EP3280420A4 - Compositions et méthodes permettant de traiter des troubles du snc - Google Patents

Compositions et méthodes permettant de traiter des troubles du snc Download PDF

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Publication number
EP3280420A4
EP3280420A4 EP16777382.9A EP16777382A EP3280420A4 EP 3280420 A4 EP3280420 A4 EP 3280420A4 EP 16777382 A EP16777382 A EP 16777382A EP 3280420 A4 EP3280420 A4 EP 3280420A4
Authority
EP
European Patent Office
Prior art keywords
compositions
methods
cns disorders
treating cns
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP16777382.9A
Other languages
German (de)
English (en)
Other versions
EP3280420A1 (fr
EP3280420B1 (fr
Inventor
Albert Jean Robichaud
Francesco G. Salituro
Gabriel Martinez Botella
Boyd L. Harrison
Jeffrey Jonas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sage Therapeutics Inc
Original Assignee
Sage Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sage Therapeutics Inc filed Critical Sage Therapeutics Inc
Publication of EP3280420A1 publication Critical patent/EP3280420A1/fr
Publication of EP3280420A4 publication Critical patent/EP3280420A4/fr
Application granted granted Critical
Publication of EP3280420B1 publication Critical patent/EP3280420B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
EP16777382.9A 2015-04-10 2016-04-08 Compositions et méthodes permettant de traiter des troubles du snc Active EP3280420B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562146034P 2015-04-10 2015-04-10
US201562196591P 2015-07-24 2015-07-24
US201662280825P 2016-01-20 2016-01-20
PCT/US2016/026705 WO2016164763A1 (fr) 2015-04-10 2016-04-08 Compositions et méthodes permettant de traiter des troubles du snc

Publications (3)

Publication Number Publication Date
EP3280420A1 EP3280420A1 (fr) 2018-02-14
EP3280420A4 true EP3280420A4 (fr) 2018-11-21
EP3280420B1 EP3280420B1 (fr) 2024-03-27

Family

ID=57072142

Family Applications (1)

Application Number Title Priority Date Filing Date
EP16777382.9A Active EP3280420B1 (fr) 2015-04-10 2016-04-08 Compositions et méthodes permettant de traiter des troubles du snc

Country Status (3)

Country Link
US (2) US20180311258A1 (fr)
EP (1) EP3280420B1 (fr)
WO (1) WO2016164763A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016082789A1 (fr) 2014-11-27 2016-06-02 Sage Therapeutics, Inc. Compositions et procédés pour traiter des troubles du snc
WO2018147791A1 (fr) * 2017-02-10 2018-08-16 Asarina Pharma Ab 3-bêta-hydroxy-5-alpha-prégnan-20-one destinée à être utilisée dans le traitement des tremblements essentiels
CN110430883A (zh) 2017-02-10 2019-11-08 阿沙里那制药公司 用于医学治疗的3β-羟基-5α-孕烷-20-酮
KR20200104350A (ko) * 2017-12-22 2020-09-03 세이지 테라퓨틱스, 인크. Cns 장애의 치료를 위한 조성물 및 방법
EP3712161A1 (fr) * 2019-03-19 2020-09-23 Bionice, S.L.U. Procédé de préparation d'alloprégnanolone haute pureté et intermédiaires correspondants
US10857163B1 (en) 2019-09-30 2020-12-08 Athenen Therapeutics, Inc. Compositions that preferentially potentiate subtypes of GABAA receptors and methods of use thereof
CN113061070A (zh) * 2021-03-29 2021-07-02 阿尔塔(天津)标准物质研究院有限公司 一种氘标记的美替诺龙稳定性同位素标记化合物
WO2023083979A1 (fr) * 2021-11-10 2023-05-19 Umecrine Ab STÉROÏDES 3β-HYDROXY, 3α-ÉTHYLE POUR LA MODULATION DU SOUS-TYPE α3 DU RÉCEPTEUR GABA-A
CN114956930B (zh) * 2022-05-11 2023-12-29 仙琚(嘉兴)医药科技有限公司 5β-甾体结构化合物的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013112605A2 (fr) * 2012-01-23 2013-08-01 Sage Therapeutics, Inc. Formulation de stéroïde neuroactif et procédés de traitement des troubles de snc
WO2014085668A1 (fr) * 2012-11-30 2014-06-05 The Regents Of The University Of California Activité anticonvulsivante des stéroïdes
WO2016040322A1 (fr) * 2014-09-08 2016-03-17 Sage Therapeutics, Inc. Stéroïdes neuroactifs, leurs compositions et utilisations

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2526373C2 (de) * 1975-06-11 1983-11-10 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur Herstellung von Δ↑9↑↑(↑↑1↑↑1↑↑)↑-5α-20-Ketosteroiden
US5232917A (en) 1987-08-25 1993-08-03 University Of Southern California Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
BR9507200A (pt) * 1994-03-25 1997-09-16 Isotechnika Inc Melhora da eficácia de drogas por deuteração
US6376531B1 (en) * 1998-11-13 2002-04-23 Rupert Charles Bell Method of treatment using deuterium compounds
DE60001623T2 (de) * 1999-12-03 2003-12-18 Pfizer Prod Inc Sulfamoylheteroarylpyrazolverbindungen zur Verwendung als analgetisches/entzündungshemmendes Mittel
CA3152410A1 (en) * 2011-10-14 2013-04-18 Sage Therapeutics, Inc. 3,3-disubstituted 19-nor pregnane compounds, compositions, and uses thereof for the treatment of cns related disorders
LT3021852T (lt) * 2013-07-19 2021-04-12 Sage Therapeutics, Inc. Neuroaktyvūs steroidai, jų kompozicijos ir panaudojimas
WO2015134670A1 (fr) * 2014-03-05 2015-09-11 Mingbao Zhang Dérivés deutérés du ganaxolone

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013112605A2 (fr) * 2012-01-23 2013-08-01 Sage Therapeutics, Inc. Formulation de stéroïde neuroactif et procédés de traitement des troubles de snc
WO2014085668A1 (fr) * 2012-11-30 2014-06-05 The Regents Of The University Of California Activité anticonvulsivante des stéroïdes
WO2016040322A1 (fr) * 2014-09-08 2016-03-17 Sage Therapeutics, Inc. Stéroïdes neuroactifs, leurs compositions et utilisations

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J VINE ET AL: "2H-labelled 3[alpha]-hydroxy-5[alpha]-pregnane-11,20-dione and 3[alpha],21-dihydroxy-5[alpha]-pregnane-11,20-dione 21-acetate", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, 1 April 1982 (1982-04-01), pages 597 - 604, XP055516145, Retrieved from the Internet <URL:https://onlinelibrary.wiley.com/doi/pdf/10.1002/jlcr.2580190414> DOI: 10.1002/jlcr.2580190414 *
JOHNSON D W ET AL: "Deuterium labelled steroid hormones: Syntheses and applications in quantitation and endocrinology", JOURNAL OF STEROID BIOCHEMISTRY, PERGAMON PRESS PLC, GB, vol. 14, no. 8, 1 August 1981 (1981-08-01), pages 793 - 800, XP023415677, ISSN: 0022-4731, [retrieved on 19810801], DOI: 10.1016/0022-4731(81)90017-0 *

Also Published As

Publication number Publication date
EP3280420A1 (fr) 2018-02-14
US20210113590A1 (en) 2021-04-22
WO2016164763A1 (fr) 2016-10-13
US20180311258A1 (en) 2018-11-01
WO2016164763A8 (fr) 2016-11-03
EP3280420B1 (fr) 2024-03-27

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