EP3391816B1 - System und verfahren zur überprüfung von echtzeit-lungenmechaniken - Google Patents
System und verfahren zur überprüfung von echtzeit-lungenmechaniken Download PDFInfo
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- EP3391816B1 EP3391816B1 EP18164800.7A EP18164800A EP3391816B1 EP 3391816 B1 EP3391816 B1 EP 3391816B1 EP 18164800 A EP18164800 A EP 18164800A EP 3391816 B1 EP3391816 B1 EP 3391816B1
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Definitions
- R RS is the amount of pressure required to force a given flow of gas though the combined series resistances of the breathing circuit, ETT resistance, and physiologic airways of a mechanically ventilated patient.
- C RS is a measurement of the distensibility of the lung, meaning the elastic recoil of the lungs and the chest wall for a given volume of gas delivered. Thus, for any given volume, elastic pressure is increased by lung stiffness (as in pulmonary fibrosis) or restricted excursion of the chest wall or diaphragm ( i.e., tense ascites, massive obesity).
- C RS and R RS are calculated using an end inspiratory pause (EIP) during a constant inspiratory flow rate.
- EIP end inspiratory pause
- C RS is estimated by dividing the delivered tidal volume by inspiratory P plt , where P plt is the steady-state pressure measured during an EIP.
- R RS is estimated by dividing the difference between peak inflation pressure (PIP) and P plt by the inspiratory flow rate.
- PIP peak inflation pressure
- Some ventilators have an inspiratory flow rate setting such that the clinician can read the delivered flow rate while others give an inspiratory time setting where the clinician needs to divide the tidal volume by the inspiratory time to determine the inspiratory flow rate.
- P plt is essential for calculating C RS and R RS .
- monitoring P plt is also essential to avoid the over-distension of the alveoli, thus avoiding baro- and/or volutrauma, especially in patients with restrictive lung diseases (ARDS network protocol (July 2008); http://www.ardsnet.org/node/77791).
- EIP EIP be performed. For patients with respiratory failure, this can be accomplished by applying an EIP immediately following a tidal volume during controlled mechanical ventilation (CMV) or intermittent mandatory ventilation (IMV).
- CMV controlled mechanical ventilation
- IMV intermittent mandatory ventilation
- Temporary disruption of inhalation by applying an EIP may also predispose to patient-ventilator dysynchrony. This may lead to increased work of breathing, and the possibility of compromising arterial blood-gas exchange.
- WO 2006/012205 A2 describes a method and an apparatus for non-invasive prediction of intrinsic positive end-expiratory pressure in spontaneously breathing patients using certain markers, such as flow/volume trajectory, CO2 flow/volume trajectory, CO2 volume ratio, flow at the onset of inspiratory effort, modeling the patient's expiratory waveform, peak to mid-exhalation flow ratio, duration of low exhaled flow, capnograph waveform shape, and negative expiratory pressure or an increased expiratory gradient.
- markers such as flow/volume trajectory, CO2 flow/volume trajectory, CO2 volume ratio, flow at the onset of inspiratory effort, modeling the patient's expiratory waveform, peak to mid-exhalation flow ratio, duration of low exhaled flow, capnograph waveform shape, and negative expiratory pressure or an increased expiratory gradient.
