eventually be flushed out suddenly.
  • a flow direction of the liquid should be provided by the two paths. Characterized in that all liquid 31 flows from the liquid container 32, which is to flow to the discharge device 28, through the cavity 27 with a predetermined direction, it is ensured that a flushing takes place.
  • a pressure sensor which is only connected by a path to a conduit between the liquid container 32 and the discharge device 28, contains a dead volume in which contaminants and in particular air bubbles can be deposited. This would also be the case if there were two paths but they did not define a direction of flow.
  • voids are also avoided in the tube devices 24 and 241, for example, by rounding corners.
  • the impurities are discharged through the tip 28 from the tubing, preferably, of course, into a cup 29 which serves not to mix but to clean the tubing.
  • FIG. 2 shows a switch 1, the part of the pressure measuring device 25 from FIG. 1 is.
  • the turnout 1 is in FIG. 2 a plan view, shown in a sectional view and in an oblique view.
  • the switch 1 includes a first nipple 6, a second nipple 7 and third nipple 8.
  • the switch 1 also includes a switch housing 2.
  • the nipples 6, 7 and 8 are respectively screwed into the housing by means of a respective thread 18.
  • Inside the switch housing 2 is a cavity 15, which opens into the connections of the nipple 6, 7 and 8, respectively.
  • the nipples 6, 7 and 8 each have cylindrical inner cavities, so that the cavity of the nipple 8 is connected via the cavity 15 of the switch housing 2 both with the cavity of the nipple 6 and with the cavity of the nipple 7.
  • Hoses can be connected to the nipples 6, 7 and 8 from the outside or hoses can be inserted into the cavities of the nipples 6, 7 and 8.
  • FIG. 3 shows the pressure measuring device 25 with the switch 1 and the pressure sensor 26. Between the pressure sensor 26 and the switch 1, a hose 9 is provided which connects these two components, the switch 1 and the pressure sensor 26 with each other.
  • the pressure measuring device 5 includes a housing 4, inside which the cavity 27 is located.
  • the housing 4 has a hollow cylindrical extension 41.
  • the cavity 27 is thus connected via the interior 441 of the extension 41 to the interior 442 of the tube 9.
  • a membrane 19 is connected, which is provided between the cavity 27 and a pressure chamber 13 and which bends depending on the pressure in the cavity 27.
  • This is measured in the pressure chamber 31 by means of a piezoelectric sensor not shown in this figure. At this piezoelectric sensor are connected by electrical lines 14, which lead to an evaluation unit 33.
  • the electrical voltage between the two terminals of the lines 14 increases or decreases.
  • This electrical voltage is converted in the evaluation unit 33 into a value for the pressure.
  • the calculated pressure is plotted on a display unit 34 over time.
  • the course of the pressure is stored in a memory 38.
  • the measured pressure is applied to a control device 35 for controlling the movement of the in FIG. 1 shown piston rod 21 issued.
  • the tube 241 is connected. In the cavity of the nipple 6 of the tube 24, for the sake of clarity in FIG. 3 partially represented as a single stroke.
  • the tube 24 extends through the cavity of the switch housing 2, the interior of the nipple 8, the interior of the tube 9 to the cavity 27 of the pressure sensor 26th
  • the liquid thus flows from the tube 24 into the cavity 27 and from there into the tube 241. This results in a movement of the liquid in the cavity 27, which causes liquid to pass through the interior 442 of the tube 9, through the cavity 15 of the Switch body 2, flows through the nipple 7 to the tube 241, after which it to the top 28th flows and is drained there.
  • an O-ring is also provided, which presses below the nipple 8 from the outside against the hose 9, so that it is sealed.
  • FIG. 4 shows a further embodiment of a pressure measuring device 25.
  • This has a cavity 27, to which the inside of the tube 24 is connected from a first side and the inside of the tube 241 on the other, the first side opposite side.
  • the cavity 27 is flowed through by the liquid from bottom to top.
  • the cavity 27 is shaped so that it has no corners, since deposits can form in corners for impurities.
  • a pressure sensor 26 is provided laterally between the inlets for the tubes 24 and 241.
  • FIG. 5 shows an example of the pressure curve during a dosing process.
  • a metering device with two liquid containers, two tube devices, two pressure measuring devices and eight cups 29 is used.
