EP3302351B1 - Trinkhalm zum einhalten einer vorbestimmten dosis einer flüssigkeitsbasierten substanz sowie injektionsvorrichtung und verfahren damit - Google Patents

Trinkhalm zum einhalten einer vorbestimmten dosis einer flüssigkeitsbasierten substanz sowie injektionsvorrichtung und verfahren damit Download PDF

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Publication number
EP3302351B1
EP3302351B1 EP16738477.5A EP16738477A EP3302351B1 EP 3302351 B1 EP3302351 B1 EP 3302351B1 EP 16738477 A EP16738477 A EP 16738477A EP 3302351 B1 EP3302351 B1 EP 3302351B1
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EP
European Patent Office
Prior art keywords
tube
stopper
straw
tip
towards
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Application number
EP16738477.5A
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English (en)
French (fr)
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EP3302351A1 (de
Inventor
Anne Linda VAN KAPPEL-DUFOUR
Jean-Charles GORGES
Eric Schmitt
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IMV Technologies SA
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IMV Technologies SA
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Publication of EP3302351A1 publication Critical patent/EP3302351A1/de
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00—Instruments or methods for reproduction or fertilisation
    • A61D19/02—Instruments or methods for reproduction or fertilisation for artificial insemination
    • A61D19/022—Containers for animal semen, e.g. pouches or vials ; Methods or apparatus for treating or handling animal semen containers, e.g. filling or closing
    • A61D19/024—Tube-like containers, e.g. straws
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00—Instruments or methods for reproduction or fertilisation
    • A61D19/02—Instruments or methods for reproduction or fertilisation for artificial insemination
    • A61D19/027—Devices for injecting semen into animals, e.g. syringes, guns, probes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components

Definitions

  • the invention relates generally to the preservation of a predetermined dose of liquid-based substance, and more particularly to flakes for effecting such preservation.
  • Such straw comprises a tube and a plug disposed in the tube.
  • the plug is usually of the tripartite type originally described in the French patent 995878 , corresponding to the British patent 669.265 that is to say formed by two buffers of fibrous substance enclosing a powder transforming in contact with a liquid into a paste or impermeable gel adhering to the wall of the tube so that the cap is liquid-tight.
  • plugs of another type for example a plug comprising or associated with an insert described by the French patent application. 2,771,284 corresponding to the US patent 6300125 , by the French patent application 2,771,285 corresponding to the US patent application 2001/0014376 , by the French patent application 2,784,572 corresponding to the US patent 6416611 and by the French patent application 2,932,064 ; or a plug made of a monobloc cylinder of hydrophobic microporous material described by the European patent application 0 873 726 ; or finally a plug made of a monoblock cylinder of self-sealing sintered microporous material described by the application PCT WO 2010/070533 .
  • the US patent 6305585 discloses a straw according to the preamble of claim 1.
  • the stopper In the initial state, the stopper is disposed in the vicinity of one of the ends of the tube and it is expected that in the filled state, the dose of liquid substance that must be stored in the straw is disposed between the stopper and the other end of the tube (end farthest from the plug).
  • the end closest to the plug is placed in communication with a source of vacuum while the end farthest from the plug is placed in communication with a container containing the substance to be introduced into the straw.
  • the air initially contained between the plug and the end of the tube furthest from the plug is sucked through the plug as the substance progresses in the tube until it meets the plug.
  • the straw is welded in the vicinity of one or both ends and is stored cold.
  • the straw and in particular the material of the tube are provided so that cold storage can be performed by immersing the straw in a liquid cryogenic agent such as liquid nitrogen.
  • the invention aims to provide such a straw that offers operators new capabilities while remaining simple, convenient and economical to manufacture and use.
  • the inner conduit of the syringe needle can thus be placed in communication, via the internal conduit of the stopper, with the space inside the tube located between the second end of the stopper and the second end of the tube.
  • This internal space in the tube is intended, as in conventional flakes, to receive the predetermined dose of liquid-based substance.
  • a syringe needle for example an injection needle
  • the dose of substance contained in the straw is drawn towards the stopper, for example as explained below. afterwards, the substance will pass through the internal duct of the stopper and then the internal duct of the needle and may be expelled at the distal end of the needle, that is to say the pointed end located on the opposite side to the needle. the female end of the needle.
  • the stopper is not moved to push the dose of substance towards the second end of the tube but that the stopper is fixed and that it is the dose of substance that is pushed towards the stopper and therefore towards the first end of the tube.
  • the straw according to the invention can thus play not only the role of a substance conditioning element of the substance for its preservation, including cryogenic temperatures (traditional role for a straw), but also the role of a body of syringe to which a syringe needle can be directly connected and whose contents can be ejected through the distal end of this needle.
  • the straw according to the invention makes it possible to prevent the dose of substance must be transferred from the conditioning unit that it constitutes to a syringe body.
