EP3250172B1 - Dispositif de transfert d'un liquide entre un récipient de stockage et au moins récipient d'utilisation - Google Patents
Dispositif de transfert d'un liquide entre un récipient de stockage et au moins récipient d'utilisation Download PDFInfo
- Publication number
- EP3250172B1 EP3250172B1 EP16702677.2A EP16702677A EP3250172B1 EP 3250172 B1 EP3250172 B1 EP 3250172B1 EP 16702677 A EP16702677 A EP 16702677A EP 3250172 B1 EP3250172 B1 EP 3250172B1
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- EP
- European Patent Office
- Prior art keywords
- transfer device
- storage container
- hollow needle
- hollow
- container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2048—Connecting means
- A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1412—Containers with closing means, e.g. caps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2006—Piercing means
- A61J1/201—Piercing means having one piercing end
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2048—Connecting means
- A61J1/2055—Connecting means having gripping means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2079—Filtering means
- A61J1/2082—Filtering means for gas filtration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
Definitions
- the invention relates to a device for transferring a liquid between a storage container and at least one further use container according to the preamble of claim 1. Furthermore, the invention relates to a set of such a transfer device and a storage container.
- Such devices are known from the WO 2011/088471 A1 , from the WO 2014/152249 A1 , from the WO 98/32411 A1 , from the US 6,209,738 B1 , from the US 6,537,263 B1 , from the US 5,879,345 and from the WO 2012/119225 A1 ,
- the WO 2014/170888 A1 discloses a transfer device comprising a fluid transfer element with a hollow needle. From the EP 1 093 784 A2 Different transfer devices are known, the hollow needles are displaced by relative rotation between a closure and a hollow needle holder.
- the WO 2014/033710 A1 discloses transfer devices for transferring a liquid between a liquid container and a container.
- Such a device can be used in particular as a reconstitution device.
- the storage container can then be a powdered drug, which is first mixed with the transfer device in the connection position on the then connected utility container with a solvent and then transferred via the transfer device in the same or another use container in dissolved form for further use , Irreversibility of the displacement, induced by the guide means, ensures that the transfer device can be used just once. An originality of the transfer device is thus ensured. This is particularly advantageous in a medical application of the transfer device.
- An embodiment of the guide groove with a guide coil results in a controlled guidance of the pressure actuating element when releasing the main body of the transfer device.
- the guide pin can be integrally formed on a base body of the pressure actuator.
- the guide groove can be molded into the main body.
- a sawtooth-shaped profiled groove base gives the user a haptic and acoustic feedback of a displacement progress in the printing operation.
- the sawtooth-shaped profiling can ensure irreversibility of the displacement.
- a fuse element according to claim 5 prevents the pressure actuator is operated undesirable prior to the planned use.
- the advantages of a set according to claim 6 correspond to those in, the above reference to the transfer device according to the invention have already been explained.
- the set may also include at least one utility container, for example in the form of a standard syringe.
- Fig. 1 to 12 Based on Fig. 1 to 12 is a first embodiment of a device 1 for transferring a liquid between a storage container 2 (see. Fig. 6 ) and at least one further storage container 3 (see. Fig. 6 ). All moldings of the transfer device 1 are made of plastic and are designed in particular as injection-molded parts.
- the transfer device 1 has a sealing portion 4 for the sealing abutment of a base body 5 (see. Fig. 2 ) of the transfer device 1 on the storage container 2.
- the sealing portion 4 is applied to an elastomeric sealing plug of the storage container 2a, which will be described below.
- the sealing portion 4 engages around a neck 6 of the storage container 2 (see. Fig. 5 ).
- An outer locking sleeve 7 of the transfer device 1 is used to secure the sealing portion 4 in its sealing position.
- Fig. 1 shows the securing sleeve 7 in a transport position of the transfer device 1 prior to placement on the storage container 2.
- Fig. 6 shows the securing sleeve 7 in a pushed over the sealing portion 4 securing position, engage in the corresponding locking lug of the locking sleeve 7 in locking receptacles 8 of the sealing portion 4 and press this against the neck 6 of the storage container 2 sealing.
- the transfer device 1 further has a hollow needle assembly 9 with a hollow needle 10 and a surrounding needle sleeve 11.
- the hollow needle 10 is designed as a plastic hollow needle.
