EP3250172A1 - Device for transferring a fluid between a storage container and at least one further container for use - Google Patents
Device for transferring a fluid between a storage container and at least one further container for useInfo
- Publication number
- EP3250172A1 EP3250172A1 EP16702677.2A EP16702677A EP3250172A1 EP 3250172 A1 EP3250172 A1 EP 3250172A1 EP 16702677 A EP16702677 A EP 16702677A EP 3250172 A1 EP3250172 A1 EP 3250172A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- hollow needle
- transfer device
- storage container
- needle assembly
- container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2048—Connecting means
- A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1412—Containers with closing means, e.g. caps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2006—Piercing means
- A61J1/201—Piercing means having one piercing end
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2048—Connecting means
- A61J1/2055—Connecting means having gripping means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2079—Filtering means
- A61J1/2082—Filtering means for gas filtration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
Definitions
- the invention relates to a device for transferring a liquid between a storage container and at least one further use container. Furthermore, the invention relates to a set of such a transfer device and a storage container.
- Such devices are known from WO 2011/088471 AI, WO 2014/152249 AI, WO 98/32411 AI, US 6,209,738 B, US 6,537,263 Bl, US 5,879,345 and WO 2012 / 119225 AI.
- Such a device can be used in particular as a reconstitution device.
- a pulverulent medicament can then be present in the storage container, which initially mixes with the transfer device in the connection position via the then connected use container with a solvent and then via the transfer device into the same or another use container in dissolved form for further use is transferred.
- Irreversibility of the displacement, induced by the guide means, ensures that the transfer device can be used just once. An originality of the transfer device is thus guaranteed. This is particularly advantageous for a medical application of the transfer device.
- the guide pin can be integrally formed on a base body of the pressure actuator.
- the guide groove can be molded into the main body.
- a sawtooth-shaped profiled groove base gives the user a haptic and acoustic feedback of a displacement progress in the printing operation.
- the sawtooth profiling can ensure the irreversibility of the relocation.
- An embodiment of the guide groove with a guide coil according to claim 5 results in a controlled management of the pressure actuating element when releasing from the main body of the transfer device.
- a fuse element according to claim 6 prevents the pressure actuator is operated undesirable prior to the planned use.
- the advantages of a set according to claim 7 correspond to those in, the above reference to the transfer device according to the invention have already been explained.
- the set may also include at least one utility container, for example in the form of a standard syringe.
- FIG. 1 shows a perspective view of a device for transferring a liquid between a storage container and at least one further use container, shown in the assembled state before placing it on the storage container;
- Fig. 2 is an axial longitudinal section through the device of FIG. 1, shown in a on the
- FIG. 3 shows a representation of the transfer device similar to FIG. 2, in which some components have been omitted, furthermore illustrated with the hollow needle assembly in the rest position;
- Fig. 4 in a similar to Fig. 3 representation, the transfer device with the hollow needle assembly shortly after leaving the rest position in an intermediate position between the rest position and an extended connection position, wherein the hollow needle in the connection position a fluid connection channel between the storage container and the transfer device provides;
- Fig. 5 in a similar to Figures 3 and 4 representation, but with the lid of a rotary actuator, the transfer device in the connection position in which a removal of the rotary actuator is possible.
- Fig. 6 in a perspective view similar to Figure 1, the patch on the storage container transfer device with the hollow needle assembly in the connecting position after removal of the rotary actuator.
- FIG. 8a / b each in a similar to Fig. 7 representation enlarges a representation of flow paths on the one hand through a liquid channel for the transport of liquid through a hollow needle of the hollow needle assembly ( Figure 8a) and, on the other hand, a vent gas channel for transporting gas through the hollow needle assembly ( Figure 8b);
- Fig. 9 in perspective and increases a needle tip at the free end of the needle needle needle
- Hollow needle assembly wherein the one opening out there gas channel opening of the ventilation gas channel and one of two out there opening out liquid channel openings of the liquid channel is visible;
- FIG. 10 is a plan view of the needle tip, viewed from the viewing direction X in FIG. 9; FIG.
