EP3027255A1 - Appareil de traitement aérosol avec réglage de pression positive dans les voies aériennes - Google Patents

Appareil de traitement aérosol avec réglage de pression positive dans les voies aériennes

Info

Publication number
EP3027255A1
EP3027255A1 EP14758668.9A EP14758668A EP3027255A1 EP 3027255 A1 EP3027255 A1 EP 3027255A1 EP 14758668 A EP14758668 A EP 14758668A EP 3027255 A1 EP3027255 A1 EP 3027255A1
Authority
EP
European Patent Office
Prior art keywords
mixing chamber
inlet
flow
valve
chamber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP14758668.9A
Other languages
German (de)
English (en)
Inventor
Luigi Abate
Riccardo Abate
Mauro Bertelli
Nicola Fraccaroli
Silvio DI PAOLO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Flaem Nuova SpA
Original Assignee
Flaem Nuova SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flaem Nuova SpA filed Critical Flaem Nuova SpA
Publication of EP3027255A1 publication Critical patent/EP3027255A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/06—Respiratory or anaesthetic masks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/14—Preparation of respiratory gases or vapours by mixing different fluids, one of them being in a liquid phase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0013—Details of inhalators; Constructional features thereof with inhalation check valves
    • A61M15/0015—Details of inhalators; Constructional features thereof with inhalation check valves located upstream of the dispenser, i.e. not traversed by the product
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0057—Pumps therefor
    • A61M16/0063—Compressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/1075—Preparation of respiratory gases or vapours by influencing the temperature
    • A61M16/1095—Preparation of respiratory gases or vapours by influencing the temperature in the connecting tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/20—Valves specially adapted to medical respiratory devices
    • A61M16/208—Non-controlled one-way valves, e.g. exhalation, check, pop-off non-rebreathing valves
    • A61M16/209—Relief valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A61M2205/3653—General characteristics of the apparatus related to heating or cooling by Joule effect, i.e. electric resistance

