EP3146060A4 - Procédés de production d'huile dans des micro-organismes - Google Patents

Procédés de production d'huile dans des micro-organismes Download PDF

Info

Publication number
EP3146060A4
EP3146060A4 EP15795730.9A EP15795730A EP3146060A4 EP 3146060 A4 EP3146060 A4 EP 3146060A4 EP 15795730 A EP15795730 A EP 15795730A EP 3146060 A4 EP3146060 A4 EP 3146060A4
Authority
EP
European Patent Office
Prior art keywords
microorganisms
methods
oil production
oil
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP15795730.9A
Other languages
German (de)
English (en)
Other versions
EP3146060B1 (fr
EP3146060A2 (fr
Inventor
Zhiyong Sun
Roberto E. ARMENTA
Mercia VALENTINE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mara Renewables Corp
Original Assignee
Mara Renewables Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mara Renewables Corp filed Critical Mara Renewables Corp
Publication of EP3146060A2 publication Critical patent/EP3146060A2/fr
Publication of EP3146060A4 publication Critical patent/EP3146060A4/fr
Application granted granted Critical
Publication of EP3146060B1 publication Critical patent/EP3146060B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/64Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409Fatty acids
    • C12P7/6427Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6434Docosahexenoic acids [DHA]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/64Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409Fatty acids
    • C12P7/6427Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/64Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436Fatty acid esters
    • C12P7/6445Glycerides
    • C12P7/6463Glycerides obtained from glyceride producing microorganisms, e.g. single cell oil
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/64Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436Fatty acid esters
    • C12P7/6445Glycerides
    • C12P7/6472Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
EP15795730.9A 2014-05-22 2015-05-21 Procédés de production d'huile dans des micro-organismes Active EP3146060B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462001912P 2014-05-22 2014-05-22
PCT/IB2015/001407 WO2015177641A2 (fr) 2014-05-22 2015-05-21 Procédés de production d'huile dans des micro-organismes

Publications (3)

Publication Number Publication Date
EP3146060A2 EP3146060A2 (fr) 2017-03-29
EP3146060A4 true EP3146060A4 (fr) 2017-12-20
EP3146060B1 EP3146060B1 (fr) 2019-12-18

Family

ID=54554909

Family Applications (1)

Application Number Title Priority Date Filing Date
EP15795730.9A Active EP3146060B1 (fr) 2014-05-22 2015-05-21 Procédés de production d'huile dans des micro-organismes

Country Status (12)

Country Link
US (2) US20150337345A1 (fr)
EP (1) EP3146060B1 (fr)
KR (1) KR102236782B1 (fr)
CN (1) CN106795539B (fr)
AU (1) AU2015263044B2 (fr)
BR (1) BR112017002791B1 (fr)
CA (2) CA3159974A1 (fr)
DK (1) DK3146060T3 (fr)
ES (1) ES2774452T3 (fr)
IL (1) IL249638A0 (fr)
PT (1) PT3146060T (fr)
WO (1) WO2015177641A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3146060B1 (fr) 2014-05-22 2019-12-18 Mara Renewables Corporation Procédés de production d'huile dans des micro-organismes
US10851395B2 (en) * 2016-06-10 2020-12-01 MARA Renewables Corporation Method of making lipids with improved cold flow properties
MX2021004051A (es) * 2018-11-02 2021-06-04 Mara Renewables Corp Aceite de algas con valor nutricional mejorado.
CN112391292A (zh) * 2020-11-23 2021-02-23 江南大学 一种中链脂肪酸碳链延长功能微生物及其富集方法和应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005021735A1 (fr) * 2003-09-01 2005-03-10 Novozymes A/S Procede d'augmentation du rendement de biomasse et/ou de constituants de biomasse a partir de micro-organismes marins
WO2005045050A1 (fr) * 2003-11-10 2005-05-19 Nutrinova Nutrition Specialties & Food Ingredients Gmbh Procede pour cultiver des micro-organismes de l'ordre des thraustochytriales
US20120244584A1 (en) * 2011-03-07 2012-09-27 Ocean Nutrition Canada Limited Engineering microorganisms
WO2014141098A1 (fr) * 2013-03-13 2014-09-18 Dsm Nutritional Products Ag Modification génétique de micro-organismes

