EP3471882B1 - Embout de systeme de pipetage presentant une conicite double - Google Patents

Embout de systeme de pipetage presentant une conicite double Download PDF

Info

Publication number
EP3471882B1
EP3471882B1 EP17734800.0A EP17734800A EP3471882B1 EP 3471882 B1 EP3471882 B1 EP 3471882B1 EP 17734800 A EP17734800 A EP 17734800A EP 3471882 B1 EP3471882 B1 EP 3471882B1
Authority
EP
European Patent Office
Prior art keywords
outer diameter
retaining elements
maximum outer
tip
defining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP17734800.0A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP3471882A1 (fr
Inventor
Bruno DUDEK
Jonathan BARBIEUX
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gilson SAS
Original Assignee
Gilson SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilson SAS filed Critical Gilson SAS
Priority to PL17734800T priority Critical patent/PL3471882T3/pl
Publication of EP3471882A1 publication Critical patent/EP3471882A1/fr
Application granted granted Critical
Publication of EP3471882B1 publication Critical patent/EP3471882B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0275—Interchangeable or disposable dispensing tips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0286—Ergonomic aspects, e.g. form or arrangement of controls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/023—Adapting objects or devices to another adapted for different sizes of tubes, tips or container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/08—Ergonomic or safety aspects of handling devices
    • B01L2200/087—Ergonomic aspects
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0275—Interchangeable or disposable dispensing tips
    • B01L3/0279—Interchangeable or disposable dispensing tips co-operating with positive ejection means

