EP3046511B1 - Procédé et appareil pour comprimer/charger des endoprothèses valvulaires - Google Patents

Procédé et appareil pour comprimer/charger des endoprothèses valvulaires Download PDF

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Publication number
EP3046511B1
EP3046511B1 EP14766978.2A EP14766978A EP3046511B1 EP 3046511 B1 EP3046511 B1 EP 3046511B1 EP 14766978 A EP14766978 A EP 14766978A EP 3046511 B1 EP3046511 B1 EP 3046511B1
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EP
European Patent Office
Prior art keywords
stent
valve
compressor stage
channel
compressing
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Active
Application number
EP14766978.2A
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German (de)
English (en)
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EP3046511A2 (fr
Inventor
Luc Mantanus
Fabien Lombardi
Pierre Simonin
Youssef Biadillah
Jean-Luc Hefti
Stéphane Delaloye
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Symetis SA
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Symetis SA
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Publication date
Application filed by Symetis SA filed Critical Symetis SA
Priority to EP21205429.0A priority Critical patent/EP4000560A1/fr
Priority to EP18163259.7A priority patent/EP3360514B1/fr
Priority to EP14766978.2A priority patent/EP3046511B1/fr
Publication of EP3046511A2 publication Critical patent/EP3046511A2/fr
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Publication of EP3046511B1 publication Critical patent/EP3046511B1/fr
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2427—Devices for manipulating or deploying heart valves during implantation
    • A61F2/2436—Deployment by retracting a sheath
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/9522—Means for mounting a stent or stent-graft onto or into a placement instrument
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418—Scaffolds therefor, e.g. support stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/962—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve
    • A61F2/97—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve the outer sleeve being splittable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0008—Fixation appliances for connecting prostheses to the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0028—Shapes in the form of latin or greek characters
    • A61F2230/0054—V-shaped
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0018—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in elasticity, stiffness or compressibility
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0091—Additional features; Implant or prostheses properties not otherwise provided for transparent or translucent

Landscapes

  • Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Claims (17)