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5340742A (en) 1988-09-07 1994-08-23 Omegatech Inc. Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids
US5340594A (en) 1988-09-07 1994-08-23 Omegatech Inc. Food product having high concentrations of omega-3 highly unsaturated fatty acids
KR20090064603A (ko) 2000-01-28 2009-06-19 마텍 바이오싸이언스스 코포레이션 발효기 내에서 진핵 미생물의 고밀도 배양에 의한 고도불포화 지방산을 함유하는 지질의 증진된 생산 방법
EP1359224A1 (fr) * 2002-05-01 2003-11-05 Ato B.V. Procédé de production d'acides gras polyinsaturés par des microorganismes marins
CN103834699A (zh) 2003-10-02 2014-06-04 Dsmip资产公司 使用改进量的氯和钾在微藻类中产生高水平的dha
DE10352838A1 (de) * 2003-11-10 2005-07-07 Nutrinova Nutrition Specialties & Food Ingredients Gmbh Verfahren zur Kultivierung von Mikroorganismen der Gattung Thraustochytriales unter Verwendung eines optimierten Niedrigsalzmediums
ES2576986T3 (es) 2005-06-07 2016-07-12 Dsm Nutritional Products Ag Microorganismos eucariotas para la producción de lípidos y antioxidantes
ZA200800079B (en) * 2005-06-07 2009-03-25 Ocean Nutrition Canada Ltd Eukaryotic microorganisms for producing lipids and antioxidants
EP2194138A1 (fr) * 2008-12-08 2010-06-09 Marenutrica GmbH Composés contenant de l'acide docosahexaénoïque et son procédé de production
US20120202242A1 (en) 2011-02-09 2012-08-09 Hazlebeck David A System and Method for Non-Sterile Heterotrophic Algae Growth
EP3146060B1 (fr) 2014-05-22 2019-12-18 Mara Renewables Corporation Procédés de production d'huile dans des micro-organismes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005021735A1 (fr) * 2003-09-01 2005-03-10 Novozymes A/S Procede d'augmentation du rendement de biomasse et/ou de constituants de biomasse a partir de micro-organismes marins
WO2005045050A1 (fr) * 2003-11-10 2005-05-19 Nutrinova Nutrition Specialties & Food Ingredients Gmbh Procede pour cultiver des micro-organismes de l'ordre des thraustochytriales
US20120244584A1 (en) * 2011-03-07 2012-09-27 Ocean Nutrition Canada Limited Engineering microorganisms
WO2014141098A1 (fr) * 2013-03-13 2014-09-18 Dsm Nutritional Products Ag Modification génétique de micro-organismes

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ADAM M BURJA ET AL: "Isolation and characterization of polyunsaturated fatty acid producing Thraustochytrium species: screening of strains and optimization of omega-3 production", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER, BERLIN, DE, vol. 72, no. 6, 20 April 2006 (2006-04-20), pages 1161 - 1169, XP019441696, ISSN: 1432-0614, DOI: 10.1007/S00253-006-0419-1 *
See also references of WO2015177641A2 *

Also Published As

Publication number Publication date
EP3146060B1 (fr) 2019-12-18
CN106795539A (zh) 2017-05-31
BR112017002791A2 (pt) 2023-02-07
ES2774452T3 (es) 2020-07-21
CN106795539B (zh) 2021-06-22
PT3146060T (pt) 2020-02-19
KR102236782B1 (ko) 2021-04-05
KR20170020373A (ko) 2017-02-22
EP3146060A2 (fr) 2017-03-29
DK3146060T3 (da) 2020-02-10
AU2015263044A1 (en) 2017-01-12
CA2953060C (fr) 2022-09-20
BR112017002791B1 (pt) 2024-03-05
IL249638A0 (en) 2017-03-30
WO2015177641A2 (fr) 2015-11-26
CA3159974A1 (fr) 2015-11-26
CA2953060A1 (fr) 2015-11-26
US11466297B2 (en) 2022-10-11
AU2015263044B2 (en) 2021-07-01
WO2015177641A3 (fr) 2016-01-21
US20210363554A1 (en) 2021-11-25
US20150337345A1 (en) 2015-11-26

Similar Documents

Publication Publication Date Title
EP3143651A4 (fr) Condensateur et son procédé de production
EP3159164A4 (fr) Stratifié et son procédé de production
EP3149152A4 (fr) Augmentation de la production de lipides et optimisation de la composition lipidique
EP3176245A4 (fr) Composition lubrifiante et procédé de production de composition lubrifiante
EP3161166A4 (fr) Compositions et procédés pour la production rapide de répertoires polyvalents de nanocorps
EP3094817A4 (fr) Système et procédé de production de pétrole
EP3167066A4 (fr) Microorganismes et procédés de production de butadiène par l'utilisation d'acétyl-coa
EP3099493A4 (fr) Barres d'impression et procédés de formation de barres d'impression
EP3374490A4 (fr) Expression hétérologue de la taurine dans des micro-organismes
EP3173226A4 (fr) Stratifié et procédé de production pour celui-ci
EP3225595A4 (fr) Procédé de production d'eau
EP3164495A4 (fr) Micro-organismes pour la production de composés en 4c-5 c avec une insaturation et procédés associés
EP3138558A4 (fr) Composition liposomale et procédé de production associé
TWI560140B (en) Method of making nanostructure
IL249638A0 (en) Methods for oil production in microorganisms
EP3218354A4 (fr) Nouveaux procédés
EP3147369A4 (fr) Procédé de production de protéines de type fibroïne
EP3138555A4 (fr) Composition liposomale et procédé de production associé
GB201612282D0 (en) Process and composition for producing oil
GB201417268D0 (en) Modified microorganisms and methods for production of useful products
EP3180296A4 (fr) Procédés de production d'alkylfuranes
EP3240870A4 (fr) Procédé de thermolyse de biomasse en présence de sulfure d'hydrogène
EP3214139A4 (fr) Procédé de production de composé azoïque
EP3143106A4 (fr) Lubrifiants à base de monoesters et procédés de production desdits lubrifiants
EP3215632A4 (fr) Procédé amélioré pour la détermination de micro-organismes

