EP3129002A4 - Composition et procédé de production d'une nanoformulation de composés bioactifs insolubles dans l'eau dans un support aqueux - Google Patents

Composition et procédé de production d'une nanoformulation de composés bioactifs insolubles dans l'eau dans un support aqueux Download PDF

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Publication number
EP3129002A4
EP3129002A4 EP15777362.3A EP15777362A EP3129002A4 EP 3129002 A4 EP3129002 A4 EP 3129002A4 EP 15777362 A EP15777362 A EP 15777362A EP 3129002 A4 EP3129002 A4 EP 3129002A4
Authority
EP
European Patent Office
Prior art keywords
nanoformulation
bioactives
producing
composition
water insoluble
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP15777362.3A
Other languages
German (de)
English (en)
Other versions
EP3129002A2 (fr
Inventor
Rambhau Devraj
Pranati CHHATOI
Naga Hemanth Kumar PARVATHABHATLA
Anand Vasant DESHMUKH
Krishna Kaushik CHINTABHATLA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PULSE PHARMACEUTICALS PVT. LTD.
Original Assignee
Nanoceutica Laboratories Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanoceutica Laboratories Pvt Ltd filed Critical Nanoceutica Laboratories Pvt Ltd
Publication of EP3129002A2 publication Critical patent/EP3129002A2/fr
Publication of EP3129002A4 publication Critical patent/EP3129002A4/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Colloid Chemistry (AREA)
EP15777362.3A 2014-04-09 2015-04-08 Composition et procédé de production d'une nanoformulation de composés bioactifs insolubles dans l'eau dans un support aqueux Pending EP3129002A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1872CH2014 IN2014CH01872A (fr) 2014-04-09 2015-04-08
PCT/IB2015/052541 WO2015155703A2 (fr) 2014-04-09 2015-04-08 Composition et procédé de production d'une nanoformulation de composés bioactifs insolubles dans l'eau dans un support aqueux

Publications (2)

Publication Number Publication Date
EP3129002A2 EP3129002A2 (fr) 2017-02-15
EP3129002A4 true EP3129002A4 (fr) 2017-11-08

Family

ID=54288490

Family Applications (1)

Application Number Title Priority Date Filing Date
EP15777362.3A Pending EP3129002A4 (fr) 2014-04-09 2015-04-08 Composition et procédé de production d'une nanoformulation de composés bioactifs insolubles dans l'eau dans un support aqueux

Country Status (7)

Country Link
US (1) US11458096B2 (fr)
EP (1) EP3129002A4 (fr)
AU (1) AU2015246030B2 (fr)
EA (1) EA038458B1 (fr)
IN (1) IN2014CH01872A (fr)
MX (1) MX2016013201A (fr)
WO (1) WO2015155703A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2947390C (fr) 2014-04-30 2022-10-18 Matoke Holdings Limited Compositions antimicrobiennes
GB201716986D0 (en) 2017-10-16 2017-11-29 Matoke Holdings Ltd Antimicrobial compositions
FR3075661A1 (fr) 2017-12-21 2019-06-28 Coatex Emulsion submicronique
WO2019175830A1 (fr) * 2018-03-14 2019-09-19 Azista Industries Pvt Ltd Formulations de nano-émulsions de cholécalciférol, et procédés d'utilisation correspondants
WO2023118928A1 (fr) 2021-12-21 2023-06-29 Opella Healthcare Group Sas Nanoformulation stable pour principes actifs lipophiles, forme de dosage orale et son procédé de préparation

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997010814A1 (fr) * 1995-09-18 1997-03-27 Vesifact Ag Nanodispersions de propofol
WO2003077882A2 (fr) * 2002-03-18 2003-09-25 Labopharm Inc. Preparation de nanodispersions stabilisees steriles
WO2010146606A1 (fr) * 2009-06-19 2010-12-23 Sun Pharma Advanced Research Company Ltd., Nanodispersion d'un médicament et son procédé de préparation
US20110229554A1 (en) * 2010-03-12 2011-09-22 Niven Rajin Narain INTRAVENOUS FORMULATIONS OF COENZYME Q10 (CoQ10) AND METHODS OF USE THEREOF
EP2387991A1 (fr) * 2006-02-01 2011-11-23 Adventrx Pharmaceuticals, Inc. Compositions pharmaceutiques stabilisées à succinate de vitamine E, procédés de préparation et utilisation associée