- FIG. 11a is a bottom view of a needle sleeve of the hollow needle assembly surrounding the hollow needle;
- FIG. 1b is a section along the line Xlb-XIb in FIG. 11a;
- FIG. 12 shows the needle sleeve, seen from the viewing direction of FIG. 11 opposite viewing direction, so that in addition a filter carrier of an air filter, not shown, is visible in the gas channel.
- FIG. 13 a / b show, in a representation similar to FIG. 8 b, an alternative embodiment of a hollow needle assembly with an additional ring in an area between the hollow needle and the
- Needle sleeve disposed axial channel body for extending an axial travel of the gas channel, wherein Fig. 13a shows an axial section and Fig. 13b shows an axial perspective view;
- FIG. 14 shows a representation similar to FIG. 1, but already placed on the storage container, another embodiment of a transfer device
- FIG. 15 shows the transfer device according to FIG. 14 after axial displacement of an outer sealing securing sleeve for securing a sealing abutment of a sealing section of the transfer device on the storage container;
- FIG. 17 shows an axial section through the transfer device according to FIG. 15;
- FIG. 18 shows, in a representation similar to FIG. 15, the transfer device according to FIGS. 14 et seq. After displacement of the hollow needle assembly into the extended connection position;
- FIG. 19 shows an axial section through the transfer device according to FIG. 18;
- FIG. Fig. 20a / b the transfer device of FIG. 14 ff.
- a pressure actuator of the transfer device to illustrate a guide means of the pressure-actuating element a body of the transfer device is shown broken;
- a first embodiment of a device 1 for transferring a liquid between a storage container 2 (see Fig. 6) and at least one further storage container 3 (see Fig. 6) will be described below with reference to Figs. All molded parts of the transfer device 1 are made of plastic and are designed in particular as injection-molded parts.
- the transfer device 1 has a sealing section 4 for the sealing abutment of a main body 5 (cf., Fig. 2) of the transfer device 1 on the storage container 2.
- the sealing section 4 rests against an elastomeric sealing plug of the storage container 2a, which will be described below ,
- the sealing portion 4 engages around a neck 6 of the storage container 2 (see Fig .. 5).
- An outer locking sleeve 7 of the transfer device 1 is used to secure the sealing portion 4 in its sealing position.
- Fig. 1 shows the securing sleeve 7 in a transport position of the transfer device 1 prior to placement on the storage container 2.
- Fig. 6 shows the securing sleeve 7 in a pushed over the sealing portion 4 securing position in the corresponding locking lug of the locking sleeve 7 in locking receptacles engage the sealing portion 4 and press it against the neck 6 of the storage container 2 sealing.
- the transfer device 1 further has a hollow needle assembly 9 with a hollow needle 10 and a surrounding needle sleeve 11.
- the hollow needle 10 is designed as a plastic hollow needle.
- the hollow needle 10 can also be designed, at least in sections, as a steel cannula. Through the hollow needle 10 there is a liquid transfer between the utility container 3 and the storage container 2 and at the same time a ventilation of these containers 2, 3, as will be explained in more detail below.
- the hollow needle assembly 9 is displaceable relative to the main body 5 linearly along a movement axis 13 (see Fig. 3) by means of a gear 12.
- This movement axis 13 extends coaxially to a central longitudinal axis 14 of the transfer device 1.
- a displacement of the hollow needle assembly 9 takes place between a, for example, in Figs. 2 and 3, retracted rest position and one example shown in FIG. 5, abandonedfah- connection position.
- the hollow needle 10 provides, inter alia, a fluid connection channel between the storage container 2 and the transfer device 1. This fluid channel extends between a free needle end 15 and an opposite connection section 16 (see Fig. 5).
- the connecting portion 16 is an integral part of the hollow needle 10.
- the connecting portion 16 is for sealing the connection of the transfer device 1 with the use of container 3 and is designed as a Luer connection. Accordingly, the use container 3 is designed as a standard syringe with a complementary Luer connection.
- the transfer device 1 can also be connected differently to the utility container 3, for example via another embodiment of a conical connection.
- the needle sleeve 11 is a separate component to the hollow needle 10.