Definitions

  • the present invention in its more general aspect, relates to an apparatus for aerosol therapy with adjustable positive airway pressure for the treatment of a subject (patient) with reduced inhalation power, i.e. a subject with a FEV1 (Forced Expiratory Volume in the 1st second) value lower than its own predictive value, for example due to cystic fibrosis, asthma, bronchiectasis and similar obstructive bronchopulmonary pathologies.
  • FEV1 Forced Expiratory Volume in the 1st second
  • the inhalation power of a subject is generally indicated by the so called FEV1 or VEMS (Volume Espiratorio Massimo nel 1° secondo), parameter indicating the volume of air expired during the first second of a maximum forced expiration and indicating the patency degree of large airways.
  • FEV1 or VEMS Volume Espiratorio Massimo nel 1° secondo
  • the inhalation power is indeed decreased and it can be more or less severely reduced, based on the degree of bronchial obstruction and sometimes, further, its variability can also be poorly predictable.
  • cystic fibrosis cystic fibrosis
  • chronic obstructive bronchitis chronic obstructive bronchitis
  • bronchiectasis obstructive bronchopulmonary pathologies which are often healed or however treated, inter alia, also by aerosol therapy.
  • the classical therapy by aerosol is not free from drawbacks and, specifically, suffers a possible decreased ventilation power of a person subjected thereto, meaning that the therapy itself, in such cases, loses at least part of its efficiency due to the impaired pulmonary function of the treated person.
  • mucus plugs can obstruct the airways to a large extent thereby perturbing the air flow of nebulized particles, thus decreasing the penetration thereof.
  • cystic fibrosis which, as known, is a rare genetic disease caused by an abnormal function of the CFTR ⁇ Cystic Fibrosis Transmembrane Regulator) protein regulating the intracellular ion exchange, specifically of chlorine, is has to be said that, among the most serious complications, it results in the dehydration of the liquid periciliary film which coats the airways and causes an impairment of the capability of expectorating the secretions with following bronchial obstruction, bacterial infections and inflammation of the respiratory tree.
  • a concentrated saline solution such as the above mentioned hypertonic solutions, is able to draw water to the airways of a person subjected to such a treatment and, therefore, it is able to restore the periciliary aqueous film thus to at least partially restore the mucus ciliary function impaired by the disease.
  • the therapy with highly hypertonic nebulized solutions is however not free from drawbacks and undesirable effects among which a bothersome irritating pro-cough effect on the upper airways, a bronchial contraction effect which can cause the dosing termination and which however decreases the capability of carrying the aerosol in the deepest airways.
  • the treatment with concentrated and nebulized saline solutions generally adjoins to other treatments carried out via inhalation, such as for example the antibiotic therapy or the therapy with mucolytics such as the DNase.
  • inhalation therapies a patient suffering from chronic pulmonary disease has to be subjected to, dictates to have available inhalation systems which are effective regardless from the severity of the ventilation asset of the patient and thus provide with an effective inhalation therapy also the most impaired patients having FEV1 ⁇ 50-60% of the afore predictive value.
  • US 2008/0000470 describes an inhalation device for delivering a pulmonary surfactant nebulized in the therapeutic treatment of preterm infants comprising an aerosol generator, means for generating an air flow, a nebulizing chamber having a tapered area and means for intubating the patient connected to the tapered area of the nebulizing chamber.
  • An object of the present invention is therefore to provide an apparatus for aerosol therapy for the therapy and the treatment of obstructive bronchopulmonary diseases and, particularly, of diseases featured by a FEV1 value lower than a predictive value for a given person subjected to the aerosol therapy (decreased inhalation power), having structural and functional characteristics such to overcome the above mentioned drawbacks and in particular such to improve the pulmonary deposition of the nebulized item upon which the aerosol therapy is based or, however, such to render the pulmonary deposition of the afore said nebulized item as independent from the FEV1 value as possible.
  • a further object of the present invention is to provide an apparatus for aerosol therapy for the treatment and the care of the cystic fibrosis, particularly but not exclusively through delivery of highly hypertonic solutions, which has structural and functional characteristics such to overcome the above mentioned drawbacks and, in particular, such to allow an improvement of the treatment effectiveness on one hand and a reduction of the unpleasantness of the same and the annoyance suffered by a patient subjected to the treatment on the other hand.