- the invention thus provides a method for accurate and real time estimation of inspiratory plateau pressure "P plt " without using an end inspiratory pause (EIP), comprising: (a) receiving respiratory parameters of a patient from a device (5) that interfaces with a patient pulmonary system and measures the respiratory parameters; (b) calculating, with a processor unit (20), the patient's expiratory time constant " ⁇ E " using at least one respiratory parameter from step (a); and (c) calculating with the processor unit (20) at least one estimate of P plt using at least one respiratory parameter from step (a) and the patient's ⁇ E from step (b), wherein the respiratory parameters used at step (b) to calculate the patient's ⁇ E is from exhalation and the at least one respiratory parameter used at step (c) to calculate the at least one estimate of P plt is from inspiration, characterized in that the at least one respiratory parameter used to calculate at least one estimate of P plt is from an inspiratory waveform at a single instance of time when respiratory effort is low, and wherein the single instance of
- the invention also provides a system for accurate and real time estimation of inspiratory plateau pressure "P plt " without using an end inspiratory pause (EIP), comprising: a device (5) configured to interface with a patient pulmonary system and measure respiratory parameters of a patient; a processor unit (20) configured to calculate an estimation of the patient's expiratory time constant " ⁇ E " using at least one respiratory parameter from the respiratory parameters of the patient; and where the processor unit (20) is further configured to calculate at least one estimate of P plt using the at least one respiratory parameter and the patient's ⁇ E , wherein the respiratory parameters to calculate the patient's ⁇ E is from exhalation and the at least one respiratory parameter to calculate the at least one estimate of P plt is from inspiration, wherein the system is configured such that at least one respiratory parameter used to calculate at least one estimate of P plt is from an inspiratory waveform at a single instance of time when respiratory effort is low, and wherein the system is configured to determine the single instance of time when respiratory effort is low by: (i) calculating P plt
- the at least one respiratory parameter used to calculate at least one estimate of P plt may be from an inspiratory waveform at a single instance of time taken at an early portion of the inspiratory waveform.
- the subject invention is particularly advantageous in that it can utilize commonly measured respiratory parameters (i.e., airway pressure and flow rate over time during inspiratory phase of mechanical ventilation) to generate accurate, real time estimates of pulmonary mechanics, including but not limited to P plt .
- the resultant pulmonary mechanics estimates are particularly useful in real time monitoring of patient reaction to mechanical ventilation mode changes, the effects of various interventions ( i.e., drugs) on pulmonary mechanics and physiology, the risks of lung overdistension, and the adequacy of lung protection strategies.
- Accurate and real time estimates of P plt are also useful during pressure regulated ventilation commonly utilized for weaning to assist spontaneous breathing.
- the method comprises creating a mathematical model of the patient's expiratory time constant ( ⁇ E ) of the respiratory system by using predetermined parameters that are collected non-invasively, such as those collected with standard respiratory monitors.
- parameters include, but are not limited to, exhalation volume, airflow rate and pressure.
- Respiratory monitors and ventilators typically contain airway pressure and airway flow sensors that measure the flow going into and out of the lungs, and often times they also contain a carbon dioxide sensor and pulse oximeter. From these time-waveforms, a variety of parameters are selectively derived that are used in characterizing different aspects of the patient's breathing and/or the patient's interaction with the ventilator. These parameters contain information that is extracted to accurately estimate the patient's inspiratory and expiratory flow and pressure waveform data. With the patient's inspiratory waveform data and ⁇ E , accurate and continuous calculation in real time of estimates of patient inspiratory P plt , and further patient C RS , R RS , and derivative pulmonary mechanics are accomplished. All of these estimates are useful for determining appropriate therapy, including ventilator settings.
- real time P plt , and patient C RS and R RS and derivative pulmonary mechanics are accurately and continuously estimated using ⁇ E from passive deflation of the lungs during all modes of breathing. More preferably, real time P plt , and patient C RS and R RS and derivative pulmonary mechanics, are accurately and continuously estimated using ⁇ E from passive deflation of the lungs during pressure regulated breathing.
- the method for calculating the pulmonary mechanics in a patient comprises use of a neural network, wherein the neural network provides the pulmonary mechanics information for the patient based upon input data, wherein the input data includes at least one of the following parameters: the airway pressure, flow, airway volume, expiratory carbon dioxide flow waveform, and pulse oximeter plethysmogram waveforms normally collected by a respiratory monitor, including but not limited to tidal volume, breathing frequency (f), PIP, inspiratory time, P 0.1 , inspiratory trigger time, trigger depth, wherein accurate and useful estimates for ⁇ E , P plt , C RS , and R RS are provided as an output variable.
- f breathing frequency
- the neural network is trained by clinical testing of a test population of patients to obtain teaching data, the teaching data which includes the above-noted input information.
- the teaching data are provided to the neural network, whereby the neural network is trained to provide an output variable corresponding to C RS , and R RS .