  • the handling of the liquid-based substance is diminished, which is in some cases favorable to the preservation of its properties, in particular if the substance contains constituents sensitive to the mechanical stresses occurring during the passage in a narrow conduit such as the inner duct of an injection needle.
  • a substance is for example a vaccine comprising cells sensitive to mechanical stresses.
  • the flake according to the invention makes it possible to benefit from the conditioning qualities of the liquid-based substances offered by the flakes, from the compatibility with the existing cold-keeping devices of the flakes, including at cryogenic temperatures, for example the conventional cups for maintaining the flakes.
  • glitter in liquid nitrogen while providing the capabilities of a syringe body; and this simply by implementing in a thin tube of flake a cap configured accordingly.
  • the first end of the plug in an initial state before use, is located in the tube at a predetermined distance from the first end of the tube for welding the tube between the first end of the plug and the first end of the tube.
  • the tip and more generally the plug is isolated from the liquid cryogen by the tube of the straw and thus protected from any cross-contamination likely to be conveyed by the liquid cryogen.
  • the straw according to the invention would have a larger capacity but could not offer such an insulation capacity of the nozzle .
  • the plug in an initial state before use, has at its first end a cap to be removed closing said internal conduit of the cap.
  • This seal is of course to be removed before emptying the straw.
  • annular wall is disposed between the cap and the male end, the inner conduit of the cap extending beyond the first end of the male end in the annular wall to the operculum which the closure, the outer surface of the annular wall being recessed vis-à-vis the outer surface of the male end.
  • the lid is removed by cutting or even tearing the annular wall.
  • the remaining annular wall piece does not interfere with the engagement of the socket as the outer surface of the annular wall is recessed from the outer surface of the socket.
  • the cap comprises a body attached to the tube and an appendage protruding from said body attached to the tube only through the body, which appendix comprises said male end and extends to the first end of the plug.
  • the plug can be effectively secured to the tube by the body while the tube leaves free the outer surface of the tip.
  • the tube can be removed around the appendix after being cut.
  • the cap body and the tube are secured independently of a plug contact with said liquid-based substance.
  • the degree of securing between the tube and the plug is the same without prior contact and after contact of the plug with the liquid-based substance.
  • the invention also aims, in a second aspect, a device for injecting a liquid-based substance comprising a straw as explained above and a syringe needle having a female connection endpiece with frustoconical inner surface engaged on the male connection end cap of said straw.
  • the invention also aims, in a third aspect, a method of emptying a straw as explained above, comprising a dose of liquid-based substance disposed between the second end of the plug and the second end of the tube, comprising the step of pushing the dose of liquid-based substance towards the first end of the tube after connecting the tip of a syringe needle to the male end of the plug.
  • the straw 10 illustrated on the figure 1 in the initial state (before use) comprises a tube 11 and a plug 12.
  • the tube 11 is extruded plastic with an internal diameter which is calibrated.
  • this internal diameter is of the order of 8.20 mm and the length of the tube 11 is of the order of 130 mm.
  • the tube 11 extends between one end 16 (which is seen on the left on the figure 1 ) and one end 17 (which is seen to the right on the figure 1 ).
  • the material of the tube 11 is here Surlyn®, which has good weldability properties and excellent compatibility with cryogenic temperatures.
  • Surlyn® which has good weldability properties and excellent compatibility with cryogenic temperatures.
  • the tube material is in another heat-shrinkable plastic material and resistant to cryogenic temperatures, for example PVC, TPE or PP.
  • the plug 12 is made of a material which has the same properties of impermeability to gases and liquids without and with prior contact of the plug with a liquid, especially aqueous.
  • the stopper 12 does not include a powdered dry sealant that turns into a paste or gel once moistened.
  • the material of the plug 12 is here polyethylene, more specifically HDPE.
  • the plug 12 is in another relatively rigid thermoplastic material, for example polypropylene (PP).
  • the plug 12 is disposed in the tube 11 near its end 16.
  • the plug 12 extends between an end 19 facing the end 16 of the tube 11 and an end 18 facing the end 17 of the tube 11.
  • the end 19 of the plug 12 is located in the tube 11 at a distance from the end 16 of the tube 11.
  • This distance has been predetermined so that it is sufficiently large for it to be possible to weld the tube 11 in the vicinity of the end 16, as shown in FIG. figure 6 .
  • the plug 12 has an axisymmetric configuration and is arranged coaxially with the tube 11.
  • the plug 12 comprises a body 9 and an appendix 63 projecting from the body 9 and extending to the end 19.
  • Appendix 63 comprises a male endpiece 29, a cap 33 located at the end 19 and an annular wall 64 connecting the cap 33 and the male endpiece 29.
  • the body 9 is directly attached to the tube 11.
  • the projection 63 protruding from the body 9 is secured to the tube 11 only via the body 9.
  • the tube 11 leaves free the external surface of the appendix 63, in particular the external surface 14 of the male endpiece 29.
