EP3342486B1 - Dispositifs et procédés d'exposition aux aérosols - Google Patents

Dispositifs et procédés d'exposition aux aérosols Download PDF

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Publication number
EP3342486B1
EP3342486B1 EP17001888.1A EP17001888A EP3342486B1 EP 3342486 B1 EP3342486 B1 EP 3342486B1 EP 17001888 A EP17001888 A EP 17001888A EP 3342486 B1 EP3342486 B1 EP 3342486B1
Authority
EP
European Patent Office
Prior art keywords
aerosol
container
dosing
metering
fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP17001888.1A
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German (de)
English (en)
Other versions
EP3342486A2 (fr
EP3342486A3 (fr
Inventor
Krebs Tobias
Heilemann Sascha
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PIETER VAN WEENEN and CO GmbH House of Innovation
Original Assignee
PIETER VAN WEENEN and CO GmbH House of Innovation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Publication of EP3342486A2 publication Critical patent/EP3342486A2/fr
Publication of EP3342486A3 publication Critical patent/EP3342486A3/fr
Application granted granted Critical
Publication of EP3342486B1 publication Critical patent/EP3342486B1/fr
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
    • B65D83/38—Details of the container body
    • B65D83/388—Details of the container body with means for suspending the aerosol container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B15/00—Details of spraying plant or spraying apparatus not otherwise provided for; Accessories
    • B05B15/20—Arrangements for agitating the material to be sprayed, e.g. for stirring, mixing or homogenising
    • B05B15/25—Arrangements for agitating the material to be sprayed, e.g. for stirring, mixing or homogenising using moving elements, e.g. rotating blades
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/02—Spray pistols; Apparatus for discharge
    • B05B7/04—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge
    • B05B7/0416—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid
    • B05B7/0483—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid with gas and liquid jets intersecting in the mixing chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
    • B65D83/16—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant characterised by the actuating means
    • B65D83/26—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant characterised by the actuating means operating automatically, e.g. periodically
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
    • B65D83/38—Details of the container body
    • B65D83/384—Details of the container body comprising an aerosol container disposed in an outer shell or in an external container
    • B65D83/386—Details of the container body comprising an aerosol container disposed in an outer shell or in an external container actuation occurring by moving the aerosol container relative to the outer shell or external container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
    • B65D83/72—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant with heating or cooling devices, e.g. heat-exchangers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B13/00—Machines or plants for applying liquids or other fluent materials to surfaces of objects or other work by spraying, not covered by groups B05B1/00 - B05B11/00
    • B05B13/02—Means for supporting work; Arrangement or mounting of spray heads; Adaptation or arrangement of means for feeding work
    • B05B13/04—Means for supporting work; Arrangement or mounting of spray heads; Adaptation or arrangement of means for feeding work the spray heads being moved during spraying operation
    • B05B13/0421—Means for supporting work; Arrangement or mounting of spray heads; Adaptation or arrangement of means for feeding work the spray heads being moved during spraying operation with rotating spray heads

Definitions

  • the present invention relates to devices and methods for dispensing aerosol, for example in the context of investigations of biological samples which are to be exposed to an aerosol.
  • aerosols biological effect and activity of airborne substances, gases, mixtures etc. (hereinafter referred to as aerosols) on biological cells, for example in the human or animal respiratory system, is examined. This can be done by exposing a biological sample to be examined to an aerosol, for example arranged on a membrane.
  • the US 7,185,648 B1 discloses an aerosol dosing container which has one or more stirring elements in its aerosol receiving space, which can be moved by means of a drive relative to the inside of the aerosol receiving space in order to mix aerosol present in the aerosol receiving space.
  • the object of the present invention is to provide solutions which simplify and improve investigations in which a sample is exposed to an aerosol.
  • the stirring element is connected to the aerosol container or the container closure, whereby a movement of the aerosol dosing container as a whole can lead to a relative movement between the stirring element and the aerosol.
  • a positive and / or frictional drive element is arranged on an outside of the aerosol container in order to move the aerosol dosing container relative to the aerosol contained therein.
  • the at least one stirring element can have at least one stirring element extending in a direction parallel and / or perpendicular to a longitudinal axis of the aerosol container.
