EP3342486A2 - Dispositifs et procédés d'exposition aux aérosols - Google Patents

Dispositifs et procédés d'exposition aux aérosols Download PDF

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Publication number
EP3342486A2
EP3342486A2 EP17001888.1A EP17001888A EP3342486A2 EP 3342486 A2 EP3342486 A2 EP 3342486A2 EP 17001888 A EP17001888 A EP 17001888A EP 3342486 A2 EP3342486 A2 EP 3342486A2
Authority
EP
European Patent Office
Prior art keywords
aerosol
dosing
container
receiving space
stirring element
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP17001888.1A
Other languages
German (de)
English (en)
Other versions
EP3342486B1 (fr
EP3342486A3 (fr
Inventor
Krebs Tobias
Heilemann Sascha
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PIETER VAN WEENEN and CO GmbH House of Innovation
Original Assignee
PIETER VAN WEENEN and CO GmbH House of Innovation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PIETER VAN WEENEN and CO GmbH House of Innovation filed Critical PIETER VAN WEENEN and CO GmbH House of Innovation
Publication of EP3342486A2 publication Critical patent/EP3342486A2/fr
Publication of EP3342486A3 publication Critical patent/EP3342486A3/fr
Application granted granted Critical
Publication of EP3342486B1 publication Critical patent/EP3342486B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
    • B65D83/38—Details of the container body
    • B65D83/388—Details of the container body with means for suspending the aerosol container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B15/00—Details of spraying plant or spraying apparatus not otherwise provided for; Accessories
    • B05B15/20—Arrangements for agitating the material to be sprayed, e.g. for stirring, mixing or homogenising
    • B05B15/25—Arrangements for agitating the material to be sprayed, e.g. for stirring, mixing or homogenising using moving elements, e.g. rotating blades
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/02—Spray pistols; Apparatus for discharge
    • B05B7/04—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge
    • B05B7/0416—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid
    • B05B7/0483—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid with gas and liquid jets intersecting in the mixing chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
    • B65D83/16—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant characterised by the actuating means
    • B65D83/26—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant characterised by the actuating means operating automatically, e.g. periodically
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
    • B65D83/38—Details of the container body
    • B65D83/384—Details of the container body comprising an aerosol container disposed in an outer shell or in an external container
    • B65D83/386—Details of the container body comprising an aerosol container disposed in an outer shell or in an external container actuation occurring by moving the aerosol container relative to the outer shell or external container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
    • B65D83/72—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant with heating or cooling devices, e.g. heat-exchangers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B13/00—Machines or plants for applying liquids or other fluent materials to surfaces of objects or other work by spraying, not covered by groups B05B1/00 - B05B11/00
    • B05B13/02—Means for supporting work; Arrangement or mounting of spray heads; Adaptation or arrangement of means for feeding work
    • B05B13/04—Means for supporting work; Arrangement or mounting of spray heads; Adaptation or arrangement of means for feeding work the spray heads being moved during spraying operation
    • B05B13/0421—Means for supporting work; Arrangement or mounting of spray heads; Adaptation or arrangement of means for feeding work the spray heads being moved during spraying operation with rotating spray heads

