EP3295983A1 - Cathéter de piégeage, kit et procédé de préparation d'un cathéter de piégeage - Google Patents

Cathéter de piégeage, kit et procédé de préparation d'un cathéter de piégeage Download PDF

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Publication number
EP3295983A1
EP3295983A1 EP16189746.7A EP16189746A EP3295983A1 EP 3295983 A1 EP3295983 A1 EP 3295983A1 EP 16189746 A EP16189746 A EP 16189746A EP 3295983 A1 EP3295983 A1 EP 3295983A1
Authority
EP
European Patent Office
Prior art keywords
catheter
trapping
guide
balloon
guide catheter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP16189746.7A
Other languages
German (de)
English (en)
Inventor
Peter Den Heijer
Edwin Alexander Schulting
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IMDS R&D BV
Original Assignee
IMDS R&D BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IMDS R&D BV filed Critical IMDS R&D BV
Priority to EP16189746.7A priority Critical patent/EP3295983A1/fr
Priority to PL17785036.9T priority patent/PL3515543T3/pl
Priority to PCT/NL2017/050620 priority patent/WO2018056807A1/fr
Priority to CN201780070497.6A priority patent/CN110072587B/zh
Priority to US16/334,854 priority patent/US11241558B2/en
Priority to JP2019536808A priority patent/JP7121015B2/ja
Priority to EP17785036.9A priority patent/EP3515543B1/fr
Priority to ES17785036T priority patent/ES2930066T3/es
Publication of EP3295983A1 publication Critical patent/EP3295983A1/fr
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/0169—Exchanging a catheter while keeping the guidewire in place
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/10—Tube connectors; Tube couplings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M2025/0183—Rapid exchange or monorail catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/06—Body-piercing guide needles or the like
    • A61M25/0662—Guide tubes
    • A61M2025/0681—Systems with catheter and outer tubing, e.g. sheath, sleeve or guide tube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09—Guide wires
    • A61M2025/09125—Device for locking a guide wire in a fixed position with respect to the catheter or the human body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M2025/1043—Balloon catheters with special features or adapted for special applications
    • A61M2025/1061—Balloon catheters with special features or adapted for special applications having separate inflations tubes, e.g. coaxial tubes or tubes otherwise arranged apart from the catheter tube