  1. Appareil (40, 120) conçu pour comprimer une endoprothèse valvulaire cardiaque (10) à un diamètre externe maximal inférieur ou égal à environ 10 mm pour un chargement dans un cathéter de pose (12), l'appareil (40, 120) comprenant
    un premier étage de compression (100) pour comprimer l'endoprothèse valvulaire (10); et
    un second étage de compression (102) accouplé ou pouvant être accouplé au premier étage de compression (100) et conçu pour comprimer davantage une partie de l'endoprothèse valvulaire (10) après le passage par le premier étage de compression (100)
    dans lequel le premier étage de compression (100) comprend un canal creux (42), et le premier étage de compression (100) est conçu pour comprimer progressivement l'endoprothèse valvulaire en réponse à, ou en association avec, l'avancement longitudinal de l'endoprothèse valvulaire à l'intérieur du canal creux (42), caractérisé en ce que
    le second étage de compression (102) est conçu pour comprimer une partie de l'endoprothèse valvulaire au niveau du second étage de compression (102) sans l'avancement de l'endoprothèse valvulaire à l'intérieur du second étage de compression (102).
  2. Appareil (40, 120) selon la revendication 1, conçu pour une utilisation dans la compression d'une endoprothèse valvulaire cardiaque (10) ayant un diamètre externe maximal dans son état dilaté allant d'environ 25 mm à environ 35 mm.
  3. Appareil (40, 120) selon l'une quelconque des revendications précédentes, dans lequel le second étage de compression (102) est conçu pour appliquer une force radiale d'au moins 50 N.
  4. Appareil (40, 120) selon l'une quelconque des revendications précédentes, dans lequel le second étage de compression (102) est accouplé de façon libérable à une sortie du premier étage de compression (100), ou est destiné à l'être au niveau de celle-ci.
  5. Appareil (40, 120) selon l'une quelconque des revendications précédentes, dans lequel le second étage de compression (102) comprend une sertisseuse.
  6. Appareil (40, 120) selon la revendication 5, dans lequel la sertisseuse comprend une pluralité d'éléments mobiles.
  7. Appareil (40, 120) selon la revendication 5 ou 6, dans lequel la sertisseuse comprend des mâchoires (104) définissant un mandrin.
  8. Appareil (40, 120) selon l'une quelconque des revendications précédentes, dans lequel les premier et second étages de compression (100, 102) sont actionnés par des actionneurs rotatifs respectifs (46, 110) qui peuvent tourner sur un axe commun, éventuellement un axe longitudinal de l'appareil.
  9. Appareil (40, 120) selon l'une quelconque des revendications précédentes, dans lequel le second étage de compression (102) peut être fixé de façon libérable au premier étage de compression (100) au moyen d'un actionneur fileté (110) pour actionner le second étage de compression (102).
  10. Appareil (40, 120) selon l'une quelconque des revendications précédentes, dans lequel le premier étage de compression (100) comprend un ou plusieurs parmi (i) un élément de déplacement (44) pour appliquer à une valve endoprothétique (10) à l'intérieur du canal (42), une force de poussée dans le sens radial à partir de l'extérieur du canal (42) ; et/ou (ii) un élément d'entraînement (46) pour appliquer une force de poussée dans le sens radial à l'extérieur du canal (42) vers une partir de l'élément de déplacement (44) dans le sens radial à l'extérieur du canal (42).
  11. Appareil (40, 120) selon la revendication 10, dans lequel l'élément de déplacement comprend un anneau duquel dépassent vers l'intérieur plusieurs éléments, les éléments coulissant dans des fentes à travers une paroi du canal, pour appliquer une force de poussée à une endoprothèse valvulaire à l'intérieur du canal.
  12. Appareil (40, 120) selon l'une quelconque des revendications précédentes, comprenant en outre :
    une pluralité de segments (122a, 122b) qui peuvent être assemblés autour d'une partie d'un cathéter de pose (12) afin de définir une forme tubulaire ; et
    au moins un élément de retenue pour retenir la pluralité de segments (122a, 122b) dans la forme assemblée.
  13. Appareil (40, 120) selon la revendication 12, dans lequel l'élément de retenue comprend au moins un écrou fileté (126) et/ou un surtube de support (124).
  14. Procédé de compression d'une endoprothèse valvulaire (10), le procédé comprenant :
    (a) la fourniture d'un appareil comprenant un premier étage de compression (100) ayant un canal longitudinal (42), et un second étage de compression (102) accouplé ou pouvant être accouplé au premier étage de compression (100) pour comprimer une partie de l'endoprothèse valvulaire après le passage par le premier étage de compression ;
    (b) l'actionnement d'un actionneur (46) du premier étage de compression par rotation, pour faire avancer l'endoprothèse valvulaire à l'intérieur du canal creux (42), afin de comprimer progressivement l'endoprothèse valvulaire en réponse à, ou en association avec, l'avancement longitudinal à l'intérieur du canal creux (42) caractérisé par
    (c) l'actionnement du second étage de compression (102) afin de comprimer davantage une partie de l'endoprothèse valvulaire sans faire avancer l'endoprothèse valvulaire plus loin à l'intérieur du second étage de compression.
  15. Procédé selon la revendication 14, dans lequel l'étape d'actionnement du second étage de compression comprend l'actionnement d'un actionneur (110) du second étage de compression par rotation.
  16. Système comprenant :
    un cathéter de pose (12) possédant une région de confinement pour accueillir une endoprothèse valvulaire cardiaque, des première et seconde gaines (30a, 30b) conçues pour se déplacer dans des directions opposées afin de se fermer sur des parties respectives de l'endoprothèse valvulaire dans un état comprimé au niveau de la région de confinement ; et
    un appareil (40, 120) destiné à être utilisé dans la compression de l'endoprothèse valvulaire (10) pour un chargement dans le cathéter de pose (12), l'appareil (40, 120) comprenant :
    un premier étage de compression (100) pour comprimer l'endoprothèse valvulaire (10); et
    un second étage de compression (102) accouplé ou pouvant être accouplé au premier étage de compression (100) et conçu pour comprimer davantage une partie de l'endoprothèse valvulaire (10) après le passage par le premier étage de compression (100)
    le premier étage de compression (100) comprenant un canal creux (42), et le premier étage de compression (100) étant conçu pour comprimer progressivement l'endoprothèse en réponse à, ou en association avec, l'avancement longitudinal de l'endoprothèse à l'intérieur du canal creux (42), caractérisé en ce que
    le second étage de compression (102) est conçu pour comprimer une partie de l'endoprothèse au niveau du second étage de compression (102) sans l'avancement de l'endoprothèse à l'intérieur du second étage de compression (102).
  17. Système selon la revendication 16, dans lequel l'appareil (40, 120) est un appareil (40, 120) selon l'une quelconque des revendications 1 à 13.
EP14766978.2A 2013-09-16 2014-09-16 Procédé et appareil pour comprimer/charger des endoprothèses valvulaires Active EP3046511B1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP21205429.0A EP4000560A1 (fr) 2013-09-16 2014-09-16 Procédé et appareil pour compresser/charger des valvules d'endoprothèse
EP18163259.7A EP3360514B1 (fr) 2013-09-16 2014-09-16 Procédé et appareil pour compresser/charger des valvules d'endoprothèse
EP14766978.2A EP3046511B1 (fr) 2013-09-16 2014-09-16 Procédé et appareil pour comprimer/charger des endoprothèses valvulaires