  • the outer surface 14 is frustoconical normalized to cooperate with the normalized frustoconical inner surface 46 of the socket 45 of a syringe needle 44 (FIG. figure 4 ).
  • the portion of the tube 11 surrounding the appendix 63 can be cut and removed, as shown in FIG. figure 13 .
  • the dose of liquid substance 21 which must be stored in the straw 10 is disposed between the plug 12 and the end 17 of the tube 11 furthest from the plug 12.
  • the straw 10 here has a useful capacity of about 4 ml.
  • the tube 11 of the straw is welded in the vicinity of one or both of its ends 16 and 17 ( figure 6 ) and is stored cold.
  • the tube 11 has been welded at one end and the welded portion has subsequently been cut and removed, the tube 11 then has a new end set back from the initial end. Similarly, if the tube 11 has been cut to remove an end portion initially located around the appendix 63, the tube 11 then has a new end recessed from the initial end.
  • the reference numerals 16 and 17 for the new ends of the tube 11 each recessed relative to the respective initial end.
  • the plug 12 is placed in the tube 11 by simple insertion through the first end 16 of the tube 11 and forced sliding to the second end 17 of the tube 11 until reaching the intended location for the plug 12 in the tube 11.
  • the fact that the plug 12 can slide in the tube 11 only if a large force is exerted can provide a hold in place of the plug 12 in the tube 11 sufficient to take the forces exerted during connection of a syringe needle 44 ( figure 4 ) by engagement of the female connection tip 45 of the needle 44 on the male connector 29 of the plug 12 with the surface internal frustoconical 46 of the female end 45 in contact with the outer frustoconical surface 14 of the male end 29.
  • the plug 12 is configured to resist sliding towards the first end 16 of the tube 11. This allows the plug 12 to take up the major forces exerted on the end 18 of the plug 12 by the substance 21 when dump ( figures 9 and 11 ) and, where appropriate, during the freezing, where an increase in volume of the substance 21 which urges the cap 12 towards the end 16 of the tube 11 occurs.
  • the male end 29 extends between an end 60 facing the end 16 of the tube 11 and an end 61 facing the end 17 of the tube 11.
  • the frustoconical external surface 14 of the spigot 29 increases in diameter from the end 60 of the spigot 29 towards the end 61 of the spigot 29.
  • the conicity of the outer surface 14 of the male end 29 is Luer dimensions, defined by the ISO 594-1: 1986 or by DIN and EN 1707: 1996 and 20594-1: 1993.
  • An internal conduit 20 is formed in the plug 12.
  • the inner conduit 20 extends between the end 60 of the male endpiece 29 and the end 18 of the plug 12.
  • the inner conduit 20 thus passes through the male endpiece 29 and the body 9 opening into the internal space of the tube 11 intended to be filled by the substance 21.
  • the inner conduit 20 extends beyond the end 60 of the spigot 29 in the annular wall 64 to the seal 33 which closes it.
  • the cover 33 is here formed by a straight wall oriented transversely to the inner conduit 20.
  • the cover 33 is to be removed before connecting the needle 44 and empty the straw.
  • the inner conduit 20 decreases in diameter from the end 18 of the plug 12 to the end 60 of the spigot 29, with three successive frustoconical portions stepped.
  • the outer surface of the annular wall 64 is recessed vis-à-vis the outer surface 14 of the spigot 29.
  • the lid 33 is removed by cutting or even tearing the annular wall 64.
  • the remaining annular wall piece 64 does not interfere with the engagement of the socket 45 since the outer surface of the annular wall 64 is set back from the outer surface 14 of the spigot 29 (see FIG. figure 4 ).
  • the thickness of the annular wall 64 is smaller than that of the spigot 29, which facilitates the cutting of the annular wall 64 to remove the lid 33.
  • the body 9 extends between an end protruding from the appendix 63 (end facing the end 16 of the tube 11) and the end 18 of the plug 12.
  • the body 9 comprises a plurality of annular ribs 22, here two identical ribs, formed on its outer surface 28.
  • the ribs 22 are arranged at a distance from each other, with a predetermined distance between them. This gap makes it possible to stabilize the plug 12 in the tube 11.
  • Each annular rib 22 has a straight surface 24 facing the end 16 of the tube 11 and an inclined surface 25 facing the end 17 of the tube 11.
  • the surface 25 is inclined inwards and towards the end 17 of the tube 11.
  • the material in which the plug 12 is made is relatively rigid and therefore the periphery of the body 9 is relatively rigid, and in any case more than the wall of the tube 11 which is relatively thin.
  • the inclined surfaces 25 form ramps for deforming the wall of the tube 11 to allow the forced sliding of the plug 12 towards the end 17 of the tube 11.
  • the straight surfaces 24 form stops to allow the plug 12 to resist sliding relative to the tube 11.
  • the body 9 also has, at the end 18 of the plug 12, a chamfered edge forming a guide surface 23 inclined towards the inside and towards the end 18 of the plug 12.