Definitions

  • the present invention relates to the field of multichannel pipetting systems such as automated pipetting systems called robots, and single-channel or multichannel sampling pipettes, also known as laboratory pipettes, or air displacement liquid transfer pipettes. for calibrated sampling and introduction of liquid into containers.
  • multichannel pipetting systems such as automated pipetting systems called robots
  • single-channel or multichannel sampling pipettes also known as laboratory pipettes, or air displacement liquid transfer pipettes.
  • laboratory pipettes also known as laboratory pipettes, or air displacement liquid transfer pipettes.
  • the invention relates more particularly to the design of the tips of these pipetting systems, the tips being intended to carry the sampling cones forming consumable elements.
  • each nozzle comprises two annular cone holding portions each projecting on the outer surface of the nozzle, and spaced apart from each other in an axial direction of the nozzle.
  • the upper support portion in the form of a bead, essentially fulfills the friction holding function of the cone and limits the introduction into the latter in the endpiece.
  • the lower portion although also involved in maintaining the cone, fulfills the sealing function between the sampling cone and the nozzle. Together, the two holding portions ensure the centering of the tip and the cone.
  • this design has the particularity of dissociating the means of the nozzle dedicated to the mechanical maintenance of the cone by friction, and those dedicated to obtaining the seal, formed by a lip seal, whose bending force of the lip is substantially less than the compression force of a conventional O-ring.
  • the solution of the document FR 3,026,658 provides a response to the need for reduction of the fitting force / ejection force, while ensuring the sealing and mechanical strength of the cones, even when they are solicited.
  • Such mechanical stressing occurs for example during a "licking" movement performed by the operator, during which the ends of the cones scrape the inner surface of a well in order to transfer the last drop of liquid likely to be retained by capillarity at the end of the consumable.
  • the annular holding portions may be made using spaced apart point elements, such as this is also mentioned in the document FR 3,026,658 . It is therefore a technique that enhances the mechanical strength of the cone, without increasing the fitting force.
  • the solution of the document FR 3,026,658 is based on the presence of a seal arranged between two holding / mechanical retaining zones of the sampling cone, which can be applied to a single-channel pipette, even if it is of particular interest for multichannel pipettes.
  • the invention firstly relates to a taper cone holder for the lower part of the pipetting system, the tip having a longitudinal axis forming a first fictitious plane.
  • the tip also carries a seal arranged between the first and the third annular zone of the tip.
  • firstly the first maximum outer diameter and the second maximum outer diameter are different so as to jointly define a first tip portion having a first taper
  • secondly the second maximum outer diameter as well as the third maximum outside diameter are different so as to jointly define a second tip portion having a second taper less than the first taper.
  • the invention is remarkable in that it makes it possible to define two portions of nozzle which succeed one another axially and which therefore have different conicities, which can adapt to a wide variety of sampling cones.
  • the cone will be retained by friction by the first and second groups of retaining elements, or by the second and third groups of retaining elements, while cooperating with the seal to seal .
  • the double mechanical retention of the cone, by friction ensures a satisfactory maintenance of the latter, in particular during a movement of "licking" on well made by the operator.
  • the range of use of such endpieces is widely extended, without compromising on the maintenance, alignment and sealing of the sampling cones, nor on the intensity of the fitting force to be produced. when coupling between the tip and the cone.
  • the invention also relates to a lower portion of a pipetting system comprising at least one such taper cone holder.
  • This lower part may be intended for a single-channel pipetting system, and then comprise a single sampling cone tip.
  • the lower part of the pipette is intended for a multichannel pipetting system, and comprises a plurality of sampling tip-cone tips having longitudinal axes forming part of said first fictitious plane.
  • the invention has at least one of the following optional features, taken alone or in combination.
  • the first retaining elements of the first group are located radially inwardly and at a distance from a first imaginary circle defined by said first maximum outer diameter.
  • This non-axisymmetrical design makes it possible to deform the flange of a cone in a non-circular manner by means of the first two retaining elements defining the first maximum outside diameter. It advantageously results an even greater extension of the range of use of the tip.
  • first retaining elements in addition to said two first retaining elements defining the first maximum outer diameter, one or more pairs of first retaining elements defining one or more diameters smaller than the first outer diameter. maximum, including at least a first lower diameter located in said first fictitious plane. This allows a substantially elliptical deformation of the flange of a cone, for an increase in the range of use of the tip which is then able to adapt to various conic flanges.