- the hollow needle 10 may also be designed at least in sections as a steel cannula. Through the hollow needle 10 there is a liquid transfer between the utility container 3 and the storage container 2 and at the same time a ventilation of these containers 2, 3, as will be explained in more detail below.
- the hollow needle assembly 9 is by means of a gear 12 relative to the main body 5 linearly along a movement axis 13 (see. Fig. 3 ) relocatable.
- This movement axis 13 extends coaxially to a central longitudinal axis 14 of the transfer device 1.
- a displacement of the hollow needle assembly 9 takes place between one example in the FIGS. 2 and 3 shown, retracted rest position and one example in the Fig. 5 shown, extended Connecting position.
- the hollow needle 10 provides, inter alia, a fluid connection channel between the storage container 2 and the transfer device 1.
- This liquid channel extends between a free needle end 15 and an opposite connection portion 16 (see. Fig. 5 ).
- the connecting portion 16 is an integral part of the hollow needle 10.
- the connecting portion 16 is for sealing the connection of the transfer device 1 with the use container 3 and is designed as a Luer connection.
- the use container 3 is designed as a standard syringe with a complementary Luer connection.
- the transfer device 1 may also be connected differently to the utility container 3, for example by way of another embodiment of a conical connection.
- the needle sleeve 11 is a separate component to the hollow needle 10.
- the needle sleeve 11 is circumferentially sealed to the hollow needle 10 at two axial positions, namely on the one hand in the region of the connecting portion 16 facing the end of the needle sleeve 11 (see Fig. 3 ) and on the other hand axially spaced at an opposite connecting portion 18. Between these connecting portions 17, 18 axially and between the hollow needle 10 and the needle sleeve 11 radially is an approximately hollow cylindrical annular space 19th
- the transfer device 1 further has a multi-part rotary actuator 20 which is connected via the gear 12 with the hollow needle assembly 9 in operative connection.
- the rotary actuator 20 has an annular cover 21 and an actuator base 22 (see, eg FIGS. 2 and 3 ).
- the rotary actuator 20 is rotatable relative to the main body 5 of the transfer device 1 about the central longitudinal axis 14.
- the actuator base body 22 is against the base body 5 of the transfer device 1 via a base seal 23 (see, for example Fig. 2 ) sealed. This creates a closed and in particular germ-tight space within the body.
- the rotary actuator 20 further includes an outer coupling sleeve 24 which is rotatably connected to the actuator base body 22 and can be understood as part of this body 22.
- the transmission 12 has an axially and about the central longitudinal axis 14 rotatably mounted in the base body 5 of the transfer device 1 driving ring 25. Radially, the driving ring 25 is located between the base body 5 and the needle sleeve 11th
- the driver ring 25 has an inner driver, which is designed as an internal thread 26 in the embodiment shown.
- the internal thread 26 interacts with a complementary thread 27, designed as external thread, the needle sleeve 11 for displacing the hollow needle assembly 9 together.
- the actuating element base body 22 has a plurality, for example three, axial projections 28 (cf., for example, FIG Fig. 3 ), which, as long as a rotationally fixed connection of the actuating element base body 22 with the driving ring 25, engage in associated axial receptacles 29 of the driving ring 25.
- the axial nose 28 and the associated axial receptacles 29 are distributed in the circumferential direction about the central longitudinal axis 14.
- the axial lugs 28 are integral parts of the actuator base body 22nd
- a rotation of the hollow needle assembly 9 is given relative to the base body 5 to the central longitudinal axis 14.
- the needle sleeve 11 to the axial ribs 30 complementary axial guide grooves 31 (see, eg Fig. 11a and 12 ).
- End faces 32 of these inner axial ribs 30 simultaneously represent an axial seat of the driving ring 25 in the main body 5 of the transfer device.
- the main body 5 of the transfer device 1 has a lift-off driver 33 designed as an external thread.
- the latter interacts with a counter-lift-off carrier 34, designed as a complementary internal thread, of the coupling sleeve 24 of the rotary actuating element 20.
- the interaction of the lift-off cam 33 with the counter-lifting-driver 34 leads to a lifting of the rotary actuator 20 from Basic body 5 of the transfer device 1 for relieving the main body seal 23rd
- Fig. 4 shows by way of example the correspondingly relieved position in which the actuator base body 22 is lifted off the main body 5 axially.