  • Each of the liquid containers is connectable via a multiplexer to each of the eight cups, which means that an 8 to 1 multiplexer is provided downstream of the pressure measuring device so that one of the eight cups can be filled from each liquid container.
  • the curve marked with the triangle denotes a dosing process from the first liquid container and the curve marked with a square indicates a second dosing process from the second liquid container.
  • the pressure in millibars is plotted over the time in seconds.
  • the two curves show the two different metering operations, which are independent of each other but occur simultaneously.
  • the baseline of the two curves is slightly different, this is because the absolute values of the sensor were calibrated differently, which was left in favor of a better representation.
  • the curve marked with a triangle shows a dosing process that is inconspicuous, from which it is concluded that there was no error.
  • the pressure inside hoses 24 and 241 increases by about 100 mbar. This should actually be done in the device whose pressure curve is marked with a rectangle. However, it is noticeable that the pressure in the first discharge increases by more than 200 millibars. From this it can be concluded that there was a blockage in the discharge device leading to a higher resistance for the liquid and thus to an increased pressure leads. In subsequent draining operations this blocking is no longer visible.
  • FIG. 6 shows the course of another dosing process as in FIG. 5 after the hose that had been clogged was replaced. It is noticeable that the pressure on the curve marked with the rectangle only increases slowly. This is because air was previously in the hose and the level of fluid in the hoses is only rising slowly. This means that the capillaries have filled only during this dosing. The same would result if the metering device is moved up during the dumping process.
  • FIG. 7 shows the course of the pressure inside the liquid of the tube device during a venting process.
  • the curve drawn with the rectangle shows how the pressure increases in two phases and then decreases again.
  • there are two more of these phases whereby before each of these phases a short pressure pulse can be seen in each case upwards.
  • the piston rod is guided down in the cylinder and thus increases the pressure in the liquid.
  • the pressure increases only slowly, ie over a period of about 40 seconds. This is because there are air bubbles in the fluid that are compressible.
  • a device which, in addition to the device disclosed in U.S. Pat FIG. 1 is shown, a filling vessel and a valve.
  • a valve is adjustable so that the liquid container is connected either to the contents of the filling vessel or to the interior of the tube 24.
  • the liquid container For filling the liquid container, it is connected to the interior of the filling vessel, wherein the piston rod is lifted.
  • the liquid container is connected to the interior of the tube 24 and the piston rod is lowered.
  • the valve on the piston is switched so that the liquid container is no longer connected to the liquid in the tube device, but with the liquid inside the filling vessel. Subsequently, the piston is lifted, so that again liquid flows from the filling vessel into the liquid container of the cylinder.
  • the valve is switched so that the liquid container of the cylinder is reconnected to the interior of the tube device. Subsequently, the piston is lowered again, so that the pressure in the liquid is increased.
  • FIG. 8 shows a further course of pressure signals in a group of Dosiervorticiann. It turns out that the pressure changes that are supposed to take place every 10,000 seconds do not occur any longer from the time of 6,000 seconds on the curve marked with the triangle. This was due to the fact that a clutch to control the piston of the cylinder was broken and thus no liquid was drained. Such serious errors can be detected with the help of the printing device.
  • FIG. 9 shows the pressure curve during a complete dosing process with rinsing and venting.
  • several liquids are simultaneously discharged into a cup, each with different cylinders and with different tube devices.
  • time 520 seconds one peak can be seen downwards.
  • the piston is driven slightly upwards at this time in order to avoid that drops that can form after a drop of a drop due to minimal fluctuations in the further course of time and still fall.
  • liquid is drawn back into the tube by means of negative pressure at the discharge device. This prevents changes in the concentration of the mixture in the cup due to unintentional discharge in stationary vessels for extended periods of time.