- the invention can be implemented in numerous ways, including as a system (including a computer processing or database system), a method (including a computerized method of collecting and processing input data and a method for evaluating such data to provide an output(s)), an apparatus, a computer readable medium, a computer program product, or a data structure tangibly fixed in a computer readable memory.
- a system including a computer processing or database system
- a method including a computerized method of collecting and processing input data and a method for evaluating such data to provide an output(s)
- an apparatus including a computer readable medium, a computer program product, or a data structure tangibly fixed in a computer readable memory.
- the subject invention includes processing predetermined input variables (parameters) using the formulas described herein, preferably through the use of a computer readable media program containing program instructions, a processing system, or a neural network.
- an embodiment of the invention includes: computer readable code devices for receiving input variables, processing the input, and providing an output indicative of C RS and R RS .
- processing comprises utilizing a neural network.
- the method may further include controlling a ventilator in response to the output obtained.
- the methods of the present invention may be implemented as a computer program product with a computer-readable medium having code thereon.
- the program product includes a program and a signal bearing media bearing the program.
- Inspiratory P plt is an important parameter to calculate a patient's C RS and R RS during mechanical ventilation. Monitoring P plt is also essential to avoid the over-distension of the alveoli, thus avoiding baro- and/or volutrauma, especially in patients with restrictive lung diseases (ARDS network protocol (July 2008); http://www.ardsnet.org/node/77791).
- the ⁇ E of passive lung exhalation is a parameterization of the time needed to complete exhalation based on an expontial decay and contains information about the mechanical properties of the respiratory system ( Guttmann, J. et al., "Time constant/volume relationship of passive expiration in mechanically ventilated ARDS patients," Eur Respir J., 8:114-120 (1995 ); and Lourens, MS et al., "Expiratory time constants in mechanically ventilated patients with and without COPD,” Intensive Care Med, 26(11): 1612-1618 (2000 )).
- ⁇ E is defined as the product of the C RS and R RS ( Brunner, JX et al., "Simple method to measure total expiratory time constant based on the passive expiratory flow volume curve," Crit Care Med, 23:1117-1122 (1995 )).
- FIGS. 13 and 14 are graphical illustrations of various respiratory parameters useful in calculating P plt , R RS and C RS .
- FIG. 13 shows a breath from variable patient effort while on pressure support ventilation (PSV) mode. The label shows the last point of inhalation on the airway pressure curve (Paw), which represents the least patient effort and is utilized to estimate P plt , R RS and C RS.
- PSV pressure support ventilation
- FIG. 15 shows a P plt curve, where P plt was calculated from ⁇ E estimates at every point of inhalation (and exhalation, which should be excluded).
- the label on the P plt curve is on the last valid portion of inhalation, which corresponds to the end of inhalation illustrated in FIG. 14 .
- the median of ⁇ E estimates utilizing the portion of exhalation where flow is less than 80% of peak inspiratory flow but greater than 0.1 LPS provide a more accurate estimate of ⁇ E .
- several estimates of the time constant for multiple breaths can be averaged or median filtered to provide a better estimate of ⁇ E for a region of breaths.
- the exhalation portion can be defined by percentage of volume exhaled.
- the median of ⁇ E estimates from different combinations of percentages of volume and/or peak expiratory flow provide more accurate estimates of ⁇ E .
- the percentage from the peak expiratory flow lies between 95% and 20% of the peak expiratory flow.
- the percentage from the peak expiratory flow lies between 95% and 70% of the peak expiratory flow.
- the portion of exhalation between 80% of exhaled volume and 20% of exhaled volume is utilized.
- ⁇ E values may vary with flow rate.
- better ⁇ E estimates can be achieved by selecting areas of exhalation to estimate ⁇ E based on the inspiratory flow rates. For example, better ⁇ E estimates can be achieved in those ventilation modes where the inspiratory flow rates are constant such as IMV, VC+ (Volume Control Plus), or Assist Control.