  • the annular groove 30 is formed on the outer surface 28 near the appendix 63.
  • annular groove 30 is formed between the appendix 63 and the annular rib 22 closest.
  • the annular groove 30 has a concave curved bottom surface.
  • the annular groove 30 is useful for guiding the cutting of the tube 11, for example with the pair of curved blade scissors 53 illustrated on FIG. figure 12 .
  • the female end piece 45 extends between one end 55 that is seen to the left on the figure 4 and an end 56 that is seen on the right.
  • the female end 45 has a flange 48 at its end 56.
  • the needle 44 further comprises a hollow rod 39 projecting from the female end 45 from its first end 55.
  • the inner channel 40 of the needle 44 extends from the end 56 of the socket 45 to the tip of the hollow rod 39.
  • the hollow rod 39 here has a diameter known as gauge 18 or gauge 20.
  • the needle 44 is of the hypodermic type.
  • the frustoconical inner surface 46 of the female endpiece 45 is in contact and matches the frustoconical outer surface 14 of the male endpiece 29.
  • the inner conduit 20 of the male end 29 opens into the internal channel 40 of the needle 44.
  • the straw 10 to which is connected the needle 44 with its female connection end 45 with frustoconical inner surface 46 engaged on the male connection end 29 of the plug 12 forms a device for injecting a fluid substance whose operation is explained later.
  • the straw 10 illustrated on the figure 5 comprises a predetermined dose of liquid-based substance 21, here a concentrated vaccine solution.
  • the filling of the straw 10 is carried out using a needle (not shown), connected to a tank (not shown) of substance 21, which is inserted into the tube 11 by the end 17 of the tube 11 until its end comes near the plug 12.
  • the needle is gradually retracted.
  • the inner conduit 20 After filling, the inner conduit 20 therefore contains a certain volume of air.
  • the volume of the predetermined dose injected is such that there remains a portion of the tube 11 not filled with the substance 21 on the side of the end 17.
  • the tube 11 is then welded in the vicinity of its two ends 16 and 17.
  • a weld 41 is made using two heating jaws (not shown) between which is crushed by pinching an end portion of the tube 11.
  • the portion thus crushed takes a flattened position forming two lips 42 ( figure 9 ) brought into contact with each other.
  • the heat transmitted by the heating jaws to the material of the tube 11 causes the formation of the hermetic seal 41 between the two lips 42.
  • the flake 10 with the tube 11 welded near its two ends 16 and 17 is illustrated on the figure 6 .
  • This air bubble 43 is useful during the freezing of the straw to allow the volume increase of the substance 21.
  • the annular wall 64 of the appendix 63 is then cut and the cover 33 removed.
  • the needle 44 having the female end piece 45 is then connected to the straw.
  • the hollow stem 39 of the needle 44 is then, for example, sunk into the septum of a container containing a diluting liquid (e.g., water for injection) for concentrated vaccine solution (not shown).
  • a diluting liquid e.g., water for injection
  • a dump device (partially illustrated) is used, comprising two rollers 47 each oriented in the same direction and arranged next to each other.
  • the emptying device is configured so that the rollers 47 gradually crush the tube 11 from its end 17 to the plug 12.
  • the air bubble 43 is thus pushed in the same direction and in turn pushes the substance 21 which is introduced successively in the inner conduit 20 of the plug 12 and in the channel 40 of the needle 44 to be expelled out of the needle 44, into the container containing the dilution liquid.
  • the volume of the air bubble 43 is sufficient to fill the inner conduit 20 and the channel 40 at the moment when the rollers 47 are close to the plug 12. Thus, there is no or very little substance 21 lost in the conduit 20 and in the channel 40.
  • the emptying device comprising the rollers 47 is for example implemented by further providing a body and a rail mounted fixed on the body.
  • the rollers 47 are slidably mounted along the rail, with the rollers 47 each oriented transversely to the direction of extension of the rail.
  • the emptying device is configured to move the rollers 47 closer or closer to one another depending on where the two rollers 47 are on the rail.
  • the emptying device further comprises a resilient erasable floor disposed under the rail.
  • rollers 47 are initially positioned at a first end of the rail, access to the floor being thus cleared to allow the straw 10 to be disposed therein.
  • the straw is then disposed on the floor, being oriented in the same direction as the rail and located substantially between the paths respective of the two rollers 47, with the weld 41 of the straw facing the rollers 47.
  • the needle 44 located at the other end of the straw is engaged in a conical housing formed in the body of the device, with the outer surface of the female end abutting against the inner surface of the conical housing.
  • rollers 47 are then moved in the direction of the straw 10 and are positioned on either side of the weld 41 located near the end 17 of the straw.
  • the rollers are then spaced from each other, separated by a distance slightly greater than the thickness of the weld 41 located between them.