- the main body seal 23 may be designed as a silicone lamellar seal. Alternatively, the main body seal 23 may be designed as a hard / hard mechanical seal.
- the drivers 33, 34 are disengaged, so that the entire rotary actuator 20 from the main body 5 of the transfer device 1 is removable.
- the transfer device 1 additionally has a locking device 35 for locking the hollow needle assembly 9 in the connecting position. This locking is used to ensure the originality of the transfer device 1 by the displacement of the hollow needle assembly 9 is made irreversible in the connection position.
- the locking device 35 comprises a latching component 36 on the main body 5 of the transfer device 1, which cooperates with a detent counter-component 37 complementary thereto on the outer wall of the hollow needle 10 latching.
- Fig. 6 shows the transfer device 1 with the hollow needle assembly 9 in the connecting position with removed rotary actuator 20.
- the connecting portion 16 of the hollow needle assembly 9 is now accessible from above and not covered by the ring cover 21 of the rotary actuator 20. Due to this accessibility of the connecting portion 16, this can be connected to the Luer connector of the utility container 3.
- the storage container 2 is sealed in the region of its neck 6 by a stopper 38 in the form of an elastomeric sealing plug or a sealing membrane.
- a stopper 38 in the form of an elastomeric sealing plug or a sealing membrane.
- the liquid channel 39 already mentioned above in connection with the displacement of the hollow needle assembly 9 opens between the storage container 2 and the transfer device 1 via two liquid channel openings 40, 41 (cf. Fig. 10 ) outwards.
- the liquid channel 39 serves to transport liquid through the hollow needle 10.
- a ventilation gas channel 42 also opens out of the hollow needle 10 via a gas channel opening 43.
- the ventilation gas duct 42 serves to transport gas through the hollow needle assembly 9, namely for venting or venting the storage container 2 or the use container 3.
- the channel paths of the liquid channel 39 on the one hand and the gas channel 42 on the other hand are separated from each other.
- the liquid channel 39 on the one hand and the gas channel 42 on the other hand open axially along the hollow needle 10 adjacent to each other and in the circumferential direction about the central longitudinal axis 14 offset from each other.
- Between each one of the liquid channel openings 40, 41 and the circumferentially adjacent gas channel opening 43 extends in the longitudinal direction of the hollow needle 10 extending needle-separating edge 44, 45.
- Another, correspondingly extending in the longitudinal direction of the hollow needle 10 needle-separating edge 46 extends between the two liquid channel openings 40 and 41st
- the two needle-separating edges 44, 45 between the liquid channel openings 40, 41 and the gas channel opening 43 reduces undesirable liquid transfer between the liquid channel 39 and the vent gas channel 42.
- the needle-separating edges 44 to 46 serve for reduction of piercing forces of the hollow needle 12 in the sealing plug 38 of the storage container 2.
- the needle-separating edges 44 to 46 have a cutting action when puncture in the sealing plug 38th
- the liquid channel openings 40, 41 are axially at least as far away from the needle tip at the free needle end 15 as the gas channel opening 43. In the illustrated embodiment (see. Fig. 9 ), the liquid channel openings 40, 41 are axially further away from the needle tip at the free needle end 15 than the gas channel opening 43.
- a gas flow path through the ventilation gas channel 42 initially runs via a gas channel section 47, which runs parallel to the central longitudinal axis 14 in the hollow needle 10.
- the gas channel section 47 opens via a passage opening 48 (cf. Fig. 8a / b ) in the annular space 19 between the hollow needle 10 and the needle sleeve 11 from.
- the annular space 19 thus forms a portion of the ventilation gas channel 42.
- the needle sleeve 11 has a plurality of needle sleeve passage openings 49. In total, eight such needle sleeve passage openings 49 are arranged evenly distributed around the central longitudinal axis 14 around.
- the needle sleeve passage openings 49 provide a flow passage of the ventilation gas channel 42 between the annular space 19 and a further annular space 50 in a bottom side, ie the storage container 2 facing, portion of the needle sleeve 11 in this further annular space 50 is an annular disc-shaped filter carrier 51st arranged, which surrounds the hollow needle 10 annular.
- the filter support 51 carries a likewise annular air filter 52 of the transfer device 1.
