EP3322484A4 - Compositions et méthodes pour le traitement du cancer - Google Patents

Compositions et méthodes pour le traitement du cancer Download PDF

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Publication number
EP3322484A4
EP3322484A4 EP16825114.8A EP16825114A EP3322484A4 EP 3322484 A4 EP3322484 A4 EP 3322484A4 EP 16825114 A EP16825114 A EP 16825114A EP 3322484 A4 EP3322484 A4 EP 3322484A4
Authority
EP
European Patent Office
Prior art keywords
compositions
methods
treating cancer
cancer
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP16825114.8A
Other languages
German (de)
English (en)
Other versions
EP3322484B1 (fr
EP3322484A1 (fr
Inventor
Lilian Emilia Van Vlerken-Ysla
Elaine Marie Hurt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MedImmune LLC
Original Assignee
MedImmune LLC
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Publication of EP3322484A1 publication Critical patent/EP3322484A1/fr
Publication of EP3322484A4 publication Critical patent/EP3322484A4/fr
Application granted granted Critical
Publication of EP3322484B1 publication Critical patent/EP3322484B1/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/715—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons
    • G01N2333/7158—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons for chemokines

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
EP16825114.8A 2015-07-14 2016-07-13 Méthode de détection de cellules souches cancéreuses Active EP3322484B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562192204P 2015-07-14 2015-07-14
PCT/US2016/042100 WO2017011559A1 (fr) 2015-07-14 2016-07-13 Compositions et méthodes pour le traitement du cancer

Publications (3)

Publication Number Publication Date
EP3322484A1 EP3322484A1 (fr) 2018-05-23
EP3322484A4 true EP3322484A4 (fr) 2019-03-06
EP3322484B1 EP3322484B1 (fr) 2021-03-24

Family

ID=57757548

Family Applications (1)

Application Number Title Priority Date Filing Date
EP16825114.8A Active EP3322484B1 (fr) 2015-07-14 2016-07-13 Méthode de détection de cellules souches cancéreuses

Country Status (13)

Country Link
US (3) US20180237515A1 (fr)
EP (1) EP3322484B1 (fr)
JP (1) JP6895946B2 (fr)
KR (1) KR20180027568A (fr)
CN (1) CN107847764B (fr)
AU (2) AU2016291803A1 (fr)
CA (1) CA2992091A1 (fr)
ES (1) ES2871252T3 (fr)
HK (1) HK1250958A1 (fr)
IL (1) IL256763A (fr)
RU (1) RU2729396C2 (fr)
SG (1) SG10201912086QA (fr)
WO (1) WO2017011559A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4278016A1 (fr) 2021-01-15 2023-11-22 Universite De Fribourg Biomarqueurs pour la détection du cancer du sein

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009156994A1 (fr) * 2008-06-24 2009-12-30 Hadasit Medical Research Services And Development Ltd. Anticorps spécifiques de ccl20 pour la thérapie du cancer

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050011741A (ko) 2002-04-11 2005-01-29 메드이뮨 백신즈 인코포레이티드 분무 건조에 의한 생물학적 활성 물질의 보존
WO2003086443A1 (fr) 2002-04-11 2003-10-23 Medimmune Vaccines, Inc. Lyophilisation par pulverisation de compositions pour administration intranasale
CA2849556A1 (fr) 2002-04-11 2003-10-23 Vu Truong-Le Conservation de matieres bio-actives au moyen de mousse lyophilisee
AU2003234090A1 (en) 2002-04-11 2003-10-27 Medimmune Vaccines, Inc. Spray freeze dry of compositions for pulmonary administration
EP1581639A4 (fr) 2002-12-17 2006-03-08 Medimmune Vaccines Inc Pulv risation haute pression de mat riaux bioactifs
US20070099209A1 (en) * 2005-06-13 2007-05-03 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
EP2069401A4 (fr) 2007-07-31 2011-02-23 Medimmune Llc Protéines de liaison à épitope multispécifiques et leurs utilisations
EP2166021A1 (fr) * 2008-09-16 2010-03-24 Ganymed Pharmaceuticals AG Anticorps monoclonaux pour le traitement du cancer
KR100950195B1 (ko) * 2009-03-20 2010-03-29 서울대학교산학협력단 Ｚｎｆ281을 발현하는 제대혈 유래 만능 줄기세포의 분리방법
JP5864564B2 (ja) * 2010-06-28 2016-02-17 ユニベルシテーツクリニクム フライブルグ 線維性疾患および癌における治療選択肢としてのｃｃｒ６を介するｃｃｌ１８シグナル伝達の遮断
EP2640744A4 (fr) * 2010-11-19 2014-05-28 Eisai R&D Man Co Ltd Neutralisation d'anticorps anti-ccl20
WO2012122015A2 (fr) * 2011-03-04 2012-09-13 Immune Disease Institute, Inc. Inhibiteurs sélectifs de cellules initiatrices de tumeur
EP2729488A4 (fr) 2011-07-06 2015-01-14 Medimmune Llc Procédé de préparation de polypeptides multimères
US9057055B2 (en) * 2012-12-05 2015-06-16 The Royal Institution For The Advancement Of Learning/Mcgill University Method of obtaining circulating cancer cell populations