  • the rollers 47 continue their course by approaching each other until the tube 11 of the straw 10 is crushed. The distance between the rollers is then approximately equal to twice the thickness of the tube wall 11.
  • rollers 47 then gradually crush the tube 11 as explained above.
  • roller 47 closest to the floor (hereinafter lower roll) is pressed against an inclined surface of the floor, which solicits the floor to its erased position.
  • the straw 10 is then no longer held by the floor but remains in the same position because it is held by the rollers 47.
  • the distal end of the floor is then positioned behind the lower roller 47 and acts as a non-return stop for the two rollers 47.
  • connection of the needle 44 to the straw 10 is carried out as explained above.
  • the weld 41 located near the end 17 is removed by cutting an end portion flush with the weld 41.
  • a device (partially illustrated) having a piston 52 is employed here.
  • the piston 52 is moved to push the air bubble 43 which then pushes the substance 21 to its expulsion out of the needle 44, in the same manner as in the embodiment illustrated in FIGS. Figures 8 and 9 .
  • the flake 10 is in the state shown in FIG. figure 13 .
  • the internal diameter of the tube 111 is here of the order of 6 mm and the length of the tube 111 is of the order of 130 mm.
  • the straw 110 here has a useful capacity of about 2 ml.
  • the male end 129 is identical to the male end 29.
  • the body 109 of the plug 112 is identical to the body 9 of the plug 12, except that it is smaller in size to be able to cooperate with the tube 111, the dimensions of which are smaller than those of the tube 11.
  • the inner conduit 120 of the plug 112 is here entirely frustoconical.
  • the use of the straw 110 is identical to the use of the straw 10, except that, as the tube 111 is very close to the nozzle 129, the tube 111 is cut at the groove 130 to prevent that the tube 111 hinders the engagement of the tip 145 on the tip 129 ( figure 17 ).
  • the plug 212 shown on the figure 18 is generally similar to plug 112, except that body 209 has a single annular rib 222 and that single annular rib 222 has a different profile than ribs 122 or 22.
  • the outermost portion of the ribs 22 or 122 is formed by a stop 65 or 165
  • the outermost portion of the rib 222 is formed by a circular section surface of constant diameter 66.
  • the diameter of the surface 66 corresponds to that of the inner surface of the tube of the straw.
  • the rib 222 On either side of the surface 66, the rib 222 has an inclined surface, respectively 67 and 68.
  • the surface 67 is turned towards the first end 219 of the cap 212 and is inclined towards the first end 219 and inwards.
  • the inclined surface 68 is facing the second end 218 and is inclined towards the first end 218 and inwardly.
  • the plug 312 illustrated on the figure 19 is generally similar to the plug 112, except that the two annular ribs 122 are replaced by a single rib 322 having a large axial extension.
  • the body of the straw cap has different non-return protrusions ribs 22, 122 or 322, but arranged differently from a rib, for example in the form of a plurality of tabs.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Husbandry (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Radiation-Therapy Devices (AREA)

Claims (17)

  1. Röhrchen zum Aufbewahren einer vorbestimmten Dosis einer flüssigkeitsbasierten Substanz, enthaltend ein Rohrstück (11, 111), das sich zwischen einem ersten Ende (16, 116) und einem zweiten Ende (17, 117) erstreckt und einen flüssigkeitsdichten Stopfen (12, 112, 212, 312) enthält, der in dem Rohrstück (11, 111) benachbart zu seinem ersten Ende (16, 116) angeordnet ist und sich zwischen einem dem ersten Ende (16, 116) des Rohrstücks (11, 111) zugewandten ersten Ende (19, 119, 219, 319) und einem dem zweiten Ende (17, 117) des Rohrstücks (11, 111) zugewandten zweiten Ende (18, 118, 218, 318) erstreckt,
    dadurch gekennzeichnet, dass der Stopfen (12, 112, 212, 312)
    - bezüglich des Rohrstücks (11, 111) fest ist;
    - ein Anschlusseinsteckteil (29, 129) aufweist, das sich zwischen einem dem ersten Ende (16, 116) des Rohrstücks (11, 111) zugewandten ersten Ende (60, 160) und einem dem zweiten Ende (17, 117) des Rohrstücks (11, 111) zugewandten zweiten Ende (61, 161) erstreckt, eine standardisierte, kegelstumpfförmige Außenfläche (14, 114) aufweist, die im Durchmesser vom ersten Ende (60, 160) des Anschlussteils (29, 129) zum zweiten Ende (61, 161) des Anschlussteils (29, 129) hin zunimmt, und das dazu ausgelegt ist, dass eine Spritzennadel (44, 144) mit einem Anschlussbuchsenteil (45, 145) mit standardisierter, kegelstumpfförmiger Innenfläche (46) durch Aufschieben des Anschlussbuchsenteils (45, 145) der Nadel auf das Anschlusseinsteckteil (29, 129) des Stopfens (12, 112, 212, 312) an den Stopfen (12, 112, 212, 312) angeschlossen werden kann, wobei die kegelstumpfförmige Innenfläche (46) des Buchsenteils (45, 145) mit der kegelstumpfförmigen Außenfläche (14, 114) des Einsteckteils (29, 129) in Kontakt steht; und
    - eine innere Leitung (20, 120) aufweist, die sich zwischen dem ersten Ende (60, 160) des Anschlussteils (29, 129) und dem zweiten Ende (18, 118, 218, 318) des Stopfens (12, 112, 212, 312) erstreckt.