Definitions

  • the present invention relates to aerosol delivery devices and methods, for example in the context of biological sample assays that are to be exposed to an aerosol.
  • aerosols biological effect and activity of airborne substances, gases, mixtures, etc.
  • biological cells for example in the human or animal respiratory system
  • aerosols the biological effect and activity of airborne substances, gases, mixtures, etc.
  • This can be done by exposing a biological sample to be examined, for example, to an aerosol disposed on a membrane.
  • the stirring element can be movable in the aerosol receiving space relative to the aerosol container, wherein a movement of the stirring element can lead to a relative movement between the stirring element and the aerosol.
  • the stirring element can be connected to the aerosol container or the container closure, wherein a movement of the aerosol dosing container can lead overall to a relative movement between the stirring element and the aerosol.
  • the at least one stirring element may have at least one stirring element extending in a direction parallel and / or perpendicular to a longitudinal axis of the aerosol container.
  • the at least one stirring element may be arranged on an inner side of the aerosol container and / or on the container closure.
  • the at least one stirring element may comprise at least two stirring elements, which may be arranged on an inner side of the aerosol closure and / or may extend in a direction parallel to the longitudinal axis of the aerosol container.
  • the at least one stirring element may be formed on an insert arranged in the aerosol receiving space.
  • the at least one stirring element may comprise a magnetic stirring fish movably arranged in the aerosol receiving space.
  • the magnetic stirring fish may be formed as a stirring bar, cross stirrer, triangular stirrer or tablet stirrer or the like.
  • a positive and / or frictional drive element may be arranged to move the aerosol dosing relative to aerosol contained therein.
  • the drive member may comprise an annular and / or elongated member which may have a serrated exterior.
  • a ring-shaped element with a toothed outside can e.g. a gear or toothed ring.
  • An elongated member with a toothed outside may e.g. a rack to move the dosing in the direction of its longitudinal axis (up / down).
  • the aerosol dosing container may be an aerosol dosing container disclosed hereinabove.
  • the movement device can comprise a positive and / or frictional output element which can serve for operative connection with the positive and / or frictional drive element of the aerosol dosing container.
  • the output member may comprise an annular and / or elongate member which may have a toothed outside.
  • An annular member having a toothed outer surface may be a gear that is engageable with the gear ring or the rack of the metering container.
  • An elongate member with a serrated outer surface may be a rack which may cooperate with the gear ring or the rack of the metering container
  • the actuator may include a movable actuator that may be movable in a direction toward a bottom of an aerosol dosing container disposed in the dosing container holder.
  • the aerosol dosing assembly may include a fluid supply means which may serve to supply fluid in aerosol dispensed from the aerosol dosing container.
  • the aerosol dosing arrangement may comprise at least one heating and / or cooling device.
  • a heating and / or cooling device can be arranged in a region below the dosing container holder.
  • a heating and / or cooling device can be arranged in and / or on the dosing container holder.
  • heating and / or cooling device a device using heated and / or cooled fluid (e.g., water, air) and / or an electrically operating device may be used.
  • heated and / or cooled fluid e.g., water, air
  • the at least one stirring element may be connected to the aerosol metering container. In this case, for moving the at least one stirring element relative to the aerosol, the aerosol metering container can be moved.
  • the at least one stirring element can be movably arranged in the aerosol receiving space.
  • the at least one stirring element can be moved in the aerosol receiving space.
  • a predetermined amount of aerosol may be dispensed from the aerosol dosing tank.
  • the step of delivering a predetermined amount of aerosol from the aerosol dosing container may be performed after or prior to the step of moving at least one stirring element relative to the aerosol.
  • the steps of delivering a predetermined amount of aerosol from the aerosol dosing tank and moving the at least one agitating element relative to the aerosol may be repeated in this order or in reverse or alternating order at least twice at predetermined and / or different time intervals.
  • a predetermined amount of fluid may be supplied to the aerosol dispensed from the aerosol dosing container.
  • a predetermined amount of fluid can be removed.
  • the drawings show an aerosol metering assembly, generally designated 2, and an exposure module, generally designated 4.
  • the exposure module 4 has one or more sample receiving areas 6, in which, for example, by means of so-called inserts 8 (for example, inserts designated as Transwell®), biological samples 10 to be examined can be arranged.
  • inserts 8 for example, inserts designated as Transwell®