  • the third retaining elements of the third group are located radially inwards and away from a third imaginary circle defined by said third maximum outside diameter.
  • the third group comprises, in addition to said two third retaining elements defining the third maximum outer diameter, one or more pairs of third retaining elements defining one or third diameters smaller than the third maximum outer diameter, among which at least a third lower diameter located in said first fictitious plane.
  • the second retaining elements of the second group are located on a second imaginary circle defined by said second maximum outside diameter.
  • a non-axisymmetric solution such as that described above for the first and third groups could be adopted for the second group, without departing from the scope of the invention.
  • the second group comprises, in addition to said two second retaining elements defining the second maximum outside diameter, one or more pairs of second retaining elements defining one or more other second diameters. outermost ones, including at least one second maximum outside diameter located in said first fictitious plane.
  • the first conicity is between 3 and 4.5 °, and in that the second conicity is between 2 and 3.4 °.
  • the number of tips is between 2 and 16, and even more preferably between 8 and 12.
  • the seal is preferably a lip seal.
  • it could be an O-ring, without departing from the scope of the invention.
  • the subject of the invention is also a pipetting system comprising a lower part as described above, said pipetting system being a manual, motorized, or hybrid sampling pipette, or this system being an automated pipetting system, said robot.
  • the invention relates to an assembly comprising such a pipetting system, and at least one sampling cone mounted on the tip and retained thereon by friction with the first and second retaining elements, or with the second and third retainers.
  • FIG. 1 With reference first to the figure 1 , there is shown a multichannel sampling pipette 1, according to a preferred embodiment of the present invention. Nevertheless, the invention is not limited to multichannel pipettes, but applies analogously to so-called “single channel” pipettes, such as the pipette shown in FIG. figure 8 .
  • the pipette 1 with air displacement, manual or motorized comprises in the upper part a handle body 2, as well as a lower part 4 also object of the present invention, incorporating at its lower end cone holder tips pipette 6, on which cones or consumables 8 are to be fitted.
  • Each cone 8 and its associated end 6 form an assembly also suitable for the present invention.
  • the sample cone-holder tips 6 are spaced from one another in a lateral direction of the pipetting system, or the pipette lateral direction, represented by the arrow 10.
  • Each nozzle 6 has a longitudinal axis 7, also called a central axis, orthogonal to the direction 10. All the longitudinal axes 7 are parallel and written in a first fictional plane P1 parallel to the direction 10.
  • a second fictional plane P2 has been represented on the figure 1 this second plane P2 being orthogonal to the first plane P1 and parallel to a central pipette longitudinal axis 14.
  • each tip 6 is associated with a first fictional plane P1 and a second fictional plane P2 interspersed at the longitudinal axis 7 of the tip concerned.
  • the plane P2 there is also a direction 15 of movement of the pipette by the operator during a movement called "licking", during which the pipette is moved step by step over successive lines of wells.
  • a plate to dispense the liquid previously taken from the pipette.
  • the number of tips 6 is preferably between 8 and 12, and that the plate used has as many rows of wells, and a number of lines adapted for example to reach 384 wells.
  • Each nozzle 6 has a through orifice 12 communicating at its upper end with a suction chamber (not visible on the figure 1 ), and at its lower end with a sampling cone 8.
  • the through orifice 12 is centered on its associated tip 6, that is to say that it is centered on the longitudinal axis 7 of the tip on which is centered the grip cone 8.
  • the lower part 4 is preferably mounted in a screwed manner on the body 2 forming a handle.
  • the lower part 4 comprises a fixed body 16 covered by an outer removable cover 17, and at its lower end, the end pieces 6.
  • the movable inner parts of this lower part 4 are conventional, and will not be further described . They concern in particular a plurality of pistons parallel to the axis 14 and each associated with a tip 6.
  • the tip 6, at its lower end, has an outer surface 20 of cylindrical or frustoconical overall shape, narrowing downwardly.
  • the tip is equipped with four zones of cooperation with the cones that it is likely to receive, these zones being spaced apart from one another along the longitudinal axis 7.
  • first group there are three groups of friction retaining elements of the sampling cones.
  • the lowest group is the first group, having first retainers arranged projecting radially outwardly from a first area 20-1 of the surface 20, and circumferentially spaced from each other.
  • first retaining elements among which two first retaining elements 24-1a arranged in the second dummy plane P2, and defining an outer diameter of larger dimension, said first maximum outside diameter Dmax1.
  • This diameter Dmax1 defines a first imaginary circle C1 centered on the axis 7 and inside which are circumscribed two other first retaining elements 24-1b, at a distance radially from this same circle.
  • the two elements 24-1b together form a pair which defines a first lower diameter Dinf1 of smaller dimension than that of the diameter Dmax1.