  • the at least one stirring element can be arranged on an inside of the aerosol container and / or on the container closure.
  • the at least one stirring element can have at least two stirring elements, which can be arranged on an inner side of the aerosol closure and / or can extend in a direction parallel to the longitudinal axis of the aerosol container.
  • the at least one stirring element can be formed on an insert arranged in the aerosol receiving space.
  • a magnetic stirring fish that can be moved in the aerosol receiving space can be provided.
  • the magnetic stirrer fish can be designed as a stir bar, cross stirrer, triangular stirrer or tablet stirrer or the like.
  • the drive element can comprise an annular and / or elongate element, which can have a toothed outside.
  • An annular element with a toothed outside can e.g. be a gear or toothed ring.
  • An elongated element with a toothed outside can e.g. be a rack to move the dosing container in the direction of its longitudinal axis (up / down).
  • An aerosol metering arrangement is also disclosed.
  • the movement device can comprise a positive and / or frictional driven element, which can serve for the operative connection with the positive and / or frictional drive element of the aerosol dosing container.
  • the output element can comprise an annular and / or elongate element, which can have a toothed outside.
  • a ring-shaped element with a toothed outside can be a gearwheel which can interact with the gearwheel ring or the toothed rack of the metering container.
  • An elongated element with a toothed outside can be a toothed rack which can interact with the gear ring or the toothed rack of the metering container
  • the actuating device can have a movable actuating element which can be movable in a direction towards a bottom of an aerosol dosing container arranged in the dosing container holder.
  • the aerosol metering arrangement can comprise a fluid supply device which can be used to supply fluid into aerosols dispensed from the aerosol metering container.
  • the aerosol metering arrangement can comprise at least one heating and / or cooling device.
  • a heating and / or cooling device can be arranged in an area below the metering container holder.
  • a heating and / or cooling device can be arranged in and / or on the metering container holder.
  • a device using heated and / or cooled fluid e.g. water, air
  • a device using electrically operating device can be used as the heating and / or cooling device.
  • An aerosol metering system is also disclosed.
  • the at least one stirring element is connected to the aerosol dosing container. To move the at least one stirring element relative to the aerosol, the aerosol dosing container can be moved.
  • a predetermined amount of aerosol can be dispensed from the aerosol dosing container.
  • the step of dispensing a predetermined amount of aerosol from the aerosol dosing container can be carried out after or before the step of moving the at least one stirring element relative to the aerosol.
  • the steps of dispensing a predetermined amount of aerosol from the aerosol dosing container and moving the at least one stirring element relative to the aerosol can be repeated in this order or in reverse order or in alternating order at least twice at predetermined and / or different time intervals.
  • a predetermined amount of fluid can be fed into the aerosol dispensed from the aerosol dosing container.
  • a predetermined amount of fluid can be removed from the aerosol dispensed from the aerosol dosing container.
  • the drawings show an aerosol metering arrangement, generally designated 2, and an exposure module, generally designated 4.
  • the exposure module 4 has one or more sample receiving areas 6, in which biological samples 10 to be examined can be arranged, for example, by means of so-called inserts 8 (e.g. inserts referred to as Transwell®).
  • inserts 8 e.g. inserts referred to as Transwell®
  • nutrient solution 12 for the samples 10 is present below the inserts 8.
  • a sedimentation tube 14 is assigned to each of the sample receiving areas 6, each defining a sedimentation channel 16 that extends between a sedimentation channel outlet 18, which is opposite the respective sample 10, and a sedimentation channel inlet 20, which ends at the end opposite the sedimentation channel outlet 18 lies. Aerosol can be supplied to the respective samples 10 via the sedimentation tubes 14 or through the sedimentation channels 16.
  • the sedimentation tubes 16 can each have a suction opening 22 which provides a fluid connection to the respective sedimentation channel 16. Gaseous components which, for example, are not intended to reach the samples, can be removed via the suction openings 22 from the aerosol flowing through and / or sinking into the respective sedimentation channel 16.
  • the suction openings 22 can each be connected to a suction line 24, which in turn lead to a suction device 26 (for example a pump). (please refer Fig. 4a )
  • a suction pipe 28 (see Fig. 4b and 4c ) are introduced into the respective sedimentation channel 16. In this way, for example, fluid can be sucked off / removed at a predetermined location or area in the sedimentation channel 16.