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20161220

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

RIN1 Information on inventor provided before grant (corrected)

Inventor name: ARMENTA, ROBERTO, E.

Inventor name: VALENTINE, MERCIA

Inventor name: SUN, ZHIYONG

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20171117

RIC1 Information provided on ipc code assigned before grant

Ipc: C12N 1/00 20060101ALI20171113BHEP

Ipc: C12P 7/40 20060101ALI20171113BHEP

Ipc: C12N 1/10 20060101ALI20171113BHEP

Ipc: C12P 7/64 20060101AFI20171113BHEP

REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1234784

Country of ref document: HK

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

INTG Intention to grant announced

Effective date: 20190708

GRAJ Information related to disapproval of communication of intention to grant by the applicant or resumption of examination proceedings by the epo deleted

Free format text: ORIGINAL CODE: EPIDOSDIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

GRAR Information related to intention to grant a patent recorded

Free format text: ORIGINAL CODE: EPIDOSNIGR71

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE PATENT HAS BEEN GRANTED

INTC Intention to grant announced (deleted)
AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

INTG Intention to grant announced

Effective date: 20191108

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602015043975

Country of ref document: DE

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 1214635

Country of ref document: AT

Kind code of ref document: T

Effective date: 20200115

REG Reference to a national code

Ref country code: DK

Ref legal event code: T3

Effective date: 20200207

REG Reference to a national code

Ref country code: CH

Ref legal event code: NV

Representative=s name: VALIPAT S.A. C/O BOVARD SA NEUCHATEL, CH

REG Reference to a national code

Ref country code: FI

Ref legal event code: FGE

REG Reference to a national code

Ref country code: PT

Ref legal event code: SC4A

Ref document number: 3146060

Country of ref document: PT

Date of ref document: 20200219

Kind code of ref document: T

Free format text: AVAILABILITY OF NATIONAL TRANSLATION

Effective date: 20200206

REG Reference to a national code

Ref country code: SE

Ref legal event code: TRGR

REG Reference to a national code

Ref country code: NL

Ref legal event code: FP

REG Reference to a national code

Ref country code: NO

Ref legal event code: T2

Effective date: 20191218

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191218

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20200318

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191218

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20200319

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191218

Ref country code: RS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191218

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191218

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2774452

Country of ref document: ES

Kind code of ref document: T3

Effective date: 20200721

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191218

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191218

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191218

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20200418

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191218

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191218

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602015043975

Country of ref document: DE

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20200921

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191218

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191218

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191218

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200521

REG Reference to a national code

Ref country code: AT

Ref legal event code: MM01

Ref document number: 1214635

Country of ref document: AT

Kind code of ref document: T

Effective date: 20200521

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200521

REG Reference to a national code

Ref country code: AT

Ref legal event code: UEP

Ref document number: 1214635

Country of ref document: AT

Kind code of ref document: T

Effective date: 20191218

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191218

Ref country code: MT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191218

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191218

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191218

P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20230425

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: PT

Payment date: 20230522

Year of fee payment: 9

Ref country code: NO

Payment date: 20230510

Year of fee payment: 9

Ref country code: IT

Payment date: 20230427

Year of fee payment: 9

Ref country code: IE

Payment date: 20230425

Year of fee payment: 9

Ref country code: FR

Payment date: 20230421

Year of fee payment: 9

Ref country code: ES

Payment date: 20230602

Year of fee payment: 9

Ref country code: DK

Payment date: 20230511

Year of fee payment: 9

Ref country code: DE

Payment date: 20230418

Year of fee payment: 9

Ref country code: CH

Payment date: 20230602

Year of fee payment: 9

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: SE

Payment date: 20230426

Year of fee payment: 9

Ref country code: FI

Payment date: 20230513

Year of fee payment: 9

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 20230427

Year of fee payment: 9

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20230420

Year of fee payment: 9

REG Reference to a national code

Ref country code: DE

Ref legal event code: R082

Ref document number: 602015043975

Country of ref document: DE

Representative=s name: FORRESTERS IP LLP, DE

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 20240426

Year of fee payment: 10