Landscapes

  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Loading And Unloading Of Fuel Tanks Or Ships (AREA)

Claims (15)

  1. Dispositif (20) de dosage d'un liquide (31) comprenant
    - un récipient de liquide (32) ;
    - un dispositif d'évacuation (28) ;
    - un dispositif de mesure de la pression (25) comprenant une cavité (27) et un capteur de pression (26) pour mesurer la pression dans la cavité (27) ;
    - un premier dispositif de tubes (24) pour guider le liquide (31) du récipient de liquide (32) à la cavité (27) en passant par l'intérieur (35) du premier dispositif de tubes (24) ; et
    - un second dispositif de tubes (241) pour guider le liquide (31) de la cavité (27) au dispositif d'évacuation (28) en passant par l'intérieur (35) du second dispositif de tubes (241) ;
    - le dispositif étant conçu pour évacuer du liquide (31) hors du récipient de liquide (32) par le dispositif d'évacuation (28) ;
    caractérisé par
    - un réservoir de liquide (501) ; et
    - un commutateur (500), qui peut être commuté de telle manière que soit le récipient de liquide (32) est relié au réservoir de liquide (501), soit la liaison entre le récipient de liquide (32) et le réservoir de liquide (501) est coupée ;
    - le dispositif étant conçu de telle manière que, par l'actionnement du commutateur (500), le récipient de liquide (32) est relié au réservoir de liquide (501) de telle sorte que le récipient de liquide (32) et les dispositifs de tubes (24, 241) sont remplis de liquide (31) ; et
    - le dispositif étant conçu de telle manière que tout le liquide (31) qui s'écoule du récipient de liquide (32) au dispositif d'évacuation (28) passe par la cavité (27) dans un sens prédéfini.
  2. Dispositif selon la revendication 1, dans lequel le récipient de liquide (32) est entièrement rempli de liquide (31).
  3. Dispositif selon la revendication 1 ou 2, dans lequel le premier dispositif de tubes (24) contient un tuyau, qui débouche dans la cavité (27).
  4. Dispositif selon l'une des revendications 1 à 3, dans lequel le dispositif d'évacuation (28) ne comporte pas de pièces mobiles.
  5. Dispositif selon l'une des revendications 1 à 4, dans lequel le dispositif d'évacuation (28) comporte une pointe ouverte vers le bas ayant une section de passage inférieure à 0,4 mm.
  6. Dispositif selon l'une des revendications 1 à 6, dans lequel le capteur de pression (26) contient un élément piézoélectrique.
  7. Dispositif selon l'une des revendications 1 à 6, dans lequel les signaux détectés par le capteur de pression (26) sont interprétés de manière électronique dans une unité d'évaluation (33) et des messages d'erreurs sont émis en fonction des variations des signaux.
  8. Dispositif selon l'une des revendications 1 à 7, dans lequel un dispositif d'augmentation de pression (21) est prévu pour augmenter la pression du liquide (31) dans le récipient de liquide (32).
  9. Dispositif selon la revendication 8, dans lequel un dispositif de régulation est prévu pour réguler le dispositif d'augmentation de pression (21), la valeur détectée par le capteur de pression (26) étant transmise au dispositif de régulation comme signal de rétroaction.
  10. Procédé de dosage d'un liquide (31), au moyen d'un dispositif selon l'une des revendications 1 à 9, le procédé comprenant les étapes consistant à :
    - relier le récipient de liquide (32) au réservoir de liquide (501),
    - remplir le récipient de liquide (32) avec du liquide (31) provenant du réservoir de liquide (501),
    - couper la liaison entre le récipient de liquide (32) et le réservoir de liquide (501), et
    - augmenter la pression dans le récipient de liquide (32) pour évacuer du liquide (31) hors du dispositif d'évacuation (28).
  11. Procédé selon la revendication 10, dans lequel, pendant l'étape d'augmentation de la pression dans le dispositif, aucune pièce n'est déplacée dans le chemin entre le récipient de liquide (32) et le dispositif d'évacuation (28).
  12. Procédé selon la revendication 10 ou 11, dans lequel l'étape d'augmentation de la pression est exécutée au moins deux fois, le premier dispositif de tubes (24) et le second dispositif de tubes (242) étant balayés lors d'une première exécution et une quantité prédéfinie de liquide (31) étant évacuée de manière dosée lors d'une seconde exécution.
  13. Procédé selon l'une des revendications 10 à 12, dans lequel, lors de l'évacuation de liquide (31) hors du dispositif d'évacuation (28), du liquide tombe sous forme de gouttes ou de jet.
  14. Procédé de dosage d'un liquide (31) dans un récipient au moyen d'un dispositif selon l'une des revendications 1 à 9,
    - le procédé comprenant une étape consistant à exercer une pression sur le liquide (31) pour évacuer le liquide (31),
    - la pression étant mesurée par le capteur de pression (26) et la pression mesurée étant indiquée sur un dispositif d'indication (34), et
    - avant l'étape consistant à exercer une pression sur le liquide (31), une pression et dépression étant exercées alternativement sur le liquide (31) pour évacuer l'air du liquide (31).
  15. Procédé selon la revendication 14, dans lequel, avant le procédé de dosage, une ou plusieurs étapes d'évacuation du liquide (31) dans un récipient cible étant prévues pour évacuer l'air et dans lequel une goutte suspendue au dispositif d'évacuation (28) est éliminée sélectivement par soufflage avant le procédé de dosage.
EP13704546.4A 2012-01-26 2013-01-28 Dispositif et methode de dosage d'un liquide Active EP2806973B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102012001438A DE102012001438A1 (de) 2012-01-26 2012-01-26 Vorrichtung und Verfahren zum Dosieren von Flüssigkeiten
PCT/EP2013/000247 WO2013110474A1 (fr) 2012-01-26 2013-01-28 Dispositif et procédé de dosage de liquides