Definitions

  • the invention relates to a trapping catheter for maintaining an elongated device, such as a guidewire, in a position in a guide catheter, to a kit for preparing such a trapping catheter and to a method for preparing a trapping catheter prior to insertion into a guide catheter.
  • Most dilatation catheters used in angioplasty have an inflatable balloon at the distal end thereof. Using fluoroscopy for following the progress of the catheter, the catheter is advanced through the vascular system until the balloon is positioned across a stenosis to be treated. The balloon is then inflated via an inflation lumen communicating with the balloon. The inflation of the balloon causes stretching of the artery and pressing of the lesion into the artery wall to re-establish acceptable blood flow through the artery. A stent may be expanded simultaneously to provide scaffolding to the treated lesion.
  • the dilatation catheter is usually advanced along a guidewire that has previously been navigated to a position extending to or through the lesion to be treated.
  • a guidewire support catheter may be advanced over a guidewire to impart stiffness to the guidewire in predetermined areas to facilitate navigation of the distal end of the guidewire to the stenosis and for crossing the stenosis.
  • Dilatation catheters used are "over-the-wire" catheters which have a guidewire lumen over the entire length thereof or "rapid exchange" catheters which have a guidewire lumen close to the distal end only.
  • Use of such equipment involves exchanging a catheter for a different one for a different purpose, e.g. exchanging a guidewire support catheter for a dilatation catheter or exchanging a dilatation catheter for another one, e.g. with a balloon of a different size.
  • European patent application 0 415 332 describes the use of a trapping balloon that allows the operator to remove or exchange over the (guide)wire equipment safely and quickly. During catheter exchanges, this prevents inadvertent distal movement of guidewires. Guidewires designed to cross a stenosis are usually relatively stiff and can therefore perforate or otherwise damage a vessel of a patient easily. Maintaining the position of the distal end also ensures that the distal end is not accidentally pulled back, which would result in the need of renewed navigating to and/or traversing through the occlusion.
  • Trapping is achieved by first withdrawing the over-the-wire device on the guidewire several centimeters back into the guide catheter.
  • a trapping catheter having a balloon at its distal end is arranged in the guide catheter having its balloon at or near the distal end of the guide catheter and distally beyond the partially withdrawn equipment.
  • the balloon is preferably not advanced out of the end of the guide catheter, since this would entail a serious risk of traumatizing the proximal coronary artery.
  • visualization of the balloon catheter can be difficult and requires additional imaging and attention.
  • the trapping balloon is left inflated, so that the newly inserted device can be advanced quickly until it abuts the balloon without reverting to fluoroscopy for monitoring its advancement through the guide catheter.
  • the trapping balloon is then deflated and the newly inserted device can be advanced further into the coronary artery to the desired position, starting from a known position close to the distal end of the guide catheter.
  • this object is achieved by providing a trapping catheter according to claim 1.
  • the invention can also be embodied in a kit according to claim 1, in a system according to claim 13 and in a method according to claim 14.
  • the trapping catheter body is provided with a stopper for abutting against an abutment at the proximal end of the guide catheter assembly, e.g. a proximal end of a Y-connector or other fitting in a fixed position at the proximal end of the guide catheter assembly, so as to determine a maximum insertion depth of the trapping catheter into the guide catheter, the operator can insert the trapping catheter quickly into the guide catheter until the stopper abuts against the abutment, while it is ensured that the distal end of the trapping catheter is inside the guide catheter and directly adjacent to or at least close to the distal end of the guide catheter.
  • the invention is first described with reference to a first example shown in Figs. 1 and 2 .
  • a vascular system 1 and a first example of a catheter system 2 according to the invention are shown.
  • the guide catheter system 2 includes a guide catheter assembly 3 comprising a guide catheter 9 and a valve fitting 15 mounted to a proximal end of the guide catheter 9, and a trapping catheter 10.
  • the guide catheter 9 has been inserted into the vascular system 1, for instance via the femoral artery (not shown).
  • a distal portion of the vascular system 1, shown in Fig. 1 includes a descending aorta 4, an arch of aorta 5, and an ascending aorta 6.
  • a coronary artery 7 extends from the ascending aorta 6.
  • a stenosis 8 is formed in the coronary artery 7.
  • a guidewire 11 and a guidewire support catheter 12 extend inside the guide catheter 9.
  • the trapping catheter 10 has been marked with a dotted pattern.
  • the guidewire support catheter 12 is passed over the guidewire 11.
  • the valve fitting 15 is a Y-connector with hemostatic valves.
  • the guide catheter 9 is inserted into the vascular system 1 at the femoral artery (not shown) and advanced until a distal end 17 of the guide catheter 9 has reached a position projecting into a mouth portion 18 of the coronary artery 7. Then, the guidewire 11 and the guidewire support catheter 12 arranged over the guidewire 11 are inserted into the guide catheter 9.
  • the guidewire 11 may be inserted first followed by the guidewire support catheter 12 passing over the guidewire 11. Then, the combination of the guidewire 11 and the guidewire support catheter 12 are advanced until both extend out of the distal end 17 of the guide catheter 2. The tip of the guidewire 11 is then navigated to the stenosis 8 and across the stenosis 8. Advancement of the guidewire 11 and of the guidewire support catheter 12 may be alternated as required when flexibility or stiffness is required.