- the transfer device 1 is used as follows: First, the transfer device 1 in the after Fig. 1 present configuration on the neck 6 of the storage container 2, in which an example powdered medicine is present, placed. Subsequently, the seal securing sleeve 7 is pushed over the sealing portion 4. As a result, the transfer device 1 is secured on the neck 6 of the storage container 2, wherein in particular a tamper-evident closure can be ensured. In addition, this sealing section 4 is secured by the sliding of the sealing safety sleeve 7 via the sealing section 4 and the transfer device 1 seals against the storage container 2.
- the rotary actuator 20 is rotated in the direction indicated by arrow symbols 53 on the outside of the ring cover 21 direction of rotation by 360 ° or an even larger angle of rotation.
- the driving ring 25 which, axially mounted in the base body 5, now also rotates about the central longitudinal axis 14, thereby axially displaced against the base body 5 but not.
- the driving ring 25 is secured over undercuts in the base body 5.
- the threads 26, 27 now begins the displacement of the hollow needle assembly 9 relative to the base body 5 in the direction of the movement axis 13, ie to the storage container 2 to.
- the threads 33, 34 of the main body 5 of the transfer device act 1 on the one hand and the coupling sleeve 24 on the other hand together, so that the actuator base body 22 stands out from the main body 5 of the transfer device 1 axially, as in the Fig. 4 shown.
- the hollow needle assembly 9 in the connection position after Fig. 5 displaces and pierces the plug 38 of the storage container 2. This happens until on the one hand the threads 26, 27 and on the other hand, the threads 33, 34 are disengaged from each other. In the connecting position, the locking device 35 is engaged and the hollow needle assembly 9 is irreversibly secured in this position.
- the entire rotary actuator 20 can be removed and the use of container 3, so the standard hypodermic syringe, can be connected via the Luer coupling with the connecting portion 16 of the transfer device 1.
- container 3 is a matched to the drug in the storage container 2 solvent.
- this solvent is injected by actuation of a syringe plunger of the use container 3 via the transfer device 1 into the interior of the storage container 2.
- the solvent flows through the liquid channel 39 in the hollow needle 10 and exits via the two liquid channel openings 40, 41 from the hollow needle 10 into the storage container 2.
- the arrangement of the liquid channel openings 40, 41 relative to the gas channel opening 43 reduces an overflow of liquid droplets in the gas channel during injection, since the liquid does not flow in the direction of gravity down and thus during injection in the direction of the gas channel.
- air escapes from the storage container 2 via the gas channel opening 43 through the ventilation gas channel 42 via the gas channel section 47, the passage opening 48, the annular space 19, the needle sleeve passage openings 49, the annular space 50 , the air filter 52 and from there between the needle sleeve 11 and the main body 5 of the transfer device 1 to the outside.
- a solution of the initially powdered medicament in the solvent is brought about by shaking the assembly from the storage container 2, the transfer device 1 and the utility container 3.
- the dissolved medicament flows via the liquid channel 39 through the hollow needle 10 to the storage container 2 into the use container 3.
- This flow of the dissolved medicament into the use container 3 is produced by mounting the use container 3 designed as a syringe. Transferring the dissolved medicament from the storage container 2 into The use of container 3 is usually in over-head position, in which the storage container 2 is disposed above the utility container 3.
- the liquid channel openings 40, 41 are closer to a residual solution of the dissolved drug, so that a residual emptying of the solution is improved.
- the gas channel opening 43 is further away from the remainder of the solution in this overhead position than the liquid channel openings 40, 41, so that the gas channel can perform its ventilation function well.
- air flows through the ventilation gas channel 42 from the environment around the transfer device 1 through the air filter 52 into the storage container 2.
- the inflowing air is sterile-filtered by the air filter 52.
- Fig. 13a and 13b show a variant of a hollow needle assembly 54, which can be used instead of the hollow needle assembly 9 in the transfer device 1.
- an axial channel body 55 is disposed in the annular space 19. This is designed so that a reversal of the direction of the vent gas channel 42 is not, as in the execution of the Fig. 1 to 12 , in the bottom side, the storage container 2 facing region of the annular space 19 takes place, but approximately at an axial height A of about two-thirds of the total axial height of the annular space 19.