- the resistance portion of ⁇ E calculated in a mechanically ventilated patient is the sum of three series resistances i.e., total resistance (R TOT ), which is the sum of physiologic airways resistance (R aw ), imposed resistance of the endotracheal tube (R ETT ), and ventilator exhalation valve resistance (R vent ).
- R TOT R aw + R ETT + R vent
- the resistance applied by the ventilator exhalation valve can be excluded from the estimate of ⁇ E as derived above for improved, accurate modified estimates of ⁇ E .
- C RS and R RS and thus P plt , can be accurately estimated in accordance with the invention as follows:
- C RS Paw ⁇ PEEP V T + R RS ⁇ C RS ⁇ V inh : multiply both sides by C RS to derive the following equation for C RS :
- C RS V T + ⁇ E ⁇ V ⁇ in h P aw ⁇ PEEP
- P aw airway inflation pressure
- PEEP positive end expiratory pressure
- V T is tidal volume
- V inh is inspiratory flow rate.
- the flow, pressure, and volume values utilized are not waveforms, but are single measurements. In the preferred embodiment, these measurements occur simultaneously so that the volume, flow, and pressure values are associated with a single point in time during inhalation. Since the airway equation does not include a term for inspiratory effort generated by the patient's inspiratory muscles, the ideal location to measure these values is when the inspiratory effort is minimal (to avoid the errors caused by inspiratory effort in the airway equation). As such, the preferred point where these measurements are made are the point during inhalation with minimal effort. Locating the point of minimal patient effort, however, can be difficult because instantaneous patient effort can only be accurately calculated by invasive methods such as esophageal pressure catheters. In a typical breath, however, low patient effort often occurs near the end (or sometimes at the beginning) of inspiration.
- a point of minimum effort for accurate parameter estimation is determined by calculating P plt curves throughout inhalation and utilizing the point where P plt was at its maximum.
- a point of low patient effort is located by finding the position during inspiration where compliance is at its minimum value. Both of these embodiments rely on the fact that patient effort will tend to increase the estimate of compliance and decrease the plateau pressure.
- points A, B, and C in FIG. 16 provide examples of points of compliance that can be used to identify volume, flow and pressure values in calculating ⁇ E , P plt , R RS and C RS .
- FIG. 18 shows the resistance curve from the inhalation portion of this breath. Resistance is flow dependent, so as flow decreases, resistance will as well.
- breaths are contaminated by coughing, the patient fighting the ventilator, poor triggering by the ventilator, sensor noise or errors, and other problems.
- breaths that had a compliance value outside the normal range were eliminated.
- common breath parameters are computed and compared against normal values.
- the breath parameters include peak inspiratory pressure, tidal volume, inspiratory time, expiratory time, mean airway pressure, and the like.
- Contemplated ventilators include those that accomplish any one or more of the following modes of ventilation: volume-cycled ventilation; assist-control ventilation (A/C); synchronized intermittent mandatory ventilation (SIMV); pressure-cycled ventilation; pressure support ventilation (PSV); pressure control ventilation (PCV); noninvasive positive pressure ventilation (NIPPV); and continuous positive airway pressure (CPAP) or bilevel positive airway pressure (BIPAP).
- modes of ventilation volume-cycled ventilation; assist-control ventilation (A/C); synchronized intermittent mandatory ventilation (SIMV); pressure-cycled ventilation; pressure support ventilation (PSV); pressure control ventilation (PCV); noninvasive positive pressure ventilation (NIPPV); and continuous positive airway pressure (CPAP) or bilevel positive airway pressure (BIPAP).
- continuous, real time estimates of P plt , C RS , and R RS are determined in order to diagnose pulmonary condition or disease (including apnea detection and treatment in obstructive sleep apnea as well as COPD and ARDS detection) and/or to assess intervention efficacy.
- continuous accurate knowledge of patient C RS and R RS is particularly useful in establishing more accurate ventilator settings for the patient and in pharmaceutical applications (such as bronchodilators).
- Continuous and accurate knowledge of patient pulmonary mechanics during application of pharmaceuticals is particularly useful in assessing therapeutic efficacy and in determining proper dosage.