- the needle sleeve 11 is peripherally sealed to the hollow needle 10 at two axial positions, namely on the one hand in the region of the connecting portion 16 facing the end of the needle sleeve 11 (see Fig. Connection area 17 in FIG .. 3 ) and on the other hand axially spaced at an opposite connecting portion 18. Between these connecting portions 17, 18 axially and between the hollow needle 10 and the needle sleeve 11 radially is an approximately hollow cylindrical annular space 19th
- the transfer device 1 further has a multi-part rotary actuator 20 which is connected via the gear 12 with the hollow needle assembly 9 in operative connection.
- the rotary actuator 20 has an annular cover 21 and an actuator base 22 (see, e.g., Figures 2 and 3).
- the rotary actuating element 20 is rotatable about the central longitudinal axis 14 relative to the main body 5 of the transfer device 1.
- the actuator body 22 is sealed against the body 5 of the transfer device 1 via a base seal 23 (see, e.g., Fig. 2). This creates a closed and in particular germ-tight space within the body.
- the rotary actuator 20 further includes an outer coupling sleeve 24 which is rotatably connected to the actuator base body 22 and can be understood as part of this body 22.
- the transmission 12 has an axially and about the central longitudinal axis 14 rotatably mounted in the main body 5 of the transfer device 1 Mit Meetingring 25 Radial is the drive ring 25 between the main body 5 and the needle sleeve 11.
- the driver ring 25 has an inner driver, the at the embodiment shown is designed as an internal thread 26.
- the internal thread 26 cooperates with a complementary thread 27, designed as an external thread, the needle sleeve 11 for displacing the hollow needle assembly 9 together.
- a complementary thread 27 designed as an external thread
- the actuating element base body 22 has a plurality, for example three, axial projections 28 (cf., for example, FIG. 3) which, as long as there is a non-rotatable connection of the actuating element base body 22 with the driving ring 25, into associated axial receptacles 29 of the driving ring 25 intervention.
- the axial nose 28 and the associated axial receptacles 29 are distributed in the circumferential direction about the central longitudinal axis 14.
- the axial lugs 28 are integral parts of the actuator base body 22nd
- the needle sleeve 11 Via inner axial ribs 30 (cf., for example, FIG. 4), which are embodied in the main body 5 of the transfer device 1, there is an anti-rotation of the hollow needle assembly 9 relative to the main body 5 about the central longitudinal axis 14.
- the needle sleeve 11 has axial guide grooves 31 complementary to the axial ribs 30 (see, for example, Figures Ia and 12).
- End faces 32 of these inner axial ribs 30 simultaneously represent an axial seat of the driving ring 25 in the main body 5 of the transfer device.
- the main body 5 of the transfer device 1 has a lift-off driver 33 designed as an external thread.
- the latter acts with a complementary internal thread.
- Fig. 4 shows by way of example the correspondingly relieved position in which the actuator base body 22 is lifted axially from the main body 5.
- the main body seal 23 may be designed as a silicone lamellar seal. Alternatively, the main body seal 23 may be designed as a hard / hard mechanical seal. In the connecting position (see Fig. 5), the drivers 33, 34 are disengaged, so that the entire rotary actuator 20 from the main body 5 of the transfer device 1 is removable.
- the transfer device 1 additionally has a locking device 35 for locking the hollow needle assembly 9 in the connecting position.
- This locking serves to ensure the originality of the transfer device 1, in that the displacement of the hollow needle assembly 9 into the connection position is made irreversible.
- the locking device 35 comprises a latching component 36 on the main body 5 of the transfer device 1, which cooperates with a detent counter-component 37 complementary thereto on the outer wall of the hollow needle 10 latching.
- Fig. 6 shows the transfer device 1 with the hollow needle assembly 9 in the connecting position with removed rotary actuator 20.
- the connecting portion 16 of the hollow needle assembly 9 is now accessible from above and no longer from the ring cover 21 of the rotary actuator 20th covered. Due to this accessibility of the connecting portion 16, this can be connected to the Luer connector of the utility container 3.
- the storage container 2 is sealed in the region of its neck 6 by a stopper 38 in the form of an elastomeric sealing plug or a sealing membrane.
- a stopper 38 in the form of an elastomeric sealing plug or a sealing membrane.