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WO1992018147A1 (fr) * 1991-04-19 1992-10-29 Affinity Biotech, Inc. Formulations de microemulsions a inversion de phase
CA2091152C (fr) 1993-03-05 2005-05-03 Kirsten Westesen Particules lipidiques solides, particules d'agents bioactifs, et methode de preparation et d'utilisation
US5518738A (en) 1995-02-09 1996-05-21 Nanosystem L.L.C. Nanoparticulate nsaid compositions
DE19642359A1 (de) 1996-10-14 1998-04-16 Basf Ag Stabile Emulsionen und Trockenpulver von Mischungen fettlöslicher Vitamine, deren Herstellung und Verwendung
US5994414A (en) 1997-04-28 1999-11-30 Avon Products, Inc. Water-thin emulsion formed by high pressure homogenization process
ES2210056T3 (es) * 2001-04-12 2004-07-01 Vesifact Ag Preconcentrados en microemulsion y microemulsiones que contienen coenzima q10.
CA2486553C (fr) 2002-06-17 2012-01-10 Taro Pharmaceuticals U.S.A., Inc. Suspension d'ibuprofene
US8628690B2 (en) 2004-02-23 2014-01-14 The Texas A&M University System Nanoemulsion compositions and methods of use thereof
EP1597973A1 (fr) 2004-05-18 2005-11-23 Nestec S.A. Emulsion d'huile dans l'eau pour livraison
US20060051462A1 (en) * 2004-09-03 2006-03-09 Wang Jimmy X Self emulsifying compositions for delivering lipophilic coenzyme Q10 and other dietary ingredients
DK3144013T3 (en) 2005-12-01 2019-03-04 Univ Massachusetts Lowell Botulinum nanoemulsions
EP2001439A2 (fr) 2006-03-07 2008-12-17 Novavax, Inc. Emulsions nano-structurees des agents actifs mauvais soluble et leurs procedes de fabrication
EP1938801A1 (fr) 2006-12-22 2008-07-02 Biofrontera Bioscience GmbH Nanoémulsion
WO2009067734A1 (fr) 2007-11-28 2009-06-04 Commonwealth Scientific And Industrial Research Organisation Nanoémulsions
JP5490714B2 (ja) * 2007-11-28 2014-05-14 メディミューン，エルエルシー タンパク質製剤
US20100158998A1 (en) 2008-12-23 2010-06-24 Michael Fox Formulations comprising vitamin d or derivatives thereof
CN104146955A (zh) 2009-03-09 2014-11-19 普罗诺瓦生物医药挪威公司 含有脂肪酸油混合物和表面活性剂的组合物及其方法和用途
ES2530049T3 (es) * 2009-05-18 2015-02-26 Sigmoid Pharma Limited Composición que comprende gotas de aceite
WO2011075623A1 (fr) 2009-12-18 2011-06-23 Latitude Pharmaceuticals, Inc. Composition de gel à une phase comprenant des phospholipides
US20110229516A1 (en) * 2010-03-18 2011-09-22 The Clorox Company Adjuvant phase inversion concentrated nanoemulsion compositions
SE536746C2 (sv) 2010-05-12 2014-07-08 Stora Enso Oyj En komposition innehållande mikrofibrillerad cellulosa och en process för tillverkning av en komposition
US8835509B2 (en) 2010-05-31 2014-09-16 Arbro Pharmaceuticals Ltd. Self emulsifying drug delivery system for a curcuminoid based composition
KR20130139896A (ko) 2010-09-08 2013-12-23 프로노바 바이오파마 너지 에이에스 유리산 형태의 epa 및 dha, 계면활성제, 및 스타틴을 포함하는 조성물
WO2013008083A1 (fr) 2011-07-13 2013-01-17 National Institute Of Pharmaceutical Education And Research (Niper) Composition pharmaceutique pouvant améliorer l'efficacité anticancéreuse du tamoxifène
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Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997010814A1 (fr) * 1995-09-18 1997-03-27 Vesifact Ag Nanodispersions de propofol
WO2003077882A2 (fr) * 2002-03-18 2003-09-25 Labopharm Inc. Preparation de nanodispersions stabilisees steriles
EP2387991A1 (fr) * 2006-02-01 2011-11-23 Adventrx Pharmaceuticals, Inc. Compositions pharmaceutiques stabilisées à succinate de vitamine E, procédés de préparation et utilisation associée
WO2010146606A1 (fr) * 2009-06-19 2010-12-23 Sun Pharma Advanced Research Company Ltd., Nanodispersion d'un médicament et son procédé de préparation
US20110229554A1 (en) * 2010-03-12 2011-09-22 Niven Rajin Narain INTRAVENOUS FORMULATIONS OF COENZYME Q10 (CoQ10) AND METHODS OF USE THEREOF

Also Published As

Publication number Publication date
EP3129002A2 (fr) 2017-02-15
AU2015246030A1 (en) 2016-11-24
EA038458B1 (ru) 2021-08-31
MX2016013201A (es) 2017-04-25
AU2015246030B2 (en) 2020-03-12
US20180177723A1 (en) 2018-06-28
EA201692044A1 (ru) 2017-04-28
WO2015155703A2 (fr) 2015-10-15
IN2014CH01872A (fr) 2015-05-08
WO2015155703A3 (fr) 2015-12-30
US11458096B2 (en) 2022-10-04

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