Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
  • A61K8/26—Aluminium; Compounds thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/34—Alcohols
  • A61K8/345—Alcohols containing more than one hydroxy group
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/34—Alcohols
  • A61K8/347—Phenols
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
  • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
  • A61K2800/30—Characterized by the absence of a particular group of ingredients

Definitions

• a toothpaste composition having:
• abrasives may also be used along with the calcium based abrasive, depending upon the intended degree of abrasion.
• These include synthetic abrasive polishing agents such as amorphous precipitated silica and silica gels.
• Other abrasive agents include magnesium carbonate, sodium metaphosphate, potassium metaphosphate, zirconium silicate, potassium metaphosphate, magnesium orthophosphate, tricalcium phosphate, magnesium orthophosphate, trimagnesium phosphate, aluminum silicate, zirconium silicate and perlite.
• the disclosed composition contains upto 2 wt% thickening silica.
• Conventional gels contain upto 8 wt% thickening silica whereas opaque products typically have 4 to 10 wt%.
• Excessive thickening silica causes an adverse effect on release of flavor ingredients.
• Preferred compositions have 1 .5 wt%, or even less than 1 wt% thickening silica.
• Optimal compositions have less than 0.5 wt% thickening silica.
• Toothpaste compositions typically contain about 20 wt% humectants, which is usually a combination of humectants. This necessitates the inclusion of from about 4 to 6 wt% thickening silica. Such toothpastes have excellent sensory profile, therefore highly preferred by consumers. On the other hand, products with humectants of about 6 to 10 wt% have less preferred sensory profile which may get further affected on reducing the silica content.
• compositions have 3 to 15 wt%, more preferably 4 to 12 wt% and most preferably 6 to 12 wt% total humectant.
• a particularly preferred humectant is sorbitol which is generally available in the form of 70% aqueous solution. Therefore, where sorbitol is used as a humectant, its actual dosage in the formulation is higher than the desired percentage to account for the water in the commercial product.
• Suitable examples include quaternary ammonium compounds such as cetylpyridinium chloride; bis-biguanides such as chlorhexidine, chlorhexidine digluconate, hexetidine, octenidine, alexidine, TRICLOSAN ® and other halogenated bisphenolic compounds such as 2,2' methylenebis-(4-chloro-6-bromophenol).
• a particularly preferred antibacterial agent is TRICLOSAN ® ; a broad-spectrum antimicrobial agent widely used in oral care products.
• compositions which include an antibacterial agent, preferably triclosan we have observed significantly high uptake of the antibacterial agent by dental tissues including teeth. This is a hitherto unreported technical effect which is believed to be due to the presence of smectite clay.
• CHEC carboxymethylhydroxyethyl cellulose
• HPHEC hydroxypropylhydroxyethyl cellulose
• MC methyl cellulose
• MHPC methylhydroxypropyl cellulose
• MHEC methylhydroxyethyl cellulose
• carboxymethylmethyl cellulose CMMC
• HMCMC hydrophobically modified carboxymethyl cellulose
• HMHPC hydrophobically modified hydroxypropyl cellulose
• HMEHEC hydrophobically modified ethylhydroxyethyl cellulose
• HMHPHEC hydrophobically modified hydroxypropylhydroxyethyl cellulose
• a highly preferred binder is Sodium carboxymethyl cellulose (SCMC).
• SCMC Sodium carboxymethyl cellulose
• Particularly preferred sodium carboxymethyl celluloses include those with degree of substitution of from 0.6 to 0.99, preferably from 0.7 to 0.95.
• preferred SCMCs include those with viscosity of 250 mPa.s to 10000 mPa.s as measured on a Brookfield viscometer TA spindle at 30 rpm, 23 °C and reading after 30 seconds when slurried with flavour in a 1 :1 ratio.
• compositions which have cellulosic binder in addition to the smectite clay the ratio of the amount of smectite clay to the cellulosic binder is in the range of 1 :0.2 to 1 :0.9.
• Excessive cellulosic binder leads to compositions which may show tailing effect while dispensing the composition on a toothbrush.
• most of the cellulosic binders and some others like carrageenan are expensive ingredients.
• compositions may also include one or more other ingredients as described hereinafter.
• Other thickening agents may also include one or more other ingredients as described hereinafter.
• Preferred toothpaste compositions can include alkali metal silicate.
• the alkali metal is sodium or potassium, preferably sodium.
• Sodium silicate is generally available as 10 to 40 % aqueous solution, most common being 30 % solution.
• Sodium silicate is available as neutral sodium silicate or alkaline sodium silicate.
• Preferred toothpastes have neutral sodium silicate.
• Sodium silicate is available with varying ratios of Na 2 0: Si0 2 .
• Anionic surfactants useful herein include the water-soluble salts of alkyl sulfates having from 8 to 20 carbon atoms in the alkyl radical (e.g., sodium alkyl sulfate) and the water- soluble salts of sulfonated monoglycerides of fatty acids having from 8 to 20 carbon atoms.
• Sodium lauryl sulfate and sodium coconut monoglyceride sulfonates are examples of anionic surfactants of this type.
• Titanium dioxide can also be added to the composition for opacity. Titanium dioxide is generally included from 0.25 to 5 wt%. It is preferred that the toothpaste compositions contain a flavour. Suitable flavoring components include oil of wintergreen, oil of peppermint, oil of spearmint, clove bud oil, menthol, anethole, methyl salicylate, eucalyptol, cassia, 1-menthyl acetate, sage, eugenol, parsley oil, oxanone, alpha-irisone, marjoram, lemon, orange, propenyl guaethol, cinnamon, vanillin, ethyl vanillin, heliotropine, 4-cis-heptenal, diacetyl, methyl- para-tert-butyl phenyl acetate, and mixtures thereof.
• Suitable flavoring components include oil of wintergreen, oil of peppermint, oil of spearmint, clove bud oil, menthol, anethole
• a preferred toothpaste composition having the formulation as in table 5 was prepared.
• the preferred composition reduces growth of mutans Streptococci by a significantly better margin as compared to other toothpastes.

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• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Veterinary Medicine (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Birds (AREA)
• Epidemiology (AREA)
• Inorganic Chemistry (AREA)
• Chemical & Material Sciences (AREA)
• Emergency Medicine (AREA)
• Oral & Maxillofacial Surgery (AREA)
• Cosmetics (AREA)

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• 2014
  • 2014-03-25 CN CN201480021383.9A patent/CN105142597A/zh active Pending
  • 2014-03-25 WO PCT/EP2014/055891 patent/WO2014170096A1/en active Application Filing
  • 2014-03-25 EP EP14711984.6A patent/EP2986271A1/de not_active Withdrawn

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