  • the trapping catheter 10 has a trapping catheter body 23, a balloon 22 adjacent to its distal end 21 and an inflation lumen 24 bounded by the trapping catheter body 23.
  • the inflation lumen 24 has a distal end 25 opening into an internal space bounded by the balloon 22.
  • the trapping catheter 10 is shown in a position inserted into the guide catheter 9 at the femoral artery (not shown) and advanced until the distal end 21 is at most flush with the distal end 17 of the guide catheter 9.
  • the distal end 21 of the trapping catheter 10 is preferably not advanced beyond a position slightly proximal of the distal end 21 of the guide catheter 9.
  • the guidewire 11 is held longitudinally positioned by engaging a proximal portion of the guidewire 11 projecting out of the guide catheter 9 so that the position of the distal end 20 of the guidewire 11 relative to the stenosis 8 is maintained.
  • the guidewire support catheter 12 to be exchanged is shown in a position retracted until its distal end 19 is proximal of the balloon 22 of the trapping catheter 10.
  • the balloon 22 of the trapping catheter 10 is inflated via the lumen 24 extending through the trapping catheter body 23 of the trapping catheter 10 so that it clamps the guidewire 11 against an inner wall surface of the guide catheter 9, thereby fixing the guidewire 11 relative to the guide catheter 9 and relative to the stenosis 8.
  • the proximal end of the guidewire 11 can be released and the dilatation catheter 12 can be pulled out of the guide catheter 9 and off of the proximal end of the guidewire 11. Since the guidewire 11 is fixed relative to the guide catheter 9, manipulating the dilatation catheter 12 off of the guidewire 11 entails very little risk of dislodgement of the distal end 20 of the guidewire 11.
  • another equipment such as a dilatation catheter may be placed on the proximal end of the guidewire 11 and be passed over the guidewire 11 into and through the guide catheter 9 until its distal end 19 abuts against the balloon 22 of the trapping catheter 10. Then, the proximal end of the guidewire 11 is again engaged to control its position via that proximal end and the balloon 22 of the trapping catheter 10 is deflated, thereby releasing the guidewire 11 where it was clamped between the balloon 22 of the trapping catheter 10 and the internal surface of the guide catheter 9.
  • a dilatation catheter may be placed on the proximal end of the guidewire 11 and be passed over the guidewire 11 into and through the guide catheter 9 until its distal end 19 abuts against the balloon 22 of the trapping catheter 10. Then, the proximal end of the guidewire 11 is again engaged to control its position via that proximal end and the balloon 22 of the trapping catheter 10 is deflated, thereby releasing the guidewire 11 where it was clamped between
  • the newly inserted dilatation catheter 12 is then moved distally along the guidewire 11 over a short distance, starting from an accurately defined position determined by the position of a proximal end of the balloon 22 of the trapping catheter 10, towards the stenosis 8. Since the distal end of the newly inserted catheter is advanced from an accurately defined position close to the distal end 17 of the guide catheter 9, and thus close to the stenosis 8, positioning a balloon of the dilatation catheter 12 in the stenosis 8 can be carried out very quickly. After the balloon of the dilatation catheter has been positioned across the stenosis 8, the stenosis 8 can be dilated by inflating the balloon of the dilatation catheter.
  • the position of the guidewire 11 in its longitudinal direction is reliably maintained relative to the guide catheter 9 and relative to the stenosis 8, without requiring particular attention and holding the guidewire by hand.
  • the new catheter can be inserted to a predetermined location near the distal end of the guide catheter 9 very quickly. Accordingly, also exposure to x-ray fluoroscopy is limited since the guidewire 11 is held stationary by the inflated balloon 22 of the trapping catheter and thus its position need not be continuously observed.
  • the trapping catheter body 23 of the trapping catheter 10 is provided with a stopper 26 for abutting against an abutment 27 at a proximal end 27 of the guide catheter assembly 3 so as to determine a maximum insertion depth of the trapping catheter 10 into the guide catheter 9.
  • the abutment is formed by a proximal end 27 of a Y-connector 15 with hemostasis valves at a proximal end of the guide catheter 9.
  • the position of the distal end 21 of the trapping catheter 10 in the guide catheter 9 is predetermined very accurately and reached by inserting the trapping catheter 10 into the guide catheter assembly 3 as far as possible until the stopper 26 hits the abutment 27, without requiring particular attention during advancement of the trapping catheter 10.
  • the stopper 26 is clamped to the Y-connector 15 of the guide catheter assembly 3.
  • the maximum insertion depth of the trapping catheter 10 for use in a guide catheter 9 of a given length is such that, in maximally inserted condition, the distal end 21 of the trapping catheter 10 is located within the guide catheter 9 at less than 50 mm, or, in order of increasing preference, at less than 40, 30, 20 or 10 mm from the distal end 17 of the guide catheter 9.
  • the trapping catheter body 23 with a stopper 26 for abutting against an abutment 27 at a proximal end of the guide catheter assembly 3 so as to determine a maximum insertion depth of the trapping catheter 10 such that, in maximally inserted condition, a distal end of the trapping catheter 10 is located within the guide catheter 9 at less than 50 mm (or less than 40, 30, 20 or 10 mm) from a distal end 17 of the guide catheter 9.
  • the stopper 26 has a hook 28 for hooking behind a part 29 of the valve fitting 15 of the guide catheter assembly 3, so that also the risk of inadvertent retracting movement of the trapping catheter 10, e.g. just before inflation of its balloon 22, is reduced.
  • guide catheters are mainly provided in lengths from balloon tip to proximal guide catheter end of 90 and 100 cm.