  • the suction pipe 28 can be guided down (just about) over the surface of a sample 10.
  • the suction tube 28 can be cannula-like, for example.
  • the aerosol metering arrangement 2 comprises one or more metering container holders 30, in each of which an aerosol metering container 32 can be arranged. Preferably corresponds the number of dosing container holders 30 the number of sample receiving areas 6.
  • a dosing container holders 30 and components of the aerosol dosing arrangement 2 used therewith are described below. The statements made with respect to a metering container holder 30 apply accordingly to any further, unless otherwise stated.
  • the dosing container holder 30 comprises a sleeve 34 in which an aerosol dosing container 32 can be received.
  • a non-positive operative connection between the outside of the aerosol dosing container 32 and the inside of the sleeve 34 can be provided. This can be done for example by means of an O-ring 36 at the upper end of the sleeve 34 as shown.
  • the metering container holder 30 also has a drive device 38, which according to the drawings comprises a sleeve 40 arranged on the outside of the sleeve 34 and a drive element 42 arranged on the outside of the sleeve 40.
  • the drive element 42 can be arranged directly on the sleeve 34.
  • the drive element 42 has an outer circumferential surface 44 which is designed for a non-positive and / or positive connection with a correspondingly designed output element 46, which is described below.
  • the outer circumferential surface 44 can have a toothed surface in order to transmit forces and / or movements of an output element 46, which also has a toothing, from the latter to the drive element 42 in order to move the drive element 42 (e.g. rotationally and / or translationally).
  • the drive element 42 can also be referred to as a toothed wheel.
  • the outer circumferential surface 44 can have a surface that is suitable, for example, by coating and / or because of its material, so that forces and / or movements of an output element 46 can be transmitted to the drive element 42 and thus the drive device 38 by frictional engagement in order to move it ( eg rotational and / or translational).
  • the drive element 42 can also be referred to as a friction wheel.
  • movements of the drive device 38 can be transmitted to the sleeve 34 and an aerosol dosing container 32 arranged therein.
  • the drive device 38 and thus the sleeve 34 and an aerosol dosing container 32 arranged therein are supported and movable by means of a device 50.
  • the device 50 can have one or more ball bearings 50, the outer ring of which are connected to the main holder body 48 and the inner ring of which is connected to the sleeves 34 and / or the sleeve 40.
  • the aerosol metering arrangement 2 further comprises a drive device 52 which has an output element 46 which is provided for the operative connection with the drive device 38 and which serves to drive the drive device 38.
  • the output element 46 has an outer peripheral surface 54 which is designed for a non-positive and / or positive connection with a correspondingly configured drive element 42 (see above).
  • the outer peripheral surface 42 may have a toothed surface.
  • the output element 46 can also be referred to as a toothed wheel.
  • the outer peripheral surface 54 may have a surface that e.g. by coating and / or due to its material, so that forces of the output element 46 can be transmitted to a drive element 42 and thus a drive device 38 by frictional engagement in order to move them (e.g. rotationally and / or translationally).
  • the driven element 46 can also be referred to as a friction wheel.
  • the drive device 52 comprises a controllable drive 56, for example an electric motor, which is preferably designed or can be operated as a stepper motor.
  • the output shaft 58 of the drive 56 can be connected directly or by means of a transmission / gearbox to the output element 46 in order to transmit rotations of the output shaft 58 1: 1 or step-down or reduced to the output element 46.
  • the drive 56 is connected to a controller ST via a wired and / or wireless connection V.
  • the connection V can also be designed to supply the drive 56 with energy.
  • a separate energy supply or an energy supply can be provided, which is arranged in or on the aerosol metering arrangement 2.
  • the drive devices 38 and 52 can be designed to translate an aerosol dosing container 32 in one direction essentially parallel to its longitudinal axis as shown.
  • the drive element 42 can e.g. be designed as an elongated drive element extending in a direction parallel to the longitudinal axis of the sleeve 34 or an aerosol dosing container 32 arranged therein.
  • an elongated toothed rack and / or friction surface and / or coating on the outside of the sleeve 34 (or the sleeve 40) extending in the longitudinal direction thereof can be used.