- the real-time data from this invention could be used to determine obstructions or obstacles from affecting the patient's ventilation.
- the invention can be utilized to determine when the breathing tube requires suctioning to remove mucus or other obstructions, or may determine when the tube may be kinked.
- real time estimates of P plt , C RS , and R RS are utilized to estimate or improve estimates of patient effort via the application of the airway equation (for example, calculating Pmus as the difference between the expected airway pressure and the actual airway pressure). This is also useful for determining and optimizing patient synchrony by allowing accurate measurement of the onset and offset of patient effort. Optimization of the ventilator on-triggering and off-triggering can be implemented either manually or automatically.
- the real time estimates are utilized to track the patient health and response to treatment. Compliance tracking during changes in PEEP indicate when the lung is being ventilated optimally. Changes in resistance indicate that drugs to relax the patient airway are working as expected. Utilizing the physiologic parameters allows for the titration and optimization of treatments, both via the ventilator and pharmaceutically.
- the model such as a neural network
- the input parameters can be collected non-invasively with a standard respiratory monitor.
- the neural network is trained to predict the physiologic and imposed pulmonary mechanics using the non-invasively acquired parameters described above (although invasive parameters may be added to the system, if desired.)
- the network output such as an actual pulmonary mechanics variable may be used as an accurate predictor of patient pulmonary mechanics.
- neural networks loosely model the functioning of a biological neural network, such as the human brain. Accordingly, neural networks are typically implemented as computer simulations of a system of interconnected neurons. In particular, neural networks are hierarchical collections of interconnected processing elements (PEs). These elements are typically arranged in layers, where the input layer receives the input data, the hidden layers transform the data, and the output layer produces the desired output. Other embodiments of a neural network can also be used.
- PEs processing elements
- Each processing element in the neural network receives multiple input signals, or data values, that are processed to compute a single output.
- the inputs are received from the outputs of PEs in the previous layer or from the input data.
- the output value of a PE is calculated using a mathematical equation, known in the art as an activation function or a transfer function that specifies the relationship between input data values.
- the activation function may include a threshold, or a bias element.
- the outputs of elements at lower network levels are provided as inputs to elements at higher levels. The highest level element, or elements, produces a final system output, or outputs.
- the neural network is a computer simulation that is used to produce a noninvasive estimate of the quantified patient effort described previously.
- the neural network of the present invention may be constructed by specifying the number, arrangement, and connection of the processing elements which make up the network.
- a simple embodiment of a neural network consists of a fully connected network of processing elements. As shown in FIG. 9 , the processing elements of the neural network are grouped into the following layers: an input layer 30 where the parameters collected and/or derived from the airway pressure and flow sensors are inputted to the network; a hidden layer or layers 32 of processing elements; and an output layer 34 where the resulting prediction of patient effort 36 is produced.
- the number of connections, and consequently the number of connection weights, is fixed by the number of elements in each layer 30, 32, 34.
- the most common training methodology for neural networks is based upon iterative improvement of the system parameters (normally called weights) by minimizing the mean squared difference between the desired output and the network output (mean squared error, MSE).
- MSE mean squared error
- the input is applied to the neural network, the neural network passes the data through its hierarchical structure, and an output is created. This network output is compared with the desired output corresponding to that input and an error is calculated. This error is then used to adjust the weights of the system so that the next time that particular input is applied to the system the network output will be closer to the desired output.
- MSE mean squared error
- the invention may be implemented using computer programming or engineering techniques including computer software, firmware, hardware or any combination or subset thereof. Any such resulting program, having computer-readable code means, may be embodied or provided within one or more computer-readable media, thereby making a computer program product, i.e., an article of manufacture, according to the invention.
- the computer readable media may be, for instance, a fixed (hard) drive, diskette, optical disk, magnetic tape, semiconductor memory such as read-only memory (ROM), etc., or any transmitting/receiving medium such as the Internet or other communication network or link.
- the article of manufacture containing the computer code may be made and/or used by executing the code directly from one medium, by copying the code from one medium to another medium, or by transmitting the code over a network.