- Figs. 5, 7 and 8a / b can be seen that the hollow needle 10 has pierced the storage container 2, the sealing plug 38 of the storage container 2 in the connecting position.
- the liquid channel 39 already mentioned above in connection with the displacement of the hollow needle assembly 9 opens outward between the storage container 2 and the transfer device 1 via two liquid channel openings 40, 41 (see FIG out.
- the liquid channel 39 serves to transport liquid through the hollow needle 10.
- a ventilation gas channel 42 opens out of the hollow needle 10 via a gas channel opening 43.
- the ventilation gas duct 42 serves to transport gas through the hollow needle assembly 9, namely for venting or venting the storage container 2 or the use container 3.
- the channel paths of the liquid channel 39 on the one hand and the gas channel 42 on the other hand are separated from each other.
- the liquid channel 39 on the one hand and the gas channel 42 on the other hand open axially along the hollow needle 10 adjacent to each other and in the circumferential direction about the central longitudinal axis 14 offset from each other.
- Between each one of the liquid channel openings 40, 41 and the circumferentially adjacent gas channel opening 43 extends in the longitudinal direction of the hollow needle 10 extending needle-separating edge 44, 45.
- needle-separating edge 46 extends between The two needle-separating edges 44, 45 between the liquid channel openings 40, 41 and the gas channel opening 43 reduces undesired liquid transfer between the liquid channel 39 and the ventilation gas channel 42 the needle-separating edges 44 to 46 for reducing piercing forces of the hollow needle 12 in the sealing plug 38 of the storage container 2.
- the needle separating edges 44 to 46 have a cutting action when punctured in the sealing plug 38.
- the liquid channel openings 40, 41 are axially of the Needle tip at the free end of the needle 15 at least as far away as the gas channel opening 43. In the illustrated embodiment (see.
- the liquid channel openings 40, 41 are located axially further away from the needle tip at the free needle end 15 than the gas channel opening 43.
- a gas flow path through the ventilation gas channel 42 initially runs via a gas channel section 47, which runs parallel to the central longitudinal axis 14 in the hollow needle 10.
- the gas channel section 47 discharges via an opening 48 (see Fig. 8a / b) into the annular space 19 between the hollow needle 10 and the needle sleeve 11.
- the annular space 19 thus forms a portion of the ventilation gas channel 42.
- the needle sleeve 11 has a plurality of needle sleeve passage openings 49. In total, eight such needle sleeve passage openings 49 are arranged distributed around the central longitudinal axis 14 around the same.
- the needle sleeve passage openings 49 provide a flow passage of the ventilation gas channel 42 between the annular space 19 and a further annular space 50 in a bottom-side, ie the storage container 2 facing, portion of the needle sleeve 11.
- this further annular space 50 is an annular disk-shaped Filter carrier 51 is arranged, which surrounds the hollow needle 10 annular.
- the filter support 51 carries a likewise annular air filter 52 of the transfer device 1.
- the transfer device 1 is used as follows:
- the transfer device 1 in the configuration according to FIG. 1 is placed on the neck 6 of the storage container 2 in which there is, for example, a powdered medicament. Subsequently, the seal securing sleeve 7 is pushed over the sealing portion 4. As a result, the transfer device 1 is secured on the neck 6 of the storage container 2, wherein in particular a tamper-evident closure can be ensured.
- this sealing section 4 is secured by the sliding of the sealing safety sleeve 7 via the sealing section 4 and the transfer device 1 seals against the storage container 2.
- the rotary actuator 20 is rotated in the direction indicated by arrow symbols 53 on the outside of the ring cover 21 direction of rotation by 360 ° or an even larger angle of rotation.
- the driving ring 25 which, axially mounted in the base body 5, now also rotates about the central longitudinal axis 14, thereby axially displaced against the base body 5 but not. Axially the driving ring 25 is secured over undercuts in the base body 5.
- the threads 26, 27 now begins the displacement of the hollow needle assembly 9 relative to the base body 5 in the direction of the movement axis 13, ie to the storage container 2 to.