  2. Röhrchen nach Anspruch 1, dadurch gekennzeichnet, dass in einem ursprünglichen Zustand vor Ingebrauchnahme sich das erste Ende (19, 119, 219, 319) des Stopfens (12, 112, 212, 312) in dem Rohrstück (11, 111) in einem vorbestimmten Abstand von dem ersten Ende (16, 116) des Rohrstücks (11, 111) befindet, wodurch es möglich ist, das Rohrstück (11, 111) zwischen dem ersten Ende (19, 119, 219, 319) des Stopfens (12, 112, 212, 312) und dem ersten Ende (16, 116) des Rohrstücks (11, 111) zu verschweißen.
  3. Röhrchen nach einem der Ansprüche 1 oder 2, dadurch gekennzeichnet, dass in einem ursprünglichen Zustand vor Ingebrauchnahme der Stopfen (12, 112, 212, 312) an seinem ersten Ende (19, 119, 219, 319) einen Abziehverschluss (33, 133) enthält, welcher die innere Leitung (20) des Stopfens (12, 112, 212, 312) verschließt.
  4. Röhrchen nach Anspruch 3, dadurch gekennzeichnet, dass eine ringförmige Wand (64, 164) zwischen dem Verschluss (33, 133) und dem Einsteckteil (29, 129) angeordnet ist, wobei die innere Leitung (20, 120) des Stopfens (12, 112, 212, 312) sich über das erste Ende (60, 160) des Einsteckteils (29, 129) hinaus in der ringförmigen Wand (64, 164) bis zum die Leitung verschließenden Verschluss (33, 133) erstreckt, wobei die Außenfläche der ringförmigen Wand (64, 164) gegenüber der Außenfläche (14, 114) des Einsteckteils (29, 129) rückspringend verläuft.
  5. Röhrchen nach einem der Ansprüche 1 bis 4, dadurch gekennzeichnet, dass der Stopfen (12, 112, 212, 312) einen mit dem Rohrstück (11, 111) verbundenen Mantel (9, 109, 209, 309) und einen Fortsatz (63, 163, 263, 363) aufweist, der von dem Mantel (9, 109, 209, 309) vorspringt und nur vermittels des Mantels (9, 109, 209, 309) mit dem Rohrstück (11, 111) verbundenen ist, welcher Fortsatz (63, 163, 263, 363) das Einsteckteil (29, 129) aufweist und sich zum ersten Ende (19, 119, 219, 319) des Stopfens (12, 112, 212, 312) erstreckt.
  6. Röhrchen nach Anspruch 5, dadurch gekennzeichnet, dass der Mantel (9, 109, 209, 309) des Stopfens (12, 112, 212, 312) und das Rohrstück (11, 111) verbunden sind, ungeachtet eines Kontakts des Stopfens (12, 112, 212, 312) mit der flüssigkeitsbasierten Substanz (21).
  7. Röhrchen nach einem der Ansprüche 5 oder 6, dadurch gekennzeichnet, dass der Mantel (9, 109, 209, 309) zumindest am Umfang starr ausgeführt ist und eine Außenfläche (28, 128) aufweist, die Sperrvorsprünge (22, 122, 322) enthält, die so ausgerichtet sind, dass sie die Zwangsverschiebung des Stopfens (12, 112, 312) bezüglich des Rohrstücks (11, 111) von dem ersten Ende (16, 116) zum zweiten Ende (17, 117) gestatten und der Verschiebung des Stopfens (12, 112, 312) bezüglich des Rohrstücks (11, 111) zum ersten Ende (16, 116) des Rohrstücks (11, 111) hin entgegenstehen.
  8. Röhrchen nach einem der Ansprüche 5 bis 7, dadurch gekennzeichnet, dass der Mantel (9, 109, 209, 309) zumindest am Umfang starr ausgeführt ist und eine Außenfläche (28, 128) aufweist, die zumindest eine ringförmige Rippe (22, 122, 322) mit einer dem ersten Ende (16, 116) des Rohrstücks (11, 111) zugewandten geraden Fläche (24, 124) und einer dem zweiten Ende (17, 117) des Rohrstücks (11, 111) zugewandten geneigten Fläche (25, 125) enthält, wobei die geneigte Fläche (25, 125) zum Inneren und zum zweiten Ende (17, 117) des Rohrstücks (11, 111) hin geneigt verläuft.