  • This diameter Dinf1 is orthogonal to the diameter Dmax1, and located in the fictitious first plane P1.
  • a second group comprising second retaining members arranged projecting radially outwardly from a second zone 20-2 of the surface 20, and spaced circumferentially from each other. It is here four second retaining elements, among which two second retaining elements 24-2a arranged in the second dummy plane P2, and defining an outer diameter of larger dimension, said second maximum outside diameter Dmax2.
  • This diameter Dmax2 defines a second imaginary circle C2 centered on the axis 7 and on which there are also two other second retaining elements 24-2a.
  • These two other elements together form a pair which defines another second maximum outside diameter Dmax2, located in the notional first plane P1.
  • the two maximum outer diameters Dmax2 are of the same size, and, more generally, all the second retaining elements 24-2a are inscribed on the same second imaginary circle C2.
  • the highest group on the tip is the third group, having third retainers arranged projecting radially outwardly from a third zone 20-3 of the surface 20, and spaced circumferentially from each other .
  • This diameter Dmax3 defines a third imaginary circle C3 centered on the axis 7 and inside which are circumscribed two other third retaining elements 24-3b, at a distance radially from this same circle.
  • the two elements 24-3b together form a pair which defines a third lower diameter Dinf3 of smaller dimension than that of the diameter Dmax3.
  • This diameter Dinf3 is orthogonal to the diameter Dmax3, and located in the imaginary first plane P1.
  • the fourth zone of cooperation with the cone is constituted by an annular seal 26, housed in a groove 28 of the outer surface 20 of the tip. It is preferably a lip seal 26 to reduce the fitting force, this seal being located between the first group and the second group. Alternatively, the seal 26 could be arranged between the second group and the third group, without departing from the scope of the invention.
  • the lip seal 26 has one or more lips, preferably one.
  • the lip is frustoconical in shape, flaring upwardly from an annular base of the joint.
  • the annular base and the lip are preferably made in one piece, made of EPDM elastomer material, having a Shore A hardness of 40 to 100.
  • the lip seal 26 has an outer diameter, for example of the order of 4 mm.
  • the first outer maximum diameter Dmax1 is smaller than the second outer maximum diameter Dmax2. Together they define, thanks to their difference in size, a first longitudinal portion of tip 6a centered on the axis 7 and having a first conicity schematized by the line referenced Con1 on the figure 2 .
  • the second maximum outside diameter Dmax2 is smaller than the third maximum outside diameter Dmax3. Together they define, thanks to their difference in size, a second longitudinal portion of tip 6b adjacent to the first portion 6a, and also centered on the axis 7.
  • the second portion 6b has a second conicity schematized by the line referenced Con2 on the figure 2 this second conicity being lower than the first.
  • the first conicity Con1 is between 3 and 4.5 °, while the second conicity Con2 is between 2 and 3.4 °.
  • the flange 8a of the cone to be fitted will see its inner surface held by friction either by the first and the second group of retaining elements, or by the second and third groups of elements. detention. In all cases, the frictional retention will be well achieved using two groups spaced axially from each other, for a satisfactory mechanical maintenance and for the conservation of the centering and parallelism between the cones present on different multichannel pipette tips.
  • the seal represents a function filled separately, by the dedicated seal 26.
  • the figure 4 thus shows the contact between firstly the first elements 24-1a and the frustoconical inner surface of the flange of the cone, and secondly between the second elements 24-2a and the same inner surface.
  • the dimension of the cone is such that its retention at the first group is exclusively achieved by the first two elements 24-1a, since there is no contact with the other two first elements 24-1b .
  • This example is shown on figures 4 and 5a .
  • the second group makes contact between each of its retaining elements 24-2a and the inner surface of the collar, as shown in FIG. figure 5b .
  • the cone 8 having a larger dimension is deformed by the support of the first elements 24-1a during a deeper penetration of the tip 6 into the cone, this deformation having a substantially elliptical character leading to contact with the other first elements 24-1b with the inner surface of the cone.
  • the figure 6 shows the contact between on the one hand the second elements 24-2a and the frustoconical inner surface of the flange of the cone, and secondly between the third elements 24-3a and the same inner surface.
  • the dimension of the cone is such that its retention at the third group is exclusively achieved by the two third elements 24-3a, since there is no contact with the other two third elements 24-3b.
  • This example is shown on figures 6 and 7c .
  • the second group here also establishes a contact between each of its retaining elements 24-2a and the inner surface of the collar, as shown in FIG. figure 7b .
  • the cone 8 having a larger dimension is deformed by the support of the third elements 24-3a during a deeper penetration of the tip 6 into the cone, this deformation having a substantially elliptical character leading to contact with the other thirds elements 24-3b with the inner surface of the cone.