- the hollow needle assembly 9 Upon further rotation of the rotary actuator 20, the hollow needle assembly 9 is displaced in the connecting position shown in FIG. 5 and pierces the plug 38 of the storage container 2. This happens, on the one hand the thread 26, 27 and on the other hand, the thread 33, 34 disengaged with each other. In the connecting position, the locking device 35 is engaged and the hollow needle assembly 9 is irreversibly secured in this position.
- the entire rotary actuator 20 can be removed and the use of container 3, so the standard injection syringe can be connected via the Luer coupling with the connecting portion 16 of the transfer device 1.
- container 3 is a matched to the drug in the storage container 2 solvent.
- this solvent is injected by actuation of a syringe plunger of the use container 3 via the transfer device 1 into the interior of the storage container 2.
- the solvent flows through the liquid channel 39 in the hollow needle 10 and exits via the two liquid channel openings 40, 41 from the hollow needle 10 into the storage container 2.
- the arrangement of the liquid channel openings 40, 41 relative to the gas channel opening 43 reduces an overflow of liquid droplets into the gas channel during injection, since the liquid does not flow in the direction of gravity downwards and thus during injection in the direction of the gas channel.
- air escapes from the storage container 2 via the gas channel opening 43 through the ventilation gas channel 42 via the gas channel section 47, the passage opening 48, the annular space 19, the needle sleeve passage openings 49, the annular space 50 , the air filter 52 and from there between the needle sleeve 11 and the main body 5 of the transfer device 1 to the outside.
- a solution of the initially powdered medicament in the solvent is brought about by shaking the assembly from the storage container 2, the transfer device 1 and the use container 3.
- the dissolved medicament flows via the liquid channel 39 through the hollow needle 10 to the storage container 2 into the use container 3.
- This flow of the dissolved medicament into the use container 3 is produced by mounting the use container 3 designed as a syringe. Transferring the dissolved medicament from the storage container 2 into - Lü the utility container 3 is usually in over-head position, in which the storage container 2 is disposed above the utility container 3.
- the liquid channel openings 40, 41 are closer to a residual solution of the dissolved drug, so that a residual emptying of the solution is improved.
- the gas channel opening 43 is farther from the solution residue than the liquid channel openings 40, 41, so that the gas channel can fulfill its ventilation function well.
- the inflowing air is sterile-filtered by the air filter 52.
- FIGS. 13 a and 13 b show a variant of a hollow needle assembly 54 that can be used instead of the hollow needle assembly 9 in the transfer device 1.
- Components and functions which correspond to those already explained above with reference to the embodiment according to FIGS. 1 to 12 bear the same reference numerals and designations and will not be discussed again in detail.
- an axial channel body 55 is arranged in the annular space 19. This is carried out so that a reversal of the direction of the ventilation gas duct 42 does not take place, as in the embodiment of FIGS. 1 to 12, in the bottom, the storage container 2 facing region of the annular space 19, but approximately at an axial height A of about two One third of the total axial height of the annulus 19.
- the axial channel body 55 Prior to the direction reversal channel section, the axial channel body 55 causes a corresponding extension of an axial travel of the vent gas channel 42.
- the axial channel body 55 effectively suppresses unwanted entrainment of liquid along the entire ventilation gas channel 42.
- the path of the gas through the gas channel 42 during venting of the storage container 2 is indicated in Fig. 13a by a directional arrow 55a.
- the axial channel body 55 is designed as up to a height of two-thirds of the entire axial height of the annular space 19 sealed sub-segment between the hollow needle 10 and the needle sleeve 11.
- the passage openings 48 are closed so that an ascent of the air flowing out of the storage container 2 is forced upon injection of the liquid into the storage container 2. The air then flows after the rise and the direction reversal through the remaining openings 48 of the unlocked segment.
- inflowing liquid droplets are additionally distributed or deposited by gravity.
- a further embodiment of a transfer device 56 which can be used instead of the transfer device 1 according to FIGS.
- FIG. 14 shows the transfer device 56 after it has been placed on the storage container 2 and before the seal securing sleeve 7 has been displaced.
- Fig. 15 shows the transfer device 56 after shifting the seal retainer sleeve 7 to the securing position for the sealing portion 4.