- An apparatus for making, using or selling the invention may be one or more processing systems including, but not limited to, a central processing unit (CPU), memory, storage devices, communication links and devices, servers, I/O devices, or any sub-components of one or more processing systems, including software, firmware, hardware or any combination or subset thereof, which embody the invention.
- User input may be received from the keyboard, mouse, pen, voice, touch screen, or any other means by which a human can input data into a computer, including through other programs such as application programs.
- the subject systems and methods for accurately estimating in real time pulmonary mechanics based on monitored ventilation parameters was validated using a heterogenous population of thirty (30) adult patients in respiratory failure requiring mechanical ventilation, namely patients receiving positive pressure ventilation.
- FIG. 1 data from a combined pressure / flow sensor 5 (NICO, Respironics) positioned between the patient endotracheal tube 10 and Y-piece 15 of the ventilator breathing circuit, were directed to a laptop computer 20 with software performing the methods described herein (Convergent Engineering) for measurement and recording of pressure, flow, and volume data.
- NICO Pressure / flow sensor 5
- P plt data ranged from 10 to 44 cm H 2 0 in the studied patient population.
- Table 1 Patient Demographic Patient Age Height Weight Gender ETT size (mm) 1 74 62 68 male 7 2 37 68 62 male 8 3 37 74 204 male 7.5 4 53 71 108 male 8 5 67 64 60 male 7 6 69 70 71 male 8 7 68 65 68 female 8 8 51 72 80 male 8 9 37 66 69 male 8 10 67 72 83 male 8 11 20 73 223 male 8 12 62 59 60 female 7 13 73 68 89 male 8 14 18 67 60 female 7 15 60 70 60 male x 16 20 64 62 male 7.5 17 50 70 63 male 8 18 54 70 80 male 7.5 19 68 65 50 female 7.5 20 48 72 76 male 8 21 47 69 66 male 7.5 22 26 71 74 male 8 23 48 72 76 male 8 24 72 74 90 male 8 25 75 65 76 male 7.5 26 18 73 100 male 8 27 63 69 70 male 7.5 28 50 67 75 female 7.5 29 25 71 86 male 8 30 70 72 83 male 8
- ⁇ E was obtained from three random patients (A, B and C) with three different inhalational flows (0.5, 0.75 and 1 L/S) and compared with ⁇ E P plt obtained by an end inhalation pause (EIP).
- EIP end inhalation pause
- ⁇ E P plt differs from ⁇ E depending on the gap between PIF and PEF (X-axis).
- ⁇ E is represented in FIGS. 4A-4C as blue diamonds and ⁇ E P plt as red squares, where the difference in ⁇ E P plt from ⁇ E is represented as green triangles.
- PIF-PEF then becomes the correction factor for ⁇ E ( Guerin, C. et al., "Effect of PEEP on work of breathing in mechanically ventilated COPD patients," Intensive Care Med, 26(9): 1207-1214 (2000 ).
- the 24 adults consisted of 10 males and 14 females with ranges in age 56.1 ⁇ 16.6 yrs and weight 79.9 ⁇ 28.8 kg. They had heterogeneous causes of respiratory failure and were breathing spontaneously with PSV.
- PSV ranged between 5 and 20 cm H 2 O.
- PSV and IMV with EIP were compared in the same patients.
- P plt and C RS were obtained by integrating the ⁇ E from the expiratory volume and flow waveforms.
- IMV and EIP P plt was obtained from viewing pressure plateau of the airway pressure waveform at EIP. Data were analyzed using regression and Bland-Altman analysis; alpha was set at .05.
- P plt and C RS from the ⁇ E method were 19.65 ⁇ 6.6 cm H 2 O and 0.051 ⁇ 0.0124 ml / cm H 2 O, respectively.
- Bland-Altman plots for P plt and C RS showed bias at 1.17 and - 0.0035, respectively and precision at ⁇ 1 and ⁇ 0.0031, respectively.