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009156994A1 (fr) * 2008-06-24 2009-12-30 Hadasit Medical Research Services And Development Ltd. Anticorps spécifiques de ccl20 pour la thérapie du cancer

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DARASH-YAHANA MERAV ET AL: "Pro-tumorigenic roles for CCL20, CCR6, IL-23 and Th17 cells in human prostate cancer", AMERICAN ASSOCIATION FOR CANCER RESEARCH. PROCEEDINGS OF THE ANNUAL MEETING, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 49, 1 April 2008 (2008-04-01), pages 1281, XP009123895, ISSN: 0197-016X *
KANG-JIE CHEN ET AL: "Selective Recruitment of Regulatory T Cell through CCR6-CCL20 in Hepatocellular Carcinoma Fosters Tumor Progression and Predicts Poor Prognosis", PLOS ONE, vol. 6, no. 9, 14 September 2011 (2011-09-14), pages e24671, XP055320611, DOI: 10.1371/journal.pone.0024671 *
KLEEFF J ET AL: "DETECTION AND LOCALIZATION OF MIP-3ALPHA/LARC/EXODUS, A MACROPHAGE PROINFLAMMATORY CHEMOKINE, AND ITS CCR6 RECEPTOR IN HUMAN PANCREATIC CANCER", INTERNATIONAL JOURNAL OF CA, JOHN WILEY & SONS, INC, US, vol. 81, no. 4, 17 May 1999 (1999-05-17), pages 650 - 657, XP008054224, ISSN: 0020-7136, DOI: 10.1002/(SICI)1097-0215(19990517)81:4<650::AID-IJC23>3.0.CO;2-# *
RUBIE CLAUDIA ET AL: "CCL20/CCR6 expression profile in pancreatic cancer", JOURNAL OF TRANSLATIONAL MEDICINE, BIOMED CENTRAL, vol. 8, no. 1, 10 May 2010 (2010-05-10), pages 45, XP021078872, ISSN: 1479-5876, DOI: 10.1186/1479-5876-8-45 *
See also references of WO2017011559A1 *

Also Published As

Publication number Publication date
KR20180027568A (ko) 2018-03-14
AU2016291803A1 (en) 2018-02-22
CA2992091A1 (fr) 2017-01-19
RU2729396C2 (ru) 2020-08-06
HK1250958A1 (zh) 2019-01-18
WO2017011559A8 (fr) 2018-02-01
ES2871252T3 (es) 2021-10-28
RU2018105217A (ru) 2019-08-14
EP3322484B1 (fr) 2021-03-24
US20200102382A1 (en) 2020-04-02
JP2018520177A (ja) 2018-07-26
RU2018105217A3 (fr) 2020-01-27
US20210380673A1 (en) 2021-12-09
CN107847764B (zh) 2022-07-05
IL256763A (en) 2018-03-29
US20180237515A1 (en) 2018-08-23
AU2019229394A1 (en) 2019-10-03
JP6895946B2 (ja) 2021-06-30
WO2017011559A1 (fr) 2017-01-19
EP3322484A1 (fr) 2018-05-23
SG10201912086QA (en) 2020-02-27
CN107847764A (zh) 2018-03-27

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