  • an apparatus for aerosol therapy for the treatment and care of obstructive bronchopulmonary diseases specifically of diseases featured by a FEV1 value lower than a predictive value of a given person subjected to the aerosol therapy, particularly but not exclusively of cystic fibrosis, chronic obstructive bronchitis, bronchiectasis and asthma, apt to the delivery of a nebulized item, particularly but not exclusively of a highly hypertonic solution, i.e.
  • the afore said apparatus comprises a mixing chamber having a tapered ending portion and provided with a first and a second inlet openings and at least one outlet opening arranged at the afore said tapered ending portion, a nebulizing chamber comprising an atomizing nozzle, which is outside the afore said mixing chamber and fluidically connected therewith through the afore said first inlet, a compressing device connected to the afore said nebulizing chamber to feed a flow of compressed air to the atomizing nozzle, a ventilation device/CPAP connected to the afore said mixing chamber through the afore said second inlet for feeding a flow of ventilation air therein, and an inhalation mask connected to the afore said mixing chamber through the afore said outlet.
  • a mixing chamber having a tapered ending portion and provided with a first and a second inlet openings and at least one outlet opening arranged at the afore said tapered ending portion
  • a nebulizing chamber comprising
  • the apparatus comprises a tubular feeding element of the flow of ventilation air, having a tapered ending portion and connected to the afore said CPAP or ventilation device comprising, for example, a turbine and pressure sensors, and being associated with the afore said mixing chamber at the afore said second inlet, in particular associated with the same and free to slide therewith, at least for an extent of preset length wherein the afore said tapered ending portion, inside the mixing chamber, can have various distances from the afore said outlet.
  • a tubular feeding element of the flow of ventilation air having a tapered ending portion and connected to the afore said CPAP or ventilation device comprising, for example, a turbine and pressure sensors, and being associated with the afore said mixing chamber at the afore said second inlet, in particular associated with the same and free to slide therewith, at least for an extent of preset length wherein the afore said tapered ending portion, inside the mixing chamber, can have various distances from the afore said outlet.
  • the apparatus according to the invention is a so called closed- circuit apparatus and comprises a first valve, preferably arranged in the mixing chamber and still preferably comprises a sealing gasket arranged peripherally on an outer edge of the afore said inhalation mask.
  • the afore said first valve is a relief valve or a PEP valve ⁇ positive Expiratory Pressure) apt to be active and open during an expiratory step, i.e. a one-way valve provided with a relief opening having determined limited dimensions or provided/associated with an adjustable expiratory mechanical resistance, such to generate a pressure up to 20 cm H 2 0.
  • the apparatus according to the invention is apt to operate in overpressure, due to the afore said ventilation device or CPAP, advantageously with a pressure comprised from 2 to 20 cm H 2 0 and preferably from about 4 to about 8 cm H 2 0.
  • the apparatus according to the invention comprises means for heating the afore said flow of ventilation air, more preferably heating means comprising a fitting duct, an electric power source and at least one electric resistance associated with said fitting duct and connected to the afore said electric power source, wherein the afore said fitting duct is interposed between the afore said ventilation device or CPAP and the afore said ventilation chamber or else possibly the afore said feeding element.
  • the afore said mixing chamber comprises a cylindrical portion and a frusto-conical portion, consecutive one to another, the afore said outlet being preferably concentric to the afore said second inlet thus possibly concentric to the afore said tapered ending portion of the feeding element.
  • the afore said nebulizing chamber is provided with an opening engaged by a second valve or valve for recovering air to be fed into the mixing chamber, i.e. a valve apt to be active and open during an inspiration step of a person subjected to the aerosol therapy treatment.
  • the present apparatus allows delivering a nebulized item to a subject, for example an aerosol comprising, or composed of, a specific medication for the disease to be treated, or a highly hypertonic solution, realized in the nebulizing chamber, advantageously after mixing with a positive-pressure flow of ventilation air, wherein the mixing speed between the nebulized item and the flow of ventilation air, and the particle size of the nebulized item in the same flow of ventilation air can be adjusted by means of the axial movement of the feeding element with respect to the mixing chamber.