  • a gearwheel or friction wheel can also be used here as the drive element 46, which can be operated in a controlled manner by means of the controlled drive 56 in order to move an aerosol dosing container 32 in a desired manner in a translatory manner (upward and / or downward as shown).
  • a common drive device 52 can be used for a plurality of metering container holders 30 or their drive devices 38, which e.g. has a shared drive 56 and for the various dosing container holders 30 or their drive devices 38 each has an output element 46.
  • the aerosol metering arrangement 2 has an actuating device 60 which comprises a selectively controllable, movable actuating element 62.
  • the actuating element 62 can be moved pneumatically, for example by means of an electric or hydraulic drive or, as shown, via pneumatic connections 64 and 66.
  • the actuating element 62 can be moved in the direction of the arrow 68 towards an aerosol dosing container 32 in order to contact it and thereby actuate it, as explained further below. By moving the actuating element 62 against the direction of arrow 68, the operative connection with the aerosol dosing container 32 and thus its actuation can be terminated.
  • the aerosol metering arrangement 2 can have a cover 72 which can be assigned by means of a joint / swivel mechanism 70.
  • a cover 72 which can be assigned by means of a joint / swivel mechanism 70.
  • aerosol containers 32 can be introduced into metering container holders 30 or removed therefrom.
  • the lid 72 is closed (see 1a and 1b ) Aerosol dosing containers 32 arranged in the dosing container holders 30 can be operated by means of the actuating device 60 and can be moved by means of the drive devices 38 and 52.
  • the aerosol metering arrangement 2 can comprise a heating and / or cooling device 74, which can have channels 76, for example, through which heated and / or cooled fluid (e.g. heated / cooled water, air) can be guided.
  • heated and / or cooled fluid e.g. heated / cooled water, air
  • the aerosol metering arrangement 2 can comprise a further heating and / or cooling device, which is integrated, for example, in the metering container holder 30 (there, for example, arranged in / on the sleeve 34) to an aerosol metering container 32 arranged there to a predetermined temperature or to bring or keep it in a certain temperature range.
  • the aerosol metering arrangement 2 can comprise a fluid supply device 78.
  • the fluid supply device 78 can serve to introduce fluid, in particular air or another gas, into aerosol flowing through and / or sinking through a sedimentation channel 16.
  • the fluid supply device 78 has one or more supply lines 80 which can be connected to a preferably controllable fluid source 82 which can supply the desired fluid and comprises, for example, a pump.
  • the fluid source 82 can also be used together for several sedimentation tubes 14.
  • a fluid supply device 78 also has inlet channels 84, which extend from a corresponding one of the supply lines 80 to a sedimentation tube 14.
  • the sedimentation tubes 14 have openings 86 adjacent to the respective sedimentation channel inlet 20.
  • the free ends of the inlet channels 84, where fluid to be introduced into sedimentation channels 16 can escape, can protrude into the openings 86 or are at least slightly spaced from the openings 86 that fluid can be introduced into the openings 86 and thus into sedimentation channels 16.
  • Such variants make it possible to use the aerosol metering arrangement 2 different types of exposure modules.
  • outlets of the inlet channels 84 and / or the sedimentation tubes 14 can be configured such that fluid can be introduced directly into the sedimentation channel inlets 20.
  • the inlet channels 84 can be connected to the openings 86 or connected to them.
  • An aerosol dosing container 32 comprises an aerosol container 88, which defines an aerosol receiving space 90 and has an aerosol container opening 92.
  • the aerosol container 88 is closed in a fluid-tight manner by means of a container closure 94 attached to the aerosol container opening 92.
  • the container closure 94 comprises a metering valve 96 which, when actuated, releases or transmits a predetermined amount of aerosol contained in the aerosol container 88 via a movable valve outlet 98.
  • the metering valve 96 can be designed in such a way that it is opened by an actuation and closes automatically after a predetermined period of time. Alternatively, the metering valve 96 can be designed in such a way that it is opened by an actuation as long as it remains open, as long as the actuation continues and only closes when the actuation is ended.
  • a metering valve 96 is provided which can be actuated by ensuring a relative movement between metering valve 96 (and in particular its valve outlet 98) and aerosol container 88.
