EP3333157A4 - Composés vinyliques utilisés comme inhibiteurs du fgfr et du vegfr - Google Patents

Composés vinyliques utilisés comme inhibiteurs du fgfr et du vegfr Download PDF

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Publication number
EP3333157A4
EP3333157A4 EP16834592.4A EP16834592A EP3333157A4 EP 3333157 A4 EP3333157 A4 EP 3333157A4 EP 16834592 A EP16834592 A EP 16834592A EP 3333157 A4 EP3333157 A4 EP 3333157A4
Authority
EP
European Patent Office
Prior art keywords
fgfr
vinyl compounds
vegfr inhibitors
vegfr
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP16834592.4A
Other languages
German (de)
English (en)
Other versions
EP3333157B1 (fr
EP3333157A1 (fr
Inventor
Shuhui Chen
Zhengxia CHEN
Meibi DAI
Cheng Xie
Peng Li
Yang Zhang
Guibai LIANG
Qiang Wang
Jiangpeng LIAO
Fei Sun
Guoping Hu
Jian Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harbin Zhenbao Pharmaceutical Co Ltd
Original Assignee
Harbin Zhenbao Pharmaceutical Co Ltd
Medshine Discovery Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harbin Zhenbao Pharmaceutical Co Ltd, Medshine Discovery Inc filed Critical Harbin Zhenbao Pharmaceutical Co Ltd
Publication of EP3333157A1 publication Critical patent/EP3333157A1/fr
Publication of EP3333157A4 publication Critical patent/EP3333157A4/fr
Application granted granted Critical
Publication of EP3333157B1 publication Critical patent/EP3333157B1/fr
Active legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP16834592.4A 2015-08-07 2016-08-03 Composés vinyliques utilisés comme inhibiteurs du fgfr et du vegfr Active EP3333157B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201510484124 2015-08-07
CN201510908082 2015-12-09
PCT/CN2016/092989 WO2017024968A1 (fr) 2015-08-07 2016-08-03 Composés vinyliques utilisés comme inhibiteurs du fgfr et du vegfr

Publications (3)

Publication Number Publication Date
EP3333157A1 EP3333157A1 (fr) 2018-06-13
EP3333157A4 true EP3333157A4 (fr) 2018-10-17
EP3333157B1 EP3333157B1 (fr) 2020-12-23

Family

ID=57983012

Family Applications (1)

Application Number Title Priority Date Filing Date
EP16834592.4A Active EP3333157B1 (fr) 2015-08-07 2016-08-03 Composés vinyliques utilisés comme inhibiteurs du fgfr et du vegfr

Country Status (5)

Country Link
US (1) US10519133B2 (fr)
EP (1) EP3333157B1 (fr)
JP (1) JP6898306B2 (fr)
CN (1) CN107922349B (fr)
WO (1) WO2017024968A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6803410B2 (ja) * 2017-02-14 2020-12-23 富士フイルム株式会社 インダゾール化合物の製造方法およびインダゾール化合物
CN116283940A (zh) * 2017-12-07 2023-06-23 哈尔滨珍宝制药有限公司 一种作为fgfr和vegfr抑制剂化合物的盐型、晶型及其制备方法
CN113490667B (zh) * 2018-12-29 2023-10-27 盛世泰科生物医药技术(苏州)股份有限公司 作为fgfr和vegfr双重抑制剂的咪唑并吡啶衍生物
EP3919478A4 (fr) * 2019-02-02 2022-12-07 Shanghai Fosun Pharmaceutical Industrial Development Co., Ltd. Composé de vinylpyridine carboxamide utile en tant qu'immunomodulateur pd-l1
AU2020214518B2 (en) * 2019-02-02 2022-12-15 Novaonco Js Therapeutics Co., Ltd. Fluorovinylbenzamide compound as PD-L1 immunomodulator
CN113993867B (zh) * 2019-06-14 2023-10-24 盛世泰科生物医药技术(苏州)股份有限公司 作为fgfr和vegfr双重抑制剂的并环类化合物
CN114072387B (zh) * 2019-11-06 2024-03-08 暨南大学 吲唑类化合物及其药用组合物和应用
WO2021138391A1 (fr) * 2019-12-30 2021-07-08 Tyra Biosciences, Inc. Composés d'indazole
JP2023536603A (ja) * 2020-08-11 2023-08-28 ホーナン メディノ ファーマシューティカル テクノロジー カンパニー リミテッド Ｆｇｆｒ阻害剤化合物及びその使用
US20240109865A1 (en) * 2020-12-30 2024-04-04 Tyra Biosciences, Inc. Indazole compounds as kinase inhibitors
WO2023279041A1 (fr) * 2021-06-30 2023-01-05 Tyra Biosciences, Inc. Composés indazoles
WO2024006897A1 (fr) * 2022-06-29 2024-01-04 Tyra Biosciences, Inc. Composés d'indazole

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001053268A2 (fr) * 2000-01-18 2001-07-26 Agouron Pharmaceuticals, Inc. Composes d'indazole, compositions pharmaceutiques, et methodes destines a la mediation ou a l'inhibition de la proliferation cellulaire

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020010137A1 (en) * 1997-09-18 2002-01-24 Genentech, Inc. Methods and compositions for inhibiting neoplastic cell growth
US6897231B2 (en) * 2000-07-31 2005-05-24 Signal Pharmaceuticals, Inc. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
EA006711B1 (ru) 2000-09-11 2006-02-24 Чирон Корпорейшн Хинолиноновые производные в качестве ингибиторов тирозинкиназы
EP1401831A1 (fr) 2001-07-03 2004-03-31 Chiron Corporation Composes d'indazole benzimidazole utilises comme inhibiteurs de tyrosine et de serine/threonine kinase
KR20050004214A (ko) 2002-05-31 2005-01-12 에자이 가부시키가이샤 피라졸 화합물 및 이것을 포함하여 이루어지는 의약 조성물
WO2004050088A1 (fr) * 2002-12-03 2004-06-17 Kyowa Hakko Kogyo Co., Ltd. Inhibiteur de jnk
NZ540340A (en) * 2002-12-19 2007-07-27 Pfizer 2-(1H-indazol-6-ylamino)-benzamide compounds as protein kinases inhibitors useful for the treatment of ophthalmic diseases
WO2007058626A1 (fr) * 2005-11-16 2007-05-24 S*Bio Pte Ltd Composes d'indazole
CA2644910C (fr) * 2006-03-31 2014-01-28 Abbott Laboratories Composes d'indazole
JO2860B1 (en) * 2009-05-07 2015-03-15 ايلي ليلي اند كومباني Phenylendazolyl compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001053268A2 (fr) * 2000-01-18 2001-07-26 Agouron Pharmaceuticals, Inc. Composes d'indazole, compositions pharmaceutiques, et methodes destines a la mediation ou a l'inhibition de la proliferation cellulaire

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2017024968A1 *

Also Published As

Publication number Publication date
EP3333157B1 (fr) 2020-12-23
WO2017024968A1 (fr) 2017-02-16
CN107922349A (zh) 2018-04-17
EP3333157A1 (fr) 2018-06-13
US10519133B2 (en) 2019-12-31
CN107922349B (zh) 2021-05-07
US20180222886A1 (en) 2018-08-09
JP2018531218A (ja) 2018-10-25
JP6898306B2 (ja) 2021-07-07

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