  • the tapered ending portion of the feeding element having a section lower than a main portion of the same feeding element and arranged inside the mixing chamber, having in its turn a section larger than the section of the feeding element, and the position adjustable with respect to the outlet of the mixing chamber of the afore said tapered ending portion, as a matter of fact allow suctioning from the nebulizing chamber, by means of the afore said second valve, more or less nebulized item depending on the depression generated by Venturi effect in the mixing chamber.
  • nebulized item is suctioned depending on the opening degree of the afore said second valve, whereas during the expiration step the flow of excess air of a patient subjected to treatment by the present apparatus is relieved outwards, through the afore said first valve.
  • the particular combination of the present apparatus made of a compressing device and an atomizing nozzle to generate an aerosol of medications and, advantageously, also of essentially fat compounds, for example solutions with hyaluronic and/or linoleic acid, a ventilation device for example comprising a turbine and pressure sensors or CPAP to realize a flow of positive pressure ventilation air, a mixing chamber having a ending portion tapered at the outlet wherein the aerosol and the flow of ventilation air are mixed before the delivery to a patient, and the inhalation mask, allows increasing the effectiveness of the aerosol therapy, thereby allowing a pulmonary deposition of the nebulized item which is substantially not affected by a possible FEV1 limit, i.e. the reduced ventilation power of the treated subject.
  • a ventilation device for example comprising a turbine and pressure sensors or CPAP to realize a flow of positive pressure ventilation air
  • a mixing chamber having a ending portion tapered at the outlet wherein the aerosol and the flow of ventilation air are mixed before the delivery to a patient
  • the variability relating to the inspiration force of a patient subjected to aerosol therapy through the present apparatus is overcome since the person does not have to forcedly inhale the medication rather the latter has to forcedly penetrate directly into the airways.
  • the flow of ventilation air (positive air flow) facilitates the aerodynamics by reducing the interaction of the nebulized with the high airways, thus allowing a higher medication percent in the low airways.
  • the present apparatus allows delivering a highly hypertonic solution, possibly and advantageously still comprising essentially fat compounds which, due to the increased pulmonary deposition in spite of the deposition in high airways of the nebulized item, reduces the annoyance suffered by a patient subjected to aerosol therapy, due to the unpleasantness, in particular bad palatability, of the hypertonic solution and to irritant effects at the throat and pharynx.
  • the present apparatus is conceived to be used at the patient home also, and is therefore easily portable, having little dimensions, weight and bulk, while allowing the use of the great majority of medications usually employed by inhalation.
  • FIG. 1 shows schematically an apparatus for aerosol therapy with adjustable positive airway pressure adjustable during its use on a patient, in accordance with an embodiment of the present invention
  • figure 2 illustrates in a longitudinal section a particular of the apparatus of figure 1;
  • figure 3 illustrates an additional particular of the apparatus of figure 1;
  • figure 4 illustrates an additional particular, partially in section, of the apparatus of figure 1.
  • an apparatus for aerosol therapy with adjustable positive airway pressure in accordance with the present invention is wholly indicated by the numeral 1.
  • the apparatus particularly suitable for the treatment and the therapy of obstructive bronchopulmonary diseases, essentially comprises a mixing chamber 2 provided with inlets and outlets, a nebulizing chamber 3 wherein an atomizing nozzle 4 is housed, which is arranged outside the mixing chamber 2 and both unidirectionally and fluidically connected therewith, a compressing device 5 connected to the nebulizing chamber 3 to feed a flow of compressed air to the atomizing nozzle 4, a ventilation device (for example a turbine type with pressure sensors) or CPAP 6 connected to the mixing chamber 2 to feed a flow of ventilation air therein, and an inhalation mask 7 connected to the mixing chamber 2.
  • a mixing chamber 2 provided with inlets and outlets
  • a nebulizing chamber 3 wherein an atomizing nozzle 4 is housed, which is arranged outside the mixing chamber 2 and both unidirectionally and fluidically connected therewith
  • a compressing device 5 connected to the nebulizing chamber 3 to feed a flow of compressed air to the atomizing nozzle
  • the mixing chamber 2 is provided with a first inlet 8 and a second inlet 9 through which the afore said fluid communication with the nebulizing chamber 3 and, respectively, with the ventilation device or CPAP 6 is realized.