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Claims (10)
- Verfahren zur genauen und Echtzeitschätzung des inspiratorischen Plateaudrucks "Pplt" ohne Verwendung einer endinspiratorischen Pause (EIP), umfassend:(a) Empfangen von respiratorischen Parametern eines Patienten von einer Vorrichtung (5), die mit dem Lungensystem eines Patienten verbunden ist und die respiratorischen Parameter misst;(b) Berechnen der exspiratorischen Zeitkonstante "TE" des Patienten mit einer Prozessoreinheit (20) unter Verwendung mindestens eines respiratorischen Parameters aus Schritt (a); und(c) Berechnen mindestens einer Schätzung von Pplt mit der Prozessoreinheit (20) unter Verwendung mindestens eines respiratorischen Parameters aus Schritt (a) und der TE des Patienten aus Schritt (b),wobei die respiratorischen Parameter, die in Schritt (b) zum Berechnen der TE des Patienten verwendet werden, aus der Ausatmung stammen und der mindestens eine respiratorische Parameter, der in Schritt (c) zur Berechnung der mindestens einen Schätzung von Pplt verwendet wird, aus der Einatmung stammt, wobei der mindestens eine respiratorische Parameter, der zum Berechnen von mindestens einer Schätzung von Pplt verwendet wird, aus einer inspiratorischen Wellenform zu einem einzelnen Zeitpunkt stammt, wenn die Atemleistung gering ist, und wobei der einzelne Zeitpunkt, zu dem die Atemleistung gering ist, bestimmt wird durch:(i) Berechnen von Pplt-Kurven während der Einatmung und Verwenden des Punktes, an dem Pplt am Maximum war, oder(ii) Berechnung der Compliance des respiratorischen Systems "CRS" während der Einatmung und Nutzung des Punktes, an dem CRS am Minimum war.
- Verfahren nach Anspruch 1, wobei der mindestens eine respiratorische Parameter, der zum Berechnen mindestens einer Schätzung von Pplt verwendet wird, aus einer inspiratorischen Wellenform zu einem einzelnen Zeitpunkt stammt, der in einem frühen Abschnitt der inspiratorischen Wellenform genommen wird.
- Verfahren nach Anspruch 1, wobei die respiratorischen Parameter einen oder mehrere aus der Gruppe enthalten, bestehend aus: inspiratorischem und exspiratorischem Atemwegsdruck, inspiratorischer und exspiratorischer Flussrate, Atemwegsvolumen, Atemwegswiderstand, exspiratorischer Kohlendioxidflusswellenform, Pulsoximeter-Plethysmogramm-Wellenformen, Tidalvolumen, Atemfrequenz "f", inspiratorischem Spitzendruck (Peak Inspiratory Pressure) "PIP", Inspirationszeit "P0.1", inspiratorischer Triggerzeit und Triggertiefe.
- Verfahren nach Anspruch 1, ferner umfassend das Anwenden eines Korrekturfaktors auf die TE des Patienten, und Verwenden einer Gleichung zum Berechnen mindestens einer Schätzung von Pplt, wobei die Gleichung Pplt = (VT * Paw - VT * PEEP) / ((VT + TE * Vinh) + PEEP) umfasst, wobei VT das Tidalvolumen ist, PEEP der positive endexspiratorische Druck ist, Paw der Atemwegsdruck ist und Vinh die inspiratorische Flussrate ist.
- Verfahren nach Anspruch 1, wobei die berechnete mindestens eine Schätzung von Pplt in einer oder mehreren der folgenden Funktionen verwendet wird: Bestimmen der Überdehnung oder des Überdrucks während der mechanischen Beatmung und Bestimmen der resultierenden Schätzungen für die Compliance des respiratorischen Systems "CRS" und des Atemwegswiderstands des Patienten "RRS".
- Verfahren nach Anspruch 1, wobei die TE des Patienten unter Verwendung einer exspiratorischen Wellenform nur während des mittleren Abschnitts der Ausatmung berechnet wird.