  • nutrient solution 12 for the samples 10 may be present.
  • the sample receiving areas 6 are each assigned a sedimentation tube 14, each defining a sedimentation channel 16 extending between a sedimentation channel outlet 18 opposite the respective sample 10 and a sedimentation channel inlet 20 located at the end opposite the sedimentation channel outlet 18 lies. Via the sedimentation tubes 14 or through the sedimentation channels 16, aerosol can be supplied to the respective samples 10.
  • the sedimentation tubes 16 may each have a suction opening 22 which provides a fluid connection to the respective sedimentation channel 16. Via the suction openings 22, gaseous constituents which for example should not pass to the samples can be removed from the respective sedimentation channel 16 flowing through and / or sinking into the aerosol.
  • the suction openings 22 may each be connected to a suction line 24, which in turn lead to a suction device 26 (eg a pump). (please refer Fig. 4a )
  • a suction tube 28 (see Fig. 4b and 4c ) are introduced into the respective sedimentation channel 16. In this way, 16 fluid can be sucked / removed, for example, at a predetermined location or area in the sedimentation channel.
  • the suction tube 28 can be guided down (just) over the surface of a sample 10.
  • a suction tube 28 may be like a cannula.
  • the aerosol dosing arrangement 2 comprises one or more dosing container holders 30, in each of which an aerosol dosing container 32 can be arranged. Preferably corresponds the number of dosing container holders 30 of the number of sample receiving areas 6.
  • a dosing container holders 30 and components of the aerosol dosing arrangement 2 used therewith will be described. The statements made with respect to a Dosier sucher holders 30 apply mutatis mutandis to each other, unless otherwise specified.
  • the dosing container holder 30 comprises a sleeve 34 in which an aerosol dosing container 32 can be accommodated.
  • a frictional operative connection between the outside of the aerosol dosing 32 and the inside of the sleeve 34 may be provided. This can be done for example by means of an O-ring 36 at the top end of the sleeve 34 as shown.
  • the dosing container holder 30 further has in each case a drive device 38 which according to the drawings comprises a sleeve 40 arranged on the outside of the sleeve 34 and a drive element 42 arranged on the outside of the sleeve 40.
  • the drive element 42 may be arranged directly on the sleeve 34.
  • the drive element 42 has an outer circumferential surface 44, which is designed for a non-positive and / or positive operative connection with a correspondingly configured output element 46, which will be described below.
  • the outer peripheral surface 44 may have a serrated surface to transmit forces and / or movements of a likewise toothed driven member 46 therefrom to the drive member 42 to move the drive member 42 (e.g., rotationally and / or translationally).
  • the drive member 42 may also be referred to as a gear.
  • the outer peripheral surface 44 may have a surface that is suitable, for example, by coating and / or due to its material, so that forces and / or movements of an output element 46 on the drive member 42 and thus the drive device 38 can be transmitted by traction to move them ( eg rotational and / or translational).
  • the drive element 42 may also be referred to as a friction wheel.
  • movements of the drive device 38 can be transmitted to the sleeve 34 and an aerosol metering container 32 arranged therein.
  • the device 50 may, as shown, comprise one or more ball bearings 50 whose outer ring is connected to the holder main body 48 and whose inner ring is connected to the sleeves 34 and / or the sleeve 40.
  • the aerosol dosing arrangement 2 further comprises a drive device 52 which has an output element 46 provided for operative connection with the drive device 38 and serves to drive the drive device 38.
  • the output element 46 has an outer peripheral surface 54, which is designed for a non-positive and / or positive operative connection with a correspondingly designed drive element 42 (see above).
  • the outer peripheral surface 42 may have a toothed surface.
  • the output member 46 may also be referred to as a gear.
  • the outer peripheral surface 54 may have an area, e.g. by coating and / or by virtue of its material, so that forces of the output element 46 can be transmitted to a drive element 42 and thus to a drive device 38 by means of adhesion in order to move it (for example rotationally and / or translationally).
  • the output member 46 may also be referred to as a friction wheel.
  • the drive device 52 comprises a controllable drive 56, for example an electric motor, which is preferably designed or can be operated as a stepper motor.
  • the output shaft 58 of the drive 56 may be connected directly or by means of a translation / transmission to the output element 46 in order to transmit rotations of the output shaft 58 1: 1 or over- or underdriven to the output element 46.
  • the drive 56 is connected via a wired and / or wireless connection V to a controller ST.
  • the connection V may also be configured to power the drive 56.
  • a separate power supply or a power supply can be provided, which is arranged in or on the aerosol dosing arrangement 2.