  • the Y-connector, hemostasis valve or other valve fitting 15 adds to the total length of the passage through the guide catheter assembly 3.
  • the stopper 26 is preferably positioned for limiting the insertion depth of the trapping catheter 10 (measured from distal end to the stopper) to at most 98-103 cm or to at most 108-113 cm and more preferably to at most 101-103 cm or at most 111-113 cm.
  • the balloon 22 of the trapping catheter 10 preferably has diameter of 2-3 mm or less when in expanded condition.
  • the balloon 22 of the trapping catheter 10 preferably has a length of 15-35 mm.
  • the stopper 26 projects further to one radial side of the trapping catheter body 23 than to an opposite side of trapping catheter body 23.
  • obstruction of a proximal entry area of the valve fitting 15 is limited to a small area.
  • This feature is particularly effective if, as in the example shown in Fig. 3 , the stopper 76 projects to one radial side of the trapping catheter body 73 of the trapping catheter 60 only.
  • a stopper 76 projecting to one radial side of the trapping catheter body 73 of the trapping catheter 10 only is obtained in a particularly simple manner by providing that the stopper 76 includes a curved section 77 of the trapping catheter body 73 of the trapping catheter 60.
  • the curved portion 77 preferably has a radius of less than 5 mm and more preferably of less than 3 or 4 mm and/or the curved portion 77 is curved over an angle of deflection of at least 30° and more preferably at least 45°.
  • the trapping catheter body may be bent in other directions, for instance bent back to a direction generally parallel to the part on the other side of the curved portion.
  • the position of the stopper can be set in accordance with the length of the guide catheter, only a single version of the trapping catheter is sufficient for use in combination with guide catheters of different lengths.
  • a kit for preparing a trapping catheter including a trapping catheter 60 for insertion into a guide catheter 59, the trapping catheter 60 having a balloon and a trapping catheter body 73 in which a sheath 80 is removably mounted to the trapping catheter body 73.
  • the sheath 73 is positioned for forming the curved portion 77 by bending a section of the trapping catheter body 73 in a weakened section or an interruption of the sheath 80.
  • the sheath may also be positioned for forming the curved portion 77 adjacent to an end of the sheath 80.
  • the curved portion can be made particularly quickly and reliably in the right position.
  • the sheath 80 encloses a portion of the trapping catheter body 73 adjacent to the section that is to be curved, so that it is ensured that the portions of the trapping catheter body 73 adjacent to the portion to be bent is not significantly curved after the bend has been made, and the portion to be bent can be bent easily by hand without requiring any further tools.
  • the width of the slot 81 is such that the trapping catheter body 73 of the trapping catheter 60 is held in the channel 82, but the tubular member can be removed from the trapping catheter body 73 in a direction transverse to the trapping catheter body 73 and to the tubular member 80.
  • the tubular member 80 has a weakening in the form of mutually opposite recesses 83, 84.
  • a first one of these recesses 83 is of a V-shape having an intersection of opposite sidewalls approximately in line with a center line of the trapping catheter body 73 and a second one of the recesses 84 is in the form of a reduced wall thickness over approximately the maximum width of the V-shaped recess for facilitating stretching of the sheath material.
  • a curved portion 77 can easily be made in a predetermined position determined by the position in which the sheath 80 has been pre-mounted to the trapping catheter body 73 of the trapping catheter 60, by hand without needing tools and without performing any measurements or referring to small marks present on the trapping catheter body 73 of the trapping catheter 60.
  • the sheath 80 also supports the trapping catheter body 73 evenly, so that the risk of collapsing of the internal lumen 74 of the trapping catheter body 73 is reduced.
  • the internal lumen 74 of the trapping catheter body preferably has a diameter of 0.4-0.9 mm and more preferably of 0.5-0.8 mm and the trapping catheter body 73 preferably has a diameter of less than 1.2 mm and more preferably less than 1.0 mm.
  • the position of the stopper 76 can be determined just before use, by bending over one of the sheaths 80 that is selected in accordance with the required maximum insertion depth.
  • the other sheath 80 is simply removed from the trapping catheter body 73 without bending at the position of that sheath.
  • the insertion depth may also be adapted by bending at predetermined markings, which may be removable from the trapping catheter or not. This also allows adapting the maximum insertion depth of the trapping catheter to the effective length added by the valve fitting.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Media Introduction/Drainage Providing Device (AREA)
EP16189746.7A 2016-09-20 2016-09-20 Cathéter de piégeage, kit et procédé de préparation d'un cathéter de piégeage Withdrawn EP3295983A1 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP16189746.7A EP3295983A1 (fr) 2016-09-20 2016-09-20 Cathéter de piégeage, kit et procédé de préparation d'un cathéter de piégeage
PL17785036.9T PL3515543T3 (pl) 2016-09-20 2017-09-20 Cewnik typu trapping i zestaw oraz sposób przygotowania cewnika typu trapping
PCT/NL2017/050620 WO2018056807A1 (fr) 2016-09-20 2017-09-20 Cathéter de piégeage et kit et procédé de préparation d'un cathéter de piégeage
CN201780070497.6A CN110072587B (zh) 2016-09-20 2017-09-20 捕获导管和用于制备捕获导管的套件和方法
US16/334,854 US11241558B2 (en) 2016-09-20 2017-09-20 Trapping catheter and kit and method for preparing a trapping catheter
JP2019536808A JP7121015B2 (ja) 2016-09-20 2017-09-20 捕捉カテーテル並びに捕捉カテーテルを準備するためのキット及び方法
EP17785036.9A EP3515543B1 (fr) 2016-09-20 2017-09-20 Cathéter de piégeage, kit et procédé de préparation d'un cathéter de piégeage
ES17785036T ES2930066T3 (es) 2016-09-20 2017-09-20 Catéter de atrapamiento y kit y método para preparar un catéter de atrapamiento