  • the mixing chamber 2 comprises an outlet 10 arranged opposite to the inlets 8 and 9 through which a fluid communication is realized with the inhalation mask 7.
  • the mixing chamber 2 comprises a cylindrical portion and a frusto-conical portion, consecutive one to another, and comprises in detail a tapered ending portion 11 at which the outlet 10, which is advantageously concentric to the second inlet 9, is provided.
  • the present apparatus also comprises a feeding element 12 of the flow of ventilation air, having a tubular shape and a tapered ending portion 13.
  • the feeding element 12 is connected at one side to the ventilation device or CPAP 6 and, on the other side, is associated with the mixing chamber 2 at the second inlet 9 and, in particular, is slidingly associated, i. e. axially free, with the mixing chamber 2 at least for an extent of preset length wherein the tapered ending portion 13 of the feeding element 12 is inside the mixing chamber 2 at various distances from the outlet 10.
  • the sliding of the feeding element 12 with respect to the mixing chamber 2 can be provided continuously or along predetermined discrete positions.
  • the apparatus 1 comprises means for heating the flow of ventilation air, on the whole indicated by the numeral 14, which advantageously comprise a fitting duct 15, an electric power source 16, and at least one electrical resistance associated with the fitting duct 15 and connected to the electric power source 16, not represented in the figures.
  • the fitting duct 15 is interposed between the ventilation device or CPAP 6 and the mixing chamber 2, particularly between the ventilation device or CPAP 6 and the feeding element 12.
  • the apparatus 1 comprises a first valve 17 advantageously housed in the mixing chamber 2, which can be a pre-calibrated or variable relief valve or a PEP valve active during the expiratory step according to the needs, i.e. a one-way valve provided with a relief opening having preset limited dimensions or provided/associated with an adjustable expiratory mechanical resistance, such to generate a pressure up to 20 cm H 2 0.
  • a first valve 17 advantageously housed in the mixing chamber 2, which can be a pre-calibrated or variable relief valve or a PEP valve active during the expiratory step according to the needs, i.e. a one-way valve provided with a relief opening having preset limited dimensions or provided/associated with an adjustable expiratory mechanical resistance, such to generate a pressure up to 20 cm H 2 0.
  • the first valve 17 is arranged on the same side of the inlets 8 and 9 and is active and open during an expiration step of a person subjected to treatment with the present apparatus, in particular for the relief of a flow of exceeding air or to generate the afore said PEP pressure up to 20 cm H 2 0.
  • the present apparatus is of the so called closed-circuit type and in use provides a working over-pressure from 2 to 20 cm H 2 0 and preferably from about 4 to about 8 cm H 2 0, advantageously generated by the afore said ventilation device comprising a turbine and pressure sensors or CPAP, for example.
  • the present apparatus comprises a sealing gasket 18, arranged peripherally on an outer edge 19 of the inhalation mask 7.
  • the apparatus 1 is provided with a second valve 20 which engages a suitable opening arranged in the upper portion of the nebulizing chamber 3.
  • the second valve 20 is a usually closed valve for recovering air to be fed into the mixing chamber and can be active and open during an inspiration step of a person subjected to the treatment of aerosol therapy.
  • the nebulizing chamber 3 is advantageously constituted by a nebulizing ampule, for example of known type marketed by the same applicant.
  • the present apparatus allows obtaining a nebulizing speed of about 0.5 ml/min.
  • Maximizing the pulmonary deposition of the nebulized not only means increasing the treatment effectiveness, but also reducing the annoyance suffered by the patient in case of treatment by hypertonic solutions which are particularly unpleasant.
  • the apparatus according to the invention advantageously allows a pre- mixing of the nebulized item with a flow of ventilation air thus making the inspiration step of the person subjected to aerosol therapy easier and, advantageously, by virtue of the atomizing nozzle of pneumatic type it allows nebulizing practically any substance useful for the treatment, comprising essentially fat substances, differently from ultrasound electrical apparatuses for aerosol therapy.
  • a further advantage is the possibility of adjusting the mixing between nebulized item and flow of ventilation air, therefore substantially the speed and the flow rate with which the nebulized item is delivered, due to the shape of the feeding element and in particular due to its tapered ending portion and the possibility of axially displacing the same with respect to the mixing chamber.
  • a further advantage is the portability of the present apparatus which makes it suitable to be used in domestic environment as well.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catching Or Destruction (AREA)
  • Fire-Extinguishing Compositions (AREA)