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13184650 2013-09-16
EP14766978.2A EP3046511B1 (fr) 2013-09-16 2014-09-16 Procédé et appareil pour comprimer/charger des endoprothèses valvulaires
PCT/EP2014/069696 WO2015036617A2 (fr) 2013-09-16 2014-09-16 Procédé et appareil pour comprimer/charger des endoprothèses valvulaires

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP21205429.0A Division EP4000560A1 (fr) 2013-09-16 2014-09-16 Procédé et appareil pour compresser/charger des valvules d'endoprothèse
EP18163259.7A Division EP3360514B1 (fr) 2013-09-16 2014-09-16 Procédé et appareil pour compresser/charger des valvules d'endoprothèse

Publications (2)

Publication Number Publication Date
EP3046511A2 EP3046511A2 (fr) 2016-07-27
EP3046511B1 true EP3046511B1 (fr) 2018-03-28

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Application Number Title Priority Date Filing Date
EP18163259.7A Active EP3360514B1 (fr) 2013-09-16 2014-09-16 Procédé et appareil pour compresser/charger des valvules d'endoprothèse
EP14766978.2A Active EP3046511B1 (fr) 2013-09-16 2014-09-16 Procédé et appareil pour comprimer/charger des endoprothèses valvulaires
EP21205429.0A Pending EP4000560A1 (fr) 2013-09-16 2014-09-16 Procédé et appareil pour compresser/charger des valvules d'endoprothèse

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EP18163259.7A Active EP3360514B1 (fr) 2013-09-16 2014-09-16 Procédé et appareil pour compresser/charger des valvules d'endoprothèse

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Application Number Title Priority Date Filing Date
EP21205429.0A Pending EP4000560A1 (fr) 2013-09-16 2014-09-16 Procédé et appareil pour compresser/charger des valvules d'endoprothèse

Country Status (5)

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US (4) US10245145B2 (fr)
EP (3) EP3360514B1 (fr)
JP (1) JP6659934B2 (fr)
CN (1) CN105722476B (fr)
WO (1) WO2015036617A2 (fr)

Cited By (32)