- the axial channel body 55 effectively suppresses unwanted entrainment of liquid along the entire vent gas channel 42.
- the path of the gas through the gas channel 42 during venting of the storage container 2 is in the Fig. 13a indicated by a directional arrow 55a.
- the axial channel body 55 is designed as up to a height of two-thirds of the entire axial height of the annular space 19 sealed sub-segment between the hollow needle 10 and the needle sleeve 11.
- the passage openings 48 are closed so that an ascent of the air flowing out of the storage container 2 is forced upon injection of the liquid into the storage container 2. The air then flows after the rise and the direction reversal through the remaining openings 48 of the unlocked segment.
- inflowing liquid droplets are additionally distributed or deposited by gravity.
- FIG. 14 ff. Another embodiment of a transfer device 56, which instead of the transfer device 1 after the Fig. 1 to 13a / b can be used, is described below on the basis of Fig. 14 ff. described. Components and functions that correspond to those referred to above Fig. 1 to 13a / b have already been described, bear the same reference numbers or designations and will not be discussed again in detail.
- Fig. 14 shows the transfer device 56 after placement on the storage container 2 and before moving the seal securing sleeve. 7
- Fig. 15 shows the transfer device 56 after moving the seal securing sleeve 7 in the securing position for the sealing portion. 4
- Fig. 16 shows the transfer device 56 in a transport configuration.
- this transport configuration is displaced in the securing position seal-securing sleeve 7 between this and a head portion 57 of a pressure-actuating element 58 of the transfer device 56 a removable securing element 59 introduced in the form of a locking half-ring.
- the securing element 59 is in a circumferential receiving groove 60 (see. Fig. 15 ) of the head portion 57 of the pressure actuator 58 is inserted.
- the securing element 59 prevents a displacement of the pressure actuating element 58 relative to a base body 61 (cf. Fig. 17 ) of the transfer device 56 in the direction of the storage container 2 to. An unintentional pressure actuation of the pressure actuating element 58 is thus prevented.
- the hollow needle assembly 62 apart from an outer geometry of the needle sleeve 11 constructed as the hollow needle assembly 9.
- the outer geometry of the needle sleeve 11 of the embodiment according to the Fig. 14 ff. Is designed for a pushing movement and thus eg without the thread 27.
- the design of the hollow needle assembly 62 with respect to the liquid channel and the ventilation gas channel as in the hollow needle assembly 9 in connection with the Fig. 1 to 12 has already been explained.
- a guide device 64 For axial guidance of the pressure actuator 58 on the base body 61 in the displacement of the hollow needle assembly 62 from the rest position to the connecting position is a guide device 64.
- the latter has two guide pins 65 which are integrally formed on an inner side of a jacket wall of the pressure-actuating element 58.
- the guide pins 65 slide during the relocation from the rest position into the connecting position, in each case in an assigned guide groove 66, which is embodied in an outer wall of the main body 61 of the transfer device 56.
- the guide device 64 is designed such that the displacement of the hollow needle assembly 62 from the rest position to the connecting position is irreversible.
- the two guide grooves 66 each have a sawtooth profiled groove base 67, which in the Fig. 19 in cross-section and in the Fig. 20a / b is shown for one of the two guide grooves 66 in a perspective view.
- the profiling of saw teeth in groove base 67 is such that the guide pin 65 can slide on the displacement of the pressure actuating element 58 from the rest position into the connecting position on inclined surfaces of the saw teeth. In the connecting position, a sliding back of the guide pin 65 in the guide grooves 66 upwards is not possible, since the guide pins 65 are then blocked by vertical surfaces of the sawtooth profiling.
- the guide grooves 66 each continue into a guide helix 68.
- a twisting of the pressure-actuating element 58 from the main body 61 of the transfer device 56 is possible, as indicated by directional arrows 69, 70 in the Fig. 20a / b indicated.
- the guide pins 65 of the pressure-actuating element 58 slide in each case in one of the two guide spirals 68 on the outside of the main body 61 of the transfer device 56 until the guide pin 65 at the end of the guide spirals 68 out of engagement with the main body 61.
- the transfer device 56 After removal of the pressure actuator 58, the transfer device 56 is in the instantaneous position, which in the Fig. 21 is shown. In this instantaneous position, the connecting portion 16 of the hollow needle 63 is accessible from above, as described in connection with the transfer device 1 and the Fig. 6 has already been explained.