- Fig. 16 shows the transfer device 56 in a transport configuration. In this transport configuration is displaced in the securing position seal-securing sleeve 7 between this and a head portion 57 of a pressure-actuating element 58 of the transfer device 56 a removable securing element 59 introduced in the form of a locking half-ring. The securing element 59 is inserted into a circumferential receiving groove 60 (cf., FIG. 15) of the head section 57 of the pressure actuating element 58.
- the securing element 59 prevents a displacement of the pressure actuating element 58 relative to a base body 61 (see Fig. 17) of the transfer device 56 in the direction of the storage container 2. An unintentional pressure actuation of the pressure actuating element 58 is thus prevented.
- the hollow needle assembly 62 apart from an external geometry of the needle sleeve 11 constructed as the hollow needle assembly 9.
- the design of the hollow needle assembly 62 with respect to the liquid channel and the ventilation gas channel is as already explained with reference to the hollow needle assembly 9 in connection with FIGS. 1 to 12.
- Hollow needle assembly 62 from the rest position to the connecting position is a guide device 64.
- the latter has two guide pins 65 which are integrally formed on an inner side of a jacket wall of the pressure-actuating element 58.
- the guide pins 65 slide during the relocation from the rest position into the connecting position in each case in an associated guide groove 66 which is executed in an outer wall of the base body 61 of the transfer device 56.
- the guide device 64 is designed such that the displacement of the hollow needle assembly 62 from the rest position to the connecting position is irreversible.
- the two guide grooves 66 each have a sawtooth-shaped profiled groove bottom 67, which is shown in FIG. 19 in cross-section and in FIG. 20a / b for one of the two guide grooves 66 in a perspective view.
- the profiling of saw teeth in groove base 67 is such that the guide pin 65 can slide on the displacement of the pressure actuating element 58 from the rest position into the connecting position on inclined surfaces of the saw teeth. In the connecting position, a sliding back of the guide pin 65 in the guide grooves 66 upwards is not possible, since the guide pins 65 are then blocked by vertical surfaces of the sawtooth profiling.
- the guide grooves 66 each continue into a guide helix 68.
- a turning of the pressure actuating element 58 from the base body 61 of the transfer device 56 is possible via this guide helix 68, as indicated by directional arrows 69, 70 in FIG. 20 a / b.
- the guide pins 65 of the pressure-actuating element 58 slide in each case in one of the two guide spirals 68 on the outside of the main body 61 of the transfer device 56 until the guide pin 65 at the end of the guide spirals 68 out of engagement with the main body 61.
- the transfer device 56 After removal of the pressure actuator 58, the transfer device 56 is in the momentary engagement shown in FIG. In this instantaneous position, the connecting section 16 of the hollow needle 63 is accessible from above, as has already been explained in connection with the transfer device 1 and FIG. 6.
- the transfer device 56 is used as follows:
- the transfer device 56 is located together with the storage container 2, in which the pul deformed drug is held, first in the transport position shown in FIG. 16 with inserted securing element 59 before.
- the securing element 59 When using the transfer device 56, the securing element 59 is first withdrawn. Then, pressure is applied to an upper end surface of the pressure operation member 58 from above and the pressure operation member 58 is transferred along the directional arrow 71 in FIG. 17 from the rest position to the connection position. In this shift, the guide pins rattle 65 on the saw teeth in the groove bases 67 of the guide grooves 66 to the end in the storage container 2 end of the guide grooves 66. Now, the pressure actuator 58 by rotation according to the tion arrow 69 are turned off from the main body 61 of the transfer device 56, so that the pressure actuator can be removed from the body 61. Now, the use of container 3, so the standard syringe, via the Luer connector to the connecting portion 16 are connected. The remaining handling is as described in connection with the embodiment according to FIGS. 1 to 12.