  • the drive devices 38 and 52 may be configured to translate an aerosol dosing container 32 in a direction substantially parallel to its longitudinal axis as depicted.
  • the drive element 42 may be e.g. be formed as extending in a direction parallel to the longitudinal axis of the sleeve 34 and an arranged therein aerosol dosing 32 extending elongated drive element.
  • an elongate rack and / or frictional engagement surface and / or coating extending along the outside of the sleeve 34 (or sleeve 40) may be used for this purpose.
  • a drive element 46 can here also a gear or friction wheel are used, which can be controlled by means of the controlled drive 56 to move an aerosol dosing 32 in the desired manner translationally (as shown up and / or down).
  • a common drive device 52 may be used, which may be e.g. a shared drive 56 and for the various dosing container holders 30 and their drive devices 38 each having an output element 46.
  • the aerosol dosing arrangement 2 has an actuating device 60, which comprises a selectively controllable, movable actuating element 62.
  • Actuator 62 may be pneumatically actuated, for example, by means of an electric or hydraulic drive or, as shown, via pneumatic ports 64 and 66.
  • the actuator 62 may be moved in the direction of the arrow 68 toward an aerosol dosing tank 32 to contact it and thereby actuate, as explained below.
  • the actuator 62 By movement of the actuating element 62 against the direction of the arrow 68, the operative connection with the aerosol dosing 32 and thus its operation can be terminated.
  • the aerosol dosing arrangement 2 may have a cover 72 which can be assigned by means of a joint / swivel mechanism 70.
  • a cover 72 which can be assigned by means of a joint / swivel mechanism 70.
  • the aerosol dosing assembly 2 may include a heating and / or cooling device 74, which may include, for example, channels 76 through which heated and / or cooled fluid (e.g., heated / cooled water, air) may be passed.
  • heated and / or cooled fluid e.g., heated / cooled water, air
  • the aerosol dosing arrangement 2 can comprise a further heating and / or cooling device, which is integrated, for example, in the dosing container holder 30 (arranged there in / on the sleeve 34), for example, around an aerosol dosing container 32 arranged there to a predetermined temperature or to bring or keep in a certain temperature range.
  • the aerosol dosing assembly 2 may include a fluid delivery device 78.
  • the fluid supply device 78 can serve to introduce fluid, in particular air or another gas, into and / or into a sinking aerosol flowing through a sedimentation channel 16.
  • the fluid delivery device 78 has one or more supply lines 80 that can be connected to a preferably controllable fluid source 82 that can supply desired fluid and includes, for example, a pump.
  • the fluid source 82 may also be used in common for a plurality of sedimentation tubes 14.
  • a fluid supply device 78 further comprises inlet channels 84 which extend from a corresponding one of the supply lines 80 to a sedimentation tube 14.
  • the sedimentation tubes 14 have openings 86 adjacent to the respective sedimentation channel inlet 20.
  • the free ends of the inlet channels 84, where fluid to be introduced into the sedimentation channels 16, can protrude into the openings 86 or are at least so slightly spaced from the openings 86 that fluid can be introduced into the openings 86 and thus into the sedimentation channels 16.
  • the outlets of the inlet channels 84 and / or the sedimentation tubes 14 may be designed such that fluid can be introduced directly into the sedimentation channel inlets 20.
  • the inlet channels 84 may be connected to the openings 86 or connected to these.
  • An aerosol dosing container 32 includes an aerosol container 88 defining an aerosol receiving space 90 and having an aerosol container opening 92.
  • the aerosol container 88 is closed in a fluid-tight manner by means of a container closure 94 attached to the aerosol container opening 92.
  • the container closure 94 comprises a metering valve 96 which, when actuated, emits or passes a predetermined amount of aerosol contained in the aerosol container 88 via a movable valve outlet 98.
  • the metering valve 96 may be configured so that it is opened by an operation and automatically closes automatically after a predetermined period of time. Alternatively, the metering valve 96 may be configured to be opened by actuation while remaining open as long as the actuation continues and closes only when the actuation is terminated.
  • a metering valve 96 is provided which can be actuated by providing for relative movement between metering valve 96 (and in particular its valve outlet 98) and aerosol container 88.
  • Aerosol in the aerosol dosing tank 32 may include particles and gas, particularly propellant. During storage and also when arranged in a dosing container holder 30, it may be in the aerosol dosing 32 to sedimentation of particles contained in the aerosol come. This results in the aerosol in the aerosol dosing tank 32 not having a homogeneous uniform composition (more).
  • one or more stirring elements 102 are provided in the aerosol container 88.
  • One or more stirring elements 102 may be disposed on the inside of the container closure 94 and extending therefrom into the aerosol receiving space 90; preferably in the longitudinal direction of the aerosol container 88 and / or at a slight angle thereto.