- the transfer device 56 is used as follows: After installation, the transfer device 56 is located together with the storage container 2, in which the powdered medicament is kept, first in the in the Fig. 16 shown transport position with inserted securing element 59 before.
- the securing element 59 When using the transfer device 56, the securing element 59 is first withdrawn. Then, pressure is applied to an upper end surface of the pressure actuator 58 from above and the pressure actuator 58 along the directional arrow 71 in the Fig. 17 transferred from the rest position to the connection position. In this shift the guide pin 65 rattling over the saw teeth in the groove bottom 67 of the guide grooves 66 to the end in the storage container 2 facing the end of the guide grooves 66. Now, the pressure actuator 58 by rotation according to the directional arrow 69 are turned off from the main body 61 of the transfer device 56, so that the pressure actuator can be removed from the body 61. Now, the use of container 3, so the standard syringe, via the Luer connector to the connecting portion 16 are connected. The remaining handling is, as in connection with the execution of the Fig. 1 to 12 described.
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Claims (6)
- Dispositif (56) destiné à transférer un liquide entre un récipient de stockage (2) et au moins un autre récipient d'utilisation (3), comprenant- une partie d'étanchéité de récipient de stockage (4) destinée à appliquer de manière étanche un corps de base (61) du dispositif de transfert (56) sur le récipient de stockage (2),- un ensemble à aiguille creuse (62) pourvu d'une aiguille creuse (63), l'ensemble à aiguille creuse (62) pouvant être déplacé par rapport au corps de base (61) linéairement le long d'un axe de déplacement (14) entre- - une position de repos rétractée et- - une position de liaison déployée dans laquelle l'aiguille creuse (63) crée un conduit de communication de fluide entre le récipient de stockage (2) et le dispositif de transfert (56),- une partie de liaison (16) destinée à relier de manière étanche le dispositif de transfert (56) au récipient d'utilisation (3),- un élément d'actionnement par pression (58) par lequel le déplacement de l'ensemble à aiguille creuse (62) peut être provoqué entre la position de repos et la position de liaison et qui est relié à l'aiguille creuse (63) en résistant au cisaillement pendant le déplacement,- un dispositif de guidage (64) destiné à guider axialement l'élément d'actionnement par pression (58) au niveau du corps de base (61) lors du déplacement de l'ensemble à aiguille creuse (62) de la position de repos à la position de liaison, le dispositif de guidage (64) comportant au moins un ergot de guidage (65) qui coulisse dans au moins une gorge de guidage associée (66) lors du déplacement de la position de repos à la position de liaison,- le dispositif de guidage (64) étant conçu de telle sorte que le déplacement de l'ensemble à aiguille creuse (62) de la position de repos à la position de liaison soit irréversible,caractérisé en ce que la gorge de guidage (66) se poursuit dans une bobine de guidage (68) qui permet une torsion de l'élément d'actionnement par pression (58) du corps de base (61).
- Dispositif selon la revendication 1, caractérisé en ce que l'au moins un ergot de guidage (65) est formé sur l'élément d'actionnement par pression (58).
- Dispositif selon la revendication 1 ou 2, caractérisé en ce qu'au moins une gorge de guidage (66) est formée dans le corps de base (61).
- Dispositif selon l'une des revendications 1 à 3, caractérisé en ce que la gorge de guidage (66) comporte une base de gorge (67) profilée en dent de scie.
- Dispositif selon l'une des revendications 1 à 4, caractérisé par un élément de fixation amovible (59) destiné à fixer l'élément d'actionnement par pression (58) en position de repos.