  9. Röhrchen nach einem der Ansprüche 5 bis 8, dadurch gekennzeichnet, dass der Mantel (9, 109) zumindest am Umfang starr ausgeführt ist und eine Außenfläche (28, 128) aufweist, die zumindest zwei ringförmige Rippen (22, 122) enthält, die voneinander beabstandet verlaufen.
  10. Röhrchen nach einem der Ansprüche 5 bis 9, dadurch gekennzeichnet, dass der Mantel (9, 109, 209, 309) an seiner Außenfläche (28, 128) in der Nähe des Fortsatzes (63, 163, 263, 363) eine ringförmige Nut (30, 130, 230, 330) aufweist.
  11. Röhrchen nach einem der Ansprüche 1 bis 10, dadurch gekennzeichnet, dass das Anschlusseinsteckteil (29, 129) ein Luer-Einsteckteil ist.
  12. Röhrchen nach einem der Ansprüche 1 bis 11, dadurch gekennzeichnet, dass der Stopfen (12, 112, 212, 312) vollständig aus gas- und flüssigkeitsdichtem Material besteht, ungeachtet eines Kontakts des Stopfens (12, 112, 212, 312) mit der flüssigkeitsbasierten Substanz (21).
  13. Röhrchen nach einem der Ansprüche 1 bis 12, dadurch gekennzeichnet, dass der Stopfen (12, 112, 212, 312) vollständig aus einstückig geformtem, starrem Kunststoffmaterial besteht.
  14. Vorrichtung zum Injizieren einer flüssigkeitsbasierten Substanz, enthaltend ein Röhrchen (10, 110) nach einem der vorangehenden Ansprüche und eine Spritzennadel (44, 144) mit einem Anschlussbuchsenteil (45, 145) mit kegelstumpfförmiger Innenfläche (46), das auf das Anschlusseinsteckteil (29, 129) des Stopfens (12, 112, 212, 312) des Röhrchens (10, 110) aufgeschoben ist.
  15. Verfahren zum Entleeren eines Röhrchens nach einem der Ansprüche 1 bis 13, enthaltend eine Dosis einer flüssigkeitsbasierten Substanz (21), die zwischen dem zweiten Ende (18, 118, 218, 318) des Stopfens (12, 112, 212, 312) und dem zweiten Ende (17, 117) des Rohrstücks (11, 111) angeordnet ist, umfassend den Schritt des Verschiebens der Dosis der flüssigkeitsbasierten Substanz (21) zum ersten Ende (16, 116) des Rohrstücks (11, 111) hin, nachdem das Buchsenteil (45, 145) einer Spritzennadel (44, 144) an das Einsteckteil (29, 129) des Stopfens (12, 112, 212, 312) angeschlossen wurde.
  16. Verfahren nach Anspruch 15, dadurch gekennzeichnet, dass der Schritt des Verschiebens der Dosis einer flüssigkeitsbasierten Substanz (21) mit dem zweiten Ende (17, 117) des Rohrstücks (11, 111) erfolgt, das verschlossen bleibt, während das Rohrstück (11, 111) fortschreitend vom zweiten Ende (17, 117) des Rohrstücks (11, 111) zum Stopfen (12, 112, 212, 312) hin zusammengedrückt wird.
  17. Verfahren nach Anspruch 15, dadurch gekennzeichnet, dass der Schritt des Verschiebens der Dosis einer flüssigkeitsbasierten Substanz (21) mit dem offenen zweiten Ende (17, 117) des Rohrstücks (11, 111) aufgrund eines über dieses Ende (17, 117) eingeführten Kolbens (52) erfolgt, der zum Stopfen (12, 112, 212, 312) hin verlagert wird.
EP16738477.5A 2015-06-03 2016-06-02 Trinkhalm zum einhalten einer vorbestimmten dosis einer flüssigkeitsbasierten substanz sowie injektionsvorrichtung und verfahren damit Active EP3302351B1 (de)

Applications Claiming Priority (2)

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FR1555026A FR3036954B1 (fr) 2015-06-03 2015-06-03 Paillette pour la conservation d'une dose predeterminee de substance a base liquide, ainsi que dispositif d'injection et procede la mettant en oeuvre
PCT/FR2016/051321 WO2016193630A1 (fr) 2015-06-03 2016-06-02 Paillette pour la conservation d'une dose prédéterminée de substance à base liquide, ainsi que dispositif d'injection et procédé la mettant en oeuvre

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EP3302351A1 EP3302351A1 (de) 2018-04-11
EP3302351B1 true EP3302351B1 (de) 2019-03-20

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EP (1) EP3302351B1 (de)
CN (1) CN107708608B (de)
BR (1) BR112017025219A2 (de)
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WO (1) WO2016193630A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3074419B1 (fr) 2017-12-05 2019-12-27 Imv Technologies Paillette pour la conservation cryogenique d'une dose de substance a base liquide, ensemble la comportant et procede de vidage de cette paillette
FR3075056A1 (fr) * 2017-12-14 2019-06-21 Etablissement Francais Du Sang Dispositif d'injection cryoresistant pret a l'emploi
US11116206B2 (en) 2018-10-01 2021-09-14 Cook Medical Technologies Llc Cryocontainer

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2717601A (en) * 1949-08-10 1955-09-13 Frederick M Turnbull Syringe ampule
BE498210A (de) 1949-09-20
US3805784A (en) * 1972-08-04 1974-04-23 R Alter Semen capsule for use with an artificial insemination applicator
US4022206A (en) 1975-08-01 1977-05-10 Merck & Co., Inc. Vaccine delivery system
GB2090743B (en) * 1981-01-08 1985-12-04 Cassou Robert Artificial insemination device
FR2597328A1 (fr) * 1985-08-19 1987-10-23 Agronomique Inst Nat Rech Instrument pour l'insemination artificielle, la transplantation d'embryons in utero ou le prelevement de liquides folliculaires, par voie transperitoneale, chez les animaux.