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16189746.7A EP3295983A1 (fr) 2016-09-20 2016-09-20 Cathéter de piégeage, kit et procédé de préparation d'un cathéter de piégeage

Publications (1)

Publication Number Publication Date
EP3295983A1 true EP3295983A1 (fr) 2018-03-21

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Application Number Title Priority Date Filing Date
EP16189746.7A Withdrawn EP3295983A1 (fr) 2016-09-20 2016-09-20 Cathéter de piégeage, kit et procédé de préparation d'un cathéter de piégeage
EP17785036.9A Active EP3515543B1 (fr) 2016-09-20 2017-09-20 Cathéter de piégeage, kit et procédé de préparation d'un cathéter de piégeage

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP17785036.9A Active EP3515543B1 (fr) 2016-09-20 2017-09-20 Cathéter de piégeage, kit et procédé de préparation d'un cathéter de piégeage

Country Status (7)

Country Link
US (1) US11241558B2 (fr)
EP (2) EP3295983A1 (fr)
JP (1) JP7121015B2 (fr)
CN (1) CN110072587B (fr)
ES (1) ES2930066T3 (fr)
PL (1) PL3515543T3 (fr)
WO (1) WO2018056807A1 (fr)

Cited By (1)

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US10617847B2 (en) 2014-11-04 2020-04-14 Orbusneich Medical Pte. Ltd. Variable flexibility catheter support frame

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Publication number Priority date Publication date Assignee Title
WO2021141485A1 (fr) 2020-01-07 2021-07-15 Imds R&D B.V. Ensemble cathéter comprenant un cathéter d'extension de guidage et un cathéter à ballonnet de piégeage.

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US11241558B2 (en) 2022-02-08
WO2018056807A1 (fr) 2018-03-29
CN110072587B (zh) 2021-06-25
US20200016372A1 (en) 2020-01-16
ES2930066T3 (es) 2022-12-05
JP2019529035A (ja) 2019-10-17
EP3515543B1 (fr) 2022-11-02
JP7121015B2 (ja) 2022-08-17
CN110072587A (zh) 2019-07-30
EP3515543A1 (fr) 2019-07-31
PL3515543T3 (pl) 2022-12-27

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