  • the valve outlet 98 of the metering valve 96 contacts the end of a sedimentation tube 14 with the sedimentation channel inlet 20 (or another element which serves as a stop), as a result of which the valve outlet 98 no longer follows the movement of the aerosol container 88 and this occurs Dosing valve 96 opens.
  • the duration of the opening of the metering valve 96 can be controlled by controlling the movement and positioning of the actuating element 62.
  • Aerosol in the aerosol dosing container 32 can comprise particles and gas, in particular propellant gas. During storage and also when arranged in a dosing container holder 30, sedimentation of particles contained in the aerosol can occur in the aerosol dosing container 32 come. This means that the aerosol in the aerosol dosing container 32 does not have a homogeneous, uniform composition (anymore).
  • one or more stirring elements 102 are provided in the aerosol container 88.
  • One or more stirring elements 102 can be arranged on the inside of the container closure 94 and extend from this into the aerosol receiving space 90; preferably in the longitudinal direction of the aerosol container 88 and / or at a slight angle thereto.
  • three stirring elements of the same or different lengths, also with bevelled ends, can be used. (please refer Fig. 9-12 ).
  • one or more stirring elements 102 can also be provided, which, starting from the inside on the bottom 100 of the dosing container 88, extend inwards into the aerosol receiving space 90; preferably in the longitudinal direction of the aerosol container 88 and / or at a slight angle thereto.
  • three stirring elements of the same or different lengths, also with bevelled ends, can be used, for example (see Fig. 13 ).
  • one or more stirring elements 102 can also be provided, which, starting from an inner lateral surface 104 of the dosing container 88, extend inwards into the aerosol receiving space 90; preferably transverse to the longitudinal direction of the aerosol container 88 and / or at a slight angle thereto.
  • three stirring elements of the same or different lengths can be used, even with bevelled ends. (please refer Fig. 14 )
  • stirring elements 102 which can move freely in the aerosol receiving space 90 (see FIG. Fig. 15-16 ).
  • Such stirring elements 102 can be partially magnetic.
  • Stirrer elements 102 that are not freely movable can be attached to the inside of the container closure 94 and / or the inside of the bottom 100 and / or the inner lateral surface 104 of the dosing container 88.
  • stirring elements 102 which are not freely movable can be attached and / or formed on an insert E which can be introduced into the dosing container 88.
  • stirring elements 102 which are not freely movable can be provided by correspondingly shaping the inside of the dosing container 88.
  • the function of the stirring elements 102 is to stir in the aerosol or to mix its components in order to ensure a homogeneous mixing / distribution of aerosol components, particularly after sedimentation.
  • Mixing by means of the stirring elements 102 can be achieved by moving them relative to the aerosol contained in the aerosol container 88.
  • Such movement of an aerosol dosing container 32 can be achieved by manually moving the aerosol dosing container 32.
  • the movement can be achieved by means of the drive devices 38 and 52.
  • the mixing can be achieved by means of the stirring elements 102 if freely moving stirring elements 102 are present in the aerosol receiving space.
  • the freely moving stirring elements 102 (at least initially) will not move, which leads to a relative movement to the aerosol in the aerosol container 88 or its components.
  • stirring elements 102 can be used, which are partially magnetic. Such more magnetic elements 102 can be moved by means of an externally applied magnetic field in order to stir in the aerosol or to mix its components, as in the case of a magnetic stirrer. With aerosol dosing container 32 this can be done per se if a corresponding magnetic field is applied to an aerosol dosing container 32.
  • the aerosol metering arrangement includes 2 shows a magnetic field generating device which can generate a magnetic field in order to move magnetic stirring elements 102 in an aerosol receiving space.
  • Samples 10 are arranged in the exposure module 4 and the exposure module 4 is positioned below the aerosol metering arrangement, as illustrated in the drawings.
  • the cover 72 thereof is opened, whereby the aerosol dosing containers 32 can be inserted into container holders 30 and held there securely.
  • the lid 72 is then closed. This positions the actuating devices 60 with respect to the aerosol dosing container 32 such that the respective dosing valves 96 can be actuated by means of the corresponding actuating elements 62, as described above.