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US10149756B2 (en) 2008-09-29 2018-12-11 Edwards Lifesciences Cardiaq Llc Heart valve
US10179044B2 (en) 2014-05-19 2019-01-15 Edwards Lifesciences Cardiaq Llc Replacement mitral valve
US10226335B2 (en) 2015-06-22 2019-03-12 Edwards Lifesciences Cardiaq Llc Actively controllable heart valve implant and method of controlling same
US10485660B2 (en) 2010-06-21 2019-11-26 Edwards Lifesciences Cardiaq Llc Replacement heart valve
US10575951B2 (en) 2015-08-26 2020-03-03 Edwards Lifesciences Cardiaq Llc Delivery device and methods of use for transapical delivery of replacement mitral valve
US10583000B2 (en) 2013-03-14 2020-03-10 Edwards Lifesciences Cardiaq Llc Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
US10610362B2 (en) 2010-09-23 2020-04-07 Edwards Lifesciences Cardiaq Llc Replacement heart valves, delivery devices and methods
US10716664B2 (en) 2013-03-14 2020-07-21 Edwards Lifesciences Cardiaq Llc Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
US10758345B2 (en) 2015-08-26 2020-09-01 Edwards Lifesciences Cardiaq Llc Replacement heart valves and methods of delivery
US10813757B2 (en) 2017-07-06 2020-10-27 Edwards Lifesciences Corporation Steerable rail delivery system
US10842620B2 (en) 2015-06-23 2020-11-24 Edwards Lifesciences Cardiaq Llc Systems and methods for anchoring and sealing a prosthetic heart valve
US10856984B2 (en) 2017-08-25 2020-12-08 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US10940001B2 (en) 2012-05-30 2021-03-09 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US10952849B2 (en) 2014-02-21 2021-03-23 Edwards Lifesciences Cardiaq Llc Prosthesis, delivery device and methods of use
US11051934B2 (en) 2018-02-28 2021-07-06 Edwards Lifesciences Corporation Prosthetic mitral valve with improved anchors and seal
US11058536B2 (en) 2004-10-02 2021-07-13 Edwards Lifesciences Cardiaq Llc Method for replacement of heart valve
US11141265B2 (en) 2006-07-28 2021-10-12 Edwards Lifesciences Cardiaq Llc Percutaneous valve prosthesis and system and method for implanting the same
US11253364B2 (en) 2015-08-28 2022-02-22 Edwards Lifesciences Cardiaq Llc Steerable delivery system for replacement mitral valve and methods of use
US11311376B2 (en) 2019-06-20 2022-04-26 Neovase Tiara Inc. Low profile prosthetic mitral valve
US11357622B2 (en) 2016-01-29 2022-06-14 Neovase Tiara Inc. Prosthetic valve for avoiding obstruction of outflow
US11376119B2 (en) 2009-04-15 2022-07-05 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery system
US11389291B2 (en) 2013-04-04 2022-07-19 Neovase Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
US11389292B2 (en) 2015-04-30 2022-07-19 Edwards Lifesciences Cardiaq Llc Replacement mitral valve, delivery system for replacement mitral valve and methods of use
US11413139B2 (en) 2011-11-23 2022-08-16 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US11419720B2 (en) 2010-05-05 2022-08-23 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis
US11464631B2 (en) 2016-11-21 2022-10-11 Neovasc Tiara Inc. Methods and systems for rapid retraction of a transcatheter heart valve delivery system
US11491006B2 (en) 2019-04-10 2022-11-08 Neovasc Tiara Inc. Prosthetic valve with natural blood flow
US11497602B2 (en) 2012-02-14 2022-11-15 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US11602429B2 (en) 2019-04-01 2023-03-14 Neovasc Tiara Inc. Controllably deployable prosthetic valve
US11684474B2 (en) 2018-01-25 2023-06-27 Edwards Lifesciences Corporation Delivery system for aided replacement valve recapture and repositioning post-deployment
US11737872B2 (en) 2018-11-08 2023-08-29 Neovasc Tiara Inc. Ventricular deployment of a transcatheter mitral valve prosthesis
US11779742B2 (en) 2019-05-20 2023-10-10 Neovasc Tiara Inc. Introducer with hemostasis mechanism

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US8092520B2 (en) 2005-11-10 2012-01-10 CardiAQ Technologies, Inc. Vascular prosthesis connecting stent
CN105722476B (zh) * 2013-09-16 2018-07-20 西美蒂斯股份公司 用于压缩/装载支架-瓣膜的方法和装置
US10195025B2 (en) * 2014-05-12 2019-02-05 Edwards Lifesciences Corporation Prosthetic heart valve
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US20190290427A1 (en) 2019-09-26
CN105722476B (zh) 2018-07-20
US10245145B2 (en) 2019-04-02
JP2016530046A (ja) 2016-09-29
EP3360514A1 (fr) 2018-08-15
US20230414352A1 (en) 2023-12-28
EP4000560A1 (fr) 2022-05-25
US10682228B2 (en) 2020-06-16
WO2015036617A2 (fr) 2015-03-19
CN105722476A (zh) 2016-06-29
US11786372B2 (en) 2023-10-17
US20200205971A1 (en) 2020-07-02
JP6659934B2 (ja) 2020-03-04
US20160228249A1 (en) 2016-08-11
EP3360514B1 (fr) 2021-11-03
EP3046511A2 (fr) 2016-07-27
WO2015036617A3 (fr) 2015-04-30

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