Publications (2)

Publication Number Publication Date
EP2806973A1 EP2806973A1 (fr) 2014-12-03
EP2806973B1 true EP2806973B1 (fr) 2019-09-18

Family

ID=47720466

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13704546.4A Active EP2806973B1 (fr) 2012-01-26 2013-01-28 Dispositif et methode de dosage d'un liquide

Country Status (3)

Country Link
EP (1) EP2806973B1 (fr)
DE (1) DE102012001438A1 (fr)
WO (1) WO2013110474A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102016014457A1 (de) * 2016-12-05 2018-06-07 Pva Tepla Ag Probengefäß zur Aufnahme kleinvolumiger flüssiger Proben
DE102018206078A1 (de) * 2018-04-20 2019-10-24 Festo Ag & Co. Kg Dosiersystem und Verfahren zur Dosierung einer vorgebbaren Flüssigkeitsmenge

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3531241A1 (de) 1985-08-31 1987-03-05 Eppendorf Geraetebau Netheler Vorrichtung zur gesteuerten ausgabe von fluessigkeiten
DE3803594A1 (de) * 1988-02-06 1989-08-17 Ver Foerderung Inst Kunststoff Verfahren und vorrichtung zur messung des gasbeladungszustandes eines fluids bei der verarbeitung von gefuellten und ungefuellten fluiden
DE4105148A1 (de) * 1991-02-20 1992-08-27 Draegerwerk Ag Narkosemitteldosiervorrichtung
EP0865824B1 (fr) * 1997-03-20 2004-05-19 F. Hoffmann-La Roche Ag Dispositif de pipetage micromécanique
WO1999042804A2 (fr) * 1998-02-20 1999-08-26 Cartesian Technologies, Inc. Procede d'aspiration et de distribution microfluidique
IL148611A0 (en) * 1999-09-14 2002-09-12 Pharmacopeia Inc Flow control elements for use in liquid dispensers
DE10118875C1 (de) * 2001-04-18 2002-09-12 Eppendorf Ag Verfahren zum kontrollierten Dosieren von Flüssigkeiten unter Verdrängung eines Gaspolsters
DE10232721A1 (de) * 2002-07-16 2004-02-12 Siemens Ag Druckgeber mit Drucksensor in mikromechanischer Bauweise
US7927270B2 (en) * 2005-02-24 2011-04-19 Ethicon Endo-Surgery, Inc. External mechanical pressure sensor for gastric band pressure measurements
DE202006010293U1 (de) * 2005-07-22 2006-08-31 Tecan Trading Ag Pipettiergerät mit Computerprogrammprodukt zum Akzeptieren oder Verwerfen von pipettierten Flüssigkeitsproben
DE102005055697B4 (de) * 2005-11-23 2011-12-29 Allmendinger Elektromechanik Gmbh Vorrichtung zur dosierten Abgabe eines Fluids und Gerät mit einer solchen Vorrichtung
JP5223555B2 (ja) * 2008-02-19 2013-06-26 株式会社デンソー 燃料噴射装置及び蓄圧式燃料噴射装置システム

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
None *

Also Published As

Publication number Publication date
DE102012001438A1 (de) 2013-08-01
WO2013110474A9 (fr) 2013-12-12
WO2013110474A1 (fr) 2013-08-01
EP2806973A1 (fr) 2014-12-03