  • the drive device 52 In order to rotate the aerosol dosing containers 32, as described above, in order to mix components of aerosols contained in the respective aerosol container 88 by means of stirring elements 102 present in them, the drive device 52 is operated in a controlled manner in such a way that the aerosol dosing containers 32 in be rotated as desired. It is possible to specify in a controlled manner how long, how often, how fast and / or in which direction the rotation should take place. This can be specified jointly or individually for the different aerosol dosing containers 32.
  • Such a mixing process can take place before each delivery of aerosol from the aerosol metering containers 32 by actuating the respective metering valve 96, even before the first one.
  • the mixing processes with respect to the different aerosol dosing containers 32 can take place simultaneously, with a time delay, overlapping etc.
  • the corresponding aerosol dosing containers 32 are actuated by means of the respective actuating device 60, as described above. It is possible to specify in a controlled manner how long, how often, and / or how quickly an operation should take place in each case. This can be specified jointly or individually for the different aerosol dosing containers 32.
  • the respective metering valve 96 releases a certain amount of aerosol, which reaches the respective sample via a corresponding sedimentation channel.
  • fluid e.g. air
  • the respective (or possibly common) fluid supply device 78 can be introduced into the corresponding sedimentation channel via the respective (or possibly common) fluid supply device 78, for example in order to dilute the aerosol.
  • fluid e.g. air, propellant gas
  • suction opening 22 can be removed from the corresponding sedimentation channel via the respective suction opening 22, for example in order to prevent undesirable effects on the respective sample 10.
  • the aerosol can be dispensed once, several times and until the aerosol is no longer available or is no longer available in such an amount that the predetermined amount of aerosol can be dispensed.
  • One or more mixing processes (“turning aerosol dosing containers”) can be carried out between each or after a predetermined number of aerosol deliveries.
  • the cover 72 is opened in order to remove the aerosol dosing containers 32 and, if necessary, to replace them with others.
  • REFERENCE SIGN LIST REFERENCE SIGN LIST
  • Aerosol dosing arrangement 2nd Exposure module 4th Sampling area 6 Insert 8th sample 10th Nutrient solution 12th Sedimentation tube 14 Sedimentation channel 16 Sedimentation channel outlet 18th Sedimentation channel inlet 20 Suction opening 22 Suction line 24th Suction device 26 Exhaust pipe 28

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  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

Claims (12)

  1. Récipient de dosage d'aérosol (32) pour la distribution dosée d'aérosol, comprenant:
    - un récipient d'aérosol (88) destiné à contenir un aérosol, ledit récipient d'aérosol définissant un espace de réception d'aérosol (90) et ayant une ouverture de récipient d'aérosol (92),
    - une fermeture de récipient (94) prévue pour la fermeture étanche aux fluides de l'ouverture (92) du récipient d'aérosol, ladite fermeture de récipient comprenant une valve de dosage actionnable (96) pour la distribution dosée de l'aérosol contenu dans l'espace de réception d'aérosol (90),
    - au moins un élément agitateur (102) qui s'étend dans l'espace de réception de l'aérosol et est relié de manière fixe à un côté intérieur du récipient d'aérosol (88) et/ou à la fermeture du récipient (94),
    dans lequel un élément d'entraînement (42) à engagement positif et/ou à friction est disposé sur un côté extérieur du récipient à aérosol (88) afin de déplacer le récipient de dosage d'aérosol (32) par rapport à l'aérosol contenu dans celui-ci, de sorte que, lorsque le récipient de dosage d'aérosol (32) est déplacé, au moins un élément d'agitation (102) se déplace par rapport à l'aérosol contenu dans l'espace de réception d'aérosol afin de le remuer.
  2. Récipient de dosage d'aérosol selon la revendication 1, dans lequel au moins un élément d'agitation (102) présente au moins un élément d'agitation (120) s'étendant dans une direction parallèle et/ou perpendiculaire à un axe longitudinal du récipient d'aérosol (88).
  3. Récipient doseur d'aérosol selon la revendication 1 ou 2, dans lequel
    - le ou les éléments agitateurs sont disposés dans le récipient aérosol (88) au moyen d'un insert disposé dans l'espace de réception de l'aérosol.
  4. Récipient de dosage d'aérosol selon l'une des revendications précédentes, comprenant en outre un poisson à agitation magnétique disposé de manière mobile dans l'espace de réception de l'aérosol.