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102015201275.1A DE102015201275A1 (en) | 2015-01-26 | 2015-01-26 | Device for transferring a liquid between a storage container and at least one further use container |
PCT/EP2016/051320 WO2016120161A1 (en) | 2015-01-26 | 2016-01-22 | Device for transferring a fluid between a storage container and at least one further container for use |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3250172A1 true EP3250172A1 (en) | 2017-12-06 |
EP3250172B1 EP3250172B1 (en) | 2019-03-06 |
Family
ID=55299434
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP16702677.2A Active EP3250172B1 (en) | 2015-01-26 | 2016-01-22 | Device for transferring a fluid between a storage container and at least one further container for use |
Country Status (6)
Country | Link |
---|---|
US (1) | US20180014997A1 (en) |
EP (1) | EP3250172B1 (en) |
DE (1) | DE102015201275A1 (en) |
DK (1) | DK3250172T3 (en) |
ES (1) | ES2727729T3 (en) |
WO (1) | WO2016120161A1 (en) |
Families Citing this family (1)
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USD935318S1 (en) * | 2019-07-24 | 2021-11-09 | Aptar Radolfzell Gmbh | Spray head |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2738550B1 (en) | 1995-09-11 | 1997-11-07 | Biodome | DEVICE FOR SEALING A CONTAINER ITSELF CLOSED, ASSEMBLY FOR PROVIDING A PRODUCT COMPRISING SUCH A CONTAINER AND SUCH A SEALING DEVICE |
GB9701413D0 (en) | 1997-01-24 | 1997-03-12 | Smithkline Beecham Biolog | Novel device |
US6209738B1 (en) | 1998-04-20 | 2001-04-03 | Becton, Dickinson And Company | Transfer set for vials and medical containers |
US7074216B2 (en) * | 1998-09-15 | 2006-07-11 | Baxter International Inc. | Sliding reconstitution device for a diluent container |
FR2783808B1 (en) | 1998-09-24 | 2000-12-08 | Biodome | CONNECTION DEVICE BETWEEN A CONTAINER AND A CONTAINER AND READY-TO-USE ASSEMBLY COMPRISING SUCH A DEVICE |
DE102004005435B3 (en) * | 2004-02-04 | 2005-09-15 | Haindl, Hans, Dr. | Medical transfer device |
JP4897879B2 (en) * | 2006-05-25 | 2012-03-14 | バイエル・ヘルスケア・エルエルシー | Reconfiguration device |
CN102869397B (en) | 2010-01-15 | 2015-10-14 | 拜耳医药保健有限公司 | Device |
NZ726167A (en) * | 2010-05-27 | 2018-06-29 | J&J Solutions Inc | Closed fluid transfer system |
CA2827993C (en) | 2011-03-04 | 2018-04-17 | Duoject Medical Systems Inc. | Easy linking transfer system |
IL221635A0 (en) * | 2012-08-26 | 2012-12-31 | Medimop Medical Projects Ltd | Drug vial mixing and transfer device for use with iv bag and drug vial |
DE102012113002B4 (en) * | 2012-10-01 | 2014-04-30 | Medac Gesellschaft für klinische Spezialpräparate mbH | Transfer device for removing or transferring a fluid |
CA2905955A1 (en) | 2013-03-14 | 2014-09-25 | Bayer Healthcare Llc | Transfer set |
IL225734A0 (en) * | 2013-04-14 | 2013-09-30 | Medimop Medical Projects Ltd | Ready-to-use drug vial assemblages including drug vial and drug vial closure having fluid transfer member, and drug vial closure therefor |
-
2015
- 2015-01-26 DE DE102015201275.1A patent/DE102015201275A1/en not_active Withdrawn
-
2016
- 2016-01-22 EP EP16702677.2A patent/EP3250172B1/en active Active
- 2016-01-22 DK DK16702677.2T patent/DK3250172T3/en active
- 2016-01-22 US US15/546,654 patent/US20180014997A1/en not_active Abandoned
- 2016-01-22 WO PCT/EP2016/051320 patent/WO2016120161A1/en active Application Filing
- 2016-01-22 ES ES16702677T patent/ES2727729T3/en active Active
Also Published As
Publication number | Publication date |
---|---|
DE102015201275A1 (en) | 2016-07-28 |
DK3250172T3 (en) | 2019-06-11 |
ES2727729T3 (en) | 2019-10-18 |
EP3250172B1 (en) | 2019-03-06 |
US20180014997A1 (en) | 2018-01-18 |
WO2016120161A1 (en) | 2016-08-04 |
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