Landscapes

  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
EP17734800.0A 2016-06-17 2017-06-15 Embout de systeme de pipetage presentant une conicite double Active EP3471882B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL17734800T PL3471882T3 (pl) 2016-06-17 2017-06-15 Końcówka systemu do pipetowania o podwójnej stożkowatości

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1655652A FR3052688B1 (fr) 2016-06-17 2016-06-17 Embout de systeme de pipetage presentant une conicite double
PCT/FR2017/051552 WO2017216489A1 (fr) 2016-06-17 2017-06-15 Embout de systeme de pipetage presentant une conicite double

Publications (2)

Publication Number Publication Date
EP3471882A1 EP3471882A1 (fr) 2019-04-24
EP3471882B1 true EP3471882B1 (fr) 2019-12-11

Family

ID=56855645

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17734800.0A Active EP3471882B1 (fr) 2016-06-17 2017-06-15 Embout de systeme de pipetage presentant une conicite double

Country Status (10)

Country Link
US (1) US10933411B2 (https=)
EP (1) EP3471882B1 (https=)
JP (1) JP6888032B2 (https=)
KR (1) KR20190019072A (https=)
CN (1) CN109311016B (https=)
CA (1) CA3027936A1 (https=)
ES (1) ES2776884T3 (https=)
FR (1) FR3052688B1 (https=)
PL (1) PL3471882T3 (https=)
WO (1) WO2017216489A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USD772426S1 (en) * 2014-01-13 2016-11-22 Gilson, Inc. Pipette system cartridge
DE102022004362A1 (de) * 2022-11-07 2024-05-08 Brand Gmbh + Co Kg Pipettenschaft einer Pipettiervorrichtung

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2807345B1 (fr) * 2000-04-07 2002-07-12 Gilson Sa Pipette de prelevement a demontage simplifie
JP4382252B2 (ja) * 2000-05-16 2009-12-09 アロカ株式会社 ノズル装置
US6550349B1 (en) * 2000-09-19 2003-04-22 Molecular Devices Corporation Pipette tip holder
US6596240B2 (en) * 2001-01-12 2003-07-22 Porex Corporation Pipette tip for easy mounting and ejecting from a pipette
US6967004B2 (en) * 2001-10-30 2005-11-22 Rainin Instrument, Llc Pipette with improved pipette tip and mounting shaft
FI20031683A0 (fi) * 2003-11-19 2003-11-19 Thermo Electron Oy Pipetti jossa on kärjenpoistomekanismi
EP1862219B1 (de) * 2006-05-29 2018-02-07 Qiagen GmbH Vorrichtung zur halterung von pipettenspitzen sowie pipettiervorrichtung
US7662344B2 (en) * 2006-10-24 2010-02-16 Viaflo Corporation Locking pipette tip and mounting shaft
FI121457B (fi) * 2009-03-24 2010-11-30 Thermo Fisher Scientific Oy Kärkiosapipetti
JP2011149767A (ja) * 2010-01-20 2011-08-04 Fukae Kasei Kk ピペット装置
JP5635811B2 (ja) * 2010-05-28 2014-12-03 深江化成株式会社 ピペット装置
US8858898B2 (en) * 2012-05-16 2014-10-14 Gene Era Biotech Co. Ltd. Pipette tip with improved seal
EP2914380B1 (en) * 2012-11-02 2020-02-26 Biotix, Inc. Pipetting system device
FR3019895B1 (fr) 2014-04-10 2016-05-27 Gilson Sas Systeme de pipetage multicanaux comprenant deux chambres d'aspiration imbriquees l'une dans l'autre
FR3026658B1 (fr) * 2014-10-02 2020-12-25 Gilson Sas Embout de pipette comprenant un joint a levre
FR3026648A1 (fr) * 2014-10-06 2016-04-08 Sorin Crm Sas Accessoire d'explantation de capsule intracorporelle
FR3037825B1 (fr) 2015-06-24 2017-07-28 Gilson Sas Bouton de commande ameliore pour pipette de prelevement
FR3040896B1 (fr) * 2015-09-15 2017-10-13 Gilson Sas Pipette de prelevement comprenant un organe de commande a double fonction d'ejection de cone et de deverrouillage du systeme de reglage de volume

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
None *

Also Published As

Publication number Publication date
FR3052688B1 (fr) 2018-07-06
EP3471882A1 (fr) 2019-04-24
ES2776884T3 (es) 2020-08-03
CN109311016A (zh) 2019-02-05
WO2017216489A1 (fr) 2017-12-21
PL3471882T3 (pl) 2020-05-18
CA3027936A1 (fr) 2017-12-21
US20190329239A1 (en) 2019-10-31
CN109311016B (zh) 2020-12-25
JP2019518219A (ja) 2019-06-27
FR3052688A1 (fr) 2017-12-22
JP6888032B2 (ja) 2021-06-16
KR20190019072A (ko) 2019-02-26
US10933411B2 (en) 2021-03-02