- Ensemble constitué d'un dispositif de transfert selon l'une des revendications 1 à 5 et d'un récipient de stockage (2).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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DE102015201275.1A DE102015201275A1 (de) | 2015-01-26 | 2015-01-26 | Vorrichtung zum Überführen einer Flüssigkeit zwischen einem Lagerbehälter und mindestens einem weiteren Gebrauchsbehälter |
PCT/EP2016/051320 WO2016120161A1 (fr) | 2015-01-26 | 2016-01-22 | Dispositif de transfert d'un liquide entre un récipient de stockage et au moins récipient d'utilisation |
Publications (2)
Publication Number | Publication Date |
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EP3250172A1 EP3250172A1 (fr) | 2017-12-06 |
EP3250172B1 true EP3250172B1 (fr) | 2019-03-06 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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EP16702677.2A Active EP3250172B1 (fr) | 2015-01-26 | 2016-01-22 | Dispositif de transfert d'un liquide entre un récipient de stockage et au moins récipient d'utilisation |
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Country | Link |
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US (1) | US20180014997A1 (fr) |
EP (1) | EP3250172B1 (fr) |
DE (1) | DE102015201275A1 (fr) |
DK (1) | DK3250172T3 (fr) |
ES (1) | ES2727729T3 (fr) |
WO (1) | WO2016120161A1 (fr) |
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USD935318S1 (en) | 2019-07-24 | 2021-11-09 | Aptar Radolfzell Gmbh | Spray head |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2738550B1 (fr) | 1995-09-11 | 1997-11-07 | Biodome | Dispositif d'obturation d'un recipient lui-meme ferme, ensemble pour dispenser un produit comprenant un tel recipient et un tel dispositif d'obturation |
GB9701413D0 (en) | 1997-01-24 | 1997-03-12 | Smithkline Beecham Biolog | Novel device |
US6209738B1 (en) | 1998-04-20 | 2001-04-03 | Becton, Dickinson And Company | Transfer set for vials and medical containers |
US7074216B2 (en) * | 1998-09-15 | 2006-07-11 | Baxter International Inc. | Sliding reconstitution device for a diluent container |
FR2783808B1 (fr) | 1998-09-24 | 2000-12-08 | Biodome | Dispositif de connexion entre un recipient et un contenant et ensemble pret a l'emploi comprenant un tel dispositif |
DE102004005435B3 (de) * | 2004-02-04 | 2005-09-15 | Haindl, Hans, Dr. | Medizinisches Transfergerät |
ES2570953T3 (es) * | 2006-05-25 | 2016-05-23 | Bayer Healthcare Llc | Procedimiento de montaje de un dispositivo de reconstitución |
EP2523708A4 (fr) | 2010-01-15 | 2015-02-25 | Bayer Healthcare Llc | Dispositif |
EP2959879B1 (fr) * | 2010-05-27 | 2017-03-01 | J&J Solutions, Inc. | Système de transfert de fluide fermé |
ES2593266T3 (es) | 2011-03-04 | 2016-12-07 | Duoject Medical Systems, Inc. | Sistema de transferencia de conexión fácil |
IL221635A0 (en) * | 2012-08-26 | 2012-12-31 | Medimop Medical Projects Ltd | Drug vial mixing and transfer device for use with iv bag and drug vial |
DE102012113002B4 (de) * | 2012-10-01 | 2014-04-30 | Medac Gesellschaft für klinische Spezialpräparate mbH | Transfervorrichtung zur Entnahme oder Übergabe eines Fluids |
RU2015143699A (ru) | 2013-03-14 | 2017-04-20 | Байер Хелскеа Ллк | Комплект для переливания |
IL225734A0 (en) * | 2013-04-14 | 2013-09-30 | Medimop Medical Projects Ltd | A ready-to-use medicine vial device including a medicine vial closure, and a medicine vial closure for it |
-
2015
- 2015-01-26 DE DE102015201275.1A patent/DE102015201275A1/de not_active Withdrawn
-
2016
- 2016-01-22 EP EP16702677.2A patent/EP3250172B1/fr active Active
- 2016-01-22 WO PCT/EP2016/051320 patent/WO2016120161A1/fr active Application Filing
- 2016-01-22 DK DK16702677.2T patent/DK3250172T3/da active
- 2016-01-22 ES ES16702677T patent/ES2727729T3/es active Active
- 2016-01-22 US US15/546,654 patent/US20180014997A1/en not_active Abandoned
Non-Patent Citations (1)
Title |
---|
None * |
Also Published As
Publication number | Publication date |
---|---|
DE102015201275A1 (de) | 2016-07-28 |
WO2016120161A1 (fr) | 2016-08-04 |
EP3250172A1 (fr) | 2017-12-06 |
US20180014997A1 (en) | 2018-01-18 |
DK3250172T3 (da) | 2019-06-11 |
ES2727729T3 (es) | 2019-10-18 |
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