  • three stirring elements of the same or different lengths, even with bevelled ends, can be used. (please refer Fig. 9-12 ).
  • one or more stirring elements 102 may be provided, which extend from the inside at the bottom 100 of the dosing container 88 inwardly into the aerosol receiving space 90 in; preferably in the longitudinal direction of the aerosol container 88 and / or at a slight angle thereto.
  • three stirring elements of the same or different lengths, even with bevelled ends can be used. (please refer Fig. 13 ).
  • one or more stirring elements 102 may be provided, which, starting from an inner circumferential surface 104 of the dosing container 88, extend inwards into the aerosol receiving space 90; preferably transversely to the longitudinal direction of the aerosol container 88 and / or at a slight angle thereto.
  • three stirring elements of the same or different lengths, even with bevelled ends can be used. (please refer Fig. 14 )
  • stirring elements 102 which can move freely in the aerosol receiving space 90 (s. Fig. 15-16 ).
  • Such stirring elements 102 may be partially magnetic.
  • Non-floating stirring elements 102 may be attached to the inside of the container closure 94 and / or the inside of the bottom 100 and / or the inside surface 104 of the dosing container 88.
  • freely movable stirring elements 102 can be attached to and / or formed on an insert E, which can be introduced into the metering container 88.
  • freely movable stirring elements 102 can be provided by corresponding formations of the inner sides of the dosing container 88.
  • the function of the stirring elements 102 is to stir in the aerosol or to mix its constituents, in particular to provide for sedimentation for a homogeneous mixture / distribution of aerosol constituents.
  • the mixing by means of the stirring elements 102 can be achieved by moving them relative to the aerosol contained in the aerosol container 88.
  • Such movement of an aerosol dosing tank 32 can be accomplished by manually moving the aerosol dosing tank 32.
  • the mixing can be achieved by means of the stirring elements 102, if freely movable stirring elements 102 are present in the aerosol receiving space.
  • the free moving stirring elements 102 Upon movement of an aerosol dosing container 32 (e.g., manually or by means of the drive devices 38 and 52), the free moving stirring elements 102 will (at least initially) not move, resulting in relative movement to the aerosol in the aerosol container 88 or its components.
  • stirring elements 102 may be used, which are partly magnetic. Such more magnetic elements 102 can be moved by means of an externally applied magnetic field to stir in the aerosol or to mix its components, as with a magnetic stirrer. This can be done with aerosol metering container 32 per se, when applied to an aerosol dosing 32 corresponding magnetic field.
  • the aerosol dosing arrangement comprises 2, a magnetic field generating device that can generate a magnetic field to move magnetic stirring elements 102 in an aerosol receiving space.
  • samples 10 are arranged and the exposure module 4 is positioned below the aerosol dosing assembly as illustrated in the drawings.
  • the drive device 52 is operated in a controlled manner so that the aerosol dosing containers 32 in FIG be rotated as desired.
  • Such a mixing operation can be carried out prior to each delivery of aerosol from the aerosol dosing containers 32 by actuation of the respective dosing valve 96, even before the first time.
  • the mixing operations with respect to the various aerosol dosing containers 32 can take place simultaneously, with a time delay, overlapping, etc.
  • the respective metering valve 96 discharges a certain amount of aerosol, which reaches the respective sample via a corresponding sedimentation channel.
  • fluid for example air
  • the respective (or possibly common) fluid supply device 78 in order, for example, to dilute the aerosol.
  • fluid for example air, propellant gas
  • suction opening 22 in order, for example, to prevent unwanted effects on the respective sample 10.
  • the aerosol delivery can be done once, several times and as long until no more aerosol is available or is no longer available in such an amount that the predetermined amount of aerosol can be delivered.
  • One or more mixing operations may be performed between each or after a predetermined number of aerosol deliveries.
  • Aerosol dosing 2 exposure module 4 Sample-receiving region 6 insert 8th sample 10 broth 12 sedimentation 14 Sedimentationskanal 16 Sedimentationskanal outlet 18 Sedimentationskanal inlet 20 suction 22 suction 24 suction 26 suction tube 28 Metering container holder 30 Aerosol dispensing container 32 Sleeve for receiving an aerosol dosing 34 O-ring 36 Drive device (holder) 38 Sleeve of the drive device 40 driving element 42 Outer peripheral surface of the drive element 44 output element 46 Holder main body 48 Support / bearing device (ball bearing) 50 driving device 52 Outer peripheral surface of the output element 54 Drive of the drive device 56 Connection drive control V control ST Output shaft of the drive 58 actuator 60 actuator 62 pneumatic connection 64 pneumatic connection 66 Arrow (actuating direction of the actuating element) 68 Joint / swivel mechanism 70 cover 72