Abstract

La présente invention concerne un appareil de traitement aérosol (1) avec réglage de pression positive dans les voies aériennes pour le traitement et la thérapie de maladies broncho-pulmonaires obstructives, comportant une chambre de mélange (2) présentant une partie d'extrémité tronconique (11) et dotée d'un premier et d'un second orifice d'entrée (8 ; 9) et d'au moins un orifice de sortie (10), celui-ci étant disposé à la partie d'extrémité tronconique, une chambre de nébulisation (3), comprenant une buse de pulvérisation (4), qui se trouve à l'extérieur de la chambre de mélange et qui est en communication fluidique avec celle-ci à travers le premier orifice d'entrée, un dispositif de compression connecté à la chambre de nébulisation pour alimenter un flux d'air comprimé à la buse de pulvérisation, un dispositif de ventilation/de pression positive continue connecté à la chambre de mélange à travers le second orifice d'entrée (9) pour y alimenter un flux d'air de ventilation, et un masque d'inhalation (7) connecté à la chambre de mélange (2) à travers l'orifice de sortie (10).
EP14758668.9A 2013-08-02 2014-07-28 Appareil de traitement aérosol avec réglage de pression positive dans les voies aériennes Withdrawn EP3027255A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000118A ITBS20130118A1 (it) 2013-08-02 2013-08-02 Apparecchiatura per aerosolterapia a pressione positiva regolabile
PCT/IB2014/063474 WO2015015394A1 (fr) 2013-08-02 2014-07-28 Appareil de traitement aérosol avec réglage de pression positive dans les voies aériennes

Publications (1)

Publication Number Publication Date
EP3027255A1 true EP3027255A1 (fr) 2016-06-08

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EP14758668.9A Withdrawn EP3027255A1 (fr) 2013-08-02 2014-07-28 Appareil de traitement aérosol avec réglage de pression positive dans les voies aériennes

Country Status (3)

Country Link
EP (1) EP3027255A1 (fr)
IT (1) ITBS20130118A1 (fr)
WO (1) WO2015015394A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4144392A1 (fr) 2021-09-06 2023-03-08 Air Liquide Medical Systems S.R.L. Dispositif d'aérosolthérapie comprenant un boîtier en matériau biopolymères

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10315002B2 (en) 2015-03-24 2019-06-11 Ventec Life Systems, Inc. Ventilator with integrated oxygen production
WO2017035769A1 (fr) * 2015-09-01 2017-03-09 温玉桂 Dispositif d'atomisation ménager
WO2017035778A1 (fr) * 2015-09-01 2017-03-09 温玉桂 Dispositif d'atomisation à distance
US10773049B2 (en) 2016-06-21 2020-09-15 Ventec Life Systems, Inc. Cough-assist systems with humidifier bypass
EP4218877A3 (fr) * 2016-08-15 2023-08-30 Fisher & Paykel Healthcare Limited Adaptateur pour systèmes d'assistance respiratoire
EP3678719B1 (fr) * 2017-09-06 2023-04-05 3A Health Care S.R.L. Dispositif de thérapie par aérosol
US11191915B2 (en) * 2018-05-13 2021-12-07 Ventec Life Systems, Inc. Portable medical ventilator system using portable oxygen concentrators
CN109893729B (zh) * 2019-04-11 2021-04-06 冀新红 一种呼吸系统治疗器

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2806000B1 (fr) * 2000-03-10 2002-05-31 Intertechnique Sa Equipement de protection de tete a mise en place rapide
MXPA02010884A (es) * 2000-05-05 2003-03-27 Aerogen Ireland Ltd Aparato y metodo para el suministro de medicamentos al sistema respiratorio.
US6986353B2 (en) * 2002-08-21 2006-01-17 Medical Device Group, Inc. Divided nasal cannula assembly
DE102006006183A1 (de) * 2006-02-10 2007-08-16 Pari GmbH Spezialisten für effektive Inhalation Inhalationstherapievorrichtung für die Anwendung bei Frühgeborenen und Kleinkindern
US7861710B2 (en) * 2006-06-30 2011-01-04 Aeris Therapeutics, Inc. Respiratory assistance apparatus and method
US8616200B2 (en) * 2009-01-16 2013-12-31 Westmed, Inc. Reservoir system for gas delivery to a patient

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2015015394A1 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4144392A1 (fr) 2021-09-06 2023-03-08 Air Liquide Medical Systems S.R.L. Dispositif d'aérosolthérapie comprenant un boîtier en matériau biopolymères

Also Published As

Publication number Publication date
ITBS20130118A1 (it) 2015-02-03
WO2015015394A1 (fr) 2015-02-05

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