  5. Dispositif de dosage des aérosols, comprenant :
    - un récipient de dosage d'aérosol (32) selon l'une des revendications précédentes 1 à 4,
    - un support de récipient de dosage (30) permettant de disposer le récipient de dosage d'aérosol (32) pour la distribution dosée de l'aérosol en actionnant la valve de dosage (96) du récipient de dosage d'aérosol (32),
    - un dispositif d'actionnement (60) pour actionner la valve de dosage (96) du récipient de dosage d'aérosol (32),
    - un dispositif de déplacement contrôlable pour déplacer le récipient de dosage d'aérosol (32) de manière contrôlée.
  6. Dispositif de dosage d'aérosol selon la revendication 5, dans lequel
    - le dispositif de déplacement comprend un élément d'entraînement positif et/ou par friction (42) prévu pour une liaison active avec l'élément d'entraînement positif et/ou par friction (46) du récipient de dosage d'aérosol (32).
  7. Dispositif de dosage d'aérosol selon la revendication 5 ou 6, comprenant en outre un dispositif d'alimentation en fluide (78) pour fournir du fluide dans des aérosols déchargés du récipient de dosage d'aérosol (32).
  8. Système de dosage d'aérosols comprenant :
    - un dispositif de dosage d'aérosol (2) selon l'une des revendications 6 à 8, et
    - un module d'exposition (4) avec un tube de sédimentation (14) pour alimenter un échantillon (10) en aérosol délivré par le dispositif de dosage d'aérosol (2), dans lequel
    - le tube de sédimentation (14) comporte une ouverture d'aspiration (22) pour aspirer le fluide hors du tube de sédimentation (14).
  9. Procédé pour mélanger les composants d'un aérosol dans un récipient de dosage d'aérosol, comprenant :
    - fournir un récipient de dosage d'aérosol (32) conformément à l'une des revendications 1 à 4,
    - déplacer le récipient de dosage de l'aérosol (32) et donc le ou les éléments d'agitation par rapport à l'aérosol pour mélanger ainsi ses constituants.
  10. Procédé selon la revendication 9, dans laquelle une quantité prédéterminée d'aérosol est déchargée du récipient de dosage de l'aérosol.
  11. Procédé selon la revendication 10, dans lequel l'étape consistant à distribuer une quantité prédéterminée d'aérosol à partir du récipient de dosage d'aérosol est effectuée après ou avant l'étape consistant à déplacer au moins un élément d'agitation par rapport à l'aérosol et ces étapes sont répétées au moins deux fois à des intervalles de temps prédéterminés.
  12. Procédé selon l'une quelconque des revendications 9 à 11, dans laquelle
    - une quantité prédéterminée de fluide est introduite dans l'aérosol distribué à partir du récipient de distribution de l'aérosol, et/ou
    - une quantité prédéterminée de liquide est prélevée de l'aérosol distribué par le récipient de distribution d'aérosol.
EP17001888.1A 2016-11-18 2017-11-18 Dispositifs et procédés d'exposition aux aérosols Active EP3342486B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102016013773.8A DE102016013773B4 (de) 2016-11-18 2016-11-18 Vorrichtungen und Verfahren zur Aerosolexposition

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EP3342486A2 EP3342486A2 (fr) 2018-07-04
EP3342486A3 EP3342486A3 (fr) 2018-10-03
EP3342486B1 true EP3342486B1 (fr) 2020-07-29

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DE (1) DE102016013773B4 (fr)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5829648A (en) * 1997-01-21 1998-11-03 Bath & Body Works, Inc. Sheet spray and sprayer with beads
GB2341642A (en) * 1998-07-28 2000-03-22 Robert George Shephard Aerosol container with different sized agitating elements
GB9924808D0 (en) 1999-10-21 1999-12-22 Glaxo Group Ltd Medicament dispenser
JP2005145457A (ja) 2003-10-20 2005-06-09 Mitani Valve Co Ltd エアゾール容器用バルブ機構
GB2460620B (en) 2008-03-07 2012-12-12 Otter Controls Ltd Electrical appliances and components

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
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Also Published As

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EP3342486A2 (fr) 2018-07-04
DE102016013773B4 (de) 2023-09-07
EP3342486A3 (fr) 2018-10-03
DE102016013773A1 (de) 2018-06-07

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