Similar Documents

Publication Publication Date Title
EP4048910B1 (fr) Dispositif de raccordement a acces exterieur a une bague d'ancrage, ensemble et procede de demontage correspondants
FR2937386A1 (fr) Moyen d'entrainement polygonal a embase incorporee.
FR2740531A1 (fr) Perfectionnement a un dispositif de liaison d'un tube a un embout
EP1412107A1 (fr) Dispositif d'outil a expansion pour pince a emboiture
EP3471882B1 (fr) Embout de systeme de pipetage presentant une conicite double
EP2443042A1 (fr) Dispositif anti-goutte pour bouteille
EP1268066B1 (fr) Pipette de prelevement a demontage simplifie
WO2017118742A1 (fr) Accessoire de préhension d'un contenant
FR3004293A1 (fr) Dispositif de fixation rapide pour connecteur en deux parties a deconnexion rapide
FR3038518A1 (fr) Seringue et son procede d'assemblage
EP2361165B1 (fr) Canon de guidage flexible pour machine-outil
EP4166836B1 (fr) Raccord rapide et ensemble de connexion comprenant un tel raccord rapide
FR3026658A1 (fr) Embout de pipette comprenant un joint a levre
EP1855804A1 (fr) Embout pour pipette de prelevement, et pipette ainsi equipee
EP2349737A1 (fr) Instrument d'ecriture comprenant un organe d'extremite monte par emmanchement
FR3126900A1 (fr) Procédé d’assemblage d’au moins une bague coopérant par frettage avec une portée de frettage d'une pièce
EP4401882B1 (fr) Dispositif de prelevement a deplacement positif, conçu pour faciliter l'ejection du capillaire
EP1549508A1 (fr) Pointe a bille pour instrument d'ecriture et son procede de fabrication
FR3108835A1 (fr) Dispositif de raclage destiné à équiper le col d’ouverture d’un récipient contenant un produit visqueux ou pâteux
WO2012168632A1 (fr) Instrument d'écriture, en particulier marqueur, à unité réservoir rechargeable
WO2016207518A1 (fr) Instrument d'écriture a pointe a usage multiple
FR3122079A3 (fr) Ensemble destiné à simuler une tige fémorale dans un fémur d’un patient
FR2916368A1 (fr) Pipette multicanaux a embouts repartis circulairement.
EP1318079A1 (fr) Ensemble de bouchage àcapuchom imperdable
EP1870183A1 (fr) Plaque réfractaire, jeu de plaques réfractaires et procédé de fabrication d'une plaque réfractaire pour utilisation dans un dispositif de changement de plaque

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: UNKNOWN

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20181220

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
INTG Intention to grant announced

Effective date: 20190920

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE PATENT HAS BEEN GRANTED

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

Free format text: NOT ENGLISH

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 1211652

Country of ref document: AT

Kind code of ref document: T

Effective date: 20191215

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602017009665

Country of ref document: DE

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

Free format text: LANGUAGE OF EP DOCUMENT: FRENCH

REG Reference to a national code

Ref country code: CH

Ref legal event code: NV

Representative=s name: BOVARD AG PATENT- UND MARKENANWAELTE, CH

REG Reference to a national code

Ref country code: FI

Ref legal event code: FGE

REG Reference to a national code

Ref country code: NL

Ref legal event code: MP

Effective date: 20191211

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20200312

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191211

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20200311

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20200311

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191211

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191211

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191211

Ref country code: RS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191211

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191211

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191211

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191211

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191211

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191211

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20200506

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2776884

Country of ref document: ES

Kind code of ref document: T3

Effective date: 20200803

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191211

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20200411

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191211

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602017009665

Country of ref document: DE

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 1211652

Country of ref document: AT

Kind code of ref document: T

Effective date: 20191211

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191211

26N No opposition filed

Effective date: 20200914

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191211

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191211

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191211

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200615

REG Reference to a national code

Ref country code: BE

Ref legal event code: MM

Effective date: 20200630

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200615

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200630

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191211

Ref country code: MT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191211

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191211

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191211

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IT

Payment date: 20220627

Year of fee payment: 6

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: ES

Payment date: 20220929

Year of fee payment: 6

P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20230511

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20240729

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230615

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230616

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230616

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FI

Payment date: 20250627

Year of fee payment: 9

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: PL

Payment date: 20250606

Year of fee payment: 9

Ref country code: DE

Payment date: 20250618

Year of fee payment: 9

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20250618

Year of fee payment: 9

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20250625

Year of fee payment: 9

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 20250701

Year of fee payment: 9