Similar Documents

Publication Publication Date Title
DE102012209314B4 (de) Vorrichtung und Verfahren zur Abgabe oder Aufnahme eines Flüssigkeitsvolumens
CH699313A1 (de) Probenaufgabevorrichtung.
WO2016030013A1 (fr) Procédé et dispositif pour réaliser un test d'intégrité d'un élément filtrant
DE2640491A1 (de) Automatischer pipettierapparat
EP2633914B1 (fr) Dispositif de pipetage et son procédé de fabrication
EP3462140B1 (fr) Procédé et dispositif de dosage pour une distribution de fluide dosée
WO2016146718A1 (fr) Dispositif de nettoyage et procédé de fonctionnement
EP2806973B1 (fr) Dispositif et methode de dosage d'un liquide
EP3290064B1 (fr) Systeme de mesure d'une quantite d'un liquide dans un sac plastique
EP0661529B1 (fr) Procédé et dispositif d'essai d'étanchéité d'un volume et pour déterminer la quantité de fuite
CH712572B1 (de) Handpipettiergerät.
DE69400052T2 (de) Mikrodosierverfahren für Flüssigkeiten zur Erzielung nanovolumetrischer Lösungen
DE102011081186A1 (de) Verfahren zum Detektieren der Oberfläche einer Flüssigkeitsprobe in einem Probenbehälter
DE102007010412B4 (de) Vorrichtung und Verfahren zum Dosieren von Flüssigkeiten in gasgefüllte Räume
DE102021109076A1 (de) Dosiervorrichtung und Verfahren zum Dosieren von flüssigen Medien
EP2006020B1 (fr) Agencement de traitement d'échantillons pour un dispositif de dosage de liquides
DE102011003615A1 (de) Verfahren und Vorrichtung zur Messung eines Volumenstroms einer in einen Behälter einströmenden Flüssigkeit und/oder eines in den Behälter eingeströmten Volumens der Flüssigkeit
EP3164681B1 (fr) Système de dosage hydrostatique et procédé de dosage de fluides utilisant un tel système de dosage
EP3370040B1 (fr) Procédé de détermination du volume de gaz dans une seringue préremplie et usage du procédé pour calibrer une machine de remplissage de seringues
DE102009001612A1 (de) Erzeugung konstanter pulsationsfreier Flüssigkeitsströme für Mikrofluidikanwendungen
DE102009037105A1 (de) Dispenser
DE102016219783B4 (de) Prüfstand zur Simulation der herrschenden Beanspruchung in Klebstoffanlagen
DE102008016549A1 (de) Dosiervorrichtung für kontaktfreie Flüssigkeitsabgabe
EP3519781B1 (fr) Tête de distribution pour pompe d'aspiration
EP3104138A1 (fr) Compteur à gaz

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20140709

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: PVA TEPLA AG

DAX Request for extension of the european patent (deleted)
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20180926

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

INTG Intention to grant announced

Effective date: 20190416

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE PATENT HAS BEEN GRANTED

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: PVA TEPLA AG

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

Free format text: NOT ENGLISH

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 502013013603

Country of ref document: DE

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 1180671

Country of ref document: AT

Kind code of ref document: T

Effective date: 20191015

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

Free format text: LANGUAGE OF EP DOCUMENT: GERMAN

REG Reference to a national code

Ref country code: NL

Ref legal event code: FP

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190918

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191218

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191218

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190918

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190918

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190918

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: RS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190918

Ref country code: AL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190918

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190918

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191219

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20200120

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190918

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190918

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190918

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190918

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190918

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20200224

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190918

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190918

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 502013013603

Country of ref document: DE

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

PG2D Information on lapse in contracting state deleted

Ref country code: IS

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190918

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20200119

26N No opposition filed

Effective date: 20200619

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190918

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190918

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200128

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200131

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200131

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200128

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190918

Ref country code: MT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190918

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190918

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190918

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 20240126

Year of fee payment: 12

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: AT

Payment date: 20240124

Year of fee payment: 12

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20240131

Year of fee payment: 12

Ref country code: GB

Payment date: 20240124

Year of fee payment: 12

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IT

Payment date: 20240129

Year of fee payment: 12

Ref country code: FR

Payment date: 20240126

Year of fee payment: 12

Ref country code: BE

Payment date: 20240124

Year of fee payment: 12