FR2651793B1 (fr) 1989-09-14 1991-12-06 Cassou Robert Tubes ou paillettes pour la conservation cryogenique d'echantillons biologiques tels que virus, et procede de remplissage.
US5261881A (en) 1990-03-28 1993-11-16 R. Myles Riner, M.D., Professional Corporation Non-reusable dispensing apparatus
US5195957A (en) 1991-02-01 1993-03-23 Tollini Dennis R Sterilant cartridge-cap and associated connection
CN2105940U (zh) * 1991-11-28 1992-06-03 武进县江南畜牧器材厂 一次性猪用输精器
US6305585B1 (en) * 1997-01-31 2001-10-23 Instruments De Medecine Veterinaire Filler nozzle for packaging for biological liquids, in particular for artificial insemination
FR2762210B1 (fr) 1997-04-21 1999-07-02 Instr Medecine Veterinaire Paillette avec un bouchon en fibre pleine microporeuse
FR2771284B1 (fr) 1997-11-24 2000-08-18 Instr Medecine Veterinaire Paillette avec insert adaptateur
FR2771285B1 (fr) 1997-11-24 2000-02-11 Instr Medecine Veterinaire Paillette avec bouchon bipartite
FR2784572B1 (fr) 1998-10-15 2001-02-09 Instr Medecine Veterinaire Procede de fabrication d'un element constitue d'un support et d'une membrane qui y est soudee, en particulier d'un bouchon de paillette, et ensemble membrane support obtenu par ce procede
US6516953B1 (en) * 1998-12-05 2003-02-11 Becton, Dickinson And Company Device for separating components of a fluid sample
FR2787717B1 (fr) 1998-12-24 2001-04-20 Aguettant Lab Injecteur et ampoule en matiere synthetique
FR2824256B1 (fr) 2001-05-07 2004-04-02 Imv Technologies Paillette pour la conservation de petites quantites de substances, en particulier de liquides biologiques
FR2824255B1 (fr) 2001-05-07 2004-02-06 Imv Technologies Paillette pour la conservation de petites quantites de substances, notamment de liquides biologiques
US7879293B2 (en) * 2001-09-28 2011-02-01 Orasure Technologies, Inc. Sample collector and test device
FR2932064B1 (fr) 2008-06-06 2010-08-13 Imv Technologies Paillette pour la conservation d'une dose de substance a base liquide, notamment une substance biologique
EP2198804A1 (de) 2008-12-18 2010-06-23 IMV Technologies Stroh zur Konservierung einer vorbestimmten Dosis einer flüssigen Basissubstanz, insbesondere einer biologischen Substanz
CN201384592Y (zh) * 2009-04-27 2010-01-20 李海林 禽用输精枪套管
USRE48283E1 (en) * 2010-08-10 2020-10-27 Brad Stroud Method and apparatus to reduce the number of sperm used in artificial insemination of cattle
KR101254950B1 (ko) * 2010-09-29 2013-04-16 경상북도 (관련부서:경상북도축산기술연구소장) 수정란 동결 보관 스트로우용 플러그
FR2998473B1 (fr) 2012-11-28 2015-02-13 Imv Technologies Gaine sanitaire pour seringue d'insemination par paillette et son procede de fabrication
FR3004332B1 (fr) 2013-04-11 2018-03-02 Imv Technologies Paillette pour la conservation d'une dose predeterminee de substance a base liquide, notamment de la semence animale pure ou diluee

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
None *

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BR112017025219A2 (pt) 2018-08-07
US10987206B2 (en) 2021-04-27
WO2016193630A1 (fr) 2016-12-08
US20180110604A1 (en) 2018-04-26
EP3302351A1 (de) 2018-04-11
FR3036954A1 (fr) 2016-12-09
FR3036954B1 (fr) 2017-07-14
CN107708608B (zh) 2019-08-13
CN107708608A (zh) 2018-02-16

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