Landscapes

  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
EP17001888.1A 2016-11-18 2017-11-18 Dispositifs et procédés d'exposition aux aérosols Active EP3342486B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102016013773.8A DE102016013773B4 (de) 2016-11-18 2016-11-18 Vorrichtungen und Verfahren zur Aerosolexposition

Publications (3)

Publication Number Publication Date
EP3342486A2 true EP3342486A2 (fr) 2018-07-04
EP3342486A3 EP3342486A3 (fr) 2018-10-03
EP3342486B1 EP3342486B1 (fr) 2020-07-29

Family

ID=60413020

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17001888.1A Active EP3342486B1 (fr) 2016-11-18 2017-11-18 Dispositifs et procédés d'exposition aux aérosols

Country Status (2)

Country Link
EP (1) EP3342486B1 (fr)
DE (1) DE102016013773B4 (fr)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5829648A (en) * 1997-01-21 1998-11-03 Bath & Body Works, Inc. Sheet spray and sprayer with beads
GB2341642A (en) * 1998-07-28 2000-03-22 Robert George Shephard Aerosol container with different sized agitating elements
GB9924808D0 (en) 1999-10-21 1999-12-22 Glaxo Group Ltd Medicament dispenser
JP2005145457A (ja) 2003-10-20 2005-06-09 Mitani Valve Co Ltd エアゾール容器用バルブ機構
GB2460620B (en) 2008-03-07 2012-12-12 Otter Controls Ltd Electrical appliances and components

Also Published As

Publication number Publication date
EP3342486B1 (fr) 2020-07-29
DE102016013773A1 (de) 2018-06-07
EP3342486A3 (fr) 2018-10-03
DE102016013773B4 (de) 2023-09-07

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