- System zur genauen und Echtzeitschätzung des inspiratorischen Plateaudrucks "Pplt" ohne Verwendung einer endinspiratorischen Pause (EIP), umfassend:eine Vorrichtung (5), die konfiguriert ist, um eine Schnittstelle mit einem Lungensystem des Patienten herzustellen und respiratorische Parameter eines Patienten zu messen;eine Prozessoreinheit (20), die konfiguriert ist, um eine Schätzung der exspiratorischen Zeitkonstante "TE" des Patienten unter Verwendung mindestens eines respiratorischen Parameters aus den respiratorischen Parametern des Patienten zu berechnen; undwobei die Prozessoreinheit (20) ferner konfiguriert ist, um mindestens eine Schätzung von Pplt unter Verwendung des mindestens einen respiratorischen Parameters und der TE des Patienten zu berechnen, wobei die respiratorischen Parameter zur Berechnung der TE des Patienten aus der Ausatmung stammen und der mindestens eine respiratorische Parameter zur Berechnung der mindestens einen Schätzung von Pplt aus der Einatmung stammt, wobei das System derart konfiguriert ist, dass der mindestens eine respiratorische Parameter, der zum Berechnen von mindestens einer Schätzung von Pplt verwendet wird, aus einer inspiratorischen Wellenform zu einem einzelnen Zeitpunkt stammt, wenn die Atemleistung gering ist, und wobei das System ferner konfiguriert ist, um den einzelnen Zeitpunkt, zu dem die Atemleistung gering ist, zu bestimmen durch:(i) Berechnen von Pplt-Kurven während der Einatmung und Verwenden des Punktes, an dem Pplt am Maximum war, oder(ii) Berechnung der Compliance des respiratorischen Systems "CRS" während der Einatmung und Nutzung des Punktes, an dem CRS am Minimum war.
- System nach Anspruch 7, wobei der mindestens eine respiratorische Parameter, der zum Berechnen mindestens einer Schätzung von Pplt verwendet wird, aus einer inspiratorischen Wellenform zu einem einzelnen Zeitpunkt stammt, der in einem frühen Abschnitt der inspiratorischen Wellenform genommen wird.
- System nach Anspruch 7, wobei die respiratorischen Parameter einen oder mehrere aus der Gruppe enthalten, bestehend aus: inspiratorischem und exspiratorischem Atemwegsdruck, inspiratorischer und exspiratorischer Flussrate, Atemwegsvolumen, Atemwegswiderstand, exspiratorischer Kohlendioxidflusswellenform, Pulsoximeter-Plethysmogramm-Wellenformen, Tidalvolumen, Atemfrequenz "f", inspiratorischem Spitzendruck (Peak Inspiratory Pressure) "PIP", Inspirationszeit "P0.1", inspiratorischer Triggerzeit und Triggertiefe.
- System nach Anspruch 7, ferner umfassend die Prozessoreinheit (20), die konfiguriert ist, um einen Korrekturfaktor auf die TE des Patienten anzuwenden und mindestens eine Schätzung von Pplt zu berechnen, wobei die Gleichung Pplt = (VT * Paw - VT * PEEP) / ((VT + TE * Vinh) + PEEP) umfasst, wobei VT das Tidalvolumen ist, PEEP der positive endexspiratorische Druck ist, Paw der Atemwegsdruck ist und Vinh die inspiratorische Flussrate ist.
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PCT/US2010/062232 WO2011090716A2 (en) | 2009-12-28 | 2010-12-28 | System and method for assessing real time pulmonary mechanics |
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BR112012016102B1 (pt) | 2020-11-03 |
US8728002B2 (en) | 2014-05-20 |
WO2011090716A2 (en) | 2011-07-28 |
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US20120330177A1 (en) | 2012-12-27 |
JP2013515592A (ja) | 2013-05-09 |
CN102770070A (zh) | 2012-11-07 |
EP3391816A1 (de) | 2018-10-24 |
JP5858927B2 (ja) | 2016-02-10 |
JP6564318B2 (ja) | 2019-08-21 |
CN102770070B (zh) | 2015-11-25 |
EP2519151A2 (de) | 2012-11-07 |
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WO2011090716A3 (en) | 2011-09-22 |
JP2016104154A (ja) | 2016-06-09 |
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